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JOURNAL ARTICLE
Sarah McErlean, John Broughan, Geoff McCombe, Ronan Fawsitt, Mark Ledwidge, Walter Cullen, Joe Gallagher
BACKGROUND: Worldwide, atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults and poses a significant burden to patients, physicians, and healthcare systems. We developed a quality of care score based on the Atrial Fibrillation Better Care pathway recommended by the European Society of Cardiology and the European Heart Rhythm Association guidelines. This is a 14-point score that we have termed the MAGIC score(Management of Atrial Fibrillation in Integrated Care and General Practice)...
January 30, 2024: Family Practice
#22
JOURNAL ARTICLE
Wilfried Mullens, Jeroen Dauw, Finn Gustafsson, Alexandre Mebazaa, Jan Steffel, Klaus K Witte, Victoria Delgado, Cecilia Linde, Kevin Vernooy, Stefan D Anker, Ovidiu Chioncel, Davor Milicic, Gerd Hasenfuß, Piotr Ponikowski, Ralph Stephan von Bardeleben, Friedrich Koehler, Frank Ruschitzka, Kevin Damman, Ehud Schwammenthal, Jeffrey M Testani, Faiez Zannad, Michael Böhm, Martin R Cowie, Kenneth Dickstein, Tiny Jaarsma, Gerasimos Filippatos, Maurizio Volterrani, Thomas Thum, Stamatis Adamopoulos, Alain Cohen-Solal, Brenda Moura, Amina Rakisheva, Arsen Ristic, Antoni Bayes-Genis, Sophie Van Linthout, Carlo Gabriele Tocchetti, Gianluigi Savarese, Hadi Skouri, Marianna Adamo, Offer Amir, Mehmet Birhan Yilmaz, Maggie Simpson, Mariya Tokmakova, Arantxa González, Massimo Piepoli, Petar Seferovic, Marco Metra, Andrew J S Coats, Giuseppe M C Rosano
Implantable devices form an integral part of the management of patients with heart failure (HF) and provide adjunctive therapies in addition to cornerstone drug treatment. Although the number of these devices is growing, only few are supported by robust evidence. Current devices aim to improve haemodynamics, improve reverse remodelling, or provide electrical therapy. A number of these devices have guideline recommendations and some have been shown to improve outcomes such as cardiac resynchronization therapy, implantable cardioverter-defibrillators and long-term mechanical support...
January 25, 2024: European Journal of Heart Failure
#23
JOURNAL ARTICLE
Winnie Chua, Alya Khashaba, Hansel Canagarajah, Jens Cosedis Nielsen, Luigi di Biase, Karl Georg Haeusler, Gerhard Hindricks, Lluis Mont, Jonathan Piccini, Renate B Schnabel, Ulrich Schotten, Ursula-Henrike Wienhues-Thelen, Tanja Zeller, Larissa Fabritz, Paulus Kirchhof
BACKGROUND: Different disease processes can combine to cause to atrial fibrillation (AF). Their contribution to recurrent AF after ablation in patients is not known. OBJECTIVE: Cardiovascular processes associated with recurrent AF after AF ablation were determined by quantifying biomolecules related to inflammation, metabolism, proliferation, fibrosis, shear-stress, atrial pressure, and others in the AXAFA biomolecule study. METHODS: Twelve circulating cardiovascular biomolecules (ANGPT2, BMP10, CA125, hsCRP, ESM1, FABP3, FGF23, GDF15, IGFBP7, IL6, NT-proBNP, hsTnT) were quantified in plasma samples obtained prior to a first AF ablation using high-throughput, high-precision assays...
January 24, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#24
JOURNAL ARTICLE
Tommaso Bucci, Alena Shantsila, Giulio Francesco Romiti, Wee-Siong Teo, Tze-Fan Chao, Wataru Shimizu, Giuseppe Boriani, Hung-Fat Tse, Rungroj Krittayaphong, Gregory Y H Lip
BACKGROUND: The COOL-AF (Cohort of Antithrombotic Use and Optimal International Normalized Ratio Levels in Patients with Atrial Fibrillation) risk scores for death, bleeding, and thromboembolic events (TEs) were derived from the COOL-AF cohort from Thailand and require external validation. OBJECTIVES: The authors sought to externally validate the COOL-AF scores in the APHRS (Asia-Pacific Heart Rhythm Society) registry and to compare their performance in the ESC-EHRA (European Society of Cardiology-European Heart Rhythm Association) EORP-AF (EURObservational Research Programme in Atrial Fibrillation) General Long-Term Registry...
