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https://www.readbyqxmd.com/read/29333818/community-acquired-methicillin-resistant-staphylococcus-aureus-infections-hospitalization-and-case-fatality-risk-in-10-pediatric-facilities-in-argentina
#1
Ángela Gentile, Julia Bakir, Gabriela Ensinck, Aldo Cancellara, Enrique V Casanueva, Verónica Firpo, Martín Caruso, María F Lución, Alejandro Santillán Iturres, Fabiana Molina, Héctor J Abate, Andrea Gajo Gane, Santiago López Papucci
INTRODUCTION: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are prevalent both in Argentina and worldwide, and they may have a severe clinical course. OBJECTIVES: To estimate the hospitalization rate and case fatality risk factors of CA-MRSA infection. METHODS: Cross-sectional, analytical study. All patients < 15 years old with community-acquired Staphylococcus aureus (CA-SA) infections admitted to 10 pediatric facilities between January 2012 and December 2014 were included...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29325529/a-multiple-imputation-method-based-on-weighted-quantile-regression-models-for-longitudinal-censored-biomarker-data-with-missing-values-at-early-visits
#2
MinJae Lee, Mohammad H Rahbar, Matthew Brown, Lianne Gensler, Michael Weisman, Laura Diekman, John D Reveille
BACKGROUND: In patient-based studies, biomarker data are often subject to left censoring due to the detection limits, or to incomplete sample or data collection. In the context of longitudinal regression analysis, inappropriate handling of these issues could lead to biased parameter estimates. We developed a specific multiple imputation (MI) strategy based on weighted censored quantile regression (CQR) that not only accounts for censoring, but also missing data at early visits when longitudinal biomarker data are modeled as a covariate...
January 11, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29317375/does-doxorubicin-survive-thermal-ablation-results-of-an-ex-vivo-bench-top-study
#3
Joseph D Morrison, Collin K Schlager, Amanda E Lee, Richard B van Breemen, Ron C Gaba
PURPOSE: We aimed to test the hypothesis that doxorubicin (DOX) survives thermal ablative heating in an ex vivo model of combined transarterial chemoembolization (TACE) and thermal ablation. METHODS: Fresh porcine psoas major muscle (3 samples, 15×10×3 cm) was submerged in aqueous DOX solution (60 µg/mL, 0.1 M) for 24 hours to passively saturate tissue. DOX-infused tissue was then dried and treated with microwave ablation (MWA) using a 2.45 GHz antenna at 65 W for 2, 5, and 10 minutes...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29317046/retro-peritoneal-cooling-for-kidney-preservation-from-multi-organ-cadaver-donors
#4
Anastasio Salazar-Bañuelos, Mauricio Monroy-Cuadros, Hoover Henriquez-Cooper
BACKGROUND: Minimizing ischemia is paramount in the procurement of kidneys for transplantation. A fast cooling and expeditious removal is ideal to minimize damage from warm ischemia, however, since the removal of kidneys is delayed in cadaver donation until all other organs are harvested, the risk of kidney damage increases due to contact with the warmer soft body tissues. Surgical techniques that expedite organ retrieval were developed to avoid organ damage. METHODS: We test a modification of Thomas Starzl's improved technique for multi-organ harvesting by interposing an ice bag between the posterior aspect of the kidney and the psoas muscle in a randomized trial with 21 multi-organ cadaver donors...
