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https://www.readbyqxmd.com/read/28899593/radiographic-findings-in-patients-with-catastrophic-varus-collapse-after-total-knee-arthroplasty
#1
J Ryan Martin, Keith A Fehring, Chad D Watts, Bryan D Springer, Thomas K Fehring
BACKGROUND: Catastrophic varus collapse is an uncommon mechanism of failure in primary total knee arthroplasty (TKA). Varus collapse has been associated with obesity and smaller implant sizes. However, to our knowledge, preoperative radiographic characterization of this cohort has not been performed. Therefore, the following study evaluated preoperative alignment and how this correlates with the degree of eventual varus collapse identified in this patient population prior to revision...
August 31, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28872381/pneumatic-compression-fails-to-improve-performance-recovery-in-trained-cyclists
#2
Ryan G Overmayer, Matthew W Driller
PURPOSE: To examine the efficacy of Intermittent Sequential Pneumatic Compression (ISPC) on exercise recovery and subsequent performance, when implemented between a 20-min cycling bout (simulated scratch race) and a 4-min cycling test (simulated individual pursuit), as experienced during an Omnium track cycling competition. METHODS: Twenty-one (13 male, 8 female, mean ± SD; age: 36 ± 14 years) trained cyclists completed a familiarisation trial followed by two experimental trials in a counterbalanced, crossover design...
September 5, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28859225/widespread-brain-distribution-and-activity-following-anti-bace1-intracerebroventricular-infusion-in-nonhuman-primates
#3
Daniela Bumbaca Yadav, Janice A Maloney, Kristin R Wildsmith, Reina N Fuji, William J Meilandt, Hilda Solanoy, Yanmei Lu, Kun Peng, Blair Wilson, Pamela Chan, Kapil Gadkar, Andrew Kosky, Marisa Goo, Ann Daugherty, Jessica A Couch, Thomas Keene, Karen Hayes, Lisa Jungbauer Nikolas, Deanna Lane, Robert Switzer, Eric Adams, Ryan J Watts, Kimberly Scearce-Levie, Saileta Prabhu, Lisa Shafer, Deepak R Thakker, Keith Hildebrand, Jasvinder K Atwal
BACKGROUND AND PURPOSE: The potential for therapeutic antibody treatment of neurological diseases is limited by poor penetration across the blood-brain barrier. Intracerebroventricular (i.c.v.) delivery is a promising route to the brain, however it is unclear how efficiently i.c.v - delivered antibodies penetrate the cerebrospinal fluid (CSF)-brain barrier and distribute throughout the brain parenchyma. EXPERIMENTAL APPROACH: We evaluated the pharmacokinetics and pharmacodynamics of an inhibitory monoclonal antibody against β-site amyloid precursor protein cleaving enzyme 1 (anti-BACE1) following continuous infusion into the left lateral ventricle of healthy adult cynomolgus monkeys...
August 31, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28805660/prolyl-hydroxylase-2-inactivation-enhances-glycogen-storage-and-promotes-excessive-neutrophilic-responses
#4
Pranvera Sadiku, Joseph A Willson, Rebecca S Dickinson, Fiona Murphy, Alison J Harris, Amy Lewis, David Sammut, Ananda S Mirchandani, Eilise Ryan, Emily R Watts, A A Roger Thompson, Helen M Marriott, David H Dockrell, Cormac T Taylor, Martin Schneider, Patrick H Maxwell, Edwin R Chilvers, Massimilliano Mazzone, Veronica Moral, Chris W Pugh, Peter J Ratcliffe, Christopher J Schofield, Bart Ghesquiere, Peter Carmeliet, Moira Kb Whyte, Sarah R Walmsley
Fully activated innate immune cells are required for effective responses to infection, but their prompt deactivation and removal are essential for limiting tissue damage. Here, we have identified a critical role for the prolyl hydroxylase enzyme Phd2 in maintaining the balance between appropriate, predominantly neutrophil-mediated pathogen clearance and resolution of the innate immune response. We demonstrate that myeloid-specific loss of Phd2 resulted in an exaggerated inflammatory response to Streptococcus pneumonia, with increases in neutrophil motility, functional capacity, and survival...
August 14, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28777773/comparative-performance-of-pediatric-weight-estimation-techniques-a-human-factor-errors-analysis
#5
Susan M Abdel-Rahman, Ryan Jacobsen, Jennifer L Watts, Stacy L Doyle, Donna M OʼMalley, Tiffany D Hefner, M Denise Dowd
OBJECTIVE: We compared performance characteristics of 7 weight estimation methods examining predictive performance and human factors errors. METHODS: This was a prospective study of 80 emergency care providers (raters) and 80 children aged 2 months to 16 years. Raters estimated weights in 5 children with the following 7 strategies: visual estimation, Advanced Pediatric Life Support, Luscombe and Owens, Broselow tape, devised weight estimation method, 2D Mercy TAPE (2DT), and 3D Mercy TAPE (3DT)...
