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Foot and anke

Daniel Niederer, Anke Bumann, Yvonne Mühlhauser, Mareike Schmitt, Katja Wess, Tobias Engeroff, Jan Wilke, Lutz Vogt, Winfried Banzer
BACKGROUND: Mobile phone tasks like texting, typing, and dialling during walking are known to impact gait characteristics. Beyond that, the effects of performing smartphone-typical actions like researching and taking self-portraits (selfie) on gait have not been investigated yet. RESEARCH QUESTION: We aimed to investigate the effects of smartphone usage on relevant gait characteristics and to reveal potential association of basic cognitive and walking plus smartphone dual-task abilities...
April 6, 2018: Gait & Posture
Joan K Morris, Anna L Springett, Ruth Greenlees, Maria Loane, Marie-Claude Addor, Larraitz Arriola, Ingeborg Barisic, Jorieke E H Bergman, Melinda Csaky-Szunyogh, Carlos Dias, Elizabeth S Draper, Ester Garne, Miriam Gatt, Babak Khoshnood, Kari Klungsoyr, Catherine Lynch, Robert McDonnell, Vera Nelen, Amanda J Neville, Mary O'Mahony, Anna Pierini, Annette Queisser-Luft, Hanitra Randrianaivo, Judith Rankin, Anke Rissmann, Jennifer Kurinczuk, David Tucker, Christine Verellen-Dumoulin, Diana Wellesley, Helen Dolk
BACKGROUND: Surveillance of congenital anomalies is important to identify potential teratogens. METHODS: This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models. RESULTS: Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing...
2018: PloS One
Anke M Wijlens, Samantha Holloway, Sicco A Bus, Jaap J van Netten
Home monitoring of skin temperature is effective to prevent diabetic foot ulceration. We explored the validity of various definitions for the >2·2°C left-to-right threshold used as a warning signal for impending ulceration. Twenty patients with diabetes and peripheral neuropathy monitored their skin temperature with an infrared thermometer at the plantar hallux, metatarsal heads, midfoot and heel four times a day for 6 consecutive days. Environmental temperature and walking activity were monitored and associated with foot temperature...
December 2017: International Wound Journal
Hong Ming Huang, Denis C Bauer, Patrick M Lelliott, Matthew W A Dixon, Leann Tilley, Brendan J McMorran, Simon J Foote, Gaetan Burgio
Allelic heterogeneity is a common phenomenon where a gene exhibits a different phenotype depending on the nature of its genetic mutations. In the context of genes affecting malaria susceptibility, it allowed us to explore and understand the intricate host-parasite interactions during malaria infections. In this study, we described a gene encoding erythrocytic ankyrin-1 (Ank-1) which exhibits allelic-dependent heterogeneous phenotypes during malaria infections. We conducted an ENU mutagenesis screen on mice and identified two Ank-1 mutations, one resulting in an amino acid substitution (MRI95845), and the other a truncated Ank-1 protein (MRI96570)...
September 7, 2017: G3: Genes—Genomes—Genetics
Oliver Gottschalk, Sebastian Altenberger, Sebastian Baumbach, Stefanie Kriegelstein, Florian Dreyer, Alexander Mehlhorn, Hubert Hörterer, Andreas Töpfer, Anke Röser, Markus Walther
Autologous matrix-induced chondrogenesis (AMIC) has gained popularity in the treatment of osteochondral lesions of the talus. Previous studies have presented promising short-term results for AMIC talar osteochondral lesion repair, a 1-step technique using a collagen type I/III bilayer matrix. The aim of the present study was to investigate the mid-term effects. The 5-year results of a prospective cohort study are presented. All patients underwent an open AMIC procedure for a talar osteochondral lesion. Data analysis included general demographic data, preoperative magnetic resonance imaging findings, intraoperative details, and German version of the Foot Function Index (FFI-D) scores preoperatively and at 1 and 5 years after surgery...
June 21, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Hong Ming Huang, Denis C Bauer, Patrick M Lelliott, Andreas Greth, Brendan J McMorran, Simon J Foote, Gaetan Burgio
Genetic defects in various red blood cell (RBC) cytoskeletal proteins have been long associated with changes in susceptibility towards malaria infection. In particular, while ankyrin (Ank-1) mutations account for approximately 50% of hereditary spherocytosis (HS) cases, an association with malaria is not well-established, and conflicting evidence has been reported. We describe a novel N-ethyl-N-nitrosourea (ENU)-induced ankyrin mutation MRI61689 that gives rise to two different ankyrin transcripts: one with an introduced splice acceptor site resulting a frameshift, the other with a skipped exon...
November 16, 2016: Scientific Reports
Melanie Blaar, Armin Janß, Jasmin Dell'Anna, Anke Höllig, Klaus Radermacher, Hans Clusmann
The number and complexity of user interfaces in the OR has been considerably increasing during the last years. Moreover, increasing cost and time pressure force surgeons and surgical nurses to perform different tasks in parallel. We analyzed the workflow of 25 neurosurgical procedures with a workflow analysis tool in order to analyze the present situation in the neurosurgical OR and to identify potential use-oriented risks and to develop first proposals for respective countermeasures. Application of the navigation system, the CUSA ultrasonic aspirator, and the PACS-PC was associated with errors and resulting potential risks...
