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https://www.readbyqxmd.com/read/29776313/bioinspired-thermoresponsive-nanoscaled-coatings-tailor-made-polymer-brushes-with-bioconjugated-arginine-glycine-aspartic-acid-peptides
#1
Ulla König, Evmorfia Psarra, Olga Guskova, Eva Bittrich, Klaus-Jochen Eichhorn, Martin Müller, Petra B Welzel, Manfred Stamm, Petra Uhlmann
The development of bioengineered surface coatings with stimuli-responsive properties is beneficial for a number of biomedical applications. Environmentally responsive and switchable polymer brush systems have a great potential to create such smart biointerfaces. This study focuses on the bioconjugation of cell-instructive peptides, containing the arginine-glycine-aspartic acid tripeptide sequence (RGD motif), onto well-defined polymer brush films. Herein, the highly tailored end-grafted homo polymer brushes are either composed of the polyelectrolyte poly(acrylic) acid (PAA), providing the reactive carboxyl functionalities, or of the temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm)...
May 18, 2018: Biointerphases
https://www.readbyqxmd.com/read/29774482/the-effect-of-subclinical-varicocele-on-pregnancy-rates-and-semen-parameters-a-systematic-review-and-meta-analysis
#2
REVIEW
Taylor P Kohn, Samuel J Ohlander, Jake S Jacob, Tina M Griffin, Larry I Lipshultz, Alexander W Pastuszak
PURPOSE OF REVIEW: Current guidelines recommend against surgical repair of subclinical varicoceles (SCVs) for infertility; several studies demonstrate mixed fertility results after SCV correction. To determine whether surgical correction of SCV improves semen parameters and/or reproductive outcomes, we performed a systematic review and meta-analysis. Seven biomedical literature databases were searched through January 2018 for studies that assessed reproductive outcomes and/or change in semen parameters in men with corrected SCV compared to either (1) uncorrected SCV or (2) corrected clinical varicocele...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29774150/the-effect-of-off-hours-hospital-admission-on-mortality-and-clinical-outcomes-for-patients-with-upper-gastrointestinal-hemorrhage-a-systematic-review-and-meta-analysis-of-20-cohorts
#3
Xian Feng Xia, Philip Wai Yan Chiu, Kelvin Kam Fai Tsoi, Francis Ka Leung Chan, Joseph Jao Yiu Sung, James Yun Wong Lau
Objective: The objective of this article is to evaluate the relationship between off-hours hospital admission (weekends, public holidays or nighttime) and mortality for upper gastrointestinal hemorrhage (UGIH). Methods: Medline, Embase, Scopus, and the Chinese Biomedical Literature were searched through December 2016 to identify eligible records for inclusion in this meta-analysis. A random-effects model was applied. Results: Twenty cohort studies were included for analysis...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29773174/in-vivo-bio-distribution-clearance-and-toxicity-assessment-of-biogenic-silver-and-gold-nanoparticles-synthesized-from-abutilon-indicum-in-wistar-rats
#4
Rani Mata, Jayachandra Reddy Nakkala, Varshney Khub Chandra, Kumar Raja, Sudha Rani Sadras
This study reports the bio-distribution and clearance of Abutilon indicum silver and gold nanoparticles (AIAgNPs and AIAuNPs) in Wistar rats. Rats in different groups were orally administered with 5 and 10 mg/Kg BW of AIAgNPs and AIAuNPs (size 1-25 nm) for 28 days and few were maintained until 58 days of washout period. Serum biochemical parameters were not changed significantly at both doses of AIAuNPs and at lower concentration of AIAgNPs. But, with 10 mg/Kg BW of AIAgNPs rats showed elevated levels of AST, ALP and ALT on day 29, however, these levels were restored to normal after washout period...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29772600/an-accurate-bacterial-dna-quantification-assay-for-hts-library-preparation-of-human-biological-samples
#5
Sarah Seashols-Williams, Raquel Green, Denise Wohlfahrt, Angela Brand, Antonio Limjuco Tan-Torres, Francy Nogales, J Paul Brooks, Baneshwar Singh
Sequencing and classification of microbial taxa within forensically relevant biological fluids has the potential for applications in the forensic science and biomedical fields. The quantity of bacterial DNA from human samples is currently estimated based on quantity of total DNA isolated. This method can miscalculate bacterial DNA quantity due to the mixed nature of the sample, and consequently library preparation is often unreliable. We developed an assay that can accurately and specifically quantify bacterial DNA within a mixed sample for reliable 16S ribosomal DNA (16S rDNA) library preparation and high throughput sequencing (HTS)...
