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pulmonary neonatal autopsy

Muhammad Ayaz Mustufa, Munir Ahmed Sheikh, Ijaz-Ul-Haque Taseer, Syed Jamal Raza, Muhammad Sohail Arshad, Tasleem Akhter, Ghazala Mohyuddin Arain, Sultana Habibullah, Sohail Safdar, Rukhsana Firdous, Muhammad Adnan
BACKGROUND: Considering the fact that Pakistan is amongst the countries with very high neonatal mortality rates, we conducted a research study to determine the possible causes and characteristics of neonates presenting dead to the emergency department of tertiary public health care facilities of Pakistan using verbal autopsies. METHODS: A descriptive case series study was conducted in emergency department/pediatrics ward/neonatal ward/nursery unit of ten tertiary care public health facilities, situated in seven major cities of Pakistan from November, 2011 to June, 2013...
February 2017: World Journal of Pediatrics: WJP
Praveen Chandrasekharan, Rafal Kozielski, Vasantha H S Kumar, Munmun Rawat, Veena Manja, Changxing Ma, Satyan Lakshminrusimha
Inhaled nitric oxide (iNO) is being increasingly used in preterm infants < 34 weeks with hypoxemic respiratory failure (HRF) and/or pulmonary hypertension (PH). Objective To evaluate the risk factors, survival characteristics, and lung histopathology in preterm infants with PH/HRF. Methods Retrospective chart review was conducted to determine characteristics of 93 preterm infants treated with iNO in the first 28 days and compared with 930 matched controls. Factors associated with survival with preterm HRF and smooth muscle actin from nine autopsies were evaluated...
September 14, 2016: American Journal of Perinatology
Meaghan M Mackesy, Brian T Kalish, Wayne Tworetzky, Stephen Sanders, Alyaa Al-Ibraheemi, Louise Wilkins-Haug, James Lock, Audrey Marshall, Carol B Benson
Fetuses with hypoplastic left heart syndrome (HLHS) and intact atrial septum are a particular subset of HLHS neonates with high perinatal mortality. The reported mortality in these patients is 50% to 70%, even with prenatal diagnosis. Prenatal left atrial and pulmonary venous hypertension results in abnormal pulmonary vascular and parenchymal development. The goal of this study was to compare the sonographic appearance of the lungs in fetuses with HLHS/intact atrial septum to neonatal outcome and/or pathology in cases where in utero intervention was performed to open the atrial septum...
August 29, 2016: Ultrasound Quarterly
Khairul Zainun, Kirsten Hope, Andrew G Nicholson, Marta Cecilia Cohen
Abnormal muscularization of intra acinar pulmonary arteries is a histological hallmark of persistent pulmonary hypertension of newborn (PPHN), an uncommon disease with high morbidity and mortality. PPHN presents with signs of respiratory distress immediately following birth. The disease is multi-factorial in origin and can be idiopathic as well associated with a variety of conditions such as congenital heart disease and both congenital and acquired lung diseases. We report two cases presenting as sudden unexpected death in late neonatal period (SUDI) showing abnormal muscularization of acinar pulmonary arteries reminiscent of PPHN...
August 30, 2016: Pediatric and Developmental Pathology
Maha Saleh, Ioana Miron, Hadeel Al-Rukban, David Chitayat, Marjan M Nezarati
No abstract text is available yet for this article.
September 2016: Prenatal Diagnosis
Gabriel Nuncio Benevides, Patricia Picciarelli de Lima, Aloisio Felipe-Silva, Silvana Maria Lovisolo, Ana Maria Andrello Gonçalves Pereira de Melo
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare, developmental lung disorder, which has been increasingly reported. This entity usually presents as neonatal persistent pulmonary hypertension that is unresponsive to treatment, and is known to be uniformly fatal. Recent discoveries in the genetic field, and intensive treatments, may change the natural course of this disease, permitting easier diagnosis and giving new hope for the dismal prognosis. The authors present two cases of siblings, with two years of difference, from different fathers - one of them was a first-degree and the other a second-degree cousin of the mother...
January 2015: Autopsy & case reports
Lynette K Rogers, Mary Robbins, Duaa Dakhlallah, Zhaogang Yang, L James Lee, Madison Mikhail, Gerard Nuovo, Gloria S Pryhuber, Gerald McGwin, Clay B Marsh, Trent E Tipple
RATIONALE: Bronchopulmonary dysplasia remains a significant cause of neonatal morbidity; however, the identification of novel targets to predict or prevent the development of bronchopulmonary dysplasia remains elusive. Proper microRNA (miR)-17∼92 cluster is necessary for normal lung development, and alterations in expression are reported in other pulmonary diseases. The overall hypothesis for our work is that altered miR-17∼92 cluster expression contributes to the molecular pathogenesis of bronchopulmonary dysplasia...
