keyword
MENU ▼
Read by QxMD icon Read
search

mdma

keyword
https://www.readbyqxmd.com/read/29453997/effects-of-para-methoxyamphetamine-pma-on-agonistic-encounters-between-male-mice
#1
Mercedes Martín-López, Ana T Muela, María Cavas, José Francisco Navarro
Para-methoxyamphetamine (PMA) is a synthetic drug chemically similar to the recreational drug 3,4-methylenedioxy-methamphetamine (MDMA or "ecstasy") and often replaces MDMA in tablets that show an "ecstasy" logo. PMA displays a higher toxic potential than MDMA, but the behavioral profile of PMA has been scarcely studied in animal models. Here we evaluated the effects of PMA (2, 4, 8, and 12 mg/kg, i.p.) on agonist encounters between male mice using an ethopharmacological approach, the isolation-induced aggression model...
February 14, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29453444/positive-regulation-of-raphe-serotonin-neurons-by-serotonin-2b-receptors
#2
Arnauld Belmer, Emily Quentin, Silvina L Diaz, Bruno P Guiard, Sebastian P Fernandez, Stéphane Doly, Sophie M Banas, Pothitos M Pitychoutis, Imane Moutkine, Aude Muzerelle, Anna Tchenio, Anne Roumier, Manuel Mameli, Luc Maroteaux
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT 2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT 2B receptors in mice eliminates the effects of molecules that directly target serotonergic neurons including amphetamine derivative serotonin releasers, and selective serotonin reuptake inhibitor antidepressants. In this work, we tested the hypothesis that 5-HT 2B receptors directly and positively regulate raphe serotonin neuron activity...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29432087/mdma-ecstasy-molly-use-among-african-americans-the-perceived-influence-of-hip-hop-rap-music
#3
Khary K Rigg, Anthony T Estreet
Over the past two decades, the demographic profile of MDMA (ecstasy/molly) users has changed. In particular, African American MDMA use has risen in some cities. One explanation of this new trend is the drug's recent popularity (as molly) in hip-hop/rap (HHR) music. Several top rappers endorse the drug as a way to have fun or get women "loose." There are currently no studies, however, that investigate the extent to which African American MDMA users listen to HHR music or the influence that these pro-MDMA messages have on their use of the drug...
February 12, 2018: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/29430277/a-comparison-of-self-reported-sexual-effects-of-alcohol-marijuana-and-ecstasy-in-a-sample-of-young-adult-nightlife-attendees
#4
Joseph J Palamar, Marybec Griffin-Tomas, Patricia Acosta, Danielle C Ompad, Charles M Cleland
Alcohol, marijuana, and ecstasy (3,4-methylenedioxymethamphetamine [MDMA], 'Molly') are among the most prevalent substances used by young adults; however, few studies have focused on the specific sexual effects associated with use. Examining subjective sexual effects (e.g. increased libido) associated with use can inform prevention efforts. Data were analysed from 679 nightclub and dance festival attendees in New York City (ages 18-25) to examine and compare self-reported sexual effects associated with use of alcohol, marijuana, and ecstasy...
2018: Psychology and Sexuality
https://www.readbyqxmd.com/read/29427652/evaluating-the-abuse-potential-of-psychedelic-drugs-for-medical-use-in-humans
#5
REVIEW
David J Heal, Jane Gosden, Sharon L Smith
Psychedelics comprise drugs come from various pharmacological classes including 5-HT 2A agonists, indirect 5-HT agonists, e.g. MDMA, NMDA antagonists and κ-opioid receptor agonists. There is resurgence in developing psychedelics to treat psychiatric disorders with high unmet clinical need. Many, but not all, psychedelics are schedule 1 controlled drugs (CDs), i.e. no approved medical use. For existing psychedelics in development, regulatory approval will require a move from schedule 1 to a CD schedule for drugs with medical use, i...
February 7, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29421753/occurrence-of-illicit-drugs-in-two-wastewater-treatment-plants-in-the-south-of-italy
#6
Alida Cosenza, Carmelo Massimo Maida, Donatella Piscionieri, Serena Fanara, Francesca Di Gaudio, Gaspare Viviani
In this study the occurrence and the behavior of illicit drugs and their metabolites have been investigated for two wastewater treatment plants (WWTPs) (namely, WWTP-1 and WWTP-2) located in Sicily (island of Italy). Samples were analyzed for methamphetamine, cocaine (COC), 3,4-methylenedioxymethamphetamine (MDMA), methadone (METH), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), 3,4-methylenedioxy amphetamine (MDA); 3,4-methylenedioxy ethylamphetamine (MDEA), 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) and Benzoylecgonine (BEG)...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29408729/analysis-of-illicit-drugs-seized-in-the-province-of-florence-from-2006-to-2016
#7
Elisabetta Bertol, Laura Bigagli, Stefano D'Errico, Francesco Mari, Diego Palumbo, Jennifer P Pascali, Fabio Vaiano
Comprehension of illicit drug market's features at local level is useful to plan and to correctly set-up specific informative and contrast activities. In this paper we report trends, purities and consumption estimations of illicit substances available on the Florentine territory from 2006 to 2016. These data were obtained by the analysis of 10,451 samples seized by the Law Enforcement Agencies in case of personal use offence. Analytical procedures consisted in targeted and untargeted analyses by gas chromatography-flame ionization detector, gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry...
