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https://www.readbyqxmd.com/read/29333931/hyperspectral-imaging-of-tissue-perfusion-and-oxygenation-in-wounds-assessing-the-impact-of-a-micro-capillary-dressing
#1
Thomas Wild, Markus Becker, Jochen Winter, Nicole Schuhschenk, Georg Daeschlein, Frank Siemers
OBJECTIVE: Experimental tests of non-invasive multi- or hyperspectral imaging (HSI) systems reveal the high potential of support for medical diagnostic purposes and scientific biomedical analysis. Until now the use of HSI technologies for medical applications was limited by complex and overly sophisticated systems. We present a new and compact HSI-camera that could be used in normal clinical practice. METHOD: We assessed the use of the HSI system on the hands of 10 healthy volunteers, looking at control parameters, and those following venous occlusion, arterial occlusion and reperfusion, including tissue oxygenation, tissue haemoglobin index, perfusion in 4-6mm depth=near infrared spectroscopy (NIR), and tissue water index...
January 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29333051/therapeutic-significance-of-loligo-vulgaris-lamarck-1798-ink-extract-a-biomedical-approach
#2
Sri Kumaran Nadarajah, Radha Vijayaraj, Jayaprakashvel Mani
Background: The squid ink extract is well known for its biomedical properties. Objective: In this study, squid Loligo vulgaris was collected from Tuticorin costal water, Bay of Bengal, India. Materials and Methods: Proximate composition of the crude squid ink was studied and found to have protein as the major component over lipid and carbohydrates. Further, bioactive fractions of squid ink were extracted with ethanol, and therapeutic applications such as hemolytic, antioxidant, antimicrobial, and in vitro anti-inflammatory properties were analyzed using standard methods...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332986/fadttster-accelerating-hypothesis-testing-with-functional-analysis-of-diffusion-tensor-tract-statistics
#3
Jean Noel, Juan C Prieto, Martin Styner
Functional Analysis of Diffusion Tensor Tract Statistics (FADTTS) is a toolbox for analysis of white matter (WM) fiber tracts. It allows associating diffusion properties along major WM bundles with a set of covariates of interest, such as age, diagnostic status and gender, and the structure of the variability of these WM tract properties. However, to use this toolbox, a user must have an intermediate knowledge in scripting languages (MATLAB). FADTTSter was created to overcome this issue and make the statistical analysis accessible to any non-technical researcher...
March 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29332985/civility-cloud-based-interactive-visualization-of-tractography-brain-connectome
#4
Danaële Puechmaille, Martin Styner, Juan C Prieto
Cloud based Interactive Visualization of Tractography Brain Connectome (CIVILITY) is an interactive visualization tool of brain connectome in the cloud. This application submits tasks to remote computing grids were the CIVILITY-tractography pipeline is deployed. The application will list the running tasks for the user and once a task is completed the brain connectome is visualized using Hierarchical Edge Bundling. The analysis pipeline uses FSL tools (bedpostx and probtrackx2) to generate a triangular matrix indicating the connectivity strength between different regions in the brain...
March 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29331360/fully-automated-segmentation-of-polycystic-kidneys-from-noncontrast-computed-tomography-a-feasibility-study-and-preliminary-results
#5
Dario Turco, Maddalena Valinoti, Eva Maria Martin, Carlo Tagliaferri, Francesco Scolari, Cristiana Corsi
RATIONALE AND OBJECTIVES: Total kidney volume is an important biomarker for the evaluation of autosomal dominant polycystic kidney disease progression. In this study, we present a novel approach for automated segmentation of polycystic kidneys from non-contrast-enhanced computed tomography (CT) images. MATERIALS AND METHODS: Non-contrast-enhanced CT images were acquired from 21 patients with a diagnosis of autosomal dominant polycystic kidney disease. Kidney volumes obtained from the fully automated method were compared to volumes obtained by manual segmentation and evaluated using linear regression and Bland-Altman analyses...
