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https://www.readbyqxmd.com/read/28108677/in-vitro-susceptibility-to-19-agents-other-than-%C3%AE-lactams-among-third-generation-cephalosporin-resistant-enterobacteriaceae-recovered-on-hospital-admission
#1
A Mischnik, P Baumert, A Hamprecht, A M Rohde, S Peter, S Feihl, J Knobloch, H Gölz, A Kola, B Obermann, C Querbach, M Willmann, F Gebhardt, E Tacconelli, P Gastmeier, H Seifert, W V Kern
OBJECTIVES: As part of the multicentre Antibiotic Therapy Optimisation Study, MIC values of 19 non-β-lactam agents were determined for third-generation cephalosporin-resistant Escherichia coli, Klebsiella species and Enterobacter species (3GCREB) isolates collected in German hospitals. METHODS: A total of 328 E. coli, 35 Klebsiella spp. (1 Klebsiella oxytoca and 34 Klebsiella pneumoniae) and 16 Enterobacter spp. (1 Enterobacter aerogenes and 15 Enterobacter cloacae) isolates were submitted to broth microdilution antimicrobial susceptibility testing with the MICRONAUT system...
January 19, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28100653/minocycline-blocks-glial-cell-activation-and-ventilatory-acclimatization-to-hypoxia
#2
Jennifer Ann Stokes, Tara Elizabeth Arbogast, Esteban A Moya, Zhenxing Fu, Frank L Powell
Ventilatory acclimatization to hypoxia (VAH) is the time-dependent increase in ventilation, which persists upon return to normoxia, and involves plasticity in both central nervous system respiratory centers and peripheral chemoreceptors. We investigated the role of glial cells in VAH in male Sprague Dawley rats using minocycline, an antibiotic that inhibits microglia activation and has anti-inflammatory properties, and barometric pressure plethysmography to measure ventilation. Rats received either minocycline (45mg/kg, i...
January 18, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28092020/early-life-social-isolation-induced-depressive-like-behavior-in-rats-results-in-microglial-activation-and-neuronal-histone-methylation-that-are-mitigated-by-minocycline
#3
Hong-Tao Wang, Fu-Lian Huang, Zhao-Lan Hu, Wen-Juan Zhang, Xiao-Qing Qiao, Yan-Qing Huang, Ru-Ping Dai, Fang Li, Chang-Qi Li
Early-life stress is a potent risk factor for development of psychiatric conditions such as depression. The underlying mechanisms remain poorly understood. Here, we used the early-life social isolation (ESI) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microglia, levels of histone methylation, as well as expression of glutamate receptor subunits in the hippocampus. We found that depressive-like behavior was induced after ESI as determined by sucrose preference and forced swimming tests...
January 16, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28090041/clinical-characteristics-of-stenotrophomonas-maltophilia-bacteremia-a-regional-report-and-a-review-of-a-japanese-case-series
#4
Hirotaka Ebara, Hideharu Hagiya, Yuto Haruki, Eisei Kondo, Fumio Otsuka
Objective Stenotrophomonas maltophilia is an emerging nosocomial pathogen that causes fatal infections in critically ill or immunocompromised patients. S. maltophilia bacteremia (SMB) is a rare condition, and its clinical characteristics in Japanese settings are not well known. Methods The medical charts of patients with SMB were retrospectively reviewed at two medical facilities (Okayama University Hospital and Tsuyama Chuo Hospital) for seven years. The data were analyzed along with those previously reported from other Japanese facilities...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28079834/intestinal-brucellosis-associated-with-celiac-artery-and-superior-mesenteric-artery-stenosis-and-with-ileum-mucosa-and-submucosa-thickening-a-case-report
#5
Miaoqian Wang, Qingli Zhu, Qian Yang, Wenbo Li, Xinning Wang, Wei Liu, Baotong Zhou, Zhenghong Li, Hong Yang
RATIONALE: Brucellosis is a multisystem infection found worldwide that has a broad range of characteristics, which range from acute fever and hepatomegaly to chronic infections that most commonly affect the central nervous system, cardiovascular system, or skeletal system. Gastrointestinal and splanchnic artery involvements in brucellosis are relatively uncommon. PATIENT CONCERNS: We report a case of brucellosis in an adolescent presenting as intermittent abdominal pain, diarrhea, and fever, with intestinal tract involvement...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28073678/natural-potential-neuroinflammatory-inhibitors-from-alhagi-sparsifolia-shap
#6
Di Zhou, Hongyan Wei, Zhe Jiang, Xuezheng Li, Kun Jiao, Xiaoguang Jia, Yue Hou, Ning Li
Neuroinflammation is a key contributor to neuronal damage in neurodegenerative diseases. In our previous work on natural effective neuroinflammatory inhibitors, Alhagi sparsifolia Shap. (Leguminosae), a folk medicine widely distributed in Xinjiang, attracted our attention because of its significant anti-neuroinflammatory effect. Therefore, further investigation of the bioactive material basis was carried out. As a result, 33 major components were characterized and identified by chromatographic and spectral methods, respectively...
