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hypertension, atherosclerosis, carotid intima media thickness

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https://www.readbyqxmd.com/read/29766804/cyclophilin-a-a-predictive-biomarker-of-carotid-stenosis-in-cerebral-ischemic-stroke
#1
Chen-Shu Chang, Shih-Li Su, Chen-Ling Kuo, Ching-Shan Huang, Wan-Min Tseng, Song-Shei Lin, Chin-San Liu
BACKGROUND: Cyclophilin A plays a pathogenic role in the development and progression of atherosclerosis, which can be assessed by measuring carotid intima-media thickness. The primary aim of this study was to examine the interaction between plasma Cyclophilin A level and carotid intima-media thickness in patients with acute ischemic stroke. METHOD: Plasma concentration of Cyclophilin A was measured on admission in 66 consecutive patients who had been hospitalized for acute cerebral stroke and in 52 case-control subjects without a history of acute stroke...
May 16, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29761548/variation-of-carotid-intima-media-thickness-with-body-mass-index-in-healthy-adults-of-black-african-descent
#2
Adesola Abiodun Asaleye, Kolawole Thomas Braimoh, Olalekan Ibukun Oyinloye, Christianah Mopelola Asaleye, Adeleye Dorcas Omisore
OBJECTIVES: Studies have shown that common carotid intima media thickness (CIMT) measured by B-mode sonography increases with body mass index (BMI) among subjects with cardiovascular diseases in different populations. However, association of body fat and subclinical atherosclerosis in the absence of these cardiovascular diseases is understudied. We aimed to evaluate the correlation between BMI and CIMT in a healthy adult population of black African ancestry. METHODS: This is a cross-sectional prospective study in 300 consecutive apparently healthy subjects aged 18 to 70 years without history of hypertension, dyslipidemia, diabetes mellitus, and renal disease...
May 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29748187/complete-and-partial-lcat-deficiency-are-differentially-associated-with-atherosclerosis
#3
Federico Oldoni, Damiano Baldassarre, Samuala Castelnuovo, Alice Ossoli, Mauro Amato, Julian van Capelleveen, G Kees Hovingh, Eric de Groot, Andrea Bochem, Sara Simonelli, Simone Barbieri, Fabrizio Veglia, Guido Franceschini, Jan Albert Kuivenhoven, Adriaan G Holleboom, Laura Calabresi
Background -Lecithin:cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma. Its role in the supposed protection from atherogenesis remains unclear since mutations in LCAT causing Fish-Eye Disease (FED) or Familial LCAT Deficiency (FLD) have been reported to be associated with more or instead less carotid atherosclerosis, respectively. This discrepancy may be associated with the loss of cholesterol esterification on only apolipoprotein (apo) A-I (FED) or on both apoA-I and apoB-containing lipoproteins (FLD), an aspect that has thus far not been investigated...
May 10, 2018: Circulation
https://www.readbyqxmd.com/read/29739796/prevalence-of-carotid-plaque-in-a-63-to-65-year-old-norwegian-cohort-from-the-general-population-the-ace-akershus-cardiac-examination-1950-study
#4
Håkon Ihle-Hansen, Thea Vigen, Hege Ihle-Hansen, Ole Morten Rønning, Trygve Berge, Bente Thommessen, Magnus Nakrem Lyngbakken, Eivind Bjørkan Orstad, Steve Enger, Ståle Nygård, Helge Røsjø, Arnljot Tveit
BACKGROUND: New data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular risk control in the population may have changed patterns of carotid arterial wall disease and actual prevalence of established cardiovascular disease. We investigated the prevalence of atherosclerotic carotid plaques and carotid intima-media thickness (cIMT) and their relation to cardiovascular risk factors in a middle-aged cohort from the general population...
May 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29724293/plasma-preptin-levels-are-decreased-in-patients-with-essential-hypertension
#5
Huaiqiu Cai, Qingan Liu, Xiaoqiu Dong, Yawen Cai, Jinlai Yao, Yue Liu
The pancreatic hormone preptin amplifies glucose-mediated insulin secretion, and we investigated its circulating levels in patients with essential hypertension and possible association with carotid atherosclerosis. Ninety-eight patients were divided into hypertensive and control groups. Relationships between plasma preptin levels, clinical parameters, and carotid artery intima-media thickness (IMT) were analyzed. Plasma preptin levels were significantly lower in the hypertensive group than in the control group (1930...
