keyword
https://read.qxmd.com/read/38371361/a-cross-sectional-study-on-the-bidirectional-interactions-between-leptospirosis-and-hiv-infection-among-patients-from-maputo-central-hospital-mozambique
#21
JOURNAL ARTICLE
Isac Rodrigues Comia, Leonardo Manuel, Regina Daniel Miambo, Awa Abdul Carimo, Percílio da Floca Manjate, Ana Edith Maholela, Lucas Raimundo Banze, Titos Paulo Buene, Noémia Nhancupe, Irina M Sousa, Constance A Benson, Robert T Schooley, Jahit Sacarlal, Emília Virgínia Noormahomed
INTRODUCTION: This study aims to determine the baseline seroprevalence of leptospirosis, a zoonotic and neglected disease, in people living with HIV (PWH) in Maputo, Mozambique, and to evaluate the relationship between selected HIV-related factors that might influence risk of coinfection with leptospirosis, such as degree of immunosuppression, as assessed by CD4 cell count, World Health Organization (WHO) HIV/AIDS clinical stage and antiretroviral therapy (ART) intake. METHODS: This was a descriptive cross-sectional analysis of 157 PWH, aged over 18 years old, admitted to the Maputo Central Hospital, in Maputo, Mozambique, between March 2020 and October 2021...
2024: Research and Reports in Tropical Medicine
https://read.qxmd.com/read/38371008/leptospirosis-and-dengue-coinfection-associated-multi-organ-dysfunction-syndrome-a-case-report
#22
Govind Shiddapur, Vutukuru Kalyan Kumar Reddy, Mohith Prakash Kondapalli, Saimounika Adapa, Sonali Agarwal
Dengue and leptospirosis are frequently discussed separately, with dengue causing rash and leptospirosis causing jaundice. Currently, there are more and more reports of coinfections. The comparable clinical symptoms of both infections make it challenging to distinguish between leptospirosis and dengue. Differentiating between leptospirosis and dengue is crucial since leptospirosis has a more favorable prognosis with early antibiotic therapy, whereas dengue does not have a specific treatment, although early detection is essential for close monitoring and cautious fluid management...
January 2024: Curēus
https://read.qxmd.com/read/38367538/fatal-leptospirosis-in-endangered-barbary-macaques-macaca-sylvanus-kept-in-captivity-assessing-the-role-of-sympatric-rodents
#23
JOURNAL ARTICLE
Adrián Beato-Benítez, David Cano-Terriza, Moisés Gonzálvez, Remigio Martínez, Iratxe Pérez-Cobo, María José Ruano, Rafael Guerra, Elena Mozos-Mora, Ignacio García-Bocanegra
Between December 2020 and January 2021, an outbreak of acute mortality in endangered Barbary macaques (Macaca sylvanus) kept in captivity was detected in a zoo in Spain. The main findings observed in the two fatally affected animals at post-mortem evaluation were jaundice, renal tubular necrosis and interstitial nephritis. Leptospira spp. infection was confirmed by real time PCR (qPCR) in different tissues in both individuals. Analyses of secY gene from a positive individual showed 100% homology with a previously published sequence corresponding to Leptospira interrogans serovar Copenhageni...
February 14, 2024: Veterinary Microbiology
https://read.qxmd.com/read/38367297/investigation-of-anti-leptospira-spp-antibodies-and-leptospiruria-in-cats-attended-to-a-veterinary-teaching-hospital-in-southern-brazil
#24
JOURNAL ARTICLE
Mirela Grünwalder Paim, Bárbara Basseggio Rivas, Grasiele Amorim Sebastião, Kauana Kaefer, Rogério Oliveira Rodrigues, Fabiana Quoos Mayer, Luciana Neves Nunes, Fernanda Vieira Amorim da Costa
Leptospirosis is a bacterial zoonosis that affects both humans and animals worldwide. Currently, it is known that cats may be susceptible to infection. This study aims to investigate the presence of anti-Leptospira spp. antibodies and leptospiruria in cats, using Microscopic Agglutination Test (MAT) and Real-time Polymerase Chain Reaction (PCR) techniques, respectively. A total of 76 cats, undergoing comprehensive anamnesis, general physical examination, and complementary exams were included in the investigation...