April 1, 2016: Biomedizinische Technik. Biomedical Engineering
Anke K Trilling, Thamara Hesselink, Adèle van Houwelingen, Jan H G Cordewener, Maarten A Jongsma, Sanne Schoffelen, Jan C M van Hest, Han Zuilhof, Jules Beekwilder
Sensitivity of biosensors depends on the orientation of bio-receptors on the sensor surface. The objective of this study was to organize bio-receptors on surfaces in a way that their analyte binding site is exposed to the analyte solution. VHH proteins recognizing foot-and-mouth disease virus (FMDV) were used for making biosensors, and azides were introduced in the VHH to function as bioorthogonal reactive groups. The importance of the orientation of bio-receptors was addressed by comparing sensors with randomly oriented VHH (with multiple exposed azide groups) to sensors with uniformly oriented VHH (with only a single azide group)...
October 15, 2014: Biosensors & Bioelectronics
Roelof Waaijman, Mirjam de Haart, Mark L J Arts, Daniel Wever, Anke J W E Verlouw, Frans Nollet, Sicco A Bus
OBJECTIVE: Recurrence of plantar foot ulcers is a common and major problem in diabetes but not well understood. Foot biomechanics and patient behavior may be important. The aim was to identify risk factors for ulcer recurrence and to establish targets for ulcer prevention. RESEARCH DESIGN AND METHODS: As part of a footwear trial, 171 neuropathic diabetic patients with a recently healed plantar foot ulcer and custom-made footwear were followed for 18 months or until ulceration...
June 2014: Diabetes Care
Anke K Trilling, Michiel M Harmsen, Vincent J B Ruigrok, Han Zuilhof, Jules Beekwilder
Uniform orientation of capture molecules on biosensors has been reported to increase sensitivity. Here it is investigated which analyte properties contribute to sensitivity by orientation. Orientation of capture molecules on biosensors was investigated using variable domains of llama heavy-chain antibodies (VHHs) as capture molecule, and a surface plasmon resonance (SPR) chip as biosensor. Two VHHs were tested in this study: one recognizing foot-and-mouth disease virus (FMDV) and another recognizing the 16 kDa heat-shock protein of Mycobacterium tuberculosis...
February 15, 2013: Biosensors & Bioelectronics
Andreas Greth, Shelley Lampkin, Preethi Mayura-Guru, Fleur Rodda, Karen Drysdale, Meredith Roberts-Thomson, Brendan J McMorran, Simon J Foote, Gaétan Burgio
The blood stage of the plasmodium parasite life cycle is responsible for the clinical symptoms of malaria. Epidemiological studies have identified coincidental malarial endemicity and multiple red blood cell (RBC) disorders. Many RBC disorders result from mutations in genes encoding cytoskeletal proteins and these are associated with increased protection against malarial infections. However the mechanisms underpinning these genetic, host responses remain obscure. We have performed an N-ethyl-N-nitrosourea (ENU) mutagenesis screen and have identified a novel dominant (haploinsufficient) mutation in the Ank-1 gene (Ank1(MRI23420)) of mice displaying hereditary spherocytosis (HS)...
2012: PloS One
Anke I R Kottink, Hendrik P J Buschman, Laurence P J Kenney, Peter H Veltink, Per Slycke, Gerrit Bultstra, Hermie J Hermens
The objective of this study was to evaluate the stimulation responses on each channel of an implantable two-channel stimulator that stimulates the peroneal nerve branches innervating the muscles for dorsiflexion and eversion movements. Currently five Dutch patients and five English patients have been implanted with this system. Isometric ankle torque measurements were carried out in the patient with the longest follow-up period (1 y). A force sensor measured the three components of moment generated at the ankle joint...
October 2004: Neuromodulation: Journal of the International Neuromodulation Society
Anke I R Kottink, Martin J B Tenniglo, Wiebe H K de Vries, Hermie J Hermens, Jaap H Buurke
OBJECTIVE: The aims of this study were: (i) to compare the neuro-prosthetic effect of implantable peroneal nerve stimulation to the orthotic effect of a standard of care intervention (no device, shoe or ankle foot orthosis) on walking, as assessed by spatiotemporal parameters; and (ii) to examine whether there is evidence of an enhanced lower-limb flexion reflex with peroneal nerve stimulation and compare the kinematic effect of an implantable peroneal nerve stimulation device vs standard of care intervention on initial loading response of the paretic limb, as assessed by hip, knee and ankle kinematics...
