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https://www.readbyqxmd.com/read/29322696/the-j-curve-between-diastolic-blood-pressure-and-risk-of-all-cause-and-cardiovascular-death
#1
Heejin Kimm, Yejin Mok, Sun Ju Lee, Sunmi Lee, Joung Hwan Back, Sun Ha Jee
BACKGROUND AND OBJECTIVES: The J-curve phenomenon between diastolic blood pressure (DBP) and mortality has been reported repeatedly in treated patients. However, the baseline risk of low DBP has not been fully explored. This study was to examine the relationship between DBP and risk of mortality from all-cause, atherosclerotic vascular diseases (ASCVD), and ischemic heart disease (IHD) using a prospective cohort of general population. METHODS: We analyzed 1,234,435 participants of the Korean Cancer Prevention Study cohort (789,255 men, 30-95 years of age) who had a medical evaluation from 1992 to 1995 using Cox proportional hazards models...
January 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29322167/use-of-high-risk-coronary-atherosclerotic-plaque-detection-for-risk-stratification-of-patients-with-stable-chest-pain-a-secondary-analysis-of-the-promise-randomized-clinical-trial
#2
Maros Ferencik, Thomas Mayrhofer, Daniel O Bittner, Hamed Emami, Stefan B Puchner, Michael T Lu, Nandini M Meyersohn, Alexander V Ivanov, Elizabeth C Adami, Manesh R Patel, Daniel B Mark, James E Udelson, Kerry L Lee, Pamela S Douglas, Udo Hoffmann
Importance: Coronary computed tomographic angiography (coronary CTA) can characterize coronary artery disease, including high-risk plaque. A noninvasive method of identifying high-risk plaque before major adverse cardiovascular events (MACE) could provide practice-changing optimizations in coronary artery disease care. Objective: To determine whether high-risk plaque detected by coronary CTA was associated with incident MACE independently of significant stenosis (SS) and cardiovascular risk factors...
January 10, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29305561/trends-in-cardiovascular-risk-factor-and-disease-prevalence-in-patients-undergoing-non-cardiac-surgery
#3
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Joshua A Beckman, Sripal Bangalore, Jeffrey S Berger
OBJECTIVES: Cardiovascular risk factors are prevalent in the population undergoing non-cardiac surgery. Changes in perioperative cardiovascular risk factor profiles over time are unknown. The objective of this study was to evaluate national trends in cardiovascular risk factors and atherosclerotic cardiovascular disease (ASCVD) among patients undergoing non-cardiac surgery. METHODS: Adults aged ≥45 years old who underwent non-cardiac surgery were identified using the US National Inpatient Sample from 2004 to 2013...
January 5, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29277495/clinical-pharmacist-understanding-of-the-2013-american-college-of-cardiology-american-heart-association-cholesterol-guideline
#4
John D Bucheit, Haleigh Helsing, Pramit Nadpara, Salim S Virani, Dave L Dixon
BACKGROUND: Clinical pharmacists are frequently involved in the management of dyslipidemia, yet clinical pharmacists' knowledge, awareness, and the level of agreement with the 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol guideline are unknown. OBJECTIVE: The objective of the study was to examine clinical pharmacists' knowledge, awareness, and the level of agreement with the 2013 ACC/AHA cholesterol guideline. METHODS: We administered a validated questionnaire via an online survey that was electronically mailed to clinical pharmacists...
December 6, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29277441/iga-antibodies-to-phosphocholine-associate-with-long-term-cardiovascular-disease-risk
#5
Jari Kankaanpää, Maritta Sämpi, Risto Bloigu, Chunguang Wang, Ramin Akhi, Y Antero Kesäniemi, Anne M Remes, Olavi Ukkola, Sohvi Hörkkö
BACKGROUND AND AIMS: Antibodies to phosphocholine and oxidized LDL (oxLDL) are proposed to modify progression of atherosclerosis. We investigated the prognostic value of antibodies to phosphocholine (PCho), Streptococcus pneumoniae cell wall polysaccharide (CWPS) and oxLDL in defining long-term CVD survival. METHODS: CVD incidence was followed for 18 years and analyzed with baseline plasma IgM, IgG and IgA antibody levels to PCho, CWPS and oxLDL in 1044 subjects of Oulu Project Elucidating Risk of Atherosclerosis study (OPERA)...
