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Ismail Elahabadi, Amir Rahnama, Gholamreza Bazmandegan, Zahra Kamiab
The aim of this study was to introduce a patient with mucinous nonneoplastic cyst (MNNC) at an unusual age. MNNCs of the pancreas are uncommon primary tumors, which affect middle-aged women in their fifth decade of life and have significant malignant potential. Therefore, it is important to accurately diagnose and remove them. This case is a 28-year-old woman patient who presented with a pain in the right and upper abdomen from 3 months ago and worsened at night. A cystic lesion was observed near the upper bridge of the left kidney in abdominal ultrasonography...
November 2023: Journal of Surgical Case Reports
#22
JOURNAL ARTICLE
Se Jin Choi, Sung Joo Kim, Dong Wook Kim, Seung Soo Lee, Seung-Mo Hong, Kyung Won Kim, Jin Hee Kim, Hyoung Jung Kim, Jae Ho Byun
OBJECTIVE: To investigate the imaging characteristics of large duct pancreatic ductal adenocarcinoma (LD-PDAC) on computed tomography (CT) and magnetic resonance imaging (MRI). MATERIALS AND METHODS: Thirty-five patients with LD-PDAC (63.2 ± 9.7 years) were retrospectively evaluated. Tumor morphology on CT and MRI (predominantly solid mass vs. solid mass with prominent cysts vs. predominantly cystic mass) was evaluated. Additionally, the visibility, quantity, shape (oval vs...
December 2023: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
#23
JOURNAL ARTICLE
Teppei Yoshioka, Minoru Shigekawa, Kenji Ikezawa, Motohiro Hirao, Shuji Ishii, Takahiro Suda, Tadashi Kegasawa, Kengo Matsumoto, Kiyoshi Iwahashi, Jun Murata, Akira Kaneko, Shoichi Nakazuru, Shuhei Yamamoto, Takayuki Matsumae, Kazuhiro Kozumi, Yu Sato, Junya Okabe, Katsuhiko Sato, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
BACKGROUND: Intraductal papillary mucinous neoplasia (IPMN) is a risk factor for pancreatic cancer (PC). PC concomitant with IPMN shows rapid progression similar to de novo PC, therefore, the appropriate observation interval (OI) is not yet clear. PATIENTS AND METHOD: This was a multicenter retrospective observational study, and patients with PC concomitant with IPMN were analyzed. OI was defined as the interval between the date of imaging at PC diagnosis and just before the diagnosis...
November 18, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
#24
JOURNAL ARTICLE
Lidan Wang, Ling Zhu
RATIONALE: Pancreas mucinous cystic neoplasm (PMCN) is uncommon, and its occurrence during pregnancy is rare. The management of PMCN during pregnancy, including diagnosis and surgical timing, is a great challenge. PATIENT CONCERNS: A nontender epigastric mass of the upper abdomen was detected by palpation in a 35-year-old woman, gravida 2, para 1, during the 36th week of gestation. She was referred to our institution for further evaluation. DIAGNOSES: Magnetic resonance imaging (MRI) showed a multilocular cystic mass in the body and tail of the pancreas (16...
November 17, 2023: Medicine (Baltimore)
#25
JOURNAL ARTICLE
Peiyun Ni, Harrison Mayo, Carlos Fernández-Del Castillo, Sami Elamin, Douglas R Brown, Mari Mino-Kenudson, Kumar Krishnan, Brenna Casey, Kelly Lafaro, Anne Marie Lennon, Elham Afghani, Yasmin G Hernandez-Barco
BACKGROUND: Main-duct (MD-) and mixed-type (MT-) IPMNs harbor an increased risk of pancreatic cancer and warrant surgical resection. Preoperative endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) are important in the diagnosis of IPMNs. The aim of this study was to investigate whether endoscopic procedures manipulating the MD impact postoperative adverse events in patients with MD- and MT-IPMNs. METHODS: We performed a retrospective study of 369 patients who underwent resections for MD- or MT-IPMN at two tertiary centers (2000-2019)...