January 2012: Journal of Rehabilitation Medicine
Constantijn E V B Hazenberg, Sicco A Bus, Anke I R Kottink, Clazien A M Bouwmans, Anna M Schönbach-Spraul, Sjef G van Baal
We assessed the feasibility of using a photographic foot imaging device (PFID) as a tele-monitoring tool in the home environment of patients with diabetes who were at high risk of ulceration. Images of the plantar foot were taken three times a week over a period of four months in the home of 22 high-risk patients. The images were remotely assessed by a diabetic foot specialist. At the end of the study, 12% of images were missing, mainly due to modem or server failures (66%), or non-adherence (11%). All three referrals for diagnosed ulcers and 31 of 32 referrals for abundant callus resulted in treatment...
January 2012: Journal of Telemedicine and Telecare
Hermann O Mayr, Anna Hoell, Anke Bernstein, Robert Hube, Claudius Zeiler, Thomas Kalteis, Norbert P Suedkamp, Amelie Stoehr
PURPOSE: A test setup for clinical use in the awake and non-anesthetized patient measuring anteroposterior translation and rotation of the knee joint is the subject of validation. METHODS: A measuring device featuring fixation of the foot at 30° of knee flexion with varus/valgus stress posts for the knee was developed. Tibial rotation (external/internal) was imposed with a torque of 2 Nm on the footrest with the ankle locked in dorsiflexion. Anterior translation of the tibia in relation to the femur was measured with a commercially available arthrometer...
August 2011: Arthroscopy: the Journal of Arthroscopic & related Surgery
Anita E Williams, Christopher J Nester, Michael I Ravey, Anke Kottink, Morey-Gaspar Klapsing
BACKGROUND: Therapeutic footwear is recommended for those people with severe foot problems associated with rheumatoid arthritis (RA). However, it is known that many do not wear them. Although previous European studies have recommended service and footwear design improvements, it is not known if services have improved or if this footwear meets the personal needs of people with RA. As an earlier study found that this footwear has more impact on women than males, this study explores women's experiences of the process of being provided with it and wearing it...
2010: Journal of Foot and Ankle Research
Anke I Kottink, Maarten J Ijzerman, Catharina G Groothuis-Oudshoorn, Hermie J Hermens
The aim was to determine if the treatment of a drop foot by means of an implantable two-channel peroneal nerve stimulator improves health-related quality of life (HRQoL). All subjects were measured at baseline and after a follow-up period of 12 and 26 weeks. Twenty-nine stroke survivors with chronic hemiplegia with drop foot who fulfilled the predefined inclusion and exclusion criteria were included in the present randomized controlled trial. The intervention group received an implantable two-channel peroneal nerve stimulator for correction of their drop foot...
May 2010: Artificial Organs
Tanja Trarbach, Anke Reinacher-Schick, Susanne Hegewisch-Becker, Udo Vanhoefer, Thomas Frieling, Lasse Lehnert, Wolff Schmiegel, Ullrich Graeven
BACKGROUND: This phase I/II study was conducted to assess the maximal tolerated dose (MTD) and the dose-limiting toxicities (DLTs) of gefitinib in combination with capecitabine in patients with advanced colorectal cancer (aCRC). PATIENTS AND METHODS: After failure of a 1st-line therapy, patients with aCRC received escalating doses of gefitinib once daily in combination with capecitabine twice daily: dose level (DL) 1: gefitinib 250 mg and capecitabine 1,000 mg/m(2), DL 2: gefitinib 250 mg and capecitabine 1,250 mg/m(2), DL 3: gefitinib 500 mg and capecitabine 850 mg/m(2)...
2010: Onkologie
Christof Kloos, Franziska Hagen, Claudia Lindloh, Anke Braun, Karena Leppert, Nicolle Müller, Gunter Wolf, Ulrich A Müller
OBJECTIVE: To study whether there is an association between cognitive impairment and the relapse rate of foot ulcers in diabetic patients and those with previous foot ulcers. RESEARCH DESIGN AND METHODS: This single-center prospective study assessed the association of cognitive function and risk for ulcer relapse in 59 patients with diabetes (mean age 65.1 years, diabetes duration 16.5 years, and A1C 7.4%), peripheral neuropathy, and a history of foot ulceration...
May 2009: Diabetes Care
Gerhard Rank, Rosemary Sutton, Vikki Marshall, Rachel J Lundie, Jacinta Caddy, Tony Romeo, Kate Fernandez, Matthew P McCormack, Brian M Cooke, Simon J Foote, Brendan S Crabb, David J Curtis, Douglas J Hilton, Benjamin T Kile, Stephen M Jane
Insights into the role of ankyrin-1 (ANK-1) in the formation and stabilization of the red cell cytoskeleton have come from studies on the nb/nb mice, which carry hypomorphic alleles of Ank-1. Here, we revise several paradigms established in the nb/nb mice through analysis of an N-ethyl-N-nitrosourea (ENU)-induced Ank-1-null mouse. Mice homozygous for the Ank-1 mutation are profoundly anemic in utero and most die perinatally, indicating that Ank-1 plays a nonredundant role in erythroid development. The surviving pups exhibit features of severe hereditary spherocytosis (HS), with marked hemolysis, jaundice, compensatory extramedullary erythropoiesis, and tissue iron overload...
April 2, 2009: Blood
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