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steroids in twin pregnancy

W R Allen, S Wilsher
Over the past 50 years, per season pregnancy rate in Thoroughbred mares have risen from 70 to >90% and foaling rates from 55 to >80%. Some of the significant pharmacological treatments and diagnostic methods which have driven this marked improvement in breeding efficiency are reviewed. They include the application of artificial lighting to hasten the onset of ovulatory oestrous cyclicity in early Spring, rapid steroid hormone assays to aid in determining the stage and normality of the mare's cycle, prostaglandin analogues, synthetic progestagens and Gonadotrophin-releasing Hormone (GnRH) analogues to better control and manipulate her cycle to good effect, transrectal ultrasound scanning to monitor follicle growth, endometrial architecture and ovulation and to allow accurate, early pregnancy diagnosis thereby enabling successful ablation of one of twin conceptuses...
January 2018: Equine Veterinary Journal
Everett F Magann, Kjell Haram, Songthip Ounpraseuth, Jan H Mortensen, Horace J Spencer, John C Morrison
The aim of this study was to determine, in pregnancies complicated by preterm premature rupture of membranes (PPROM), hypertension, intrauterine growth restriction, multi-fetal gestations and pregnancies 23-26 weeks and ≥34 weeks' gestation, whether antenatal corticosteroids benefit the fetus. Literature review using PubMed, Web of Science, Clinical, Cochrane Database of Systematic Reviews (1990-2015). Search terms linked special circumstances with corticosteroids. Randomized clinical trials, retrospective and prospective cohort studies, and case control studies were reviewed...
April 2017: Acta Obstetricia et Gynecologica Scandinavica
Pauline Orquevaux, Agathe Masseau, Véronique Le Guern, Vanessa Gayet, Danièle Vauthier, Gaelle Guettrot-Imbert, Du Le Thi Huong, Bertrand Wechsler, Nathalie Morel, Patrice Cacoub, Jean-Loup Pennaforte, Jean-Charles Piette, Nathalie Costedoat-Chalumeau
OBJECTIVE: To compile and assess data about complication and success rates for in vitro fertilization (IVF) of women with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). To date, such data are sparse. METHODS: This retrospective study described women with SLE and/or APS who have had at least 1 IVF cycle. RESULTS: Thirty-seven women with SLE (n = 23, including 8 with antiphospholipid antibodies), SLE with APS (n = 4), or primary APS (n = 10) underwent 97 IVF procedures...
May 2017: Journal of Rheumatology
J N Roberts, K J May, A Veiga-Lopez
The ruminant placenta functions as an endocrine and paracrine organ secreting proteins, growth factors, and steroid hormones, including pregnancy-associated glycoproteins (PAG), proteins with elusive function, which are readily detectable in maternal serum after placental attachment. In sheep, circulating progesterone beyond gestational Day 50 is predominantly of placental origin. The relationship among placental secreted factors, including progesterone, remains uncertain in sheep. The first aim of the study was to determine the relationship between gestational PAG profiles-using two commercial ELISA assays-progesterone, and fetal growth during pregnancy...
February 2017: Theriogenology
Pedro Brandão, Bárbara Sousa-Faria, Carla Marinho, Pedro Vieira-Enes, Anabela Melo, Lurdes Mota
Polymorphic Eruption of Pregnancy (PEP) is one of the most common dermatosis related to pregnancy. PEP usually consists of pruritic papules and plaques appearing in the third trimester of pregnancy. It is more common in primigravidae and twin pregnancies. Although not associated with poorer foetal or maternal outcomes, it may be hard for pregnant women to endure. The diagnosis is easy if suspected, though sometimes it may be hard to distinguish from other dermatosis such as atopic eczema of pregnancy, pemphigoid gestationis or dermatitis...
February 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Muren, Satoshi Kusuda, Osamu Doi, Hitomi Naito, Hisashi Hashikawa
The purpose of this study was to evaluate the reproductive status and clarify the reproductive physiology of captive Sichuan golden monkeys. The concentrations of urinary estradiol-3-glucuronide (E2 G) and pregnanediol-glucuronide (PdG) or fecal estradiol-17β (E2 ) and PdG in two females, and fecal testosterone concentrations in a male, were measured continuously using enzyme immunoassays. On the basis of these hormone profiles, the follicular phase, luteal phase, and ovarian cycle were calculated to be 14...
