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https://www.readbyqxmd.com/read/29600961/targeting-of-nonlipidated-aggregated-apoe-with-antibodies-inhibits-amyloid-accumulation
#1
Fan Liao, Aimin Li, Monica Xiong, Nga Bien-Ly, Hong Jiang, Yin Zhang, Mary Beth Finn, Rosa Hoyle, Jennifer Keyser, Katheryn B Lefton, Grace O Robinson, Javier Remolina Serrano, Adam P Silverman, Jing L Guo, Jennifer Getz, Kirk Henne, Cheryl Eg Leyns, Gilbert Gallardo, Jason D Ulrich, Patrick M Sullivan, Eli Paul Lerner, Eloise Hudry, Zachary K Sweeney, Mark S Dennis, Bradley T Hyman, Ryan J Watts, David M Holtzman
The apolipoprotein E E4 allele of the APOE gene is the strongest genetic factor for late-onset Alzheimer disease (LOAD). There is compelling evidence that apoE influences Alzheimer disease (AD) in large part by affecting amyloid β (Aβ) aggregation and clearance; however, the molecular mechanism underlying these findings remains largely unknown. Herein, we tested whether anti-human apoE antibodies can decrease Aβ pathology in mice producing both human Aβ and apoE4, and investigated the mechanism underlying these effects...
March 30, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29512963/adrenal-insufficiency-steroid-sick-day-rules-and-the-paediatric-endocrine-nurse
#2
Taffy Makaya, Jennifer Gilbert, Fiona Ryan, Wendy Watts
Clinical governance processes are important for improving patient care. Patients with adrenal insufficiency are at significant risk if they have an adrenal crisis and require steroid therapy. Families should receive education on managing illness or stress, that is, steroid sick day rules. Most of this education is delivered by children's nurses. Two local cases of mortality related to adrenal insufficiency were reviewed and a questionnaire audit was undertaken to compare the steroid sick day rules education provided to patients and their families with published standards...
March 7, 2018: Nursing Children and Young People
https://www.readbyqxmd.com/read/29489721/post-exercise-ingestion-of-low-or-high-molecular-weight-glucose-polymer-solution-does-not-improve-cycle-performance-in-female-athletes
#3
Meredith G Mock, Katie R Hirsch, Malia N M Blue, Eric T Trexler, Erica J Roelofs, Abbie E Smith-Ryan
The current study sought to evaluate the effects of post-exercise ingestion of a high molecular weight glucose polymer solution (HMW) compared to an isocaloric low molecular weight solution (LMW) or placebo (PLA) on subsequent cycling performance in female athletes. In a randomized, double-blind, placebo-controlled, cross-over design, 10 competitive female cyclists (Mean ± SD; Age = 25.7 ± 5.0 yrs; VO2peak = 49.7 ± 4.3 ml[BULLET OPERATOR]kg[BULLET OPERATOR]min) completed three testing sessions separated by 7-10 days...
February 27, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29432615/glioma-through-the-looking-glass-molecular-evolution-of-diffuse-gliomas-and-the-glioma-longitudinal-analysis-consortium
#4
Kenneth Aldape, Samirkumar B Amin, David M Ashley, Jill S Barnholtz-Sloan, Amanda J Bates, Rameen Beroukhim, Christoph Bock, Daniel J Brat, Elizabeth B Claus, Joseph F Costello, John F de Groot, Gaetano Finocchiaro, Pim J French, Hui K Gan, Brent Griffith, Christel C Herold-Mende, Craig Horbinski, Antonio Iavarone, Steven N Kalkanis, Konstantina Karabatsou, Hoon Kim, Mathilde C M Kouwenhoven, Kerrie L McDonald, Hrvoje Miletic, Do-Hyun Nam, Ho Keung Ng, Simone P Niclou, Houtan Noushmehr, Ryan Ormond, Laila M Poisson, Guido Reifenberger, Federico Roncaroli, Jason K Sa, Peter A E Sillevis Smitt, Marion Smits, Camila F Souza, Ghazaleh Tabatabai, Erwin G Van Meir, Roel G W Verhaak, Colin Watts, Pieter Wesseling, Adelheid Woehrer, W K Alfred Yung, Christine Jungk, Ann-Christin Hau, Eric van Dyck, Bart A Westerman, Julia Yin, Olajide Abiola, Nikolaj Zeps, Sean Grimmond, Michael Buckland, Mustafa Khasraw, Erik P Sulman, Andrea M Muscat, Lucy Stead
Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas (TCGA) and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal AnalySiS Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas...
