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https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#1
REVIEW
José Moreira, Clarisse S Bressan, Patricia Brasil, Andre M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America (LA) are diverse and its complexity increase as the proportion of fever due to malaria decreases as control and new pathogens emerge in the region. In this context, it is important to shed light over the gaps on the epidemiological characteristics and the geographic range for many AFI aetiologies. AIMS: To review studies on community-acquired fever etiology other than malaria in LA, and to highlight knowledge gaps and challenges needing further investigation...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777650/modeling-dengue-vector-population-using-remotely-sensed-data-and-machine-learning
#2
Juan M Scavuzzo, Francisco Trucco, Manuel Espinosa, Carolina B Tauro, Marcelo Abril, Carlos M Scavuzzo, Alejandro C Frery
Mosquitoes are vectors of many human diseases. In particular, Aedes ægypti (Linnaeus) is the main vector for Chikungunya, Dengue, and Zika viruses in Latin America and it represents a global threat. Public health policies that aim at combating this vector require dependable and timely information, which is usually expensive to obtain with field campaigns. For this reason, several efforts have been done to use remote sensing due to its reduced cost. The present work includes the temporal modeling of the oviposition activity (measured weekly on 50 ovitraps in a north Argentinean city) of Aedes ægypti (Linnaeus), based on time series of data extracted from operational earth observation satellite images...
May 16, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29776426/detection-of-zika-virus-infection-among-asymptomatic-pregnant-women-in-the-north-of-peru
#3
Claudia Weilg, Lucinda Troyes, Zoila Villegas, Wilmer Silva-Caso, Fernando Mazulis, Ammy Febres, Mario Troyes, Miguel Angel Aguilar-Luis, Juana Del Valle-Mendoza
OBJECTIVE: To report an outbreak of ZIKV infection among asymptomatic pregnant women during 2016 in the city of Jaen, Cajamarca. RESULTS: Zika virus RNA was detected in 3.2% (n = 36) of cases by RT-PCR. The mean age of patients positive for ZIKV infection was 29.6 years. 7 patients (19.4%) infected with ZIKV were in their first-trimester of gestation, 13 (36.1%) were in their second-trimester, and 16 (44%) were in their third-trimester. All of the infected pregnant women were asymptomatic...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29774519/zika-virus-baculovirus-expressed-virus-like-particles-induce-neutralizing-antibodies-in-mice
#4
Shiyu Dai, Tao Zhang, Yanfang Zhang, Hualin Wang, Fei Deng
The newly emerged mosquito-borne Zika virus (ZIKV) strains pose a global challenge owing to its ability to cause microcephaly and neurological disorders. Several ZIKV vaccine candidates have been proposed, including inactivated and live attenuated virus vaccines, vector-based vaccines, DNA and RNA vaccines. These have been shown to be efficacious in preclinical studies in mice and nonhuman primates, but their use will potentially be a threat to immunocompromised individuals and pregnant women. Virus-like particles (VLPs) are empty particles composed merely of viral proteins, which can serve as a safe and valuable tool for clinical prevention and treatment strategies...
