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https://www.readbyqxmd.com/read/28649083/report-prevalence-of-hospital-acquired-burkholderia-cepacia-infection-and-its-antimicrobial-susceptibility-in-a-chinese-hospital
#1
Jinju Duan, Jianbang Kang, Ting Han, Yuqin Ma, Qian Guo, Yan Song, Qiang Zhao, Yan Yang, Ruiqin Zhang
This study aimed to investigate antimicrobial susceptibility of hospital acquired Burkholderia cepacia infection in Shanxi (China) during August 2009 and December 2012. To characterize an emerging nocosomial infection. The medical records of 112 patients that were tested positive for B. cepacia were retrospectively analyzed. The K-B disk diffusion method was used to determine the drug susceptibility of the isolated strains. A hundred and fifty strains of B. cepacia were isolated from 112 patients. The sensitivity rates of B...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28644252/antineuroinflammation-of-minocycline-in-stroke
#2
Yi Chen, Zhiyou Cai, Zunyu Ke
Accumulating research substantiates the statement that inflammation plays an important role in the development of stroke. Both proinflammatory and anti-inflammatory mediators are involved in the pathogenesis of stroke, an imbalance of which leads to inflammation. Anti-inflammation is a kind of hopeful strategy for the prevention and treatment of stroke. Substantial studies have demonstrated that minocycline, a second-generation semisynthetic antibiotic belonging to the tetracycline family, can inhibit neuroinflammation, inflammatory mediators and microglia activation, and improve neurological outcome...
July 2017: Neurologist
https://www.readbyqxmd.com/read/28633753/tumor-necrosis-factor-induced-alopecia-alternative-pathology-and-therapy
#3
Jeremy Udkoff, Philip R Cohen
Tumor necrosis factor (TNF) inhibitors are used to treat Crohn disease and psoriasis. Although they are typically well tolerated, adverse effects include the development of alopecia, and paradoxically, psoriatic lesions. We recently described a woman with Crohn disease who developed alopecia and scalp psoriasis during infliximab therapy. After discontinuing infliximab and beginning oral and topical therapies, her alopecia completely resolved. We compared our experience with that of the Craddock et al. who described a woman with Crohn disease and alopecia secondary to adalimumab therapy...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28630942/antimalarial-drugs-and-the-prevalence-of-mental-and-neurological-manifestations-a-systematic-review-and-meta-analysis
#4
Mary A Bitta, Symon M Kariuki, Clifford Mwita, Samson Gwer, Leah Mwai, Charles R J C Newton
Background: Antimalarial drugs affect the central nervous system, but it is difficult to differentiate the effect of these drugs from that of the malaria illness. We conducted a systematic review to determine the association between anti-malarial drugs and mental and neurological impairment in humans.  Methods: We systematically searched online databases, including Medline/PubMed, PsychoInfo, and Embase, for articles published up to 14th July 2016. Pooled prevalence, heterogeneity and factors associated with prevalence of mental and neurological manifestations were determined using meta-analytic techniques...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28627277/anti-acne-drugs-in-phase-1-and-2-clinical-trials
#5
Christos C Zouboulis, Clio Dessinioti, Fragkiski Tsatsou, Harald P M Gollnick
Despite the impressive increase of knowledge on acne etiology accumulated during the last 20 years, few efforts have been overtaken to introduce new therapeutic regiments targeting the ideal treatment of acne. The increasing emergence of microbial resistance associated with antibiotics, teratogenicity, particularly associated with systemic isotretinoin, and the need for an adverse drug profile, which can be tolerated by the patient, make the need of new pathogenesis relevant anti-acne agents an emerging issue...
July 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28626377/kidney-injury-due-to-ureteral-obstruction-caused-by-compression-from-infected-simple-hepatic-cyst
#6
Naoya Sawada, Tetsu Endo, Kenichiro Mikami, Go Igarashi, Juichi Sakamoto, Hiroshi Tono, Shinsaku Fukuda
Simple hepatic cysts are common and most often asymptomatic. In symptomatic cases, hemorrhage, rupture, and infection are major complications. However, urinary tract obstruction caused by a simple hepatic cyst is rare. We treated an 82-year-old Japanese man with an infected giant hepatic cyst causing right hydronephrosis who had a past history of left nephrectomy for renal cell carcinoma. The patient underwent ultrasound-guided percutaneous drainage and sclerotherapy with minocycline hydrochloride for the infected hepatic cyst...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28624878/a-combination-of-three-repurposed-drugs-administered-at-reperfusion-as-a-promising-therapy-for-postischemic-brain-injury
#7
I-Chen Yu, Ping-Chang Kuo, Jui-Hung Yen, Hallel C Paraiso, Eric T Curfman, Benecia C Hong-Goka, Robert D Sweazey, Fen-Lei Chang
Cerebral ischemia leads to multifaceted injury to the brain. A polytherapeutic drug that can be administered immediately after reperfusion may increase protection to the brain by simultaneously targeting multiple deleterious cascades. This study evaluated efficacy of the combination of three clinically approved drugs: lamotrigine, minocycline, and lovastatin, using two mouse models: global and focal cerebral ischemia induced by transient occlusion of the common carotid arteries or the middle cerebral artery, respectively...