August 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28758687/root-hairs-enable-high-transpiration-rates-in-drying-soils
#6
Andrea Carminati, John B Passioura, Mohsen Zarebanadkouki, Mutez A Ahmed, Peter R Ryan, Michelle Watt, Emmanuel Delhaize
Do root hairs help roots take up water from the soil? Despite the well-documented role of root hairs in phosphate uptake, their role in water extraction is controversial. We grew barley (Hordeum vulgare cv Pallas) and its root-hairless mutant brb in a root pressure chamber, whereby the transpiration rate could be varied whilst monitoring the suction in the xylem. The method provides accurate measurements of the dynamic relationship between the transpiration rate and xylem suction. The relationship between the transpiration rate and xylem suction was linear in wet soils and did not differ between genotypes...
July 31, 2017: New Phytologist
https://www.readbyqxmd.com/read/28668474/dermal-blimp1-acts-downstream-of-epidermal-tgf%C3%AE-and-wnt-%C3%AE-catenin-to-regulate-hair-follicle-formation-and-growth
#7
Stephanie B Telerman, Emanuel Rognoni, Inês Sequeira, Angela Oliveira Pisco, Beate M Lichtenberger, Oliver Culley, Priyalakshmi Viswanathan, Ryan R Driskell, Fiona M Watt
Blimp1 is a transcriptional repressor that regulates cell growth and differentiation in multiple tissues, including skin. While in the epidermis Blimp1 is important for keratinocyte and sebocyte differentiation, its role in dermal fibroblast is unclear. Here we show that Blimp1 is dynamically regulated in dermal papilla (DP) cells during hair follicle (HF) morphogenesis and the postnatal hair cycle, preceding dermal Wnt/β-catenin activation. Blimp1 ablation in E12.5 mouse dermal fibroblasts delayed HF morphogenesis and growth and prevented new HF formation following wounding...
June 28, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28576689/coronal-alignment-predicts-the-use-of-semi-constrained-implants-in-contemporary-total-knee-arthroplasty
#8
J Ryan Martin, Keith A Fehring, Chad D Watts, Daniel L Levy, Bryan D Springer, Raymond H Kim
BACKGROUND: Semi-constrained, or varus-valgus constrained, implants are occasionally necessary to achieve stability in primary total knee arthroplasty (TKA). However, outcomes with these implants are largely unknown. Therefore, the primary goals of this study were to determine 1) can we identify preoperatively which patients might require a semi-constrained implant and 2) are there any clinical and or radiographic differences for those that require a semi-constrained implant? METHODS: A multicenter retrospective study was performed to retrospectively review patients that had a Stryker Triathlon (Kalamazoo, MI) TKA with a Total Stabilized (TS) tibial insert (n=75)...
May 30, 2017: Knee
https://www.readbyqxmd.com/read/28398999/confronting-challenges-in-monitoring-and-evaluation-innovation-in-the-context-of-the-global-plan-towards-the-elimination-of-new-hiv-infections-among-children-by-2015-and-keeping-their-mothers-alive
#9
REVIEW
Anna K Radin, Andrew A Abutu, Margaret A Okwero, Michelle R Adler, Chukwuma Anyaike, Hilda T Asiimwe, Prosper Behumbiize, Timothy A Efuntoye, Rachel L King, Linda Nabitaka Kisaakye, Dolapo T Ogundehin, Benjamin Ryan Phelps, Heather Watts, Fitti Weissglas
The Global Plan Towards the Elimination of New HIV Infections Among Children by 2015 and Keeping Their Mothers Alive (Global Plan), which was launched in 2011, set a series of ambitious targets, including a reduction of new HIV infections among children by 90% by 2015 (from a baseline year of 2009) and AIDS-related maternal mortality by 50% by 2015. To reach these targets, the Global Plan called for unprecedented investments in the prevention of mother-to-child transmission of HIV (PMTCT), innovative new approaches to service delivery, immense collective effort on the programmatic and policy fronts, and importantly, a renewed focus on data collection and use...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28390609/peri-operative-management-of-high-risk-paediatric-adenotonsillectomy-patients-a-survey-of-35-uk-tertiary-referral-centres
#10
Ryan Chin Taw Cheong, Philippe Bowles, Andrew Moore, Simon Watts
INTRODUCTION: Peri-operative management of high-risk paediatric patients undergoing adenotonsillectomy for treatment of obstructive sleep apnoea varies between tertiary referral hospitals. 'Day of surgery cancellation' (DoSC) rates of up to 11% have been reported due to pre-booked critical care being unavailable on the day of surgery as a result of competing needs from other hospital departments. We report the results of a survey of peri-operative management in UK tertiary care centres of high-risk paediatric patients undergoing adenotonsillectomy for obstructive sleep apnoea (OSA)...
