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Duplex Kidney

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https://www.readbyqxmd.com/read/27923152/hydronephrosis-in-the-wnt5a-ablated-kidney-is-caused-by-an-abnormal-ureter-bladder-connection
#1
Kangsun Yun, Alan O Perantoni
The Wnt5a null mouse is a complex developmental model which, among its several posterior-localized axis defects, exhibits multiple kidney phenotypes, including duplex kidney and loss of the medullary zone. We previously reported that ablation of Wnt5a in nascent mesoderm causes duplex kidney formation as a result of aberrant development of the nephric duct and abnormal extension of intermediate mesoderm. However, these mice also display a loss of the medullary region late in gestation. We have now genetically isolated duplex kidney formation from the medullary defect by specifically targeting the progenitors for both the ureteric bud and metanephric mesenchyme...
December 3, 2016: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/27920854/recurrent-urinary-tract-infections-in-an-adult-with-a-duplicated-renal-collecting-system
#2
Junaid Raja, Amir M Mohareb, Bilori Bilori
Because of advancements in fetal imaging, anatomic variants of the genitourinary tract are most often discovered in the antenatal period. As such, general internists are less likely to encounter adult patients with previously undiagnosed anatomic abnormalities of the renal collecting system, such as duplicated kidneys. These abnormalities put patients at risk for urinary obstruction and recurrent infections of the urinary tract. We report the case of a 40-year-old diabetic patient with a previously undiagnosed duplex kidney who had recurrent episodes of diabetic ketoacidosis triggered by urinary tract infections...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27878457/poorly-understood-and-often-miscategorized-congenital-umbilical-cord-hernia-an-alternative-repair-method
#3
E İnce, A Temiz, S S Ezer, H Ö Gezer, A Hiçsönmez
PURPOSE: Umbilical cord hernia is poorly understood and often miscategorized as "omphalocele minor". Careless clamping of the cord leads to iatrogenic gut injury in the situation of umbilical cord hernia. This study aimed to determine the characteristics and outcomes of umbilical cord hernias. We also highlight an alternative repair method for umbilical cord hernias. METHODS: We recorded 15 cases of umbilical cord hernias over 10 years. The patients' data were retrospectively reviewed, and preoperative preparation of the newborn, gestational age, birth weight, other associated malformations, surgical technique used, enteral nutrition, and length of hospitalization were recorded...
November 22, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/27873231/atherosclerotic-renal-artery-stenosis
#4
Robert Schoepe, Stephen McQuillan, Debbie Valsan, Geoffrey Teehan
Atherosclerotic Renal Artery Stenosis is a form or peripheral arterial disease that tends to affect older subjects with hyperlipidemia, history of tobacco use, and who have other coexistent forms of vascular insufficiency. An abdominal bruit on physical exam can be a helpful clue. Slowly progressive, it can lead to critical narrowing of the renal arteries which creates a cascade of events such as renin-angiotensin-aldosterone activation (RAAS), hypertension, acute pulmonary edema, and renal fibrosis. The hypertension is considered a secondary form and can even be resistant to multiple antihypertensives...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27867847/retroperitoneal-and-laparoscopic-heminephrectomy-in-duplex-kidney-in-infants-and-children
#5
Ciro Esposito, Maria Escolino, Marco Castagnetti, Antonio Savanelli, Angela La Manna, Alessandra Farina, Francesco Turrà, Agnese Roberti, Alessandro Settimi, Francois Varlet, Holger Till, Jean Stephan Valla
BACKGROUND: Two main techniques are adopted to perform partial nephrectomy in children: laparoscopy and retroperitoneoscopy. The aim of this paper is to review the larger multicentric experience recently published by our group to review indications, techniques and results of both approaches. METHODS: Data of 102 patients underwent partial nephrectomy in a 5-year period using minimally invasive surgery (MIS) procedures were analyzed. Fifty-two children underwent laparoscopic partial nephrectomy (LPN), and 50 children underwent retroperitoneoscopic partial nephrectomy (RPN)...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27829833/unusual-presentation-of-duplex-kidneys-ureteropelvic-junction-obstruction
#6
Cemile Başdaş, Süleyman Çelebi, Seyithan Özaydın, Birgül Karaaslan, Elmas Reyhan Alim, Ünal Güvenç, Serdar Sander
Aim. Ureteropelvic junction obstruction (UPJO) is rarely associated with a duplex collecting system. We review this unusual anomaly in terms of presentation, diagnostic evaluation, and surgical management. Method. We retrospectively reviewed the medical records of patients diagnosed with a duplex system with UPJO. Result. Sixteen patients (6 girls, 10 boys) with 18 moieties were treated surgically and four patients were treated conservatively. The median age at surgery was two years (range, 2 months to 7 years)...
