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https://www.readbyqxmd.com/read/29792380/alirocumab-as-add-on-therapy-to-statins-current-evidence-and-clinical-potential
#1
Johann Auer, Robert Berent
Atherosclerotic cardiovascular diseases (ASCVDs) are associated with a substantial mortality, physical morbidity, and mental disability. Elevated plasma low-density lipoprotein cholesterol (LDL-C) levels play a major role in the pathophysiology of ASCVDs. Statins have been shown to reduce ASCVD risk and associated events and are recommended as first-line therapy for treatment of hypercholesterolemia by current international guidelines. The key issue is to attain guideline-recommended LDL-C levels (below 70 mg/dl) for patients at very high cardiovascular risk...
May 1, 2018: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/29788706/the-association-between-10-year-atherosclerotic-cardiovascular-diseases-risk-score-calculated-using-2013-american-college-of-cardiology-american-heart-association-guidelines-and-serum-25-hydroxyvitamin-d-level-among-aged-40-79-years-in-korea-the-sixth-korea
#2
Mun Hee Kim, Young Sang Kim, Hye Jin Oh, Yu Ri Kwon, Hye Won Kim
BACKGROUND: We examined the relationship between 10-year predicted atherosclerosis cardiovascular disease (ASCVD) risk score and 25-hydroxyvitamin D in Koreans aged 40-79 years. METHODS: A population-based, cross-sectional design was used from data based on the Korea National Health and Nutrition Examination Survey 2014. RESULTS: A total of 1,134 healthy Koreans aged 40-79 years were included. A positive relationship between serum 25-hydroxyvitamin D level and ASCVD score was shown in women (β=0...
May 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29777608/osteocalcin-value-to-identify-subclinical-atherosclerosis-over-atherosclerotic-cardiovascular-disease-ascvd-risk-score-in-middle-aged-and-elderly-chinese-asymptomatic-men
#3
Yiting Xu, Xiaojing Ma, Qin Xiong, Xueli Zhang, Yun Shen, Yuqian Bao
BACKGROUND: Our study examined whether osteocalcin contributed to identifying carotid intima-media thickness (C-IMT) over the atherosclerotic cardiovascular disease (ASCVD) risk score. METHODS: We recruited 618 middle-aged and elderly men from communities in Shanghai. Serum osteocalcin levels were determined using an electrochemiluminescence immunoassay. C-IMT was measured by ultrasonography. RESULTS: The study included 245 men with low ASCVD risk and 373 men with moderate-to-high ASCVD risk...
May 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29776564/the-prognostic-value-of-high-sensitivity-c-reactive-protein-in-a-multi-ethnic-population-after-10-years-of-follow-up-the-multi-ethnic-study-of-atherosclerosis-mesa
#4
Miguel Cainzos-Achirica, Michael D Miedema, John W McEvoy, Mary Cushman, Zeina Dardari, Philip Greenland, Khurram Nasir, Matthew J Budoff, Mouaz H Al-Mallah, Joseph Yeboah, Roger S Blumenthal, Josep Comin-Colet, Michael J Blaha
BACKGROUND: The prognostic value of hsCRP in contemporary multi-ethnic populations is unclear, particularly in statin users. The aim of this study was to characterize the prognostic utility of hsCRP for atherosclerotic CVD (ASCVD) risk prediction in a multi-ethnic population including non-users and users of statins followed for >13 years. Associations with heart failure (HF), atrial fibrillation (AF), venous thromboembolism (VTE), cancer, and all-cause death were also examined. METHODS AND RESULTS: We evaluated 6757 participants from the Multi-Ethnic Study of Atherosclerosis (MESA; 1002 using statins at baseline), median follow-up 13...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29756524/chest-pain-atherosclerotic-cardiovascular-disease-risk-and-cardiology-referral-in-primary-care
#5
Vishaal Buch, Hayley Ralph, Joanne Salas, Paul J Hauptman, Dawn Davis, Jeffrey F Scherrer
BACKGROUND: The atherosclerotic cardiovascular disease (ASCVD) 10-year risk estimate is recommended by cardiologists for determining risk of a cardiac event. However, the majority of patients presenting to primary care with chest pain have noncardiac etiologies. Therefore, we determined if high versus low ASCVD risk was associated with primary care physicians' referral to cardiology in patients with and without chest pain. METHODS: Deidentified electronic health record (EHR) data was obtained from 5795 patients treated in academic primary care clinics from 2008 to 2015...
