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hypertension, atherosclerosis, carotid intima media thickness

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https://www.readbyqxmd.com/read/27899079/vasopressin-related-copeptin-is-a-novel-predictor-of-early-endothelial-dysfunction-in-patients-with-adult-polycystic-kidney-disease
#1
Ismail Kocyigit, Mahmut Ilker Yilmaz, Ozkan Gungor, Eray Eroglu, Aydin Unal, Ozcan Orscelik, Bulent Tokgoz, Murat Sipahioglu, Ahmet Sen, Juan Jesús Carrero, Oktay Oymak, Jonas Axelsson
BACKGROUND: In this study, we examined the relative usefulness of serum copeptin levels as a surrogate marker of vasopressin (AVP) in adult polycystic kidney disease (ADPKD) by correlating it with baseline and longitudinal changes in markers of both renal function and common CVD manifestations (hypertensive vascular disease, atherosclerosis and endothelial dysfunction) that accompany the progression of this disease. METHODS: We studied a cohort of young and otherwise healthy ADPKD patients (n = 235) and measured cardiovascular function using flow-mediation dilatation (FMD), carotid intima media thickness (cIMT) and pulse wave velocity (PWV), as well as serum copeptin (commercial ELISA, a stable marker of AVP activity)...
November 30, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27859887/preclinical-atherosclerosis-at-the-time-of-pre-eclamptic-pregnancy-and-up-to-10-years-postpartum-systematic-review-and-meta-analysis
#2
REVIEW
Natasa M Milic, Jelena Milin-Lazovic, Tracey L Weissgerber, Goran Trajkovic, Wendy M White, Vesna D Garovic
OBJECTIVES: Preeclampsia, a pregnancy-specific hypertensive disorder, has been associated with cardiovascular risk factors and vascular changes, such as acute atherosis in placental blood vessels, which are similar to early-stage atherosclerosis. The objective of this study was to determine whether women with preeclampsia have increased atherosclerotic burden, as determined by carotid intima-media thickness (CIMT), when compared to women without preeclampsia. METHODS: We conducted a systematic review and meta-analysis of studies that reported CIMT, a non-invasive, ultrasound-based measure of subclinical atherosclerosis, in women who did vs...
November 18, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27812790/the-role-of-sleeve-gastrectomy-in-reducing-cardiovascular-risk
#3
Tromba Luciana, Tartaglia Francesco, Carbotta Sabino, Sforza Nadia, Pelle Fabio, Colagiovanni Vanessa, Carbotta Giovanni, Cavaiola Stefania, Casella Giovanni
BACKGROUND: Obesity is an independent cardiovascular risk factor and a catalyst of other cardiovascular risk factors, such as hypertension, dyslipidemia, type 2 diabetes mellitus (DM2) and metabolic syndrome. METHODS: We analyzed cardiovascular risk in obese patients before and after sleeve gastrectomy (SG). To this end, we studied changes in body mass index (BMI), blood chemistry parameters that characterize the risk of atherosclerosis and instrumental parameters (objective markers of this risk), namely intima-media thickness (IMT) and flow-mediated dilation (FMD), the latter reflecting endothelial function...
November 4, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27812055/carotid-intima-media-thickness-evaluation-by-ultrasound-comparison-amongst-healthy-diabetic-and-hypertensive-pakistani-patients
#4
Waseem Mirza, Mubashir Arain, Arif Ali, Vaqar Bari, Mirza Kazim, Kainat Fatima, Zafar Sajjad, Aziz Jiwani, Nadeem Ahmad
OBJECTIVE: To compare carotid Intima media thickness and atherosclerosis burden amongst healthy, diabetic and hypertensive Pakistani patients. METHODS: A cross-sectional study was carried out at the Department of radiology and family medicine, Aga Khan University Hospital Karachi from April 2014 to July 2015. Bilateral carotid ultrasound was done in 133 healthy adults, 65 hypertensive, 31 type-2 diabetic and 37 hypertensive with type-2 diabetes patients. Normal adults were matched for age and gender...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27759579/oral-magnesium-supplementation-improves-endothelial-function-and-attenuates-subclinical-atherosclerosis-in-thiazide-treated-hypertensive-women
#5
Ana Rosa Cunha, Jenifer D'El-Rei, Fernanda Medeiros, Bianca Umbelino, Wille Oigman, Rhian M Touyz, Mario F Neves
BACKGROUND: Epidemiological studies demonstrate an inverse association between serum magnesium and incidence of cardiovascular disease. Diuretics commonly cause hypomagneseamia. METHOD: We evaluated effects of magnesium supplementation on blood pressure (BP) and vascular function in thiazide-treated hypertensive women in a randomized, double-blind, clinical trial. Hypertensive women (40-65 years) on hydrochlorothiazide and mean 24-h BP at least 130/80 mmHg were divided into placebo and supplementation (magnesium chelate 600 mg/day) groups...
