keyword
https://read.qxmd.com/read/38493383/advances-in-skin-on-a-chip-technologies-for-dermatological-disease-modeling
#1
REVIEW
Seo Won Cho, Hamza Malick, Soo Jung Kim, Alessandro Grattoni
Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including infectious diseases, autoimmune skin conditions, wound healing, drug toxicity, aging, and antiaging, SoC aims to circumvent the inherent disparities created by traditional models...
March 15, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38493375/coronavirus-disease-2019-infections-among-emergency-health-care-personnel-impact-on-delivery-of-united-states-emergency-medical-care-2020
#2
JOURNAL ARTICLE
Kurt D Weber, William Mower, Anusha Krishnadasan, Nicholas M Mohr, Juan Carlos Montoy, Robert M Rodriguez, Philip A Giordano, Patrick Ten Eyck, Karisa K Harland, Kelli Wallace, Lawrence Clifford McDonald, Preeta K Kutty, Elisabeth M Hesse, David A Talan
STUDY OBJECTIVE: In the early months of the coronavirus disease 2019 (COVID-19) pandemic and before vaccine availability, there were concerns that infected emergency department (ED) health care personnel could present a threat to the delivery of emergency medical care. We examined how the pandemic affected staffing levels and whether COVID-19 positive staff were potentially infectious at work in a cohort of US ED health care personnel in 2020. METHODS: The COVID-19 Evaluation of Risks in Emergency Departments (Project COVERED) project was a multicenter prospective cohort study of US ED health care personnel conducted from May to December 2020...
March 16, 2024: Annals of Emergency Medicine
https://read.qxmd.com/read/38492802/significantly-reduced-duration-of-antibiotic-prescription-for-erysipelas-subsequent-to-the-2019-french-guidelines-on-skin-and-soft-tissue-infection-a-before-after-study
#3
JOURNAL ARTICLE
Justin Destoop, Clélia Vanhaecke, Firouzé Bani-Sadr, Yohan N'Guyen, Yannick Plenier, Manuelle-Anne Viguier, Maxime Hentzien
BACKGROUND: New skin and soft tissue infections (SSTI) guidelines were published in 2019 in France, changing the recommended duration for antibiotic treatment. The objective of the present study was to assess the impact of the publication of the 2019 French guidelines on SSTIs on the duration of antibiotic prescription for erysipelas. METHODS: In a before-after study (a year before and a year after April 1st, 2019), we included all adult patients diagnosed with erysipelas in Reims University Hospital medical wards and the emergency department...
March 14, 2024: Infectious diseases now
https://read.qxmd.com/read/38492519/new-perspective-of-small-molecule-antiviral-drugs-development-for-rna-viruses
#4
REVIEW
Shasha Li, Huixia Li, Ruiya Lian, Jingying Xie, Ruofei Feng
High variability and adaptability of RNA viruses allows them to spread between humans and animals, causing large-scale infectious diseases which seriously threat human and animal health and social development. At present, AIDS, viral hepatitis and other viral diseases with high incidence and low cure rate are still spreading around the world. The outbreaks of Ebola, Zika, dengue and in particular of the global pandemic of COVID-19 have presented serious challenges to the global public health system. The development of highly effective and broad-spectrum antiviral drugs is a substantial and urgent research subject to deal with the current RNA virus infection and the possible new viral infections in the future...
March 7, 2024: Virology
https://read.qxmd.com/read/38491842/group-3-innate-lymphoid-cells-a-trained-gutkeeper
#5
REVIEW
Nicolas Serafini, James P Di Santo
Group 3 innate lymphoid cells (ILC3s) are tissue-resident immune lymphocytes that critically regulate intestinal homeostasis, organogenesis, and immunity. ILC3s possess the capacity to "sense" the inflammatory environment within tissues, especially in the context of pathogen challenges that imprints durable non-antigen-specific changes in ILC3 function. As such, ILC3s become a new actor in the emerging field of trained innate immunity. Here, we summarize recent discoveries regarding ILC3 responses to bacterial challenges and the role these encounters play in triggering trained innate immunity...