January 10, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29330464/eltrombopag-versus-romiplostim-in-treatment-of-children-with-persistent-or-chronic-immune-thrombocytopenia-a-systematic-review-incorporating-an-indirect-comparison-meta-analysis
#6
Jiaxing Zhang, Yi Liang, Yuan Ai, Xiaosi Li, Juan Xie, Youping Li, Wenyi Zheng, Rui He
In absence of direct comparison, we conducted an indirect-comparison meta-analysis to evaluate the efficacy and safety of thrombopoietin-receptor agonists(TPO-RAs) in treatment of pediatric persistent or chronic immune thrombocytopenia(ITP). PubMed, Embase, Cochrane Library, Clinical Trials.gov, China National Knowledge Infrastructure, and Chinese Biomedical Literature Database were searched from their earliest records to May 2017. Randomized controlled trials comparing the TPO-RAs with placebo in pediatric ITP were included...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329648/preparation-and-physicochemical-characterization-of-t-oa-plga-microspheres
#7
Jing Fu, Xiao-Xu Dong, Zu-Ping Zeng, Xing-Bin Yin, Fa-Wei Li, Jian Ni
As the carrier of water-insoluble drugs, microspheres can play a role in increasing solubility and delaying releasing essence. The objective of this study was to improve the solubility and to delay the release of a newly discovered antitumor compound 3β-hydroxyolea-12-en-28-oic acid-3, 5, 6-trimethylpyrazin-2-methyl ester (T-OA). Early-stage preparation discovery concept (EPDC) was employed in the present study. The preparation, physicochemical characterization, and drug release properties of PLGA microspheres were evaluated...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329592/the-extensible-ontology-development-xod-principles-and-tool-implementation-to-support-ontology-interoperability
#8
REVIEW
Yongqun He, Zuoshuang Xiang, Jie Zheng, Yu Lin, James A Overton, Edison Ong
Ontologies are critical to data/metadata and knowledge standardization, sharing, and analysis. With hundreds of biological and biomedical ontologies developed, it has become critical to ensure ontology interoperability and the usage of interoperable ontologies for standardized data representation and integration. The suite of web-based Ontoanimal tools (e.g., Ontofox, Ontorat, and Ontobee) support different aspects of extensible ontology development. By summarizing the common features of Ontoanimal and other similar tools, we identified and proposed an "eXtensible Ontology Development" (XOD) strategy and its associated four principles...
January 12, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29328304/optofluidic-refractive-index-sensors-employing-bent-waveguide-structures-for-low-cost-rapid-chemical-and-biomedical-sensing
#9
I-Chen Liu, Pin-Chuan Chen, Lai-Kwan Chau, Guo-En Chang
We propose and develop an intensity-detection-based refractive-index (RI) sensor for low-cost, rapid RI sensing. The sensor is composed of a polymer bent ridge waveguide (BRWG) structure on a low-cost glass substrate and is integrated with a microfluidic channel. Different-RI solutions flowing through the BRWG sensing region induce output optical power variations caused by optical bend losses, enabling simple and real-time RI detection. Additionally, the sensors are fabricated using rapid and cost-effective vacuum-less processes, attaining the low cost and high throughput required for mass production...
January 8, 2018: Optics Express
https://www.readbyqxmd.com/read/29327409/cultural-aspects-of-pain-a-study-of-indian-asian-women-in-the-uk
#10
Stephanie Holt, Jackie Waterfield
OBJECTIVES: Culture and ethnicity are acknowledged as important factors in the context of the biopsychosocial model. They may contribute to explaining the experience of pain, therapeutic encounters within healthcare, and the strategies that individuals use to cope with pain. The present study explored these issues in a sample of Indian Asian women in the UK. METHODS: Based on a phenomenological approach, 17 women participated in five semi-structured group interviews...
January 12, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29327398/ways-of-knowing-on-the-internet-a-qualitative-review-of-cancer-websites-from-a-critical-nursing-perspective
#11
Kristen R Haase, Roanne T Thomas, Wendy Gifford, Lorraine F Holtslander
People diagnosed with cancer typically want information from their doctor or nurse. However, many individuals now turn to the Internet to tackle unmet information needs and to complement healthcare professional information. The purpose of this study was to qualitatively explore the content of commonly searched cancer websites from a critical nursing perspective, as this information is accessible, and allows patients to address their information needs in ways that healthcare professionals cannot. This qualitative examination of websites is informed by Carper's fundamental patterns of knowing and complemented with the critical view to technology espoused by the philosophy of technology...
January 12, 2018: Nursing Inquiry
https://www.readbyqxmd.com/read/29327010/dna-methylation-assay-using-droplet-based-dna-melting-curve-analysis
#12
F-W Liu, H-F Liao, S-P Lin, Y-W Lu
DNA methylation is an epigenetic regulation of gene expression, which has drawn great attention in biomedical research due to its association with various diseases. A robust, inexpensive platform to detect and quantify the methylation status in a specific genomic region is necessary. In this study, an on-chip analytical technique of cytosine methylation with droplets in a microchannel is proposed. Genomic DNA samples are encapsulated into a series of droplets and transported through a detection region, where a stable temperature gradient is created...
January 12, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29325598/influence-of-peer-review-on-the-reporting-of-primary-outcome-s-and-statistical-analyses-of-randomised-trials
#13
Sally Hopewell, Claudia M Witt, Klaus Linde, Katja Icke, Olubusola Adedire, Shona Kirtley, Douglas G Altman
BACKGROUND: Selective reporting of outcomes in clinical trials is a serious problem. We aimed to investigate the influence of the peer review process within biomedical journals on reporting of primary outcome(s) and statistical analyses within reports of randomised trials. METHODS: Each month, PubMed (May 2014 to April 2015) was searched to identify primary reports of randomised trials published in six high-impact general and 12 high-impact specialty journals. The corresponding author of each trial was invited to complete an online survey asking authors about changes made to their manuscript as part of the peer review process...