December 30, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28069512/minocycline-enhances-the-mesenchymal-stromal-stem-cell-pro-healing-phenotype-in-triple-antimicrobial-loaded-hydrogels
#7
Alberto Daniel Guerra, Warren E Rose, Peiman Hematti, W John Kao
: Mesenchymal stromal/stem cells (MSCs) have demonstrated pro-healing properties including an anti-inflammatory cytokine profile and the promotion of angiogenesis via expression of growth factors in pre-clinical models. MSCs encapsulated in poly(ethylene glycol) diacrylate (PEGdA) and thiolated gelatin poly(ethylene glycol) (Gel-PEG-Cys) crosslinked hydrogels have led to controlled cellular presentation at wound sites with favorable wound healing outcomes. However, the therapeutic potential of MSC-loaded hydrogels may be limited by non-specific protein adsorption on the delivery matrix that could facilitate the initial adhesion of microorganisms and subsequent virulent biofilm formation...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28062293/distribution-of-resistance-genetic-determinants-among-vibrio-cholerae-isolates-of-2012-and-2013-outbreaks-in-ir-iran
#8
Niloofar Rezaie, Bita Bakhshi, Shahin Najar-Peerayeh
The objective of this study was to characterize antimicrobial resistance determinants in relation to antimicrobial susceptibility and genotyping profile in 20 clinical isolates of Vibrio cholerae. All of the isolates were resistant to streptomycin. The second most prevalent resistance was observed to trimethoprim (75%), co-trimoxazole (60%), tetracycline (50%), and minocycline (45%). About 50% of the isolates fulfilled the criteria of Multi Drug Resistance (MDR) phenotype. None of the isolates carried tet A, B, C, and, D determinants...
January 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28060985/-febrile-ulceronecrotic-mucha-habermann-disease
#9
Javier Arellano Lorca, Ignacio Yáñez Silva, Felipe Soto Vilches, Andrea Luna Heine, Yamile Corredoira Salum
Pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic Mucha-Habermann disease (FUMHD) are considered different manifestations of the same disease. Febrile ulceronecrotic Mucha-Habermann disease is a rare, and potentially lethal illness which is characterized by fast progression of numerous papules that converge, ulcerate and form a plaque with a necrotic center, together with hemorrhagic vesicles and pustules that are associated with high fever and variable systemic symptoms...
September 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28056222/in-vitro-activity-of-antimicrobial-agents-against-multidrug-and-extensively-drug-resistant-acinetobacter-baumannii
#10
Francielli Mahnic Vasconcellos, Monique Ribeiro Tiba Casas, Lais Calissi Brisolla Tavares, Doroti Oliveira Garcia, Carlos Henrique Camargo
Multidrug- (MDR) and extensively drug-resistant (XDR) Acinetobacter baumannii (Ab) difficult the treatment of severe infections. We evaluated the in vitro activity of antimicrobial agents against 71 carbapenem-resistant clonal diverse clinical Ab strains recovered from Brazilian hospitals. Minocycline and polypeptides presented activity against >98% of the isolates, indicating their potential against MDR or XDR carbapenem-resistant Acinetobacter baumannii from main clones circulating in Brazil.
