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Qualitative Methodology

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https://www.readbyqxmd.com/read/28213479/impact-of-searching-clinical-trial-registries-in-systematic-reviews-of-pharmaceutical-treatments-methodological-systematic-review-and-reanalysis-of-meta-analyses
#1
Marie Baudard, Amélie Yavchitz, Philippe Ravaud, Elodie Perrodeau, Isabelle Boutron
Objective To evaluate the impact of searching clinical trial registries in systematic reviews.Design Methodological systematic review and reanalyses of meta-analyses.Data sources Medline was searched to identify systematic reviews of randomised controlled trials (RCTs) assessing pharmaceutical treatments published between June 2014 and January 2015. For all systematic reviews that did not report a trial registry search but reported the information to perform it, the World Health Organization International Trials Registry Platform (WHO ICTRP search portal) was searched for completed or terminated RCTs not originally included in the systematic review...
February 17, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28212131/psychometric-properties-of-a-new-instrument-for-assessing-irrational-thoughts-in-burn-victims-scale-of-irrational-thoughts-after-burn-injuries
#2
Zahra Zare, Homayoun Sadeghi-Bazargani, Fatemeh Ranjbar, Diana Stark Ekman, Mostafa Farahbakhsh, Hemmat Maghsoudi, Robert Ekman, Farideh Nasiri
The objective of this study was to develop and evaluate a scale for assessing irrational thoughts among burned patients. The present study was mixed (qualitative-methodologic) which was performed in several stages such as investigating similar or related scales, interviewing with patients and psychologists. Content validity was calculated by modified KAPPA basis on relevance and clarity. The reliability of the scale was measured using internal consistency and the test-retest method. To determine the construct validity, exploratory factor analysis approach using maximum likelihood extraction with varimax rotation was conducted...
February 9, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28209517/inadvertent-hypothermia-and-mortality-in-critically-ill-adults-systematic-review-and-meta-analysis
#3
REVIEW
Panagiotis Kiekkas, Fotini Fligou, Michael Igoumenidis, Nikolaos Stefanopoulos, Evangelos Konstantinou, Vasilios Karamouzos, Diamanto Aretha
OBJECTIVE: Considering that inadvertent hypothermia (IH) is common in Intensive Care Unit (ICU) patients and can be followed by severe complications, this systematic review identified, appraised and synthesized the published literature about the association between IH and mortality in adults admitted to the ICU. DATA SOURCES: By using key terms, literature searches were conducted in Pubmed, CINAHL, Cochrane Library, Web of Science and EMBASE. REVIEW METHODS: According to PRISMA guidelines, articles published between 1980-2016 in English-language, peer-reviewed journals were considered...
February 13, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28208252/high-confidence-qualitative-identification-of-organophosphorus-nerve-agent-adducts-to-human-butyrylcholinesterase
#4
Thomas P Mathews, Melissa D Carter, Darryl Johnson, Samantha L Isenberg, Leigh Ann Graham, Jerry D Thomas, Rudolph C Johnson
In this study, a data-dependent, high-resolution tandem mass spectrometry (ddHRMS/MS) method capable of detecting all organophosphorus nerve agent (OPNA) adducts to human butyrylcholinesterase (BChE) was developed. After an exposure event, immunoprecipitation from blood with a BChE-specific antibody and digestion with pepsin produces a nine amino acid peptide containing the OPNA adduct. Signature product ions of this peptic BChE nonapeptide (FGES*AGAAS) offer a route to broadly screen for OPNA exposure. Taking this approach on an HRMS instrument identifies biomarkers, including unknowns, with high mass accuracy...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28208098/-don-t-think-i-m-going-to-leave-you-over-it-accounts-of-changing-hepatitis-c-status-among-couples-who-inject-drugs
#5
Jake Rance, Carla Treloar, Suzanne Fraser, Joanne Bryant, Tim Rhodes
BACKGROUND: While the health-related benefits of intimate partnership are well documented, little attention has been paid to couples exposed to high levels of social stigma and exclusion. In this project we investigated an important site of stigma for partnerships by collecting accounts of changing hepatitis C (HCV) status ("sero-change") among couples that inject drugs. We explored what these accounts reveal about the meaning of HCV for these couples, and how this understanding contributes to our collective efforts at prevention and care...
