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https://www.readbyqxmd.com/read/29342106/adrenergic-agonists-bind-to-adrenergic-receptor-like-regions-of-the-mu-opioid-receptor-enhancing-morphine-and-methionine-enkephalin-binding-a-new-approach-to-biased-opioids
#1
Robert Root-Bernstein, Miah Turke, Udaya K Tiruttani Subhramanyam, Beth Churchill, Joerg Labahn
Extensive evidence demonstrates functional interactions between the adrenergic and opioid systems in a diversity of tissues and organs. While some effects are due to receptor and second messenger cross-talk, recent research has revealed an extracellular, allosteric opioid binding site on adrenergic receptors that enhances adrenergic activity and its duration. The present research addresses whether opioid receptors may have an equivalent extracellular, allosteric adrenergic binding site that has similar enhancing effects on opioid binding...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29339659/fc%C3%AE-r-ros-ck2%C3%AE-is-the-key-inducer-of-nf-%C3%AE%C2%BAb-activation-in-a-murine-model-of-asthma
#2
June-Mo Kim, Hae-Kyoung Kim, Yoo-Na Im, Yun-Soo Bae, Suhn-Young Im, Hern-Ku Lee
BACKGROUND: The transcription factor nuclear factor (NF)-κB plays a pivotal role in the development of allergic airway inflammation. However, the mechanism of NF-κB activation in asthma remains to be elucidated. METHODS: CK2α activation was assessed by CK2α phosphorylation and protein expression. Airway levels of histamine and cytokines were determined by ELISA. We used 2 (active and passive) forms of allergic pulmonary inflammation models. In the active form, the animals were immunized with ovalbumin (OVA) intraperitoneally, followed by an airway challenge with OVA...
January 17, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29339438/quantifying-exosome-secretion-from-single-cells-reveals-a-modulatory-role-for-gpcr-signaling
#3
Frederik Johannes Verweij, Maarten P Bebelman, Connie R Jimenez, Juan J Garcia-Vallejo, Hans Janssen, Jacques Neefjes, Jaco C Knol, Richard de Goeij-de Haas, Sander R Piersma, S Rubina Baglio, Matthijs Verhage, Jaap M Middeldorp, Anoek Zomer, Jacco van Rheenen, Marc G Coppolino, Ilse Hurbain, Graça Raposo, Martine J Smit, Ruud F G Toonen, Guillaume van Niel, D Michiel Pegtel
Exosomes are small endosome-derived extracellular vesicles implicated in cell-cell communication and are secreted by living cells when multivesicular bodies (MVBs) fuse with the plasma membrane (PM). Current techniques to study exosome physiology are based on isolation procedures after secretion, precluding direct and dynamic insight into the mechanics of exosome biogenesis and the regulation of their release. In this study, we propose real-time visualization of MVB-PM fusion to overcome these limitations. We designed tetraspanin-based pH-sensitive optical reporters that detect MVB-PM fusion using live total internal reflection fluorescence and dynamic correlative light-electron microscopy...
January 16, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29337364/the-function-of-emulsions-on-the-biogenic-amine-formation-and-their-indices-of-sea-bass-fillets-dicentrarchus-labrax-stored-in-vacuum-packaging
#4
Yesim Ozogul, Mustafa Durmus, Esmeray Kuley Boga, Yılmaz Uçar, Fatih Ozogul
The impacts of emulsions based on commercial oils on the biogenic amine formation and their indices of vacuumed packed sea bass fillets were investigated. The results showed that among biogenic amines, cadaverine, putrescine, spermidine, spermine, serotonin, dopamine, and agmatine were predominant amines in sea bass fillets stored under vacuum packaging. Significant differences (P < 0.05) in biogenic amines concentrations of vacuumed packed sea bass treated with emulsions were observed. All groups contained histamine lower than 5...
January 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29336714/urinary-retention-and-medication-utilization-on-a-palliative-care-unit-a-retrospective-observational-study
#5
T Graham Bergstra, Iris Gutmanis, Janette Byrne, Cathy Faulds, Patricia Whitfield, Sarah McCallum, Joshua Shadd
Urinary retention is a common problem at end-of-life that may be a result of medications used to control other symptoms. To determine whether use of retention-causing drugs was associated with catheterization for urinary retention among palliative care unit (PCU) patients, the authors reviewed charts of 91 consecutively admitted patients to a hospital-based PCU. Utilization of eight classes of retention-causing medications (opioids, antidopaminergics, benzodiazepines, anticholinergics, antidepressants, calcium channel antagonists, nonsteroidal anti-inflammatory drugs [NSAIDs], and H1 histamine antagonists) was compared between those catheterized for urinary retention (n = 34) and those never catheterized (n = 31)...
