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Muscle molecular metabolism

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https://www.readbyqxmd.com/read/28813489/oxidative-and-glycolytic-skeletal-muscles-show-marked-differences-in-gene-expression-profile-in-chinese-qingyuan-partridge-chickens
#1
Shu Jingting, Xiao Qin, Shan Yanju, Zhang Ming, Tu Yunjie, Ji Gaige, Sheng Zhongwei, Zou Jianmin
Oxidative and glycolytic myofibers have different structures and metabolic characteristics and their ratios are important in determining poultry meat quality. However, the molecular mechanisms underlying their differences are unclear. In this study, global gene expression profiling was conducted in oxidative skeletal muscle (obtained from the soleus, or SOL) and glycolytic skeletal muscle (obtained from the extensor digitorum longus, or EDL) of Chinese Qingyuan partridge chickens, using the Agilent Chicken Gene Expression Chip...
2017: PloS One
https://www.readbyqxmd.com/read/28810820/quantitative-label-free-evaluation-of-tissue-engineered-skeletal-muscle-through-multiphoton-microscopy
#2
Brian C Syverud, Mary-Ann Mycek, Lisa Marie Larkin
The lack of tools for assessing engineered tissue viability and function in a non-invasive manner is a major regulatory and translational challenge facing tissue engineers. Label-free, nonlinear optical molecular imaging (OMI) has utilized endogenous nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) fluorescence to indicate metabolic activity. Similarly, second harmonic generation (SHG) signals from myosin and collagen can measure overall muscle structural integrity and function...
August 16, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28810121/comparative-proteomic-and-transcriptomic-analysis-of-follistatin-induced-skeletal-muscle-hypertrophy
#3
Caroline Barbé, Fabrice Bray, Marine Gueugneau, Stéphanie Devassine, Pascale Lause, Caroline Tokarski, Christian Rolando, Jean-Paul Thissen
Skeletal muscle, the most abundant body's tissue, plays vital roles in locomotion and metabolism. Myostatin is a negative regulator of skeletal muscle mass. In addition to increase muscle mass, Myostatin inhibition impacts on muscle contractility and energy metabolism. To decipher the mechanisms of action of the Myostatin inhibitors, we used proteomic and transcriptomic approaches to investigate the changes induced in skeletal muscles of transgenic mice overexpressing Follistatin, a physiological Myostatin inhibitor...
August 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28802226/taraxerol-a-pentacyclic-triterpenoid-from-abroma-augusta-leaf-attenuates-diabetic-nephropathy-in-type-2-diabetic-rats
#4
Ritu Khanra, Niloy Bhattacharjee, Tarun K Dua, Ashis Nandy, Achintya Saha, Jatin Kalita, Prasenjit Manna, Saikat Dewanjee
Persistent hyperglycaemia coupled with inflammation plays an important role in the pathogenesis of diabetic nephropathy (DN). Present study examined the therapeutic potential of taraxerol isolated from the methanol extract of Abroma augusta leaf against DN using rodent model of type 2 diabetes (T2D). T2D was experimentally induced by high fat diet and a single low-single dose of streptozotocin (35mg/kg, i.p.). Accumulation of serum creatinine, urea, and uric acid, activation of lactate dehydrogenase and creatinin kinase, and release of urinary albumin represented the glomerular damage and the progression of nephropathy in T2D rats...
August 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28800433/global-gene-expression-analysis-of-the-muscle-tissues-of-medaka-acclimated-to-low-and-high-environmental-temperatures
#5
Daisuke Ikeda, Hiroki Koyama, Nanami Mizusawa, Nobuhiro Kan-No, Engkong Tan, Shuichi Asakawa, Shugo Watabe
Medaka (Oryzias latipes) is a temperate eurythermal fish that is able to survive over a wide range of water temperatures ranging from near zero to over 30°C throughout the year; it maintains its normal physiological and biochemical processes through temperature acclimation. To determine the mechanisms involved in temperature acclimation of fish, the fast skeletal muscle tissues of medaka underwent global gene expression analysis using next-generation sequencing. Ten individuals were placed into two aquariums at 24°C...
