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https://www.readbyqxmd.com/read/29039600/synergism-between-%C3%AE-mangostin-and-trail-induces-apoptosis-in-squamous-cell-carcinoma-of-the-oral-cavity-through-the-mitochondrial-pathway
#1
Masakatsu Fukuda, Hide Sakashita, Hiroyasu Hayashi, Junya Shiono, Genki Miyake, Yusuke Komine, Fuyoko Taira, Hideaki Sakashita
Mangosteen (Garcinia mangostana) is a tree found in South-East Asia and the pericarp of its fruit has been used in folk medicine for the treatment of many human illnesses. Mangosteen fruit rinds contain a high concentration of xanthone, which is a type of polyphenol. One type of xanthone, α-mangostin, has been reported to exert chemopreventive effects against chemically-induced colon cancer through the decrease of c-Myc expression, suppressing tumor growth in a mouse model of mammary cancer. A recent study demonstrated the inhibitive effect of α-mangostin on the growth of prostate cancer...
October 12, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29029988/mandibular-embryonal-rhabdomyosarcoma-with-cartilaginous-metaplasia-report-of-a-case-and-review-of-literature
#2
Scott M Peters, Tim Kunkle, Michael A Perrino, Elizabeth M Philipone, Angela J Yoon
Rhabdomyosarcoma (RMS) is a malignant tumor of skeletal muscle origin and frequently involves the head and neck region. It represents the second most common pediatric soft tissue sarcoma and accounts for 3% of all childhood cancers. Here, we report a case of embryonal RMS presenting as a right-sided facial swelling in a 7-year-old boy. Histologically, the tumor consisted of classic embryonal rhabdosarcomatous areas with metaplastic cartilage, in both initial biopsy and final resection specimens. Cartilaginous metaplasia arising in the background of RMS is a rare finding, thus raising a diagnostic challenge...
September 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29027689/oral-mucosa-model-for-electrochemotherapy-treatment-of-dog-mouth-cancer-ex-vivo-in-silico-and-in-vivo-experiments
#3
Daniela O H Suzuki, José A Berkenbrock, Marisa J S Frederico, Fátima R M B Silva, Marcelo M M Rangel
Electrochemotherapy (EQT) is a local cancer treatment well established to cutaneous and subcutaneous tumors. Electric fields are applied to biological tissue in order to improve membrane permeability for cytotoxic drugs. This phenomenon is called electroporation or electropermeabilization. Studies have reported that tissue conductivity is electric field dependent. Electroporation numerical models of biological tissues are essential in treatment planning. Tumors of the mouth are very common in dogs. Inadequate EQT treatment of oral tumor may be caused by significant anatomic variations between dogs and tumor position...
October 13, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29025723/setting-the-stage-for-2018-how-the-changes-in-the-american-joint-committee-on-cancer-union-for-international-cancer-control-cancer-staging-manual-eighth-edition-impact-radiologists
#4
C M Glastonbury, S K Mukherji, B O'Sullivan, W M Lydiatt
The updated eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus-related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(-) oropharyngeal squamous cell carcinoma...
October 12, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29022097/prevalence-of-fibroblast-growth-factor-receptor-1-fgfr1-amplification-in-squamous-cell-carcinomas-of-the-head-and-neck
#5
Till Sebastian Clauditz, Arne Böttcher, Henning Hanken, Kerstin Borgmann, Guido Sauter, Waldemar Wilczak, Tobias Grob, Adrian Münscher
BACKGROUND: FGFR1 is a receptor tyrosine kinases involved in tumor growth signaling, survival, and differentiation in many solid cancer types. There is growing evidence that FGFR1 amplification might predict therapy response to FGFR1 inhibitors in squamous cell lung cancers. To estimate the potential applicability of anti FGFR1 therapies in squamous cell carcinomas of the head and neck, we studied patterns of FGFR1 amplification using fluorescence in situ hybridization (FISH). MATERIALS AND METHODS: A tissue microarray was constructed from 453 primary treatment-naive squamous cell carcinomas of the head and neck regions with histopathological and clinical follow-up data [including oral cavity (n = 222), oropharynx (n = 126), and larynx (n = 105)]...