January 4, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29315315/quantification-of-intramuscular-fat-in-patients-with-late-onset-pompe-disease-by-conventional-magnetic-resonance-imaging-for-the-long-term-follow-up-of-enzyme-replacement-therapy
#5
André Lollert, Clemens Stihl, Andreas M Hötker, Eugen Mengel, Jochem König, Katharina Laudemann, Seyfullah Gökce, Christoph Düber, Gundula Staatz
OBJECTIVE: The objective of this study was to evaluate a quantitative method based on conventional T1-weighted magnetic resonance (MR) imaging to assess fatty muscular degeneration in patients with late-onset Pompe disease and to compare it with semi-quantitative visual evaluation (the Mercuri score). In addition, a long-term retrospective data analysis was performed to evaluate treatment response to enzyme replacement therapy with alglucosidase alfa. METHODS: MR images of the lumbar spine were acquired in 41 patients diagnosed with late-onset Pompe disease from 2006 through 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29312971/impact-of-sarcopenic-overweight-on-the-outcomes-after-living-donor-liver-transplantation
#6
Ahmed Hammad, Toshimi Kaido, Yuhei Hamaguchi, Shinya Okumura, Atsushi Kobayashi, Hisaya Shirai, Naoko Kamo, Shintaro Yagi, Shinji Uemoto
Background: The effect of body composition disturbances has been recently in focus. Sarcopenic obesity, a co-occurrence of low muscle mass and high body fat was reportedly predictive of high mortality in patients with cirrhosis. However, the impact of the interacting sarcopenia and overweight on the outcomes after liver transplantation is still unclear. Methods: We evaluated 200 patients undergoing adult-to-adult living donor liver transplantation at our institution between January 2008 and November 2013 classified according to BMI and psoas muscle index (PMI) on admission to transplant into 4 subgroups; sarcopenic overweight (SO), sarcopenic non-overweight (SN), non-sarcopenic overweight and non-sarcopenic non-overweight (NN)...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29310649/multi-parametric-muscle-and-fat-correlation-of-computed-tomography-parameters-to-outcomes-in-a-total-hip-arthroplasty-population
#7
Michael A Heffler, Ryan Barlow, Yin Xi, Daichi Hayashi, Hayden Box, Michael Huo, Avneesh Chhabra
BACKGROUND: Cross-sectional imaging is not currently used in planning Total Hip Arthroplasty (THA). The aim of our study is to determine correlations between CT parameters and outcomes following THA. METHODS: A prospective registry of patients who underwent total joint arthroplasty was reviewed for patients who: (1) underwent THA, (2) had a CT between 1 year before and 6 months after surgery, and (3) completed perioperative WOMAC and Harris Hip Score (HHS) questionnaires...
January 8, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29310350/relationship-between-skeletal-muscle-mass-and-liver-fibrosis-markers-for-patients-with-hepatitis-c-virus-related-liver-disease
#8
Ryo Takata, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yuho Miyamoto, Noriko Ishii, Yukihisa Yuri, Kunihiro Hasegawa, Chikage Nakano, Takashi Nishimura, Kazunori Yoh, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
We aimed to elucidate the relationship between serum liver fibrosis markers (Mac-2 binding protein glycosylation isomer (M2BPGi), FIB-4 index, aspartate aminotransferase to platelet ratio index and hyaluronic acid), and skeletal muscle mass and to investigate factors linked to skeletal muscle mass loss (SMML) in patients with chronic hepatitis C (CHC, n = 277, median age = 64 years). We defined patients with psoas muscle index [PMI, sum of bilateral psoas muscle mass calculated by manual trace method at the lumber 3 level on the computed tomography images divided by height squared (cm/m)] less than 6...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29299352/a-semi-automated-assessment-of-sarcopenia-using-psoas-area-and-density-predicts-outcomes-after-pancreaticoduodenectomy-for-pancreatic-malignancy
#9
Jukes P Namm, Kiran H Thakrar, Chi-Hsiung Wang, Susan J Stocker, Malini D Sur, Jonathan Berlin, William Dale, Mark S Talamonti, Kevin K Roggin