May 17, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29772348/biosafety-stability-and-osteogenic-activity-of-novel-implants-made-of-zr-70-ni-16-cu-6-al-8-bulk-metallic-glass-for-biomedical-application
#6
Hiroto Ida, Masahiro Seiryu, Nobuo Takeshita, Masanari Iwasaki, Yoshihiko Yokoyama, Yusuke Tsutsumi, Etsuko Ikeda, Satoshi Sasaki, Shunro Miyashita, Shutaro Sasaki, Tomohiro Fukunaga, Toru Deguchi, Teruko Takano-Yamamoto
Superior mechanical and chemical properties of Zr70 Ni16 Cu6 Al8 bulk metallic glass (BMG) demonstrate its promise as a novel biomaterial for fabrication of implants. The aim of the present study was to validate mechanical, chemical, and biological properties of Zr70 Ni16 Cu6 Al8 BMG through comparison with titanium (Ti). Our data indicated higher tensile strength, lower Young's modulus, and reduced metal ion release of Zr70 Ni16 Cu6 Al8 BMG compared with Ti. Biosafety of bone marrow mesenchymal cells on Zr70 Ni16 Cu6 Al8 BMG was comparable to that of Ti...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29772338/hyaluronic-acid-an-efficient-biomacromolecule-for-treatment-of-inflammatory-skin-and-joint-diseases-a-review-of-recent-developments-and-critical-appraisal-of-preclinical-and-clinical-investigations
#7
REVIEW
Li Hui Chen, Jian Feng Xue, Zhi Yong Zheng, Muhammad Shuhaidi, Hnin Ei Thu, Zahid Hussain
Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. A thorough analysis of the literature revealed that HA based formulations (i...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29771925/in-vitro-and-in-vivo-biological-performance-of-porous-ti-alloys-prepared-by-powder-metallurgy
#8
Renata Falchete do Prado, Gabriela Campos Esteves, Evelyn Luzia De Souza Santos, Daiane Acácia Griti Bueno, Carlos Alberto Alves Cairo, Luis Gustavo Oliveira De Vasconcellos, Renata Silveira Sagnori, Fernanda Bastos Pereira Tessarin, Felipe Eduardo Oliveira, Luciane Dias De Oliveira, Maria Fernanda Lima Villaça-Carvalho, Vinicius André Rodrigues Henriques, Yasmin Rodarte Carvalho, Luana Marotta Reis De Vasconcellos
Titanium (Ti) and Ti-6 Aluminium-4 Vanadium alloys are the most common materials in implants composition but β type alloys are promising biomaterials because they present better mechanical properties. Besides the composition of biomaterial, many factors influence the performance of the biomaterial. For example, porous surface may modify the functional cellular response and accelerate osseointegration. This paper presents in vitro and in vivo evaluations of powder metallurgy-processed porous samples composed by different titanium alloys and pure Ti, aiming to show their potential for biomedical applications...
2018: PloS One
https://www.readbyqxmd.com/read/29771314/use-of-bibloc-and-monobloc-oral-appliances-in-obstructive-sleep-apnoea-a-multicentre-randomized-blinded-parallel-group-equivalence-trial
#9
Göran Isacsson, Eva Nohlert, Anette M C Fransson, Anna Bornefalk-Hermansson, Eva Wiman Eriksson, Eva Ortlieb, Livia Trepp, Anna Avdelius, Magnus Sturebrand, Clara Fodor, Thomas List, Mohamad Schumann, Åke Tegelberg
Background: The clinical benefit of bibloc over monobloc appliances in treating obstructive sleep apnoea (OSA) has not been evaluated in randomized trials. We hypothesized that the two types of appliances are equally effective in treating OSA. Objective: To compare the efficacy of monobloc versus bibloc appliances in a short-term perspective. Patients and methods: In this multicentre, randomized, blinded, controlled, parallel-group equivalence trial, patients with OSA were randomly assigned to use either a bibloc or a monobloc appliance...