January 5, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28056021/comparison-of-doxycycline-minocycline-doxycycline-plus-albendazole-and-albendazole-alone-in-their-efficacy-against-onchocerciasis-in-a-randomized-open-label-pilot-trial
#11
Ute Klarmann-Schulz, Sabine Specht, Alexander Yaw Debrah, Linda Batsa, Nana Kwame Ayisi-Boateng, Jubin Osei-Mensah, Yusif Mubarik, Peter Konadu, Arcangelo Ricchiuto, Rolf Fimmers, Sandra Arriens, Bettina Dubben, Louise Ford, Mark Taylor, Achim Hoerauf
: The search for new macrofilaricidal drugs against onchocerciasis that can be administered in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4-6 weeks), identified minocycline (MIN) with superior efficacy to DOX. Further reduction in the treatment regimen may be achieved with co-administration with standard anti-filarial drugs. Therefore a randomized, open-label, pilot trial was carried out in an area in Ghana endemic for onchocerciasis, comprising 5 different regimens: the standard regimen DOX 200mg/d for 4 weeks (DOX 4w, N = 33), the experimental regimens MIN 200mg/d for 3 weeks (MIN 3w; N = 30), DOX 200mg/d for 3 weeks plus albendazole (ALB) 800mg/d for 3 days (DOX 3w + ALB 3d, N = 32), DOX 200mg/d for 3 weeks (DOX 3w, N = 31) and ALB 800mg for 3 days (ALB 3d, N = 30)...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28054351/hidradenitis-suppurativa-treated-with-tetracycline-in-combination-with-colchicine-a-prospective-series-of-20-patients
#12
Kalliopi Armyra, Anargyros Kouris, Vasiliki Markantoni, Andreas Katsambas, George Kontochristopoulos
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of the follicular epithelium. OBJECTIVES: The objective of the present study was to evaluate the effectiveness of the combination of tetracycline with colchicine in the treatment of HS. METHODS: Twenty patients (10 women and 10 men) with HS were included in an open, prospective, pilot study. All patients were treated with 100 mg minocycline administered orally once per day in combination with 0...
January 4, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28053913/corrigendum-microbiological-and-clinical-effects-of-enamel-matrix-derivative-and-sustained-release-micro-spherical-minocycline-application-as-an-adjunct-to-non-surgical-therapy-in-peri-implant-mucosal-inflammation
#13
Masumeh Faramarzi, Zahra Goharfar, Reza Pourabbas, Atabak Kashefimehr, Adileh Shirmohammadi
[This corrects the article on p. 181 in vol. 41, PMID: 26339576.].
December 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28050350/diffuse-skin-hyperpigmentation-associated-with-chronic-minocycline-use-in-a-patient-with-prosthetic-joint-infection
#14
Hadi Berbari, Elie F Berbari, Irene G Sia
Cutaneous hyperpigmentation is a recognized adverse effect of chronic minocycline use occurring in up to 50% of patients. In this report we present a rare case of extensive skin hyperpigmentation involving both lower extremities in a patient receiving long term minocycline. The patient was receiving minocycline as suppression for chronic prosthetic joint infection. Risk factors associated with minocycline-induced cutaneous pigmentation (MICH) will be reviewed.
2017: IDCases
https://www.readbyqxmd.com/read/28041945/knockdown-transgenic-lrrk-drosophila-resists-paraquat-induced-locomotor-impairment-and-neurodegeneration-a-therapeutic-strategy-for-parkinson-s-disease
#15
Diana Quintero-Espinosa, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo
Leucine-rich repeat kinase 2 (LRRK2) has been linked to familial and sporadic Parkinson's disease. However, it is still unresolved whether LRRK2 in dopaminergic (DAergic) neurons may or may not aggravate the phenotype. We demonstrate that knocking down (KD) the Lrrk gene by RNAi in DAergic neurons untreated or treated with paraquat (PQ) neither affected the number of DAergic clusters, tyrosine hydroxylase (TH) protein levels, lifespan nor locomotor activity when compared to control (i.e. TH/+) flies. KD transgenic Lrrk flies dramatically increased locomotor activity in presence of TH enzyme inhibitor alpha-methyl-para-tyrosine (aMT), whereas no effect on lifespan was observed in both fly lines...
