keyword
MENU ▼
Read by QxMD icon Read
search

leptospirosys

keyword
https://www.readbyqxmd.com/read/29777636/vntr-analysis-demonstrates-new-patterns-and-high-genetic-diversity-of-leptospira-sp-of-animal-origin-in-brazil
#1
Lauren Hubert Jaeger, Ana Paula Loureiro, Walter Lilenbaum
Leptospirosis is a worldwide zoonosis with a broad host range, including humans and domestic and wild animals. The taxonomic classification of Leptospira species is complex. More recently several molecular tools have been employed in the attempt to group the different strains of leptospires. The objective of the present study was the genetic characterization of Brazilian Leptospira sp. isolates obtained from wild and domestic animals. The genotyping of the strains was performed by the VNTR technique, using the L...
May 19, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29773482/a-model-for-leptospire-dynamics-and-control-in-the-norway-rat-rattus-norvegicus-the-reservoir-host-in-urban-slum-environments
#2
Amanda Minter, Peter J Diggle, Federico Costa, James Childs, Albert I Ko, Mike Begon
Leptospirosis is a zoonosis that humans can contract via contact with animal reservoirs directly or with water contaminated with their urine. The primary reservoir of pathogenic leptospires within urban slum environments is the Norway rat (Rattus norvegicus). Motivated by the annual outbreaks of human leptospirosis in slum urban settings, the within population infection dynamics of the Norway rat were investigated in Pau da Lima, an community in Salvador, Brazil. A mechanistic model of the dynamics of leptospire infection was informed by extensive field and laboratory data was developed and explored analytically...
May 5, 2018: Epidemics
https://www.readbyqxmd.com/read/29768596/sociodemographic-and-environmental-analysis-for-the-occurrence-of-anti-leptospira-antibodies-in-dogs-of-teresina-piau%C3%A3-brazil
#3
Elís Rosélia Dutra de Freitas Siqueira Silva, Vanessa Castro, Ana Lys Bezerra Barradas Mineiro, Maria das Graças Prianti, Gustavo Henrique Chaves Martins, Misael das Virgens Santana, Lucas Moreira Brito, Silvana Maria Medeiros de Sousa Silva
Leptospirosis is a worldwide zoonosis whose transmission is interlinked by multiple factors in the man-animal-ecosystem interface. This study aimed to evaluate the risk factors for the occurrence of anti-Leptospira antibodies in dogs in the capital Teresina (PI), and to determine their spatial distribution. Five hundred fifty-eight dog blood samples were submitted to the Microscopic Serum Agglutination (MSA) test. We applied semi-structured questionnaires to dog owners and obtained the area of residence for projection in geographical maps...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29768448/urinary-shedding-of-pathogenic-leptospira-in-stray-dogs-and-cats-algiers-a-prospective-study
#4
Sara Zaidi, Amar Bouam, Amina Bessas, Djamila Hezil, Hicham Ghaoui, Khatima Ait-Oudhia, Michel Drancourt, Idir Bitam
BACKGROUND: Leptospirosis is an important worldwide zoonosis. This disease is caused by pathogenic species of the genus Leptospira which are maintained in the environment via chronic renal infection of carrier animals which can be asymptomatic excretors of the organisms in their urines and become a source of infection for humans and other hosts. The prevalence of animal leptospirosis in Algiers, Algeria, is unknown. METHODOLOGY/PRINCIPAL FINDINGS: Real-time PCR and standard PCR and sequencing were used to detect pathogenic Leptospira organisms in the urines of stray dogs and cats in Algiers...
2018: PloS One
https://www.readbyqxmd.com/read/29768127/an-evaluation-of-removal-trapping-to-control-rodents-inside-homes-in-a-plague-endemic-region-of-rural-northwestern-uganda
#5
Rebecca J Eisen, Linda A Atiku, Karen A Boegler, Joseph T Mpanga, Russell E Enscore, Katherine MacMillan, Kenneth L Gage
Rodents pose a significant threat to human health, particularly in rural subsistence farming communities in Africa, where rodents threaten food security and serve as reservoirs of human pathogens, including the agents of plague, leptospirosis, murine typhus, rat-bite fever, Lassa fever, salmonellosis, and campylobacteriosis. Our study focused on the plague-endemic West Nile region of Uganda, where a majority of residents live in Uganda government-defined poverty, rely on subsistence farming for a living, and frequently experience incursions of rodents into their homes...