December 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29276295/cholesterol-ester-transfer-protein-inhibitor-review
#6
Jerry Hu, Scot Walker
Treatment of blood cholesterol is part of a strategy to lower atherosclerotic cardiovascular (ASCVD) risk. While use of HMG-CoA reductase inhibitors to modify cholesterol levels is the primary means of lowering the risk of an ASCVD event, residual risk remains. A new strategy being investigated is the use of cholesterol ester transfer protein (CETP) inhibitors to raise the levels of high-density lipoprotein cholesterol (HDL-C) and lower low-density lipoprotein cholesterol (LDL-C). While initial large-scale studies demonstrated no reduction of cardiovascular events, one CETP inhibitor, anacetrapib, has demonstrated a reduction in cardiovascular events in the REVEAL trial...
October 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29276211/treatment-patterns-statin-intolerance-and-subsequent-cardiovascular-events-among-japanese-patients-with-high-cardiovascular-risk-initiating-statin-therapy
#7
Saurabh P Nagar, Pratik P Rane, Kathleen M Fox, Juliana Meyers, Keith Davis, Anne Beaubrun, Hyoe Inomata, Yi Qian, Kouji Kajinami
BACKGROUND: This study examined treatment patterns, possible statin intolerance, and incidence of cardiovascular events (CVEs) in 2 cohorts of patients with high cardiovascular risk (i.e., patients with atherosclerotic cardiovascular disease [ASCVD] and patients with diabetes mellitus).Methods and Results:A retrospective cohort study examined adults initiating either a statin or ezetimibe from 1 January 2006 to 31 May 2014 in the Japan Medical Data Center database. The first observed statin or ezetimibe prescription defined the index date...
December 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29274849/predictors-of-carotid-plaque-progression-over-a-4-year-follow-up-in-the-reykjavik-refine-study
#8
Ran Sturlaugsdottir, Thor Aspelund, Gudlaug Bjornsdottir, Sigurdur Sigurdsson, Bolli Thorsson, Gudny Eiriksdottir, Vilmundur Gudnason
BACKGROUND AND AIMS: Carotid plaque is an arterial marker suggested as a surrogate end point for cardiovascular disease. The aim of this study was to examine the association of risk factors at visit 1 with plaque formation and progression of total plaque area (TPA) during follow-up. METHODS: We examined 1894 participants (50-69 years of age) in the population-based REFINE (Risk Evaluation For INfarct Estimates)-Reykjavik study. RESULTS: Among those with no plaque at baseline, plaque formation was associated with low density lipoprotein, sex, waist, former smoker and physical activity...
December 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29274507/mediterranean-diet-improves-endothelial-function-in-patients-with-diabetes-and-prediabetes-a-report-from-the-cordioprev-study
#9
Jose D Torres-Peña, Antonio Garcia-Rios, Nieves Delgado-Casado, Purificacion Gomez-Luna, Juan F Alcala-Diaz, Elena M Yubero-Serrano, Francisco Gomez-Delgado, Ana Leon-Acuña, Javier Lopez-Moreno, Antonio Camargo, Francisco J Tinahones, Javier Delgado-Lista, Jose M Ordovas, Pablo Perez-Martinez, Jose Lopez-Miranda
BACKGROUND AND AIMS: Endothelial dysfunction (ED) plays a key role in the development of atherosclerotic cardiovascular disease (ASCVD). Likewise, type 2 diabetes (T2D) is a major CVD risk factor. Therefore, our objective was to explore whether long-term consumption of a Mediterranean diet (MedDiet) rich in olive oil or a low-fat diet (LF diet) was associated with an improvement in ED and whether the potential benefits were similar in patients with or without T2D in the CORDIOPREV clinical trial (NCT00924937)...
December 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29245109/autosomal-recessive-hypercholesterolemia-in-spain
#10
Rosa María Sánchez-Hernández, Pablo Prieto-Matos, Fernando Civeira, Eduardo Esteve Lafuente, Manuel Frías Vargas, José T Real, Fernando Goñi Goicoechea, Francisco J Fuentes, Miguel Pocovi, Mauro Boronat, Ana María Wägner, Luis Masana
BACKGROUND AND AIMS: Autosomal recessive hypercholesterolemia (ARH) is a very rare disease, caused by mutations in LDL protein receptor adaptor 1 (LDLRAP1). It is characterized by high levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of premature cardiovascular disease. We aimed to characterize ARH in Spain. METHODS: Data were collected from the Dyslipidemia Registry of the Spanish Atherosclerosis Society. A literature search was performed up to June 2017, and all diagnostic genetic studies for familial hypercholesterolemia of Spain were reviewed...