December 29, 2016: Brain Research
https://www.readbyqxmd.com/read/28039043/cathepsin-s-in-the-spinal-microglia-contributes-to-remifentanil-induced-hyperalgesia-in-rats
#16
L Ye, L Xiao, S Y Yang, J J Duan, Y Chen, Y Cui, Y Chen
Cysteine protease cathepsin S (CatS) expressed by spinal microglia has been shown to play a critical role in nerve injury and inflammation-induced chronic pain. However, whether microglial CatS contributes to remifentanil-induced acute hyperalgesia remains unstudied. In the present study, intravenous remifentanil infusion induced a significant increase in the expression of premature and mature form of CatS in the activated microglia in the spinal cord. Spinal delivery of irreversible CatS inhibitor LHVS reduced hyperalgesia, attenuated activation of spinal microglia and blocked phosphorylation of N-methyl-d-aspartate (NMDA) receptor NR1 subunit induced by remifentanil...
December 28, 2016: Neuroscience
https://www.readbyqxmd.com/read/28038986/differential-effects-of-minocycline-on-microglial-activation-and-neurodegeneration-following-closed-head-injury-in-the-neonate-rat
#17
L A Hanlon, R Raghupathi, J W Huh
The role of microglia in the pathophysiology of injury to the developing brain has been extensively studied. In children under the age of 4 who have sustained a traumatic brain injury (TBI), markers of microglial/macrophage activation were increased in the cerebrospinal fluid and were associated with worse neurologic outcome. Minocycline is an antibiotic that decreases microglial/macrophage activation following hypoxic-ischemia in neonatal rodents and TBI in adult rodents thereby reducing neurodegeneration and behavioral deficits...
December 27, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/28036021/monitoring-the-response-of-hyperbilirubinemia-in-the-mouse-brain-by-in-vivo-bioluminescence-imaging
#18
Isabella Manni, Giuliana Di Rocco, Salvatore Fusco, Lucia Leone, Saviana Antonella Barbati, Carmine Maria Carapella, Claudio Grassi, Giulia Piaggio, Gabriele Toietta
Increased levels of unconjugated bilirubin are neurotoxic, but the mechanism leading to neurological damage has not been completely elucidated. Innovative strategies of investigation are needed to more precisely define this pathological process. By longitudinal in vivo bioluminescence imaging, we noninvasively visualized the brain response to hyperbilirubinemia in the MITO-Luc mouse, in which light emission is restricted to the regions of active cell proliferation. We assessed that acute hyperbilirubinemia promotes bioluminescence in the brain region, indicating an increment in the cell proliferation rate...
December 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28033297/could-lengthening-minocycline-therapy-better-treat-early-syphilis
#19
Li-Li Shao, Rui Guo, Wei-Jie Shi, Yuan-Jun Liu, Bin Feng, Long Han, Quan-Zhong Liu
Syphilis is a sexually transmitted disease caused by Treponema pallidum. Minocycline, a representative tetracycline derivative, has the greatest antimicrobial activity among all tetracyclines. There are few reports about treating syphilis with minocycline because there is a lack of efficacy data from controlled trials. We compared the rates of serological cure in patients with early syphilis who were treated with minocycline or benzathine penicillin G (BPG).During the study period, a total of 40 syphilis patients received the BPG treatment, which was a single intramuscular dose of 2...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28031712/minocycline-and-celecoxib-as-adjunctive-treatments-for-bipolar-depression-a-study-protocol-for-a-multicenter-factorial-design-randomized-controlled-trial
#20
Muhammad I Husain, Imran B Chaudhry, Munir M Hamirani, Fareed A Minhas, Ajmal Kazmi, John Hodsoll, Peter M Haddad, John Fw Deakin, Nusrat Husain, Allan H Young
BACKGROUND: Evidence suggests that the use of anti-inflammatory agents may improve depressive symptoms in patients with bipolar affective disorder. However, there are few well-designed clinical trials demonstrating the efficacy of these newer treatment strategies. PATIENTS AND METHODS: This is a multicenter, 3-month, randomized, placebo-controlled, double-blind, factorial design trial of minocycline and/or celecoxib added to TAU for the treatment of depressive symptoms in patients experiencing a DSM-5 bipolar I or II disorder and a current major depressive episode...
2017: Neuropsychiatric Disease and Treatment
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