August 2, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28798080/long-term-programming-effect-of-early-hypoxia-and-high-carbohydrate-diet-at-first-feeding-on-glucose-metabolism-in-rainbow-trout-juveniles
#6
Jingwei Liu, Karine Dias, Elisabeth Plagnes-Juan, Vincent Véron, Stéphane Panserat, Lucie Marandel
Environmental conditions experienced during early life play an important role in the long-term metabolic status of individuals. The present study investigated whether early hypoxia exposure (24 h, 2.5 mg·l(-1), 20% dissolved O2) during embryo stage alone (hypoxic history) or combined with a 5-day high carbohydrate diet (60%) stimulus at first-feeding (high carbohydrate diet history) can affect the glucose metabolism later in life, i.e. in fish juveniles. After 19 weeks of growth, we observed a decrease in final body weight in fish with a high carbohydrate diet history...
August 10, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28797654/do-differences-in-the-activities-of-carbohydrate-metabolism-enzymes-between-lake-whitefish-ecotypes-match-predictions-from-transcriptomic-studies
#7
Anne C Dalziel, Martin Laporte, Helga Guderley, Louis Bernatchez
Transcriptomic studies are facilitating the search for the molecular bases of adaptation in natural populations, but the impact of these differences in mRNA content on animal physiology are often unknown. One way to determine if molecular changes have the potential to influence animal physiology and performance is to test for correlated changes at higher levels of biological organization, including enzyme activity. Here, we measure the activities of carbohydrate metabolism enzymes to test if previously documented genetic and transcriptomic variation between 'dwarf' and 'normal' Lake Whitefish ecotypes are associated with corresponding changes in enzyme activity (measured as maximal rate, Vmax) in liver and skeletal muscle...
August 7, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28793853/equine-skeletal-muscle-adaptations-to-exercise-and-training-evidence-of-differential-regulation-of-autophagosomal-and-mitochondrial-components
#8
Kenneth Bryan, Beatrice A McGivney, Gabriella Farries, Paul A McGettigan, Charlotte L McGivney, Katie F Gough, David E MacHugh, Lisa M Katz, Emmeline W Hill
BACKGROUND: A single bout of exercise induces changes in gene expression in skeletal muscle. Regular exercise results in an adaptive response involving changes in muscle architecture and biochemistry, and is an effective way to manage and prevent common human diseases such as obesity, cardiovascular disorders and type II diabetes. However, the biomolecular mechanisms underlying such responses still need to be fully elucidated. Here we performed a transcriptome-wide analysis of skeletal muscle tissue in a large cohort of untrained Thoroughbred horses (n = 51) before and after a bout of high-intensity exercise and again after an extended period of training...
August 9, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28783713/aging-and-sarcopenia-associate-with-specific-interactions-between-gut-microbes-serum-biomarkers-and-host-physiology-in-rats
#9
Jay Siddharth, Anirikh Chakrabarti, Alice Pannérec, Sonia Karaz, Delphine Morin-Rivron, Mojgan Masoodi, Jerome N Feige, Scott James Parkinson
The microbiome has been demonstrated to play an integral role in the maintenance of many aspects of health that are also associated with aging. In order to identify areas of potential exploration and intervention, we simultaneously characterized age-related alterations in gut microbiome, muscle physiology and serum proteomic and lipidomic profiles in aged rats to define an integrated signature of the aging phenotype. We demonstrate that aging skews the composition of the gut microbiome, in particular by altering the Sutterella to Barneseilla ratio, and alters the metabolic potential of intestinal bacteria...
July 17, 2017: Aging
https://www.readbyqxmd.com/read/28780899/mapping-the-human-skeletal-muscle-proteome-progress-and-potential
#10
Daniele Capitanio, Manuela Moriggi, Cecilia Gelfi
Abtract Introduction: Human skeletal muscle represents 40% of our body mass and deciphering its proteome composition to further understand mechanisms regulating muscle function under physiological and pathological conditions has proved a challenge. The inter-individual variability, the presence of structurally and functionally different muscle types and the high protein dynamic range require carefully selected methodologies for the assessment of the muscle proteome. Furthermore, physiological studies are understandingly hampered by ethical issues related to biopsies on healthy subjects, making it difficult to recruit matched controls essential for comparative studies...
August 7, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28777921/minimal-alteration-in-muscle-lipid-genes-following-stabilized-weight-loss
#11
Robert H Coker, Leizleigh Robinette, Philip A Kern
PURPOSE: Variations in skeletal muscle peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1∝), carntine palmitoyltransferase (CPT-1), perilipin protein (PLIN2), and adipose tissue triglyceride lipase (ATGL), and comparative gene identification-58 (CGI-58) have been described to play important roles in the metabolic regulation of lipid oxidation, and may influence intramyocellular lipid (IMCL) and muscle lipid droplet size (LDS). While acute changes in caloric balance and/or aerobic capacity may affect lipid metabolism, the influence of sustained weight loss derived from caloric restriction (CWL) compared to exercise training (EWL) on the above mentioned parameters has not been fully elucidated...