February 3, 2024: Comparative Immunology, Microbiology and Infectious Diseases
https://read.qxmd.com/read/38364905/global-proteome-of-the-saprophytic-strain-leptospira-biflexa-and-comparative-analysis-with-pathogenic-strain-leptospira-interrogans-uncover-new-pathogenesis-mechanisms
#25
JOURNAL ARTICLE
Edson G Nascimento Filho, Mônica L Vieira, Meriellen Dias, Maria A Mendes, Fabio B Sanchez, João C Setubal, Marcos B Heinemann, Gisele O Souza, Daniel C Pimenta, Ana L T O Nascimento
Leptospira is a genus of bacteria that includes free-living saprophytic species found in water or soil, and pathogenic species, which are the etiologic agents of leptospirosis. Besides all the efforts, there are only a few proteins described as virulence factors in the pathogenic strain L. interrogans. This work aims to perform L. biflexa serovar Patoc1 strain Paris global proteome and to compare with the proteome database of pathogenic L. interrogans serovar Copenhageni strain Fiocruz L1-130. We identified a total of 2327 expressed proteins of L...
February 14, 2024: Journal of Proteomics
https://read.qxmd.com/read/38362624/epidemiology-of-reported-cases-of-leptospirosis-in-the-eu-eea-2010-to-2021
#26
JOURNAL ARTICLE
Julien Beauté, Francesco Innocenti, Aristos Aristodimou, Michaela Špačková, Caroline Eves, Natalia Kerbo, Ruska Rimhanen-Finne, Mathieu Picardeau, Mirko Faber, Georgios Dougas, Anna Margrét Halldórsdóttir, Sarah Jackson, Viktorija Leitēna, Anne Vergison, Maria Louise Borg, Roan Pijnacker, Małgorzata Sadkowska-Todys, João Vieira Martins, Lavinia Cipriana Rusu, Eva Grilc, Rosa M Estévez-Reboredo, Taina Niskanen, Therese Westrell
BackgroundLeptospirosis is a zoonotic disease caused by bacteria of the genus Leptospira . Humans are infected by exposure to animal urine or urine-contaminated environments. Although disease incidence is lower in Europe compared with tropical regions, there have been reports of an increase in leptospirosis cases since the 2000s in some European countries.AimWe aimed to describe the epidemiology of reported cases of leptospirosis in the European Union/European Economic Area (EU/EEA) during 2010-2021 and to identify potential changes in epidemiological patterns...
February 2024: Euro Surveillance
https://read.qxmd.com/read/38351504/global-distribution-of-leptospira-serovar-isolations-and-detections-from-animal-host-species-a-systematic-review-and-online-database
#27
REVIEW
Nienke N Hagedoorn, Michael J Maze, Manuela Carugati, Shama Cash-Goldwasser, Kathryn J Allan, Kevin Chen, Brieuc Cossic, Elena Demeter, Sarah Gallagher, Richard German, Renee L Galloway, Josipa Habuš, Matthew P Rubach, Kanae Shiokawa, Nadezhda Sulikhan, John A Crump
OBJECTIVES: Leptospira, the spirochaete causing leptospirosis, can be classified into >250 antigenically distinct serovars. Although knowledge of the animal host species and geographic distribution of Leptospira serovars is critical to understand the human and animal epidemiology of leptospirosis, current data are fragmented. We aimed to systematically review, the literature on animal host species and geographic distribution of Leptospira serovars to examine associations between serovars with animal host species and regions and to identify geographic regions in need of study...
February 13, 2024: Tropical Medicine & International Health
https://read.qxmd.com/read/38350005/acute-unilateral-hypertensive-uveitis-in-leptospirosis-a-case-report
#28
JOURNAL ARTICLE
Yogish Subraya Kamath, Alisha Rizvi, Shashidhar Vishwanath, Ravikumar T N, Raghavendra Rao, Ram Bhat
PURPOSE: We report the rare occurrence of unilateral acute hypertensive uveitis in the acute phase of systemic leptospirosis. METHODS: Observational case report and review of literature. RESULTS: A young male mason from coastal Karnataka in south India, presenting with acute febrile illness, was diagnosed to have systemic leptospirosis. He also had features of sudden raised intraocular pressure with anterior uveitis in one eye, which subsided with medical management...
February 13, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38334229/retrospective-evaluation-of-22-dogs-with-leptospirosis-treated-with-extracorporeal-renal-replacement-therapies-2018-2021
#29
JOURNAL ARTICLE
Antonia Da Fonseca Ioannou, Carolyn Tai, Mary Anna Labato, Emmanuelle M Butty
BACKGROUND: Outcomes of dogs with acute kidney injury secondary to leptospirosis (AKI-L) treated using renal replacement therapies (RRT) are poorly characterized. HYPOTHESIS/OBJECTIVES: Describe survival to discharge, short (≤30 days) and long-term (≥6 months) outcomes of AKI-L dogs receiving RRT and determine if there is a significant difference in maximum blood urea nitrogen (maxBUN), maximum creatinine (maxCr), maximum bilirubin (maxBili) and the number of body systems affected between survivors and non-survivors...
