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https://www.readbyqxmd.com/read/28088670/fibrin-hydrogels-induce-mixed-dorsal-ventral-spinal-neuron-identities-during-differentiation-of-human-induced-pluripotent-stem-cells
#1
John M Edgar, Meghan Robinson, Stephanie M Willerth
: We hypothesized that generating spinal motor neurons (sMNs) from human induced pluripotent stem cell (hiPSC)-derived neural aggregates (NAs) using a chemically-defined differentiation protocol would be more effective inside of 3D fibrin hydrogels compared to 2D poly-L-ornithine(PLO)/laminin-coated tissue culture plastic surfaces. We performed targeted RNA-Seq using next generation sequencing to determine the substrate-specific differences in gene expression that regulate cell phenotype...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28088667/cell-laden-hydrogels-for-osteochondral-and-cartilage-tissue-engineering
#2
REVIEW
Jingzhou Yang, Yu Shrike Zhang, Kan Yue, Ali Khademhosseini
: Despite tremendous advances in the field of regenerative medicine, it still remains challenging to repair the osteochondral interface and full-thickness articular cartilage defects. This inefficiency largely originates from the lack of appropriate tissue engineered artificial matrices that can replace the damaged regions and promote tissue regeneration. Hydrogels are emerging as a promising class of biomaterials for both soft and hard tissue regeneration. Many critical properties of hydrogels, such as mechanical stiffness, elasticity, water content, bioactivity, and degradation, can be rationally designed and conveniently tuned by proper selection of the material and chemistry...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28088565/rapid-microwave-assisted-growth-of-silver-nanoparticles-on-3d-graphene-networks-for-supercapacitor-application
#3
S Khamlich, T Khamliche, M S Dhlamini, M Khenfouch, B M Mothudi, M Maaza
Silver nanoparticles (AgNPs) grown on a three dimensional (3d) graphene networks (GNs) has been successfully prepared by an efficient and rapid microwave-assisted growth process to form GNs/AgNPs nanocomposite electrode materials for supercapacitor application. The 3d nature of the used GNs offers a unique architecture, which creates an efficient conduction networks and maximum utilization of space and interface, and acts as a conductive layer for the deposited AgNPs. The electrochemical performances of the fabricated electrode were evaluated by cyclic voltammetry (CV), galvanostatic charge/discharge and electrochemical impedance spectroscopy (EIS) tests...
January 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28088308/effect-of-various-polishing-systems-on-the-surface-roughness-and-phase-transformation-of-zirconia-and-the-durability-of-the-polishing-systems
#4
Chan Park, Mong-Sook Vang, Sang-Won Park, Hyun-Pil Lim
STATEMENT OF PROBLEM: Although many systems are used to polish zirconia, a comparison of the performance of zirconia and feldspathic porcelain polishing systems is lacking. PURPOSE: The purpose of this in vitro study was to compare the effects of 3 polishing systems on surface roughness, zirconia phase transformation, and durability of the polishing systems when applied to zirconia and feldspathic porcelain. MATERIAL AND METHODS: Three polishing systems were evaluated: Z1, a zirconia polishing system; Z2, a zirconia polishing system, and F1, a feldspathic porcelain polishing system...
January 11, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28088304/mechanical-biomarkers-of-medial-compartment-knee-osteoarthritis-diagnosis-and-severity-grading-discovery-phase
#5
Neila Mezghani, Youssef Ouakrim, Alexandre Fuentes, Amar Mitiche, Nicola Hagemeister, Pascal-André Vendittoli, Jacques A de Guise
OBJECTIVE: To investigate, as a discovery phase, if 3D knee kinematics assessment parameters can serve as mechanical biomarkers, more specifically as diagnostic biomarker and burden of disease biomarkers, as defined in the Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic classification scheme for osteoarthritis (OA) (Altman et al., 1986). These biomarkers consist of a set of biomechanical parameters discerned from 3D knee kinematic patterns, namely, flexion/extension, abduction/adduction, and tibial internal/external rotation measurements, during gait recording...
