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Influenza infection

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https://www.readbyqxmd.com/read/28526665/the-sensor-study-protocol-for-a-mixed-methods-study-of-self-management-checks-to-predict-exacerbations-of-pseudomonas-aeruginosa-in-patients-with-long-term-respiratory-conditions
#1
Claire Roberts, Thomas L Jones, Samal Gunatilake, Will Storrar, Scott Elliott, Sharon Glaysher, Ben Green, Steven Rule, Carole Fogg, Ann Dewey, Kevin A Auton, Anoop J Chauhan
BACKGROUND: There are an estimated three million people in the United Kingdom with chronic obstructive pulmonary disease (COPD), and the incidence of bronchiectasis is estimated at around 0.1% but is more common in COPD and severe asthma. Both COPD and bronchiectasis are characterized by exacerbations in which bacteria play a central role. Pseudomonas aeruginosa is isolated from sputum samples from 4% to 15% of adults with COPD and is more likely to be isolated from patients with severe disease...
May 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28524070/tmprss2-and-mspl-facilitate-trypsin-independent-porcine-epidemic-diarrhea-virus-replication-in-vero-cells
#2
Wen Shi, Wenlu Fan, Jing Bai, Yandong Tang, Li Wang, Yanping Jiang, Lijie Tang, Min Liu, Wen Cui, Yigang Xu, Yijing Li
Type II transmembrane serine proteases (TTSPs) facilitate the spread and replication of viruses such as influenza and human coronaviruses, although it remains unclear whether TTSPs play a role in the progression of animal coronavirus infections, such as that by porcine epidemic diarrhea virus (PEDV). In this study, TTSPs including TMPRSS2, HAT, DESC1, and MSPL were tested for their ability to facilitate PEDV replication in Vero cells. Our results showed that TMPRSS2 and MSPL played significant roles in the stages of cell-cell fusion and virus-cell fusion, whereas HAT and DESC1 exhibited weaker effects...
May 18, 2017: Viruses
https://www.readbyqxmd.com/read/28524040/-a-case-of-the-severe-human-infection-by-avian-influenza-h7n9-was-rescued-successfully-by-the-sepsis-bundle
#3
Shaohong Wang, Jintao Liu, Haili Luo, Xianguo Pan, Tongmei Yuan, Xuemei Long
One confirmed diagnosis case of severe human infection by avian influenza H7N9 admitted to intensive care unit (ICU) of the Second Affiliated Hospital of Guizhou Medical University on January 12th, 2017 was reported. The patient was treated with the sepsis bundle, and recovered finally, including a series of comprehensive treatments, such as respiratory support, circulation support, antiviral, anti-inflammation, immunization enhancement, critical nursing, fluid management, nutritional support and treatment of complications...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28523924/comparison-of-transcriptional-profiles-of-interferons-cxcl10-and-rig-1-in-influenza-infected-a549-cells-stimulated-with-exogenous-interferons
#4
V Lachová, L Škorvanová, D Svetlíková, L Turianová, A Kostrábová, T Betáková
Type I and type III interferons (IFNs) are induced by viral infection. It was concluded that these IFN species are identical in regulation and biological functions. However, these two systems differ in the tissue expression of their receptors and their transcriptional regulation is fundamentally different as well as cellular signaling pathways that drive expression of each IFN. Here, we have investigated the transcriptional profile of endogenous IFNs after stimulation of cells with exogenous IFNs and subsequent infection of A549 cells with A/chicken/Germany/27 [H7N7] influenza virus...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28523412/epidemiological-risk-factors-for-animal-influenza-a-viruses-overcoming-species-barriers
#5
REVIEW
Kate A Harris, Gudrun S Freidl, Olga S Munoz, Sophie von Dobschuetz, Marco De Nardi, Barbara Wieland, Marion P G Koopmans, Katharina D C Stärk, Kristien van Reeth, Gwen Dauphin, Adam Meijer, Erwin de Bruin, Ilaria Capua, Andy A Hill, Rowena Kosmider, Jill Banks, Kim Stevens, Sylvie van der Werf, Vincent Enouf, Karen van der Meulen, Ian H Brown, Dennis J Alexander, Andrew C Breed
Drivers and risk factors for Influenza A virus transmission across species barriers are poorly understood, despite the ever present threat to human and animal health potentially on a pandemic scale. Here we review the published evidence for epidemiological risk factors associated with influenza viruses transmitting between animal species and from animals to humans. A total of 39 papers were found with evidence of epidemiological risk factors for influenza virus transmission from animals to humans; 18 of which had some statistical measure associated with the transmission of a virus...