October 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28990694/suprafascial-versus-traditional-harvesting-technique-for-free-antero-lateral-thigh-flap-a-case-control-study-to-assess-the-best-functional-and-aesthetic-result-in-extremity-reconstruction
#6
Michele Maruccia, Nefer Fallico, Emanuele Cigna, Pedro Ciudad, Fabio Nicoli, Emilio Trignano, Eleonora Nacchiero, Giuseppe Giudice, Diego Ribuffo, Hung-Chi Chen
Clinical applications of ALT flap have currently extended to extremity (hand and foot) as well as oral cavity reconstruction. In these anatomical areas, the traditional harvesting technique presents a few disadvantages such as bulkiness of the recipient site and potential donor site morbidity including damage to the deep fascia and skin graft adhesions. The purpose of the present study was to compare the functional and aesthetic outcomes of upper and lower extremity reconstruction with either suprafascial or subfascial harvested anterolateral (ALT) flaps...
October 9, 2017: Microsurgery
https://www.readbyqxmd.com/read/28987229/controversies-in-oral-and-maxillofacial-oncology
#7
REVIEW
Jacob G Yetzer
Imaging studies are essential components of tumor diagnosis, staging, assessing tumor response to neoadjuvant and adjuvant therapies, and postoperative surveillance on completion of definitive treatment. Treatment of early stage clinically node negative oral cavity squamous cell carcinoma is controversial. Approximately 3% of all head and neck tumors arise within the parotid gland and most often within the superficial lobe, lateral to the facial nerve; about 80% are benign and most are pleomorphic adenoma. In patients with dry eyes failing multiple other treatment modalities and facing ongoing pain and loss of vision, microvascular transplant of the submandibular gland is a viable option...
November 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28981169/mir-200c-3p-spreads-invasive-capacity-in-human-oral-squamous-cell-carcinoma-microenvironment
#8
Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Mai Hazekawa, Atsushi Yasukochi, Takuya Nishinakagawa, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima
Oral squamous cell carcinoma (OSCC) constitutes over 90% of all cancers in the oral cavity. The prognosis for patients with invasive OSCC is poor; therefore, it is important to understand the molecular mechanisms of invasion and subsequent metastasis not only to prevent cancer progression but also to detect new therapeutic targets against OSCC. Recently, extracellular vesicles-particularly exosomes-have been recognized as intercellular communicators in the tumor microenvironment. As exosomic cargo, deregulated microRNAs (miRNAs) can shape the surrounding microenvironment in a cancer-dependent manner...
October 5, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28977897/endoplasmic-reticulum-aminopeptidase-2-involvement-in-metastasis-of-oral-cavity-squamous-cell-carcinoma-discovered-by-proteome-profiling-of-primary-cancer-cells
#9
I-Chun Kuo, Huang-Kai Kao, Yenlin Huang, Chun-I Wang, Jui-Shan Yi, Ying Liang, Chun-Ta Liao, Tzu-Chen Yen, Chih-Ching Wu, Kai-Ping Chang
Oral cavity squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide and associated with poor prognosis and mortality. Discovery of proteins that can improve OSCC treatment is needed. Using comparative proteome profiling of primary cells derived from OSCC and adjacent noncancerous epithelium, endoplasmic reticulum aminopeptidases 2 (ERAP2) has been identified as an OSCC-associated protein. Compared with the adjacent normal tissues, ERAP2 levels were determined to be significantly elevated in OSCC tissues using quantitative real-time PCR and immunohistochemistry...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975663/architectural-patterns-of-p16-immunohistochemical-expression-associated-with-cancer-immunity-and-prognosis-of-head-and-neck-squamous-cell-carcinoma
#10
Hyang Joo Ryu, Eun Kyung Kim, Su Jin Heo, Byoung Chul Cho, Hye Ryun Kim, Sun Och Yoon
We evaluated the expression patterns of p16, which is used as a surrogate marker of HPV infection in head and neck squamous cell carcinoma (HNSCC), in regard to their biological and prognostic implications. p16 expression patterns and infiltrated immune cells were analyzed through immunohistochemistry of p16, CD3, CD8, PD-1, FOXP3, and CD163 on surgically resected HNSCCs (n = 393). Patterns of p16 immunoexpression were defined as STRONG (strong, diffuse expression in cytoplasm, and nucleus in >70% of tumor cells), MARGINAL (expression restricted to tumor margins), MOSAIC (ragged, discontinued expression), NUCLEAR (expression in nuclei only), and ABSENT (no expression)...