January 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28202021/-i-passed-the-test-evidence-of-diagnostic-misconception-in-the-recruitment-of-population-controls-for-an-h3africa-genomic-study-in-cape-town-south-africa
#6
Francis Masiye, Bongani Mayosi, Jantina de Vries
BACKGROUND: Advances in genetic and genomic research have introduced challenges in obtaining informed consent for research in low and middle-income settings. However, there are only few studies that have explored challenges in obtaining informed consent in genetic and genomic research in Africa and none in South Africa. To start filling this gap, we conducted an empirical study to investigate the efficacy of informed consent procedures for an H3Africa genomic study on Rheumatic Heart Disease (RHDGen) at the University of Cape Town in South Africa...
February 15, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28199923/assistance-at-mealtimes-in-hospital-settings-and-rehabilitation-units-for-patients-65years-from-the-perspective-of-patients-families-and-healthcare-professionals-a-mixed-methods-systematic-review
#7
REVIEW
Deborah Edwards, Judith Carrier, Jane Hopkinson
BACKGROUND: Malnutrition is one of the key issues affecting the health of older people (>65years). With an aging population the problem is expected to increase further since the prevalence of malnutrition increases with age. Studies worldwide have identified that some older patients with good appetites do not receive sufficient nourishment because of inadequate feeding assistance. Mealtime assistance can enhance nutritional intake, clinical outcomes and patient experience. OBJECTIVES/AIM: To determine the effectiveness of meal time assistance initiatives for improving nutritional intake and nutritional status for older adult patients (>65years) in hospital settings and rehabilitation units...
January 30, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28198955/-un-receptiveness-in-interactions-with-professionals-experiences-of-parents-of-children-with-retinopathy-of-prematurity
#8
Beatriz Castanheira Facio, Bruna de Souza Lima Marski, Ieda Harumi Higarashi, Maira Deguer Misko, Aline Oliveira Silveira, Monika Wernet
OBJECTIVE: To analyze the influence of health professionals' receptiveness on parental care of children with retinopathy of prematurity (ROP). METHOD: A qualitative study developed under the theoretical framework of Symbolic Interactionism and using a narrative research methodology. Six women and three men, being parents of children with retinopathy of prematurity were individually interviewed in depth. RESULTS: From the scope of information, emotions and their rights, the parents experienced receptiveness from some professionals and unreceptiveness from others...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28198509/multivariate-approach-in-popcorn-genotypes-using-the-ward-mlm-strategy-morpho-agronomic-analysis-and-incidence-of-fusarium-spp
#9
R N F Kurosawa, A T do Amaral Junior, F H L Silva, A Dos Santos, M Vivas, S H Kamphorst, G F Pena
The multivariate analyses are useful tools to estimate the genetic variability between accessions. In the breeding programs, the Ward-Modified Location Model (MLM) multivariate method has been a powerful strategy to quantify variability using quantitative and qualitative variables simultaneously. The present study was proposed in view of the dearth of information about popcorn breeding programs under a multivariate approach using the Ward-MLM methodology. The objective of this study was thus to estimate the genetic diversity among 37 genotypes of popcorn aiming to identify divergent groups associated with morpho-agronomic traits and traits related to resistance to Fusarium spp...
