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https://www.readbyqxmd.com/read/29453876/prognostic-importance-of-fgf2-and-fgfr1-expression-for-patients-affected-by-ameloblastoma
#1
Felipe Paiva Fonseca, Bernar Monteiro Benites, Ciro Dantas Soares, Thayná Melo de Lima Morais, Gleyson Kleber do Amaral-Silva, Oslei Paes de Almeida, Fernando Augusto Soares, Eduardo Rodrigues Fregnani
BACKGROUND: Fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1) have been investigated in different human neoplasms and were shown to play important roles in the pathogenesis of these diseases; however, very few is known regarding their prognostic importance in the context of ameloblastoma. Therefore, the aim of this study is to investigate if the expression of FGF2 and FGFR1 is associated with ameloblastoma clinical behavior. METHODS: Fifty-eight cases of ameloblastoma arranged in tissue microarray were submitted to immunohistochemistry against FGF2 and FGFR1...
February 17, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29442350/occult-phosphaturic-mesenchymal-tumor-of-femur-cortex-causing-oncogenic-osteomalacia-diagnostic-challenges-and-clinical-outcomes
#2
Deep Dutta, Raghuvansh Kumar Pandey, Rakhee Gogoi, Nagender Solanki, Renu Madan, Anupam Mondal, Shruti Dogra, Pradeep Thapa
BACKGROUND: Tumor induced osteomalacia (TIO) are extremely rare paraneoplastic syndrome with less than 300 reported cases. This report highlights the pitfalls and challenges in diagnosing and localizing TIO in patients with refractory and resistant osteomalacia. PATIENT AND METHODS: 41- year gentleman with 4-year history of musculoskeletal weakness and pathologic fractures presented in wheelchair bound incapacitated state of 1-year duration. Investigations were significant for severe hypophosphatemia, severe phosphaturia, normal serum calcium, reduced 1,25-dihydroxy vitamin-D, elevated ALP, elevated intact parathyroid hormone (iPTH), and pseudo-fractures involving pelvis and bilateral femur...
February 14, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29435025/bromelain-has-significant-clinical-benefits-after-extraction-of-the-third-molar-during-chemotherapy-in-patients-with-hematologic-tumor
#3
Yi Tan, Ping Li
The purpose of this study was to investigate the application of bromelain in the treatment of pain, swelling, and limited mouth opening in patients with hematologic tumor after extraction of the third molar during chemotherapy. We recruited 72 patients with hematologic tumor who were treated by oral and maxillofacial surgery in our hospital, and third molar extraction was performed under local anesthesia. After extraction, patients in the control group were treated with cold - hot compress and patients in the experimental group were treated by oral administration of bromelain...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29367522/low-plasma-levels-of-fibroblast-growth-factor-21-in-patients-with-peripheral-artery-disease
#4
Yoshichika Miyazaki, Emi Saita, Yoshimi Kishimoto, Susumu Ibe, Toshiki Seki, Kotaro Miura, Norie Suzuki-Sugihara, Yukinori Ikegami, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama
AIM: Fibroblast growth factor-21 (FGF-21) is a metabolic regulator with beneficial effects on glucolipid metabolism. Since FGF-21 has lipid-lowering, anti-inflammatory and anti-oxidant properties, it may play a protective role against atherosclerosis. However, blood FGF-21 levels in coronary artery disease (CAD) or peripheral artery disease (PAD) have not been elucidated. METHODS: We measured plasma FGF-21 levels in 417 patients undergoing coronary angiography, who also had ankle-brachial index test for PAD screening...
January 24, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29363048/association-of-serum-betatrophin-with-fibroblast-growth-factor-21-in-women-with-polycystic-ovary-syndrome
#5
S Kahraman, A E Altinova, M M Yalcin, O Gulbahar, B Arslan, M Akturk, N Cakir, F B Toruner
PURPOSE: Betatrophin and fibroblast growth factor-21 (FGF-21), which are recently discovered members of hepatokine/adipokine family, have been proposed to be associated with some metabolic disorders in which insulin resistance plays a major role. METHODS: We aimed to investigate serum betatrophin and FGF-21 concentrations in women with polycystic ovary syndrome (PCOS). In this cross-sectional study, we recruited 31 women with PCOS and 34 women as healthy controls...
