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Oral cavity tumors

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https://www.readbyqxmd.com/read/29442455/oral-mucositis-and-saliva-iga-igg-and-igm-concentration-during-anti-tumor-treatment-in-children-suffering-from-acute-lymphoblastic-leukemia
#1
Elżbieta J Pels
BACKGROUND: Oral mucositis is a problem occurring within the oral cavity, which is the most difficult to deal with during anti-tumor treatment. The first symptom reported by the patient is discomfort. Salivary immunoglobulins play an important role in pathological processes occurring in the oral cavity. OBJECTIVES: The study objective was to assess the occurrence of oral mucositis and to assess changes in the saliva IgA, IgG, and IgM concentration in children with acute lymphoblastic leukemia during antitumor treatment...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442085/an-insight-into-diagnosis-of-a-hidden-entity-impacted-food-material
#2
Humeera M Mulla, Nupura Vibhute, Rajendra Baad, N D Shashikiran, Mustaq Parker, R C Parmod, Uzma Belgaumi, Vidya Kadashetti, Sushma Bommanawar
Introduction: Foreign bodies and tissue reactions to foreign materials are commonly encountered in the oral cavity. Exogenous materials causing foreign body reactions may be metallic (amalgam) or nonmetallic (suture materials, vegetable matter). Implantation of food particles in the oral tissues has been known to cause reactive lesions such as oral pulse granuloma. Implantation could be through extraction sockets, deep periodontal pockets, associated with tumor growth, interdental areas of teeth, unfilled root canals, and grossly decayed teeth...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29440792/ancient-schwannoma-of-gingiva-a-rare-case-report
#3
Manas Bajpai, Nilesh Pardhe
Oral schwannomas (OSs) are rare benign tumors of oral cavity derived from peripheral nerve sheath, composed of proliferation of schwann cells in a characteristic pattern. AS are long-standing lesions which exhibit degenerative changes and atypia due to which they could be mistaken for malignancy. The mean age of occurrence of AS in oral cavity is 43 years, and no case of oral AS has been reported in a pediatric patient so far. Here, we present a rare case of AS of oral cavity in a 10-year-old male child.
May 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29433990/follow-up-after-curative-treatment-for-oral-squamous-cell-carcinoma-a-critical-appraisal-of-the-guidelines-and-a-review-of-the-literature
#4
REVIEW
M T Brands, P A Brennan, A L M Verbeek, M A W Merkx, S M E Geurts
The oral cavity is the commonest subsite of head and neck squamous cell carcinoma (HNSCC). Because of the rising incidence and increasing survival, more patients will be enrolled in a routine follow-up program. This review gives an overview of the evidence and guideline recommendations concerning follow-up after oral squamous cell carcinoma (OSCC). There is limited evidence concerning the effectiveness of follow-up after OSCC. This lack of evidence is reflected in a variation in guideline recommendations with respect to test interval and duration (i...
January 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29423555/second-malignancies-after-hematopoietic-stem-cell-transplantation
#5
REVIEW
Ivetta Danylesko, Avichai Shimoni
Second malignancies are a rare but well-defined late complication after autologous and allogeneic hematopoietic stem-cell transplantation (SCT). Solid malignancies occur in up to 15% of patients 15 years after SCT with myeloablative conditioning, with no plateau in the incidence rates. They are responsible for 5-10% of late deaths after SCT. The incidence is increased with advanced age at SCT. The major risk factors are the use of total body irradiation, which is associated with adenocarcinomas and with chronic graft-versus-host disease which is associated with squamous cell cancers...
