keyword
https://read.qxmd.com/read/38490109/neutrophils-an-emerging-new-therapeutic-platform
#21
REVIEW
Alejandra López-Arredondo, José A Cruz-Cardenas, Jorge A Cázares-Preciado, Nicholas E Timmins, Marion Eg Brunck
Neutrophils possess unique characteristics that render them indispensable to health, and patients with irregular neutrophil counts or functions suffer from increased morbidity and mortality. As neutrophils are short-lived postmitotic cells, genetic aberrations cannot be corrected directly in neutrophils and must be targeted in their progenitors. Neutrophils are increasingly being contemplated for a range of therapeutic applications, including restoration or modulation of immune function and targeting of solid tumors...
March 13, 2024: Current Opinion in Biotechnology
https://read.qxmd.com/read/38489475/a-comparative-analysis-of-the-antibacterial-spectrum-of-ultrasmall-manganese-ferrite-nanozymes-with-varied-surface-modifications
#22
JOURNAL ARTICLE
Junhua Han, Yingxian Chen, Xin Xiang, Tingting Wang, Jianzhong Shen, Nan Zhang, Chen Liang, Xiaoli Liu, Xiaowei Ma
Bacterial infectious diseases pose a significant global challenge. However, conventional antibacterial agents exhibit limited therapeutic effectiveness due to the emergence of drug resistance, necessitating the exploration of novel antibacterial strategies. Nanozymes have emerged as a highly promising alternative to antibiotics, owing to their particular catalytic activities against pathogens. Herein, we synthesized ultrasmall-sized MnFe2 O4 nanozymes with different charges (MnFe2 O4 -COOH, MnFe2 O4 -PEG, MnFe2 O4 -NH2 ) and assessed their antibacterial capabilities...
March 15, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38487535/understanding-covid-19-associated-endothelial-dysfunction-role-of-piezo1-as-a-potential-therapeutic-target
#23
REVIEW
Xiaoting Zhang, Jinhai Liu, Xiaoming Deng, Lulong Bo
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Due to its high infectivity, the pandemic has rapidly spread and become a global health crisis. Emerging evidence indicates that endothelial dysfunction may play a central role in the multiorgan injuries associated with COVID-19. Therefore, there is an urgent need to discover and validate novel therapeutic strategies targeting endothelial cells. PIEZO1, a mechanosensitive (MS) ion channel highly expressed in the blood vessels of various tissues, has garnered increasing attention for its potential involvement in the regulation of inflammation, thrombosis, and endothelial integrity...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38487193/patients-response-during-the-co-circulation-of-multiple-respiratory-diseases-in-china-based-on-the-self-regulation-common-sense-model
#24
JOURNAL ARTICLE
Shanwen Sun, Yali Wang, Hailong Hou, Yuqi Niu, Yefan Shao, Linlin Chen, Xiaochun Zhang
BACKGROUND: Following the COVID-19 pandemic, another large-scale respiratory epidemic has emerged in China, causing significant social impact and disruption. The article is to explore the patients' psychological and behavioral responses to the enhancement of healthcare quality. METHODS: Based on the five dimensions of the Self-Regulation Common-Sense Model, we developed an interview outline to explore the process by which patients identify disease symptoms to guide action plans and coping strategies...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38486815/attributable-cost-of-adult-respiratory-syncytial-virus-illness-beyond-the-acute-phase
#25
JOURNAL ARTICLE
Ahuva Averin, Mark Atwood, Reiko Sato, Kari Yacisin, Elizabeth Begier, Kimberly Shea, Daniel Curcio, Linnea Houde, Derek Weycker
BACKGROUND: Estimates of the cost of medically attended lower respiratory tract illness (LRTI) due to respiratory syncytial virus (RSV) in adults, especially beyond the acute phase, is limited. This study was undertaken to estimate the attributable costs of RSV-LRTI among US adults during, and up to 1 year after, the acute phase of illness. METHODS: A retrospective observational matched-cohort design and a US healthcare claims repository (2016-2019) were employed...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38486662/quality-availability-and-suitability-of-antimicrobial-stewardship-guidance-a-multinational-qualitative-study
#26
JOURNAL ARTICLE
Zane Linde-Ozola, Annika Y Classen, Christian G Giske, Siri Göpel, Noa Eliakim-Raz, Makeda Semret, Gunnar Skov Simonsen, Jörg Janne Vehreschild, Silje Bakken Jørgensen, Johanna Kessel, Lars Kåre Selland Kleppe, Dorthea Hagen Oma, Maria J G T Vehreschild, Aija Vilde, Uga Dumpis
BACKGROUND: Antimicrobial stewardship (AMS) programmes are established across the world to treat infections efficiently, prioritize patient safety, and reduce the emergence of antimicrobial resistance. One of the core elements of AMS programmes is guidance to support and direct physicians in making efficient, safe and optimal decisions when prescribing antibiotics. To optimize and tailor AMS, we need a better understanding of prescribing physicians' experience with AMS guidance. OBJECTIVES: To explore the prescribing physicians' user experience, needs and targeted improvements of AMS guidance in hospital settings...