December 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29223956/residual-risk-of-atherosclerotic-cardiovascular-events-in-relation-to-reductions-in-very-low-density-lipoproteins
#11
Patrick R Lawler, Akintunde O Akinkuolie, Paulo Harada, Robert J Glynn, Daniel I Chasman, Paul M Ridker, Samia Mora
BACKGROUND: It is uncertain whether pharmacological reductions in very-low-density lipoproteins (VLDLs), and their component triglyceride and cholesterol could reduce residual risk of atherosclerotic cardiovascular disease (ASCVD) events among individuals in whom low-density lipoprotein cholesterol (LDL-C) has been adequately lowered. We examined whether individuals with greater on-statin reductions in VLDL-related measures-beyond reductions in LDL-C-were at further reduced risk of ASCVD...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29213285/low-levels-of-sex-hormone-binding-globulin-constitute-an-independent-risk-factor-for-arterial-stiffness-in-korean-women
#12
Kunhee Han, Hyejin Chun, Moon-Jong Kim, Doo-Yeoun Cho, Soo-Hyun Lee, Bo Youn Won, Kwang-Min Kim, Nam-Seok Joo, Young-Sang Kim
The association between sex hormone-binding globulin (SHBG) and arterial stiffness in women is not conclusive. In addition, obesity might also be involved in the relationship between SHBG and atherosclerosis. The aim of this study was to determine the relationship between SHBG and arterial stiffness in association with central obesity in women. This cross-sectional study included 381 women who participated in the health checkup programs in one hospital. The brachial-ankle pulse wave velocity (baPWV) was measured as a marker for arterial stiffness...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29212549/hypertriglyceridemia-and-atherosclerosis
#13
REVIEW
Jia Peng, Fei Luo, Guiyun Ruan, Ran Peng, Xiangping Li
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and it has been confirmed that increased low density lipoprotein cholesterol (LDL-C) is an independent risk factor for atherosclerosis. Recently, the increasing evidence has showed that hypertriglyceridemia is associated with incremental ASCVD risk. But the proatherogenic mechanism of triglyceride (TG) remains unclear. Therefore, this article focuses on the clinical studies and proatherogenic mechanism related to hypertriglyceridemia, in order to provide reference for the prevention and treatment of ASCVD...
December 6, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29197254/utilization-of-lipid-modifying-therapy-and-low-density-lipoprotein-cholesterol-goal-attainment-in-patients-at-high-and-very-high-cardiovascular-risk-real-world-evidence-from-germany
#14
Winfried März, Franz-Werner Dippel, Karlheinz Theobald, Katherine Gorcyca, Şerban R Iorga, David Ansell
BACKGROUND AND AIMS: Elevated low-density lipoprotein cholesterol (LDL-C) is a causal risk factor for cardiovascular (CV) events. European guidelines recommend reducing LDL-C as the primary lipid target to reduce CV risk, using lifestyle modifications and lipid-lowering therapy (LLT). Many European patients do not achieve guideline-recommended LDL-C levels. The present database analysis aimed to assess LLT treatment patterns and LDL-C threshold attainment in Germany in a large, real-world cohort of patients...
November 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29194590/effectiveness-of-statins-as-primary-prevention-in-people-with-different-cardiovascular-risk-a-population-based-cohort-study
#15
Maria Garcia-Gil, Marc Comas-Cufí, Jordi Blanch, Ruth Martí, Anna Ponjoan, Lia Alves-Cabratosa, Irene Petersen, Jaume Marrugat, Roberto Elosua, María Grau, Rafel Ramos
To analyze statin effectiveness in a general population with differing levels of coronary heart disease (CHD) risk. Patients (35-74 years) without previous cardiovascular disease were included and stratified according to 10-year CHD risk (<5%, ≥5-7.4%, ≥7.5-9.9%, and ≥10-19.9%). New users were categorized according to their medical possession ratio (MPR). Main outcome was ASCVD (myocardial infarction and ischemic stroke). In adherent patients (MPR ≥70%), statin treatment decreased ASCVD risk across the range of coronary risk (from 16% to 30%)...