January 2018: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/29756523/the-effect-of-health-education-by-pharmacists-on-10-year-atherosclerotic-cardiovascular-disease-risk-a-cluster-randomized-control-study-in-a-low-socioeconomic-status-javanese-population
#6
Rita Suhadi, Dita Maria Virginia, Christianus Heru Setiawan
BACKGROUND: Evidence from previous studies demonstrates that lifestyle modification reduces the incidence and complications of atherosclerotic cardiovascular disease. The study aimed to investigate the effect of a lifestyle intervention provided by pharmacists on the 10-year atherosclerotic cardiovascular disease (ASCVD) risk and quality of life (QoL) in a low socioeconomic status Javanese population. METHODS: This research was a cluster-randomized controlled study of 1-year duration, conducted in a lower social economic community in the Sleman District of Yogyakarta, Indonesia...
January 2018: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/29735297/utilization-patterns-of-lipid-lowering-therapies-in-patients-with-atherosclerotic-cardiovascular-disease-or-diabetes-a-population-based-study-in-south-korea
#7
Siin Kim, Hyungtae Kim, Eunju Kim, Sola Han, Pratik P Rane, Kathleen M Fox, Zhongyun Zhao, Yi Qian, Hae Sun Suh
PURPOSE: We aimed to study the utilization patterns of lipid-lowering treatment (LLT), including treatment modification, adherence, and possible statin intolerance, in patients with atherosclerotic cardiovascular disease (ASCVD) or diabetes using national claims data in South Korea. METHODS: A retrospective cohort study was conducted using data from the Korean Health Insurance Review & Assessment Service claims database. Patients aged ≥18 years with >1 outpatient pharmacy claim for a statin and/or ezetimibe dated January 1, 2012, to December 31, 2014, were identified and categorized into the following cohorts: patients with ASCVD, and patients with diabetes mellitus without ASCVD...
May 4, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29728015/race-ethnic-and-sex-differences-in-the-association-of-atherosclerotic-cardiovascular-disease-risk-and-healthy-lifestyle-behaviors
#8
Alanna A Morris, Yi-An Ko, Sarah H Hutcheson, Arshed Quyyumi
BACKGROUND: Lifestyle behaviors influence atherosclerotic cardiovascular disease (ASCVD) risk. We examined race and sex differences in the association of ASCVD risk with obesity and lifestyle behaviors. METHODS AND RESULTS: We used multivariable logistic regression to examine the association of race/ethnicity and sex with obesity and lifestyle behaviors among 12 351 adults in the National Health and Nutrition Examination Surveys cycles 2005 to 2014. Ten-year ASCVD risk was estimated using the 2013 American College of Cardiology/American Heart Association pooled cohort equations...
May 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29721777/ideal-cardiovascular-health-and-incidence-of-atherosclerotic-cardiovascular-disease-among-chinese-adults-the-china-par-project
#9
Chao Han, Fangchao Liu, Xueli Yang, Jichun Chen, Jianxin Li, Jie Cao, Ying Li, Chong Shen, Ling Yu, Zhendong Liu, Xianping Wu, Liancheng Zhao, Dongshen Hu, Xiangfeng Lu, Xigui Wu, Dongfeng Gu
Existing evidence on the relationship between cardiovascular health (CVH) metrics and cardiovascular disease (CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD (ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project (Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease (CHD), stroke and ASCVD death...
March 19, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29712560/cardiovascular-disease-risk-factor-responses-to-a-type-2-diabetes-care-model-including-nutritional-ketosis-induced-by-sustained-carbohydrate-restriction-at-1-year-an-open-label-non-randomized-controlled-study
#10
Nasir H Bhanpuri, Sarah J Hallberg, Paul T Williams, Amy L McKenzie, Kevin D Ballard, Wayne W Campbell, James P McCarter, Stephen D Phinney, Jeff S Volek
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in patients with T2D can be significantly improved through a continuous care intervention (CCI) including nutritional ketosis. The purpose of this study was to examine CVD risk factors in this cohort. METHODS: We investigated CVD risk factors in patients with T2D who participated in a 1 year open label, non-randomized, controlled study...