January 2024: JACC Asia
#25
JOURNAL ARTICLE
Christina Menexi, Mohamed ElRefai, Mohamed Abouelasaad, Anne Y T Chua, Ishita Handa, Clare Newbery, Nicola Hoskins, Waqas Ullah, Arthur Yue, Paul R Roberts, John Paisey
BACKGROUND: Peri-procedural complications associated with cardiac implantable electronic devices are not uncommon. European Society of Cardiology guidelines recommend device checks of all devices within 72 h of implant. European Heart Rhythm Association expert practical guide on Cardiac implantable electronic devices (CIEDs) recommend that a chest x-ray (CXR) should be performed within 24 h to rule out pneumothorax and document lead positions. First, the rate of peri-procedural complications associated with CIED implants at our center, as well as patient and/or procedural-related factors that are associated with higher rates of complications, is analyzed...
February 2024: Pacing and Clinical Electrophysiology: PACE
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JOURNAL ARTICLE
Bernadette Corica, Giulio Francesco Romiti, Amalie Helme Simoni, Davide Antonio Mei, Tommaso Bucci, John L P Thompson, Min Qian, Shunichi Homma, Marco Proietti, Gregory Y H Lip
AIMS: The influence of social determinants of health (SDOH) on the prognosis of Heart Failure and reduced Ejection Fraction (HFrEF) is increasingly reported. We aim to evaluate the contribution of educational status on outcomes in patients with HFrEF. METHODS: We used data from the WARCEF trial, which randomized HFrEF patients with sinus rhythm to receive Warfarin or Aspirin; educational status of patients enrolled was collected at baseline. We defined three levels of education: low, medium and high level, according to the highest qualification achieved or highest school grade attended...
January 11, 2024: European Journal of Clinical Investigation
#27
REVIEW
Rosa Talerico, Roberto Pola, Frederikus Albertus Klok, Menno Volkert Huisman
Patients at extremes of body weight are underrepresented in randomized controlled trials of direct-acting oral anticoagulants (DOACs). Therefore, their optimal anticoagulant treatment remains a topic of debate. The aim of this narrative review is to summarize the evidence on the pharmacokinetic and pharmacodynamic profile of DOACs for treating patients at extremes of body weight in venous thromboembolism (VTE) and in the prevention of cardioembolic stroke in nonvalvular atrial fibrillation (NVAF). A literature search was conducted in the main bibliographic databases, and the most relevant reviews and original articles on the topic were selected...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
#28
JOURNAL ARTICLE
Steven van Zanten, Jelle S Y de Jong, Mike G Scheffer, Evert C A Kaal, Joris R de Groot, Frederik J de Lange
AIMS: We aimed to identify all syncope units (SUs) in the Netherlands and assess the extent to which these SUs fulfil the essential requirements outlined by the consensus statements of the European Heart Rhythm Association and the European Society of Cardiology syncope guidelines. For this, we developed the SU-19 score, a novel guideline based validation tool for best practice. METHODS: All outpatient clinics of cardiology, neurology and internal medicine in the Netherlands were screened for presence of any form of structured specialised syncope care...
January 8, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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JOURNAL ARTICLE
Tharusan Thevathasan, Lisa Füreder, Marie Fechtner, Sivagowry Rasalingam Mørk, Benedikt Schrage, Dirk Westermann, Louise Linde, Emilie Gregers, Jo Bønding Andreasen, Christopher Gaisendrees, Takashi Unoki, Andrea L Axtell, Koji Takeda, Alice V Vinogradsky, Pedro Gonçalves-Teixeira, Anthony Lemaire, Marta Alonso-Fernandez-Gatta, Hoong Sern Lim, Arthur Reshad Garan, Amarinder Bindra, Gary Schwartz, Ulf Landmesser, Carsten Skurk
OBJECTIVES: Extracorporeal cardiopulmonary resuscitation (ECPR) is the implementation of venoarterial extracorporeal membrane oxygenation (VA-ECMO) during refractory cardiac arrest. The role of left-ventricular (LV) unloading with Impella in addition to VA-ECMO ("ECMELLA") remains unclear during ECPR. This is the first systematic review and meta-analysis to characterize patients with ECPR receiving LV unloading and to compare in-hospital mortality between ECMELLA and VA-ECMO during ECPR...