January 23, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29317227/prolonged-exposure-to-1-25-oh-2d3-and-high-ionized-calcium-induces-fgf-23-production-in-intestinal-epithelium-like-caco-2-monolayer-a-local-negative-feedback-for-preventing-excessive-calcium-transport
#6
Mayuree Rodrat, Kannikar Wongdee, Nattapon Panupinthu, Jirawan Thongbunchoo, Jarinthorn Teerapornpuntakit, Nateetip Krishnamra, Narattaphol Charoenphandhu
Overdose of oral calcium supplement and excessive intestinal calcium absorption can contribute pathophysiological conditions, e.g., nephrolithiasis, vascular calcification, dementia, and cardiovascular accident. Since our previous investigation has indicated that fibroblast growth factor (FGF)-23 could abolish the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]-enhanced calcium absorption, we further hypothesized that FGF-23 produced locally in the enterocytes might be part of a local negative feedback loop to regulate calcium absorption...
January 6, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29282520/tgf%C3%AE-counteracts-lyve-1-mediated-induction-of-lymphangiogenesis-by-small-hyaluronan-oligosaccharides
#7
Jochen Bauer, Melanie Rothley, Anja Schmaus, Luca Quagliata, Markus Ehret, Moritz Biskup, Véronique Orian-Rousseau, David G Jackson, Ronald J Pettis, Alfred Harvey, Stefan Bräse, Wilko Thiele, Jonathan P Sleeman
During tissue injury, inflammation, and tumor growth, enhanced production and degradation of the extracellular matrix glycosaminoglycan hyaluronan (HA) can lead to the accumulation of small HA (sHA) oligosaccharides. We have previously reported that accumulation of sHA in colorectal tumors correlates with lymphatic invasion and lymph node metastasis, and therefore, investigated here are the effects of sHA on the lymphatic endothelium. Using cultured primary lymphatic endothelial cells (LECs) and ex vivo and in vivo lymphangiogenesis assays, we found that in contrast to high-molecular-weight HA (HMW-HA), sHA of 4-25 disaccharides in length can promote the proliferation of LECs and lymphangiogenesis in a manner that is dependent on their size and concentration...
December 27, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29238880/in-vitro-performance-of-prefilled-co2-absorbers-with-the-zeus%C3%A2
#8
Mohab Omer, Jan F A Hendrickx, Simon De Ridder, Alexander De Houwer, Rik Carette, Sofie De Cooman, Andre M De Wolf
Low fresh gas flows (FGFs) decrease the use of anesthetic gases, but increase CO2 absorbent usage. CO2 absorbent usage remains poorly quantified. The goal of this study is to determine canister life of 8 commercially available CO2 absorbent prepacks with the Zeus®. Pre-packed CO2 canisters of 8 different brands were tested in vitro: Amsorb Plus, Spherasorb, LoFloSorb, LithoLyme, SpiraLith, SpheraSorb, Drägersorb 800+, Drägersorb Free, and CO2ntrol. CO2 (160 mL min- 1) flowed into the tip of a 2 L breathing bag that was ventilated with a tidal volume of 500 mL, a respiratory rate of 10/min, and an I:E ratio of 1:1 using the controlled mechanical ventilation mode of the Zeus® (Dräger, Lubeck, Germany)...
December 13, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29189197/hr-pqct-detects-alterations-in-bone-microstructure-in-men-with-ckd-stages-3-and-4-which-are-influenced-by-hormonal-changes-and-body-composition%C3%A2
#9
Francisco P Paranhos-Neto, Guilherme A C Lima, Luciana C Silva, Miguel Madeira, Leonardo Vieira Neto, Laura M C Mendonça, Inayá C B Lima, Alvimar G Delgado, Maurilo Leite, Carlos P Gomes, Maria Lucia F Farias
INTRODUCTION: Factors associated with osteodystrophy in predialysis patients are poorly understood. In the present study, we attempted to evaluate the impact of body composition and hormonal regulatory factors on the bone microstructure in a group of men with chronic kidney disease (CKD) stages 3 and 4. MATERIALS AND METHODS: 46 men, aged 50 - 75 years, with previously unrecognized CKD were evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT), and dual-energy X-ray absorptiometry (DXA)...