January 16, 2018: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/29336285/optimal-cutoff-values-of-allergen-specific-immunoglobulin-e-to-house-dust-mites-and-animal-dander-based-on-skin-prick-test-results-analysis-in-16-209-patients-with-allergic-rhinitis
#6
Sang Duk Hong, Gwanghui Ryu, Min Young Seo, Jong In Jeong, Hyo Yeol Kim, Seung-Kyu Chung, Hun-Jong Dhong
BACKGROUND: The most common tests for allergen sensitization in patients with allergic rhinitis are the skin-prick test (SPT) and an in vitro test to detect serum specific immunoglobulin E (sIgE). However, in vitro allergen test results were interpreted dichotomically as positive or negative at a threshold of 0.35 kU/L of sIgE, regardless of the patient characteristics or antigen types. OBJECTIVE: The purpose of this study was to determine the cutoff value for sIgE in house-dust mites and animal dander, and to analyze differences in cutoff value according to age and gender...
January 25, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29335496/localization-and-function-of-neurosecretory-protein-gm-a-novel-small-secretory-protein-in-the-chicken-hypothalamus
#7
Kenshiro Shikano, Yuki Bessho, Masaki Kato, Eiko Iwakoshi-Ukena, Shusuke Taniuchi, Megumi Furumitsu, Tetsuya Tachibana, George E Bentley, Lance J Kriegsfeld, Kazuyoshi Ukena
Recently, we discovered a novel cDNA encoding the precursor of a small secretory protein, neurosecretory protein GL (NPGL), in the hypothalamic infundibulum of chickens. NPGL plays an important role in the regulation of growth and feeding. A database search indicated that the NPGL gene has a paralogous gene: neurosecretory protein GM (NPGM), also in chickens. We identified cDNA encoding the NPGM precursor in chickens. Morphological analysis showed that NPGM-containing cells are specifically localized in the medial mammillary nucleus (MM) and infundibular nucleus (IN) in the hypothalamus...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334795/progress-in-the-development-of-histamine-h3-receptor-antagonists-inverse-agonists-a-patent-review-2013-2017
#8
Dorota Łażewska, Katarzyna Kieć-Kononowicz
Since years, ligands blocking histamine H3 receptor (H3R) activity (antagonists/inverse agonists) are interesting targets in the search for new cures for CNS disorders. Intensive works done by academic and pharmaceutical company researchers have led to many potent and selective H3R antagonists/inverse agonists. Some of them have reached to clinical trials. Areas covered: Patent applications from January 2013 to September 2017 and the most important topics connected with H3R field are analysed. Espacenet, Patentscope, Pubmed, GoogleScholar or Cochrane Library online databases were principially used to collect all the materials...
January 15, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29328919/color-processing-in-the-early-visual-system-of-drosophila
#9
Christopher Schnaitmann, Väinö Haikala, Eva Abraham, Vitus Oberhauser, Thomas Thestrup, Oliver Griesbeck, Dierk F Reiff
Color vision extracts spectral information by comparing signals from photoreceptors with different visual pigments. Such comparisons are encoded by color-opponent neurons that are excited at one wavelength and inhibited at another. Here, we examine the circuit implementation of color-opponent processing in the Drosophila visual system by combining two-photon calcium imaging with genetic dissection of visual circuits. We report that color-opponent processing of UVshort/blue and UVlong/green is already implemented in R7/R8 inner photoreceptor terminals of "pale" and "yellow" ommatidia, respectively...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29326337/acid-suppressive-drug-use-during-pregnancy-and-the-risk-of-childhood-asthma-a-meta-analysis
#10
REVIEW
Tianwen Lai, Mindan Wu, Juan Liu, Man Luo, Lulu He, Xiaohui Wang, Bin Wu, Songmin Ying, Zhihua Chen, Wen Li, Huahao Shen
CONTEXT: The association between acid-suppressive drug exposure during pregnancy and childhood asthma has not been well established. OBJECTIVE: To conduct a systematic review and meta-analysis on this association to provide further justification for the current studies. DATA SOURCES: We searched PubMed, Medline, Embase, the Cochrane Database of Systematic Reviews, EBSCO Information Services, Web of Science, and Google Scholar from inception until June 2017...