May 17, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29774286/biological-control-of-anopheles-darlingi-aedes-aegypti-and-culex-quinquefasciatus-larvae-using-shrimps
#5
Willian Marinho Dourado Coelho, Juliana de Carvalho Apolinário Coêlho, Katia Denise Saraiva Bresciani, Wilma Aparecida Starke Buzetti
Mosquitoes can act as vectors of important diseases such as malaria, dengue, Zika virus, yellow fever, Chikungunya and Mayaro fever, in addition to filariasis. The use of insecticides, larvicides, bed nets and repellents, besides the use of drugs as chemoprevention and the treatment of the sick are currently the pillars of the control of these vectors. We studied the biological control against of Anopheles darlingi , Aedes aegypti and Culex quinquefasciatus larvae using shrimps of the species M. pantanalense , M...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774022/acute-zika-virus-infection-in-an-endemic-area-shows-modest-proinflammatory-systemic-immunoactivation-and-cytokine-symptom-associations
#6
Jéssica Barletto de Sousa Barros, Paulo Alex Neves da Silva, Rosemary de Carvalho Rocha Koga, Patrícia Gonzalez-Dias, José Rodrigues Carmo Filho, Patrícia Resende Alo Nagib, Verônica Coelho, Helder I Nakaya, Simone Gonçalves Fonseca, Irmtraut Araci Hoffmann Pfrimer
An early immune response to Zika virus (ZIKV) infection may determine its clinical manifestation and outcome, including neurological effects. However, low-grade and transient viremia limits the prompt diagnosis of acute ZIKV infection. We have investigated the plasma cytokine, chemokine, and growth factor profiles of 36 individuals from an endemic area displaying different symptoms such as exanthema, headache, myalgia, arthralgia, fever, hyperemia, swelling, itching, and nausea during early-phase infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29773774/us-and-cuban-scientists-forge-collaboration-on-arbovirus-research
#7
Jorge Pérez-Ávila, Maria G Guzmán-Tirado, Jorge Fraga-Nodarse, Gray Handley, James Meegan, Jose L Pelegrino-Martínez de la Cotera, Anthony S Fauci
After December 17, 2014, when the US and Cuban governments announced their intent to restore relations, the two countries participated in various exchange activities in an effort to encourage cooperation in public health, health research and biomedical sciences. The conference entitled Exploring Opportunities for Arbovirus Research Collaboration, hosted at Havana's Hotel Nacional, was part of these efforts and was the first major US-Cuban scientific conference in over 50 years. Its purpose was to share information about current arbovirus research and recent findings, and to explore opportunities for future joint research...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29773562/neuroimaging-findings-of-zika-virus-associated-neurologic-complications-in-adults
#8
REVIEW
L C Hygino da Cruz, O J M Nascimento, F P P L Lopes, I R F da Silva
When the first suspected cases of neurologic disorders associated with the Zika virus were noticed in Brazil in late 2015, several studies had been conducted to understand the pathophysiology of the disease and its associated complications. In addition to its well-established association with microcephaly in neonates, the Zika virus infection has also been suggested to trigger other severe neurologic complications in adults, such as Guillain-Barré syndrome, radiculomyelitis, and meningoencephalitis. Hence, the Zika virus should be deemed a global threat that can cause devastating neurologic complications among individuals in all age ranges...
May 17, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29772278/zika-virus-incidence-preventive-and-reproductive-behaviors-correlates-from-new-survey-data
#9
Climent Quintana-Domeque, José Raimundo Carvalho, Victor Hugo de Oliveira
During the outbreak of the Zika virus, Brazilian health authorities recommended that pregnant women take meticulous precaution to avoid mosquito bites and that women in general use contraceptive methods to postpone/delay pregnancies. In this article, we present new estimates on the Zika virus incidence, its correlates and preventive behaviors in the Northeast of Brazil, where the outbreak initiated, using survey data collected between March 30th and June 3rd of 2016. The target population were women aged 15-49 in the capital cities of the nine states of the Northeast region of Brazil...
May 1, 2018: Economics and Human Biology
https://www.readbyqxmd.com/read/29771784/zika-virus-exposure-in-an-hiv-infected-cohort-in-ghana
#10
K E Sherman, S D Rouster, L X Kong, T M Shata, T Archampong, A Kwara, M T Aliota, J T Blackard
OBJECTIVE: To determine the prevalence and epidemiologic associations of Zika Virus (ZIKV) in HIV-infected patients in Ghana, West Africa. METHODS: We examined the seroprevalence of ZIKV in HIV/HBV co-infected persons in Ghana from sera samples collected from 2012 to 2014 using ELISA assays and plaque reduction neutralization tests (PRNT). RESULTS: Overall, ZIKV antibody was detected in 12.9% of 236 tested samples, though the true estimate of exposure is probably less due cross-reactions with other related viruses...
