keyword
MENU ▼
Read by QxMD icon Read
search

cerebral ischemic

keyword
https://www.readbyqxmd.com/read/29029200/lateral-cerebellar-nucleus-stimulation-has-selective-effects-on-glutamatergic-and-gabaergic-perilesional-neurogenesis-after-cortical-ischemia-in-the-rodent-model
#1
Hugh H Chan, Jessica Cooperrider, Zhihong Chen, John T Gale, Kenneth B Baker, Connor A Wathen, Claire R Modic, Hyun-Joo Park, Andre G Machado
BACKGROUND: Chronic deep brain stimulation of the rodent lateral cerebellar nucleus (LCN) has been demonstrated to enhance motor recovery following cortical ischemia. This effect is concurrent with synaptogenesis and expression of long-term potentiation markers in the perilesional cerebral cortex. OBJECTIVE: To further investigate the cellular changes associated with chronic LCN stimulation in the ischemic rodent by examining neurogenesis along the cerebellothalamocortical pathway...
September 27, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29026617/cerebral-vasculitis-and-intracranial-multiple-aneurysms-in-a-child-with-lyme-neuroborreliosis
#2
Elisa Kortela, Jukka Hytönen, Jussi Numminen, Margit Overmyer, Harri Saxen, Jarmo Oksi
Introduction. Lyme borreliosis is a multisystem tick-borne disease caused by Borrelia burgdorferi. Neurological manifestations are reported in up to 15 % of adult patients with Lyme disease, while the frequency among children is higher. The most common manifestations are painful radiculopathy, facial nerve paresis and lymphocytic meningitis. Epileptic seizures and cerebral vasculitis with stroke or aneurysms are very rare complications. Case presentation. We describe a paediatric patient with sensorineural auditory dysfunction, headache, fatigue and epileptic seizures as sequelae of meningoencephalitis/Lyme neuroborreliosis (LNB) caused by B...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29025728/necessary-catheter-diameters-for-mechanical-thrombectomy-with-adapt
#3
O Nikoubashman, A Nikoubashman, M Büsen, M Wiesmann
BACKGROUND AND PURPOSE: Large-bore catheters allow mechanical thrombectomy in ischemic stroke by engaging and retrieving clots without additional devices (direct aspiration first-pass technique [ADAPT]). The purpose of this study was to establish a model for minimal catheter diameters needed for ADAPT. MATERIALS AND METHODS: We established a theoretic model for the calculation of minimal catheter diameters needed for ADAPT. We then verified its validity in 28 ADAPT maneuvers in a porcine in vivo model...
October 12, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29023958/stroke-induced-chronic-systolic-dysfunction-driven-by-sympathetic-overactivity
#4
Michael Bieber, Rudolf A Werner, Edit Tanai, Ulrich Hofmann, Takahiro Higuchi, Kai Schuh, Peter U Heuschmann, Stefan Frantz, Oliver Ritter, Peter Kraft, Christoph Kleinschnitz
OBJECTIVE: Cardiac diseases are established risk factors for ischemic stroke incidence and severity. Conversely, there is increasing evidence that brain ischemia can cause cardiac dysfunction. The mechanisms underlying this neurogenic heart disease are incompletely understood. While it is established that ischemic stroke is associated with cardiac arrhythmias, myocardial damage, elevated cardiac enzymes and plasma catecholamines in the acute phase, nothing is known about the delayed consequences of ischemic stroke on cardiovascular function...
October 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29022576/xueshuantong-injection-lyophilized-combined-with-salvianolate-lyophilized-injection-protects-against-focal-cerebral-ischemia-reperfusion-injury-in-rats-through-attenuation-of-oxidative-stress
#5
Fu-Jiang Wang, Shao-Xia Wang, Li-Juan Chai, Yue Zhang, Hong Guo, Li-Min Hu
Salvianolate lyophilized injection (SLI) and Xueshuantong injection (lyophilized) (XST) are two herbal standardized preparations that have been widely used in China for the treatment of acute cerebral infarction. In this study, we investigated the neuroprotective effects of SLI combined with XST in a rat model of middle cerebral artery occlusion-reperfusion (MCAO/R). Wistar rats were subjected to 1.5 h of MCAO followed by reperfusion for 3 h, then were treated with SLI or XST alone, or with their combinations via tail vein injection daily for 3 d...