May 1, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29706275/medical-apps-used-during-advanced-pharmacy-practice-experiences
#11
Krista L Donohoe, Abigale T Matulewicz, Fawaz M Alotaibi, Kelechi C Ogbonna
BACKGROUND AND PURPOSE: The purpose of this study was to determine what type of medical applications (apps) are being used by fourth-year students during advanced pharmacy practice experiences (APPEs). EDUCATIONAL ACTIVITY AND SETTING: Recent doctor of pharmacy school graduates were surveyed pertaining to their use of medical apps on APPEs, frequency of use for select apps, willingness to buy apps and at what cost, and their perceived importance on using medical apps in their pharmacy practice...
February 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29705799/modeling-statin-induced-reductions-of-cardiovascular-events-in-primary-prevention-a-voyager-meta-analysis
#12
Björn W Karlson, Stephen J Nicholls, Pia Lundman, Philip J Barter, Michael K Palmer
OBJECTIVE: We used individual patient data from the VOYAGER database to estimate cardiovascular (CV) risk reduction with commonly used high-intensity statins. METHODS: In patients with known atherosclerotic CV disease (ASCVD) treated with high-intensity statin therapy (n = 6,735), the predicted risk reduction was estimated using the Cholesterol Treatment Trialists' Collaboration meta-analysis, which determined risk reduction per 38.7 mg/dL statin-mediated reduction in low-density lipoprotein cholesterol...
April 27, 2018: Cardiology
https://www.readbyqxmd.com/read/29703626/temporal-changes-in-statin-prescription-and-intensity-at-discharge-and-impact-on-outcomes-in-patients-with-newly-diagnosed-atherosclerotic-cardiovascular-disease-real-world-experience-within-a-large-integrated-health-care-system-the-impres-study
#13
Jeffrey L Anderson, Kirk U Knowlton, Heidi T May, Tami L Bair, Shannon O Armstrong, Donald L Lappé, Joseph B Muhlestein
BACKGROUND: Statins are indicated for secondary atherosclerotic cardiovascular disease (ASCVD) prevention; however, multiple surveys have found treatment gaps in clinical application. OBJECTIVE: To determine trends over 15 years in the prevalence and impact of a statin prescription and dose intensity at discharge after a first ASCVD event. METHODS: The Intermountain Enterprise Data Warehouse was searched to identify all adults with a first encounter for ASCVD between January 1, 1999 and December 31, 2013, including coronary artery disease, cerebrovascular disease, and peripheral arterial disease, who survived the index event and were followed for ≥3 years or until death...
March 30, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29688297/ten-year-association-of-coronary-artery-calcium-with-atherosclerotic-cardiovascular-disease-ascvd-events-the-multi-ethnic-study-of-atherosclerosis-mesa
#14
Matthew J Budoff, Rebekah Young, Gregory Burke, J Jeffrey Carr, Robert C Detrano, Aaron R Folsom, Richard Kronmal, Joao A C Lima, Kiang J Liu, Robyn L McClelland, Erin Michos, Wendy S Post, Steven Shea, Karol E Watson, Nathan D Wong
Aims: While coronary artery calcium (CAC) has been extensively validated for predicting clinical events, most outcome studies of CAC have evaluated coronary heart disease (CHD) rather than atherosclerotic cardiovascular disease (ASCVD) events (including stroke). Also, virtually all CAC studies are of short- or intermediate-term follow-up, so studies across multi-ethnic cohorts with long-term follow-up are warranted prior to widespread clinical use. We sought to evaluate the contribution of CAC using the population-based MESA cohort with over 10 years of follow-up for ASCVD events, and whether the association of CAC with events varied by sex, race/ethnicity, or age category...
April 23, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29686026/favorable-modifiable-cardiovascular-risk-profile-is-associated-with-lower-healthcare-costs-among-cancer-patients-the-2012-2013-medical-expenditure-panel-survey
#15
Jai Singh, Javier Valero-Elizondo, Joseph A Salami, Haider J Warraich, Oluseye Ogunmoroti, Erica S Spatz, Nihar Desai, Jamal S Rana, Salim S Virani, Ron Blankstein, Michael J Blaha, Khurram Nasir
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) and cancer are among the leading causes of economic burden, morbidity, and mortality in the United States. We aimed to quantify the overall impact of cardiovascular modifiable risk factor (CRF) profile on healthcare expenditures among those with and without ASCVD and/or cancer. METHODS AND RESULTS: The 2012-2013 Medical Expenditure Panel Survey, a nationally representative adult sample (≥40 years), was utilized for the study...