May 16, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29765361/biodiversity-of-environmental-leptospira-improving-identification-and-revisiting-the-diagnosis
#6
Roman Thibeaux, Dominique Girault, Emilie Bierque, Marie-Estelle Soupé-Gilbert, Anna Rettinger, Anthony Douyère, Michael Meyer, Gregorio Iraola, Mathieu Picardeau, Cyrille Goarant
Leptospirosis is an important environmental disease and a major threat to human health causing at least 1 million clinical infections annually. There has recently been a growing interest in understanding the environmental lifestyle of Leptospira . However, Leptospira isolation from complex environmental samples is difficult and time-consuming and few tools are available to identify Leptospira isolates at the species level. Here, we propose a polyphasic isolation and identification scheme, which might prove useful to recover and identify environmental isolates and select those to be submitted to whole-genome sequencing...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29761761/leptospirosis-among-returned-travelers-a-geosentinel-site-survey-and-multicenter-analysis-1997-2016
#7
Sophia G de Vries, Benjamin J Visser, Rhett J Stoney, Jiri F P Wagenaar, Emmanuel Bottieau, Lin H Chen, Annelies Wilder-Smith, Mary Wilson, Christophe Rapp, Karin Leder, Eric Caumes, Eli Schwartz, Noreen A Hynes, Abraham Goorhuis, Douglas H Esposito, Davidson H Hamer, Martin P Grobusch, For The GeoSentinel Surveillance Network
Leptospirosis is a potentially fatal emerging zoonosis with worldwide distribution and a broad range of clinical presentations and exposure risks. It typically affects vulnerable populations in (sub)tropical countries but is increasingly reported in travelers as well. Diagnostic methods are cumbersome and require further improvement. Here, we describe leptospirosis among travelers presenting to the GeoSentinel Global Surveillance Network. We performed a descriptive analysis of leptospirosis cases reported in GeoSentinel from January 1997 through December 2016...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29758037/a-systematic-review-of-human-and-animal-leptospirosis-in-the-pacific-islands-reveals-pathogen-and-reservoir-diversity
#8
Vanina Guernier, Cyrille Goarant, Jackie Benschop, Colleen L Lau
BACKGROUND: The Pacific Islands have environmental conditions highly favourable for transmission of leptospirosis, a neglected zoonosis with highest incidence in the tropics, and Oceania in particular. Recent reports confirm the emergence and outbreaks of leptospirosis in the Pacific Islands, but the epidemiology and drivers of transmission of human and animal leptospirosis are poorly documented, especially in the more isolated and less developed islands. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a systematic review of human and animal leptospirosis within 25 Pacific Islands (PIs) in Polynesia, Melanesia, Micronesia, as well as Easter Island and Hawaii...
May 14, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29755425/identification-and-characterization-of-c-di-gmp-metabolic-enzymes-of-leptospira-interrogans-and-c-di-gmp-fluctuations-after-thermal-shift-and-infection
#9
Guohui Xiao, Liangliang Kong, Rongbo Che, Yusi Yi, Qinchao Zhang, Jie Yan, Xu'ai Lin
Leptospirosis is a widespread zoonotic disease caused by pathogenic Leptospira species. The most common species, Leptospira interrogans , can transfer from contaminated soil or water to the human body. It is able to survive these changing environments through sensing and responding to the changes of environmental cues. Cyclic di-GMP (c-di-GMP) is a special secondary messenger in bacteria, which can respond to the environment and regulate diverse bacterial behaviors. The c-di-GMP levels in bacterial cells are regulated by diguanylatecyclases (DGC) and phosphodiesterases (PDE), which are responsible for synthesizing or hydrolyzing c-di-GMP, respectively...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29753855/travel-related-leptospirosis-in-the-netherlands-2009-2016-an-epidemiological-report-and-case-series
#10
Sophia G de Vries, Maud M I Bekedam, Benjamin J Visser, Cornelis Stijnis, Pieter P A M van Thiel, Michèle van Vugt, Abraham Goorhuis, Jiri F P Wagenaar, Martin P Grobusch, Marga G A Goris
BACKGROUND: Leptospirosis is a potentially fatal zoonotic disease that is prevalent in travellers. Here, we describe epidemiological and diagnostic characteristics of all returning travellers diagnosed with leptospirosis in the Netherlands between 2009 and 2016. Furthermore, we present a detailed clinical case series of all travellers with leptospirosis who presented at the Academic Medical Center (AMC) in the same period. METHOD: We extracted data from the records of the Dutch Leptospirosis Reference Center (NRL) of all cases of leptospirosis in travellers in the Netherlands from 2009-2016...