February 8, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29391249/spatial-and-single-cell-transcriptional-profiling-identifies-functionally-distinct-human-dermal-fibroblast-subpopulations
#5
Christina Philippeos, Stephanie B Telerman, Bénédicte Oulès, Angela O Pisco, Tanya J Shaw, Raul Elgueta, Giovanna Lombardi, Ryan R Driskell, Mark Soldin, Magnus D Lynch, Fiona M Watt
Previous studies have shown that mouse dermis is composed of functionally distinct fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used a combination of comparative spatial transcriptional profiling of human and mouse dermis and single-cell transcriptional profiling of human dermal fibroblasts. We show that there are at least four distinct fibroblast populations in adult human skin, not all of which are spatially segregated. We define markers permitting their isolation and show that although marker expression is lost in culture, different fibroblast subpopulations retain distinct functionality in terms of Wnt signaling, responsiveness to IFN-γ, and ability to support human epidermal reconstitution when introduced into decellularized dermis...
April 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29377378/evaluation-of-a-multimodal-direct-to-patient-educational-intervention-targeting-barriers-to-osteoporosis-care-a-randomized-clinical-trial
#6
Maria I Danila, Ryan C Outman, Elizabeth J Rahn, Amy S Mudano, David T Redden, Peng Li, Jeroan J Allison, Fred A Anderson, Allison Wyman, Susan L Greenspan, Andrea Z LaCroix, Jeri W Nieves, Stuart L Silverman, Ethel S Siris, Nelson B Watts, Michael J Miller, Jeffrey R Curtis, Amy H Warriner, Nicole C Wright, Kenneth G Saag
Osteoporosis treatment rates are declining, even among those with past fractures. Novel, low-cost approaches are needed to improve osteoporosis care. We conducted a parallel group, controlled, randomized clinical trial evaluating a behavioral intervention for improving osteoporosis medication use. A total of 2684 women with self-reported fracture history after age 45 years not using osteoporosis therapy from US Global Longitudinal Study of Osteoporosis in Women (GLOW) sites were randomized 1:1 to receive a multimodal, tailored, direct-to-patient, video intervention versus usual care...
May 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29366169/using-general-practice-electronic-databases-to-increase-the-identification-of-familial-hypercholesterolaemia-in-primary-care
#7
Jacqueline Dm Ryan, Jing Pang, Gerald F Watts, Alistair Vickery
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29363784/nutraceuticals-in-the-management-of-patients-with-statin-associated-muscle-symptoms-with-a-note-on-real-world-experience
#8
REVIEW
Natalie C Ward, Jing Pang, Jacqueline D M Ryan, Gerald F Watts
There is considerable evidence for the role of low-density lipoprotein cholesterol (LDL-C) in the development of atherosclerotic cardiovascular disease. Although statin therapy remains the most frequency prescribed medication to reduce LDL-C and lower risk of cardiovascular disease, a considerable number of patients develop muscle-related side affects. This review summarizes recent literature supporting the role of nutraceuticals as LDL-C-lowering therapy in statin-intolerant patients, with evidence from our own clinical practices...
