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Saccharomyces boulardii

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https://www.readbyqxmd.com/read/27925366/oral-administration-of-saccharomyces-boulardii-alters-duodenal-morphology-enzymatic-activity-and-cytokine-production-response-in-broiler-chickens
#1
Yajing Sun, Imran Rashid Rajput, Muhammad Asif Arain, Yanfei Li, Dost Muhammad Baloch
The present study evaluated the effects of Saccharomyces boulardii on duodenal digestive enzymes, morphology and cytokine induction response in broiler chicken. A total of 200 birds were allotted into two groups (n = 100) and each group divided into five replications (n = 20). The control group was fed basal diet in addition to antibiotic (virginiamycin 20 mg/kg), and treatment group received (1 × 10(8)  colony-forming units/kg feed) S. boulardii in addition to basal diet lasting for 72 days. The results compared to control group revealed that adenosine triphosphatase, gamma glutamyl transpeptidase, lipase and trypsin activities were higher, while, no significant improvement was observed in amylase activities in the duodenum of the treatment group...
December 7, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27898740/kluyveromyces-marxianus-and-saccharomyces-boulardii-induce-distinct-levels-of-dendritic-cell-cytokine-secretion-and-significantly-different-t-cell-responses-in-vitro
#2
Ida M Smith, Adam Baker, Jeffrey E Christensen, Teun Boekhout, Hanne Frøkiær, Nils Arneborg, Lene Jespersen
Interactions between members of the intestinal microbiota and the mucosal immune system can significantly impact human health, and in this context, fungi and food-related yeasts are known to influence intestinal inflammation through direct interactions with specialized immune cells in vivo. The aim of the present study was to characterize the immune modulating properties of the food-related yeast Kluyveromyces marxianus in terms of adaptive immune responses indicating inflammation versus tolerance and to explore the mechanisms behind the observed responses...
2016: PloS One
https://www.readbyqxmd.com/read/27878744/protective-effect-of-saccharomyces-boulardii-on-deoxynivalenol-induced-injury-of-porcine-macrophage-via-attenuating-p38-mapk-signal-pathway
#3
Chao Chang, Kun Wang, Sheng-Nan Zhou, Xue-Dong Wang, Jin-E Wu
The aims of our study were to evaluate the effects of Saccharomyces boulardii (S. boulardii) on deoxynivalenol (DON)-induced injury in porcine alveolar macrophage cells (PAMCs) and to explore the underlying mechanisms. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometric analysis, ELISA, qRT-PCR, and western blot were performed to assess whether S. boulardii could prevent DON-induced injury by p38 mitogen-activated protein kinase (p38 MAPK) signal pathway. The results showed that pretreatment with 8 μM DON could decrease the viability of PAMC and significantly increase the apoptosis rate of PAMC, whereas S...
November 23, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27868205/antioxidant-properties-and-global-metabolite-screening-of-the-probiotic-yeast-saccharomyces-cerevisiae-var-boulardii
#4
Suprama Datta, David J Timson, Uday S Annapure
BACKGROUND: Saccharomyces cerevisiae var. boulardii is the only yeast species with probiotic properties. It is considered to have therapeutic significance in gastro-intestinal disorders. In this paper, a comparative physiological study between this yeast and Saccharomyces cerevisiae (BY4742) was performed by evaluating two prominent traits of probiotic species, responses to different stress conditions and antioxidant capacity. A global metabolite profile was also developed in order to identify which therapeutically important secondary metabolites are produced...