December 1, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29193936/-evaluation-of-cardiovascular-risk-factors-in-obesity-before-and-after-bariatric-surgery
#16
Karla Leticia Sánchez-Ruiz, Aldo Ferreira-Hermosillo, Mario Antonio Molina-Ayala, Claudia Ramírez-Rentería, Victoria Mendoza-Zubieta
BACKGROUND: Mexico has one of the highest prevalences of severe obesity worldwide. Mortality in those patients may be as high as 90% mainly due to cardiovascular disease. Despite Framingham score has been validated in the Mexican population, it only predicts cardiovascular risk at 10 years. Meanwhile ASCVD10 score could evaluate risk at 10 years and through lifetime. None of these scores have been used for cardiovascular risk assessment in Mexican patients with severe obesity. METHODS: We conducted a quasi-experimental (before/ after) study with 109 patients with severe obesity, assessed prevalence of comorbidities, performed anthropometric and biochemical evaluations before and a year after bariatric surgery...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29185378/matching-microsimulation-risk-factor-correlations-to-cross-sectional-data-the-shortest-distance-method
#17
Sze-Chuan Suen, Jeremy D Goldhaber-Fiebert, Sanjay Basu
BACKGROUND: Microsimulation models often compute the distribution of a simulated cohort's risk factors and medical outcomes over time using repeated waves of cross-sectional data. We sought to develop a strategy to simulate how risk factor values remain correlated over time within individuals, and compare it to available alternative methods. METHODS: We developed a method using shortest-distance matching for modeling changes in risk factors in individuals over time, which preserves both the cohort distribution of each risk factor as well as the cross-sectional correlation between risk factors observed in repeated cross-sectional data...
November 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29182745/unmet-need-for-primary-prevention-in-individuals-with-hypertriglyceridaemia-not-eligible-for-statin-therapy-according-to-european-society-of-cardiology-european-atherosclerosis-society-guidelines-a-contemporary-population-based-study
#18
Christian M Madsen, Anette Varbo, Børge G Nordestgaard
Aims: To identify individuals at high risk of atherosclerotic cardiovascular disease (ASCVD), who are not definite statin eligible according to the 2016 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines, based on high concentrations of plasma triglycerides. Methods and results: From the Copenhagen General Population Study (2003-2015) 58 547 individuals aged 40-65 and free of ASCVD, diabetes, and statin use at baseline were included...
November 22, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29173602/association-between-circulating-oxidized-ldl-and-atherosclerotic-cardiovascular-disease-a-meta-analysis-of-observational-studies
#19
REVIEW
Shen Gao, Dong Zhao, Miao Wang, Fan Zhao, Xueyu Han, Yue Qi, Jing Liu
BACKGROUND: Although basic research has suggested that oxidized low-density lipoprotein (ox-LDL) is involved in the pathogenesis of atherosclerosis, population observational studies have yielded conflicting results about the association between circulating ox-LDL and atherosclerotic cardiovascular disease (ASCVD). Therefore, we performed a systematic review and meta-analysis of currently available observational studies to verify the association between circulating ox-LDL and ASCVD. METHODS: We systematically searched PubMed and the Cochrane Library from their inception to March 27, 2017, for nested case-control studies, case-cohort studies, and prospective cohort studies on the relationship between ox-LDL and ASCVD...
December 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29172973/ezetimibe-use-and-ldl-c-goal-achievement-a-retrospective-database-analysis-of-patients-with-clinical-atherosclerotic-cardiovascular-disease-or-probable-heterozygous-familial-hypercholesterolemia
#20
Joseph Menzin, Jyoti Aggarwal, Brian Boatman, Jeffrey Yu, Kevin Stern, David J Harrison, Jeetvan G Patel
BACKGROUND: Ezetimibe is recommended by clinical practice guidelines as a second-line therapy for lowering low-density lipoprotein cholesterol (LDL-C) levels, but little is known about its use and effectiveness in real-world populations. OBJECTIVE: To understand the real-world impact of adding or switching to ezetimibe on LDL-C goal achievement in patients with clinical atherosclerotic cardiovascular disease (ASCVD) and/or heterozygous familial hypercholesterolemia (HeFH)...
December 2017: Journal of Managed Care & Specialty Pharmacy
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