January 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27753963/os-10-02-effects-of-helicobacter-pylori-infection-on-atherosclerosis-with-hypertension-and-type-2-diabetes-mellitus-in-aged-population
#6
Zhendong Liu, Yingxin Zhao, Yuanli Dong, Biao Lu, Miaomiao Wei
OBJECTIVE: To explore the effects of Helicobacter pylori infection on atherosclerosis in patients with hypertension and type 2 diabetes mellitus (T2DM). DESIGN AND METHOD: 228 subjects (Mean age: 67.92 ± 7.51) were enrolled in this study. Whether or not did the patients infected with Hp by 14C-Urea Breath Test (14C-UBT). The participants were divided into infection-positive group and infection-negative group basing on the outcomes of 14C-UBT. Their Carotid-Radial pulse wave velocity(CrPWV) and Carotid intima media thickness(CIMT) were mornitored...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753885/ish-ada-06-intima-media-thickness-of-the-carotid-bulb-is-associated-with-worsening-of-orthostatic-hypotension-in-patients-with-metabolic-disorder
#7
Yusuke Kobayashi, Hideo Kobayashi, Hiroaki Ishiguro, Keisuke Yatsu, Tetsuya Fujikawa, Satoshi Umemura
OBJECTIVE: Though both carotid bulb and aortic arch are known to play important roles in regulation of blood pressure through modulation in baroreflex function, few studies have investigated the association of carotid bulb atherosclerosis and large arterial stiffness and orthostatic blood pressure change. DESIGN AND METHOD: Patients with metabolic disorder such as hypertension, dyslipidemia and diabetes mellitus underwent measurement of segment-specific carotid intima-media thickness (IMT) (as an index of atherosclerosis of carotid bulb), cardio-ankle vascular index (CAVI) (as an index for large arterial stiffness), heart rate variability (HRV) (as an index of baroreflex function) and sit-to-stand orthostatic blood pressure change (as a simple method for detecting orthostatic hypotension)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27697067/hypovitaminosis-d-is-associated-with-endothelial-dysfunction-in-patients-with-metabolic-syndrome
#8
Coskun U Oruc, Yunus E Akpinar, Shirkhan Amikishiyev, Ayse Kubat Uzum, Artur Salmaslioglu, Figen Gurdol, Beyhan Omer
OBJECTIVES: Recent research has shown that hypovitaminosis D may increase the risk of hypertension, vascular disease, diabetes mellitus, obesity and metabolic syndrome (MetS). Endothelial dysfunction (ED) is one of the key components of MetS which is associated with an imbalance between vasoactive substances such as nitric oxide (NO) and endothelins (ET). In this study, we assessed the association of 25(OH) D3 level with endothelial dysfunction and subclinical atherosclerosis in MetS patients...
October 2, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27663919/cardiovascular-comorbidities-in-patients-with-psoriasis-risk-profile-including-carotide-ultrasonography-assessed-in-hospital-based-case-control-study
#9
Jana Votrubova, Katerina Juzlova, Martina Dzambova, Jana Hercogova, Dana Gopfertova
Psoriasis is a chronic inflammatory disease, and its comorbidities have attracted serious interest in recent years. The evidence that psoriasis is associated with systemic inflammation and significantly higher incidence of cardiovascular risk factors has already been described. The results of published studies are highly variable, the conclusions are ambiguous, and further epidemiological studies are needed for validation of published data. Therefore, we initiated a project aimed at identifying the association with cardiovascular risk factors, including early stages of atherosclerosis, that represent important comorbidities in patients with psoriasis...
