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Kalliopi N Manola, Fotios Panitsas, Sophia Polychronopoulou, Aggeliki Daraki, Maria Karakosta, Cryssa Stavropoulou, Georgia Avgerinou, Emmanuel Hatzipantelis, Gabriel Pantelias, Constantina Sambani, Maria Pagoni
The whole spectrum of chromosomal abnormalities and their prognostic significance in children and adolescents with acute myeloid leukemia (AML) has not been fully elucidated yet, although a considerable amount of knowledge has been gained recently. Moreover, the incidence and prognostic impact of monosomal karyotypes (MKs), which are new cytogenetic categories reported recently in adults with AML, are currently unknown for childhood and adolescent AML. In this study, we investigated the cytogenetic and clinical characteristics of 140 children and adolescents (≤21 y) with AML, and correlated their cytogenetic features with both the clinical characteristics and outcomes of our patient cohort...
March 2013: Cancer Genetics
Alejandro Lazo-Langner, Jie Xu
No abstract text is available yet for this article.
November 29, 2012: Blood
Hee Nam Kim, Yeo-Kyeoung Kim, Il-Kwon Lee, Deok-Hwan Yang, Je-Jung Lee, Min-Ho Shin, Kyeong-Soo Park, Jin-Su Choi, Moo Rim Park, Deog Yeon Jo, Jong Ho Won, Jae-Yong Kwak, Hyeoung-Joon Kim
Several genetic polymorphisms in the genes coding folate-metabolizing enzymes have been associated with susceptibility to hematology malignancies. We conducted a Korean population-based case-control study to examine the relationship between the polymorphisms of folate-metabolizing enzymes and the risk of AML (acute myelogenous leukemia), CML (chronic myelogenous leukemia), MDS (myelodyspastic syndrome), and ALL (acute lymphoblastc leukemia). The MTHFR 677TT genotype was associated with an increased risk for ALL (odds ratios (OR)=1...
January 2009: Leukemia Research
R N Shishina, D A Shmarov, I A Bykova, G I Kozinets
The proliferative activity of bone marrow cells was studied by flow cytofluorometry in 8 patients with aplastic anemia (AA), 6 with myelodyspastic syndrome (MDS), and 26 normal subjects aged 21-40 years. The myelokaryocyte proliferation was inhibited at the G0-1 stages of cell cycle, the number of cells in the S phase was decreased, and the coefficient of variations cV of DNA cytofluorometry values were increased in AA patients in comparison with the norm. By contrast, in MDS patients the number of cells in the G0-1 phase was decreased and that of cells in the S phase increased in comparison with the norm and with AA patients; cV was increased...
February 2000: Klinicheskaia Laboratornaia Diagnostika
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