January 11, 2018: Trials
https://www.readbyqxmd.com/read/29325533/a-systematic-review-of-comparisons-between-protocols-or-registrations-and-full-reports-in-primary-biomedical-research
#14
Guowei Li, Luciana P F Abbade, Ikunna Nwosu, Yanling Jin, Alvin Leenus, Muhammad Maaz, Mei Wang, Meha Bhatt, Laura Zielinski, Nitika Sanger, Bianca Bantoto, Candice Luo, Ieta Shams, Hamnah Shahid, Yaping Chang, Guangwen Sun, Lawrence Mbuagbaw, Zainab Samaan, Mitchell A H Levine, Jonathan D Adachi, Lehana Thabane
BACKGROUND: Prospective study protocols and registrations can play a significant role in reducing incomplete or selective reporting of primary biomedical research, because they are pre-specified blueprints which are available for the evaluation of, and comparison with, full reports. However, inconsistencies between protocols or registrations and full reports have been frequently documented. In this systematic review, which forms part of our series on the state of reporting of primary biomedical, we aimed to survey the existing evidence of inconsistencies between protocols or registrations (i...
January 11, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29325330/-effects-of-repetitive-transcranial-magnetic-stimulation-on-upper-limb-motor-function-in-patients-with-stroke-a-meta-analysis
#15
H M Ling, T Tao, J Xu, D Xu
Objective: To perform a meta analysis of studies that investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on upper limb motor function in patients with stroke. Methods: We searched for related articles published before October 2015 in MEDLINE(Pubmed) (January 1966 to October 2015), Cochrane Central Register of Controlled Trials (CENTRAL) (October 2015), EMBASE(SCOPUS) (January 1974 to October 2015), Chinese Biomedical Database (CBMDisc) (January 1978 to October 2015), China National Knowledge Infrastructure (CNKI) (January 1979 to October 2015) and Wanfang database(January 1989 to October 2015)...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29324696/quantitative-assessment-of-antimicrobial-activity-of-plga-films-loaded-with-4-hexylresorcinol
#16
Michael Kemme, Regina Heinzel-Wieland
Profound screening and evaluation methods for biocide-releasing polymer films are crucial for predicting applicability and therapeutic outcome of these drug delivery systems. For this purpose, we developed an agar overlay assay embedding biopolymer composite films in a seeded microbial lawn. By combining this approach with model-dependent analysis for agar diffusion, antimicrobial potency of the entrapped drug can be calculated in terms of minimum inhibitory concentrations (MICs). Thus, the topical antiseptic 4-hexylresorcinol (4-HR) was incorporated into poly(lactic-co-glycolic acid) (PLGA) films at different loadings up to 3...
January 11, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29322912/usage-of-cell-nomenclature-in-biomedical-literature
#17
Şenay Kafkas, Sirarat Sarntivijai, Robert Hoehndorf
BACKGROUND: Cell lines and cell types are extensively studied in biomedical research yielding to a significant amount of publications each year. Identifying cell lines and cell types precisely in publications is crucial for science reproducibility and knowledge integration. There are efforts for standardisation of the cell nomenclature based on ontology development to support FAIR principles of the cell knowledge. However, it is important to analyse the usage of cell nomenclature in publications at a large scale for understanding the level of uptake of cell nomenclature in literature by scientists...
December 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29321535/multi-label-deep-learning-for-gene-function-annotation-in-cancer-pathways
#18
Renchu Guan, Xu Wang, Mary Qu Yang, Yu Zhang, Fengfeng Zhou, Chen Yang, Yanchun Liang
The war on cancer is progressing globally but slowly as researchers around the world continue to seek and discover more innovative and effective ways of curing this catastrophic disease. Organizing biological information, representing it, and making it accessible, or biocuration, is an important aspect of biomedical research and discovery. However, because maintaining sophisticated biocuration is highly resource dependent, it continues to lag behind the continually being generated biomedical data. Another critical aspect of cancer research, pathway analysis, has proven to be an efficient method for gaining insight into the underlying biology associated with cancer...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320725/keratin-based-bioplastic-film-from-chicken-feathers-and-its-characterization
#19
Navina Ramakrishnan, Swati Sharma, Arun Gupta, Basma Yahya Alashwal
Plastics have been one of the highly valued materials and it plays an significant role in human's life such as in food packaging and biomedical applications. Bioplastic materials can gradually work as a substitute for various materials based on fossil oil. The issue like sustainability and environmental challenges which occur due to manufacturing and disposal of synthetic plastics can be conquering by bio-based plastics. Feathers are among the most inexpensive abundant, and renewable protein sources. Feathers disposal to the landfills leads to environmental pollutions and it results into wastage of 90% of protein raw material...
January 7, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29319501/unit-of-analysis-issues-in-laboratory-based-research
#20
Nick R Parsons, M Dawn Teare, Alice J Sitch
Many studies in the biomedical research literature report analyses that fail to recognise important data dependencies from multilevel or complex experimental designs. Statistical inferences resulting from such analyses are unlikely to be valid and are often potentially highly misleading. Failure to recognise this as a problem is often referred to in the statistical literature as a unit of analysis (UoA) issue. Here, by analysing two example datasets in a simulation study, we demonstrate the impact of UoA issues on study efficiency and estimation bias, and highlight where errors in analysis can occur...
January 10, 2018: ELife
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