March 16, 2024: Immunological Reviews
https://read.qxmd.com/read/38491456/rare-case-of-septic-shock-combined-with-meningitis-caused-by-pasteurella-multocida-without-a-history-of-cat-and-dog-bites
#6
JOURNAL ARTICLE
Yijun Zhu, Fang Zhu, Xiaoyun Shan, Jingchao Shi
BACKGROUND: Pasteurella multocida is a zoonotic pathogen that mainly causes local skin and soft tissue infections in the human body through cat and dog bites. It rarely causes bacteraemia (or sepsis) and meningitis. We reported a case of septic shock and meningitis caused by P. multocida in a patient without a history of cat and dog bites. CASE PRESENTATION: An 84-year-old male patient was urgently sent to the emergency department after he was found with unclear consciousness for 8 h, accompanied by limb tremors and urinary incontinence...
March 15, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38491425/circulating-vaccine-derived-polio-virus-type-2-outbreak-and-response-in-yemen-2021-2022-a-retrospective-descriptive-analysis
#7
JOURNAL ARTICLE
Mutahar Ahmed Al-Qassimi, Mohammed Al Amad, Ahmed Al-Dar, Ehab Al Sakaf, Ahmed Al Hadad, Yahia Ahmed Raja'a
BACKGROUND: The outbreaks of circulating Vaccine Derived Polio Viruses (cVDPVs) have emerged as a major challenge for the final stage of polio eradication. In Yemen, an explosive outbreak of cVDPV2 was reported from August 2021 to December 2022. This study aims to compare the patterns of cVDPV2 outbreak, response measures taken by health authorities, and impacts in southern and northern governorates. METHOD: A retrospective descriptive study of confirmed cases of VDPV2 was performed...
March 15, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38491115/a-novel-hantavirus-identified-in-bats-carollia-perspicillata-in-brazil
#8
JOURNAL ARTICLE
Mike Barbosa Dos Santos, Nádia Koide Albuquerque, Sandro Patroca da Silva, Fábio Silva da Silva, Daniel Damous Dias, Samira Brito Mendes, Taciana Fernandes Souza Barbosa Coelho, Maria Claudene Barros, Ana Cecília Ribeiro Cruz
Bats play an essential role in maintaining ecosystems. Their unique characteristics increase the likelihood of interactions with various species, making them a potential source for the emergence and spread of infectious diseases. Hantaviruses are continuously expanding their range of hosts. This study presents the identification of a partial genome associated with Hantavirus in samples collected from neotropical bats. We conducted a metagenomic study using samples from Carollia perspicillata in Maranhão, Brazil...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490660/multicentre-randomised-double-blind-placebo-controlled-proof-of-concept-study-of-lsalt-peptide-as-prevention-of-acute-respiratory-distress-syndrome-and-acute-kidney-injury-in-patients-infected-with-sars-cov-2-covid-19
#9
JOURNAL ARTICLE
Ranjani Somayaji, David R Luke, Arthur Lau, Rahmet Guner, Ŏ Fehmi Tabak, Mark Hepokoski, Nancy Gardetto, Steven A Conrad, Sunil D Kumar, Kalyan Ghosh, Stephen M Robbins, Donna L Senger, Daisy Sun, Rachel K S Lim, Jonathan Liu, Fatma Eser, Ridvan Karaali, Alain Tremblay, Daniel Muruve
OBJECTIVE: Dipeptidase-1 (DPEP-1) is a recently discovered leucocyte adhesion receptor for neutrophils and monocytes in the lungs and kidneys and serves as a potential therapeutic target to attenuate inflammation in moderate-to-severe COVID-19. We aimed to evaluate the safety and efficacy of the DPEP-1 inhibitor, LSALT peptide, to prevent specific organ dysfunction in patients hospitalised with COVID-19. DESIGN: Phase 2a randomised, placebo-controlled, double-blinded, trial...
March 15, 2024: BMJ Open
https://read.qxmd.com/read/38490573/the-antimicrobial-activity-of-innate-host-directed-therapies-a-systematic-review
#10
REVIEW
Tirosh Shapira, Matt Christofferson, Yossef Av-Gay
Intracellular human pathogens are the deadliest infectious diseases and pose great difficulty to effectively treat due to their protection inside the host cell and the development of antimicrobial resistance (AMR). An emerging approach to combat these intracellular pathogens is host-directed therapies (HDT), which harnesses the innate immunity of host cells. HDT relies on small molecules to promote host protection mechanisms that ultimately leads to pathogen clearance. These therapies are hypothesized to 1) possess indirect yet broad, cross species antimicrobial activity, 2) effectively target drug-resistant pathogens, 3) carry a reduced susceptibility to the development of AMR, and 4) have synergistic action with conventional antimicrobials...