November 21, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27790616/a-comprehensive-comparison-of-the-efficacy-and-tolerability-of-racecadotril-with-other-treatments-of-acute-diarrhea-in-adults
#5
REVIEW
Wolfgang Fischbach, Viola Andresen, Marion Eberlin, Tobias Mueck, Peter Layer
Racecadotril is a guideline-recommended treatment to alleviate symptoms of acute diarrhea. A systematic review of randomized studies was performed comparing efficacy and safety of treatment with racecadotril to that with placebo or active treatments in adults. In five double-blind studies, racecadotril and placebo had comparable tolerability, but racecadotril was more effective. This was consistent across multiple efficacy parameters including duration of diarrhea, number of diarrheic stools, abdominal pain, and meteorism; it was also consistent across countries in Africa, Asia, and Europe...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27732755/ochratoxin-a-removal-by-yeasts-after-exposure-to-simulated-human-gastrointestinal-conditions
#6
Leonardo Petruzzi, Maria Rosaria Corbo, Milena Sinigaglia, Antonio Bevilacqua
Yeasts can remove ochratoxin A (OTA) in foods; however, we do not know if they can experience this ability in the gut. Thus, the aim of this paper was to study OTA binding by 3 wine strains of Saccharomyces cerevisiae (W13, W28, and the commercial isolate BM45) and S. cerevisiae var. boulardii ATCC MYA-796 (a probiotic yeast) after exposure to conditions simulating the passage through human gastrointestinal tract. Yeasts removed OTA by up to 44%, with a better ability found after gastrointestinal and sequential assays...
October 12, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27702472/evaluation-of-cysteine-ethyl-ester-as-efficient-inducer-for-glutathione-overproduction-in-saccharomyces-spp
#7
Eric Lorenz, Maximilian Schmacht, Martin Senz
Economical yeast based glutathione (GSH) production is a process that is influenced by several factors like raw material and production costs, biomass production and efficient biotransformation of adequate precursors into the final product GSH. Nowadays the usage of cysteine for the microbial conversion into GSH is industrial state of practice. In the following study, the potential of different inducers to increase the GSH content was evaluated by means of design of experiments methodology. Investigations were executed in three natural Saccharomyces strains, S...
November 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27696378/probiotics-fiber-and-herbal-medicinal-products-for-functional-and-inflammatory-bowel-disorders
#8
Diego Currò, Gianluca Ianiro, Silvia Pecere, Stefano Bibbò, Giovanni Cammarota
Functional bowel disorders (FBDs), mainly irritable bowel syndrome (IBS) and functional constipation (FC, also called chronic idiopathic constipation), are highly diffused worldwide. Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, although less common, has a strong impact on patients' quality of life, as well as is highly expensive for our healthcare. A definite cure for those disorders is still yet to come. Over the years, several therapeutic approaches complementary or alternative to traditional pharmacological treatments, including probiotics, prebiotics, synbiotics, fiber and herbal medicinal products, have been investigated for the management of both groups of diseases...
October 3, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27695355/influence-of-saccharomyces-boulardii-cncm-i-745on-the-gut-associated-immune-system
#9
Heike Stier, Stephan C Bischoff
BACKGROUND: The probiotic Saccharomyces boulardii CNCM I-745 (also known as Saccharomyces cerevisiae HANSEN CBS 5926; in the following S. boulardii) has proven its effectiveness in preventive and therapeutic treatment of many gastrointestinal diseases, especially diseases associated with acute diarrhea. In particular, antibiotic-associated diarrhea, Clostridium difficile-associated diarrhea, traveller's diarrhea, as well as acute diarrhea due to common viral and bacterial infections in children and adults...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27688016/probiotics-for-the-prevention-of-pediatric-antibiotic-associated-diarrhea
#10
Shelby R Hayes, Ashley J Vargas
: Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, Johnston BC. Probiotics for the prevention of pediatric antibiotic-associated diarrhea.Cochrane Database Syst Rev2015, Issue 12. Art. No.: CD004827. http://dx.doi.org/10.1002/14651858.CD004827.pub4. BACKGROUND: Antibiotics are frequently prescribed in children. They alter the microbial balance within the gastrointestinal tract, commonly resulting in antibiotic-associated diarrhea (AAD). Probiotics may prevent AAD via restoration of the gut microflora...