November 30, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29179169/-bone-remodeling-through-a-phosphate-metabolism
#10
Takeshi Miyamoto
Phosphorus is the second abundant mineral stored in bones, and disturbance of phosphate metabolisms results in various disease developments such as hypophosphatemic rickets. Blood phosphorus levels are regulated by dietary intake or its absorption from intestine, proximal tubular reabsorption, and number of factors plays roles for maintaining phosphate homeostasis. Vitamin D stimulates intestinal phosphorus absorption, and phosphorus promotes FGF23 secretion from osteocytes. FGF23 inhibits Cyp27b1, an enzyme to produce an active vitamin D3, 1,25(OH)2D3, through FGF receptor/Klotho complex...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29149966/seasonal-variation-of-vitamin-d-status-in-long-term-kidney-transplant-recipients
#11
J Wilimborek, M Nowicki, I Kurnatowska
BACKGROUND: There is little information about circannual rhythm of vitamin D level in kidney transplantation (KTx) patients. MATERIAL AND METHODS: In 71 patients (27 females; 44 males) in the long term after KTx (5.5 ± 2.6 years) during the winter and summer months plasma concentration of 25-hydroxyvitamin D (25(OH)D), 1,25-hydroxyvitamin D, parathormone (PTH), fibroblast growth factor 23 (FGF-23), calcium, and phosphorus were assessed. Vitamin D status was classified according to 25(OH)D level (ie, insufficiency, ≤30 ng/mL; deficiency, <15 ng/mL)...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29121251/protective-effect-of-fgf-2-and-low-molecular-weight-heparin-protamine-nanoparticles-on-radiation-induced-healing-impaired-wound-repair-in-rats
#12
Jun Kinoda, Masayuki Ishihara, Shingo Nakamura, Masanori Fujita, Koichi Fukuda, Yoko Sato, Hidetaka Yokoe
We examined the effectiveness of localized administration of fibroblast growth factor-2 containing low-molecular-weight heparin/protamine nanoparticles (FGF-2&LMWH/P NPs) on apoptosis in vivo and on healing of radiation-induced skin injury in a rat model. FGF-2 binds onto LMWH/P NPs, which can significantly enhance and stabilize FGF-2 as a local carrier. X-irradiation at a dose of 25 Gy was administered to the lower part of the back (using a lead sheet with two holes) 1 h before the administration of FGF-2&LMWH/P NPs...
November 7, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29026610/selective-blood-sampling-for-fgf-23-in-tumor-induced-osteomalacia
#13
Hans-Christof Schober, Christian Kneitz, Franziska Fieber, Kathrin Hesse, Henry Schroeder
Tumor-induced osteomalacia (TIO) is caused by the hormone fibroblast growth factor 23 (FGF-23). It is mainly produced in the tissue of mesenchymal tumors. Patients with TIO frequently suffer from a chronic decompensated pain syndrome and/or muscle weakness with postural deformity. Despite the severity of the disease, the diagnosis is frequently established late. In some cases, it takes several years to establish the condition. This case report concerning a 68-year old woman demonstrates the selective blood sampling for FGF-23 as path-breaking diagnostics to confirm the diagnosis of a neuroendocrine tumor...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29021814/sex-specific-association-between-fibroblast-growth-factor-21-and-type-2-diabetes-a-nested-case-control-study-in-singapore-chinese-men-and-women
#14
Yeli Wang, Woon-Puay Koh, Jian-Min Yuan, An Pan
BACKGROUND: Fibroblast growth factor 21 (FGF-21) is mainly secreted by liver and has been reported to be involved in the pathogenesis of type 2 diabetes. Some prospective studies have shown a positive association between FGF-21 and diabetes risk. However, no study has examined whether the association differed by sex, which has been reported between FGF-21 and atherosclerosis. Therefore, we prospectively evaluated the sex-specific association between FGF-21 and diabetes in a Chinese population...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28939209/calcium-and-bone-metabolism-indices
#15
Lu Song
Calcium and inorganic phosphate are of critical importance for many body functions, thus the regulations of their plasma concentrations are tightly controlled by the concerted actions of reabsorption/excretion in the kidney, absorption in the intestines, and exchange from bone, the major reservoir for calcium and phosphate in the body. Parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (1,25(OH)2D) control calcium homeostasis, whereas PTH, 1,25(OH)2D, and bone-derived fibroblast growth factor 23 (FGF 23) control phosphate homeostasis...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28872612/fructus-ligustri-lucidi-in-osteoporosis-a-review-of-its-pharmacology-phytochemistry-pharmacokinetics-and-safety
#16
REVIEW
Beibei Chen, Lili Wang, Lin Li, Ruyuan Zhu, Haixia Liu, Chenyue Liu, Rufeng Ma, Qiangqiang Jia, Dandan Zhao, Jianzhao Niu, Min Fu, Sihua Gao, Dongwei Zhang
Background: Fructus Ligustri Lucidi (FLL) has now attracted increasing attention as an alternative medicine in the prevention and treatment of osteoporosis. This study aimed to provide a general review of traditional interpretation of the actions of FLL in osteoporosis, main phytochemical constituents, pharmacokinetics, pharmacology in bone improving effect, and safety. Materials and Methods: Several databases, including PubMed, China National Knowledge Infrastructure, National Science and Technology Library, China Science and Technology Journal Database, and Web of Science were consulted to locate publications pertaining to FLL...