January 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29152603/investigation-into-the-fungal-diversity-within-different-regions-of-the-gastrointestinal-tract-of-panaque-nigrolineatus-a-wood-eating-fish
#9
Caroline L Marden, Ryan McDonald, Harold J Schreier, Joy E M Watts
The Amazonian catfish, Panaque nigrolineatus have several physiological adaptions enabling the scraping and consumption of wood (xylivory), facilitating a detritivorous dietary strategy. Composed of lignocellulose, wood is a difficult substrate to degrade and as yet, it is unclear whether the fish obtains any direct nutritional benefits from wood ingestion and degradation. However, there are numerous systems that rely on microbial symbioses to provide energy and other nutritional benefits for host organisms via lignocellulose decomposition...
2017: AIMS Microbiology
https://www.readbyqxmd.com/read/28899593/radiographic-findings-in-patients-with-catastrophic-varus-collapse-after-total-knee-arthroplasty
#10
J Ryan Martin, Keith A Fehring, Chad D Watts, Bryan D Springer, Thomas K Fehring
BACKGROUND: Catastrophic varus collapse is an uncommon mechanism of failure in primary total knee arthroplasty (TKA). Varus collapse has been associated with obesity and smaller implant sizes. However, to our knowledge, preoperative radiographic characterization of this cohort has not been performed. Therefore, the following study evaluated preoperative alignment and how this correlates with the degree of eventual varus collapse identified in this patient population prior to revision...
January 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28872381/pneumatic-compression-fails-to-improve-performance-recovery-in-trained-cyclists
#11
Ryan G Overmayer, Matthew W Driller
PURPOSE: To examine the efficacy of Intermittent Sequential Pneumatic Compression (ISPC) on exercise recovery and subsequent performance, when implemented between a 20-min cycling bout (simulated scratch race) and a 4-min cycling test (simulated individual pursuit), as experienced during an Omnium track cycling competition. METHODS: Twenty-one (13 male, 8 female, mean ± SD; age: 36 ± 14 years) trained cyclists completed a familiarisation trial followed by two experimental trials in a counterbalanced, crossover design...
September 5, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28859225/widespread-brain-distribution-and-activity-following-i-c-v-infusion-of-anti-%C3%AE-secretase-bace1-in-nonhuman-primates
#12
Daniela Bumbaca Yadav, Janice A Maloney, Kristin R Wildsmith, Reina N Fuji, William J Meilandt, Hilda Solanoy, Yanmei Lu, Kun Peng, Blair Wilson, Pamela Chan, Kapil Gadkar, Andrew Kosky, Marisa Goo, Ann Daugherty, Jessica A Couch, Thomas Keene, Karen Hayes, Lisa Jungbauer Nikolas, Deanna Lane, Robert Switzer, Eric Adams, Ryan J Watts, Kimberly Scearce-Levie, Saileta Prabhu, Lisa Shafer, Deepak R Thakker, Keith Hildebrand, Jasvinder K Atwal
BACKGROUND AND PURPOSE: The potential for therapeutic antibody treatment of neurological diseases is limited by poor penetration across the blood-brain barrier. I.c.v. delivery is a promising route to the brain; however, it is unclear how efficiently antibodies delivered i.c.v. penetrate the cerebrospinal spinal fluid (CSF)-brain barrier and distribute throughout the brain parenchyma. EXPERIMENTAL APPROACH: We evaluated the pharmacokinetics and pharmacodynamics of an inhibitory monoclonal antibody against β-secretase 1 (anti-BACE1) following continuous infusion into the left lateral ventricle of healthy adult cynomolgus monkeys...
