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Oral cavity tumors

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https://www.readbyqxmd.com/read/28819469/aggressive-fibromatosis-of-the-oral-cavity-in-a-5-year-old-boy-a-rare-case-report
#1
Keerthi Krishnankutty Nair, Kanad Chaudhuri, Ashok Lingappa, Ranjani Shetty, Pramod Gujjar Vittobarao
Fibrous tissue proliferations express a wide spectrum of histologic and morphologic variation in both infants and adults. This ranges from hypertrophic scar formation at one end to malignant fibrosarcoma at the other end of the spectrum. Aggressive fibromatosis is an intermediate tumor which is in proximity to fibrosarcomas. These are locally invasive and often recur after excision, but do not metastasize. Histologically, they are characterized by proliferating fibroblasts with little mitotic activity. Aggressive fibromatosis in the head and neck region is not common, and very sporadically occurs in the oral cavity or jaw bones...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28801876/tumor-dna-an-emerging-biomarker-in-head-and-neck-cancer
#2
Joseph A Bellairs, Rifat Hasina, Nishant Agrawal
Head and neck cancer (HNC) includes a diverse range of malignancies arising commonly from mucosal epithelia of the upper aerodigestive tract. Head and neck squamous cell carcinoma (HNSCC), the most common form of HNC, develops in the oral cavity, pharynx, and larynx and is associated with tobacco exposure, alcohol abuse, and infection with oncogenic viruses. Despite global advances in cancer care, HNSCC often presents with advanced disease and is associated with poor 5-year survival of ~50%. Genotyping tumor tissue to guide clinical decision-making is becoming commonplace in modern oncology, but in the management of HNSCC, tissue biopsies with cytopathology or histopathology remain the mainstay for diagnosis...
August 12, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28797467/outcomes-of-oral-cavity-cancer-patients-treated-with-surgery-followed-by-postoperative-intensity-modulated-radiation-therapy
#3
Sean R Quinlan-Davidson, Abdallah S R Mohamed, Jeffrey N Myers, Gary B Gunn, Faye M Johnson, Heath Skinner, Beth M Beadle, Ann M Gillenwater, Jack Phan, Steven J Frank, William N William, Andrew J Wong, Stephen Y Lai, Clifton D Fuller, William H Morrison, David I Rosenthal, Adam S Garden
OBJECTIVES: Although treatment paradigms have not changed significantly, radiotherapy, surgery, and imaging techniques have improved, leading us to investigate oncologic and survival outcomes for oral cavity squamous cell cancer (OCSCC) patients treated with surgery followed by postoperative IMRT. MATERIAL AND METHODS: Records of patients with pathological diagnosis of OCSCC treated between 2000 and 2012 were retrospectively reviewed. Patients' demographic, disease, and treatment criteria were extracted...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797455/prognostic-factors-and-occult-nodal-disease-in-mucoepidermoid-carcinoma-of-the-oral-cavity-and-oropharynx-an-analysis-of-the-national-cancer-database
#4
Mark A Ellis, Evan M Graboyes, Terry A Day, David M Neskey
OBJECTIVES: Mucoepidermoid carcinoma (MEC) is an uncommon malignancy that most commonly occurs in the parotid gland followed by the minor salivary glands of the upper aerodigestive tract, most notably in the oral cavity (OC) and oropharynx (OP). Because of its rarity, few studies have been performed that are specific to MEC within the OC and OP. The objective of this study is to describe the tumor characteristics and prognostic features for MEC of the OC and OP. MATERIALS AND METHODS: The National Cancer Database (NCDB) was used for this study...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797445/characteristics-and-long-term-outcomes-of-head-and-neck-squamous-cell-carcinoma-after-solid-organ-transplantation
#5
Samer Alsidawi, Katharine A Price, Ashish V Chintakuntlawar, Gustavo F Westin, Joaquin J Garcia, Daniel J Ma, Scott H Okuno
INTRODUCTION: Immunosuppression after solid organ transplant prevents graft rejection, but leads to increased incidence of various malignancies including head and neck squamous cell carcinoma (HNSCC). Outcomes of patients with post-transplant HNSCC are unknown. MATERIALS AND METHODS: We retrospectively identified patients who developed HNSCC after solid organ transplant between 1995 and 2010. Adults with pathology-proven HNSCC and adequate follow up were included...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28792475/human-papillomavirus-and-the-stroma-bidirectional-crosstalk-during-the-virus-life-cycle-and-carcinogenesis
#6
REVIEW
Megan E Spurgeon, Paul F Lambert
Human papillomaviruses (HPVs) are double-stranded DNA (dsDNA) tumor viruses that are causally associated with human cancers of the anogenital tract, skin, and oral cavity. Despite the availability of prophylactic vaccines, HPVs remain a major global health issue due to inadequate vaccine availability and vaccination coverage. The HPV life cycle is established and completed in the terminally differentiating stratified epithelia, and decades of research using in vitro organotypic raft cultures and in vivo genetically engineered mouse models have contributed to our understanding of the interactions between HPVs and the epithelium...