June 17, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28622620/simultaneous-uhplc-uv-analysis-of-hydroxychloroquine-minocycline-and-doxycycline-from-serum-samples-for-the-therapeutic-drug-monitoring-of-q-fever-and-whipple-s-disease
#8
Nicholas Armstrong, Magali Richez, Didier Raoult, Eric Chabriere
A fast UHPLC-UV method was developed for the simultaneous analysis of Hydroxychloroquine, Minocycline and Doxycycline drugs from 100μL of human serum samples. Serum samples were extracted by liquid-liquid extraction and injected into a phenyl hexyl reverse phase column. Compounds were separated using a mobile phase linear gradient and monitored by UV detection at 343nm. Chloroquine and Oxytetracycline were used as internal standards. Lower and upper limits of quantifications, as well as the other levels of calibration, were validated with acceptable accuracy (<15% deviation) and precision (<15% coefficient of variation) according to the European Medicines Agency guidelines...
June 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28621909/systemic-therapy-of-ocular-and-cutaneous-rosacea-in-children
#9
L I Gonser, C E Gonser, C Deuter, M Heister, M Zierhut, M Schaller
BACKGROUND: In paediatric rosacea, ocular symptoms are often predominant. Literature about systemic therapy of paediatric ocular rosacea is sparse, though. OBJECTIVE: Analysis of children with ocular rosacea treated systemically, particularly addressing remission and recurrence rates. METHODS: Retrospective study reviewing the medical records of children with ocular rosacea treated with systemic antibiotic therapy. Nine out of 19 patients were chosen for detailed analysis...
June 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28616020/minocycline-targets-multiple-secondary-injury-mechanisms-in-traumatic-spinal-cord-injury
#10
REVIEW
Robert B Shultz, Yinghui Zhong
Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant, and anti-apoptotic properties. The secondary injury mechanisms that MH can potentially target include inflammation, free radicals and oxidative stress, glutamate excitotoxicity, calcium influx, mitochondrial dysfunction, ischemia, hemorrhage, and edema...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28615336/prevention-and-reversal-of-latent-sensitization-of-dorsal-horn-neurons-by-glial-blockers-in-a-model-of-low-back-pain-in-male-rats
#11
Juanjuan Zhang, Siegfried Mense, Rolf-Detlef Treede, Ulrich Hoheisel
In an animal model of non-specific low back pain, recordings from dorsal horn neurons were made to investigate the influence of glial cells in the central sensitization process. To induce a latent sensitization of the neurons, nerve growth factor (NGF) was injected into the multifidus muscle; the manifest sensitization to a second NGF injection 5 days later was used as a read-out. The sensitization manifested in increased resting activity and in an increased proportion of neurons responding to stimulation of deep somatic tissues...
June 14, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28612530/-minocycline-prevent-microglial-activation-via-suppression-of-adenosine-a-2a-receptor-in-a-rat-stroke-ischemia-reperfusion-model
#12
Tao Tao, Jie Fu, Yong-Gang Liu, Zuo-Xiao Li, Xiao-Gang Li
OBJECTIVES: To investigate whether minocycline could inhibit neuroinflammation induced by microglia activation through suppression of adenosine A2Areceptor (A2AR)expression in rats after cerebral ischemia/reperfusion (I/R) injury. METHODS: Thirty male Sprageue-Dawley rats were randomly divided into 3 groups: sham group, I/R group and minocycline group. The rats were subjected to occlusion of the right middle cerebral artery (MCAO) for 2 h to establish stroke I/R model, and 3 mg/kg minocycline was injected intravenously immediately after reperfusion twice a day in minocycline group...
March 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28608142/erratum-to-antinociceptive-interaction-of-gabapentin-with-minocycline-in-murine-diabetic-neuropathy
#13
H F Miranda, F Sierralta, V Jorquera, P Poblete, J C Prieto, V Noriega
No abstract text is available yet for this article.
June 12, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28599348/a-pilot-open-label-8-week-study-evaluating-the-efficacy-safety-and-tolerability-of-adjunctive-minocycline-for-the-treatment-of-bipolar-i-ii-depression
#14
Joanna K Soczynska, Sidney H Kennedy, Mohammad Alsuwaidan, Rodrigo B Mansur, Madeline Li, Mary Pat McAndrews, Elisa Brietzke, Hanna O Woldeyohannes, Valerie H Taylor, Roger S McIntyre
OBJECTIVES: The objectives of the study were to determine if adjunctive minocycline mitigates depressive symptom severity and improves cognitive function in individuals with bipolar I/II disorder (BD). The study also aimed to determine if changes in depressive and/or cognitive symptoms over the course of treatment were associated with changes in circulating inflammatory cytokine levels. METHODS: A total of 29 (intention-to-treat: n=27) adults meeting DSM-IV-TR criteria for a major depressive episode as part of bipolar I or II disorder (i...