April 2024: JAC-antimicrobial resistance
https://read.qxmd.com/read/38486340/climate-influenced-vector-borne-diseases-in-africa-a-call-to-empower-the-next-generation-of-african-researchers-for-sustainable-solutions
#27
JOURNAL ARTICLE
Judicaël Obame-Nkoghe, Adjoavi Esse Agossou, Gerald Mboowa, Basile Kamgang, Cyril Caminade, Dawn C Duke, Andrew Karanja Githeko, Obed M Ogega, Nestor Engone Elloué, Fatou Bintou Sarr, Dieudonné Nkoghe, Pierre Kengne, Nicaise T Ndam, Christophe Paupy, Moses Bockarie, Patricks Voua Otomo
We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges...
March 14, 2024: Infectious Diseases of Poverty
https://read.qxmd.com/read/38486152/isolation-and-characterization-of-lytic-bacteriophages-from-various-sources-in-addis-ababa-against-antimicrobial-resistant-diarrheagenic-escherichia-coli-strains-and-evaluation-of-their-therapeutic-potential
#28
JOURNAL ARTICLE
Tamirat Salile Sada, Tesfaye Sisay Tessema
BACKGROUND: Escherichia coli is a common fecal coliform, facultative aerobic, gram-negative bacterium. Pathogenic strains of such microbes have evolved to cause diarrhea, urinary tract infections, and septicemias. The emergence of antibiotic resistance urged the identification of an alternative strategy. The use of lytic bacteriophages against the control of pathogenic E. coli in clinics and different environmental setups (waste and drink water management) has become an alternative therapy to antibiotic therapy...
March 14, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38484348/pulmonary-abscess-with-atypical-topography-computed-tomography-assessment-before-and-after-treatment
#29
JOURNAL ARTICLE
Cristina Asvolinsque Pantaleão Fontes, Mary Lúcia Bedran Ananias, Juliana Garcia Alves da Trindade
INTRODUCTION: We present a clinical case of a patient with neurological sequelae, dementia, gastrostomy and tracheostomy with a metal canula, who developed a lung abscess in an atypical topography, in the anterior segment of the left upper lobe, being attended to in the emergency department. CASE PRESENTATION: A 79-year-old man who was bedridden and with neurological sequelae resulting from a hemorrhagic stroke, with gastrostomy and tracheostomy with a metal canula, was attended for daily fever and increased secretion trough the canula, and a diagnosis of bronchoaspiration pneumonia was made...
February 29, 2024: Journal of Infection in Developing Countries
https://read.qxmd.com/read/38483872/the-health-and-safety-experiences-of-precariously-employed-bangladeshi-immigrant-workers-in-toronto-during-the-covid-19-pandemic
#30
JOURNAL ARTICLE
Stephanie Premji, Momtaz Begum, Kishower Laila, Sultana Jahangir, Adam Zvric
Racialized immigrants in Canada have been disproportionately impacted by the COVID-19 pandemic. Our qualitative, community-based study with South Asian Women and Immigrants' Services examined the impact of the second and third waves of the pandemic on the work and health of precariously employed Bangladeshi immigrant women and men in Toronto. Our study is based on interviews and focus group discussions with 45 workers, all conducted in Bangla, and 11 key informants. Interviews reveal work transitions, an increase in precarity, work in essential sectors, exposures at work, home and in transit, workplace prevention and management gaps, and an inability to take time off, with significant impacts on workers' physical and mental health...
March 14, 2024: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://read.qxmd.com/read/38483775/household-influenza-transmission-and-healthcare-resource-utilization-among-patients-treated-with-baloxavir-vs-oseltamivir-a-united-states-outpatient-prospective-survey
#31
JOURNAL ARTICLE
Jennie H Best, Mitra Sadeghi, Xiaowu Sun, Arpamas Seetasith, Lisa Albensi, Seema Joshi, Marcus J Zervos
INTRODUCTION: Influenza is a common, seasonal infectious disease with broad medical, economic, and social consequences. Real-world evidence on the effect of influenza treatment on household transmission and healthcare resource utilization is limited in outpatient settings in the USA. This study examined the real-world effectiveness of baloxavir vs oseltamivir in reducing influenza household transmission and healthcare resource utilization. METHODS: This prospective electronic survey on patient-reported outcomes was conducted between October 2022 and May 2023 via CVS Pharmacy in the USA...