August 9, 2017: Viruses
https://www.readbyqxmd.com/read/28781903/diagnostic-workup-and-treatment-of-a-rare-apocrine-hidrocystoma-affecting-the-oral-mucosa-a-clinical-and-histological-case-report
#7
Pier Paolo Poli, Luca Creminelli, Valeria Moramarco, Alessandro Del Gobbo, Franco Ferrante, Carlo Maiorana
Apocrine hidrocystomas are rare benign cystic tumors originating from the secretory portion of apocrine sweat glands. To the best of our knowledge, there is no evidence currently available reporting the presence of apocrine hidrocystomas in the oral cavity. Therefore, this case report aims to describe the clinical and histological features of an apocrine hidrocystoma affecting the oral mucosa. A 69-year-old male patient presented with a 1-year history of a solitary, well-circumscribed, submucosal mass in the left posterior buccal mucosa...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28776575/an-oral-cavity-squamous-cell-carcinoma-quantitative-histomorphometric-based-image-classifier-of-nuclear-morphology-can-risk-stratify-patients-for-disease-specific-survival
#8
Cheng Lu, James S Lewis, William D Dupont, W Dale Plummer, Andrew Janowczyk, Anant Madabhushi
Oral cavity squamous cell carcinoma is the most common type of head and neck carcinoma. Its incidence is increasing worldwide, and it is associated with major morbidity and mortality. It is often unclear which patients have aggressive, treatment refractory tumors vs those whose tumors will be more responsive to treatment. Better identification of patients with high- vs low-risk cancers could help provide more tailored treatment approaches and could improve survival rates while decreasing treatment-related morbidity...
August 4, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28771820/oral-tumors-in-children-diagnosis-and-management
#9
Razieh Khanmohammadi, Fatemeh Mir, Ghazaleh Baniebrahimi, Hamed Mirzaei
Oral tumors are one of important tumors which could be associated with serious problems in infant and children. It has been showed that a variety of cellular and molecular pathways including genetics and epigenetics mechanisms (e.g. chromosomal alterations, and microRNA) involved in pathogenesis events present in oral tumors. Identification of these pathways could contribute to better treatment of oral tumor patients. Early detection is one of key steps in management of oral tumors which could contribute to improve clinical outcomes and better treatment of infant with oral tumors...
August 3, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28770444/benefits-of-marriage-on-relative-and-conditional-relative-cancer-survival-differ-between-males-and-females-in-the-usa
#10
Ray M Merrill, Erin Johnson
PURPOSE: The purpose of the paper is to assess the influence of marital status on conditional relative survival of cancer according to sex. METHODS: Analyses involved 779,978 males and 1,032,868 females diagnosed with 1 of 13 cancer types between 2000 and 2008, and followed through 2013. Data are from the Surveillance, Epidemiology, and End Results (SEER) Program. Regression models were adjusted for age, sex, race, and tumor stage. RESULTS: Five-year relative survival conditional on years already survived is higher among married patients with less lethal cancers (oral cavity and pharynx, colon and rectum, breast, urinary bladder, kidney and renal pelvis, melanoma of the skin, thyroid, lymphoma)...