February 2, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29406033/determination-and-long-term-stability-of-twenty-nine-cathinones-and-amphetamine-type-stimulants-ats-in-urine-using-gas-chromatography-mass-spectrometry
#8
Khalid A Alsenedi, Calum Morrison
A method was developed for the screening and quantification of seven amphetamine-type stimulants (ATS) and 22 cathinones, including three metabolites, in urine with Gas Chromatography-Mass Spectrometry. This method allowed the detection and quantification of ATS and cathinones group molecules using one procedure. A study of the stability of the drug mixtures for a period of 201 days in human urine samples under three different conditions has been carried. The ATS and cathinones include amphetamine, methamphetamine, MDA, MDEA, MDMA, PMA, PMMA, cathinone, methcathinone, 3'-position-substituted, ring-substituted, methylenedioxy-substituted, N-alkyl-substituted and pyrrolidinyl-substituted...
February 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29384873/acute-recreational-drug-toxicity-comparison-of-self-reports-and-results-of-immunoassay-and-additional-analytical-methods-in-a-multicenter-european-case-series
#9
Evangelia Liakoni, Christopher Yates, Alison M Dines, Paul I Dargan, Fridtjof Heyerdahl, Knut Erik Hovda, David M Wood, Florian Eyer, Matthias E Liechti
The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity.We performed a retrospective analysis of emergency department presentations of acute recreational drug toxicity over 2 years (October 2013 to September 2015) within the European Drug Emergencies Network Plus project.Among the 10,956 cases of acute recreational drug toxicity during the study period, 831 could be included. Between the self-reported substance use and the toxicological results, the highest agreement was found for heroin (86...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29378213/-ecstasy-to-addiction-mechanisms-and-reinforcing-effects-of-three-synthetic-cathinone-analogs-of-mdma
#10
Sean B Dolan, Zhenglan Chen, Renqi Huang, Michael B Gatch
This study aimed to address the mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA commonly reported in "Ecstasy" formulations: methylone, butylone, and pentylone. Whole-cell patch clamp techniques were used to assess the mechanism of each compound at the dopamine and serotonin transporters. Separate groups of rats were trained to discriminate methamphetamine, DOM, or MDMA from vehicle. Substitution studies were performed in each group and antagonism studies with SCH23390 were performed against each compound that produced substitution...
January 26, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29373879/ghrelin-alleviates-mdma-induced-disturbance-of-serum-glucose-and-lipids-levels-in-the-rat
#11
Ravieh Golchoobian, Fatemeh Nabavizadeh, Mehrdad Roghani, Alireza Foroumadi, Maryam Mohammadian
Hepatotoxicity is one of the clinically adverse effects of ecstasy (3, 4-methylenedioxymethamphetamine; MDMA) consumption. The detoxification tissue, liver, plays a central role in maintaining circulating levels of glucose and lipid. Hypoglycemia and hypotriglyceridemia have been reported due to ecstasy abuse. Ghrelin is a 28-amino-acid peptide secreted predominantly from the stomach. It has been demonstrated that ghrelin has hepatoprotective effects and is able to increase blood glucose concentration. In the current study, we explored the effect of hepatotoxic dose of MDMA and therapeutic use of exogenous ghrelin on the serum levels of glucose and lipids in four groups of rats...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29356590/taking-psychedelics-seriously
#12
Ira Byock
BACKGROUND: Psychiatric research in the 1950s and 1960s showed potential for psychedelic medications to markedly alleviate depression and suffering associated with terminal illness. More recent published studies have demonstrated the safety and efficacy of psilocybin, MDMA, and ketamine when administered in a medically supervised and monitored approach. A single or brief series of sessions often results in substantial and sustained improvement among people with treatment-resistant depression and anxiety, including those with serious medical conditions...
January 22, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29348651/depressive-mood-ratings-are-reduced-by-mdma-in-female-polydrug-ecstasy-users-homozygous-for-the-l-allele-of-the-serotonin-transporter
#13
K P C Kuypers, R de la Torre, M Farre, L Xicota, E B de Sousa Fernandes Perna, E L Theunissen, J G Ramaekers
MDMA exerts its main effects via the serotonergic system and the serotonin transporter. The gene coding for this transporter determines the expression rate of the transporter. Previously it was shown that healthy individuals with the short allelic variant ('s-group') of the 5-HTTLPR-polymorphism displayed more anxiety and negative mood, and had a lower transcriptional efficiency compared to individuals who are homozygous for the l-allele ('l-group'). The present study aimed to investigate the role of the 5-HTTLPR polymorphism in MDMA-induced mood effects...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29314761/keratinous-matrices-for-the-assessment-of-drugs-of-abuse-consumption-a-correlation-study-between-hair-and-nails
#14
Delphine Cappelle, Steven De Keukeleire, Hugo Neels, Frederic Been, Mireille De Doncker, Geert Dom, Cleo L Crunelle, Adrian Covaci, Alexander L N van Nuijs
Keratinous matrices - hair and nails - accumulate substances over time and allow retrospective investigation of past consumption. Analysis of these matrices can provide information complementary to blood and urine analysis or can be used as standalone. So far, research has primarily focused on the detection of substances in hair, while studies in nails are scarce. In this study, we assessed concentrations of drugs of abuse and their metabolites in hair, finger- and toenails collected from the same individuals to evaluate differences and correlations between matrices...