February 8, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29423108/cancer-immunogenomic-approach-to-neoantigen-discovery-in-a-checkpoint-blockade-responsive-murine-model-of-oral-cavity-squamous-cell-carcinoma
#6
Paul Zolkind, Dariusz Przybylski, Nemanja Marjanovic, Lan Nguyen, Tianxiang Lin, Tanner Johanns, Anton Alexandrov, Liye Zhou, Clint T Allen, Alexander P Miceli, Robert D Schreiber, Maxim Artyomov, Gavin P Dunn, Ravindra Uppaluri
Head and neck squamous cell carcinomas (HNSCC) are an ideal immunotherapy target due to their high mutation burden and frequent infiltration with lymphocytes. Preclinical models to investigate targeted and combination therapies as well as defining biomarkers to guide treatment represent an important need in the field. Immunogenomics approaches have illuminated the role of mutation-derived tumor neoantigens as potential biomarkers of response to checkpoint blockade as well as representing therapeutic vaccines...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29423024/a-novel-multiplex-detection-array-revealed-systemic-complement-activation-in-oral-squamous-cell-carcinoma
#7
Juliane Gallenkamp, Gerrit Spanier, Elisabeth Wörle, Markus Englbrecht, Michael Kirschfink, Roman Greslechner, Regine Braun, Nicole Schäfer, Richard J Bauer, Diana Pauly
Oral squamous cell carcinoma (OSCC) is one of the most common tumors within the oral cavity. Early diagnosis and prognosis tools are urgently needed. This study aimed to investigate the activation of the complement system in OSCC patients as potential biomarker. Therefore, an innovative complement activation array was developed. Characterized antibodies detecting the complement activation specific epitopes C3a, C5a and sC5b-9 along with control antibodies were implemented into a suspension bead array. Human serum from a healthy (n = 46) and OSCC patient (n = 57) cohort were used to investigate the role of complement activation in oral tumor progression...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415020/the-evolution-of-the-epidemiological-landscape-of-head-and-neck-cancer-in-italy-is-there-evidence-for-an-increase-in-the-incidence-of-potentially-hpv-related-carcinomas
#8
Paolo Boscolo-Rizzo, Manuel Zorzi, Annarosa Del Mistro, Maria Cristina Da Mosto, Giancarlo Tirelli, Carlotta Buzzoni, Massimo Rugge, Jerry Polesel, Stefano Guzzinati
The current study aimed to investigate the incidence and survival patterns of HNSCCs arising from different anatomic sites, potentially related (the oropharynx) or unrelated (the oral cavity, the larynx/hypopharynx) to HPV, to provide clues on possible growing impact of HPV in the epidemiology of HNSCC in Italy. Epidemiological data were retrieved from ten long-term Cancer Registries covering a population of 7.8 million inhabitants. Trends were described by means of the estimated annual percent change (APC) stratified by age and gender, and compared between HPV-related and HPV-unrelated anatomical sites...
2018: PloS One
https://www.readbyqxmd.com/read/29413278/multicenter-study-of-carbon-ion-radiation-therapy-for-adenoid-cystic-carcinoma-of-the-head-and-neck-subanalysis-of-the-japan-carbon-ion-radiation-oncology-study-group-j-cros-study-1402-hn
#9
Nor Shazrina Sulaiman, Yusuke Demizu, Masashi Koto, Jun-Ichi Saitoh, Hiroaki Suefuji, Hiroshi Tsuji, Tatsuya Ohno, Yoshiyuki Shioyama, Tomoaki Okimoto, Takashi Daimon, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
PURPOSE: To retrospectively analyze the treatment outcomes of carbon-ion radiation therapy for adenoid cystic carcinoma (ACC) of the head and neck at 4 active carbon-ion facilities in Japan. METHODS AND MATERIALS: A total of 289 patients who underwent carbon-ion radiation therapy for histology-proven ACC of the head and neck at 4 institutions in Japan between November 2003 and December 2014 were included in this study. RESULTS: Median patient age was 58 years (range, 12-83 years)...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29410763/oral-peripheral-nerve-sheath-tumors-a-clinicopathological-and-immunohistochemical-study-of-32-cases-in-a-brazilian-population
#10
Talita Franco, Silas-Antonio-Juvencio de Freitas Filho, Laís-Borges Muniz, Paulo-Rogério de Faria, Adriano-Mota Loyola, Sérgio-Vitorino Cardoso
Background: Oral peripheral nerve sheath tumors (OPNSTs) are reactive or neoplastic diseases that develop from proliferation of the nerve itself or their limiting sheaths. Here we describe the clinicopathologic data of OPNSTs observed in a sample of the Brazilian population and evaluate the expression of molecules associated with neural biology to determine their usefulness in the diagnosis. Material and Methods: Descriptive study of cases diagnosed as OPNSTs, from the Pathology Laboratory at the School of Dentistry/ Federal University of Uberlandia, followed by an immunohistochemical study of S-100, CD57, neurofilament protein (NFP) and epithelial membrane antigen (EMA)...