Background: Sarcopenia has been associated with increased adverse outcomes after major abdominal surgery. Sarcopenia defined as decreased muscle volume or increased fatty infiltration may be a proxy for frailty. In conjunction with other preoperative clinical risk factors, radiographic measures of sarcopenia using both muscle size and density may enhance prediction of outcomes after pancreaticoduodenectomy (PD) for malignancy. Methods: Preoperative computed tomography (CT) scans of patients undergoing PD for malignancy were analyzed from a prospective pancreatic surgery database...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29291007/alteration-of-muscle-fiber-characteristics-and-the-ampk-sirt1-pgc-1%C3%AE-axis-in-skeletal-muscle-of-growing-pigs-fed-low-protein-diets-with-varying-branched-chain-amino-acid-ratios
#10
Yehui Duan, Fengna Li, Wenlong Wang, Qiuping Guo, Chaoyue Wen, Yulong Yin
There mainly exists four major myosin heavy chains (MyHC) (i.e., I, IIa, IIx, and IIb) in growing pigs. The current study aimed to explore the effects of low-protein diets supplemented with varying branched-chain amino acids (BCAAs) on muscle fiber characteristics and the AMPK-SIRT1-PGC-1α axis in skeletal muscles. Forty growing pigs (9.85 ± 0.35 kg) were allotted to 5 groups and fed with diets supplemented with varying leucine: isoleucine: valine ratios: 1:0.51:0.63 (20% crude protein, CP), 1:1:1 (17% CP), 1:0...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290128/short-term-outcomes-of-lateral-lumbar-interbody-fusion-without-decompression-for-the-treatment-of-symptomatic-degenerative-spondylolisthesis-at-l4-5
#11
Peter G Campbell, Pierce D Nunley, David Cavanaugh, Eubulus Kerr, Philip Andrew Utter, Kelly Frank, Marcus Stone
OBJECTIVE Recently, authors have called into question the utility and complication index of the lateral lumbar interbody fusion procedure at the L4-5 level. Furthermore, the need for direct decompression has also been debated. Here, the authors report the clinical and radiographic outcomes of transpsoas lumbar interbody fusion, relying only on indirect decompression to treat patients with neurogenic claudication secondary to Grade 1 and 2 spondylolisthesis at the L4-5 level. METHODS The authors conducted a retrospective evaluation of 18 consecutive patients with Grade 1 or 2 spondylolisthesis from a prospectively maintained database...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29288787/robotic-appendiceal-interposition-with-right-lower-pole-calycostomy-downward-nephropexy-and-psoas-hitch-for-the-management-of-an-iatrogenic-near-complete-ureteral-avulsion
#12
Martus Gn, Ziho Lee, David Strauss, Daniel Eun
Although iatrogenic ureteral injuries are rare, they have potentially devastating consequences for both patients and physicians, and their management remains challenging. We report a case of a 51-year-old morbidly obese (BMI=63) female who suffered an iatrogenic 15 centimeter right ureteral avulsion during hysteroscopic biopsy. Preoperative antegrade and retrograde pyelograms demonstrated no true renal pelvis and a 3 centimeter blind-ending distal ureteral stump. The patient underwent a right robotic downward nephropexy, psoas hitch, lower pole calycostomy and 11 cm appendiceal interposition...
December 27, 2017: Urology
https://www.readbyqxmd.com/read/29287785/evaluation-of-muscle-activity-just-after-straight-leg-raising-exercise-by-using-18fdg-pet
#13
Hiroyuki Shiozawa, Takashi Ohsawa, Yoshito Tsushima, Tetsuya Higuchi, Kenji Takagishi, Hirotaka Chikuda
BACKGROUND: Exercise therapy is one of the recognized treatment methods for knee osteoarthritis (KOA). One such exercise technique, straight leg raising (SLR), is widely known as a home exercise method for strengthening the quadriceps femoris muscle. However, whether this exercise truly strengthens the quadriceps is not known. The objective of the present study was to investigate which lower limb muscle is stimulated and shows increased activity with SLR. METHODS: A total of 14 lower limbs in seven healthy adult male volunteers (mean age: 31...
December 26, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29281150/to-distinguish-flexible-and-rigid-lumbar-curve-from-mri-texture-analysis-in-adolescent-idiopathic-scoliosis-a-feasibility-study
#14
Claudia Chevrefils, Delphine Périé, Stefan Parent, Farida Cheriet
BACKGROUND: Imaging in side bending, supine, traction, fulcrum, and push prone are examples of methods used to evaluate the curve reduction of scoliotic spine. However, being able to determine spine curve flexibility from MRI would eliminate the need of additional X-ray radiation related to radiograph acquisition in side-bending. PURPOSE/HYPOTHESIS: To find specific texture features of lumbar postural muscles on MRI that can distinguish flexible from rigid lumbar scoliotic curves...
