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Marcos Nieves Sedano, José Manuel Caro Teller, Carmen García Muñoz, Delia Fernandez Redondo, Santiago Ponce Aix, Miguel Menéndez Orenga, José Miguel Ferrari Piquero
PURPOSE: Erlotinib and gefitinib are both tyrosine kinase inhibitors (TKIs) approved for the treatment of non-small cell lung cancer (NSCLC). Although it is well known that the increase of gastric pH may decrease the solubility of TKIs, there is limited evidence about the clinical repercussion of this fact. The purpose of this study was to determine if the use of gastric acid suppressive therapy (As) concomitantly with TKIs has an adverse impact on progression-free survival (PFS) and to determine whether the type of drug used (proton pump inhibitors/PPIs or histamine-2 receptors antagonists (H2RAs) may influence it...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Vivian C Nanagas, Anna Kovalszki
Hypereosinophilic syndrome and mastocytosis are relatively rare proliferative diseases encountered in the general population. However, allergists frequently consider these disorders in the differential of patients presenting with gastrointestinal, pulmonary, cutaneous, and allergic symptoms. Gastrointestinal symptoms are some of the most frequent and/or debilitating aspects of both disease states and in many cases lead to poor quality of life and functional limitation for the patient. They are the third most common clinical manifestation in hypereosinophilic syndrome and have been found to be the most distressful aspect of the disorder in those with systemic mastocytosis...
July 12, 2018: Clinical Reviews in Allergy & Immunology
Jung-Ho Noh, Ji-Seong Jeong, Sang-Jin Park, Eun-Young Yun, Jae Sam Hwang, Ji-Young Kim, Kyung-Jin Jung, Hee Jin Park, Hwa-Young Son, Kyoung-Sik Moon
White-spotted flower chafer ( Protaetia brevitarsis ) is an edible insect and its larva was used as a traditional Asian medicine. It's a promising material as a novel food source because of its nutritional components. In this study, as part of the preclinical toxicity program, we evaluated the toxicity of freeze-dried P. brevitarsis larva powder to develop a novel food material. In a single-dose oral toxicity study in rats, there were no changes in mortality, clinical observations, and body weight in rats administered 5000 mg/kg P...
2018: Toxicology Reports
Arunagiri Kamala, Sushil Kumar Middha, Chandrakant S Karigar
The nutgrass, Cyperus rotundus L. (Family: Cyperaceae), is a colonial, perennial herb considered to have originated in India 2000 years ago and widely used in Ayurveda to treat several ailments. In addition to its prehistoric uses, it is used in several systems of medicine for treating variety of diseases. The synergistic actions of the Cyperus ' compounds have added advantage over that of a single constituent. In the past decade, numerous studies proved analgesic, anti-allergic, anti-arthritic, anti-candida, anti-cariogenic, anti-convulsant, anti-diarrheal, anti-emetic, anti-helminthic, anti-histamine, anti-hyperglycemic, anti-hypertensive, anti-inflammatory, anti-malarial, anti-obesity, antioxidant, anti-platelet, anti-pyretic, anti-ulcer, anti-viral, cardioprotective, cytoprotective, cytotoxic, gastroprotective, hepatoprotective, neuroprotective, ovicidal, and larvicidal, wound healing and inhibition of brain Na+ K+ ATPase activities of C...
July 2018: 3 Biotech
Vladimir Zugic, Natasa Mujovic, Sanja Hromis, Jelena Jankovic, Mirjana Drvenica, Aleksandra Perovic, Ivan Kopitovic, Aleksandra Ilic, Dejan Nikolic
BACKGROUND: The aim of this study was to establish whether non-atopic patients with cough variant asthma (CVA) have different pattern of response to direct bronchoconstrictors than non-atopic patients with classic asthma (CA). METHOD: A total of 170 patients of both sexes with stable CVA and CA were screened for the study and 153 were included. Patients with proven atopy were not included and 17 patients with worsening of their condition or with verified bronchial obstruction during screening were excluded...