May 10, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29749356/advances-challenges-in-leptospiral-vaccine-development
#11
REVIEW
Garba Bashiru, Abdul Rani Bahaman
Considerable progress has been made in the field of leptospiral vaccines development since its first use as a killed vaccine in guinea pigs. Despite the fact that the immunity conferred is restricted to serovars with closely related lipopolysaccharide antigen, certain vaccines have remained useful, especially in endemic regions, for the protection of high-risk individuals. Other conventional vaccines such as the live-attenuated vaccine and lipopolysaccharide (LPS) vaccine have not gained popularity due to the reactive response that follows their administration and the lack of understanding of the pathogenesis of leptospirosis...
January 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29741518/challenges-in-the-diagnosis-of-leptospirosis-outwith-endemic-settings-a-scottish-single-centre-experience
#12
C D Russell, M E Jones, D T O'Shea, K J Simpson, A Mitchell, I F Laurenson
Background Leptospirosis is a zoonotic infection occurring worldwide but endemic in tropical countries. This study describes diagnostic testing for leptospirosis at our institution in Scotland over a 10-year period. Method We identified patients with blood samples referred to the Public Health England reference laboratory for leptospirosis testing between 2006 and 2016. Results A total of 480 samples were sent for IgM ELISA testing with 26 positive results from 14 patients. Two patients met criteria for 'confirmed' leptospirosis (microscopic agglutination test > 1:320 in one case and a positive PCR in the other) and the remaining 12 were 'probable' on the basis of IgM ELISA positivity, though 9 did not have microscopic agglutination testing performed...
March 2018: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29734328/knowledge-attitudes-and-practices-kap-regarding-leptospirosis-among-residents-of-riverside-settlements-of-santa-fe-argentina
#13
Tamara Ricardo, Laura C Bergero, Esteban P Bulgarella, M Andrea Previtali
BACKGROUND: Leptospirosis is a global and re-emerging zoonotic disease caused by Leptospira spirochetes that are shed into the environment by infected animals. Humans can get infected via contact with animal hosts or contaminated environment. In Argentina, the highest annual incidences were reported in the province of Santa Fe, where epidemic outbreaks occurred during flooding events. This study examined the knowledge, attitudes and practices (KAP) regarding leptospirosis among residents of riverside slum settlements from Santa Fe after a major flood...
May 7, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29724267/demographic-clinical-and-laboratory-features-of-leptospirosis-and-dengue-co-infection-in-malaysia
#14
Munirah Hishamshah, Norazah Ahmad, Hishamshah Mohd Ibrahim, Nurul Atiqah Nur Halim, Salbiah Nawi, Fairuz Amran
PURPOSE: In this study, we aim to describe and compare the demographical, clinical and laboratory features of leptospirosis and dengue co-infections (LDCI) against single leptospirosis infections in Malaysia. METHODOLOGY: Data of patients admitted to various hospitals in Malaysia from 2011 to 2015 diagnosed with leptospirosis in our laboratory were obtained from their admission records. Co-infection with dengue was determined by collecting dengue serology results...
May 4, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29721805/leptospirosis-is-strongly-associated-to-estrus-repetition-on-cattle
#15
H A Libonati, G B Santos, G N Souza, F Z Brandão, W Lilenbaum
Although prevalent, the exact impact of infectious diseases on reproductive failures remains to be determined. Among them, leptospirosis has commonly been reported as cause of abortions on outbreaks. Nevertheless, the majority of the animals present a chronic, silent form of the disease, which is characterized by low reproductive efficiency and is frequently neglected. In that context, we conducted a study that aims to estimate the impact of chronic leptospirosis on reproductive disorders on cattle. A total of 25 different dairy herds with history of reproductive losses from Rio de Janeiro, Brazil, were selected...