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28386604/hypoxia-determines-survival-outcomes-of-bacterial-infection-through-hif-1alpha-dependent-re-programming-of-leukocyte-metabolism
#11
A A R Thompson, R S Dickinson, F Murphy, J P Thomson, H M Marriott, A Tavares, J Willson, L Williams, A Lewis, A Mirchandani, P Dos Santos Coelho, C Doherty, E Ryan, E Watts, N M Morton, S Forbes, R H Stimson, A G Hameed, N Arnold, J A Preston, A Lawrie, V Finisguerra, M Mazzone, P Sadiku, J Goveia, F Taverna, P Carmeliet, S J Foster, E R Chilvers, A S Cowburn, D H Dockrell, R S Johnson, R R Meehan, M K B Whyte, S R Walmsley
Hypoxia and bacterial infection frequently co-exist, in both acute and chronic clinical settings, and typically result in adverse clinical outcomes. To ameliorate this morbidity, we investigated the interaction between hypoxia and the host response. In the context of acute hypoxia, both S. aureus and S. pneumoniae infections rapidly induced progressive neutrophil mediated morbidity and mortality, with associated hypothermia and cardiovascular compromise. Preconditioning animals through longer exposures to hypoxia, prior to infection, prevented these pathophysiological responses and profoundly dampened the transcriptome of circulating leukocytes...
February 10, 2017: Science Immunology
https://www.readbyqxmd.com/read/28379107/gender-and-sex-trading-among-active-methamphetamine-users-in-cape-town-south-africa
#12
Ryan R Lion, Melissa H Watt, Wendee M Wechsberg, Christina S Meade
BACKGROUND: South Africa has experienced a tremendous rise in methamphetamine use since the year 2000. Sex trading is a global phenomenon that has been observed in active drug users and has been associated with risks for HIV infection and violence. OBJECTIVES: This paper describes and examines the correlates of sex trading among active methamphetamine users in Cape Town, South Africa. METHODS: Through peer referral, 360 (201 male; 159 female) active methamphetamine users were recruited in a peri-urban township...
May 12, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28281673/bace1-across-species-a-comparison-of-the-in-vivo-consequences-of-bace1-deletion-in-mice-and-rats
#13
Martin Weber, Tiffany Wu, William J Meilandt, Sara L Dominguez, Hilda O Solanoy, Janice A Maloney, Hai Ngu, Miriam Baca, Chung Kung, Lisa Lima, Timothy K Earr, Daniel Fleck, Shannon D Shields, William F Forrest, Oded Foreman, Søren Warming, Ryan J Watts, Kimberly Scearce-Levie
Assessing BACE1 (β-site APP cleaving enzyme 1) knockout mice for general health and neurological function may be useful in predicting risks associated with prolonged pharmacological BACE1 inhibition, a treatment approach currently being developed for Alzheimer's disease. To determine whether BACE1 deletion-associated effects in mice generalize to another species, we developed a novel Bace1(-/-) rat line using zinc-finger nuclease technology and compared Bace1(-/-) mice and rats with their Bace1(+/+) counterparts...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28267733/us-immigration-order-strikes-against-biotech
#14