May 18, 2017: EcoHealth
https://www.readbyqxmd.com/read/28522352/immune-plasma-for-the-treatment-of-severe-influenza-an-open-label-multicentre-phase-2-randomised-study
#6
John H Beigel, Pablo Tebas, Marie-Carmelle Elie-Turenne, Ednan Bajwa, Todd E Bell, Charles B Cairns, Shmuel Shoham, Jaime G Deville, Eric Feucht, Judith Feinberg, Thomas Luke, Kanakatte Raviprakash, Janine Danko, Dorothy O'Neil, Julia A Metcalf, Karen King, Timothy H Burgess, Evgenia Aga, H Clifford Lane, Michael D Hughes, Richard T Davey
BACKGROUND: Influenza causes substantial morbidity and mortality despite available treatments. Anecdotal reports suggest that plasma with high antibody titres to influenza might be of benefit in the treatment of severe influenza. METHODS: In this randomised, open-label, multicentre, phase 2 trial, 29 academic medical centres in the USA assessed the safety and efficacy of anti-influenza plasma with haemagglutination inhibition antibody titres of 1:80 or more to the infecting strain...
May 15, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28522338/year-round-influenza-immunisation-during-pregnancy-in-nepal-a-phase-4-randomised-placebo-controlled-trial
#7
Mark C Steinhoff, Joanne Katz, Janet A Englund, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Laveta Stewart, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, Monica McNeal, Adriana M Reedy, James M Tielsch
BACKGROUND: Influenza immunisation during pregnancy is recommended but not widely implemented in some low-income regions. We assessed the safety and efficacy in mothers and infants of year-round maternal influenza immunisation in Nepal, where influenza viruses circulate throughout the year. METHODS: In this phase 4, randomised, placebo-controlled trial, we enrolled two consecutive sequential annual cohorts of pregnant women from the Sarlahi district in southern Nepal...
May 15, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28522337/maternal-influenza-immunisation-to-reduce-influenza-infections-and-low-birthweight-in-infants-in-resource-limited-countries
#8
Paul Loubet, Odile Launay
No abstract text is available yet for this article.
May 15, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28522102/retrospective-multicenter-matched-case-control-study-on-the-risk-factors-for-narcolepsy-with-special-focus-on-vaccinations-including-pandemic-influenza-vaccination-and-infections-in-germany
#9
Doris Oberle, Jutta Pavel, Geert Mayer, Peter Geisler, Brigitte Keller-Stanislawski
OBJECTIVE: Studies associate pandemic influenza vaccination with narcolepsy. In Germany, a retrospective, multicenter, matched case-control study was performed to identify risk factors for narcolepsy, particularly regarding vaccinations (seasonal and pandemic influenza vaccination) and infections (seasonal and pandemic influenza) and to quantify the detected risks. METHODS: Patients with excessive daytime sleepiness who had been referred to a sleep center between April 2009 and December 2012 for multiple sleep latency test (MSLT) were eligible...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28521760/avian-influenza-a-h7n9-risk-perception-information-trust-and-adoption-of-protective-behaviours-among-poultry-farmers-in-jiangsu-province-china
#10
Bin Cui, Qiuyan Liao, Wendy Wing Tak Lam, Zong Ping Liu, Richard Fielding
BACKGROUND: Poultry farmers are at high-risk from avian influenza A/H7N9 infection due to sustained occupational exposures to live poultry. This study examined factors associated with poultry farmers' adoption of personal protective behaviours (PPBs) based on Protection Motivation Theory (PMT). METHODS: Totally, 297 poultry farmers in three cities of Jiangsu Province, China were interviewed during November 2013-January 2014. Data on PMT constructs, perceived trustworthiness of A/H7N9 information from mass media (formal sources), friends and family (informal sources), intention to adopt and actual adoption of PPBs and respondents' demographics were collected...