March 13, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38490287/study-on-the-therapeutic-mechanism-of-hj-granules-in-a-rat-model-of-urinary-tract-infection-caused-by-escherichia-coli
#11
JOURNAL ARTICLE
Shan Cao, Shuangrong Gao, Chen Ni, Yingli Xu, Bo Pang, Jingsheng Zhang, Yu Zhang, Yaxin Wang, Zihan Geng, Shurang Li, Ronghua Zhao, Bing Han, Xiaolan Cui, Yanyan Bao
ETHNOPHARMACOLOGICAL RELEVANCE: Urinary tract infections (UTIs) are globally prevalent infectious diseases, predominantly caused by uropathogenic Escherichia coli (UPEC). The misuse of antibiotics has led to the emergence of several drug-resistant strains. Traditional Chinese Medicine (TCM) has its own advantages in the treatment of UTIs. HJ granules is a herbal formula used for the treatment of UTIs. However, its mechanism of action is not clear. AIM OF THE STUDY: The aim of this study was to investigate the therapeutic efficacy and mechanism of action of HJ granules in a rat model of UTI caused by Escherichia coli (E coli) CFT073...
March 13, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38490109/neutrophils-an-emerging-new-therapeutic-platform
#12
REVIEW
Alejandra López-Arredondo, José A Cruz-Cardenas, Jorge A Cázares-Preciado, Nicholas E Timmins, Marion Eg Brunck
Neutrophils possess unique characteristics that render them indispensable to health, and patients with irregular neutrophil counts or functions suffer from increased morbidity and mortality. As neutrophils are short-lived postmitotic cells, genetic aberrations cannot be corrected directly in neutrophils and must be targeted in their progenitors. Neutrophils are increasingly being contemplated for a range of therapeutic applications, including restoration or modulation of immune function and targeting of solid tumors...
March 13, 2024: Current Opinion in Biotechnology
https://read.qxmd.com/read/38489475/a-comparative-analysis-of-the-antibacterial-spectrum-of-ultrasmall-manganese-ferrite-nanozymes-with-varied-surface-modifications
#13
JOURNAL ARTICLE
Junhua Han, Yingxian Chen, Xin Xiang, Tingting Wang, Jianzhong Shen, Nan Zhang, Chen Liang, Xiaoli Liu, Xiaowei Ma
Bacterial infectious diseases pose a significant global challenge. However, conventional antibacterial agents exhibit limited therapeutic effectiveness due to the emergence of drug resistance, necessitating the exploration of novel antibacterial strategies. Nanozymes have emerged as a highly promising alternative to antibiotics, owing to their particular catalytic activities against pathogens. Herein, we synthesized ultrasmall-sized MnFe2 O4 nanozymes with different charges (MnFe2 O4 -COOH, MnFe2 O4 -PEG, MnFe2 O4 -NH2 ) and assessed their antibacterial capabilities...
March 15, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38487535/understanding-covid-19-associated-endothelial-dysfunction-role-of-piezo1-as-a-potential-therapeutic-target
#14
REVIEW
Xiaoting Zhang, Jinhai Liu, Xiaoming Deng, Lulong Bo
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Due to its high infectivity, the pandemic has rapidly spread and become a global health crisis. Emerging evidence indicates that endothelial dysfunction may play a central role in the multiorgan injuries associated with COVID-19. Therefore, there is an urgent need to discover and validate novel therapeutic strategies targeting endothelial cells. PIEZO1, a mechanosensitive (MS) ion channel highly expressed in the blood vessels of various tissues, has garnered increasing attention for its potential involvement in the regulation of inflammation, thrombosis, and endothelial integrity...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38487193/patients-response-during-the-co-circulation-of-multiple-respiratory-diseases-in-china-based-on-the-self-regulation-common-sense-model
#15
JOURNAL ARTICLE
Shanwen Sun, Yali Wang, Hailong Hou, Yuqi Niu, Yefan Shao, Linlin Chen, Xiaochun Zhang
BACKGROUND: Following the COVID-19 pandemic, another large-scale respiratory epidemic has emerged in China, causing significant social impact and disruption. The article is to explore the patients' psychological and behavioral responses to the enhancement of healthcare quality. METHODS: Based on the five dimensions of the Self-Regulation Common-Sense Model, we developed an interview outline to explore the process by which patients identify disease symptoms to guide action plans and coping strategies...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38486815/attributable-cost-of-adult-respiratory-syncytial-virus-illness-beyond-the-acute-phase