November 14, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
#26
JOURNAL ARTICLE
Márton Benke, Anikó Zeöld, Ágnes Kittel, Delaram Khamari, István Hritz, Miklós Horváth, Bánk Keczer, Katalin Borka, Ákos Szücs, Zoltán Wiener
Extracellular vesicles (EV) carry their cargo in a membrane protected form, however, their value in early diagnostics is not well known. Although pancreatic cysts are heterogeneous, they can be clustered into the larger groups of pseudocysts (PC), and serous and mucinous pancreatic cystic neoplasms (S-PCN and M-PCN, respectively). In contrast to PCs and S-PCNs, M-PCNs may progress to malignant pancreatic cancers. Since current diagnostic tools do not meet the criteria of high sensitivity and specificity, novel methods are urgently needed to differentiate M-PCNs from other cysts...
November 14, 2023: Scientific Reports
#27
JOURNAL ARTICLE
Amr Alnagar, Omer Khamag, Khalid Sharif, Darius F Mirza, Evelyn G P Ong
BACKGROUND: Paediatric pancreatic pathology and its management is rarely described. We present our experience. METHODS: A retrospective case-note review of all patients with pancreatic disease from 1995 to 2021 was completed. Data are quoted as median (range). RESULTS: Two hundred and twelve patients were identified with 75.9% presenting with pancreatitis. Referrals for pancreatitis increased during the study period and affected a wide age range (2 months-15...
October 21, 2023: Journal of Pediatric Surgery
#28
JOURNAL ARTICLE
Stuart Astbury, Aishwarya Baskar, Jane I Grove, Philip Kaye, Aloysious D Aravinthan, Martin W James, Christopher Clarke, Guruprasad P Aithal, Suresh Vasan Venkatachalapathy
Background and study aims Pancreatic cysts are common incidental findings, with an estimated prevalence of 13% to 15% in imaging done for other reasons. Diagnosis often relies on collection of cyst fluid, but tissue sampling using micro-forceps may allow for a more reliable diagnosis and higher yield of DNA for next-generation sequencing (NGS). The primary aim was to assess the performance of NGS in identifying mucinous cyst. The secondary aims were to assess DNA yield between the cyst fluid and cyst wall tissue, complication rate and performance of conventional investigations...
October 2023: Endoscopy International Open
#29
JOURNAL ARTICLE
David Kim, Elizabeth Margolskee, Abha Goyal, Momin T Siddiqui, Jonas J Heymann, Rema Rao, Joshua Hayden
AIM: Pancreatic cyst fluid carcinoembryonic antigen (CEA) is a pivotal test in the diagnosis and management of neoplastic mucinous cysts (NMC) of the pancreas. Cyst fluid CEA levels of 192 ng/mL have been widely used to identify NMC. However, CEA values are unique to and significantly differ between individual assays with various optimal cutoffs reported in the literature for NMC. Here, we investigate the optimal CEA cut-off value of pancreatic cysts from two different assays to identify differences in thresholds...
November 8, 2023: Journal of Clinical Pathology
#30
JOURNAL ARTICLE
Felix Hesse, Jessica Ritter, Alexander Hapfelmeier, Rickmer Braren, Veit Phillip
OBJECTIVES: Because IPMNs are potentially malignant, surveillance of IPMN is recommended by magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS). The aim of the study was the evaluation of the concordance between EUS and MRI regarding cyst size. METHODS: Retrospective data analysis was done for patients with IPMN in whom EUS and MRI were performed simultaneously (≤60 days). The measured cyst size of both procedures was compared by Bland-Altman plots...
November 1, 2023: Pancreas
#31
JOURNAL ARTICLE
Shunta Tanaka, Masahiro Tsujimae, Atsuhiro Masuda, Jun Inoue, Noriko Inomata, Hisahiro Uemura, Shinya Kohashi, Kae Nagao, Shigeto Masuda, Shohei Abe, Masanori Gonda, Kohei Yamakawa, Shigeto Ashina, Ryota Nakano, Takeshi Tanaka, Yasutaka Yamada, Arata Sakai, Takashi Kobayashi, Hideyuki Shiomi, Koichi Fujita, Takahiro Anami, Tsuyoshi Fujita, Akihiko Watanabe, Yuzo Kodama
OBJECTIVES: Aging is associated with a high prevalence of pancreatic cysts and intraductal papillary mucinous neoplasms (IPMNs). Metabolic syndrome (MS) may increase the risk of neoplasms, including those that develop in the pancreas. However, the influence of factors associated with MS on the development of IPMN remains unclear. METHODS: A total of 9363 patients who underwent abdominal ultrasound examinations between April 2012 and May 2013 were included in this study...