December 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28088129/in-vitro-eye-irritation-testing-using-the-open-source-reconstructed-hemicornea-a-ring-trial
#6
Karsten R Mewes, Maria Engelke, Michaela Zorn-Kruppa, Melinda Bartok, Rashmi Tandon, Johanna M Brandner, Dirk Petersohn
Aim of the present ring trial was to prove whether two new methodological approaches for the in vitro classification of eye irritating chemicals can be reliably transferred from the developers' laboratories to other sites.Both test methods are based on the well-established open source reconstructed 3D hemicornea models. In the first approach, the initial depth of injury in the hemicornea model after chemical treatment is derived from the quantitative analysis of histological sections. In the second approach tissue viability, as a measure for corneal damage after chemical treatment, is analyzed separately for epithelium and stroma of the hemicornea model...
January 14, 2017: ALTEX
https://www.readbyqxmd.com/read/28088120/3d-architecture-of-a-graphene-comoo4-composite-for-asymmetric-supercapacitors-usable-at-various-temperatures
#7
Yaru Jiang, Xin Zheng, Xiaoqin Yan, Yong Li, Xuan Zhao, Yue Zhang
Designing and optimizing the electrode materials and studying the electrochemical performance or cycle life of the supercapacitor under different working conditions are crucial to its practical application. Herein, we proposed a rational design of 3D-graphene/CoMoO4 nanoplates by a facile two-step hydrothermal method. Owing to the high electron transfer rate of graphene and the high activity of the CoMoO4 nanoplates, the three-dimensional electrode architectures achieved remarkable electrochemical performances with high areal specific capacitance (1255...
January 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28088094/organ-on-a-chip-for-assessing-environmental-toxicants
#8
REVIEW
Soohee Cho, Jeong-Yeol Yoon
Man-made xenobiotics, whose potential toxicological effects are not fully understood, are oversaturating the already-contaminated environment. Due to the rate of toxicant accumulation, unmanaged disposal, and unknown adverse effects to the environment and the human population, there is a crucial need to screen for environmental toxicants. Animal models and in vitro models are ineffective models in predicting in vivo responses due to inter-species difference and/or lack of physiologically-relevant 3D tissue environment...
January 11, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28088072/microstructural-mechanical-and-corrosion-characteristics-of-heat-treated-mg-1-2zn-0-5ca-wt-alloy-for-use-as-resorbable-bone-fixation-material
#9
Hamdy Ibrahim, Andrew D Klarner, Behrang Poorganji, David Dean, Alan A Luo, Mohammad Elahinia
Mg-Zn-Ca alloys have grabbed most of the recent attention in research attempting to develop an Mg alloy for bone fixation devices due to their superior biocompatibility. However, early resorption and insufficient strength remain the main problems that hinder their use. Heat treatment has previously been thoroughly studied as a post-shaping process, especially after the fabrication of complex parts (e.g. porous structures) by 3D-printing or powder metallurgy. In this work, the effect of heat treatment on Mg-1...
January 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28087602/novel-application-of-3d-contrast-enhanced-cmr-to-define-fibrotic-structure-of-the-human-sinoatrial-node-in-vivo
#10
Thomas A Csepe, Jichao Zhao, Lidiya V Sul, Yufeng Wang, Brian J Hansen, Ning Li, Anthony J Ignozzi, Anna Bratasz, Kimerly A Powell, Ahmet Kilic, Peter J Mohler, Paul M L Janssen, John D Hummel, Orlando P Simonetti, Vadim V Fedorov
AIMS: The adult human sinoatrial node (SAN) has a specialized fibrotic intramural structure (35-55% fibrotic tissue) that provides mechanical and electrical protection from the surrounding atria. We hypothesize that late gadolinium-enhanced cardiovascular magnetic resonance (LGE-CMR) can be applied to define the fibrotic human SAN structure in vivo. METHODS AND RESULTS: LGE-CMR atrial scans of healthy volunteers (n olu, 23-52 y.o.) using a 3 Tesla magnetic resonance imaging system with a spatial resolution of 1...