May 2, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29720698/exploring-leptospiral-proteomes-to-identify-potential-candidates-for-vaccine-design-against-leptospirosis-using-an-immunoinformatics-approach
#16
Kumari Snehkant Lata, Swapnil Kumar, Vibhisha Vaghasia, Priyanka Sharma, Shivarudrappa B Bhairappanvar, Subhash Soni, Jayashankar Das
Leptospirosis is the most widespread zoonotic disease, estimated to cause severe infection in more than one million people each year, particularly in developing countries of tropical areas. Several factors such as variable and nonspecific clinical manifestation, existence of large number of serovars and asymptomatic hosts spreading infection, poor sanitation and lack of an effective vaccine make prophylaxis difficult. Consequently, there is an urgent need to develop an effective vaccine to halt its spread all over the world...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29709286/use-of-geographically-weighted-logistic-regression-to-quantify-spatial-variation-in-the-environmental-and-sociodemographic-drivers-of-leptospirosis-in-fiji-a-modelling-study
#17
Helen J Mayfield, John H Lowry, Conall H Watson, Mike Kama, Eric J Nilles, Colleen L Lau
BACKGROUND: Leptospirosis is a globally important zoonotic disease, with complex exposure pathways that depend on interactions between human beings, animals, and the environment. Major drivers of outbreaks include flooding, urbanisation, poverty, and agricultural intensification. The intensity of these drivers and their relative importance vary between geographical areas; however, non-spatial regression methods are incapable of capturing the spatial variations. This study aimed to explore the use of geographically weighted logistic regression (GWLR) to provide insights into the ecoepidemiology of human leptospirosis in Fiji...
May 2018: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29703874/cytokine-profile-of-patients-with-leptospirosis-in-sabah-malaysia
#18
B J Mohd Iskandar, T William, J Daisy Vanitha
BACKGROUND: Leptospirosis is a zoonotic disease with symptoms ranging from a mild, febrile illness to a severe form with multiorgan failure. Severe leptospirosis may require medical interventions in the form of dialysis and/or mechanical ventilation and often leads to mortality. An exaggerated host immune response-in particular, a "cytokine storm"-that causes endothelial and organ damage is associated with the disease severity and mortality. METHODS: Microscopic agglutination test (MAT)-positive and MAT-negative human serum samples (n=30) from patients with leptospirosis were obtained from the Public Health Laboratory, Kota Kinabalu, Sabah, Malaysia and control serum samples (n=10) were obtained from healthy student volunteers...
April 2018: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29703737/quantitative-survival-of-leptospira-interrogans-in-soil-and-water-microcosms
#19
Arnau Casanovas-Massana, Gabriel Ghizzi Pedra, Elsio A Wunder, Peter J Diggle, Mike Begon, Albert I Ko
Leptospira interrogans is the etiological agent of leptospirosis, a globally distributed zoonotic disease. Human infection usually occurs through skin exposure with water and soil contaminated with the urine of chronically infected animals. In this study, we aimed to quantitatively characterize the survival of Leptospira interrogans serovar Copenhageni in environmental matrices. We constructed laboratory microcosms to simulate natural conditions and determined the persistence of DNA markers in soil, mud, spring water and sewage using a qPCR and a PMA-qPCR assay...
April 27, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29696440/leptospiral-genomics-and-pathogenesis
#20
Dieter Bulach, Ben Adler
Until about 15 years ago, the molecular and cellular basis for pathogenesis in leptospirosis was virtually unknown. The determination of the first full genome sequence in 2003 was followed rapidly by other whole genome sequences, whose availability facilitated the development of transposon mutagenesis and then directed mutagenesis of pathogenic Leptospira spp. The combination of genomics, transcriptomics and mutant construction and characterisation has resulted in major progress in our understanding of the taxonomy and biology of Leptospira...
April 26, 2018: Current Topics in Microbiology and Immunology
keyword
keyword
67099
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"