January 1, 2017: Theriogenology
Ami Nagashima, Shigeru Aoki, Kazuo Seki, Fumiki Hirahara
In patients with bloody amniotic fluid, expectant management for chronic abruption is difficult and should not be applied except after a 48-h waiting period required for administration of steroids.
April 2016: Clinical Case Reports
Esther A M Kuijper, Jos W R Twisk, Ted Korsen, Mirte R Caanen, Mark M Kushnir, Alan L Rockwood, A Wayne Meikle, Peter G Hompes, Jan M Wit, Cornelis B Lambalk
OBJECTIVE: To answer the questions: Are perinatal reproductive hormone profiles different in case of a twin compared with a singleton pregnancy? Are reproductive endocrine profiles of twin girls influenced by their male co-twin and vice versa? DESIGN: Prospective cohort study from January 2004 to October 2009. SETTING: Not applicable. PATIENT(S): A total of 204 mothers of twins and 248 singleton control subjects, aged >18 years, pregnant with a twin or singleton and no endocrine disease or malignancy...
December 2015: Fertility and Sterility
Hiroomi Okuyama, Satoko Ohfuji, Masahiro Hayakawa, Naoto Urushihara, Akiko Yokoi, Hiroshi Take, Jun Shiraishi, Hideshi Fujinaga, Kensuke Ohashi, Kyoko Minagawa, Maiko Misaki, Satoko Nose, Tomoaki Taguchi
BACKGROUND: Very low-birthweight (VLBW) infants (VLBWI) are at increased risk for surgical intestinal disorders including necrotizing enterocolitis (NEC), focal intestinal perforation (FIP) and meconium-related ileus (MRI). The aim of this study was to identify disease-specific risk factors for surgical intestinal disorders in VLBWI. METHODS: A retrospective multicenter case-control study was conducted at 11 institutes. We reviewed VLBWI who underwent laparotomy for intestinal disorders including perforation and intractable bowel obstruction...
January 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Lefevre Claire, Rachel Vieux
OBJECTIVE: The aim of this study is to evaluate the impact of multiple pregnancies, maternal obesity, and preeclampsia on the effect of antenatal steroids on neonatal respiratory distress syndrome (RDS). STUDY DESIGN: The retrospective cohort study was performed in a level III maternity ward. Population was composed of mother-infant pairs. We included inborn infants < 34 weeks gestation, hospitalized in our neonatal intensive care unit, and mothers delivering before 34 weeks gestation and hospitalized before delivery...
September 2015: American Journal of Perinatology
Maruša Herzog, Lilijana Kornhauser Cerar, Tanja Premru Sršen, Ivan Verdenik, Miha Lučovnik
OBJECTIVE: Periventricular leukomalacia (PVL) is a neonatal brain white matter injury associated with development of cerebral palsy, intellectual impairment, and visual disturbances. PVL is more common in premature neonates. Our objective was to examine the impact of several potential risk factors other than prematurity on the incidence of PVL. STUDY DESIGN: A case-control study based on the Slovenian National Perinatal Information System data for the period 2002-2011...
April 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Lokiny Gnanendran, Barbara Bajuk, Julee Oei, Kei Lui, Mohamed E Abdel-Latif
OBJECTIVE: To study the neurodevelopmental outcomes of multiple (twins, triplets, quads) compared with singleton extremely preterm infants <29 weeks gestation. DESIGN: Population-based retrospective cohort study. SETTING: A network of 10 neonatal intensive care units in a geographically defined area of New South Wales and the Australian Capital territory. PATIENTS: 1473 infants <29 weeks gestation born between 1 January 1998 and 31 December 2004...
March 2015: Archives of Disease in Childhood. Fetal and Neonatal Edition
Anu Raevuori, Milla S Linna, Anna Keski-Rahkonen
OBJECTIVE: The objective of this descriptive review is to summarize the current scientific evidence on various prenatal and perinatal exposures affecting later development of eating disorders among offspring. METHOD: Studies were searched from PubMed database with the following keywords: eating disorders and disordered eating and anorexia nervosa and bulimia nervosa and binge eating disorder and prenatal exposure delayed effects and maternal exposure and perinatology...
November 2014: International Journal of Eating Disorders
Giovanni Casella, Vincenzo Villanacci, Elisabetta Antonelli, Camillo Di Bella, Vittorio Baldini, Mohammad Rostami Nejad, Gabrio Bassotti
Inflammatory bowel disease (IBD) frequently affects young patients of childbearing age. Treatments for inflammatory bowel disease include immunosuppressive, cytotoxic and surgical therapies. Azathioprine is frequently used to treat patients with steroid dependent IBD. We report the case of a patient with ulcerative colitis, treated with azathioprine prior to conception and during the subsequent pregnancy with the subsequent successful delivery of healthy twins. Although some potential risks indeed exist, the use of AZA may not be harmful to the mother or the fetus in many instances...