January 11, 2018: Pediatrics
https://www.readbyqxmd.com/read/29320765/emerging-treatment-options-in-atopic-dermatitis-systemic-therapies
#11
Uffe Nygaard, Christian Vestergaard, Mette Deleuran
The pathogenesis of atopic dermatitis (AD) is multifactorial and intricate, and the clinical presentation of the condition varies greatly. Symptoms and severity depend on individual trigger factors and stage of the disease. The majority of AD patients are sufficiently treated with emollients in combination with existing topical or systemic therapies. Yet treatment failure with existing drugs and treatment options can be a significant clinical problem. New treatments are under development, and the majority of these new drugs focus on targeting a skewed immune response in AD...
January 11, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29319332/nebivolol-attenuates-oxidative-stress-and-inflammation-in-a-guinea-pig-model-of-ovalbumin-induced-asthma-a-possible-mechanism-for-its-favorable-respiratory-effects
#12
Sally A Abuelezz
An experimental model of ovalbumin (OVA) induced asthma was used to assess the effects of nebivolol, the third-generation selective β1-adrenergic receptor blocker, on airway reactivity, lung inflammation, and oxidative stress markers. The asthma induction protocol was done by OVA sensitization and challenge. Guinea pigs were classified into control, asthmatic, or asthmatic receiving nebivolol either 7.5 or 15 mg·kg-1·day-1 orally. At the end of the study respiratory, the anti-inflammatory and antioxidative effects of nebivolol were assessed...
January 10, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29316507/the-%C3%AE-carbonic-anhydrase-from-the-pathogenic-bacterium-vibrio-cholerae-is-potently-activated-by-amines-and-amino-acids
#13
Andrea Angeli, Sonia Del Prete, William A Donald, Clemente Capasso, Claudiu T Supuran
The γ-class carbonic anhydrase (CAs, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae, VchCAγ, was investigated for its activation with a panel of natural and non-natural amino acids and amines. The enzyme was effectively activated by l-tryptophan, 1-(2-minoethyl)-piperazine and 4-(2-aminoethyl)-morpholine, in the low nanomolar range (KAs 8-71 nM). In contrast, l-/d-Phe, l-/d-DOPA, d-Trp, l-/d-Tyr, 4-amino-l-Phe, histamine, dopamine, serotonin, some pyridyl-alkylamines, as well as l-adrenaline were submicromolar activators (KAs between 0...
January 4, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29315920/percutaneous-prick-test-irritant-threshold-concentrations-for-eight-allergens-in-healthy-nonsedated-dogs-in-the-usa
#14
Matthew J H Carnett, Jon D Plant
BACKGROUND: Percutaneous testing (PT) is preferred to intradermal testing in humans for the in vivo identification of allergen hypersensitivity, but the methodology has not been well described for use in dogs with atopic dermatitis. HYPOTHESIS/OBJECTIVES: To identify the irritant threshold concentrations (ITC) of eight aeroallergens using a commercial prick test device in normal dogs. ANIMALS: Twenty healthy, privately owned dogs. METHODS: Percutaneous testing was performed using the GREER® Pick® System (Stallergenes Greer; Lenoir, NC, USA)...
January 8, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29315624/prenatal-alcohol-exposure-increases-histamine-h3-receptor-mediated-inhibition-of-glutamatergic-neurotransmission-in-rat-dentate-gyrus
#15
Rafael K Varaschin, Nyika A Allen, Martina J Rosenberg, C Fernando Valenzuela, Daniel D Savage
BACKGROUND: We have reported that prenatal alcohol exposure (PAE)-induced deficits in dentate gyrus, long-term potentiation (LTP), and memory are ameliorated by the histamine H3 receptor inverse agonist ABT-239. Curiously, ABT-239 did not enhance LTP or memory in control offspring. Here, we initiated an investigation of how PAE alters histaminergic neurotransmission in the dentate gyrus and other brain regions employing combined radiohistochemical and electrophysiological approaches in vitro to examine histamine H3 receptor number and function...