October 4, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28975399/palatal-ancient-schwannoma-optical-immunohistochemical-and-ultrastructural-study-with-literature-review
#11
Beatriz Vera-Sirera, Lorena Fernades-Ciacha, Luis M Floria, Francisco Vera-Sempere
Schwannoma or neurilemmoma is a benign encapsulated slow-growing tumor that originates from a Schwann cell of a nerve, and is rare at intraoral locations. Different histological variants of schwannomas have been described, of these degenerative or ancient schwannoma is probably one of the least common in the oral cavity with only 16 previously reported cases, of which only one has been described in palatal location. Although ancient schwannoma shows particular characteristics, it is difficult to diagnose based on clinical and imaging appearance alone; as a result, morphological examination assisted by ancillary techniques is necessary to establish a definite diagnosis...
October 3, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28975016/granular-cell-tumor-of-cecum-a-common-tumor-in-a-rare-site-with-diagnostic-challenge
#12
Meyyappa Devan Rajagopal, Debasis Gochhait, Dasarathan Shanmugan, Adarsh Wamanrao Barwad
Granular cell tumor (GCT) also known as Abrikossoff's tumor is a benign neoplasm that is usually seen in the fourth to sixth decades of life with slight female preponderance. It is most frequently seen in the oral cavity, skin, and subcutaneous tissue. Gastrointestinal tract involvement is uncommon, in which esophagus is the most commonly affected site. There are case reports of GCT in stomach, appendix, colon and rectum. In this article, we report a case of GCT involving cecum. The cell of origin in GCT is controversial...
July 3, 2017: Rare Tumors
https://www.readbyqxmd.com/read/28969885/tumor-pd-l1-expression-is-associated-with-improved-survival-and-lower-recurrence-risk-in-young-women-with-oral-cavity-squamous-cell-carcinoma
#13
G J Hanna, S-B Woo, Y Y Li, J A Barletta, P S Hammerman, J H Lorch
Young patients with oral cavity squamous cell carcinoma (OCSCC) are often recognized as a distinct epidemiological cohort. In this study, genomic and immune-based metrics were correlated with long-term outcomes for a young patient population treated at a single institution. A fully clinically annotated, retrospective cohort of 81 patients aged ≤45 years with OCSCC is described, and the impact of clinicopathological features on long-term survival outcomes is reported. Genomic and immune parameters were integrated utilizing a whole-exome sequencing and immunohistochemical approach among females in the cohort...
September 29, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28955596/cavernous-lymphangioma-of-the-tongue-in-an-adult-a-case-report
#14
Selin Eren, Ahmet Taylan Cebi, Sabri Cemil Isler, Metin Berk Kasapoglu, Nihan Aksakalli, Cetin Kasapoglu
Lymphangioma is a benign hamartomatous lesion caused by congenital malformation of the lymphatic system. This benign tumor is detected most commonly at birth or in early childhood but rarely in adults. On clinical examination, most lymphangiomas contain clear lymph fluid, but some may present as transparent vesicles containing red blood cells due to hemorrhage. In addition, lymphangioma may occur in association with hemangioma. This tumor occurs most commonly in the head and neck area, but rarely in the oral cavity...
2017: J Istanb Univ Fac Dent
https://www.readbyqxmd.com/read/28951751/adjuvant-high-dose-rate-brachytherapy-in-the-management-of-oral-cavity-cancers-5-years-of-experience-in-iran
#15
Ali Kazemian, Mohammad Babaei, Marzieh Lashkari, Reza Ghalehtaki, Ata Garajei, Maziar Motiee-Langroudi, Ahmadreza Sebzari, Ramin Jaberi, Soraya Gholami, Somayyeh Babaloui, Mahdi Aghili
PURPOSE: Brachytherapy is a cost-effective method for the management of oral cavity cancers in low to middle income countries. We aimed to evaluate the clinical outcomes of high-dose-rate interstitial brachytherapy (HDR-IBT) in patients with oral cavity cancer. MATERIAL AND METHODS: From 2009 to 2013, 78 patients (49 combined external beam radiotherapy [EBRT] plus IBT and 29 IBT monotherapy) with oral cavity cancers had been treated in our center. Slightly more than half the patients were male, and the median age was 54 years...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28948509/beyond-the-percentages-of-pd-l1-positive-tumor-cells-induced-versus-constitutive-pd-l1-expression-in-primary-and-metastatic-head-and-neck-squamous-cell-carcinoma
#16
Theresa Scognamiglio, Yao-Tseng Chen
Anti-PD1 antibody has been approved for metastatic squamous cell carcinoma of the head and neck (SCCHN) and objective response rates of approximately 20% have been reported. Defining PD-L1 expression at ≥ 1% tumor cells as positive, PD-L1-positive tumors showed a higher response rate. However, it is unclear whether 1% is the optimal cutoff, and studies on lung cancer suggested 50% cutoff as a stronger predictive biomarker. 96 primary SCCHN from oropharynx and oral cavity and 34 corresponding metastatic lesions were typed for membranous PD-L1 expression...