2011: Gastroenterology and Hepatology From Bed to Bench
S Klein, C Schmidt, P La Rosée, M Pletz, S Harz, O Dirsch, M Fritzenwanger, A Stallmach
Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal hyperinflammatory syndrome characterized by fever, cytopenia, dramatically increased ferritin and hepatosplenomegaly. Here, we describe a previously healthy 39 year old pregnant woman in 30th week of her pregnancy with diarrhoea, intermittent gastrointestinal bleeding and fever of unknown focus. After cesarean section of twins in the 31st week she deteriorated with fulminant upper and lower gastrointestinal bleeding and disseminated intravascular coagulation...
April 2014: Zeitschrift Für Gastroenterologie
P Y Aad, S E Echternkamp, L J Spicer
Abundance of IGF-2 receptor (IGF2R), FSH receptor (FSHR), and LH receptor (LHCGR) mRNA in granulosa cells (GCs) or theca cells (TCs) or both cells as well as estradiol (E2), progesterone (P4), and androstenedione concentrations in follicular fluid were compared in cows genetically selected (Twinner) or not selected (control) for multiple ovulations and twin births. Cows were slaughtered at day 3 to 4 (day 3) and day 5 to 6 (day 5) of an estrous cycle, and ovaries, follicular fluid, GCs, and TCs were collected...
November 2013: Domestic Animal Endocrinology
Katarzyna Kosińska-Kaczyńska, Iwona Szymusik, Bartosz Kaczyński, Dorota Bomba-Opoń, Piotr Wegrzyn, Bohdan Dźwigała, Mirosław Wielgoś
OBJECTIVES: To evaluate data regarding neonatal mortality and short term morbidity among iatrogenic late preterm (ILP) and spontaneous late preterm (SLP) twin births, and to estimate whether medical interventions - induction of labor in this particular context, are associated with better or poorer outcomes. MATERIAL AND METHODS: Retrospective analysis of 110 late preterm dichorionic twin pregnancies was performed basing on medical charts data. All twins were delivered in years 2005-2011 at the 1st Department of Obstetrics and Gynecology Medical University of Warsaw Late preterm twins, defined as those delivered between 34 + 0-36+ 6 weeks of gestation, were divided into spontaneous and iatrogenic preterm births...
June 2013: Ginekologia Polska
Joseph J Noh, Cheol-Ho Park, Mi-Hyun Jo, Ja-Young Kwon
BACKGROUND: Unscarred uterine rupture in association with systemic lupus erythematosus (SLE) and long-term steroid treatment is rare. CASE: A 36-year-old primigravid woman conceived a twin gestation after in vitro fertilization therapy. At 23 weeks of gestation, she was found to have a spontaneous rupture of the uterus. Her medical history was significant for SLE for a duration of 19 years, and her condition had been maintained with prednisolone. She had no history of uterine scarring or other known risk factors for uterine rupture...
August 2013: Obstetrics and Gynecology
Caroline A Crowther, Jane E Harding, Philippa F Middleton, Chad C Andersen, Pat Ashwood, Jeffrey S Robinson
BACKGROUND: Both dexamethasone and betamethasone, given to women at risk of preterm birth, substantially improve short-term neonatal health, increase the chance of the baby being discharged home alive, and reduce childhood neurosensory disability, remaining safe into adulthood. However, it is unclear which corticosteroid is of greater benefit to mother and child.This study aims to determine whether giving dexamethasone to women at risk of preterm birth at less than 34 weeks' gestation increases the chance of their children surviving free of neurosensory disability at two years' corrected age, compared with betamethasone...
May 3, 2013: BMC Pregnancy and Childbirth
Mitsuhiro Kawata
Fetuses positioned next to littermates of the opposite sex may develop different sexually related traits and aggressive behaviour in later life. These effects of intrauterine position are due to hormonal transfer between fetuses. Testosterone from a male fetus that crosses the fetal membrane of an adjacent female fetus can affect molecular events in the female including modification of the steroid hormone receptors in hypothalamic neurons. The intrauterine environment may also account for the variability of laboratory animals and newborn human twins...
April 2013: Journal of Neuroendocrinology
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