December 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29408295/kir2ds1-2ds5-3ds1-and-kir2dl5-are-associated-with-the-risk-of-head-and-neck-squamous-cell-carcinoma-in-iranians
#11
Shaghik Barani, Bijan Khademi, Elham Ashouri, Abbas Ghaderi
BACKGROUND: Activatingandinhibitory KIRreceptors (aKIR, iKIR) control the development and function of NK cells whose function alterations adjust the tumor microenvironment immunity. This research was conducted to determine the KIRs gene impact on genetic predisposition to Head and Neck Squamous Cell Carcinoma (HNSCC) in Iranians. METHODS: KIR genotyping usingsequence-specific primers-polymerase chain reaction (SSP-PCR) method was performed to identify the presence of all 16 KIRgenes in 285 HNSCC patients, including laryngeal, oral cavity and pharyngeal SCC and 273 controls (CNs)...
February 2, 2018: Human Immunology
https://www.readbyqxmd.com/read/29406335/fish-shellfish-intake-and-the-risk-of-head-and-neck-cancer
#12
Kathleen M McClain, Patrick T Bradshaw, Nikhil K Khankari, Marilie D Gammon, Andrew F Olshan
Fish intake and other dietary sources of omega-3 fatty acids have been shown to be associated with a reduced risk for some cancers. Although previous studies of head and neck cancer have reported associations with different dietary factors, including reduced risks for fruits and vegetables and putatively healthy dietary patterns, associations specific to fish intake are unclear. This study investigated the association between fish/shellfish intake and risk of squamous cell carcinoma of the head and neck (SCCHN) using data from the Carolina Head and Neck Cancer Epidemiology Study, a population-based case-control study conducted in 46 North Carolina counties with cases recruited from 2002 through 2006...
February 5, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29404898/induction-chemotherapy-with-the-extreme-regimen-in-frail-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinoma
#13
Valérie Cochin, Erwan de Mones, Laurence Digue, Muriel Garcia-Ramirez, Charles Dupin, Claire Majoufre, Philipe Fernandez, Amaury Daste
BACKGROUND: Induction chemotherapy (IC) with TPF (docetaxel, cisplatin, 5FU) for locally advanced head and neck squamous cell carcinoma (LAHNSCC) is limited to fit patients. OBJECTIVE: We conducted a retrospective cohort study to assess the use of the EXTREME regimen (platinum-based therapy, 5FU, cetuximab) as IC in frail patients with LAHNSCC. PATIENTS AND METHODS: Retrospective analysis of all consecutive patients with unresectable LAHNSCC treated with the EXTREME regimen, with or without 5FU as IC, from two French centers from 2008 to 2015...
February 5, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29402730/clinical-complications-in-the-application-of-polyglycolic-acid-sheets-with-fibrin-glue-after-resection-of-mucosal-lesions-in-oral-cavity
#14
Kohei Okuyama, Souichi Yanamoto, Tomofumi Naruse, Yuki Sakamoto, Satoshi Rokutanda, Seigo Ohba, Izumi Asahina, Masahiro Umeda
OBJECTIVES: Covering open wounds with a polyglycolic acid (PGA) sheet using fibrin glue after resection of oral mucosal lesions is reportedly useful. We focused on clinical complications of this procedure: development of marked granuloma-like neoplasm (GLN) and abnormal postoperative bleeding (APB) on the resected region. STUDY DESIGN: The characteristics of 100 cases with PGA sheet application after the resection of oral mucosal lesion were examined retrospectively by the medical records and/or oral photographs at our department between 2010 and 2016...
December 29, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29402408/cc-223-inhibits-human-head-and-neck-squamous-cell-carcinoma-cell-growth
#15
Jun-Ying Wang, Xin Jin, Xin Zhang, Xiao-Feng Li
mTOR over-activation is associated with the progression of head and neck squamous cell carcinoma (HNSCC). CC-223 is a novel and potent mTOR kinase inhibitor. Its activity against human HNSCC cells is studied here. In established SCC-9 cells and primary human oral cavity carcinoma (OCC) cells, CC-223 treatment at only nM concentrations significantly inhibited survival, proliferation and cell cycle progression. Furthermore, CC-223 provoked apoptosis activation in human HNSCC cells. CC-223 is more efficient in killing HNSCC cells than other known Akt-mTOR inhibitors: RAD001, MK-2206 and AZD-2014...