August 4, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28771592/deep-rna-sequencing-of-pectoralis-muscle-transcriptomes-during-late-term-embryonic-to-neonatal-development-in-indigenous-chinese-duck-breeds
#12
Chunhong Zhu, Weitao Song, Zhiyun Tao, Hongxiang Liu, Wenjuan Xu, Shuangjie Zhang, Huifang Li
Pectoral muscle (PM) comprises an important component of overall meat mass in ducks. However, PM has shown arrested or even reduced growth during late embryonic development, and the molecular mechanisms underlying PM growth during the late embryonic to neonatal period in ducks have not been addressed. In this study, we characterized potential candidate genes and signaling pathways related to PM development using RNA sequencing of PM samples selected at embryonic days (E) 21 and 27 and 5 days post-hatch (dph) in two duck breeds (Gaoyou and Jinding ducks)...
2017: PloS One
https://www.readbyqxmd.com/read/28768181/long-term-cold-adaptation-does-not-require-fgf21-or-ucp1
#13
Susanne Keipert, Maria Kutschke, Mario Ost, Thomas Schwarzmayr, Evert M van Schothorst, Daniel Lamp, Laura Brachthäuser, Isabel Hamp, Sithandiwe E Mazibuko, Sonja Hartwig, Stefan Lehr, Elisabeth Graf, Oliver Plettenburg, Frauke Neff, Matthias H Tschöp, Martin Jastroch
Brown adipose tissue (BAT)-dependent thermogenesis and its suggested augmenting hormone, FGF21, are potential therapeutic targets in current obesity and diabetes research. Here, we studied the role of UCP1 and FGF21 for metabolic homeostasis in the cold and dissected underlying molecular mechanisms using UCP1-FGF21 double-knockout mice. We report that neither UCP1 nor FGF21, nor even compensatory increases of FGF21 serum levels in UCP1 knockout mice, are required for defense of body temperature or for maintenance of energy metabolism and body weight...
August 1, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28766947/creatine-monohydrate-enhances-energy-status-and-reduces-glycolysis-via-inhibition-of-ampk-pathway-in-pectoralis-major-muscle-of-transport-stressed-broilers
#14
Lin Zhang, Xiaofei Wang, Jiaolong Li, Xudong Zhu, Feng Gao, Guanghong Zhou
Creatine monohydrate (CMH) contributes to reduce transport-induced muscle rapid glycolysis and improve meat quality of broilers, but the underlying mechanism is still unknown. Therefore, this study aimed to investigate the molecular mechanisms underlying the ameliorative effects of CMH on muscle glycolysis metabolism of transported broilers during summer. The results showed that 3 h transport during summer elevated chicken live weight loss and plasma corticosterone concentration; decreased muscle concentrations of ATP, creatine, and energy charge value; increased muscle AMP concentration and AMP/ATP ratio; and upregulated muscle mRNA expression of LKB1 and AMPKα2, as well as protein expression of p-LKB1(Thr189) and p-AMPKα(Thr172), which subsequently resulted in rapid glycolysis in the pectoralis major muscle and consequent reduction of meat quality...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28763040/strategies-towards-improved-feed-efficiency-in-pigs-comprise-molecular-shifts-in-hepatic-lipid-and-carbohydrate-metabolism
#15
Henry Reyer, Michael Oster, Elizabeth Magowan, Dirk Dannenberger, Siriluck Ponsuksili, Klaus Wimmers
Due to the central role of liver tissue in partitioning and metabolizing of nutrients, molecular liver-specific alterations are of considerable interest to characterize an efficient conversion and usage of feed in livestock. To deduce tissue-specific and systemic effects on nutrient metabolism and feed efficiency (FE) twenty-four animals with extreme phenotypes regarding residual feed intake (RFI) were analyzed. Transcriptome and fatty acid profiles of liver tissue were complemented with measurements on blood parameters and thyroid hormone levels...