May 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29643525/-association-between-chronic-periodontitis-and-carotid-intima-media-thickness-of-middle-aged-and-older-adults-in-shijingshan-community-of-beijing
#6
Y Liu, Q X Luan
OBJECTIVE: To investigate the relationship between periodontal disease and subclinical atherosclerosis in middle-aged and older adults in Shijingshan community of Beijing. METHODS: In 2005-2010, a total of 830 middle-aged and older adults were recruited from Shijingshan community of Beijing, who were divided into two groups by severity of periodontitis. A questionnaire, periodontal examination, blood biochemical examination, carotid intima-media thickness (CIMT), including common carotid artery (CCA-IMT), internal carotid artery (ICA-IMT) and carotid bifurcation (CB-IMT), were measured of each subject...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29622590/carotid-atherosclerosis-detected-by-ultrasonography-a-national-cross-sectional-study
#7
Xiaojun Wang, Wenzhen Li, Fujian Song, Longde Wang, Qian Fu, Shiyi Cao, Yong Gan, Wei Zhang, Wei Yue, Feng Yan, Wenhuan Shi, Xiaoli Wang, Hong Zhang, Hao Zhang, Zhihong Wang, Zuxun Lu
BACKGROUND: Carotid atherosclerosis (CA) is a reflector of generalized atherosclerosis that is associated with systemic vascular disease. Data are limited on the epidemiology of carotid lesions in a large, nationally representative population sample. We aimed to evaluate the prevalence of CA detected by carotid ultrasonography and related risk factors based on a national survey in China. METHODS AND RESULTS: A total of 107 095 residents aged ≥40 years from the China National Stroke Prevention Project underwent carotid ultrasound examination...
April 5, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29611041/time-of-exposure-to-night-work-and-carotid-atherosclerosis-a-structural-equation-modeling-approach-using-baseline-data-from-elsa-brasil
#8
Aline Silva-Costa, Joanna Guimarães, Dora Chor, Maria de Jesus Mendes da Fonseca, Isabela Bensenor, Itamar Santos, Sandhi Barreto, Rosane Härter Griep
PURPOSE: The study of cardiovascular diseases (CVD) associated with night work is difficult due to the long period required for conditions to manifest and the healthy-worker effect. Analyzing asymptomatic pre-clinical changes in the atherosclerotic process is a way to assess the pathways between exposure to night work and CVD. AIM: To evaluate the associations between night work and subclinical atherosclerosis measured by carotid intima-media thickness (CIMT) using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)...
April 2, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29603491/assessment-of-epicardial-fat-and-carotid-intima-media-thickness-in-gestational-hypertension
#9
Cihan Altin, Mustafa Yilmaz, Hasmet M Ozsoy, Esin Gezmis, Serdar Balci, Mustafa A Tekindal, Leyla E Sade, Haldun Muderrisoglu
AIM: Gestational hypertension (GHT) is a common disorder of pregnancy characterized by new onset hypertension without the presence of detectable proteinuria after 20 weeks of gestation. Epicardial fat thickness (EFT) and carotid intima media thickness (CIMT) are suggested as new predictors of subclinical atherosclerosis. Although the relationship between these parameters and essential hypertension has been demonstrated, this association in patients with GHT is still unknown. We aimed to investigate CIMT and EFT in patients with GHT...
March 30, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29594192/the-influence-of-nafld-on-the-risk-of-atherosclerosis-and-cardiovascular-diseases
#10
REVIEW
Kamila Wójcik-Cichy, Ewa Koślińska-Berkan, Anna Piekarska
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed countries and is associated with obesity, dyslipidaemia, diabetes, and metabolic syndrome. Atherosclerosis and cardiovascular diseases are also highly prevalent in this group of patients, due to the presence of shared risk factors. The incidences of coronary artery calcification, hypertension, aortic valve sclerosis, diastolic dysfunction, atherosclerotic plaques, and increased carotid intima-media thickness were more common in patients with NAFLD than in those without...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29582539/association-between-atherosclerosis-and-handgrip-strength-in-non-hypertensive-populations-in-india-and-japan
#11
Hirotomo Yamanashi, Bharati Kulkarni, Tansy Edwards, Sanjay Kinra, Jun Koyamatsu, Mako Nagayoshi, Yuji Shimizu, Takahiro Maeda, Sharon E Cox
AIM: Although several risk factors contribute to the development of sarcopenia, whether preclinical atherosclerosis contributes to the risk of sarcopenia is not established. The present cross-sectional study aimed to investigate if there is an association between preclinical atherosclerosis and muscle strength among two ethnic populations. METHODS: Participants included individuals aged ≥40 years and enrolled in the third follow-up examination of the Andhra Pradesh Children and Parents Study, India, and in the baseline assessments of the Nagasaki Islands Study, Japan...