August 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27643360/os-10-02-effects-of-helicobacter-pylori-infection-on-atherosclerosis-with-hypertension-and-type-2-diabetes-mellitus-in-aged-population
#10
Zhendong Liu, Yingxin Zhao, Yuanli Dong, Biao Lu, Miaomiao Wei
OBJECTIVE: To explore the effects of Helicobacter pylori infection on atherosclerosis in patients with hypertension and type 2 diabetes mellitus (T2DM). DESIGN AND METHOD: 228 subjects (Mean age: 67.92 ± 7.51) were enrolled in this study. Whether or not did the patients infected with Hp by 14C-Urea Breath Test (14C-UBT). The participants were divided into infection-positive group and infection-negative group basing on the outcomes of 14C-UBT. Their Carotid-Radial pulse wave velocity(CrPWV) and Carotid intima media thickness(CIMT) were mornitored...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643208/ish-ada-06-intima-media-thickness-of-the-carotid-bulb-is-associated-with-worsening-of-orthostatic-hypotension-in-patients-with-metabolic-disorder
#11
Yusuke Kobayashi, Hideo Kobayashi, Hiroaki Ishiguro, Keisuke Yatsu, Tetsuya Fujikawa, Satoshi Umemura
OBJECTIVE: Though both carotid bulb and aortic arch are known to play important roles in regulation of blood pressure through modulation in baroreflex function, few studies have investigated the association of carotid bulb atherosclerosis and large arterial stiffness and orthostatic blood pressure change. DESIGN AND METHOD: Patients with metabolic disorder such as hypertension, dyslipidemia and diabetes mellitus underwent measurement of segment-specific carotid intima-media thickness (IMT) (as an index of atherosclerosis of carotid bulb), cardio-ankle vascular index (CAVI) (as an index for large arterial stiffness), heart rate variability (HRV) (as an index of baroreflex function) and sit-to-stand orthostatic blood pressure change (as a simple method for detecting orthostatic hypotension)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27629245/circulating-mir-92a-expression-level-in-patients-with-essential-hypertension-a-potential-marker-of-atherosclerosis
#12
Y Huang, S Tang, C Ji-Yan, C Huang, J Li, A-P Cai, Y-Q Feng
MicroRNAs (miRs) are key posttranscriptional regulators of gene expression in all eukaryotic cells and have a vital role in the evolution of hypertension and cardiovascular remodelling and, therefore, have emerged as potential biomarkers for cardiovascular disease. We assessed 240 participants, including 60 healthy volunteers with normal carotid intima-media thickness (nCIMT), 60 healthy volunteers with increased CIMT (iCIMT), 60 hypertensive patients with nCIMT and 60 hypertensive patients with iCIMT. All patients underwent measurements of CIMT, carotid-femoral pulse wave velocity (cfPWV) and ambulatory blood pressure (BP) monitoring...
September 15, 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/27619983/rationale-and-design-of-a-multicenter-randomized-controlled-study-to-evaluate-the-preventive-effect-of-ipragliflozin-on-carotid-atherosclerosis-the-protect-study
#13
Atsushi Tanaka, Toyoaki Murohara, Isao Taguchi, Kazuo Eguchi, Makoto Suzuki, Masafumi Kitakaze, Yasunori Sato, Tomoko Ishizu, Yukihito Higashi, Hirotsugu Yamada, Mamoru Nanasato, Michio Shimabukuro, Hiroki Teragawa, Shinichiro Ueda, Satoshi Kodera, Munehide Matsuhisa, Toshiaki Kadokami, Kazuomi Kario, Yoshihiko Nishio, Teruo Inoue, Koji Maemura, Jun-Ichi Oyama, Mitsuru Ohishi, Masataka Sata, Hirofumi Tomiyama, Koichi Node
BACKGROUND: Type 2 diabetes mellitus is associated strongly with an increased risk of micro- and macro-vascular complications, leading to impaired quality of life and shortened life expectancy. In addition to appropriate glycemic control, multi-factorial intervention for a wide range of risk factors, such as hypertension and dyslipidemia, is crucial for management of diabetes. A recent cardiovascular outcome trial in diabetes patients with higher cardiovascular risk demonstrated that a SGLT2 inhibitor markedly reduced mortality, but not macro-vascular events...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27556236/asymptomatic-atherosclerosis-in-primary-sj%C3%A3-gren-syndrome-correlation-between-low-ankle-brachial-index-and-autoantibodies-positivity
#14
Ana Beatriz Andrêo Garcia, Luciana Paula Dardin, Paulo Alexandre Minali, Adriano Czapkowsky, Sergio Aron Ajzen, Virginia Fernandes Moça Trevisani
BACKGROUND: Primary Sjögren syndrome is a chronic inflammatory autoimmune disease. The delay in diagnosis allows the establishment of a chronic inflammatory state, which makes primary Sjögren syndrome an interesting model for the study of atherosclerosis. OBJECTIVES: The aim of this study was to evaluate subclinical atherosclerosis in 49 patients with Sjögren syndrome using noninvasive methods. METHODS: We assessed traditional risk factors such as hypertension, diabetes, dyslipidemia, smoking, and family history of atherosclerosis...