October 12, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29021986/integrated-treatment-modality-of-cathodal-transcranial-direct-current-stimulation-with-peripheral-sensory-stimulation-affords-neuroprotection-in-a-rat-stroke-model
#6
Yu-Hang Liu, Su Jing Chan, Han-Chi Pan, Aishwarya Bandla, Nicolas K K King, Peter Tsun Hon Wong, You-Yin Chen, Wai Hoe Ng, Nitish V Thakor, Lun-De Liao
Cathodal-transcranial direct current stimulation induces therapeutic effects in animal ischemia models by preventing the expansion of ischemic injury during the hyperacute phase of ischemia. However, its efficacy is limited by an accompanying decrease in cerebral blood flow. On the other hand, peripheral sensory stimulation can increase blood flow to specific brain areas resulting in rescue of neurovascular functions from ischemic damage. Therefore, the two modalities appear to complement each other to form an integrated treatment modality...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/29021311/acute-ischemic-stroke-with-tandem-lesions-technical-endovascular-management-and-clinical-outcomes-from-the-escape-trial
#7
Zarina Assis, Bijoy K Menon, Mayank Goyal, Andrew M Demchuk, Jai Shankar, Jeremy L Rempel, Daniel Roy, Alexander Y Poppe, Victor Yang, Cheemun Lum, Dar Dowlatshahi, John Thornton, Hana Choe, Paul A Burns, Donald F Frei, Blaise W Baxter, Michael D Hill
BACKGROUND: Tandem occlusions of the extracranial carotid and intracranial carotid or middle cerebral artery have a particularly poor prognosis without treatment. Several management strategies have been used with no clear consensus recommendations. We examined subjects with tandem occlusions enrolled in the ESCAPE trial and their outcomes. METHODS: Data are from the ESCAPE trial. Additional data were sought on interventions for each subject. RESULTS: There were 54 (17%) subjects with tandem extracranial and intracranial occlusions...
October 11, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29019942/nadph-oxidase-related-pathophysiology-in-experimental-models-of-stroke
#8
REVIEW
Hiroshi Yao, Tetsuro Ago, Takanari Kitazono, Toru Nabika
Several experimental studies have indicated that nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) exert detrimental effects on ischemic brain tissue; Nox-knockout mice generally exhibit resistance to damage due to experimental stroke following middle cerebral artery occlusion (MCAO). Furthermore, our previous MCAO study indicated that infarct size and blood-brain barrier breakdown are enhanced in mice with pericyte-specific overexpression of Nox4, relative to levels observed in controls. However, it remains unclear whether Nox affects the stroke outcome directly by increasing oxidative stress at the site of ischemia, or indirectly by modifying physiological variables such as blood pressure or cerebral blood flow (CBF)...
October 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29018652/anastomotic-aneurysm-formation-after-high-flow-bypass-surgery-a-case-report-with-histopathological-study
#9
Tatsuya Uchida, Masanori Yoshino, Shinji Ito, Takayuki Hara
Bypass surgery is often used in the treatment of large and giant aneurysms. Major complications that often arise during the perioperative period include cranial nerve palsy, ischemic complications, and hyperperfusion. However, there have been a few reports about late onset complications such as anastomotic aneurysms. In particular, anastomotic aneurysm after high flow bypasses has never been reported. A 57-year-old woman who had been suffering from left eye pain was diagnosed with a large aneurysm of the left internal carotid artery (ICA) in the cavernous portion...
October 2017: NMC Case Rep J
https://www.readbyqxmd.com/read/29018649/rapid-recanalization-using-trevoprovue-through-a-4-2-fr-catheter-without-a-guiding-catheter-via-transbrachial-approach-a-case-report
#10
Susumu Yamaguchi, Nobutaka Horie, Yoichi Morofuji, Kei Satoh, Kazuhiko Suyama
Mechanical thrombectomy with a stent retriever has been reported to achieve high rates of successful recanalization, and reduce disability and mortality in patients with acute ischemic stroke (AIS) due to proximal vessel occlusion. However, in a few cases, the treatment is difficult due to artery tortuosity or other factors. The authors present a case of a 94-year-old man presenting with acute right middle cerebral artery occlusion. We attempted to treat using a stent retriever via transfemoral approach, but failed to advance the guiding catheter into the right internal carotid artery due to femoral artery tortuosity and a type III arch...