November 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28805660/prolyl-hydroxylase-2-inactivation-enhances-glycogen-storage-and-promotes-excessive-neutrophilic-responses
#13
Pranvera Sadiku, Joseph A Willson, Rebecca S Dickinson, Fiona Murphy, Alison J Harris, Amy Lewis, David Sammut, Ananda S Mirchandani, Eilise Ryan, Emily R Watts, A A Roger Thompson, Helen M Marriott, David H Dockrell, Cormac T Taylor, Martin Schneider, Patrick H Maxwell, Edwin R Chilvers, Massimilliano Mazzone, Veronica Moral, Chris W Pugh, Peter J Ratcliffe, Christopher J Schofield, Bart Ghesquiere, Peter Carmeliet, Moira Kb Whyte, Sarah R Walmsley
Fully activated innate immune cells are required for effective responses to infection, but their prompt deactivation and removal are essential for limiting tissue damage. Here, we have identified a critical role for the prolyl hydroxylase enzyme Phd2 in maintaining the balance between appropriate, predominantly neutrophil-mediated pathogen clearance and resolution of the innate immune response. We demonstrate that myeloid-specific loss of Phd2 resulted in an exaggerated inflammatory response to Streptococcus pneumonia, with increases in neutrophil motility, functional capacity, and survival...
September 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28777773/comparative-performance-of-pediatric-weight-estimation-techniques-a-human-factor-errors-analysis
#14
Susan M Abdel-Rahman, Ryan Jacobsen, Jennifer L Watts, Stacy L Doyle, Donna M OʼMalley, Tiffany D Hefner, M Denise Dowd
OBJECTIVE: We compared performance characteristics of 7 weight estimation methods examining predictive performance and human factors errors. METHODS: This was a prospective study of 80 emergency care providers (raters) and 80 children aged 2 months to 16 years. Raters estimated weights in 5 children with the following 7 strategies: visual estimation, Advanced Pediatric Life Support, Luscombe and Owens, Broselow tape, devised weight estimation method, 2D Mercy TAPE (2DT), and 3D Mercy TAPE (3DT)...
August 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28758687/root-hairs-enable-high-transpiration-rates-in-drying-soils
#15
Andrea Carminati, John B Passioura, Mohsen Zarebanadkouki, Mutez A Ahmed, Peter R Ryan, Michelle Watt, Emmanuel Delhaize
Do root hairs help roots take up water from the soil? Despite the well-documented role of root hairs in phosphate uptake, their role in water extraction is controversial. We grew barley (Hordeum vulgare cv Pallas) and its root-hairless mutant brb in a root pressure chamber, whereby the transpiration rate could be varied whilst monitoring the suction in the xylem. The method provides accurate measurements of the dynamic relationship between the transpiration rate and xylem suction. The relationship between the transpiration rate and xylem suction was linear in wet soils and did not differ between genotypes...
July 31, 2017: New Phytologist
https://www.readbyqxmd.com/read/28668474/dermal-blimp1-acts-downstream-of-epidermal-tgf%C3%AE-and-wnt-%C3%AE-catenin-to%C3%A2-regulate-hair-follicle-formation-and%C3%A2-growth
#16
Stephanie B Telerman, Emanuel Rognoni, Inês Sequeira, Angela Oliveira Pisco, Beate M Lichtenberger, Oliver J Culley, Priyalakshmi Viswanathan, Ryan R Driskell, Fiona M Watt
B-lymphocyte-induced maturation protein 1 (Blimp1) is a transcriptional repressor that regulates cell growth and differentiation in multiple tissues, including skin. Although in the epidermis Blimp1 is important for keratinocyte and sebocyte differentiation, its role in dermal fibroblasts is unclear. Here we show that Blimp1 is dynamically regulated in dermal papilla cells during hair follicle (HF) morphogenesis and the postnatal hair cycle, preceding dermal Wnt/β-catenin activation. Blimp1 ablation in E12...