November 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/27530282/the-effect-of-a-yeast-probiotic-on-acute-diarrhea-in-children
#11
Mohammad Reza Sharif, Hamed Haddad Kashani, Abbas Taghavi Ardakani, Davood Kheirkhah, Fatemeh Tabatabaei, Alireza Sharif
A probiotic is a living micro-organism administered to promote the health of the host by treating or preventing infections owing to strains of pathogens. Saccharomyces boulardii is a nonpathogen yeast that has a direct inhibitory effect on the growth of many pathogens, an anti-secretory effect and a trophic effect on enterocytes. The aim of this study was to determine the effect of S. boulardii on diarrhea in children. The children from 6 months to 6 years of age with acute watery diarrhea admitted in pediatric clinic in Kashan in 2012 were included in this trial...
August 16, 2016: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/27514478/probiotic-saccharomyces-boulardii-cncm-i-745-prevents-outbreak-associated-clostridium-difficile-associated-cecal-inflammation-in-hamsters
#12
Hon Wai Koon, Bowei Su, Chunlan Xu, Caroline C Mussatto, Diana Hoang-Ngoc Tran, Elaine C Lee, Christina Ortiz, Jiani Wang, Jung Eun Lee, Samantha Ho, Xinhua Chen, Ciaran P Kelly, Charalabos Pothoulakis
C. difficile infection (CDI) is a common debilitating nosocomial infection associated with high mortality. Several CDI outbreaks have been attributed to ribotypes 027, 017, and 078. Clinical and experimental evidence indicates that the nonpathogenic yeast Saccharomyces boulardii CNCM I-745 (S.b) is effective for the prevention of CDI. However, there is no current evidence suggesting this probiotic can protect from CDI caused by outbreak-associated strains. We used established hamster models infected with outbreak-associated C...
October 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27430508/in-vitro-investigation-of-debaryomyces-hansenii-strains-for-potential-probiotic-properties
#13
Honeylet Sabas Ochangco, Amparo Gamero, Ida M Smith, Jeffrey E Christensen, Lene Jespersen, Nils Arneborg
In this study, 23 Debaryomyces hansenii strains, isolated from cheese and fish gut, were investigated in vitro for potential probiotic properties i.e. (1) survival under in vitro GI (gastrointestinal) conditions with different oxygen levels, (2) adhesion to Caco-2 intestinal epithelial cells and mucin, and (3) modulation of pro- and anti-inflammatory cytokine secretion by human monocyte-derived dendritic cells. As references two commercially available probiotic Saccharomyces cerevisiae var. boulardii (S. boulardii) strains were included in the study...
September 2016: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27283364/efficacy-and-safety-of-saccharomyces-boulardii-in-acute-rotavirus-diarrhea-double-blind-randomized-controlled-trial-from-a-developing-country
#14
Susrut Das, Pradeep Kumar Gupta, Rashmi Ranjan Das
OBJECTIVE: To study the efficacy and safety of Saccharomyces boulardii (SB) in acute childhood rotavirus diarrhea. METHODS: Children (3 months to 5 years) with WHO-defined acute watery diarrhea and stool rotavirus positive (n  =  60) were randomized into intervention (n  =  30) and control (n  =  30) groups. The intervention group received SB (500 mg/day) for 5 days. RESULTS: The median duration (hours) of diarrhea was significantly shorter in the intervention group (60 vs...
June 9, 2016: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/27250926/probiotic-yeast-saccharomyces-boulardii-nom-nud-modulates-adhesive-properties-of-candida-glabrata
#15
Zorica Tomičić, Jure Zupan, Tadeja Matos, Peter Raspor
Following the widespread use of immunosuppressive therapy together with broad-spectrum antimycotic therapy, the frequency of mucosal and systemic infections caused by the pathogenic yeast Candida glabrata has increased in the past decades. Due to the resistance of C. glabrata to existing azole drugs, it is very important to look for new strategies helping the treatment of such fungal diseases. In this study, we investigated the effect of the probiotic yeast Saccharomyces boulardii (nom. nud.) on C. glabrata adhesion at different temperatures, pH values, and in the presence of fluconazole, itraconazole and amphotericin B...