October 2015: Annals of the American Thoracic Society
Stephanie J Bissel, Roland N Auer, Cheng-Hsuan Chiang, Julia Kofler, Geoffrey H Murdoch, W Allan Nix, Michael Painter, Maxime Richer, Hervé Sartelet, Guoji Wang, Clayton A Wiley
Human parechovirus 3 (HPeV3) is a picornavirus associated with neurologic disease in neonates. Human parechovirus 3 infection of preterm and term infants is associated with seizures and destructive periventricular white matter lesions. Despite unremarkable cerebrospinal fluid (CSF), HPeV3 RNA can be amplified from CSF and nasopharyngeal and rectal swabs. We report pathologic findings in 2 autopsy cases of infants with active HPeV3 infection. Both children were born approximately 1 month premature and were neurologically intact but, after a few weeks, developed seizures and radiologic evidence of white matter lesions...
August 2015: Journal of Neuropathology and Experimental Neurology
Siaka Koné, Thomas Fürst, Fabienne N Jaeger, Emmanuel L J C Esso, Nahoua Baïkoro, Kouamé A Kouadio, Lukas G Adiossan, Fabien Zouzou, Louis I Boti, Marcel Tanner, Jürg Utzinger, Bassirou Bonfoh, Daouda Dao, Eliézer K N'Goran
BACKGROUND: Current vital statistics from governmental institutions in Côte d'Ivoire are incomplete. This problem is particularly notable for remote rural areas that have limited access to the health system. OBJECTIVE: To record all deaths from 2009 to 2011 and to identify the leading causes of death in the Taabo health and demographic surveillance system (HDSS) in south-central Côte d'Ivoire. DESIGN: Deaths recorded in the first 3 years of operation of the Taabo HDSS were investigated by verbal autopsy (VA), using the InterVA-4 model...
2015: Global Health Action
Yukako Kawasaki, Masami Makimoto, Keiko Nomura, Akihiro Hoshino, Takeru Hamashima, Mitsuteru Hiwatari, Atsuko Nakazawa, Junko Takita, Taketoshi Yoshida, Hirokazu Kanegane
We describe a neonate with abdominal distension, massive hepatomegaly, and high serum neuron-specific enolase level suggestive of congenital neuroblastoma. The patient died of pulmonary hemorrhage after therapy. Autopsy revealed that the tumor cells in the liver indicated acute megakaryocytic leukemia with the RBM15-MKL1 fusion gene.
March 2015: Clinical Case Reports
Momodou Jasseh, Stephen R C Howie, Pierre Gomez, Susana Scott, Anna Roca, Mamady Cham, Brian Greenwood, Tumani Corrah, Umberto D'Alessandro
OBJECTIVE: To estimate and evaluate the cause-of-death structure and disease-specific mortality rates in a rural area of The Gambia as determined using the InterVA-4 model. DESIGN: Deaths and person-years of observation were determined by age group for the population of the Farafenni Health and Demographic Surveillance area from January 1998 to December 2007. Causes of death were determined by verbal autopsy (VA) using the InterVA-4 model and ICD-10 disease classification...
2014: Global Health Action
Nurul Alam, Hafizur R Chowdhury, Subhash C Das, Ali Ashraf, P Kim Streatfield
OBJECTIVE: Population-based information on causes of death (CoD) by age, sex, and area is critical for countries with limited resources to identify and address key public health issues. This study analysed the demographic surveillance and verbal autopsy (VA) data to estimate age- and sex-specific mortality rates and cause-specific mortality fractions in two well-defined rural populations within the demographic surveillance system in Abhoynagar and Mirsarai subdistricts, located in different climatic zones...
2014: Global Health Action
Stefania Tudorache, Luminiţa Cristina Chiuţu, Dominic Gabriel Iliescu, Raluca Georgescu, George Alin Stoica, Cristiana Eugenia Simionescu, Eugen Florin Georgescu, Răducu Nicolae Nemeş
PURPOSE: To evaluate the perinatal results for fetuses and neonates with left-sided congenital diaphragmatic hernia (CDH) and the role of the prenatal diagnosis in the pregnancy outcome. MATERIALS AND METHODS: We reviewed data from fetuses and neonates with left-sided CDH, managed from January 2009 and December 2013 in the University Clinic Hospital, Craiova, Romania. The following data were analyzed: the gestational age at the time of diagnosis, fetal karyotyping, presence of associated structural malformations, ultrasound (US) data (circumference and area of right lung, lung-to-head ratio - LHR, observed/expected LHR, hepatic herniation), the type of antenatal care, the pregnancy outcome, the place of birth and the conventional autopsy data, if performed...