February 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28197788/self-care-of-people-with-chronic-obstructive-pulmonary-disease-a-meta-synthesis
#10
REVIEW
Marco Clari, Maria Matarese, Dhurata Ivziku, Maria Grazia De Marinis
BACKGROUND: Self-care in people with chronic obstructive pulmonary disease (COPD) can improve health-related quality of life, reduce hospital admissions and decrease dyspnoea. OBJECTIVE: This review aimed to systematically identify, evaluate and synthesise the qualitative literature on the self-care behaviours and strategies used by people with COPD. METHODS: The Joanna Briggs Institute (JBI) meta-aggregative method was followed. An electronic search of six relevant databases was conducted...
February 14, 2017: Patient
https://www.readbyqxmd.com/read/28197557/doubly-charged-trimeric-cluster-ions-effective-in-mutual-chiral-recognition-of-tadalafil-and-three-proton-pump-inhibitors
#11
Lu Wang, Yunfeng Chai, Wenquan Zhu, Yuanjiang Pan, Cuirong Sun, Su Zeng
Mutual chiral recognition of four stereoisomers of tadalafil and three pairs of enantiomers of proton pump inhibitors (PPIs) including pantoprazole, lansoprazole, and omeprazole, as well as quantitative analysis of enantiomeric excess is achieved on the basis of the competitive fragmentation of doubly charged trimeric Ni(II) cluster ions. Compared with a singly charged trimeric cluster ion, a doubly charged trimeric cluster ion was proved efficient in the recognition of chiral drugs with one or multiple chiral centers, due to its rich fragmentation ions...
February 15, 2017: Analyst
https://www.readbyqxmd.com/read/28194883/understanding-process-and-context-in-breastfeeding-support-interventions-the-potential-of-qualitative-research
#12
Dawn Leeming, Joyce Marshall, Abigail Locke
Considerable effort has been made in recent years to gain a better understanding of the effectiveness of different interventions for supporting breastfeeding. However, research has tended to focus primarily on measuring outcomes and has paid comparatively little attention to the relational, organizational, and wider contextual processes that may impact delivery of an intervention. Supporting a woman with breastfeeding is an interpersonal encounter that may play out differently in different contexts, despite the apparently consistent aims and structure of an intervention...
February 14, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28193290/transitional-care-for-formerly-incarcerated-persons-with-hiv-protocol-for-a-realist-review
#13
Jenkin Tsang, Sharmistha Mishra, Janet Rowe, Patricia O'Campo, Carolyn Ziegler, Fiona G Kouyoumdjian, Flora I Matheson, Ahmed M Bayoumi, Shatabdy Zahid, Tony Antoniou
BACKGROUND: Little is known about the mechanisms that influence the success or failure of programs to facilitate re-engagement with health and social services for formerly incarcerated persons with HIV. This review aims to identify how interventions to address such transitions work, for whom and under what circumstances. METHODS: We will use realist review methodology to conduct our analysis. We will systematically search electronic databases and grey literature for English language qualitative and quantitative studies of interventions...
February 13, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28193182/de-novo-mutational-profile-in-rb1-clarified-using-a-mutation-rate-modeling-algorithm
#14
Varun Aggarwala, Arupa Ganguly, Benjamin F Voight
BACKGROUND: Studies of de novo mutations offer great promise to improve our understanding of human disease. After a causal gene has been identified, it is natural to hypothesize that disease relevant mutations accumulate within a sub-sequence of the gene - for example, an exon, a protein domain, or at CpG sites. These assessments are typically qualitative, because we lack methodology to assess the statistical significance of sub-gene mutational burden ultimately to infer disease-relevant biology...
February 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28192790/systemic-pharmacologic-therapies-for-low-back-pain-a-systematic-review-for-an-american-college-of-physicians-clinical-practice-guideline
#15
Roger Chou, Richard Deyo, Janna Friedly, Andrea Skelly, Melissa Weimer, Rochelle Fu, Tracy Dana, Paul Kraegel, Jessica Griffin, Sara Grusing
Background: A 2007 American College of Physicians guideline addressed pharmacologic options for low back pain. New evidence and medications have now become available. Purpose: To review the current evidence on systemic pharmacologic therapies for acute or chronic nonradicular or radicular low back pain. Data Sources: Ovid MEDLINE (January 2008 through November 2016), Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and reference lists...