September 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28870993/klf5-maintains-the-balance-of-primitive-endoderm-versus-epiblast-specification-during-mouse-embryonic-development-by-suppression-of-fgf4
#17
Takuya Azami, Tsuyoshi Waku, Ken Matsumoto, Hyojung Jeon, Masafumi Muratani, Akihiro Kawashima, Jun Yanagisawa, Ichiro Manabe, Ryozo Nagai, Tilo Kunath, Tomonori Nakamura, Kazuki Kurimoto, Mitinori Saitou, Satoru Takahashi, Masatsugu Ema
The inner cell mass of the mouse blastocyst gives rise to the pluripotent epiblast (EPI), which forms the embryo proper, and the primitive endoderm (PrE), which forms extra-embryonic yolk sac tissues. All inner cells coexpress lineage markers such as Nanog and Gata6 at embryonic day (E) 3.25, and the EPI and PrE precursor cells eventually segregate to exclusively express Nanog and Gata6, respectively. Fibroblast growth factor (FGF)-extracellular signal-regulated kinase (ERK) signalling is involved in segregation of the EPI and PrE lineages; however, the mechanism involved in Fgf4 regulation is poorly understood...
October 15, 2017: Development
https://www.readbyqxmd.com/read/28846459/calcifediol-to-treat-secondary-hyperparathyroidism-in-patients-with-chronic-kidney-disease
#18
REVIEW
Andrea Galassi, Antonio Bellasi, Paola Ciceri, Francesca Pivari, Ferruccio Conte, Mario Cozzolino
Deranged vitamin D metabolism represents an active trigger of secondary hyperparathyroidism (SHPT) in CKD. Correction of 25(OH)D deficiency by nutritional Vitamin D administration is suggested by KDIGO guidelines, to prevent and treat SHPT in CKD stage G3-G5 and G1T-G5T patients, although with a still inconsistent background. Nutritional vitamin D is available as cholecalciferol, ergocalciferol, or calcifediol. Superiority of calcifediol in increasing 25(OH)D levels has been suggested due to its better bioavailability...
October 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28752189/impact-of-tissue-based-genomic-profiling-on-clinical-decision-making-in-the-management-of-patients-with-metastatic-breast-cancer-at-academic-centers
#19
Cesar A Santa-Maria, Megan Kruse, Paola Raska, Mia Weiss, April Swoboda, Martin B Mutonga, Jame Abraham, Sarika Jain, Rita Nanda, Alberto J Montero
BACKGROUND: Genomic profiling can identify targetable mutations; however, the impact of tissue-based genomic profiling on clinical decision making for patients with metastatic breast cancer has not been well characterized. METHODS: Patients with stage IV breast cancer who had undergone genomic profiling between 7/2013 and 3/2015 were identified at three academic cancer centers. Genomic analysis was determined to have impacted clinical decision if (A) a patient was enrolled onto a genotype-matched clinical trial or (B) prescribed off-label an FDA-approved therapy targeting an identified mutation...
July 27, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28724055/bone-turnover-after-bariatric-surgery
#20
Thalita Lima Melo, Leila Froeder, Leandro da Cunha Baia, Ita Pfeferman Heilberg
OBJECTIVE: The aim of the present study was to evaluate parameters of bone and mineral metabolism after bariatric surgery. SUBJECTS AND METHODS: This sectional study included data from medical records from 61 bariatric surgery (BS) patients (minimum period of 6 months after the procedure) and from 30 class II and III obese patients as a control group (Cont), consisting of daily dietary intake of macronutrients, calcium and sodium, serum 25(OH)D and parathyroid hormone (PTH) and other biochemical serum and urinary parameters...
July 2017: Archives of Endocrinology and Metabolism
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