September 25, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28947680/increased-frg1-expression-reduces-in-vitro-cell-migration-invasion-and-angiogenesis-ex-vivo-supported-by-reduced-expression-in-tumors
#17
Ankit Tiwari, Niharika Pattanaik, Archita Mohanty Jaiswal, Manjusha Dixit
FSHD region gene 1 is a candidate gene for FSHD. FRG1 regulates various muscle related functions, but studies have proposed its role in development and angiogenesis also, where it is involved with tumor associated molecules. Therefore, we decided to look into its role in tumor progression, tumor angiogenesis, and its impact on cellular properties. Cell proliferation, migration, invasion and in vitro angiogenesis assays were performed to decipher effect of FRG1 on endothelial and epithelial cell functions. Q-RT PCR was done for HEK293T (Human Embyonic Kidney cells) cells with altered FRG1 levels to identify associated molecules...
September 25, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28947422/pd-1-expression-in-head-and-neck-squamous-cell-carcinomas-derives-primarily-from-functionally-anergic-cd4-tils-in-the-presence-of-pd-l1-tams
#18
Austin Mattox, Jina Lee, William H Westra, Robert H Pierce, Ronald Ghossein, William C Faquin, Thomas J Diefenbach, Luc Gt Morris, Derrick T Lin, Lori J Wirth, Armida Lefranc-Torres, Eiichi Ishida, Patrick D Chakravarty, Lauren Johnson, Yang Zeng, Huabiao Chen, Mark C Poznansky, Neil M Iyengar, Sara I Pai
Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cavity tumor. In this study, we examined the basis for the activity of PD-1-based immune checkpoint therapy that is being explored widely in head and neck cancers. Using multispectral imaging, we systematically investigated the OTSCC tumor microenvironment (TME) by evaluating the frequency of PD-1 expression in CD8+, CD4+ and FoxP3+ tumor-infiltrating lymphocytes (TIL). We also defined the cellular sources of PD-L1 to evaluate the utility of PD-1:PD-L1 blocking antibody therapy in this patient population...
September 25, 2017: Cancer Research
https://www.readbyqxmd.com/read/28940575/urban-and-rural-differences-in-outcomes-of-head-and-neck-cancer
#19
Jason D Kim, Aryan Firouzbakht, Jenny Y Ruan, Emily Kornelsen, Ali Moghaddamjou, Khodadad R Javaheri, Robert A Olson, Winson Y Cheung
OBJECTIVES/HYPOTHESIS: To assess for potential urban and rural disparities in head and neck cancer (HNC) outcomes within a single-payer healthcare system. STUDY DESIGN: A large retrospective population-based cohort analysis of consecutive HNC patients treated in British Columbia, Canada between 2001 and 2010 was conducted. METHODS: All patients diagnosed with HNC from 2001 to 2010 and referred to any one of five British Columbia Cancer Agency centers for management were reviewed...
September 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28939062/poor-oral-health-affects-survival-in-head-and-neck-cancer
#20
Douglas R Farquhar, Kimon Divaris, Angela L Mazul, Mark C Weissler, Jose P Zevallos, Andrew F Olshan
INTRODUCTION: Poor oral health has emerged as a risk factor for squamous cell carcinoma of the head and neck (HNSCC) but its impact on survival has not been examined. We sought to estimate the impact of oral health indicators on survival in a population-based HNSCC cohort. MATERIALS AND METHODS: Cases (n=1381) and age-, sex- and race-matched controls (n=1396) were participants in the Carolina Head and Neck Cancer Epidemiologic Study (CHANCE). Vital status was determined via linkage with the National Death Index...
October 2017: Oral Oncology
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