August 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28751307/esglut4-and-chhbp-are-involved-in-the-regulation-of-glucose-homeostasis-in-the-crustacean-eriocheir-sinensis
#16
Ran Li, Jin-Ze Tian, Mo-Ran Wang, Li-Na Zhu, Jin-Sheng Sun
Glucose is an essential energy source for both vertebrates and invertebrates. In mammals, glucose uptake is mediated primarily by glucose transporters (GLUTs), members of the major facilitator superfamily (MFS) of passive transporters. Among the GLUTs, GLUT4 is the main glucose transporter in muscles and adipocytes. In skeletal muscle cells, GLUT4 interacts with the lipid raft protein flotillin to transport glucose upon stimulation by insulin. Although several studies have examined GLUT4 function in mammals, few have been performed in crustaceans, which also use glucose as their main energy source...
July 27, 2017: Biology Open
https://www.readbyqxmd.com/read/28751290/myoadenylate-deaminase-deficiency-a-frequent-cause-of-muscle-pain-a-case-detected-by-exercise-testing
#17
Lydie Lim, Maeva Palayer, Antoine Bruneau, Franck Letournel, Cédric Le Maréchal, Gilles Simard, Pascal Reynier, Chadi Homedan, Aleksandra Nadaj-Pakleza
Myoadenylate deaminase deficit (MAD, MIM#615511) is the most common cause of metabolic myopathies with an estimated prevalence of 1-2% in the general population. We report the case of a 39-year-old man suffering from severe skeletal muscle pain that had developed gradually for 4 years. A moderate increase in creatine kinase (CK) was the only biological sign observed. This study takes a closer look at a common but poorly known pathology and highlights the interest of the dynamic metabolic investigations carried out during exercise stress test with a cycle ergometer...
August 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28747716/burn-induced-muscle-metabolic-derangements-and-mitochondrial-dysfunction-are-associated-with-activation-of-hif-1%C3%AE-and-mtorc1-role-of-protein-farnesylation
#18
Harumasa Nakazawa, Kazuhiro Ikeda, Shohei Shinozaki, Masayuki Kobayashi, Yuichi Ikegami, Ming Fu, Tomoyuki Nakamura, Shingo Yasuhara, Yong-Ming Yu, J A Jeevendra Martyn, Ronald G Tompkins, Kentaro Shimokado, Tomoko Yorozu, Hideki Ito, Satoshi Inoue, Masao Kaneki
Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects of metabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction and hyperlactatemia. Nonetheless, the molecular pathogenesis and the relation between these diverse metabolic alterations are poorly understood. We have previously shown that burn increases farnesyltransferase (FTase) expression and protein farnesylation and that FTase inhibitor (FTI) prevents burn-induced hyperlactatemia, insulin resistance, and increased proteolysis in mouse skeletal muscle...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28744984/redox-homeostasis-and-age-related-deficits-in-neuromuscular-integrity-and-function
#19
REVIEW
Giorgos K Sakellariou, Adam P Lightfoot, Kate E Earl, Martin Stofanko, Brian McDonagh
Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human body. Age-related muscle atrophy (sarcopenia) and weakness, characterized by progressive loss of lean muscle mass and function, is a major contributor to morbidity and has a profound effect on the quality of life of older people. With a continuously growing older population (estimated 2 billion of people aged >60 by 2050), demand for medical and social care due to functional deficits, associated with neuromuscular ageing, will inevitably increase...
July 26, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28743971/muscle-transcriptome-analysis-reveals-molecular-pathways-and-biomarkers-involved-in-extreme-ultimate-ph-and-meat-defect-occurrence-in-chicken
#20
Stéphane Beauclercq, Christelle Hennequet-Antier, Christophe Praud, Estelle Godet, Anne Collin, Sophie Tesseraud, Sonia Métayer-Coustard, Marie Bourin, Marco Moroldo, Frédéric Martins, Sandrine Lagarrigue, Elisabeth Le Bihan-Duval, Cécile Berri
The processing ability and sensory quality of chicken breast meat are highly related to its ultimate pH (pHu), which is mainly determined by the amount of glycogen in the muscle at death. To unravel the molecular mechanisms underlying glycogen and meat pHu variations and to identify predictive biomarkers of these traits, a transcriptome profiling analysis was performed using an Agilent custom chicken 8 × 60 K microarray. The breast muscle gene expression patterns were studied in two chicken lines experimentally selected for high (pHu+) and low (pHu-) pHu values of the breast meat...
July 25, 2017: Scientific Reports
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