January 5, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29306167/wastewater-based-epidemiology-and-enantiomeric-profiling-for-drugs-of-abuse-in-south-african-wastewaters
#15
E Archer, E Castrignanò, B Kasprzyk-Hordern, G M Wolfaardt
The current study is aimed to introduce a wastewater-based epidemiology (WBE) approach for the first time on the African continent where substance abuse data is limited. The study included the quantification of several drugs of abuse (DOA) in raw wastewater samples. Quantification of urinary metabolites as drug target residues (DTR), as well as enantiomeric profiling of chiral DOA was performed to distinguish between consumption and direct disposal into sewage. Monitoring campaigns were undertaken at two South African wastewater treatment works (WWTWs) located within two provinces of the country...
January 3, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29303006/key-interindividual-determinants-in-mdma-pharmacodynamics
#16
E Papaseit, M Torrens, C Pérez-Mañá, R Muga, M Farré
MDMA, 3,4-methylenedioxymethamphetamine, is a synthetic phenethylamine derivative with structural and pharmacological similarities to both amphetamines and mescaline. MDMA produces characteristic amphetamine-like actions (euphoria, well-being), increases empathy, and induces pro-social effects that seem to motivate its recreational consumption and provide a basis for its potential therapeutic use. Areas covered: The aim of this review is to present the main interindividual determinants in MDMA pharmacodynamics...
January 5, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29295746/genuine-sildenafil-tablets-sold-in-brazil-disguised-as-mdma
#17
José Coelho Neto, Renata F P Faraco, Cíntia F Alves, Stela M M Castro, Yuri Machado
MDMA and sildenafil are two examples among many substances consumed in "raves", as well as in other types of "recreative" social events nowadays. During the first six months of 2017, five cases of supposedly MDMA tablets seized by local law enforcement forces in the state of Minas Gerais, Brazil, and brought to our forensic laboratory for examination, attracted our attention among dozens of others, as the tablets apprehended in these cases were, in fact, colorfully painted versions of genuine, pentagon-shaped, sildenafil tablets, freely available for sale in local pharmacies and drugstores...
December 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29291506/nonmedical-prescription-drug-use-among-african-americans-who-use-mdma-ecstasy-molly-implications-for-risk-reduction
#18
Khary K Rigg, Amanda Sharp
Recent data suggest that both nonmedical prescription drug and MDMA (ecstasy/molly) use have risen among African Americans. However, studies investigating these two forms of drug use among African Americans are rare. As a result, very little is known about African-American MDMA users and their nonmedical use of prescription medications. The primary goal of this study, therefore, was to describe patterns of nonmedical prescription drug use among African Americans who use MDMA. We also assessed alcohol and illicit drug use among the sample...
December 21, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29284546/medical-emergencies-related-to-ethanol-and-illicit-drugs-at-an-annual-nocturnal-indoor-electronic-dance-music-event
#19
Paul Calle, Nora Sundahl, Kristof Maudens, Sarah Mr Wille, Diederik Van Sassenbroeck, Koen De Graeve, Stefan Gogaert, Peter De Paepe, Dieter Devriese, Geert Arno, Peter Blanckaert
Introduction Medical problems are frequently encountered during electronic dance music (EDM) events. Problem There are uncertainties about the frequencies and severity of intoxications with different types of recreational drugs: ethanol, "classical" illicit party drugs, and new psychoactive substances (NPS). METHODS: Statistical data on the medical problems encountered during two editions of an indoor electronic dance event with around 30,000 attendants were retrieved from the Belgian Red Cross (Mechelen, Belgium) database...
December 29, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29248945/-%C3%A2-mdma-and-its-enantiomers-potential-therapeutic-advantages-of-r-mdma
#20
REVIEW
Elizabeth G Pitts, Daniel W Curry, Karly N Hampshire, Matthew B Young, Leonard L Howell
The use of (±)-3,4-methylenedioxymethamphetamine ((±)-MDMA) as an adjunct to psychotherapy in the treatment of psychiatric and behavioral disorders dates back over 50 years. Only in recent years have controlled and peer-reviewed preclinical and clinical studies lent support to (±)-MDMA's hypothesized clinical utility. However, the clinical utility of (±)-MDMA is potentially mitigated by a range of demonstrated adverse effects. One potential solution could lie in the individual S(+) and R(-) enantiomers that comprise (±)-MDMA...
December 16, 2017: Psychopharmacology
keyword
keyword
672
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"