August 2, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28770159/peripheral-odontogenic-myxoma-in-a-12-year-old-girl-a-rare-entity
#11
Sampada Kanitkar, Mamata Kamat, Sridevi Tamagond, Aniruddha Varekar, Uma Datar
Peripheral odontogenic myxoma is a rare odontogenic tumor representing an extra osseous counterpart of central odontogenic myxoma. It is commonly seen in gingiva between the 3rd and 4th decades of life and appears predominantly in females. Compared to central odontogenic myxoma, it is a less aggressive, slow-growing lesion with a low recurrence rate. However, close postoperative follow-up is required because of the unlimited growth potential of incompletely removed lesions. It shares many features with other soft tissue myxoid proliferations occurring in the oral cavity and hence needs to be differentiated from them...
June 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28761209/extranodal-non-hodgkin-s-lymphoma-of-the-oral-cavity-a-case-report
#12
Babyamma Raghavan Varun, Nettiyat Oommen Varghese, Trivandrum Thanappan Sivakumar, Anna Palliath Joseph
Lymphomas are solid malignant tumors having a wide spectrum of clinical and pathological features. Non-Hodgkin's lymphoma (NHL) is a subtype of lymphoma with two-thirds of the cases presenting as lymph node enlargement. The remaining one third of NHL cases has been reported in the extranodal sites, including the gastro intestinal tract, Waldeyer's ring, bone, skin, and brain. Intraoral non-Hodgkin's lymphoma is uncommon and may affect either the jaw bones or occur within the soft tissues of the oral cavity...
July 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28760853/survival-of-head-and-neck-cancer-cells-relies-upon-lzk-kinase-mediated-stabilization-of-mutant-p53
#13
Zoe C Edwards, Eleanor W Trotter, Pedro Torres-Ayuso, Phil Chapman, Henry M Wood, Katherine Nyswaner, John Brognard
Head and neck squamous cell carcinoma (HNSCC) includes epithelial cancers of the oral and nasal cavity, larynx, and pharynx and accounts for ~350,000 deaths/year worldwide. Smoking-related HNSCC is associated with few targetable mutations but is defined by frequent copy number alteration, the most common of which is gain at 3q. Critical 3q target genes have not been conclusively determined for HNSCC. Here we present data indicating that MAP3K13 (encoding LZK) is an amplified driver gene in HNSCC. Copy number gain at 3q resulted in increased MAP3K13 mRNA in HNSCC tumor samples and cell lines...
July 31, 2017: Cancer Research
https://www.readbyqxmd.com/read/28759046/ezh2-mediated-upregulation-of-ros1-oncogene-promotes-oral-cancer-metastasis
#14
C-H Shih, Y-J Chang, W-C Huang, T-H Jang, H-J Kung, W-C Wang, M-H Yang, M-C Lin, S-F Huang, S-W Chou, E Chang, H Chiu, T-Y Shieh, Y-J Chen, L-H Wang, L Chen
Current anti-epidermal growth factor receptor (EGFR) therapy for oral cancer does not provide satisfactory efficacy due to drug resistance or reduced EGFR level. As an alternative candidate target for therapy, here we identified an oncogene, ROS1, as an important driver for oral squamous cell carcinoma (OSCC) metastasis. Among tumors from 188 oral cancer patients, upregulated ROS1 expression strongly correlated with metastasis to lung and lymph nodes. Mechanistic studies uncover that the activated ROS1 results from highly expressed ROS1 gene instead of gene rearrangement, a phenomenon distinct from other cancers...
July 31, 2017: Oncogene
https://www.readbyqxmd.com/read/28752518/the-color-of-cancer-margin-guidance-for-oral-cancer-resection-using-elastic-scattering-spectroscopy
#15
Gregory A Grillone, Zimmern Wang, Gintas P Krisciunas, Angela C Tsai, Vishnu R Kannabiran, Robert W Pistey, Qing Zhao, Eladio Rodriguez-Diaz, Ousama M A'Amar, Irving J Bigio
OBJECTIVES/HYPOTHESIS: To evaluate the usefulness of elastic scattering spectroscopy (ESS) as a diagnostic adjunct to frozen section analysis in patients with diagnosed squamous cell carcinoma of the oral cavity. STUDY DESIGN: Prospective analytic study. METHODS: Subjects for this single institution, institutional review board-approved study were recruited from among patients undergoing surgical resection for squamous cell cancer of the oral cavity...
