Orit Uziel, Andrew A Kanner, Einat Beery, Sapir Lev, Meir Lahav, Suzana Horn-Fichman, Sagi Har Nof, Yuseph Laviv, Shlomit Yust Katz, Alexandra Amiel, Ramez Abu Shkara, Mustafa Siddeeq, Adva Levi-Barda, Pia Raanani, Yaron Sela, Zvi Cohen, Tali Siegal
BACKGROUND: In order to proliferate indefinitely, all tumors require a telomere maintenance mechanism. The expression of human telomerase reverse transcriptase (hTERT) enables telomere maintenance and provides cancer cells with limitless replicative potential. As such, it may serve as an attractive biomarker for oncogenic activity. This study explored whether a liquid biopsy that analyses blood derived exosomal hTERT transcript (e-hTERT-trans) may serve as such a biomarker in gliomas and meningiomas when compared to healthy controls...
December 28, 2023: Cancer Medicine