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https://www.readbyqxmd.com/read/29452253/remote-limb-ischemic-postconditioning-protects-against-cerebral-ischemia-reperfusion-injury-by-activating-ampk-dependent-autophagy
#1
Hao Guo, Lei Zhao, Bodong Wang, Xia Li, Hao Bai, Haixiao Liu, Liang Yue, Wei Guo, Zhenyuan Bian, Li Gao, Dayun Feng, Yan Qu
Remote limb ischemic postconditioning (RIPoC) is a promising adjunct treatment for cerebral ischemia-reperfusion (IR) injury. However, the underlying mechanisms have not been fully elucidated yet. The present study aims to investigate potential involvement and regulatory mechanisms of autophagy in RIPoC treatment against cerebral IR injury in mice. Mice were subjected to 2 h middle cerebral artery occlusion (MCAO) then treated with vehicle, 3-methyladenine (3-MA, an autophagy inhibitor), or compound C (an AMPK inhibitor) at the onset of reperfusion...
February 13, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29451906/brain-changes-due-to-hypoxia-during-light-anaesthesia-can-be-prevented-by-deepening-anaesthesia-a-study-in-rats
#2
Setayesh R Tasbihgou, Mina Netkova, Alain F Kalmar, Janine Doorduin, Michel M R F Struys, Regien G Schoemaker, Anthony R Absalom
In anaesthetic practice the risk of cerebral ischemic/hypoxic damage is thought to be attenuated by deep anaesthesia. The rationale is that deeper anaesthesia reduces cerebral oxygen demand more than light anaesthesia, thereby increasing the tolerance to ischemia or hypoxia. However, evidence to support this is scarce. We thus investigated the influence of light versus deep anaesthesia on the responses of rat brains to a period of hypoxia. In the first experiment we exposed adult male Wistar rats to deep or light propofol anaesthesia and then performed [18F]- Fludeoxyglucose (FDG) Positron Emission Tomography (PET) scans to verify the extent of cerebral metabolic suppression...
2018: PloS One
https://www.readbyqxmd.com/read/29451327/microrna-365-modulates-astrocyte-conversion-into-neuron-in-adult-rat-brain-after-stroke-by-targeting-pax6
#3
Jia-Lin Mo, Qi Liu, Zeng-Wei Kou, Kun-Wei Wu, Ping Yang, Xian-Hua Chen, Feng-Yan Sun
Reactive astrocytes induced by ischemia can transdifferentiate into mature neurons. This neurogenic potential of astrocytes may have therapeutic value for brain injury. Epigenetic modifications are widely known to involve in developmental and adult neurogenesis. PAX6, a neurogenic fate determinant, contributes to the astrocyte-to-neuron conversion. However, it is unclear whether microRNAs (miRs) modulate PAX6-mediated astrocyte-to-neuron conversion. In the present study we used bioinformatic approaches to predict miRs potentially targeting Pax6, and transient middle cerebral artery occlusion (MCAO) to model cerebral ischemic injury in adult rats...
February 16, 2018: Glia
https://www.readbyqxmd.com/read/29451211/electroacupuncture-preconditioning-protects-against-focal-cerebral-ischemia-reperfusion-injury-via-suppression-of-dynamin-related-protein-1
#4
Gao-Feng Zhang, Pei Yang, Zeng Yin, Huai-Long Chen, Fu-Guo Ma, Bin Wang, Li-Xin Sun, Yan-Lin Bi, Fei Shi, Ming-Shan Wang
Electroacupuncture preconditioning at acupoint Baihui (GV20) can reduce focal cerebral ischemia/reperfusion injury. However, the precise protective mechanism remains unknown. Mitochondrial fission mediated by dynamin-related protein 1 (Drp1) can trigger neuronal apoptosis following cerebral ischemia/reperfusion injury. Herein, we examined the hypothesis that electroacupuncture pretreatment can regulate Drp1, and thus inhibit mitochondrial fission to provide cerebral protection. Rat models of focal cerebral ischemia/reperfusion injury were established by middle cerebral artery occlusion at 24 hours after 5 consecutive days of preconditioning with electroacupuncture at GV20 (depth 2 mm, intensity 1 mA, frequency 2/15 Hz, for 30 minutes, once a day)...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29451209/predictors-of-short-term-outcome-in-patients-with-acute-middle-cerebral-artery-occlusion-unsuitability-of-fluid-attenuated-inversion-recovery-vascular-hyperintensity-scores
#5
Chan-Chan Li, Xiao-Zhu Hao, Jia-Qi Tian, Zhen-Wei Yao, Xiao-Yuan Feng, Yan-Mei Yang
Fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) is used to assess leptomeningeal collateral circulation, but clinical outcomes of patients with FVH can be very different. The aim of the present study was to assess a FVH score and explore its relationship with clinical outcomes. Patients with acute ischemic stroke due to middle cerebral artery M1 occlusion underwent magnetic resonance imaging and were followed up at 10 days (National Institutes of Health Stroke Scale) and 90 days (modified Rankin Scale) to determine short-term clinical outcomes...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29450625/mechanical-thrombectomy-in-patients-with-acute-ischemic-stroke-on-anticoagulation-therapy
#6
David Černík, Daniel Šaňák, Petra Divišová, Martin Köcher, Filip Cihlář, Jana Zapletalová, Tomáš Veverka, Andrea Prcúchová, Dušan Ospalík, Marie Černá, Petra Janoušová, Michal Král, Tomáš Dorňák, Vojtěch Prášil, David Franc, Petr Kaňovský
INTRODUCTION/PURPOSE: Mechanical thrombectomy (MT) for acute ischemic stroke (IS) can be performed also in patients on anticoagulation therapy (AT); however, sufficient and reliable data about safety and efficacy of MT are still missing. Thus, we aimed to compare these parameters between patients treated on AT and without AT. MATERIALS AND METHODS: All consecutive IS patients treated with MT using stent retrievers were included in the retrospective analysis. Neurological deficit was scored using National Institutes of Health Stroke Scale (NIHSS) and 90-day clinical outcome using modified Rankin scale with a score 0-2 for good outcome...
February 15, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29449542/long-non-coding-rnas-in-ischemic-stroke
#7
REVIEW
Mei-Hua Bao, Vivian Szeto, Burton B Yang, Shu-Zhen Zhu, Hong-Shuo Sun, Zhong-Ping Feng
Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke patients or ischemia insulted animals using new technologies such as RNA-seq, deep sequencing, and microarrays. Nine specific lncRNAs, antisense non-coding RNA in the INK4 locus (ANRIL), metastasis-associate lung adenocarcinoma transcript 1 (MALAT1), N1LR, maternally expressed gene 3 (MEG3), H19, CaMK2D-associated transcript 1 (C2dat1), Fos downstream transcript (FosDT), small nucleolar RNA host gene 14 (SNHG14), and taurine-upregulated gene 1 (TUG1), were found increased in cerebral ischemic animals and/or oxygen-glucose deprived (OGD) cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29449517/-a-case-of-moyamoya-disease-with-postoperative-cerebral-hyperperfusion-syndrome-followed-by-cerebral-infarction-due-to-watershed-shift
#8
Kimitoshi Sato, Shun Tsudaka, Takanori Miki, Norikata Kobayashi, Taro Yamashita, Kiyoharu Imataka, Takashi Yoshida, Fuminori Shimizu
The concept of "watershed shift"(WS)has been proposed as a cause of the ischemic complications following a superficial temporal artery-middle cerebral artery(STA-MCA)bypass operation performed for the management of moyamoya disease. Previous reports have observed that only 1.2-5.7% of the patients who underwent a bypass operation for the management of moyamoya disease developed cerebral infarction secondary to the WS phenomenon. To date, the WS phenomenon has not been objectively proven on imaging studies...
February 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29448967/facial-nerve-stimulation-in-normal-pigs-and-healthy-human-volunteers-transitional-development-of-a-medical-device-for-the-emergency-treatment-of-ischemic-stroke
#9
Olivia Sanchez, Andrea García, Fernando Castro-Prado, Miriam Perez, Rafael Lara-Estrada, Martin Ramirez-Meza, Montserrat Godinez, Michael L Coco, Joaquín Azpiroz, Mark K Borsody, Emilio Sacristán
BACKGROUND: Magnetic stimulation of the facial nerve has been tested in preclinical studies as a new, non-invasive emergency treatment of ischemic stroke that acts by increasing cerebral blood flow (CBF). The objective of the studies reported herein was to identify minimal stimulation parameters that increase CBF in large animals and then test those stimulation parameters in healthy volunteers for safety, tolerability, and effectiveness at increasing CBF. This translational research is necessary preparation for clinical studies in ischemic stroke patients...