#16
JOURNAL ARTICLE
Ahuva Averin, Mark Atwood, Reiko Sato, Kari Yacisin, Elizabeth Begier, Kimberly Shea, Daniel Curcio, Linnea Houde, Derek Weycker
BACKGROUND: Estimates of the cost of medically attended lower respiratory tract illness (LRTI) due to respiratory syncytial virus (RSV) in adults, especially beyond the acute phase, is limited. This study was undertaken to estimate the attributable costs of RSV-LRTI among US adults during, and up to 1 year after, the acute phase of illness. METHODS: A retrospective observational matched-cohort design and a US healthcare claims repository (2016-2019) were employed...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38486662/quality-availability-and-suitability-of-antimicrobial-stewardship-guidance-a-multinational-qualitative-study
#17
JOURNAL ARTICLE
Zane Linde-Ozola, Annika Y Classen, Christian G Giske, Siri Göpel, Noa Eliakim-Raz, Makeda Semret, Gunnar Skov Simonsen, Jörg Janne Vehreschild, Silje Bakken Jørgensen, Johanna Kessel, Lars Kåre Selland Kleppe, Dorthea Hagen Oma, Maria J G T Vehreschild, Aija Vilde, Uga Dumpis
BACKGROUND: Antimicrobial stewardship (AMS) programmes are established across the world to treat infections efficiently, prioritize patient safety, and reduce the emergence of antimicrobial resistance. One of the core elements of AMS programmes is guidance to support and direct physicians in making efficient, safe and optimal decisions when prescribing antibiotics. To optimize and tailor AMS, we need a better understanding of prescribing physicians' experience with AMS guidance. OBJECTIVES: To explore the prescribing physicians' user experience, needs and targeted improvements of AMS guidance in hospital settings...
April 2024: JAC-antimicrobial resistance
https://read.qxmd.com/read/38486340/climate-influenced-vector-borne-diseases-in-africa-a-call-to-empower-the-next-generation-of-african-researchers-for-sustainable-solutions
#18
JOURNAL ARTICLE
Judicaël Obame-Nkoghe, Adjoavi Esse Agossou, Gerald Mboowa, Basile Kamgang, Cyril Caminade, Dawn C Duke, Andrew Karanja Githeko, Obed M Ogega, Nestor Engone Elloué, Fatou Bintou Sarr, Dieudonné Nkoghe, Pierre Kengne, Nicaise T Ndam, Christophe Paupy, Moses Bockarie, Patricks Voua Otomo
We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges...
March 14, 2024: Infectious Diseases of Poverty
https://read.qxmd.com/read/38486152/isolation-and-characterization-of-lytic-bacteriophages-from-various-sources-in-addis-ababa-against-antimicrobial-resistant-diarrheagenic-escherichia-coli-strains-and-evaluation-of-their-therapeutic-potential
#19
JOURNAL ARTICLE
Tamirat Salile Sada, Tesfaye Sisay Tessema
BACKGROUND: Escherichia coli is a common fecal coliform, facultative aerobic, gram-negative bacterium. Pathogenic strains of such microbes have evolved to cause diarrhea, urinary tract infections, and septicemias. The emergence of antibiotic resistance urged the identification of an alternative strategy. The use of lytic bacteriophages against the control of pathogenic E. coli in clinics and different environmental setups (waste and drink water management) has become an alternative therapy to antibiotic therapy...
March 14, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38484348/pulmonary-abscess-with-atypical-topography-computed-tomography-assessment-before-and-after-treatment
#20
JOURNAL ARTICLE
Cristina Asvolinsque Pantaleão Fontes, Mary Lúcia Bedran Ananias, Juliana Garcia Alves da Trindade
INTRODUCTION: We present a clinical case of a patient with neurological sequelae, dementia, gastrostomy and tracheostomy with a metal canula, who developed a lung abscess in an atypical topography, in the anterior segment of the left upper lobe, being attended to in the emergency department. CASE PRESENTATION: A 79-year-old man who was bedridden and with neurological sequelae resulting from a hemorrhagic stroke, with gastrostomy and tracheostomy with a metal canula, was attended for daily fever and increased secretion trough the canula, and a diagnosis of bronchoaspiration pneumonia was made...
February 29, 2024: Journal of Infection in Developing Countries
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