Jeremy M Levin, Steven H Holtzman, John Maraganore, Paul J Hastings, Ron Cohen, Bassil Dahiyat, Julian Adams, Chris Adams, Brett Ahrens, Jeff Albers, Mara G Aspinall, James E Audia, Martin Babler, Peter Barrett, Zoe Barry, Nessan Bermingham, Stephen Bloch, Robert I Blum, Paul B Bolno, Michael W Bonney, Bruce Booth, Daniel M Bradbury, Steven K Brauer, Brook Byers, Pablo J Cagnoni, Brian M Cali, Isaac Ciechanover, Chip Clark, Michael D Clayman, Jeff L Cleland, Paula Cobb, Ron Cooper, Mark G Currie, John Diekman, Eric L Dobmeier, Doug Doerfler, Elizabeth Lr Donley, Deborah Dunsire, Matthew During, Jens W Eckstein, Eric Elenko, Neil A Exter, Jonathan J Fleming, Gregory J Flesher, Jean-Francois Formela, Robert Forrester, Cedric Francois, Heather Franklin, Mason W Freeman, Howard Furst, Leonard Patrick Gage, Nicholas Galakatos, Brian M Gallagher, James A Geraghty, Simba Gill, David V Goeddel, Mark A Goldsmith, Maxine Gowen, Vikas Goyal, Tom Graney, David Grayzel, Barry Greene, Paul Grint, J C Gutierrez-Ramos, Bill Haney, Tuan Ha-Ngoc, Tim Harris, Faheem Hasnain, Yujiro Steve Hata, Peter Hecht, Leslie Henshaw, Rich Heyman, Herve Hoppenot, H Robert Horvitz, Thomas E Hughes, Wende S Hutton, Stephen T Isaacs, Annalisa Jenkins, Jeff Jonker, Jeff Kaplan, Perry Karsen, Jeb Keiper, Jean Kim, Jeff Kindler, Rachel King, Vanessa King, Nina Kjellson, Scott Koenig, Gerhard Koenig, Peter Kolchinsky, Paul Laikind, Robert Bob Langer, John J Lee, Jonathan S Leff, Bruce A Leicher, Nick Leschly, Andrew Levin, Mark Levin, Arnold J Levine, Alan Levy, David R Liu, Harvey F Lodish, Uri Lopatin, Ted W Love, Guy Macdonald, Gail J Maderis, Ankit Mahadevia, Nagesh K Mahanthappa, Joel F Martin, Alex Martin, W Eddie Martucci, James G McArthur, Corey M McCann, Sean A McCarthy, C Geoffrey McDonough, John Mendlein, Larry Miller, Diego Miralles, Kenneth I Moch, Bob More, Andrew G Myers, Michael A Narachi, Amir Nashat, Wendy Nelson, William J Newell, Bernat Olle, John E Osborn, Julia C Owens, Atul Pande, Stelios Papadopoulos, H Stewart Parker, Kush M Parmar, Matthew R Patterson, Steve M Paul, Rob Perez, Matthew Perry, Cary G Pfeffer, Mike Powell, Mark Pruzanski, Dennis J Purcell, Amit Rakhit, Kartik Ramamoorthi, William Rastetter, Adrian Ad Rawcliffe, Laurence E Reid, Ron C Renaud, Jason P Rhodes, William J Rieflin, Chad Robins, Scott M Rocklage, Michael Rosenblatt, Jonathan G Rosin, William J Rutter, Saurabh Saha, Camille Samuels, Vicki L Sato, George Scangos, John A Scarlett, David Schenkein, Stuart L Schreiber, Andrew Schwab, Paul Sekhri, Rajeev Shah, Thomas Shenk, Clay B Siegall, Nick J Simon, Nancy Simonian, Jeff Stein, Michael Su, Mary T Szela, Marco Taglietti, Nina Tandon, Henri Termeer, Nancy A Thornberry, Martin Tolar, Richard Ulevitch, Akshay K Vaishnaw, Anne VanLent, Martin Varsavsky, George P Vlasuk, Michel Vounatsos, Samuel G Waksal, Neil Warma, Ryan J Watts, Yaron Werber, Christoph Westphal, Wendell Wierenga, Doug E Williams, Lewis Rusty Williams, Kleanthis G Xanthopoulos, Daphne Zohar, Sandford Sandy Zweifach
No abstract text is available yet for this article.
March 7, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28239511/reducing-disaster-exacerbated-non-communicable-diseases-through-public-health-infrastructure-resilience-perspectives-of-australian-disaster-service-providers
#15
Benjamin J Ryan, Richard C Franklin, Frederick M Burkle, Peter Aitken, Erin Smith, Kerrianne Watt, Peter Leggat
BACKGROUND: The exposure of people and infrastructure to flood and storm related disasters across the world is increasing faster than vulnerability is decreasing. For people with non-communicable diseases this presents a significant risk as traditionally the focus of disaster management systems has been on immediate trauma and communicable diseases. This focus must now be expanded to include the management of non-communicable diseases because these conditions are generating the bulk of ill health, disability and premature death around the globe...