April 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771234/an-observational-clinical-case-of-zika-virus-associated-neurological-disease-is-associated-with-primary-igg-response-and-enhanced-tnf-levels
#11
Edson Delatorre, Milene Miranda, Diogo A Tschoeke, Patrícia Carvalho de Sequeira, Simone Alves Sampaio, Giselle Barbosa-Lima, Yasmine Rangel Vieira, Luciana Leomil, Fernando A Bozza, José Cerbino-Neto, Patricia T Bozza, Rita Maria Ribeiro Nogueira, Patrícia Brasil, Fabiano L Thompson, Ana M B de Filippis, Thiago Moreno L Souza
Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine)...
May 17, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29770095/zika-virus-where-to-from-here
#12
EDITORIAL
P K Muchaal
After the waves of reported cases of infection with Zika virus swept across the Americas in 2015-16, the overall transmission of the virus in the Western Hemisphere declined in 2017. Between June 8 and August 31, 2017, only 16 new cases of Zika virus infection, all travel-related, were reported in Canada. This represents an 88% reduction in the cases recorded during the same time frame in 2016. Herd immunity undoubtedly constrains the transmission of the virus in endemic regions. However, while most countries in the Americas are no longer observing continuous transmission in the form of sustained increases over time, some areas are experiencing a notable resurgence...
January 4, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770094/travel-related-zika-virus-cases-in-canada-october-2015-june-2017
#13
J Tataryn, L Vrbova, M Drebot, H Wood, E Payne, S Connors, J Geduld, M German, K Khan, P A Buck
Background: Zika virus (ZIKV) is an emerging mosquito-borne disease that can cause severe birth defects if contracted congenitally. Since late 2015, there has been a large increase in the number of travel-related cases of Zika virus infection in Canada. Objective: The objective of this study was to describe the epidemiology of travel-related Zika cases in Canada from October 2015 to June 2017 and review them in the context of the international outbreak in the Americas...
January 4, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770047/emerging-infectious-diseases-prediction-and-detection
#14
N H Ogden, P AbdelMalik, Jrc Pulliam
Emerging infectious diseases (EIDs), including West Nile virus, severe acute respiratory syndrome (SARS) and Lyme disease, have had a direct effect within Canada, while many more EIDs such as Zika, chikungunya and Ebola are a threat to Canadians while travelling. Over 75% of EIDs affecting humans are, or were originally, zoonoses (infectious diseases transmitted from animals to humans). There are two main ways by which infectious diseases can emerge: by changes in their geographical ranges and by adaptive emergence, a genetic change in a microorganism that results in it becoming capable of invading a new niche, often by jumping to a new host species such as humans...
October 5, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769105/ornamental-bromeliads-of-miami-dade-county-florida-are-important-breeding-sites-for-aedes-aegypti-diptera-culicidae
#15
André B B Wilke, Chalmers Vasquez, Paul J Mauriello, John C Beier
BACKGROUND: A major public health concern is the emergence and geographical spread of vector-borne diseases such as Zika and yellow fever. Ornamental bromeliads retaining water in their leaf axils represent potential breeding sites for mosquitoes. As the role of ornamental bromeliads in breeding Aedes aegypti in Miami-Dade County, Florida is unknown, we hypothesize that ornamental bromeliads are important breeding sites for Ae. aegypti. Our objective was to survey bromeliads in areas with high densities of adult Ae...