February 9, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38333303/unraveling-the-leptospirosis-epidemic-tales-from-the-philippine-outbreak-a-short-communication
#30
JOURNAL ARTICLE
Abubakar Nazir, Malik Olatunde Oduoye, Awais Nazir, Chukwudile B Uzoamaka, Muhammad Ali Muzammil, Salma Mohsen Sakr, Godfred Y Scott, Mahammed Khan Suheb
Leptospirosis, also known as Weil's disease, is an emerging zoonotic infection that occurs worldwide but is particularly common in the tropics. There has been an increasing trend of leptospirosis in the Philippines since the outbreak occurred in 2020. The number of reported cases was 182 in 2020, 1661 in 2021, and 2794 in 2022. This present article aimed to access previously published studies on the prevalence, implications, and efforts to combat leptospirosis worldwide, with a particular focus on the Philippines from 2001 to 2023...
February 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38328369/pathological-and-molecular-study-of-kidneys-in-apparently-healthy-cattle-and-sheep-with-special-reference-to-leptospira-species-in-central-and-northern-jordan
#31
JOURNAL ARTICLE
Nabil Q Hailat, Zaid A Mafrag, Mohammad H Gharaibeh, Ibrahim M Alzuheir
BACKGROUND AND AIM: Renal pathological conditions can cause significant economic losses for livestock owners. This study investigated and described the gross pathology and histopathology of lesions found in the kidneys of sheep and cattle, with particular attention to the presence of Leptospira spp. MATERIALS AND METHODS: Three hundred and sixty kidneys from apparently healthy sheep and cattle (208 and 152, respectively) were collected from slaughterhouses in Jordan for gross and histopathological examinations, multiplex polymerase chain reaction (PCR) analysis, and gene sequencing of Leptospira spp...
December 2023: Veterinary World
https://read.qxmd.com/read/38326762/diagnosis-of-human-leptospirosis-systematic-review-and-meta-analysis-of-the-diagnostic-accuracy-of-the-leptospira-microscopic-agglutination-test-pcr-targeting-lfb1-and-igm-elisa-to-leptospira-fainei-serovar-hurstbridge
#32
JOURNAL ARTICLE
Marta Valente, Justina Bramugy, Suzanne H Keddie, Heidi Hopkins, Quique Bassat, Oliver Baerenbold, John Bradley, Jane Falconer, Ruth H Keogh, Paul N Newton, Mathieu Picardeau, John A Crump
BACKGROUND: Leptospirosis is an underdiagnosed infectious disease with non-specific clinical presentation that requires laboratory confirmation for diagnosis. The serologic reference standard remains the microscopic agglutination test (MAT) on paired serum samples. However, reported estimates of MAT's sensitivity vary. We evaluated the accuracy of four index tests, MAT on paired samples as well as alternative standards for leptospirosis diagnosis: MAT on single acute-phase samples, polymerase chain reaction (PCR) with the target gene Lfb1, and ELISA IgM with Leptospira fainei serovar Hurstbridge as an antigen...
February 7, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38324815/diffuse-alveolar-hemorrhage-as-a-presentation-of-severe-anicteric-leptospirosis
#33
JOURNAL ARTICLE
Andrés Eduardo Prieto Torres, Sergio Andrés Bolívar-Lozano, Álvaro A Faccini-Martínez
No abstract text is available yet for this article.
2024: Revista da Sociedade Brasileira de Medicina Tropical
https://read.qxmd.com/read/38320623/proteomic-profiles-of-leptospira-borgpetersenii-serovar-hardjo-strains-jb197-and-hb203-cultured-at-different-temperatures
#34
JOURNAL ARTICLE
Ellie J Putz, Luis G V Fernandes, Kaitlyn M Sarlo Davila, Julian Whitelegge, John D Lippolis, Jarlath E Nally
Leptospirosis is a global zoonotic disease affecting humans, domestic, and wild animals. Leptospira are typically shed in the urine of reservoir hosts which persist in suitable environments where incidental hosts transmission occurs after direct contact with infected urine or contaminated environments. Interestingly, serologically identical L. borgpetersenii serovar Hardjo strains JB197 and HB203 show divergent disease severity in the hamster model; JB197 causes severe acute infection while HB203 causes persistent chronic infection...