January 5, 2024: Critical Care Medicine
#30
JOURNAL ARTICLE
Andreas Metzner, Arian Sultan, Piotr Futyma, Sergio Richter, Laura Perrotta, K R Julian Chun
AIMS: Pericardial tamponade (PT) is the most frequent severe complication during electrophysiology (EP) procedures and requires immediate, co-ordinated, and effective treatment. However, multiple aspects of PT treatment are either not standardized or are under ongoing debate. METHODS AND RESULTS: An online questionnaire consisting of 26 multiple-choice questions was sent out to the European Heart Rhythm (EHRA) Research Network and also distributed via social media outputs...
December 28, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#31
JOURNAL ARTICLE
Zhonglei Xie, Baozhen Qi, Zimu Wang, Fuhai Li, Chaofeng Chen, Chaofu Li, Shuai Yuan, Shun Yao, Jingmin Zhou, Junbo Ge
BACKGROUND AND AIMS: Patients with heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) have worse clinical outcomes than those with sinus rhythm (SR). We aim to investigate whether maintaining SR in patients with HFpEF through a strategy such as AF ablation would improve outcomes. METHODS: This is a cohort study that analyzed 1034 patients (median age 69 [63-76] years, 46.2% [478/1034] female) with HFpEF and AF. Of these, 392 patients who underwent first-time AF ablation were assigned to the ablation group, and the remaining 642 patients, who received only medical therapy, were assigned to the no ablation group...
December 14, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#32
JOURNAL ARTICLE
Sayedeh Hussaini, Rupamanjari Majumder, Valentin Krinski, Stefan Luther
Life-threatening cardiac arrhythmias such as ventricular tachycardia and fibrillation are common precursors to sudden cardiac death. They are associated with the occurrence of abnormal electrical spiral waves in the heart that rotate at a high frequency. In severe cases, arrhythmias are combated with a clinical method called defibrillation, which involves administering a single global high-voltage shock to the heart to reset all its activity and restore sinus rhythm. Despite its high efficiency in controlling arrhythmias, defibrillation is associated with several negative side effects that render the method suboptimal...
December 2023: Pflügers Archiv: European Journal of Physiology
#33
JOURNAL ARTICLE
Giacomo Mugnai, Michal Farkowski, Luca Tomasi, Laurent Roten, Federico Migliore, Carlo de Asmundis, Giulio Conte, Serge Boveda, Julian K R Chun
INTRODUCTION: Limited data are available regarding venous thromboembolism (VTE), specifically deep vein thrombosis (DVT) and pulmonary embolism (PE), following right-sided ablations and electrophysiological (EP) studies. Compared to left-sided procedures, no guidelines on antithrombotic management strategies for the prevention of DVT and PE are available. The main purpose of the present European Heart Rhythm Association (EHRA) survey is to report the current management of right-sided EP procedures, focusing on anticoagulation and prevention of VTE...
December 13, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#34
JOURNAL ARTICLE
Tiberiu A Pana, Mamas A Mamas, Nicholas J Wareham, Kay-Tee Khaw, Dana K Dawson, Phyo K Myint
AIMS: Better understanding of sex differences in cardiovascular disease (CVD) is essential in tailoring appropriate preventative strategies. Using a large population-based study with follow-up >25 years, we aimed to determine sex-specific lifetime risks of incident CVD and cardiovascular (CV) mortality amongst populations with and without prevalent CVD. METHODS AND RESULTS: Participants were drawn from the European Prospective Investigation into Cancer-Norfolk and followed up for a median of 26...
November 30, 2023: European Journal of Preventive Cardiology
#35
JOURNAL ARTICLE
Comparison of strategies for catheter ablation of left posterior fascicular ventricular tachycardia.
Hui-Qiang Wei, Wanwen Chen, Sini Luo, Zili Liao, Xianhong Fang, Hongtao Liao, Qi Sun, Xiao-Gang Guo, Jian-Du Yang, Jackson J Liang, Shulin Wu, Yumei Xue, Jian Ma, Xianzhang Zhan
AIMS: Traditional ablation strategies including targeting the earliest Purkinje potential (PP) during left posterior fascicular (LPF) ventricular tachycardia (VT) or linear ablation at the middle segment of LPF during sinus rhythm are commonly used for the treatment of LPF-VT. Catheter ablation for LPF-VT targeting fragmented antegrade Purkinje (FAP) potential during sinus rhythm is a novel approach. We aimed to compare safety and efficacy of different ablation strategies (FAP ablation vs...