October 30, 2023: Pancreas
#32
REVIEW
Marlies Vornhülz, Simon Sirtl, Elisabeth Orgler, Maximilian Weniger, Jörg Schirra, Georg Beyer, Julia Mayerle
BACKGROUND: Cystic pancreatic lesions are detected incidentally at an increasing rate. Often, the patients present asymptomatically. Hence, the resulting clinical consequences remain challenging and unsettling for both physicians and patients. OBJECTIVES: Status of current recommendations in handling cystic pancreatic lesions. MATERIALS AND METHODS: Selective literature search of PubMed while taking current guidelines into account. RESULTS: Correct diagnostic classification of the cystic lesion is crucial since further action depends on the type of cystic lesion...
October 25, 2023: Radiologie (Heidelb)
#33
JOURNAL ARTICLE
Mitsuhiro Tachibana, Takayoshi Hirota, Hideki Hamayasu, Yu Takeuchi, Kei Tsukamoto, Masahiro Matsushita
We report a case of colloid carcinoma (CC) arising from an intestinal-type intraductal papillary mucinous neoplasm with high-grade dysplasia (IPMNHGD) of the pancreas, diagnosed with serial pancreatic juice aspiration cytological examination (SPACE). A rapidly growing intraductal papillary mucinous neoplasm (IPMN) in a 71-year-old Japanese man accelerated his hospitalization in our institute. Clinically, a large, ruptured pancreatic cyst was suspected. Cytologically, several mucin-positive signet-ring cells were scattered in the inflammatory, necrotic, or mucinous background...
October 4, 2023: Diagnostics
#34
JOURNAL ARTICLE
Laura D Wood, N Volkan Adsay, Olca Basturk, Lodewijk A A Brosens, Noriyoshi Fukushima, Seung-Mo Hong, Sung-Joo Kim, Jae W Lee, Claudio Luchini, Michaël Noë, Martha B Pitman, Aldo Scarpa, Aatur D Singhi, Mariko Tanaka, Toru Furukawa
BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients. METHODS: Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN...
August 11, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
#35
JOURNAL ARTICLE
Keisuke Oyama, Yoshifumi Iwagami, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Takehiro Noda, Tadafumi Asaoka, Shin Nakahira, Kunihito Gotoh, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Pancreatic mucinous cystic neoplasm (MCN) rarely ruptures because of their surrounding fibrotic capsules and has never been reported with detailed information regarding prerupture and postrupture states. We report a case of MCN rupture where performed emergency surgery was performed while waiting for elective surgery. A 54-year-old woman was referred to our department for a pancreatic cystic tumor with slight abdominal pain. A cystic tumor with a nodular lesion was found, with a contrast effect measuring 78 mm in diameter...
February 1, 2023: Pancreas
#36
JOURNAL ARTICLE
Jasmina Kuvendjiska, Felix Müller, Peter Bronsert, Sylvia Timme-Bronsert, Stefan Fichtner-Feigl, Birte Kulemann
Intraductal papillary mucinous neoplasm (IPMN) is the most common pancreatic cyst and a precursor of pancreatic cancer (PDAC). Since PDAC has a devastatingly high mortality rate, the early diagnosis and treatment of any precursor lesion are rational. The safety of the existing guidelines on the clinical management of IPMN has been criticized due to unsatisfactory sensitivity and specificity, showing the need for further markers. Blood obtained from patients with IPMN was therefore subjected to size-based isolation of circulating epithelial cells (CECs)...