February 14, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28188679/quantitative-flow-cytometry-concerns-and-recommendations-in-clinic-and-research
#16
REVIEW
Olga Mizrahi, Eliran Ish-Shalom, Michal Baniyash, Yair Klieger
BACKGROUND: Quantitative flow cytometry (QFCM) can be an important element within the developing toolbox for clinical diagnostics which relies on precise and rapid tests that provide a conclusive answer for physicians. The FC technology combines all of these features. Until recently, this imperative discipline was based on qualitative assessments of cell populations. However, due to the enormous advancement in FC technology, which allows the quantification of a number of antigens on cell surface and within the cells by units of median fluorescence intensity (MFI), this method becomes meaningful and fits the clinical needs...
February 11, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28187945/impact-of-ambient-temperature-on-morbidity-and-mortality-an-overview-of-reviews
#17
Xuping Song, Shigong Wang, Yuling Hu, Man Yue, Tingting Zhang, Yu Liu, Jinhui Tian, Kezheng Shang
The objectives were (i) to conduct an overview of systematic reviews to summarize evidence from and evaluate the methodological quality of systematic reviews assessing the impact of ambient temperature on morbidity and mortality; and (ii) to reanalyse meta-analyses of cold-induced cardiovascular morbidity in different age groups. The registration number is PROSPERO-CRD42016047179. PubMed, Embase, the Cochrane Library, Web of Science, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Global Health were systematically searched to identify systematic reviews...
February 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28187772/integrating-consumer-engagement-in-health-and-medical-research-an-australian-framework
#18
Caroline L Miller, Kathy Mott, Michael Cousins, Stephanie Miller, Anne Johnson, Tony Lawson, Steve Wesselingh
BACKGROUND: Quality practice of consumer engagement is still in its infancy in many sectors of medical research. The South Australian Health and Medical Research Institute (SAHMRI) identified, early in its development, the opportunity to integrate evidence-driven consumer and community engagement into its operations. PROCESS: SAHMRI partnered with Health Consumers Alliance and consumers in evidence generation. A Partnership Steering Committee of researchers and consumers was formed for the project...
February 10, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28186951/incentives-and-disincentives-for-treating-of-depression-and-anxiety-in-ontario-family-health-teams-protocol-for-a-grounded-theory-study
#19
Rachelle Ashcroft, Matthew Menear, Jose Silveira, Simone Dahrouge, Kwame McKenzie
INTRODUCTION: There is strong consensus that prevention and management of common mental disorders (CMDs) should occur in primary care and evidence suggests that treatment of CMDs in these settings can be effective. New interprofessional team-based models of primary care have emerged that are intended to address problems of quality and access to mental health services, yet many people continue to struggle to access care for CMDs in these settings. Insufficient attention directed towards the incentives and disincentives that influence care for CMDs in primary care, and especially in interprofessional team-based settings, may have resulted in missed opportunities to improve care quality and control healthcare costs...
November 14, 2016: BMJ Open
https://www.readbyqxmd.com/read/28186462/posttraumatic-growth-following-the-loss-of-a-pet
#20
Cori Bussolari, Janice Habarth, Satoko Kimpara, Rachel Katz, France Carlos, Amy Chow, Hisao Osada, Yukiko Osada, Betty J Carmack, Nigel P Field, Wendy Packman
The current study examined Posttraumatic Growth (PTG) experienced by bereaved pet owners in the United States, French-Canada, Japan, and Hong Kong following the death of their pet. Using qualitative methodology, we analyzed responses of participants who answered "yes" to a question about experiencing PTG and explored to what extent the cross-cultural responses mapped onto the five factors of the Posttraumatic Growth Inventory (PTGI). For the U.S. sample, 58% of responses mapped onto the PTGI. For French-Canada, 72% of responses mapped onto the PTGI...
January 1, 2017: Omega
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