March 14, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38482849/biodegradable-lipid-modified-poly-guanidine-thioctic-acid-s-a-fortifier-of-lipid-nanoparticles-to-promote-the-efficacy-and-safety-of-mrna-cancer-vaccines
#32
JOURNAL ARTICLE
Kai Yang, Bing Bai, Jiaqi Lei, Xinyang Yu, Shaolong Qi, Yangfan Wang, Feihe Huang, Zaizai Tong, Guocan Yu
Lipid nanoparticles (LNPs)-based messenger RNA (mRNA) therapeutics have emerged with promising potentials in the fields of infectious diseases, cancer vaccines, and protein replacement therapies; however, their therapeutic efficacy and safety can still be promoted by the optimization of LNPs formulations. Unfortunately, current LNPs suffer from increased production of reactive oxygen species during translation, which leads to a decreased translation efficiency and the onset of inflammation and other side effects...
March 14, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38482535/outcomes-symptomatology-and-mortality-of-children-presenting-with-bacterial-meningitis-at-allied-hospitals-of-rawalpindi-medical-university-pakistan-a-cross-sectional-study
#33
JOURNAL ARTICLE
Muhammad Zarak Khan, Aiman Waheed, Faizan Fazal, Shahrukh Ahmad Khan, Ehsan Ahmad, Sanan Rasheed, Talha Ijaz, Areesha Abid, Saima Ambreen, Bilal Haider Malik
Introduction Bacterial meningitis (BM) is a neurologic emergency mainly affecting children under the age of two. Clinical symptoms are rarely evident in children, thus making a diagnosis is a challenge. Antibiotic therapy should be started timely to ensure the avoidance of significant morbidity and mortality. This study aims to assess the outcomes, mortality, and symptomatology of children presenting with BM in allied hospitals of Rawalpindi Medical University, Pakistan. Methods It is a cross-sectional study employing a sample size of 201, conducted at the Allied Hospitals of Rawalpindi Medical University, Pakistan from a period of January 2023 to August 2023...
March 2024: Curēus
https://read.qxmd.com/read/38481522/risk-of-serious-bacterial-infections-in-pediatric-patients-with-hyperpyrexia
#34
JOURNAL ARTICLE
Sofia Rachad, Dane Nickel, Fiona Berry, Meghan Goddard, Ayesha Khan, Natalie Muratori, Saul Hymes, Ashar Ata, Christopher Woll
OBJECTIVES: Hyperpyrexia has been associated with a greater prevalence of bacterial infections in the pediatric population, which prior to routine childhood vaccinations, has led to invasive testing and empiric antibiotic use for urinary tract infections, bacterial pneumonia, bacteremia, and bacterial meningitis. Since the implementation of routine childhood vaccinations, the prevalence of serious bacterial infections (SBIs) has declined. This study aims to determine if there is an association between hyperpyrexia and serious bacterial infections in well-appearing febrile pediatric patients presenting to the emergency department (ED)...
April 2024: Journal of the American College of Emergency Physicians open
https://read.qxmd.com/read/38481427/evaluation-of-three-cytomegalovirus-igg-lateral-flow-assays-for-rapid-determination-of-cmv-serostatus
#35
JOURNAL ARTICLE
Laurel Joncas-Schronce, Fatima Ali, Gregory Pepper, Renee D Stapleton, Gordon D Rubenfeld, Michael Boeckh, Ajit P Limaye
BACKGROUND: Cytomegalovirus (CMV) serostatus is a major determinant of CMV infection, disease risk, and transplant outcomes. Current clinical serology assays are limited by relatively slow turnaround time, design for batched testing, need for trained personnel, and/or specialized equipment. Rapid diagnostic assays in development have a role in emerging settings, such as critically ill patients, but have not been systematically evaluated. METHODS: We assessed the performance of 3 rapid lateral flow assays (LFAs) for the detection of CMV immunoglobulin (Ig)G antibodies compared with a reference commercially available CMV IgG enzyme-linked immunosorbent assay in residual serum samples from 200 consecutive adults who underwent clinical CMV serology testing...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38480052/the-overlooked-factor-the-impact-of-disability-on-postoperative-complications-after-emergency-general-surgery-procedures
#36
JOURNAL ARTICLE
Wardah Rafaqat, Emanuele Lagazzi, May Abiad, Dias Argandykov, Jefferson A Proaño-Zamudio, Elaine P X Van Ee, George C Velmahos, John O Hwabejire, Haytham M A Kaafarani, Michael P DeWane
BACKGROUND: Despite more than 61 million people in the United States living with a disability, studies on the impact of disability on health care disparities in surgical patients remain limited. Therefore, we aimed to understand the impact of disability on postoperative outcomes. METHODS: We performed a retrospective cohort study using the Nationwide Readmission Database (2019). We compared patients ≥18 years undergoing emergency general surgery procedures with a disability condition with those without a disability...