February 15, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29447771/topographical-distribution-of-perioperative-cerebral-infarction-associated-with-transcatheter-aortic-valve-implantation
#10
Jonathon P Fanning, Allan J Wesley, Darren L Walters, Andrew A Wong, Adrian G Barnett, Wendy E Strugnell, David G Platts, John F Fraser
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is associated with a high incidence of cerebrovascular injury. As these injuries are thought to be primarily embolic, neuroprotection strategies have focused on embolic protection devices. However, the topographical distribution of cerebral emboli and how this impacts on the effectiveness of these devices have not been thoroughly assessed. Here, we evaluated the anatomical characteristics of magnetic resonance imaging (MRI)-defined cerebral ischemic lesions occurring secondary to TAVI to enhance our understanding of the distribution of cardioembolic phenomena...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29447348/transcriptome-analysis-reveals-intermittent-fasting-induced-genetic-changes-in-ischemic-stroke
#11
Joonki Kim, Sung-Wook Kang, Karthik Mallilankaraman, Sang-Ha Baik, James C Lim, Priyanka Balaganapathy, David T She, Ker-Zhing Lok, David Y Fann, Uma Thambiayah, Sung-Chun Tang, Alexis M Stranahan, S Thameem Dheen, Mathias Gelderblom, Raymond C Seet, Vardan T Karamyan, Raghu Vemuganti, Christopher G Sobey, Mark P Mattson, Dong-Gyu Jo, Thiruma V Arumugam
Genetic changes due to dietary intervention in the form of either calorie restriction (CR) or intermittent fasting (IF) are not reported in detail until now. However, it is well established that both CR and IF extend the lifespan and protect against neurodegenerative diseases and stroke. The current research aims were first to describe the transcriptomic changes in brains of IF mice and, second, to determine whether IF induces extensive transcriptomic changes following ischemic stroke to protect the brain from injury...
February 13, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29446510/use-of-t-1-relaxation-time-in-rotating-frame-t-1-%C3%AF-and-apparent-diffusion-coefficient-to-estimate-cerebral-stroke-evolution
#12
Yuefa Tan, Jun Xu, Ruiying Chen, Bin Chen, Juan Xu, Daokun Ren, Queenie Chan, Yingjie Mei, Yuankui Wu, Yikai Xu
BACKGROUND: The major factor for the appropriate treatment strategies for ischemia patients is its onset timing. PURPOSE/HYPOTHESIS: To study to evaluate the diagnostic accuracy of T 1 relaxation time in a rotating frame (T 1 ρ) and apparent diffusion coefficient (ADC) from MRI to estimate ischemia stages. STUDY TYPE: Prospective. POPULATION/SUBJECTS/PHANTOM/SPECIMEN/ANIMAL MODEL: In all, 73 patients (49 males, aged 29-78 years and 24 females, aged 22-94 years) with ischemia were prospectively imaged with T 1 ρ and diffusion MRI during the postischemic period...
February 15, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29445441/potential-new-cysteine-sparing-mutation-in-the-notch3-gene-in-a-patient-with-nonfamilial-cadasil-like-disease
#13
Adnan I Qureshi, Muhammad T Khan, Omer Naveed, Muhammad A Saleem
Background: Several different mutations have been reported in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We present a unique case with transversion not involving cysteine on neurogenic locus notch homolog protein 3 gene. Case description: We present a case of 65-year-old woman with new ischemic stroke resulting in right hemiparesis. She has previously suffered minor strokes at age 56, 58, and 60 years and migraine headaches between age 10 and 50 years...
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29445434/primary-endovascular-treatment-of-acute-ischemic-stroke-using-stent-retrievers-initial-egyptian-experience
#14
Ossama Yassin Mansour, Abdulrahman Mostafa Ibrahim Ali, Mohamed Megahed
Background: Several mechanical thrombectomy (MT) devices have been designed with the goal of improving the recanalization rates of major intracranial artery occlusions. Objective: In this single-center experience, we analyzed the acute ischemic stroke (AIS) treatment with Primary MT; safety and efficacy and clinical results in our patients with large vessel occlusion (LVO). Methods: During a five-year period (from September 2011 to July 2016), out of 996 patients who presented to our center with a diagnosis of AIS, 113 (11...
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29443076/optimized-management-of-endovascular-treatment-for-acute-ischemic-stroke
#15
Katharina Schregel, Daniel Behme, Ioannis Tsogkas, Michael Knauth, Ilko Maier, André Karch, Rafael Mikolajczyk, Mathias Bähr, Jörn Schäper, José Hinz, Jan Liman, Marios-Nikos Psychogios
This manuscript describes a streamlined protocol for the management of patients with acute ischemic stroke, which aims at the minimization of time from hospital admission to reperfusion. Rapid restoration of cerebral blood flow is essential for the outcomes of patients with acute ischemic stroke. Endovascular treatment (EVT) has become the standard of care to accomplish this in patients with acute stroke due to large vessel occlusion (LVO). To achieve reperfusion of ischemic brain regions as fast as possible, all in-hospital time delays have to be carefully avoided...