May 16, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29769600/x-ray-based-virtual-histology-allows-guided-sectioning-of-heavy-ion-stained-murine-lungs-for-histological-analysis
#10
Jonas Albers, M Andrea Markus, Frauke Alves, Christian Dullin
Examination of histological or immunohistochemically stained 2D sections of embedded tissue is one of the most frequently used tools in biomedical research and clinical routine. Since to date, targeted sectioning of specific regions of interest (ROI) in the sample is not possible, we aimed at developing a guided sectioning approach based on x-ray 3D virtual histology for heavy ion stained murine lung samples. For this purpose, we increased the contrast to noise ratio of a standard benchtop microCT by 5-10-fold using free-propagation phase contrast imaging and thus substantially improved image quality...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769172/privacy-preserving-predictive-modeling-harmonization-of-contextual-embeddings-from-different-sources
#11
Yingxiang Huang, Junghye Lee, Shuang Wang, Jimeng Sun, Hongfang Liu, Xiaoqian Jiang
BACKGROUND: Data sharing has been a big challenge in biomedical informatics because of privacy concerns. Contextual embedding models have demonstrated a very strong representative capability to describe medical concepts (and their context), and they have shown promise as an alternative way to support deep-learning applications without the need to disclose original data. However, contextual embedding models acquired from individual hospitals cannot be directly combined because their embedding spaces are different, and naive pooling renders combined embeddings useless...
May 16, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29768960/contested-understandings-of-recovery-in-mental-health
#12
Rhiannah McCabe, Richard Whittington, Laura Cramond, Elizabeth Perkins
BACKGROUND: The concept of recovery is contested throughout the existing literature and in mental health services. Little research exists that gives voice to service user perspectives of recovery. AIM: This paper explores how service users in two recovery oriented services run by the National Health Service in North West England talked about recovery and what it meant to them. METHOD: 14 service users accessing these services took part in semi-structured qualitative interviews focusing on the concept of recovery...
May 17, 2018: Journal of Mental Health
https://www.readbyqxmd.com/read/29768607/-the-medicalization-of-life-hybrids-against-the-dichotomy-nature-culture
#13
Anahi Sy
This paper aims to analyze the process of medicalization in current societies, starting from the description of the way in which medicine gradually appropriated various aspects of everyday life that were once part of the life cycle of people. At the theoretical level, we are based on authors such as Descola and Latour, who problematize the dichotomy between Nature and Culture, and propose the need to think from a superior episteme. Methodologically, this theoretical proposal enables an analysis of the medicalization that can illuminate what is hidden in the discourse and biomedical practices: the sociocultural, political and economic processes that are part of these "objects" of Medicine...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29768327/survival-benefit-of-neoadjuvant-chemotherapy-for-resectable-breast-cancer-a-meta-analysis
#14
Yan Chen, Xiu-E Shi, Jin-Hui Tian, Xu-Juan Yang, Yong-Feng Wang, Ke-Hu Yang
BACKGROUND: Neoadjuvant chemotherapy (NAC) increases breast conservation rates in patients with resectable breast cancer at the associated cost of higher locoregional recurrence rates; however, the magnitude of the survival benefits of NAC for these patients remains undefined. Therefore, we aimed to clarify the survival benefit of NAC versus postoperative chemotherapy by conducting an updated meta-analysis of randomized clinical trials (RCTs). METHODS: The authors searched the Cochrane Library, PubMed, Embase, Web of Science, Chinese biomedical literature database, and Chinese Scientific Journals full-text database from their inception to December 2016...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29768323/efficacy-and-risks-of-anticoagulation-for-cerebral-venous-thrombosis
#15
Weilin Xu, Liansheng Gao, Tao Li, Anwen Shao, Jianmin Zhang
