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https://read.qxmd.com/read/38526926/the-2023-ao-spine-praxis-guidelines-in-acute-spinal-cord-injury-what-have-we-learned-what-are-the-critical-knowledge-gaps-and-barriers-to-implementation
#1
JOURNAL ARTICLE
Michael G Fehlings, Ali Moghaddamjou, Nathan Evaniew, Lindsay A Tetreault, Mohammed Ali Alvi, Andrea C Skelly, Brian K Kwon
STUDY DESIGN: Narrative summary of the 2023 AO Spine-Praxis clinical practice guidelines for management in acute spinal cord injury (SCI). OBJECTIVES: The objective of this article is to summarize the key findings of the clinical practice guidelines for the optimal management of traumatic and intraoperative SCI (ISCI). This article will also highlight potential knowledge translation opportunities for each recommendation and discuss important knowledge gaps and areas of future research...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38446594/resource-utilization-following-anterior-versus-posterior-cervical-decompression-and-fusion-for-acute-central-cord-syndrome
#2
JOURNAL ARTICLE
Jerry Y Du, Karim Shafi, Collin W Blackburn, Jens R Chapman, Nicholas U Ahn, Randall E Marcus, Todd J Albert
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: The purpose of this study is to compare the impact of anterior cervical decompression and fusion (ACDF) versus posterior cervical decompression and fusion (PCDF) for the treatment of acute traumatic central cord syndrome (CCS) on hospital episodes of care in terms of (1) cost, (2) length of hospital stay, and (3) discharge destination. SUMMARY OF BACKGROUND DATA: Acute traumatic CCS is the most common form of spinal cord injury in the United States...
March 1, 2024: Clinical Spine Surgery
https://read.qxmd.com/read/38436641/central-cord-syndrome-after-fall-from-inversion-table
#3
Isaac Michels, Lang Jacobson
INTRODUCTION: Central cord syndrome, the most common incomplete traumatic spinal cord injury, often results in functional impairment with variable recovery. CASE PRESENTATION: Central cord syndrome developed in a 64-year-old man during routine home use of an inversion table. DISCUSSION: The incidence of central cord syndrome, which occurs most frequently after a fall, is increasing among older persons. Age-related changes in the cervical spine may predispose the spinal cord to compression and injury during a fall...
February 2024: WMJ: Official Publication of the State Medical Society of Wisconsin
https://read.qxmd.com/read/38429643/single-cell-rna-sequencing-reveals-peripheral-blood-leukocyte-responses-to-spinal-cord-injury-in-mice-with-humanised-immune-systems
#4
JOURNAL ARTICLE
Ellen R Gillespie, Laura F Grice, Isabel G Courtney, Hong Wa Lao, Woncheol Jung, Sonny Ramkomuth, Jacky Xie, David A Brown, James Walsham, Kristen J Radford, Quan H Nguyen, Marc J Ruitenberg
Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cord haematopoietic stem cells to investigate how human immune cells respond to and/or are changed by traumatic spinal cord injury (SCI). We hypothesised that the use of such mice could help advance our understanding of spinal cord injury-induced immune depression syndrome (SCI-IDS), and also how human leukocytes change as they migrate from the circulation into the lesion site...
March 1, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38335527/surgical-intervention-%C3%A2-24-hours-versus-24-hours-after-injury-for-the-management-of-acute-traumatic-central-cord-syndrome-a-systematic-review-and-meta-analysis
#5
JOURNAL ARTICLE
Othman Bin-Alamer, Jumanah Qedair, Hussam Abou-Al-Shaar, Arka N Mallela, Kishore Balasubramanian, Nada Alnefaie, Abdul Rahman Abou Al-Shaar, Tritan Plute, Victor M Lu, David J McCarthy, Daryl P Fields, Nitin Agarwal, Peter C Gerszten, D Kojo Hamilton
OBJECTIVE: The objective was to evaluate the efficacy, outcomes, and complications of surgical intervention performed within 24 hours (≤ 24 hours) versus after 24 hours (> 24 hours) in managing acute traumatic central cord syndrome (ATCCS). METHODS: Articles pertinent to the study were retrieved from PubMed, Scopus, Web of Science, and Cochrane. The authors performed a systematic review and meta-analysis of treatment procedures and outcomes according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRIMSA) guidelines...