November 2, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#36
JOURNAL ARTICLE
Susanne Löbe, Pierre Stellmach, Angeliki Darma, Sebastian Hilbert, Ingo Paetsch, Cosima Jahnke, Andreas Bollmann, Gerhard Hindricks, Simon Kircher
AIMS: Low-voltage areas (LVAs) found during left atrial (LA) electroanatomical mapping are increasingly targeted by radiofrequency catheter ablation (RFCA) on top of pulmonary vein isolation to improve arrhythmia-free survival in patients with atrial fibrillation (AF). However, pre-procedural prediction of LVAs remains challenging. The purpose of the present study was to describe the association between parameters of LA function and dimensions, respectively, derived from pre-procedural cardiovascular magnetic resonance (CMR) imaging, and the presence of LVAs on LA voltage mapping...
November 2, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#37
JOURNAL ARTICLE
Shujuan Zhao, Hengfen Dai, Jiaxin Chen, Ming Ni, Wenxing Peng, Xiaoyu Li, Fen Li, Boya Chen, Haixia Cai, Yinping Liu, Zhichun Gu, Song Du, Peizhi Ma
AIM: As the direct oral anticoagulant (DOAC) most recently approved in China, data pertaining to clinical edoxaban use are still scarce. This study investigated the prevalence of and contemporary trends in edoxaban prescription among Chinese patients as well as factors associated with its inappropriate use in a multi-center registry of patients treated in real-world clinical practice. METHODS: This real-world, prospective, multicenter, and non-interventional study included 1005 inpatients treated with edoxaban...
November 10, 2023: British Journal of Clinical Pharmacology
#38
JOURNAL ARTICLE
Beatrice Zanchi, Francesca Faraci, Ali Gharaviri, Marco Bergonti, Tomas Monga, Angelo Auricchio, Giulio Conte
BACKGROUND AND AIMS: Brugada syndrome (BrS) is an inherited disease associated with an increased risk of ventricular arrhythmias. Recent studies have reported the presence of an altered atrial phenotype characterized by abnormal P-wave parameters. The aim of this study was to identify BrS based exclusively on P waves features through an artificial intelligence (AI)-based model. METHODS: Continuous 5-minute 12-lead ECG recordings were obtained in sinus rhythm from a) patients with spontaneous or ajmaline-induced BrS and no history of AF and b) subjects with suspected BrS and negative ajmaline challenge...
November 7, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#39
JOURNAL ARTICLE
Helena Stengl, Ramanan Ganeshan, Regina von Rennenberg, Simon Hellwig, Juliane Herm, Thomas Krause, Axel Bauer, Matthias Endres, Karl Georg Haeusler, Jan F Scheitz, Christian H Nolte
BACKGROUND: Heart rate turbulence (HRT), an ECG-based marker of autonomic cardiac regulation, has shown high prognostic value in patients with established cardiovascular diseases, while data in patients with acute ischemic stroke are scarce. PATIENTS AND METHODS: The HRT parameters turbulence onset and turbulence slope were analyzed using Holter-ECG recordings from patients with acute ischemic stroke, consecutively enrolled in the prospective observational HEBRAS study...
November 6, 2023: European Stroke Journal
#40
JOURNAL ARTICLE
Ziliang Ye, Mathijs S van Schie, Lisa Pool, Annejet Heida, Paul Knops, Yannick J H J Taverne, Bianca J J M Brundel, Natasja M S de Groot
AIMS: Areas of conduction inhomogeneity (CI) during sinus rhythm (SR) may facilitate initiation and perpetuation of atrial fibrillation (AF). Currently, no tool is available to quantify the severity of conduction inhomogeneity. Our purpose is to develop and validate a novel tool using unipolar electrograms (EGMs) only to quantify the severity of conduction inhomogeneity in the atria. METHODS AND RESULTS: Epicardial mapping of the right (RA) and left atrium, including Bachmann's bundle was performed in 235 patients undergoing coronary artery bypass grafting surgery...
November 1, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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