December 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29280355/muscles-of-the-trunk-and-pelvis-are-responsive-to-testosterone-administration-data-from-testosterone-dose-response-study-in-young-healthy-men
#15
J Tapper, S Arver, K M Pencina, A Martling, L Blomqvist, C Buchli, Z Li, T Gagliano-Jucá, T G Travison, G Huang, T W Storer, S Bhasin, S Basaria
Testosterone dose-dependently increases appendicular muscle mass. However, the effects of testosterone administration on the core muscles of the trunk and the pelvis have not been evaluated. The present study evaluated the effects of testosterone administration on truncal and pelvic muscles in a dose-response trial. Participants were young healthy men aged 18-50 years participating in the 5α-Reductase (5aR) Trial. All participants received monthly injections of 7.5 mg leuprolide acetate to suppress endogenous testosterone production and weekly injections of 50, 125, 300, or 600 mg of testosterone enanthate and were randomized to receive either 2...
January 2018: Andrology
https://www.readbyqxmd.com/read/29279595/pseudomyogenic-epithelioid-sarcoma-like-hemangioendothelioma-a-rare-vascular-neoplasm-with-deceptive-morphology-and-distinctive-immunophenotype
#16
F F Cheo, K Sittampalam
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a rare, low grade vascular (endothelial) neoplasm typically presenting as multicentric, superficial to deep nodules in extremities with a slight tendency of affecting young adult males. We report a case of pseudomyogenic hemangioendothelioma in a 15-year-old boy presenting initially with a 1 cm right thigh painless cutaneous lump. The lump was excised with the clinical impression of a sebaceous cyst. On microscopy, a poorly circumscribed, mild to moderately atypical spindle cell lesion in fascicular and storiform patterns with strikingly myoid-like eosinophilic cytoplasm was identified...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29277239/do-psoas-muscle-area-and-volume-correlate-with-postoperative-complications-in-patients-undergoing-rectal-cancer-resection
#17
Aaron L Womer, Justin T Brady, Kevin Kalisz, Nilam D Patel, Raj M Paspulati, Harry L Reynolds, Timothy M Pawlik, Scott R Steele
BACKGROUND: Increasingly, patients with multiple co-morbidities undergo surgery for rectal cancer. We aimed to evaluate if decreased psoas muscle area and volume, as measures for sarcopenia, were associated with postoperative morbidity. METHODS: Retrospective review of patients undergoing rectal cancer resection at a tertiary medical center (2007-2015). Variables included demographics, co-morbidities, preoperative psoas muscle area and volume, and postoperative complications...
November 21, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29276105/grip-strength-measurement-for-frailty-assessment-in-patients-with-vascular-disease-and-associations-with-comorbidity-cardiac-risk-and-sarcopenia
#18
Thomas E Reeve, Rebecca Ur, Timothy E Craven, James H Kaan, Matthew P Goldman, Matthew S Edwards, Justin B Hurie, Gabriela Velazquez-Ramirez, Matthew A Corriere
OBJECTIVE: Frailty is associated with adverse events, length of stay, and nonhome discharge after vascular surgery. Frailty measures based on walking-based tests may be impractical or invalid for patients with walking impairment from symptoms or sequelae of vascular disease. We hypothesized that grip strength is associated with frailty, comorbidity, and cardiac risk among patients with vascular disease. METHODS: Dominant hand grip strength was measured during ambulatory clinic visits among patients with vascular disease (abdominal aortic aneurysm [AAA], carotid stenosis, and peripheral artery disease [PAD])...
December 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29249561/posterior-contained-rupture-of-an-abdominal-aortic-aneurysm-within-the-psoas-muscle-after-endovascular-repair
#19
Efstratios Georgakarakos, Symeon Dimitriadis
No abstract text is available yet for this article.
December 14, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29249454/biomechanical-consequences-of-running-with-deep-core-muscle-weakness
#20
Margaret E Raabe, Ajit M W Chaudhari
The deep core muscles are often neglected or improperly trained in athletes. Improper function of this musculature may lead to abnormal spinal loading, muscle strain, or injury to spinal structures, all of which have been associated with increased low back pain (LBP) risk. The purpose of this study was to identify potential strategies used to compensate for weakness of the deep core musculature during running and to identify accompanying changes in compressive and shear spinal loads. Kinematically-driven simulations of overground running were created for eight healthy young adults in OpenSim at increasing levels of deep core muscle weakness...
December 6, 2017: Journal of Biomechanics
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