October 2017: NMC Case Rep J
https://www.readbyqxmd.com/read/29018327/maternal-cigarette-smoke-exposure-worsens-neurological-outcomes-in-adolescent-offspring-with-hypoxic-ischemic-injury
#11
Yik L Chan, Sonia Saad, Rita Machaalani, Brian G Oliver, Bryce Vissel, Carol Pollock, Nicole M Jones, Hui Chen
Hypoxic-ischemic (HI) encephalopathy occurs in approximately 6 per 1000 term newborns leading to devastating neurological consequences, such as cerebral palsy and seizures. Maternal smoking is one of the prominent risk factors contributing to HI injury. Mitochondrial integrity plays a critical role in neural injury and repair during HI. We previously showed that maternal cigarette smoke exposure (SE) can reduce brain mitochondrial fission and autophagosome markers in male offspring. This was accompanied by increased brain cell apoptosis (active caspase-3) and DNA fragmentation (TUNEL staining)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29018134/neuronal-sirt1-silent-information-regulator-2-homologue-1-regulates-glycolysis-and-mediates-resveratrol-induced-ischemic-tolerance
#12
Kevin B Koronowski, Nathalie Khoury, Isabel Saul, Zachary B Loris, Charles H Cohan, Holly M Stradecki-Cohan, Kunjan R Dave, Juan I Young, Miguel A Perez-Pinzon
BACKGROUND AND PURPOSE: Resveratrol, at least in part via SIRT1 (silent information regulator 2 homologue 1) activation, protects against cerebral ischemia when administered 2 days before injury. However, it remains unclear if SIRT1 activation must occur, and in which brain cell types, for the induction of neuroprotection. We hypothesized that neuronal SIRT1 is essential for resveratrol-induced ischemic tolerance and sought to characterize the metabolic pathways regulated by neuronal Sirt1 at the cellular level in the brain...
October 10, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29018130/mechanical-thrombectomy-in-perioperative-strokes-a-case-control-study
#13
Kévin Premat, Olivier Clovet, Giulia Frasca Polara, Eimad Shotar, Bruno Bartolini, Marion Yger, Federico Di Maria, Flore Baronnet, Silvia Pistocchi, Raphaël Le Bouc, Christine Pires, Nader Sourour, Sonia Alamowitch, Yves Samson, Vincent Degos, Frédéric Clarençon
BACKGROUND AND PURPOSE: Perioperative strokes (POS) are rare but serious complications for which mechanical thrombectomy could be beneficial. We aimed to compare the technical results and patients outcomes in a population of POS versus non-POS (nPOS) treated by mechanical thrombectomy. METHODS: From 2010 to 2017, 25 patients with POS (ie, acute ischemic stroke occurring during or within 30 days after a procedure) who underwent mechanical thrombectomy (POS group) were enrolled and paired with 50 consecutive patients with nPOS (control group), based on the occlusion's site, National Institute of Health Stroke Scale, and age...
October 10, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29017857/administration-of-5-methoxyindole-2-carboxylic-acid-that-potentially-targets-mitochondrial-dihydrolipoamide-dehydrogenase-confers-cerebral-preconditioning-against-ischemic-stroke-injury
#14
Jinzi Wu, Rongron Li, Wenjun Li, Ming Ren, Nopporn Thangthaeng, Nathalie Sumien, Ran Liu, Shaohua Yang, James W Simpkins, Michael J Forster, Liang-Jun Yan
The objective of this study was to investigate a possible role of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as a chemical preconditioning target for neuroprotection against ischemic injury. We used 5-methoxyindole-2-carboxylic acid (MICA), a reportedly reversible DLDH inhibitor, as the preconditioning agent and administered MICA to rats mainly via dietary intake. Upon completion of 4 week's MICA treatment, rats underwent 1h transient ischemia and 24h reperfusion followed by tissue collection. Our results show that MICA protected the brain against ischemic stroke injury as the infarction volume of the brain from the MICA-treated group was significantly smaller than that from the control group...
October 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29017609/effects-of-intra-arterial-transplantation-of-adipose-derived-stem-cells-on-the-expression-of-netrin-1-and-its-receptor-dcc-in-the-peri-infarct-cortex-after-experimental-stroke
#15
Huan Huang, Fan Lin, Jingjing Jiang, Yan Chen, Ainong Mei, Pengli Zhu
BACKGROUND: Stem cell transplantation has been documented to promote functional recovery in animal models of stroke; however, the underlying mechanisms are not yet fully understood. As netrin-1 and its receptor deleted in colorectal cancer (DCC) are important regulators in neuronal and vascular activities, the present study attempted to explore whether netrin-1 and DCC are involved in the neuroprotection of stem cell-based therapies in a rat ischemic stroke model. METHODS: Adult male Sprague-Dawley rats were subjected to a transient middle cerebral artery occlusion (MCAO) and subsequently received an intra-arterial injection of 2 × 10(6) PKH26-labeled adipose-derived stem cells (ADSCs) or saline 24 h later...