November 1, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27067538/effect-of-topically-applied-saccharomyces-boulardii-on-the-healing-of-acute-porcine-wounds-a-preliminary-study
#16
Jessica Partlow, Anthony Blikslager, Charles Matthews, Mac Law, Joshua Daniels, Rose Baker, Raphael Labens
BACKGROUND: Normal wound healing progresses through a series of interdependent physiological events: inflammation, angiogenesis, re-epithelialization, granulation tissue formation and extracellular matrix remodeling. Alterations in this process as well as the bacterial type and load on a wound may alter the wound healing rate. The purpose of this study was to evaluate the effect of topical Saccharomyces boulardii on the healing of acute cutaneous wounds, using a prospective, controlled, experimental study, with six purpose bred landrace pigs...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27064405/characterization-of-the-probiotic-yeast-saccharomyces-boulardii-in-the-healthy-mucosal-immune-system
#17
Lauren E Hudson, Courtney D McDermott, Taryn P Stewart, William H Hudson, Daniel Rios, Milo B Fasken, Anita H Corbett, Tracey J Lamb
The probiotic yeast Saccharomyces boulardii has been shown to ameliorate disease severity in the context of many infectious and inflammatory conditions. However, use of S. boulardii as a prophylactic agent or therapeutic delivery vector would require delivery of S. boulardii to a healthy, uninflamed intestine. In contrast to inflamed mucosal tissue, the diverse microbiota, intact epithelial barrier, and fewer inflammatory immune cells within the healthy intestine may all limit the degree to which S. boulardii contacts and influences the host mucosal immune system...
2016: PloS One
https://www.readbyqxmd.com/read/27028756/probiotic-bacterial-and-fungal-strains-claims-with-evidence
#18
Hania Szajewska, Zofia Konarska, Maciej Kołodziej
BACKGROUND: Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit for the host. This review summarizes current (i.e. published in the last 5 years) key evidence on probiotic efficacy and its safety in adults and children. To identify relevant data, searches of MEDLINE and the Cochrane Library databases were performed in August 2015 to locate randomized controlled trials (RCTs) or their meta-analyses. The focus was on commonly used, well-specified, bacterial and yeast probiotics for the treatment of gastrointestinal disorders...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/26973849/saccharomyces-boulardii-to-prevent-antibiotic-associated-diarrhea-a-randomized-double-masked-placebo-controlled-trial
#19
Stephan Ehrhardt, Nan Guo, Rebecca Hinz, Stefanie Schoppen, Jürgen May, Markus Reiser, Maximilian Philipp Schroeder, Stefan Schmiedel, Martin Keuchel, Emil C Reisinger, Andreas Langeheinecke, Andreas de Weerth, Marcus Schuchmann, Tom Schaberg, Sandra Ligges, Maria Eveslage, Ralf M Hagen, Gerd D Burchard, Ansgar W Lohse
Background.  Antibiotic-associated diarrhea (AAD) and Clostridium difficile-associated diarrhea (CDAD) are common complications of antibiotic use. Data on the efficacy of probiotics to prevent AAD and CDAD are unclear. We aimed to evaluate the efficacy of Saccharomyces boulardii to prevent AAD and CDAD in hospitalized adult patients. Methods.  We conducted a multicenter, phase III, double-masked, randomized, placebo-controlled trial in hospitalized patients who received systemic antibiotic treatment in 15 hospitals in Germany between July 2010 and October 2012...
January 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/26971490/modulation-of-il-12-and-ifn%C3%AE-by-probiotic-supplementation-promotes-protection-against-toxocara-canis-infection-in-mice
#20
L F D C de Avila, P M M de Leon, M Q de Moura, M E A Berne, C J Scaini, F P Leivas Leite
In this study, supplementation with the probiotic Saccharomyces boulardii promoted a reduction in intensity of infection by Toxocara canis and modulates cytokines mRNA expression in experimentally infected mice. IL-12 gene transcription had 40-fold increase in S. boulardii supplemented uninfected mice and sevenfold increase in supplemented infected mice comparing with not supplemented group. Regarding IFNγ, similar results were observed, since probiotic supplementation induced approximately 43-fold increase, but only in uninfected mice (P < 0·05)...
May 2016: Parasite Immunology
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