May 17, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29768624/analysis-of-the-immunological-biomarker-profile-during-acute-zika-virus-infection-reveals-the-overexpression-of-cxcl10-a-chemokine-linked-to-neuronal-damage
#16
Felipe Gomes Naveca, Gemilson Soares Pontes, Aileen Yu-Hen Chang, George Allan Villarouco da Silva, Valdinete Alves do Nascimento, Dana Cristina da Silva Monteiro, Marineide Souza da Silva, Lígia Fernandes Abdalla, João Hugo Abdalla Santos, Tatiana Amaral Pires de Almeida, Matilde Del Carmen Contreras Mejía, Tirza Gabrielle Ramos de Mesquita, Helia Valeria de Souza Encarnação, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Ana Carolina Campi-Azevedo, Jordana Graziela Coelho-Dos-Reis, Lis Ribeiro do Vale Antonelli, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Rajendranath Ramasawmy
BACKGROUND: Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES: To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS: We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29768589/women-s-lives-in-times-of-zika-mosquito-controlled-lives
#17
Ana Rosa Linde, Carlos Eduardo Siqueira
Zika virus infection during pregnancy is a cause of congenital brain abnormalities. Its consequences to pregnancies has made governments, national and international agencies issue advices and recommendations to women. There is a clear need to investigate how the Zika outbreak affects the decisions that women take concerning their lives and the life of their families, as well as how women are psychologically and emotionally dealing with the outbreak. We conducted a qualitative study to address the impact of the Zika epidemic on the family life of women living in Brazil, Puerto Rico, and the US, who were affected by it to shed light on the social repercussions of Zika...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29768530/ns1-codon-usage-adaptation-to-humans-in-pandemic-zika-virus
#18
Caio César de Melo Freire, Giuseppe Palmisano, Carla T Braconi, Fernanda R Cugola, Fabiele B Russo, Patricia Cb Beltrão-Braga, Atila Iamarino, Daniel Ferreira de Lima Neto, Amadou Alpha Sall, Livia Rosa-Fernandes, Martin R Larsen, Paolo Marinho de Andrade Zanotto
BACKGROUND: Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks with millions of human infections. The recent human infections of ZIKV were also associated with severe complications, such as an increase in cases of Guillain-Barre syndrome and the emergence of congenital Zika syndrome...
May 10, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29768102/identification-of-dengue-and-chikungunya-cases-among-suspected-cases-of-yellow-fever-in-the-democratic-republic-of-the-congo
#19
Sheila Makiala-Mandanda, Steve Ahuka-Mundeke, Jessica L Abbate, Elisabeth Pukuta-Simbu, Justus Nsio-Mbeta, Nicolas Berthet, Eric Maurice Leroy, Pierre Becquart, Jean-Jacques Muyembe-Tamfum
For more than 95% of acute febrile jaundice cases identified through surveillance for yellow fever, a reemerging arthropod-borne viral disease, no etiological exploration is ever done. The aim of this study was to test for other arthropod-borne viruses that can induce the same symptoms in patients enrolled in the yellow fever surveillance in the Democratic Republic of the Congo (DRC). Of 652 patients included in the surveillance of yellow fever in DRC from January 2003 to January 2012, 453 patients that tested negative for yellow fever virus (YFV) immunoglobulin M (IgM) antibodies were selected for the study...
May 16, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29767504/motion-based-immunological-detection-of-zika-virus-using-pt-nanomotors-and-a-cellphone
#20
Mohamed Shehata Draz, Nivethitha Kota Lakshminaraasimulu, Sanchana Krishnakumar, Dheerendranath Battalapalli, Anish Vasan, Manoj Kumar Kanakasabapathy, Aparna Sreeram, Shantanu Kallakuri, Prudhvi Thirumalaraju, Yudong Li, Stephane Hua, Xu G Yu, Daniel R Kuritzkes, Hadi Shafiee
Zika virus (ZIKV) infection is an emerging pandemic threat to humans that can be fatal in newborns. Advances in digital health systems and nanoparticles can facilitate the development of sensitive and portable detection technologies for timely management of emerging viral infections. Here we report a nanomotor-based bead-motion cellphone (NBC) system for the immunological detection of ZIKV. The presence of virus in a testing sample results in the accumulation of platinum (Pt)-nanomotors on the surface of beads, causing their motion in H2 O2 solution...
May 16, 2018: ACS Nano
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