April 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29667200/treatment-in-a-preventive-cardiology-clinic-utilizing-advanced-practice-providers-apps-effectively-closes-atherosclerotic-cardiovascular-disease-ascvd-risk-management-gaps-amongst-a-primary-prevention-population-compared-with-a-propensity-matched-primary-care
#16
Emilio Fentanes, Anthony G Vande Hei, R Scott Holuby, Norma Suarez, Yousif Slim, Jennifer N Slim, Ahmad M Slim, Dustin Thomas
BACKGROUND: Advanced Practice Providers (APPs) can fill access to care gaps created by physician shortages and improve adherence/compliance with preventive atherosclerotic cardiovascular disease (ASCVD) interventions. METHODS: We retrospectively reviewed data on 595 patients enrolled in a preventive cardiology clinic (PCC) utilizing APPs compared with a propensity-matched cohort (PMC) of 595 patients enrolled in primary care clinics alone. PCC patients were risk stratified using Framingham risk scoring (FRS) and coronary artery calcium scoring (CACS) and treated based on published guideline-based algorithms...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29656789/voice-signal-characteristics-are-independently-associated-with-coronary-artery-disease
#17
Elad Maor, Jaskanwal D Sara, Diana M Orbelo, Lilach O Lerman, Yoram Levanon, Amir Lerman
OBJECTIVE: Voice signal analysis is an emerging noninvasive diagnostic tool. The current study tested the hypothesis that patient voice signal characteristics are associated with the presence of coronary artery disease (CAD). METHODS: The study population included 138 patients who were enrolled between January 1, 2015, and February 28, 2017: 37 control subjects and 101 subjects who underwent planned coronary angiogram. All subjects had their voice signal recorded to their smartphone 3 times: reading a text, describing a positive emotional experience, and describing a negative emotional experience...
April 12, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29650716/cardiovascular-genetic-risk-testing-for-targeting-statin-therapy-in-the-primary-prevention-of-atherosclerotic-cardiovascular-disease-a-cost-effectiveness-analysis
#18
Jamie Jarmul, Mark J Pletcher, Kristen Hassmiller Lich, Stephanie B Wheeler, Morris Weinberger, Christy L Avery, Daniel E Jonas, Stephanie Earnshaw, Michael Pignone
BACKGROUND: It is unclear whether testing for novel risk factors, such as a cardiovascular genetic risk score (cGRS), improves clinical decision making or health outcomes when used for targeting statin initiation in the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Our objective was to estimate the cost-effectiveness of cGRS testing to inform clinical decision making about statin initiation in individuals with low-to-intermediate (2.5%-7.5%) 10-year predicted risk of ASCVD...
April 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29643058/a-conceptual-framework-for-addressing-residual-atherosclerotic-cardiovascular-disease-risk-in-the-era-of-precision-medicine
#19
Kershaw V Patel, Ambarish Pandey, James A de Lemos
Until recently, therapies to mitigate atherosclerotic cardiovascular disease (ASCVD) risk have been limited to lifestyle interventions, blood pressure lowering medications, high intensity statin therapy, antiplatelet agents, and in select patients, coronary artery revascularization. Despite administration of these evidence-based therapies, substantial residual risk for cardiovascular events persists, particularly among individuals with known ASCVD. Moreover, the current guideline-based approach does not adequately account for patient-specific, causal pathways that lead to ASCVD progression and complications...
April 11, 2018: Circulation
https://www.readbyqxmd.com/read/29622441/prevalence-of-dyslipidemia-and-achievement-of-low-density-lipoprotein-cholesterol-targets-in-chinese-adults-a-nationally-representative-survey-of-163-641-adults
#20
Mei Zhang, Qian Deng, Linhong Wang, Zhengjing Huang, Maigeng Zhou, Yichong Li, Zhenping Zhao, Yawei Zhang, Limin Wang
BACKGROUND: Elevated serum total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels are established risk factors for cardiovascular diseases, a leading cause of death in China. We sought to assess the latest levels of serum lipids, prevalence of dyslipidemia and achievement of LDL-C lowering targets among Chinese adults. METHODS: Data was obtained from a national representative survey recruited 163,641 adults aged >18years in mainland China between 2013 and 2014...
June 1, 2018: International Journal of Cardiology
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