March 26, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29555791/association-of-prehypertension-and-hyperhomocysteinemia-with-subclinical-atherosclerosis-in-asymptomatic-chinese-a-cross-sectional-study
#12
Bo Liu, Zhihao Chen, Xiaoqi Dong, Guangming Qin
OBJECTIVES: Comorbid hypertension and hyperhomocysteinemia is an important risk factor for carotid atherosclerotic plaque formation. We put forward the hypothesis that the subjects with comorbid prehypertension and hyperhomocysteinemia also had an increased risk of subclinical atherosclerosis, using carotid intima-media thickness (CIMT) as the marker of the atherosclerotic process. METHODS: A total of 4102 asymptomatic Chinese subjects aged 18-60 years were divided into four groups according to blood pressure (BP) and homocysteine (HCY) level: the control group without prehypertension or hyperhomocysteinemia, isolated prehypertension group, simple hyperhomocysteinemia group and prehypertension with hyperhomocysteinemia group...
March 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29553852/the-effect-of-cardiovascular-risk-factors-on-the-carotid-intima-media-thickness-in-an-old-aged-cohort-with-hypertension-a-longitudinal-evolution-with-4-year-follow-up-of-a-random-clinical-trial
#13
Xiao Xiao Zhao, Jinbo Liu, Hongwei Zhao, Yingyan Zhou, Lihong Li, Hongyu Wang
Hypertension is a generally accepted atherogenic risk factor. The aim of this prospective longitudinal study was to evaluate changes in carotid intima-media thickness (c-IMT) and explore the association of cardiovascular risk factors and the carotid intima thickness in adults with hypertension using standardized methods. We used data from a subgroup of Beijing Vascular Disease Patients Evaluation Study (BEST), a population-based study of community-dwelling adults. The c-IMT, biomarkers, and carotid-femoral-pulse wave velocity (PWV) were measured at baseline, and lifestyles such as smoking status, sleeping habits, and oil or salt intake level were determined with the use of a validated questionnaire in the follow-up...
March 19, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29536408/contribution-of-type-2-diabetes-mellitus-to-subclinical-atherosclerosis-in-subjects-with-morbid-obesity
#14
Stefanie R van Mil, L Ulas Biter, Gert-Jan M van de Geijn, Erwin Birnie, Martin Dunkelgrun, Jan N M IJzermans, Noelle van der Meulen, Guido H H Mannaerts, Manuel Castro Cabezas
INTRODUCTION: Type 2 diabetes mellitus (T2DM) and obesity are both related to increased risk of cardiovascular disease and mortality. Early atherosclerotic vascular changes can be detected by non-invasive tests like carotid artery intima-media thickness (cIMT) and pulse wave velocity (PWV). Both cIMT and PWV are significantly impaired in T2DM patients and in obese patients, but the additional effect of T2DM on these vascular measurements in obese subjects has not been evaluated. METHODS: Two hundred morbidly obese patients with or without T2DM were enrolled in a prospective cohort study and underwent extensive laboratory testing, including cIMT and PWV measurements...
March 13, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29531271/the-relation-of-blood-pressure-and-carotid-intima-media-thickness-with-the-glutathione-cycle-in-a-young-bi-ethnic-population-the-african-predict-study
#15
Caitlynd Myburgh, Hugo W Huisman, Catharina M C Mels
Oxidative stress has been implicated in the development of hypertension, arterial stiffness and atherosclerosis. Optimal functioning of the enzymatic antioxidant system is central to prevent increased oxidative stress and its consequences. We aimed to investigate the relationships of ambulatory blood pressure and carotid intima-media thickness with enzyme activities of the glutathione cycle in 396 young, black and white South Africans of the African-PREDICT study. Ambulatory blood pressure and carotid intima-media thickness were measured and glutathione peroxidase and glutathione reductase activities were analyzed...
March 12, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29517980/role-of-hypertension-in-progression-of-chronic-kidney-disease-in-children
#16
Smitha R Vidi
PURPOSE OF REVIEW: Hypertension is an independent risk factor for progression of chronic kidney disease (CKD) in children. Children with early CKD develop hypertension secondary to renal disease. This review aims to highlight recent advances that help us better understand the current role of hypertension in progression of CKD in children. RECENT FINDINGS: There is increasing evidence that children with CKD who have hypertension develop early atherosclerosis and cardiac adaptive changes...