December 21, 2016: PLoS Currents
https://www.readbyqxmd.com/read/28216087/neural-consequences-of-post-exertion-malaise-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#16
Dane B Cook, Alan R Light, Kathleen C Light, Gordon Broderick, Morgan R Shields, Ryan J Dougherty, Jacob D Meyer, Stephanie VanRiper, Aaron J Stegner, Laura D Ellingson, Suzanne D Vernon
Post exertion malaise is one of the most debilitating aspects of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, yet the neurobiological consequences are largely unexplored. The objective of the study was to determine the neural consequences of acute exercise using functional brain imaging. Fifteen female Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients and 15 healthy female controls completed 30min of submaximal exercise (70% of peak heart rate) on a cycle ergometer. Symptom assessments (e.g...
February 17, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28106546/a-common-variant-of-il-6r-is-associated-with-elevated-il-6-pathway-activity-in-alzheimer-s-disease-brains
#17
Patrick C G Haddick, Jessica L Larson, Nisha Rathore, Tushar R Bhangale, Qui T Phung, Karpagam Srinivasan, David V Hansen, Jennie R Lill, Margaret A Pericak-Vance, Jonathan Haines, Lindsay A Farrer, John S Kauwe, Gerard D Schellenberg, Carlos Cruchaga, Alison M Goate, Timothy W Behrens, Ryan J Watts, Robert R Graham, Joshua S Kaminker, Marcel van der Brug
The common p.D358A variant (rs2228145) in IL-6R is associated with risk for multiple diseases and with increased levels of soluble IL-6R in the periphery and central nervous system (CNS). Here, we show that the p.D358A allele leads to increased proteolysis of membrane bound IL-6R and demonstrate that IL-6R peptides with A358 are more susceptible to cleavage by ADAM10 and ADAM17. IL-6 responsive genes were identified in primary astrocytes and microglia and an IL-6 gene signature was increased in the CNS of late onset Alzheimer's disease subjects in an IL6R allele dependent manner...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28077575/effector-attenuating-substitutions-that-maintain-antibody-stability-and-reduce-toxicity-in-mice
#18
Megan Lo, Hok Seon Kim, Raymond K Tong, Travis W Bainbridge, Jean-Michel Vernes, Yin Zhang, Yuwen Linda Lin, Shan Chung, Mark S Dennis, Y Joy Yu Zuchero, Ryan J Watts, Jessica A Couch, Y Gloria Meng, Jasvinder K Atwal, Randall J Brezski, Christoph Spiess, James A Ernst
The antibody Fc region regulates antibody cytotoxic activities and serum half-life. In a therapeutic context, however, the cytotoxic effector function of an antibody is often not desirable and can create safety liabilities by activating native host immune defenses against cells expressing the receptor antigens. Several amino acid changes in the Fc region have been reported to silence or reduce the effector function of antibodies. These earlier studies focused primarily on the interaction of human antibodies with human Fc-γ receptors, and it remains largely unknown how such changes to Fc might translate to the context of a murine antibody...
March 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27996029/structure-of-crenezumab-complex-with-a%C3%AE-shows-loss-of-%C3%AE-hairpin
#19
Mark Ultsch, Bing Li, Till Maurer, Mary Mathieu, Oskar Adolfsson, Andreas Muhs, Andrea Pfeifer, Maria Pihlgren, Travis W Bainbridge, Mike Reichelt, James A Ernst, Charles Eigenbrot, Germaine Fuh, Jasvinder K Atwal, Ryan J Watts, Weiru Wang
Accumulation of amyloid-β (Aβ) peptides and amyloid plaque deposition in brain is postulated as a cause of Alzheimer's disease (AD). The precise pathological species of Aβ remains elusive although evidence suggests soluble oligomers may be primarily responsible for neurotoxicity. Crenezumab is a humanized anti-Aβ monoclonal IgG4 that binds multiple forms of Aβ, with higher affinity for aggregated forms, and that blocks Aβ aggregation, and promotes disaggregation. To understand the structural basis for this binding profile and activity, we determined the crystal structure of crenezumab in complex with Aβ...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27889294/increasing-the-detection-of-familial-hypercholesterolaemia-using-general-practice-electronic-databases
#20
Alistair W Vickery, Jackie Ryan, Jing Pang, Jacquie Garton-Smith, Gerald F Watts
BACKGROUND: Familial hypercholesterolaemia (FH) is a common autosomal co-dominant condition that causes premature cardiovascular disease. Awareness of FH is poor and only 10-15% of the affected population is identified. Electronic health records provide an opportunity to increase detection and awareness in general practice OBJECTIVE: To determine whether a simple electronic extraction tool can increase detection of FH in general practice. METHOD: An extraction tool applied to general practice electronic health records (EHR) to screen for FH, total cholesterol and low density lipoprotein cholesterol (LDL-c) levels in association with entered diagnostic criteria and demographic data in five general practices...
May 2017: Heart, Lung & Circulation
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