February 9, 2024: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/38322071/navigating-complexity-a-case-report-of-concurrent-central-cord-syndrome-and-stroke-in-an-elderly-gentleman
#6
Hoe Teong Kee, Mohd Hezery Bin Harun, Fadzrul Abbas Mohamed Ramlee, Teck Siang Lim, Fahrudin Che-Hamzah
Central cord syndrome (CCS) predominantly manifests in elderly individuals with pre-existing cervical spondylosis resulting from hyperextension mechanisms. However, it is not exclusive to the older population and can occur in younger individuals following traumatic cervical spine injuries or, less frequently, due to nontraumatic causes. The impact of this syndrome is more pronounced in the upper extremities, where motor function experiences greater impairment compared to sensory function. CCS presents itself along a spectrum of severity...
January 2024: Curēus
https://read.qxmd.com/read/38266996/surgical-outcomes-in-octogenarians-with-central-cord-syndrome-a-propensity-score-matched-analysis
#7
JOURNAL ARTICLE
Sam H Jiang, Daniel Deysher, Kaho Adachi, Mounika Bhaskara, Zayed Almadidy, Morteza Sadeh, Ankit I Mehta, Nauman S Chaudhry
INTRODUCTION: Central cord syndrome (CCS) is a traumatic cervical spine injury that is treated with surgical decompression. In octogenarians (80-89), surgeons often opt for conservative management instead due to fears of postoperative complications and prolonged recovery times. This study aims to assess the in-hospital complications and outcomes in octogenarians undergoing surgery compared to those undergoing non-surgical management for CCS. METHODS: The National Trauma Data Bank was queried from 2017 to 2019 for octogenarians with CCS...
January 22, 2024: World Neurosurgery
https://read.qxmd.com/read/38217620/medical-comorbidities-in-patients-with-prolonged-disorder-of-consciousness-a-narrative-review
#8
REVIEW
Anna Estraneo, Marie-Michele Briand, Enrique Noé
BACKGROUND: A few studies specifically addressed medical comorbidities (MCs) in patients with severe acquired traumatic or non-traumatic brain injury and prolonged disorders of consciousness (pDoC; i.e., patients in vegetative state/unresponsive wakefulness syndrome, VS/UWS, or in minimally conscious state, MCS). OBJECTIVE: To provide an overview on incidence of MCs in patients with pDoC. METHODS: Narrative review on most impacting MCs in patients with pDoC, both those directly related to brain damage (epilepsy, neurosurgical complications, spasticity, paroxysmal sympathetic hyperactivity, PSH), and those related to severe disability and prolonged immobility (respiratory comorbidities, endocrine disorders, metabolic abnormalities, heterotopic ossifications)...
2024: NeuroRehabilitation
https://read.qxmd.com/read/38216970/prediction-of-clinical-progression-in-nervous-system-diseases-plasma-glial-fibrillary-acidic-protein-gfap
#9
REVIEW
Xiaoxiao Zheng, Jingyao Yang, Yiwei Hou, Xinye Shi, Kangding Liu
Glial fibrillary acidic protein (GFAP), an intracellular type III intermediate filament protein, provides structural support and maintains the mechanical integrity of astrocytes. It is predominantly found in the astrocytes which are the most abundant subtypes of glial cells in the brain and spinal cord. As a marker protein of astrocytes, GFAP may exert a variety of physiological effects in neurological diseases. For example, previous published literatures showed that autoimmune GFAP astrocytopathy is an inflammatory disease of the central nervous system (CNS)...
January 12, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38197654/concomitant-traumatic-brain-injury-delays-surgery-in-patients-with-traumatic-spinal-cord-injury
#10
JOURNAL ARTICLE
Tej D Azad, Divyaansh Raj, Kathleen R Ran, Vikas N Vattipally, Anmol Warman, Micheal Raad, John R Williams, Daniel Lubelski, Elliott R Haut, Jose I Suarez, Ali Bydon, Timothy F Witham, Christopher D Witiw, Nicholas Theodore, James P Byrne
BACKGROUND AND OBJECTIVES: Growing evidence supports prompt surgical decompression for patients with traumatic spinal cord injury (tSCI). Rates of concomitant tSCI and traumatic brain injury (TBI) range from 10% to 30%. Concomitant TBI may delay tSCI diagnosis and surgical intervention. Little is known about real-world management of this common injury constellation that carries significant clinical consequences. This study aimed to quantify the impact of concomitant TBI on surgical timing in a national cohort of patients with tSCI...