January 31, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29393297/the-histologic-risk-model-is-a-useful-and-inexpensive-tool-to-assess-risk-of-recurrence-and-death-in-stage-i-or-ii-squamous-cell-carcinoma-of-tongue-and-floor-of-mouth
#16
Namita Sinha, Matthew H Rigby, Michael L McNeil, S Mark Taylor, Jonathan Rb Trites, Robert D Hart, Martin J Bullock
Surgery is the mainstay of treatment for low-stage (stage I/II, ie, T1N0/T2N0) squamous cell carcinoma of oral cavity. However, a significant percentage of low-stage squamous cell carcinoma of oral cavity will develop local recurrence and disease-related mortality. In this study, we stratified 64 patients with low-stage of oral tongue and floor of mouth patients into high-, intermediate- and low-risk categories based on existing histologic risk model. The classification of these risk categories was based on presence or absence of perineural invasion and evaluation of tumor-host junction for worst pattern of invasion and lymphocytic host response...
February 2, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29393250/risk-factors-for-distant-metastasis-in-patients-with-oral-cavity-squamous-cell-carcinoma-undergoing-surgical-treatment
#17
Felipe Toyama Aires, Chin Shien Lin, Leandro Luongo Matos, Marco Aurélio Vamondes Kulcsar, Claudio Roberto Cernea
OBJECTIVE: The aim of this study is to investigate the clinical and pathological factors related to distant metastasis in patients with oral cavity squamous cell carcinoma (OCSCC) undergoing surgery. STUDY DESIGN: A retrospective data review was conducted on patients who underwent primary surgery for OCSCC at the Instituto do Cancer do Estado de São Paulo (ICESP) between 2009 and 2015. Distant metastasis rates were calculated and predictive factors were determined by the Cox proportional-hazards model...
January 23, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29390536/osteoma-with-actinomycosis-in-a-nasal-cavity-a-case-report
#18
Jong Seung Kim, Sang Jae Noh, Soon Ho Ryu
RATIONALE: Osteoma with actinomycosis is a very rare disease in the nasal cavity. PATIENT CONCERNS: We report a case of a 17-year-old female student who presented with nasal obstruction and rhinorrhea for 6 months. DIAGNOSES: The preoperative finding was osteoma covered with yellowish polypoid material. INTERVENTIONS: We performed endoscopic sinus surgery, which included excision of the tumor and medication with oral penicillin for 8 weeks...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390454/low-grade-myofibroblastic-sarcoma-of-the-orbit-a-case-report-and-literature-review
#19
Shikun Zhang, Ying Ma, Tie Ma, Zhiming Wang
RATIONALE: Low-grade myofibroblastic sarcoma (LGMS) is a malignant lesion composed of myofibroblasts. It is an uncommon tumor of unknown etiology that mainly develops in the bone or soft tissue and is most often reported in the head and neck, particularly in the tongue and oral cavity. PATIENT CONCERNS: A 2-year-old girl, previously well and with no significant medical history or family history of other diseases, presented with a 2-week painless swelling of the right orbit...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29387511/extraosseous-ewing-s-sarcoma-of-the-pancreas-an-uncommon-but-treatable-disease
#20
Muhammad W Saif, Kristin Kaley
Extraosseous Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is a rare but aggressive and malignant tumor, and has been reported in various sites such as the lungs, biliary tract, kidney, prostate, stomach, esophagus, oral cavity, salivary glands, urinary bladder, uterus, cervix, gonads, and vagina. However, the pancreas is considered to be an extremely uncommon site and only a handful of cases have been published to date. We present here another case of a pancreatic ES/PNET. Our case intensifies the importance to recognize this rare type of tumor in the pancreas as there is a broad spectrum of tumors with a similar morphology that includes sheets of small, round blue cells...
November 26, 2017: Curēus
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