May 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28598549/the-presence-of-minocycline-in-the-tear-film-of-normal-horses-following-oral-administration-and-its-anticollagenase-activity
#15
Caroline S Monk, Sun Young Jeong, Daniel James Gibson, Caryn E Plummer
PURPOSE: Tetracyclines have activity against matrix metalloproteinases (MMP). Oral medications with effects on the ocular surface are of interest in patients where repeated topical dosing is limited. The aim of this study was to characterize the concentration of minocycline in the tears of normal horses after oral administration and to determine if this level directly inhibits MMP activity. METHODS: Five healthy adult ponies were administered oral minocycline (Wedgewood Pharmacy; Swedesboro, NJ) at 4 mg/kg every 12 h for 5 days...
June 9, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28592198/reversible-drug-induced-antiphospholipid-syndrome
#16
J Risse, M Vieira, F Beuret, N Petitpain, S Zuily, D Wahl
We report an original case of reversible antiphospholipid syndrome (APS) due to minocycline in a young male patient who experienced recurrent strokes while taking minocycline. He started minocycline therapy (50 mg twice daily) at 15 years old for acne. After three years of treatment, the patient experienced a lateral medullary syndrome. He was treated with aspirin while minocycline was continued. Eighteen months later, the patient complained about horizontal binocular diplopia. MRI revealed an infarct of the oculomotor nerve nucleus...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28585113/sex-dependent-glial-signaling-in-pathological-pain-distinct-roles-of-spinal-microglia-and-astrocytes
#17
Gang Chen, Xin Luo, M Yawar Qadri, Temugin Berta, Ru-Rong Ji
Increasing evidence suggests that spinal microglia regulate pathological pain in males. In this study, we investigated the effects of several microglial and astroglial modulators on inflammatory and neuropathic pain following intrathecal injection in male and female mice. These modulators were the microglial inhibitors minocycline and ZVEID (a caspase-6 inhibitor) and the astroglial inhibitors L-α-aminoadipate (L-AA, an astroglial toxin) and carbenoxolone (a connexin 43 inhibitor), as well as U0126 (an ERK kinase inhibitor) and D-JNKI-1 (a c-Jun N-terminal kinase inhibitor)...
June 5, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28581215/minocycline-as-an-alternative-to-doxycycline-in-the-treatment-of-rosacea
#18
A M Two
No abstract text is available yet for this article.
June 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28579455/killing-kinetics-of-minocycline-doxycycline-and-tosufloxacin-against-macrolide-resistant-mycoplasma-pneumoniae
#19
Miyuki Morozumi, Takafumi Okada, Takeshi Tajima, Kimiko Ubukata, Satoshi Iwata
Macrolide-resistant Mycoplasma pneumoniae (MRMP) has emerged and is increasing worldwide. In a 2011 outbreak of MRMP infections in Japan, symptoms failed to improve in many patients who initially received macrolides; the therapeutic agent was then changed to minocycline (MIN), doxycycline (DOX) or tosufloxacin (TFX). In this study, the bactericidal effects of these three agents against MRMP were evaluated. Time-kill kinetics against MRMP and macrolide-susceptible M. pneumoniae (MSMP) were determined over 5 days at concentrations corresponding to the respective minimum inhibitory concentration (MIC) and 2× MIC, i...
June 1, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28578592/adjunctive-minocycline-treatment-for-major-depressive-disorder-a-proof-of-concept-trial
#20
Olivia M Dean, Buranee Kanchanatawan, Melanie Ashton, Mohammadreza Mohebbi, Chee Hong Ng, Michael Maes, Lesley Berk, Atapol Sughondhabirom, Sookjaroen Tangwongchai, Ajeet B Singh, Helen McKenzie, Deidre J Smith, Gin S Malhi, Nathan Dowling, Michael Berk
OBJECTIVE: Conventional antidepressant treatments result in symptom remission in 30% of those treated for major depressive disorder, raising the need for effective adjunctive therapies. Inflammation has an established role in the pathophysiology of major depressive disorder, and minocycline has been shown to modify the immune-inflammatory processes and also reduce oxidative stress and promote neuronal growth. This double-blind, randomised, placebo-controlled trial examined adjunctive minocycline (200 mg/day, in addition to treatment as usual) for major depressive disorder...
June 1, 2017: Australian and New Zealand Journal of Psychiatry
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