January 10, 2024: Neurosurgery
https://read.qxmd.com/read/38038474/treatment-of-acute-traumatic-central-cord-syndrome-a-study-of-north-american-trauma-centers
#11
JOURNAL ARTICLE
Jetan H Badhiwala, Christopher D Witiw, Jefferson R Wilson, Leodante B da Costa, Avery B Nathens, Michael G Fehlings
BACKGROUND AND OBJECTIVES: Central cord syndrome (CCS) is expected to become the most common traumatic spinal cord injury, yet its optimal management remains unclear. This study aimed to evaluate variability in nonoperative vs operative treatment for CCS between trauma centers in the American College of Surgeons Trauma Quality Improvement Program, identify patient- and hospital-level factors associated with treatment, and determine the association of treatment with outcomes. METHODS: Adults with CCS were identified from the Trauma Quality Improvement Program database (2014-2016)...
December 1, 2023: Neurosurgery
https://read.qxmd.com/read/37890727/early-vs-late-surgical-decompression-for-patients-with-acute-traumatic-central-cord-syndrome-a-systematic-review-and-meta-analysis
#12
REVIEW
Shahab Aldin Sattari, Albert Antar, John N Theodore, Andrew M Hersh, Abdel-Hameed Al-Mistarehi, A Daniel Davidar, Carly Weber-Levine, Tej D Azad, Wuyang Yang, James Feghali, Risheng Xu, Amir Manbachi, Daniel Lubelski, Chetan Bettegowda, Louis Chang, Timothy Witham, Allan Belzberg, Nicholas Theodore
BACKGROUND CONTEXT: The optimal decompression time for patients presenting with acute traumatic central cord syndrome (ATCCS) has been debated, and a high level of evidence is lacking. PURPOSE: To compare early (<24 hours) versus late (≥24 hours) surgical decompression for ATCCS. STUDY DESIGN: Systematic review and meta-analysis. METHODS: Medline, PubMed, Embase, and CENTRAL were searched from inception to March 15th, 2023...
October 25, 2023: Spine Journal: Official Journal of the North American Spine Society
https://read.qxmd.com/read/37789891/posterior-spinal-decompression-in-adults-with-spinal-cord-injury-without-traumatic-compromise-of-the-spinal-canal-what-is-the-data
#13
REVIEW
Mary Solou, Anastasios A Politis, Ιoannis Ydreos, Evangelos K Papadopoulos, Stamatios Banos, Georgios Savvanis, Maria M Gavra, Efstathios J Boviatsis, Lampis C Stavrinou
BACKGROUND: Spinal cord injury (SCI) can be caused by a variety of factors and its severity can range from a mild concussion to a complete severing of the spinal cord. Τreatment depends on the type and severity of injury, the patient's age and overall health. Reduction of dislocated or fractured vertebrae via closed manipulation or surgical procedures, fixation and removal of bony fragments and debris that compromise the spinal canal are indicated for decompression of the spinal cord and stabilization of the spine...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37771121/benefits-of-early-surgical-treatment-for-patients-with-multilevel-cervical-canal-stenosis-of-acute-traumatic-central-cord-syndrome
#14
JOURNAL ARTICLE
Quan Zhou, Wei He, Jiaheng Lv, Hao Liu, Huilin Yang, Junxin Zhang, Tao Liu
INTRODUCTION: Currently, there exists considerable debate surrounding the optimal treatment approaches for different subtypes of patients with spinal cord injury (SCI). The purpose of this study was to conduct a comparative analysis of the benefits associated with conservative treatment and treatments with different surgical periods for patients diagnosed with acute traumatic central cord syndrome (ATCCS) and multilevel cervical canal stenosis (CCS). METHODS: A retrospective cohort study was conducted, and 93 patients who met inclusion and exclusion criteria in our hospital between 2015 and 2020 were followed for a minimum duration of 2 years...
September 28, 2023: Orthopaedic Surgery
https://read.qxmd.com/read/37638460/the-importance-of-screening-for-functional-neurological-disorders-in-patients-with-persistent-post-concussion-symptoms
#15
JOURNAL ARTICLE
Kaiden Jobin, Meng Wang, Sané du Plessis, Noah D Silverberg, Chantel T Debert
BACKGROUND: Functional neurological disorder (FND) may commonly co-occur with persistent symptoms following a psychological trauma or physical injury such as concussion. OBJECTIVE: To explore the occurrence of FND in a population with persistent post-concussion symptoms (PPCS) and the associations between FND and depression as well as anxiety in participants with PPCS. METHODS: Sixty-three individuals with PPCS presenting to a specialized brain injury clinic completed the following questionnaires: screening for somatoform disorder conversion disorder subscale (SOM-CD), Rivermead post-concussion symptom questionnaire (RPQ), patient health questionnaire-9 (PHQ-9), and generalized anxiety disorder questionnaire- 7 (GAD-7)...