September 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27508805/-op-1c-04-structural-and-functional-arterial-abnormalities-in-fibromuscular-dysplasia-are-in-the-continuum-of-hypertension-an-imaging-and-biomechanical-study
#15
L Marais, P Boutouyrie, H Khettab, C Boulanger, A Lorthiroir, M Frank, R Niarra, J Renard, Y Chambon, X Jeunemaitre, M Zidi, P-F Plouin, S Laurent, M Azizi
OBJECTIVE: Fibromuscular dysplasia (FMD) is a non-atherosclerotic non-inflammatory arterial disease, which occurs mostly in middle-aged women and affects medium-sized arteries. We previously showed abnormalities within common carotid artery (CCA) wall, with the presence of triple signal (TS) at ultrasound suggesting the presence of supplementary layers. We aimed at coupling TS presence with microconstituents of the vessel wall, derived from fitting of the pressure-diameter curve. DESIGN AND METHOD: We included 50 non-smoking patients with multifocal FMD, 50 essential hypertensive (EH) patients and 50 healthy subjects (HS) matched for age, sex, ethnicity and BP (EH and FD)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508690/-op-4a-05-24-hour-aortic-blood-pressure-variability-is-better-associated-with-carotid-intima-media-thickness-than-brachial-blood-pressure-variability
#16
S Yu, C Chi, Y Zhang, A A Argyris, J Blacher, M E Safar, A D Protogerou
OBJECTIVE: The purpose of this study was to investigate the association of 24-hour (24-h) brahical and aortic systolic blood pressure variabilities (BPVs) with carotid intima-media thickness (CIMT) and the differences between brachial and aortic 24-h systolic BPVs in relation to CIMT. DESIGN AND METHOD: 445 consecutive outpatients (aged 54.0 ± 13.0 years, 57.1% men) for consultation on hypertension were recruited. 24-h brachial and aortic systolic BPVs were evaluated by average real variability (ARV) and 24-h time-weighted standard deviation (wSD) using a validated 24-h ambulatory blood pressure monitor (Mobil-O-Graph NG apparatus, Germany)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27458624/-cardiovascular-risk-in-patients-with-psoriatic-arthritis
#17
REVIEW
T V Korotaeva, D S Novikoya, E Yu Loginova
Psoriatic arthritis (PsA) is a chronic.immune-mediated disease that is observed in 8-30% of psoriatic patients. It has been recently established that PsA and psoriasis are closely associated with the high prevalence of metabolic syndrome, hypertension; abdominal obesity, and a risk for cardiovascular diseases (CVD), including fatal myocardial infarction (Ml) and acute cerebrovascular accidents, which shortens lifespan in the patients compared to the general population. The authors state their belief that the synergic effect of traditional risk factors (RFs) for CYD and systemic inflammation underlie the development of atherosclerosis in PsA...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27450785/periodontitis-is-associated-with-the-risk-of-subclinical-atherosclerosis-and-peripheral-arterial-disease-in-korean-adults
#18
Yoo-Been Ahn, Myung-Seop Shin, Dong-Hun Han, Munkhzaya Sukhbaatar, Mi-Sun Kim, Hye-Sun Shin, Hyun-Duck Kim
BACKGROUND AND AIMS: We aimed to evaluate the association of periodontitis with the development of early atherosclerotic vascular disease in Korean adults. METHODS: In this cross-sectional study, a total of 1343 adults aged over 40 years were recruited from a community-based cohort of Yangpyeong county, Korea, during the period 2010-2014. Only dentate individuals were included in the study. Subclinical atherosclerosis (SA) was defined as carotid intima-media thickness (cIMT)≥0...
August 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27442639/hyperaldosteronism-and-cardiovascular-risk-in-patients-with-autosomal-dominant-polycystic-kidney-disease
#19
Silvia Lai, Luigi Petramala, Daniela Mastroluca, Emanuela Petraglia, Alessandro Di Gaeta, Elena Indino, Valeria Panebianco, Mauro Ciccariello, Hossein H Shahabadi, Alessandro Galani, Claudio Letizia, Anna Rita D'Angelo
Hypertension is commonly associated with autosomal dominant polycystic kidney disease (ADPKD), often discovered before the onset of renal failure, albeit the pathogenetic mechanisms are not well elucidated. Hyperaldosteronism in ADPKD may contribute to the development of insulin resistance and endothelial dysfunction, and progression of cardiorenal disease. The aim of study was to evaluate the prevalence of primary aldosteronism (PA) in ADPKD patients and identify some surrogate biomarkers of cardiovascular risk...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27411299/different-associations-between-blood-pressure-indices-and-carotid-artery-damages-in-a-community-based-population-of-china
#20
G Cheng, F Fan, Y Zhang, L Qi, J Jia, Y Liu, L Gao, X Han, Y Yang, Y Huo
Different blood pressure (BP) indices had varying associations with carotid intima-media thickness (cIMT) and plaques in clinical practice. However, insufficient evidence has focused on this issue, especially in Chinese population. Herein we examined associations of different BP indices with cIMT and plaques cross-sectionally in a community-based atherosclerosis cohort. We qualitatively measured cIMT and plaques, and also measured central systolic blood pressure and brachial systolic blood pressure (baSBP), from which pulse pressure (PP), and second PP (PP2) were calculated...
July 14, 2016: Journal of Human Hypertension
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