February 4, 2024: Journal of Proteomics
https://read.qxmd.com/read/38314303/severe-jarisch-herxheimer-reaction-jhr-in-a-leptospirosis-patient-a-case-report
#35
Ruo-Yan Zhao, Meng-Die Liu, Ying-Xin Lin, Lei Huang
Leptospirosis is a zoonosis that is related to potential respiratory, renal, neurological, and cardiovascular failure. At present, antibiotics are the recommended treatment, but due to the underlying cause of the disease, they may induce the Jarisch-Herxheimer reaction (JHR) within 24 hours. At the same time, we speculate that JHR may aggravate the natural course of leptospirosis. Considering that there are few available reports on this event, we will share a case of pulmonary hemorrhagic leptospirosis, where antibiotic treatment is suspected to have triggered the JHR...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38306792/novel-leptospirosis-research-at-lincoln-memorial-university
#36
JOURNAL ARTICLE
Ashutosh Verma, Julie Hunt
No abstract text is available yet for this article.
January 29, 2024: American Journal of Veterinary Research
https://read.qxmd.com/read/38288193/leptospirosis-induced-septic-shock-and-multi-organ-dysfunction-syndrome-a-complex-case-of-zoonotic-infection-in-a-young-female-patient
#37
Nino Gvajaia, Mariam Tkeshelashvili, Levan Ratiani, Elene Pachkoria, Ia Mikadze
Leptospirosis, a zoonotic infection caused by the Leptospira bacteria, can manifest with varying clinical severities, ranging from subclinical disease to severe multiorgan failure. This progression to severe multiorgan failure, also known as multi-organ dysfunction syndrome (MODS), is a life-threatening condition characterized by the dysfunction of two or more organ systems. Often, MODS is a consequence of events triggered by underlying pathologies, such as severe infections, including those caused by Leptospira ...
December 2023: Curēus
https://read.qxmd.com/read/38275782/bovine-genital-leptospirosis-an-update-of-this-important-reproductive-disease
#38
REVIEW
Luiza Aymée, Julia Mendes, Walter Lilenbaum
Bovine leptospirosis is an important disease that affects the reproductive sphere. Due to its high relevance for the bovine production chain in a worldwide scenario, a better understanding of the disease is crucial to reduce its negative impacts. The main agents are strains from the Sejroe serogroup, such as Hardjo and Guaricura, which lead to renal and genital infection. The genital colonization causes a chronic, silent, and subclinical reproductive syndrome, called Bovine Genital Leptospirosis (BGL). Embryonic death, estrus repetition, subfertility, and abortions are the main signs of BGL condition in females...
January 20, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38265373/leptospirosis-associated-digital-gangrene-of-lower-extremities-two-cases-and-review-of-literature
#39
Anju Dinkar, Jitendra Singh, Mahima Yadav
BACKGROUND: Leptospirosis is the most common zoonotic illness worldwide, caused by pathogenic spirochete bacteria called Leptospira. It is clinically presented with mild to moderate in most cases. However, sometimes, the course may be severe with multiorgan dysfunction. CASE PRESENTATION: We present two rare cases of leptospirosis with peripheral dry gangrene of the lower extremities. A 25-year-old male, farmer by occupation without any significant past medical history had been diagnosed with a case of leptospirosis that complicated to digital gangrene on 15 days of illness during hospitalization...
January 22, 2024: Infectious Disorders Drug Targets
https://read.qxmd.com/read/38260656/eco-epidemiological-study-of-seropositivity-against-rickettsia-and-leptospira-agents-in-rural-areas-of-urab%C3%A3-colombia
#40
Mariana Torres-Bustamante, Omar Cantillo-Barraza, Albert I Ko, Elsio A Wunder, Juan C Quintero-Vélez
Rickettsioses and leptospirosis are infectious diseases that are often underdiagnosed due to a lack of knowledge about their epidemiology, pathophysiology, diagnosis, management, among others. Objetive: to characterize the seroprevalence and seroincidence of both Rickettsia and Leptospira agents and determine the risk factors for these outcomes in rural areas of Urabá, Antioquia. Methods: a secondary data analysis using information on Rickettsia and Leptospira exposure from a prior prospective study that explored sociocultural and ecological aspects of Rickettsia infection in rural Urabá, Colombia...
January 4, 2024: Research Square
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