July 12, 2018: Journal of Clinical Medicine
Takeo Yoshikawa, Tadaho Nakamura, Kazuhiko Yanai
Histamine acts as a neurotransmitter to regulate various physiological functions in CNS. Recent reports showed the involvement of histaminergic dysfunction in neurological disorders. Neurotransmitter clearance is essential to determine brain neurotransmitter concentration. However, molecular mechanism of brain histamine clearance remains largely unknown. First, we examined the molecular mechanism of histamine clearance in primary human astrocytes. We demonstrated that extracellular histamine was transported through organic cation transporter (OCT) 3 and plasma membrane monoamine transporter (PMAT), and subsequently intracellular histamine was inactivated by histamine N-methyltransferase (HNMT) in cytosol...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Yuichi Hattori
Sepsis is the leading cause of death in critically ill patients, and its incidence continues to rise. Sepsis is now defined as life-threatening organ dysfunction due to a dysregulated host response to infection. Histamine assumes a critical role as a major mediator of many pathologic disorders with inflammation and immune reactions. However, direct evidence has not been provided showing the involvement of histamine in the development of multiple organ dysfunction or failure in sepsis. We have found that sepsis-induced major end-organ (lung, liver, and kidney) injury is attenuated in histidine decarboxylase (HDC) gene knockout mice...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Masahiro Ohgami, Takayuki Kaburagi, Atsuhiko Kurosawa, Kosuke Doki, Toshihiro Shiozawa, Nobuyuki Hizawa, Masato Homma
BACKGROUND: Erlotinib is used for treating non-small cell lung cancer (NSCLC). Intestinal absorption of erlotinib is impaired under gastric pH elevation, therefore, co-administration of gastric acid suppressants may provide lower blood concentration of erlotinib. We investigated the effects of erlotinib co-administration with proton pump inhibitors (PPI) and histamine H2 receptor blockers (H2RB) on the plasma concentration of erlotinib and erlotinib-induced adverse reaction in NSCLC patients...
July 9, 2018: Therapeutic Drug Monitoring
Lau F Larsen, Nanna Juel-Berg, Anker Hansen, Kirsten S Hansen, E N Clare Mills, Ronald van Ree, Madeleine Rådinger, Lars K Poulsen, Bettina M Jensen
INTRODUCTION: Mast cells are the primary effector cells of allergy. This study aimed at characterizing human peripheral blood-derived mast cells (PBdMC) from peanut allergic and non-allergic subjects by investigating whether the molecular and stimulus-response profile of PBdMC discriminate between peanut allergic and healthy individuals. METHODS: PBdMC were generated from eight peanut allergic and 10 non-allergic subjects. The molecular profile (cell surface receptor expression) was assessed using flow cytometry...
July 10, 2018: Immunity, Inflammation and Disease
Jian Li, Bin Wang, Yingying Luo, Yajie Bian, Ruipei Wang
Background: Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of pterygoid canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Methods: Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of pterygoid canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA...
2018: Allergy, Asthma, and Clinical Immunology
Dahlia R Weiss, Joel Karpiak, Xi-Ping Huang, Maria Flori Sassano, Jiankun Lyu, Bryan L Roth, Brian K Shoichet
To investigate large library docking's ability to find molecules with joint activity against on-targets, and selectivity versus anti-targets, the dopamine D2 and serotonin 5-HT2A receptors were targeted, seeking selectivity against the histamine H1 receptor. In a second campaign, -opioid receptor ligands were sought with selectivity versus the -opioid receptor. While hit rates ranged from 40% to 63% against the on-targets, they were just as good against the anti-targets, even though the molecules were selected for their putative lack of binding to the off-targets...
July 10, 2018: Journal of Medicinal Chemistry
Carl-Fredrik Johnzon, Josef Dahlberg, Ann-Marie Gustafson, Ida Waern, Ali A Moazzami, Karin Östensson, Gunnar Pejler
Mastitis is an inflammatory condition of the mammary tissue and represents a major problem for the dairy industry worldwide. The present study was undertaken to study how experimentally induced acute bovine mastitis affects inflammatory parameters and changes in the metabolome. To this end, we induced experimental mastitis in nine cows by intramammary infusion of 100 µg purified Escherichia coli lipopolysaccharide (LPS) followed by kinetic assessments of cytokine responses (by enzyme-linked immunosorbent assay), changes in the metabolome (assessed by nuclear magnetic resonance), clinical parameters (heat, local pain perception, redness, swelling, rectal temperature, clot formation, and color changes in the milk), and milk somatic cell counts, at several time points post LPS infusion...
2018: Frontiers in Immunology
Cheng-Chiu Huang, Weishan Yang, Changxiong Guo, Haowu Jiang, Fengxian Li, Maolei Xiao, Steve Davidson, Guang Yu, Bo Duan, Tianwen Huang, Andrew J W Huang, Qin Liu
Itch and pain are refractory symptoms of many ocular conditions. Ocular itch is generated mainly in the conjunctiva and is absent from the cornea. In contrast, most ocular pain arises from the cornea. However, the underlying mechanisms remain unknown. Using genetic axonal tracing approaches, we discover distinct sensory innervation patterns between the conjunctiva and cornea. Further genetic and functional analyses in rodent models show that a subset of conjunctival-selective sensory fibers marked by MrgprA3 expression, rather than corneal sensory fibers, mediates ocular itch...