January 13, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28087551/cost-effectiveness-of-superficial-femoral-artery-endovascular-interventions-in-the-uk-and-germany-a-modelling-study
#11
Benjamin C Kearns, Steven M Thomas
OBJECTIVES: To assess the lifetime costs and cost-effectiveness of 5 endovascular interventions to treat superficial femoral arterial disease. DESIGN: A model-based health economic evaluation. An existing decision analytical model was used, with updated effectiveness data taken from the literature, and updated costs based on purchasing prices. SETTING: UK and German healthcare perspectives were considered. PARTICIPANTS: Patients with intermittent claudication of the femoropopliteal arteries eligible for endovascular treatment...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28087494/porcine-kobuvirus-1-in-healthy-and-diarrheic-pigs-genetic-detection-and-characterization-of-virus-and-co-infection-with-rotavirus-a
#12
Anna Jackova, Ivan Sliz, Rene Mandelik, Slavomira Salamunova, Jaroslav Novotny, Mariana Kolesarova, Michaela Vlasakova, Stefan Vilcek
The porcine kobuvirus 1 (PKV-1) is believed to be an enteric virus. To investigate the prevalence of PKV-1 in pigs, virus was detected by RT-PCR in rectal swabs originating from 414 healthy and diarrheic pigs of different age categories on farms in Slovakia. Among all ages of animals, PKV-1 was detected equally in diarrheic (63.8%) and clinically healthy (62.9%) pigs. PKV-1 was more often detected in diarrheic (74.6%) than in healthy (64.4%) suckling piglets (<28days) but data was not statistically significant...
January 10, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28087487/bioprinting-for-vascular-and-vascularized-tissue-biofabrication
#13
REVIEW
Pallab Datta, Bugra Ayan, Ibrahim T Ozbolat
: Bioprinting is a promising technology to fabricate design-specific tissue constructs due to its ability to create complex, heterocellular structures with anatomical precision. Bioprinting enables the deposition of various biologics including growth factors, cells, genes, neo-tissues and extra-cellular matrix-like hydrogels. Benefits of bioprinting have started to make a mark in the fields of tissue engineering, regenerative medicine and pharmaceutics. Specifically, in the field of tissue engineering, the creation of vascularized tissue constructs has remained a principal challenge till date...
January 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28087483/cell-number-per-spheroid-and-electrical-conductivity-of-nanowires-influence-the-function-of-silicon-nanowired-human-cardiac-spheroids
#14
Yu Tan, Dylan Richards, Robert C Coyle, Jenny Yao, Ruoyu Xu, Wenyu Gou, Hongjun Wang, Donald R Menick, Bozhi Tian, Ying Mei
: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide an unlimited cell source to treat cardiovascular diseases, the leading cause of death worldwide. However, current hiPSC-CMs retain an immature phenotype that leads to difficulties for integration with adult myocardium after transplantation. To address this, we recently utilized electrically conductive silicon nanowires (e-SiNWs) to facilitate self-assembly of hiPSC-CMs to form nanowired hiPSC cardiac spheroids...
January 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28087395/lumbar-spinal-muscles-and-spinal-canal-study-by-mri-three-dimensional-reconstruction-in-adult-lumbar-spinal-stenosis
#15
Louis Boissière, Bertrand Moal, Olivier Gille, Elise De-Roquefeuil, Muriel Durieux, Ibrahim Obeid, Vincent Dousset, Jean-Marc Vital, Wafa Skalli
BACKGROUND: Lumbar spinal stenosis is degenerative disc disease most common manifestation. If stenosis degree seems poorly related to symptom severity, lumbar muscles role is recognized. Many studies report imaging methods, to analyze muscle volumes and fat infiltration (FI), but remain limited due to the difficulty to represent entire muscle volume variability. Recently a 3D muscle reconstruction protocol (using the deformation of a parametric specific object method (DPSO) and three point Dixon images) was reported...
