Megan R Sutherland, Lina Gubhaju, Lynette Moore, Alison L Kent, Jane E Dahlstrom, Rosemary S C Horne, Wendy E Hoy, John F Bertram, M Jane Black
Nephrogenesis is ongoing at the time of birth for the majority of preterm infants, but whether postnatal renal development follows a similar trajectory to normal in utero growth is unknown. Here, we examined tissue collected at autopsy from 28 kidneys from preterm neonates, whose postnatal survival ranged from 2 to 68 days, including 6 that had restricted intrauterine growth. In addition, we examined kidneys from 32 still-born gestational controls. We assessed the width of the nephrogenic zone, number of glomerular generations, cross-sectional area of the renal corpuscle, and glomerular maturity and morphology...
July 2011: Journal of the American Society of Nephrology: JASN