November 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28576689/coronal-alignment-predicts-the-use-of-semi-constrained-implants-in-contemporary-total-knee-arthroplasty
#17
J Ryan Martin, Keith A Fehring, Chad D Watts, Daniel L Levy, Bryan D Springer, Raymond H Kim
BACKGROUND: Semi-constrained, or varus-valgus constrained, implants are occasionally necessary to achieve stability in primary total knee arthroplasty (TKA). However, outcomes with these implants are largely unknown. Therefore, the primary goals of this study were to determine 1) can we identify preoperatively which patients might require a semi-constrained implant and 2) are there any clinical and or radiographic differences for those that require a semi-constrained implant? METHODS: A multicenter retrospective study was performed to retrospectively review patients that had a Stryker Triathlon (Kalamazoo, MI) TKA with a Total Stabilized (TS) tibial insert (n=75)...
May 30, 2017: Knee
https://www.readbyqxmd.com/read/28398999/confronting-challenges-in-monitoring-and-evaluation-innovation-in-the-context-of-the-global-plan-towards-the-elimination-of-new-hiv-infections-among-children-by-2015-and-keeping-their-mothers-alive
#18
REVIEW
Anna K Radin, Andrew A Abutu, Margaret A Okwero, Michelle R Adler, Chukwuma Anyaike, Hilda T Asiimwe, Prosper Behumbiize, Timothy A Efuntoye, Rachel L King, Linda Nabitaka Kisaakye, Dolapo T Ogundehin, Benjamin Ryan Phelps, Heather Watts, Fitti Weissglas
The Global Plan Towards the Elimination of New HIV Infections Among Children by 2015 and Keeping Their Mothers Alive (Global Plan), which was launched in 2011, set a series of ambitious targets, including a reduction of new HIV infections among children by 90% by 2015 (from a baseline year of 2009) and AIDS-related maternal mortality by 50% by 2015. To reach these targets, the Global Plan called for unprecedented investments in the prevention of mother-to-child transmission of HIV (PMTCT), innovative new approaches to service delivery, immense collective effort on the programmatic and policy fronts, and importantly, a renewed focus on data collection and use...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28390609/peri-operative-management-of-high-risk-paediatric-adenotonsillectomy-patients-a-survey-of-35-uk-tertiary-referral-centres
#19
Ryan Chin Taw Cheong, Philippe Bowles, Andrew Moore, Simon Watts
INTRODUCTION: Peri-operative management of high-risk paediatric patients undergoing adenotonsillectomy for treatment of obstructive sleep apnoea varies between tertiary referral hospitals. 'Day of surgery cancellation' (DoSC) rates of up to 11% have been reported due to pre-booked critical care being unavailable on the day of surgery as a result of competing needs from other hospital departments. We report the results of a survey of peri-operative management in UK tertiary care centres of high-risk paediatric patients undergoing adenotonsillectomy for obstructive sleep apnoea (OSA)...
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28386604/hypoxia-determines-survival-outcomes-of-bacterial-infection-through-hif-1alpha-dependent-re-programming-of-leukocyte-metabolism
#20
A A R Thompson, R S Dickinson, F Murphy, J P Thomson, H M Marriott, A Tavares, J Willson, L Williams, A Lewis, A Mirchandani, P Dos Santos Coelho, C Doherty, E Ryan, E Watts, N M Morton, S Forbes, R H Stimson, A G Hameed, N Arnold, J A Preston, A Lawrie, V Finisguerra, M Mazzone, P Sadiku, J Goveia, F Taverna, P Carmeliet, S J Foster, E R Chilvers, A S Cowburn, D H Dockrell, R S Johnson, R R Meehan, M K B Whyte, S R Walmsley
Hypoxia and bacterial infection frequently co-exist, in both acute and chronic clinical settings, and typically result in adverse clinical outcomes. To ameliorate this morbidity, we investigated the interaction between hypoxia and the host response. In the context of acute hypoxia, both S. aureus and S. pneumoniae infections rapidly induced progressive neutrophil mediated morbidity and mortality, with associated hypothermia and cardiovascular compromise. Preconditioning animals through longer exposures to hypoxia, prior to infection, prevented these pathophysiological responses and profoundly dampened the transcriptome of circulating leukocytes...
February 10, 2017: Science Immunology
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