May 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28521605/chemoenzymatic-synthesis-and-characterization-of-n-glycolylneuraminic-acid-carrying-sialoglycopolypeptides-as-effective-inhibitors-against-equine-influenza-virus-hemagglutination
#11
Makoto Ogata, Ami Koizumi, Tadamune Otsubo, Kiyoshi Ikeda, Mao Sakamoto, Rena Aita, Tatsuya Kato, Enoch Y Park, Takashi Yamanaka, Kazuya I P J Hidari
A series of novel sialoglycopolypeptides carrying N-glycolylneuraminic acid (Neu5Gc)-containing trisaccharides having α(2 → 3)- and α(2 → 6)-linkages in the side chains of γ-polyglutamic acid (γ-PGA) were designed as competitive inhibitors against equine influenza viruses (EIV), which critically recognize the Neu5Gc residue for receptor binding. Using horse red blood cells (HRBC) we successfully evaluated the binding activity of the multivalent Neu5Gc ligands to both equine and canine influenza viruses in the hemagglutination inhibition (HI) assay...
May 18, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28520858/rapid-tests-for-influenza-respiratory-syncytial-virus-and-other-respiratory-viruses-a-systematic-review-and-meta-analysis
#12
Ahl Bruning, Mmg Leeflang, Jmbw Vos, R Spijker, M D de Jong, K C Wolthers, D Pajkrt
Rapid diagnosis of respiratory virus infections contributes to patient care. This systematic review evaluates the diagnostic accuracy of rapid tests for the detection of respiratory viruses. We searched Medline and EMBASE for studies evaluating these tests against PCR as reference standard. 179 studies were included of which 134 evaluated rapid tests for influenza viruses, 32 for RSV, and 13 for other respiratory viruses. We used the bivariate random effects model for quantitative meta-analysis of the results...
May 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28518040/highly-pathogenic-avian-influenza-virus-h5n8-clade-2-3-4-4-infection-in-migratory-birds-egypt
#13
Abdullah A Selim, Ahmed M Erfan, Naglaa Hagag, Ali Zanaty, Abdel-Hafez Samir, Mohamed Samy, Ahmed Abdelhalim, Abdel-Satar A Arafa, Mohamed A Soliman, Momtaz Shaheen, Essam M Ibraheem, Ibrahim Mahrous, Mohamed K Hassan, Mahmoud M Naguib
We isolated highly pathogenic avian influenza virus (H5N8) of clade 2.3.4.4 from the common coot (Fulica atra) in Egypt, documenting its introduction into Africa through migratory birds. This virus has a close genetic relationship with subtype H5N8 viruses circulating in Europe. Enhanced surveillance to detect newly emerging viruses is warranted.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28516200/respiratory-viral-infections-are-underdiagnosed-in-patients-with-suspected-sepsis
#14
L R Ljungström, G Jacobsson, B E B Claesson, R Andersson, H Enroth
The study aim was to investigate the prevalence and clinical relevance of viral findings by multiplex PCR from the nasopharynx of clinically septic patients during a winter season. During 11 weeks of the influenza epidemic period in January-March 2012, consecutive adult patients suspected to be septic (n = 432) were analyzed with cultures from blood and nasopharynx plus multiplex PCR for respiratory viruses on the nasopharyngeal specimen. The results were compared with those from microbiology analyses ordered as part of standard care...