December 5, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29315616/in-chronic-spontaneous-urticaria-ige-against-staphylococcal-enterotoxins-is-common-and-functional
#16
S Altrichter, T Hawro, M Liedtke, G Holtappels, C Bachert, P S Skov, M Maurer
BACKGROUND: Chronic spontaneous urticaria (CSU) is a frequent disorder with recurrent itchy wheals and/or angioedema. Despite the known effectiveness of omalizumab therapy, the relevant IgE antigens are largely unknown. Recently, increased rates of elevated levels of IgE towards Staphylococcus aureus enterotoxins (SEs) were described in CSU. AIM: To assess the prevalence and functional relevance of IgE to SEs in CSU. METHOD: We investigated serum levels of IgE against SEs in 49 CSU patients and in 15 CSU patients additional specific IgE to SE components and basophil histamine release (BHR)...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29313079/comprehensive-characterization-of-neurochemicals-in-three-zebrafish-chemical-models-of-human-acute-organophosphorus-poisoning-using-liquid-chromatography-tandem-mass-spectrometry
#17
Cristian Gómez-Canela, Daniel Tornero-Cañadas, Eva Prats, Benjamí Piña, Romà Tauler, Demetrio Raldúa
There is a growing interest in biological models to investigate the effect of neurotransmitter dysregulation on the structure and function of the central nervous system (CNS) at different stages of development. Zebrafish, a vertebrate model increasingly used in neurobiology and neurotoxicology, shares the common neurotransmitter systems with mammals, including glutamate, GABA, glycine, dopamine, norepinephrine, epinephrine, serotonin, acetylcholine, and histamine. In this study, we have evaluated the performance of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the multiresidue determination of neurotransmitters and related metabolites...
January 9, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29310423/phloxine-o-a-cosmetic-colorant-suppresses-the-expression-of-thymic-stromal-lymphopoietin-and-acute-dermatitis-symptoms-in-mice
#18
Hye Eun Lee, Gabsik Yang, Kyu-Bong Kim, Byung-Mu Lee, Joo Young Lee
Cosmetics are primarily applied to the skin; therefore, the association of cosmetic dyes with skin diseases or inflammation is a topic of great interest. Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine that activates dendritic cells to promote Th2 inflammatory immune responses. TSLP is highly expressed in keratinocytes under inflammatory conditions, which suggests that it may play a critical role in the development of skin diseases, such as atopic dermatitis. Therefore, we investigated whether cosmetic dyes influenced the production of TSLP by keratinocytes...
January 9, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29309903/histamine-h4-receptor-antagonism-prevents-the-progression-of-diabetic-nephropathy-in-male-dba2-j-mice
#19
Alessandro Pini, Cristina Grange, Eleonora Veglia, Monica Argenziano, Roberta Cavalli, Daniele Guasti, Laura Calosi, Corrado Ghè, Roberto Solarino, Robin L Thurmond, Giovanni Camussi, Paul L Chazot, Arianna Carolina Rosa
Due to the incidence of diabetes and the related morbidity of diabetic nephropathy, identification of new therapeutic strategies represents a priority. In the last few decades new and growing evidence on the possible role of histamine in diabetes has been provided. In particular, the histamine receptor H4R is emerging as a new promising pharmacological target for diabetic nephropathy. The aim of this study was to evaluate the efficacy of selective H4R antagonism by JNJ39758979 on the prevention of diabetic nephropathy progression in a murine model of diabetes induced by streptozotocin injection...
January 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29309856/role-of-histamine-h1-receptor-in-caffeine-induced-locomotor-sensitization
#20
Shalu Kumar, Lokesh Verma, Nishant S Jain
The present study attempted to elucidate the role histamine H1 receptor in the caffeine induced locomotor sensitization. Intermittent administration of caffeine (15 mg/kg, i.p.) on alternate days (induction phase) i.e. 1st, 3rd, 5th, 7th, 9th, 11th and 13th resulted in the development of locomotor sensitization. In addition, challenge with sub-stimulant dose of caffeine (10 mg/kg, i.p.), directly on 17th day to induction group animals resulted in expression to locomotor sensitization to caffeine. I.c.v...
January 5, 2018: Neuroscience Letters
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