BACKGROUND AND PURPOSE: Cerebral venous thrombosis (CVT) is a rare but life-threatening disease. Timely and proper treatments are the keys in saving patients' life and preventing from permanent neurological deficits. We performed this network meta-analysis to evaluate the role of anticoagulation in CVT, especially for the patients accompanied with hemorrhagic stroke. METHODS: PubMed, Embase, Web of Science, Cochrane Database, and Chinese Biomedical (CBM) databases were searched comprehensively to select eligible articles (up to 30 June 2017)...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29768230/screening-the-uv-blocking-and-antimicrobial-properties-of-herbal-nanoparticles-prepared-from-aloe-vera-leaves-for-textile-applications
#16
Karthik Subramani, Balu Kolathupalayam Shanmugam, Suriyaprabha Rangaraj, Manivasakan Palanisamy, Prabu Periasamy, Rajendran Venkatachalam
Nanomaterials play a vital role in textile industries due to their unique properties and applications. There is an increase in the use of nanoscale phyto products in textiles to control the bacterial infection in fabrics. Here, natural herbal nanoparticles of different sizes were prepared from shade-dried Aloe vera plant leaves using ball milling technique without any additives. The amorphous herbal A. vera nanoparticles possess an average particle size of 40 ± 2 nm and UV-absorption maximum at 269 nm...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29767910/preparation-for-motherhood-during-pregnancy-a-concept-analysis
#17
Jhon Henry Osorio-Castaño, Gloria Carvajal-Carrascal, María Rodríguez-Gázquez
OBJECTIVES: This work sought to identify the attributes of the concept of preparation for motherhood during pregnancy. METHODS: Concept analysis with the method by Walker and Avant, which conducted a literature review in databases and other sources. Inclusion criteria were defined and a database was created with the articles included for the analysis. The information was integrated, responding to the eight steps proposed in the method. RESULTS: The concept of preparation for motherhood during pregnancy is defined as an intermediate process of active and conscious participation defined by the cultural, social, and historical contexts, which favor lifestyle changes to optimize health and whose attributes are classified into physical and psychological preparation...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29767347/enhanced-plasmonic-biosensors-of-hybrid-gold-nanoparticle-graphene-oxide-based-label-free-immunoassay
#18
Nan-Fu Chiu, Chi-Chu Chen, Cheng-Du Yang, Yu-Sheng Kao, Wei-Ren Wu
In this study, we propose a modified gold nanoparticle-graphene oxide sheet (AuNP-GO) nanocomposite to detect two different interactions between proteins and hybrid nanocomposites for use in biomedical applications. GO sheets have high bioaffinity, which facilitates the attachment of biomolecules to carboxyl groups and has led to its use in the development of sensing mechanisms. When GO sheets are decorated with AuNPs, they introduce localized surface plasmon resonance (LSPR) in the resonance energy transfer of spectral changes...
May 16, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29766780/soft-biomaterial-based-nanocrystal-in-pharmaceutical
#19
Nandi Chen, Taojunfeng Su, Zhe Cheng, Feifei An
BACKGROUND AND OBJECTIVE: Bio-soft material, a class of derivatives of the natural or synthetic material, is getting more and more prevalent in biomedical researches and applications due to the advantages such as in-vivo biodegradation, good water solubility and designable targeting ability. With the presence of bio-soft materials, the drug nanocrystal can be easily generated and aggregated in a feasible process. Given the promising application of the bio-soft material in biological and chemical research, it is valuable to discuss the crucial step in designing bio-soft materials and analyze the emerging properties of bio-soft materials...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29763771/influence-of-ph-on-wet-synthesis-of-silver-decorated-hydroxyapatite-nanopowder
#20
P Narendran, Archana Rajendran, Mirna Garhnayak, Lokanath Garhnayak, J Nivedhitha, K Chandra Devi, Deepak K Pattanayak
Here, effect of solution pH on precipitation of silver decorated hydroxyapatite (Ag-HAp) nano powder during its wet-synthesis was systematically studied. XRD pattern of Ag-HAp nano powder synthesised at pH ranging from 5 to 10 shows that calcium hydrogen phosphate was formed as dominating phase when the solution pH was between 5 and 9 and this phase was gradually transformed into a stable HAp above pH 9. A quantitative analysis of silver amount in Ag-HAp nano powder synthesised at different pH showed that silver can be precipitated to its maximum amount at pH 8 and the further addition of ammonia leads to the formation of a silver-ammonium complex, thereby remaining in the solution...
April 22, 2018: Colloids and Surfaces. B, Biointerfaces
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