2014: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
V Arreo Del Val, A Avila-Alvarez, L R Schteffer, F Santos, L Deiros, M J Del Cerro
Alveolar capillary dysplasia with misalignment of the pulmonary veins (ACD/MPV) is a rare and lethal cause of refractory pulmonary hypertension of the newborn. We describe the clinical course of a neonate with refractory pulmonary hypertension diagnosed with ACD/MPV, aortic coarctation and other not previously reported associated malformations.
October 2014: Journal of Perinatology: Official Journal of the California Perinatal Association
Irene Scheimberg
The incidence of opportunistic invasive infections has risen dramatically in the last years and morbidity and mortality remains high. Invasive aspergillosis has been described in immunocompromised patients (bone marrow transplant, haematological malignancies, solid transplant organ recipients). Neonates and in particular those born prematurely, are at especial risk of infection due to the immaturity of their immune system and the use of corticoids and antibiotics in neonatal intensive care units. Aspergillus species are ubiquitous, being present in the soil and dust...
October 2014: Pathology
Mehmet Halil Çeliksoy, Burak Tander, Nazik Aşılıoğlu, Yakup Sancar Barış, Alişan Yıldıran
Pulmonary hypoplasia is characterized by decrease in the number and size of pulmonary airways, alveoli and vessels. In autopsy, pulmonary hypoplasia is a major cause of death in neonates and infants. The disease is usually diagnosed in childhood period. Although it mimics lung parenchymal disease and other vascular abnormalities radiologically, it is easily recognized with computed tomography angiography and magnetic resonance angiography examinations. In 50% of patients, concomitant cardiovascular, neuromuscular, gastrointestinal tract, and urogenital anomalies are also available...
October 2015: Clinical Respiratory Journal
E C Castro, W T Parks, C Galambos
INTRODUCTION: The mammalian lung possesses the highest level of angiotensin converting enzyme (ACE) amongst all the organs. ACE is known to generate angiotensin (AT)-II from AT-I and to regulate serum bradykinin level, thereby controlling blood pressure. Recent data, however, indicate a role for ACE derived AT-II in angiogenesis, pulmonary hypertension, and neonatal lung disease. The ontogeny of ACE in humans has not been investigated. We studied pulmonary ACE expression during human lung development and in human bronchopulmonary dysplasia (BPD)...
October 2014: Pediatric Pulmonology
Wanwisa Himakhun, Kitiwan Rojnueangnit, Sariya Prachukthum
Osteogenesis imperfecta (OI) is an inherited disorder of type I collagen synthesis with an estimate incidence of I in 100,000 live births. Among all types, OI type II is the most severe type with perinatal death. The authors describes a male neonate with characteristic features of osteogenesis imperfect type II, including short crumpling limbs, beaded ribs, poorly bony ossification and blue sclera. Autopsy with histological study revealed not only multiple fractures, but pulmonary hypoplasia and intracerebral hemorrhages were also present...
January 2012: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
M Dzieniecka, K Krystosiak, A Kulig
Adequate pulmonary development at birth is the major determinant of postnatal outcome in the perinatal period. Lung hypoplasia is a poorly defined condition. The aim of this study was to investigate expression of Ki-67 in human fetuses with pulmonary hypoplasia compared to fetuses without pulmonary pathology and malformations of other organs used as controls. The analysis comprised 149 formalin-fixed and paraffin-embedded tissue sections from the files of the Clinical Pathology Department of the Research Institute of Polish Mother's Memorial Hospital in Lodz...
June 2013: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Prajakta A Gupte, Pradeep Vaideeswar, Bhuvaneshwari M Kandalkar
OBJECTIVE: Nephropathy is a known complication in cyanotic congenital heart disease (CCHD). This study was undertaken for an objective analysis of histopathological changes of cyanotic nephropathy at autopsy. DESIGN: Retrospective case records studied. SETTING: Tertiary care teaching hospital affiliated to medical college in Mumbai, India. PATIENTS AND METHODS: The renal histopathological findings of 50 consecutive autopsies in patients with CCHD were compared with 25 age-matched controls...
July 2014: Congenital Heart Disease
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