July 28, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28749282/oronasal-squamous-cell-carcinomas-in-fran%C3%A3-ois-langurs-trachypithecus-francoisi
#16
John A Flanders, Michelle E Thompson, Mitzi J Palazzolo, Michael M Garner, Matthew Reed, Donna M Ialeggio, Matti Kiupel, William H Westra, Kathryn C Gamble
Squamous cell carcinomas (SCCs) are common oronasal tumors in nonhuman primates. In this study, 11 cases of oronasal SCC in François' langurs ( Trachypithecus francoisi ) are described. Five initial cases were discovered on review of the North American François' langur studbook, with a potential familial pattern observed. The studbook was used to identify related individuals, and records were requested for review. Six additional cases were documented, and samples from all cases were submitted for microscopic review, as well as polymerase chain reaction (PCR), immunohistochemistry (IHC), and in situ hybridization (ISH), for generic papillomaviruses and PCR for herpesviruses because either virus may cause SCC in humans and other nonhuman primates...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28745907/role-of-fdg-pet-ct-scan-in-head-and-neck-cancer-patients
#17
Mehrdad Bakhshayesh Karam, Abtin Doroudinia, Ali Safavi Nainee, Fatemeh Kaghazchi, Abbas Yousefi Koma, Payam Mehrian, Farahnaz Agha Hossein
INTRODUCTION: PET/CT scan has an emerging role in head and neck oncology with a few well-established indications, including: detection of unknown primary tumor site, tumor staging, radiotherapy planning, treatment response assessment and detection of recurrent disease. The purpose of this study is reporting PET/CT findings in head and neck cancer patients to emphasize its role in head and neck oncology. MATERIALS AND METHODS: In a retrospective study, we reviewed our PET/CT database and found 94 patients with primary head and neck cancer...
July 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28741409/foxp3-expression-in-lymph-node-metastases-in-patients-with-head-and-neck-cancer
#18
Mehtap Boduc, Marion Roessler, Robert Mandic, Christoph Netzer, Christian Güldner, Ute Walliczek-Dworschak, Boris A Stuck, Magis Mandapathil
INTRODUCTION: The prevalence and activity of regulatory T cells in patients with cancer correlates with poor prognosis. These cells are characterized by their expression of Forkhead box protein-3 (Foxp3). Squamous cell carcinoma is the most prevalent type of cancer in the head and neck region with overall poor survival rates, also due to early spread of metastatic cells. MATERIAL AND METHODS: Primary tumor specimens as well as lymph node specimens harvested during neck dissection of 65 patients with a diagnosis of HNSCC were subjected to immunohistochemical and H-score analysis of Foxp3 expression...
July 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28736959/in-vivo-raman-spectroscopy-assisted-early-identification-of-potential-second-primary-recurrences-in-oral-cancers-an-exploratory-study
#19
Akshat Malik, Aditi Sahu, S P Singh, Atul Deshmukh, Pankaj Chaturvedi, Deepa Nair, Sudhir Nair, C Murali Krishna
BACKGROUND: Higher rates of local recurrences and second primaries, ascribable to field cancerization, are known problem in oral cancers. The present study explored utility of identification of potential recurrences by Raman spectroscopy, which has been shown to identify oral precancers, cancers, and field cancerization in humans and micro-sized mechanical irritation-induced tumors in animals. METHODS: Raman spectra were acquired from tumor and contralateral normal mucosa in 99 patients with oral cancer who were then followed up for appearance of clinically apparent cancerous lesions...
July 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28730764/mtor-deregulation-in-oral-cavity-squamous-cell-carcinoma
#20
Nicholas S Mastronikolis, Evangelos Tsiambas, Theodoros A Papadas, Panagiotis P Fotiades, Athanasios T Papadas, Stylianos N Mastronikolis, Ioannis Kastanioudakis, Vasileios Ragos
Signal transduction pathways consist of a variety of inter- and intra-cellular molecules. They act as supporting mechanisms for cell survival and homeostasis. Among them, the phosphatidylinositol 3-kinase (PI3K)/tumor suppressor phosphatase and tensin homologue deleted on chromosome ten (PTEN)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway plays a crucial role in regulating normal cell growth based on growth factor receptors (GFRs) interaction, including epidermal GFR (type II-HER2) and insulin GFR (IGF)...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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