January 18, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29441954/synthesis-and-biological-evaluation-of-novel-4-5-bisindolyl-1-2-4-triazol-3-ones-as-glycogen-synthase-kinase-3%C3%AE-inhibitors-and-neuroprotective-agents
#16
Yuanyuan Hu, Wenchen Ruan, Anhui Gao, Yubo Zhou, Lixin Gao, Meng Xu, Jianrong Gao, Qing Ye, Jia Li, Tao Pang
A series of novel 4,5-bisindolyl-1,2,4-triazol-3-ones were designed, prepared and evaluated for their glycogen synthase kinase (GSK)-3β inhibitory activities. Compounds exhibited favorable inhibitory potency towards GSK-3β kinase at the molecular level and in cells indicated by significantly reducing GSK-3β substrate Tau phosphorylation at Ser396 in primary neurons showing the inhibition of cellular GSK-3β. In an in vitro model of neuronal injury, compounds 6b, 6d and 6f prevented glutamate-induced neuronal death which was closely associated with cerebral ischemic stroke...
December 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440474/neuroprotective-effects-of-magl-monoacylglycerol-lipase-inhibitors-in-experimental-ischemic-stroke
#17
Sang-Ho Choi, Allison L Arai, Yongshan Mou, Byeongteck Kang, Cecil Chern-Chyi Yen, John Hallenbeck, Afonso C Silva
BACKGROUND AND PURPOSE: MAGL (monoacylglycerol lipase) is an enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol and regulates the production of arachidonic acid and prostaglandins-substances that mediate tissue inflammatory response. Here, we have studied the effects of the selective MAGL inhibitors JZL184 and MJN110 and their underlying molecular mechanisms on 3 different experimental models of focal cerebral ischemia. METHODS: SHR (spontaneously hypertensive rats) and normotensive WKY (Wistar Kyoto) rats were subject to an intracortical injection of the potent vasoconstrictor endothelin-1, permanent occlusion of a distal segment of the middle cerebral artery via craniectomy, or transient occlusion of the middle cerebral artery by the intraluminal suture method...
February 13, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29440356/arterial-diameter-and-the-gender-disparity-in-stroke-thrombectomy-outcomes
#18
Mark A Davison, Bichun Ouyang, Kavantissa M Keppetipola, Michael Chen
BACKGROUND: Compared with males, females consistently fare worse following mechanical thrombectomy for large vessel ischemic strokes. Understanding why this gender disparity occurs may guide improvements in future treatment strategies. In this study, we aim to determine whether gender differences in cerebral arterial diameter correlate with clinical outcomes following stroke thrombectomy. METHODS: We performed an observational study of consecutive acute ischemic stroke patients undergoing mechanical thrombectomy at a single, urban tertiary care medical center...
February 12, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29440008/novel-%C3%AE-actin-gene-mutation-p-ala21val-causing-familial-hypertrophic-cardiomyopathy-myocardial-noncompaction-and-transmural-crypts-clinical-pathologic-correlation
#19
Andrea Frustaci, Alessandro De Luca, Valentina Guida, Tommaso Biagini, Tommaso Mazza, Carlo Gaudio, Claudio Letizia, Matteo Antonio Russo, Nicola Galea, Cristina Chimenti
BACKGROUND: Mutations of α-actin gene (ACTC1) have been phenotypically related to various cardiac anomalies, including hypertrophic cardiomyopathy and dilated cardiomyopathy and left ventricular (LV) myocardial noncompaction. A novel ACTC mutation is reported as cosegregating for familial hypertrophic cardiomyopathy and LV myocardial noncompaction with transmural crypts. METHODS AND RESULTS: In an Italian family of 7 subjects, 4 aged 10 (II-1), 14 (II-2), 43 (I-4) and 46 years (I-5), presenting abnormal ECG changes, dyspnea and palpitation (II-2, I-4, and I-5), and recurrent cerebral ischemic attack (I-5), underwent 2-dimensional echo, cardiac magnetic resonance, Holter monitoring, and next-generation sequencing gene analysis...
February 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29439730/resolvin-d2-protects-against-cerebral-ischemia-reperfusion-injury-in-rats
#20
Gang Zuo, Dongping Zhang, Rutao Mu, Haitao Shen, Xiang Li, Zhong Wang, Haiying Li, Gang Chen
Cerebral ischemia/reperfusion (I/R) injury is a critical factor leading to a poor prognosis for ischemic stroke patients. ω-3 fatty acid supplements taken as part of a daily diet have been shown to improve the prognosis of patients with ischemic stroke. In this study, we aimed to investigate the potential effects of resolvin D2 (RvD2), a derivative of ω-3 fatty acids, and its possible advantage on cerebral I/R injury in rats. Cerebral I/R caused by middle cerebral artery occlusion and reperfusion (MCAO/R) was established in Sprague-Dawley rats...
February 13, 2018: Molecular Brain
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