July 15, 2023: Life
#37
JOURNAL ARTICLE
Jorge D Machicado, Bertrand Napoleon, Venkata Akshintala, Ahmad Najdat Bazarbashi, Mohammad Bilal, Juan E Corral, Mohannad Dugum, Samuel Han, Farah S Hussain, Alyson M Johnson, Manol Jovani, Jennifer M Kolb, Paul Leonor, Peter J Lee, Ramzi Mulki, Hamza Shah, Harkirat Singh, Sergio A Sánchez-Luna, Shawn L Shah, Anand Singla, Eric J Vargas, Thomas Tielleman, Melica Nikahd, Megan Fry, Stacey Culp, Somashekar G Krishna
BACKGROUND AND AIMS: There are limited data about how to teach endosonographers needle-based confocal laser endomicroscopy (nCLE)-guided histologic diagnosis of pancreatic cystic lesions (PCLs). Hence, we developed and tested a structured educational program to train early-career endosonographers in nCLE-guided diagnosis of PCLs. METHODS: Twenty-one early-career nCLE-naive endosonographers watched a teaching module outlining nCLE criteria for diagnosing PCLs. Participants then reviewed 80 high-yield nCLE videos, recorded diagnoses, and received expert feedback (phase 1)...
July 18, 2023: Gastrointestinal Endoscopy
#38
Saroja Devi Geetha, Louis Kavoussi, Rebecca Thomas, Deepika Savant
Mucinous neoplasms are commonly seen in the ovaries and pancreas. Their occurrence in the retroperitoneum is uncommon. We present a case of a retroperitoneal mucinous cystadenocarcinoma in a 54-year-old female who presented with right flank pain. Imaging demonstrated an 8.6 × 7.9 cm mass at the anterior surface of the lower pole of the right kidney, suspicious for renal cell carcinoma. Serum tumor markers carbohydrate antigen 19-9 (CA 19-9) and cancer embryonic antigen (CEA) were within normal limits, and cancer antigen 125 (CA 125) was elevated...
June 2023: Curēus
#39
MULTICENTER STUDY
Giovanni Marchegiani, Tommaso Pollini, Anna Burelli, Youngmin Han, Hye-Sol Jung, Wooil Kwon, Dario Missael Rocha Castellanos, Stefano Crippa, Giulio Belfiori, Paolo Giorgio Arcidiacono, Gabriele Capurso, Laura Apadula, Piera Zaccari, José Lariño Noia, Myrte Gorris, Olivier Busch, Arachchige Ponweera, Kulbir Mann, Ihsan Ekin Demir, Veit Phillip, Nuzhat Ahmad, Thilo Hackert, Max Heckler, Anne Marie Lennon, Elham Afghani, Davide Vallicella, Tommaso Dall'Olio, Angelica Nepi, Charles M Vollmer, Helmut Friess, Paula Ghaneh, Marc Besselink, Massimo Falconi, Claudio Bassi, Brian Kim-Poh Goh, Jin-Young Jang, Carlos Fernández-Del Castillo, Roberto Salvia
BACKGROUND & AIMS: Currently, most patients with branch duct intraductal papillary mucinous neoplasms (BD-IPMN) are offered indefinite surveillance, resulting in health care costs with questionable benefits regarding cancer prevention. This study sought to identify patients in whom the risk of cancer is equivalent to an age-matched population, thereby justifying discontinuation of surveillance. METHODS: International multicenter study involving presumed BD-IPMN without worrisome features (WFs) or high-risk stigmata (HRS) at diagnosis who underwent surveillance...
October 2023: Gastroenterology
#40
JOURNAL ARTICLE
Mengjing Fan, Fang Yang
Background. Enteric duplication cysts are rare but can occur in various parts of the gastrointestinal tract, including the pancreas. Most enteric duplication cysts are benign; however, neoplastic transformation has been reported in a few cases, with adenocarcinoma being the most common malignant transformation. Case Presentation. We present an adult with a pancreatic enteric duplication cyst and low-grade mucinous neoplasm. The patient did not exhibit any clinically significant symptoms or physical signs. Imaging revealed a cystic mass in the pancreatic head...
July 2, 2023: International Journal of Surgical Pathology
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