October 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29017492/electroacupuncture-ameliorating-post-stroke-cognitive-impairments-via-inhibition-of-peri-infarct-astroglial-and-microglial-macrophage-p2-purinoceptors-mediated-neuroinflammation-and-hyperplasia
#16
Jia Huang, Xiaofang You, Weilin Liu, Changming Song, Xiaomin Lin, Xiufeng Zhang, Jing Tao, Lidian Chen
BACKGROUND: During ischemic stroke (IS), adenosine 5'-triphosphate (ATP) is released from damaged nerve cells of the infract core region to the extracellular space, invoking peri-infarct glial cellular P2 purinoceptors singling, and causing pro-inflammatory cytokine secretion, which is likely to initiate or aggravate motor and cognitive impairment. It has been proved that electroacupuncture (EA) is an effective and safe strategy used in anti-inflammation. However, EA for the role of purine receptors in the central nervous system has not yet been reported...
October 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29016557/future-perspectives-of-cell-therapy-for-neonatal-hypoxic-ischemic-encephalopathy
#17
REVIEW
Makoto Nabetani, Haruo Shintaku, Takashi Hamazaki
Neonatal ischemic brain injury causes permanent motor-deficit cerebral palsy. Hypoxic-ischemic encephalopathy (HIE) is a very serious condition that can result in death and disability. In 1997, we reported that irreversible neuronal cell damage is induced by the elevation of intracellular Ca ion concentration that has occurred in sequence after excess accumulation of the excitatory neurotransmitter glutamate during ischemia. We also reported that hypothermia was effective in treating ischemic brain damage in rats by suppressing energy loss and raising intracellular Ca ion concentration...
October 10, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28994901/risk-of-first-onset-stroke-in-ssri-exposed-adult-subjects-survival-analysis-and-examination-of-age-and-time-effects
#18
Chin-Hong Chan, Hsiang-Hsiung Huang, Ching-Heng Lin, Yi-Chun Kuan, El-Wui Loh, Tsuo-Hung Lan
OBJECTIVE: Exposure to selective serotonin reuptake inhibitors (SSRIs) has been shown to increase the risk of stroke. In this study, we investigated age and time effects on the risk of first onset stroke in SSRI-exposed (SSRIEXP) adult subjects. METHODS: We analyzed an 8-year cohort from the National Health Insurance Research Database, Taiwan. Patients were defined as SSRIEXP subjects if they received SSRI prescriptions for at least 2 consecutive months during January 1, 2001, to December 31, 2007...
September 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28994754/a-magnetic-resonance-imaging-protocol-for-stroke-onset-time-estimation-in-permanent-cerebral-ischemia
#19
Bryony L McGarry, Kimmo T Jokivarsi, Michael J Knight, Olli H J Grohn, Risto A Kauppinen
MRI provides a sensitive and specific imaging tool to detect acute ischemic stroke by means of a reduced diffusion coefficient of brain water. In a rat model of ischemic stroke, differences in quantitative T1 and T2 MRI relaxation times (qT1 and qT2) between the ischemic lesion (delineated by low diffusion) and the contralateral non-ischemic hemisphere increase with time from stroke onset. The time dependency of MRI relaxation time differences is heuristically described by a linear function and thus provides a simple estimate of stroke onset time...
September 16, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28994171/brain-abscesses-caused-by-cladophialophora-bantiana-in-a-lung-transplant-patient-a-case-report-and-review-of-the-literature
#20
Anthony Gschwend, Tristan Dégot, Julie Denis, Alina M Sabou, Mi Young Jeung, Emilie Zapata, Michele Porzio, Benjamin Renaud-Picard, Raoul Herbrecht, Romain Kessler
Cladophialophora bantiana brain abscesses are rare, but are frequently and quickly lethal in transplanted patients. We report the case of a 63-year-old man who had undergone lung transplantation for chronic obstructive pulmonary disease and presented with headaches and a neurological deficit. Magnetic resonance imaging revealed multiple brain abscesses. C. bantiana was identified by DNA sequencing performed directly on cerebral tissue obtained by surgical biopsy. After 6 months of antifungal treatment, the brain abscesses were replaced by ischemic sequelae...
October 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
keyword
keyword
67148
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"