March 12, 2024: Surgery
https://read.qxmd.com/read/38479589/identification-of-the-murine-osteoblastic-cell-mc3t3-e1-as-a-permissive-cell-line-in-response-to-lumpy-skin-disease-virus
#37
JOURNAL ARTICLE
Ting You, Meng Wang, Hongqiang Zhang, Xiangwei Wang, Xiaolong Gao, Xiangping Yin, Yuefeng Sun, Guirong Wang, Hao-Tai Chen, Shanhui Ren
Lumpy skin disease virus (LSDV) is a rapidly emerging pathogen in China. Screening suitable cells for LSDV replication is vital for future research on pathogenic mechanisms and vaccine development. Previous comparative studies have identified that the rodent-derived BHK21 is a highly susceptible cell model to LSDV infection. Using western blot, indirect immune-fluorescence assay, flow cytometry, and transmission electron microscopy methods, this study is the first to identify the murine osteoblastic cell line MC3T3-E1 as a novel permissive cell model for LSDV infection...
March 12, 2024: Journal of Virological Methods
https://read.qxmd.com/read/38479523/wastewater-sequencing-as-a-powerful-tool-to-reveal-sars-cov-2-variant-introduction-and-spread-in-french-guiana-south-america
#38
JOURNAL ARTICLE
Marine Combe, Emira Cherif, Théo Deremarque, Georgina Rivera-Ingraham, Fatou Seck-Thiam, Fabienne Justy, Jean-Claude Doudou, Jean-François Carod, Thierry Carage, Angélique Procureur, Rodolphe Elie Gozlan
The origin of introduction of a new pathogen in a country, the evolutionary dynamics of an epidemic within a country, and the role of cross-border areas on pathogen dynamics remain complex to disentangle and are often poorly understood. For instance, cross-border areas represent the ideal location for the sharing of viral variants between countries, with international air travel, land travel and waterways playing an important role in the cross-border spread of infectious diseases. Unfortunately, monitoring the point of entry and the evolutionary dynamics of viruses in space and time within local populations remain challenging...
March 11, 2024: Science of the Total Environment
https://read.qxmd.com/read/38479444/inhalable-porous-particles-as-dual-micro-nano-carriers-demonstrating-efficient-lung-drug-delivery-for-treatment-of-tuberculosis
#39
JOURNAL ARTICLE
Jesús E Campos Pacheco, Tetiana Yalovenko, Azra Riaz, Nikolay Kotov, Camilla Davids, Alva Persson, Peter Falkman, Adam Feiler, Gabriela Godaly, C Magnus Johnson, Mikael Ekström, Georgia A Pilkington, Sabrina Valetti
Inhalation therapy treating severe infectious disease is among the more complex and emerging topics in controlled drug release. Micron-sized carriers are needed to deposit drugs into the lower airways, while nano-sized carriers are of preference for cell targeting. Here, we present a novel and versatile strategy using micron-sized spherical particles with an excellent aerodynamic profile that dissolve in the lung fluid to ultimately generate nanoparticles enabling to enhance both extra- and intra-cellular drug delivery (i...
March 11, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38479105/trimethoprim-sulfonamide-a-valid-antimicrobial-treatment-in-foals
#40
JOURNAL ARTICLE
Kajsa Gustafsson, Benjamin W Sykes, Denis Verwilghen, Katrien Palmers, Stacey Sullivan, Gaby van Galen
Trimethoprim-sulfonamide (TMPS) combinations are widely used to treat a range of infectious diseases in horses, but some equine practitioners are reluctant to use them for treatment of both neonatal and older foals. Considering the emergence of increased antimicrobial resistance, the use of protected antimicrobials commonly prescribed to foals should be avoided and alternative first-line therapy considered, where appropriate. This review examines the characteristics and pharmacokinetics of TMPS and its suitability for treatment of foals...
March 13, 2024: Journal of the American Veterinary Medical Association
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