2023: NeuroRehabilitation
https://read.qxmd.com/read/37524347/five-year-mortality-after-traumatic-central-cord-syndrome-in-wales
#16
JOURNAL ARTICLE
Alexandra L Stanley, Tyler J Jones, Davor Dasic, Siva Kakarla, Sridhar Kolli, Swaroop Shanbhag, Michael J H McCarthy
AIMS: Traumatic central cord syndrome (CCS) typically follows a hyperextension injury and results in motor impairment affecting the upper limbs more than the lower, with occasional sensory impairment and urinary retention. Current evidence on mortality and long-term outcomes is limited. The primary aim of this study was to assess the five-year mortality of CCS, and to determine any difference in mortality between management groups or age. METHODS: Patients aged ≥ 18 years with a traumatic CCS between January 2012 and December 2017 in Wales were identified...
August 1, 2023: Bone & Joint Journal
https://read.qxmd.com/read/37468659/early-surgical-intervention-for-acute-spinal-cord-injury-time-is-spine
#17
REVIEW
Ayesha Quddusi, Karlo M Pedro, Mohammed Ali Alvi, Nader Hejrati, Michael G Fehlings
Acute traumatic spinal cord injury (tSCI) is a devastating occurrence that significantly contributes to global morbidity and mortality. Surgical decompression with stabilization is the most effective way to minimize the damaging sequelae that follow acute tSCI. In recent years, strong evidence has emerged that supports the rationale that early surgical intervention, within 24 h following the initial injury, is associated with a better prognosis and functional outcomes. In this review, we have summarized the evidence and elaborated on the nuances of this concept...
July 19, 2023: Acta Neurochirurgica
https://read.qxmd.com/read/37449640/a-novel-mouse-model-of-central-cord-syndrome
#18
JOURNAL ARTICLE
Elzat Elham-Yilizati Yilihamu, Xiangchuang Fan, Zimeng Yang, Shiqing Feng
Patients with potential spinal stenosis are susceptible to central cord syndrome induced by blunt trauma. Suitable animal models are helpful for studying the pathogenesis and treatment of such injuries. In this study, we established a mouse model of acute blunt traumatic spinal cord injury by compressing the C6 spinal cord with 5 and 10 g/mm2 compression weights to simulate cervical central cord syndrome. Behavioral testing confirmed that this model exhibited the characteristics of central cord syndrome because motor function in the front paws was impaired, whereas basic motor and sensory functions of the lower extremities were retained...
December 2023: Neural Regeneration Research
https://read.qxmd.com/read/37425570/horner-syndrome-after-anterior-cervical-spine-surgery-for-traumatic-spinal-cord-injury-a-rare-complication
#19
Shabeeba Sherin P P, Indulekha Shibu, Osama Neyaz, Anshini Gupta
Horner syndrome (HS) is a rare complication of anterior cervical decompression and fusion procedures (ACDF). A 42-year-old female presented with sudden-onset weakness in both upper and lower limbs secondary to trauma and was diagnosed with a spinal cord injury with tetraplegia. Her pre-operative findings were that her motor level of injury was C4 on the right and C5 on the left, and her sensory level of injury was C4 and C5, respectively, on the right and left sides. Her neurological injury level (NLI) was C4, and her ASIA Impairment Scale score was A...
June 2023: Curēus
https://read.qxmd.com/read/37339698/a-critical-appraisal-of-clinical-practice-guidelines-on-surgical-treatments-for-spinal-cord-injury
#20
REVIEW
Ruiyuan Zheng, Yuxuan Fan, Bin Guan, Runhan Fu, Liang Yao, Wei Wang, Guoyu Li, Yue Zhou, Lingxiao Chen, Shiqing Feng, Hengxing Zhou
BACKGROUND CONTEXT: Spinal cord injury (SCI) is a global health problem with a heavy economic burden. Surgery is considered as the cornerstone of SCI treatment. Although various organizations have formulated different guidelines on surgical treatment for SCI, the methodological quality of these guidelines has still not been critically appraised. PURPOSE: We aim to systematically review and appraise the current guidelines on surgical treatments of SCI and summarize the related recommendations with the quality evaluation of supporting evidence...
December 2023: Spine Journal: Official Journal of the North American Spine Society
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