July 9, 2018: Nature Medicine
Helena A Sterle, Melisa B Nicoud, Noelia A Massari, Mónica A Táquez Delgado, María V Herrero Ducloux, Graciela A Cremaschi, Vanina A Medina
BACKGROUND: Although the role of histamine H4 receptor (H4R) in immune cells is being extensively investigated, its immunomodulatory function in cancer is completely unknown. This study aimed to investigate the role of H4R in antitumour immunity in a model of triple-negative breast cancer. METHODS: We evaluated growth parameters, histological characteristics and the composition of tumour, splenic and tumour draining lymph node (TDLN) immune subsets, in a syngeneic model, developed orthotopically with 4T1 cells in H4R knockout (H4R-KO) and wild-type mice...
July 10, 2018: British Journal of Cancer
Jiali Chen, Bing Yu, Daiwen Chen, Zhiqing Huang, Xiangbing Mao, Ping Zheng, Jie Yu, Junqiu Luo, Jun He
Intestinal barrier plays key roles in maintaining intestinal homeostasis. Inflammation and oxidative damage can severely destroy the intestinal integrity of mammals. Chlorogenic acid (CGA) is a natural polyphenol present in human diet and plants, possessing potent antioxidant and anti-inflammatory activities. This study was conducted to investigate the protective effects of CGA and its molecular mechanisms on intestinal barrier function in a porcine model. Twenty-four weaned pigs were allotted to two groups and fed with a basal diet or a basal diet containing 1000 mg/kg CGA...
June 15, 2018: Journal of Nutritional Biochemistry
K Bjornsdottir-Butler, A Abraham, A Harper, P V Dunlap, R A Benner
Photobacterium species are members of the bacterial communities typically associated with scombrotoxin-forming fish. Reclassification and discovery of new Photobacterium species has caused confusion as to which species are capable of biogenic amine production. We analyzed histamine, cadaverine, and putrescine production by 104 Photobacterium strains representing 23 species. The presence of the genes for histidine decarboxylase ( hdc), lysine decarboxylase ( ldc), and ornithine decarboxylase ( odc) was determined by real-time or conventional PCR and whole genome sequencing...
July 9, 2018: Journal of Food Protection
Arsim Haliti, Lirim Mustafa, Sadi Bexheti, Drita Islami, Adnan Bozalija, Ragip Shabani, Hilmi Islami
AIM: Here we studied the role of meconium in the respiratory system on live and exited newborns (weight 250-3000 g). Throughout this study is followed the response of tracheal rings in acetylcholine and histamine in different molar concentrations (10-1 , 10-2 , 10-3 , 10-4 mol/dm3 ). METHODS: To study the smooth tracheal musculature we used 23 tracheal preparations obtained from the newborns exited from meconium aspiration. RESULTS: Based on the functional analysis of the tracheal specimen we have concluded that the meconium aspiration did not change the smooth musculature response on acetylcholine and histamine when compared to control group, exited from lung inflammatory processes (e...
June 20, 2018: Open Access Macedonian Journal of Medical Sciences
You Yang, Manli Gu
BACKGROUND: To investigate the association between histamine skin reactivity and body mass index (BMI) and other clinical factors, 526 children (3-6 years old) who underwent a skin-prick test (SPT) to diagnose allergic rhinitis were enrolled. METHODS: The SPT was carried out using 43 common allergens (commercial kit). The wheal size was analyzed. The associations between histamine reactivity and age, gender, BMI, atopy, parental smoking history, and testing season were examined...
May 31, 2018: Pediatrics and Neonatology
Adam Schafer, Han Cheng, Rui Xiong, Veronica Soloveva, Cary Retterer, Feiyan Mo, Sina Bavari, Gregory Thatcher, Lijun Rong
Ebola and Marburg are filoviruses and biosafety level 4 pathogens responsible for causing severe hemorrhagic fevers in humans with mortality rates up to 90%. The most recent outbreak in West Africa resulted in approximately 11,310 deaths in 28,616 reported cases. Currently there are no FDA-approved vaccines or therapeutics to treat infections of these deadly viruses. Recently we screened an FDA-approved drug library and identified numerous G protein-coupled receptor (GPCR) antagonists including antihistamines possessing anti-filovirus properties...
July 4, 2018: Antiviral Research
Richard D Rainbow, Sean Brennan, Robert Jackson, Alison J Beech, Amal Bengreed, Helen V Waldschmidt, John Jg Tesmer, Ra John Challiss, Jonathon M Willets
Vasoconstrictor-driven G protein-coupled receptor (GPCR)/phospholipase C (PLC) signalling increases intracellular Ca2+ concentration to mediate arterial contraction. To counteract vasoconstrictor-induced contraction, GPCR/PLC signalling can be desensitized by G protein-coupled receptor kinases (GRKs), with GRK2 playing a predominant role in isolated arterial smooth muscle cells. Here, we utilize an array of GRK2 inhibitors to assess their effects on the desensitization of UTP and angiotensin II-mediated arterial contractions...
July 6, 2018: Molecular Pharmacology
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