April 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29505844/hepatitis-c-virus-eradication-by-direct-acting-antiviral-agents-improves-carotid-atherosclerosis-in-patients-with-severe-liver-fibrosis
#17
Salvatore Petta, Luigi Elio Adinolfi, Anna Ludovica Fracanzani, Francesca Rini, Rosalia Caldarella, Vincenza Calvaruso, Calogero Cammà, Marcello Ciaccio, Vito Di Marco, Stefania Grimaudo, Anna Licata, Aldo Marrone, Riccardo Nevola, Rosaria Maria Pipitone, Antonio Pinto, Luca Rinaldi, Daniele Torres, Antonino Tuttolomondo, Luca Valenti, Silvia Fargion, Antonio Craxì
BACKGROUND AND AIMS: Recent studies suggest an association between hepatitis C virus (HCV) infection and cardiovascular damage, including carotid atherosclerosis, with a possible effect of HCV clearance on cardiovascular outcomes. We aimed to examine whether HCV eradication by direct-acting antiviral agents (DAA) improves carotid atherosclerosis in HCV-infected patients with advanced fibrosis/compensated cirrhosis. MATERIALS AND METHODS: One hundred eighty-two consecutive patients with HCV and advanced fibrosis or compensated cirrhosis were evaluated...
March 2, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29501539/contribution-of-mthfr-gene-variants-in-lupus-related-subclinical-atherosclerosis
#18
Maira Giannelou, Andrianos Nezos, Sofia Fragkioudaki, Dimitra Kasara, Kyriaki Maselou, Nikolaos Drakoulis, Dimitris Ioakeimidis, Haralampos M Moutsopoulos, Clio P Mavragani
OBJECTIVE: Elevated concentrations of homocysteine have been previously identified as an independent risk factor for subclinical atherosclerosis in patients with systemic lupus erythematosus (SLE). Given that heightened homocysteine levels are known to be strongly influenced by genetic factors, in the current study we investigated the contribution of high homocysteine levels as well as of functional polymorphisms of the gene encoding for the enzyme 5, 10- methylenetetrahydrofolate reductase (MTHFR) to atherosclerotic disease characterizing SLE patients...
March 6, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29488543/association-of-traditional-cardiovascular-risk-factors-with-carotid-atherosclerosis-among-adults-at-a-teaching-hospital-in-south-western-nigeria
#19
Adeleye Dorcas Omisore, Olusola Comfort Famurewa, Morenikeji Adeyoyin Komolafe, Christiana Mopelola Asaleye, Michael Bimbola Fawale, Babalola Ishmael Afolabi
BACKGROUND: Traditional cardiovascular risk factors (CVRFs), which include age, gender, hypertension, diabetes mellitus, dyslipidaemia, smoking, alcohol consumption, chronic kidney disease and obesity, have been shown to be associated with atherosclerosis. We aimed to evaluate the impact of traditional CVRFs on carotid atherosclerosis (CA) in a sample of Nigerian adults. METHODS: We examined 162 subjects with traditional CVRFs in a cross-sectional study. Demographic and clinical data, including history of hypertension, diabetes mellitus, smoking, alcohol intake and chronic kidney disease, as well as systolic and diastolic blood pressure, weight and height were collected...
February 28, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29461943/is-low-dose-radiation-exposure-a-risk-factor-for-atherosclerotic-disease
#20
Paula Boaventura, Cecília Durães, Adélia Mendes, Natália Rios Costa, Inês Chora, Sara Ferreira, Emanuel Araújo, Pedro Lopes, Gilberto Rosa, Pedro Marques, Sofia Tavares, Vanessa Chaves, Paulo Bettencourt, Inês Oliveira, Francisco Costa, Isabel Ramos, Maria José Teles, João Tiago Guimarães, Manuel Sobrinho-Simões, Paula Soares
Nontargeted late effects of radiation include an increased risk of cardiovascular disease, although this is still debatable in the context of low-dose radiation. Tinea capitis patients treated in childhood with X rays to induce scalp epilation received a low dose of radiation to their carotids. To better clarify this issue, we evaluated carotid atherosclerosis in a cohort of such patients treated in 1950-1963 in Portugal. A group of 454 individuals randomly chosen from previously observed Portuguese tinea capitis patients and a control group mainly composed of their spouses (n = 280) were enrolled...
April 2018: Radiation Research
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