January 10, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28086998/evaluation-of-artifacts-generated-by-zirconium-implants-in-cone-beam-computed-tomography-images
#16
Taruska Ventorini Vasconcelos, Boulos B Bechara, Clyde Alex McMahan, Deborah Queiroz Freitas, Marcel Noujeim
OBJECTIVE: To evaluate zirconium implant artifact production in cone beam computed tomography images obtained with different protocols. STUDY DESIGN: One zirconium implant was inserted in an edentulous mandible. Twenty scans were acquired with a ProMax 3D unit (Planmeca Oy, Helsinki, Finland), with acquisition settings ranging from 70 to 90 peak kilovoltage (kVp) and voxel sizes of 0.32 and 0.16 mm. A metal artifact reduction (MAR) tool was activated in half of the scans...
February 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28086965/probabilistic-liver-atlas-construction
#17
Esther Dura, Juan Domingo, Guillermo Ayala, Luis Marti-Bonmati, E Goceri
BACKGROUND: Anatomical atlases are 3D volumes or shapes representing an organ or structure of the human body. They contain either the prototypical shape of the object of interest together with other shapes representing its statistical variations (statistical atlas) or a probability map of belonging to the object (probabilistic atlas). Probabilistic atlases are mostly built with simple estimations only involving the data at each spatial location. RESULTS: A new method for probabilistic atlas construction that uses a generalized linear model is proposed...
January 13, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28086779/the-effect-of-electrical-conductivity-of-myocardium-on-cardiac-pumping-efficacy-a-computational-study
#18
Ana Rahma Yuniarti, Ki Moo Lim
BACKGROUND AND AIMS: The existence of non-excitable cells in the myocardium leads to the increasing conduction non-uniformity and decreasing myocardial electrical conductivity. Slowed myocardial conduction velocity (MCV) believed to enhance the probability of cardiac arryhthmia and alter the cardiac mechanical pumping efficacy, even in sinus rhythm. Though several studies on the correlation between MCV and cardiac electrical instabilities exist, there has been no study concerning correlation or causality between MCV and cardiac mechanical pumping efficacy, due to the limitation in clinical methods to document and evaluate cardiac mechanical responses directly...
January 10, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28081453/intertypic-recombination-of-human-parechovirus-4-isolated-from-infants-with-sepsis-like-disease
#19
Pekka Kolehmainen, Anu Siponen, Teemu Smura, Hannimari Kallio-Kokko, Olli Vapalahti, Anne Jääskeläinen, Sisko Tauriainen
BACKGROUND: Human parechoviruses (HPeVs) (family Picornaviridae), are common pathogens in young children. Despite their high prevalence, research on their genetic identity, diversity and evolution have remained scarce. OBJECTIVES: Complete coding regions of three previously reported HPeV-4 isolates from Finnish children with sepsis-like disease were sequenced in order to elucidate the phylogenetic relationships and potential recombination events during the evolution of these isolates...
January 3, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28081113/reciprocity-relation-for-the-vector-radiative-transport-equation-and-its-application-to-diffuse-optical-tomography-with-polarized-light
#20
Ugo Tricoli, Callum M Macdonald, Anabela Da Silva, Vadim A Markel
We derive a reciprocity relation for the 3D vector radiative transport equation that describes propagation of polarized light in multiple-scattering media. We then show how this result, together with translational invariance of a plane-parallel sample, can be used to efficiently compute the sensitivity kernel of diffuse optical tomography by Monte Carlo simulations. Numerical examples of polarization-selective sensitivity kernels are given.
January 15, 2017: Optics Letters
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