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D-cycloserine bipolar

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https://www.readbyqxmd.com/read/27738380/treatment-resistant-depression-with-loss-of-antidepressant-response-rapid-acting-antidepressant-action-of-dextromethorphan-a-possible-treatment-bridging-molecule
#1
Edward C Lauterbach
Dextromethorphan (DM) may have ketamine-like rapid-acting, treatment-resistant, and conventional antidepressant effects.(1,2) This reports our initial experience with DM in unipolar Major Depressive Disorder (MDD). A patient with treatment-resistant MDD (failing adequate trials of citalopram and vortioxetine) with loss of antidepressant response (to fluoxetine and bupropion) twice experienced a rapid-acting antidepressant effect within 48 hours of DM administration and lasting 7 days, sustained up to 20 days with daily administration, then gradually developing labile loss of antidepressant response over the ensuing 7 days...
August 15, 2016: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/26132675/single-dose-ketamine-followed-by-daily-d-cycloserine-in-treatment-resistant-bipolar-depression
#2
LETTER
Joshua T Kantrowitz, Batsheva Halberstam, James Gangwisch
No abstract text is available yet for this article.
June 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/25566387/a-randomized-controlled-trial-of-cognitive-remediation-and-d-cycloserine-for-individuals-with-bipolar-disorder
#3
Nicholas Jk Breitborde, Spencer C Dawson, Cindy Woolverton, David Dawley, Emily K Bell, Kaila Norman, Angelina Polsinelli, Beth Bernstein, Pamela Mirsky, Christine Pletkova, Felix Grucci, Carly Montoya, Bernard Nanadiego, Ehsan Sarabi, Michael DePalma, Francisco Moreno
BACKGROUND: Cognitive remediation (CR) has shown significant promise in addressing the cognitive deficits that accompany serious mental illness. However, this intervention does not appear to completely ameliorate the cognitive deficits that accompany these illnesses. D-cycloserine (DCS), an NMDA receptor partial agonist, has been shown to enhance the therapeutic benefits of learning-based psychosocial interventions for psychiatric disorders. Thus, the goal of this study is to examine the utility of combining cognitive remediation and d-cycloserine in the treatment of cognitive deficits among individuals with bipolar disorder...
2014: BMC Psychology
https://www.readbyqxmd.com/read/24410564/targeting-of-nmda-receptors-in-the-treatment-of-major-depression
#4
REVIEW
Yong-Hui Dang, Xian-Cang Ma, Ji-Chun Zhang, Qian Ren, Jin Wu, Cheng-Ge Gao, Kenji Hashimoto
Major depressive disorder (MDD) is a common, recurrent mental illness that affects millions of people worldwide. Accumulating evidence suggests that the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptors, plays an important role in the neurobiology and treatment of this disease. Currently, the non-competitive NMDA receptor antagonist ketamine is considered as one of the most attractive candidate drugs in therapy of treatment-resistant depression. A recent study demonstrated ketamine's rapid antidepressant activity in patients with treatment-resistant MDD and bipolar disorder...
2014: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/22412961/deletion-of-glutamate-delta-1-receptor-in-mouse-leads-to-aberrant-emotional-and-social-behaviors
#5
Roopali Yadav, Subhash C Gupta, Brandon G Hillman, Jay M Bhatt, Dustin J Stairs, Shashank M Dravid
The delta family of ionotropic glutamate receptors consists of glutamate δ1 (GluD1) and glutamate δ2 (GluD2) receptors. While the role of GluD2 in the regulation of cerebellar physiology is well understood, the function of GluD1 in the central nervous system remains elusive. We demonstrate for the first time that deletion of GluD1 leads to abnormal emotional and social behaviors. We found that GluD1 knockout mice (GluD1 KO) were hyperactive, manifested lower anxiety-like behavior, depression-like behavior in a forced swim test and robust aggression in the resident-intruder test...
2012: PloS One
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