May 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28515356/licensing-delineates-helper-and-effector-nk-cell-subsets-during-viral-infection
#15
Anthony E Zamora, Ethan G Aguilar, Can M Sungur, Lam T Khuat, Cordelia Dunai, G Raymond Lochhead, Juan Du, Claire Pomeroy, Bruce R Blazar, Dan L Longo, Jeffrey M Venstrom, Nicole Baumgarth, William J Murphy
Natural killer (NK) cells can be divided into phenotypic subsets based on expression of receptors that bind self-MHC-I molecules, a concept termed licensing or education. Here we show NK cell subsets with different migratory, effector, and immunoregulatory functions in dendritic cell and antigen (ag)-specific CD8+ T cell responses during influenza and murine cytomegalovirus infections. Shortly after infection, unlicensed NK cells localized in draining lymph nodes and produced GM-CSF, which correlated with the expansion and activation of dendritic cells, and resulted in greater and sustained ag-specific T cell responses...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28515301/the-influenza-a-virus-ns1-protein-promotes-efficient-nuclear-export-of-unspliced-viral-m1-mrna
#16
Carina F Pereira, Eliot K C Read, Helen M Wise, Maria J Amorim, Paul Digard
Influenza A virus mRNAs are transcribed by the viral RNA-dependent RNA polymerase in the cell nucleus before being exported to the cytoplasm for translation. Segment 7 produces two major transcripts: an unspliced mRNA that encodes the M1 matrix protein and a spliced transcript that encodes the M2 ion channel. Export of both mRNAs is dependent on the cellular NXF1/TAP pathway but it is unclear how they are recruited to the export machinery or how the intron-containing but unspliced M1 mRNA bypasses the normal quality control checkpoints...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28515300/a-novel-a-h7n2-influenza-virus-isolated-from-a-veterinarian-caring-for-cats-in-a-new-york-city-animal-shelter-causes-mild-disease-and-transmits-poorly-in-the-ferret-model
#17
Jessica A Belser, Joanna A Pulit-Penaloza, Xiangjie Sun, Nicole Brock, Claudia Pappas, Hannah M Creager, Hui Zeng, Terrence M Tumpey, Taronna R Maines
In December 2016, a low pathogenic avian influenza (LPAI) A(H7N2) virus was identified as the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters in New York and Pennsylvania. One person with occupational exposure to infected cats became infected with the virus, representing the first LPAI H7N2 human infection in North America since 2003. Considering the close contact that frequently occurs between companion animals and humans, it was critical to assess the relative risk of this novel virus to public health...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28514976/working-despite-having-influenza-like-illness-results-of-an-anonymous-survey-of-healthcare-providers-who-care-for-transplant-recipients
#18
Sherif B Mossad, Abhishek Deshpande, Sarah Schramm, Xiaobo Liu, Michael B Rothberg
OBJECTIVE To compare the rates of and reasons for presenteeism associated with influenza-like illness (ILI) among healthcare professionals (HCPs) caring for hospitalized inpatient transplant recipients and internal medicine patients. DESIGN We designed a 10-question anonymous survey in which ILI was defined as fever (>37.8°C) and cough and/or sore throat and ILI B was defined as fever (>37.8°C) or cough or sore throat; both definitions were considered in the absence of another known cause. SETTING Tertiary-care center...
May 18, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28514782/a-systematic-review-and-meta-analysis-of-influenza-a-virus-infection-during-pregnancy-associated-with-an-increased-risk-for-stillbirth-and-low-birth-weight
#19
Jing He, Zhi-Wei Liu, Yong-Ping Lu, Tao-Yuan Li, Xu-Jing Liang, Petra C Arck, Si-Min Huang, Berthold Hocher, You-Peng Chen
BACKGROUND/AIMS: Impaired pregnancy outcomes, such as low birth weight are associated with increased disease risk in later life, however little is known about the impact of common infectious diseases during pregnancy on birth weight. The study had two aims: a) to investigate risk factors of influenza virus infection during pregnancy, and b) to analyze the impact of influenza virus infection on pregnancy outcome, especially birth weight. METHODS: Prospective and retrospective observational studies found in PubMed, MEDLINE, Embase, Google Scholar, and WangFang database were included in this meta analysis...
May 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28514692/interferon-%C3%AE-mediates-non-redundant-front-line-antiviral-protection-against-influenza-virus-infection-without-compromising-host-fitness
#20
Ioanna E Galani, Vasiliki Triantafyllia, Evridiki-Evangelia Eleminiadou, Ourania Koltsida, Athanasios Stavropoulos, Maria Manioudaki, Dimitris Thanos, Sean E Doyle, Sergei V Kotenko, Kalliopi Thanopoulou, Evangelos Andreakos
Lambda interferons (IFNλs) or type III IFNs share homology, expression patterns, signaling cascades, and antiviral functions with type I IFNs. This has complicated the unwinding of their unique non-redundant roles. Through the systematic study of influenza virus infection in mice, we herein show that IFNλs are the first IFNs produced that act at the epithelial barrier to suppress initial viral spread without activating inflammation. If infection progresses, type I IFNs come into play to enhance viral resistance and induce pro-inflammatory responses essential for confronting infection but causing immunopathology...
May 16, 2017: Immunity
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