2016: Advances in Urology
https://www.readbyqxmd.com/read/27790549/ureteral-reflux-into-an-ectopic-upper-moeity-of-a-duplex-kidney-from-the-bladder-neck-with-distal-ureteral-pseudodiverticulum-formation
#7
Denver Steven Pinto, Tom George, Deepali Saxena, Thara Joseph, V Ravi Hoisala
Urinary incontinence is a condition causing significant psychological trauma and affects the quality of life of the affected individual. Though common causes of urinary incontinence of non-traumatic aetiology in young adults include detrusor instability and congenital conditions like meningomyelocoele, an ectopic ureter is an important surgically correctable cause of urinary incontinence. The cause of incontinence in an ectopic ureter is insertion of the ureter distal to the internal urethral sphincter. The authors describe a case report of an ectopic ureter arising from a duplex moiety with poor renal function using multiple modalities...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27704184/mini-percutaneous-nephrolithotomy-for-stones-in-anomalous-kidneys-a-prospective-study
#8
Sanjay Khadgi, Babu Shrestha, Hamdy Ibrahim, Sunil Shrestha, Mohammed S ElSheemy, Ahmed M Al-Kandari
To evaluate safety and efficacy of minipercutaneous nephrolithotomy (Mini-PNL) in management of stones in different types of renal anomalies. Patients with stones ≥2 cm or SWL-resistant stones in anomalous-kidneys treated by Mini-PNL between March 2010 and September 2012 were included prospectively. Mini-PNL was done under regional anesthesia in prone position with fluoroscopic guidance through 18 Fr sheath using semirigid ureteroscope (8.5/11.5 Fr) and pneumatic lithotripter. All patients were followed-up for 2-3 years...
October 4, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27695208/comparison-of-intravenous-urography-and-magnetic-resonance-urography-in-preoperative-evaluation-of-pelvi-ureteric-junction-obstruction-in-children
#9
Alok Sharma, Kushaljit Singh Sodhi, Akshay Kumar Saxena, Anmol Bhatia, Prema Menon, Katragadda L N Rao, Niranjan Khandelwal
AIMS: To compare intravenous urography (IVU) and magnetic resonance urography (MRU) in the preoperative evaluation of pelvi-ureteric junction obstruction (PUJO) in children. MATERIALS AND METHODS: A total of 35 children up to 10 years of age in whom unilateral or bilateral PUJO were suspected on ultrasonography were enrolled in this prospective study. All children underwent IVU and MRU, and the findings were compared. RESULTS: Of the 70 kidneys evaluated, 14 (20%) were not visualized on IVU because of nonexcretion of contrast, whereas all the 70 (100%) kidneys were visualized on MRU...
October 2016: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/27618805/duplex-doppler-sonography-is-there-clinical-relevance-to-elevated-renal-vein-velocity-in-kidney-transplants
#10
Mittul Gulati, Suzanne L Palmer, Michael Y Im, Hossein Jadvar, Yasir A Qazi, Umer Fazli, Edward G Grant
PURPOSE: This study aims to determine a velocity threshold in the main renal vein (MRV) of renal transplants and evaluate the cause and clinical significance of elevated velocity. METHODS: Maximum MRV velocity from 331 consecutive renal transplant Doppler ultrasounds in 170 patients was recorded. A priori, twice the median MRV velocity was selected as the threshold for elevation. Ultrasounds were divided into "early" and "late" periods based on time after transplantation...
August 26, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27572266/silencing-of-tbx20-gene-expression-in-rat-myocardial-and-human-embryonic-kidney-cells-leads-to-cell-cycle-arrest-in-g2-phase
#11
Peiyan Liu, Yueling Sun, Guangbin Qiu, Hongkun Jiang, Guangrong Qiu
Congenital heart diseases (CHDs) are the most common birth defects due to abnormal cardiac development. The T-box 20 (TBX20) gene is a member of the T‑box family of transcription factors and encodes TBX20, which is essential for early heart development. In the present study, reduced TBX20 expression was observed in CHD tissue samples compared with normal tissues, and the function of TBX20 in Rattus norvegicus myocardial cells [H9c2(2-1)] and human embryonic kidney cells (HEK293) was investigated. TBX20 was silenced in H9c2 and HEK293 cells via transfection of small interfering RNA and short hairpin RNA duplexes, respectively, and TBX20 mRNA and protein levels were subsequently examined using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blot analysis...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27545957/the-morphology-and-treatment-of-coexisting-ureteropelvic-junction-obstruction-in-lower-moiety-of-duplex-kidney
#12
Wei Liu, Liujuan Zhang, Rui Ma, Rongde Wu
BACKGROUND: Duplex kidney is a common congenital anomaly of the urinary tract, while ureteropelvic junction obstruction (UPJO) in lower unit of duplex kidney is rare. Surgical treatment can be challenging in such cases. The aim was to report our experience in managements of UPJO in lower moiety of duplex kidney. METHODS: Among the pediatric patients with duplex system from 2007-2013, 7 children were diagnosed with UPJO in lower moiety. Their medical records were retrospectively analyzed, mainly focused on anatomic aspects and operation details...
August 18, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27422246/long-term-functional-renal-outcomes-after-retroperitoneoscopic-upper-pole-heminephrectomy-for-duplex-kidney-in-children-a-multicenter-cohort-study
#13
Luc Joyeux, Isabelle Lacreuse, Anne Schneider, Raphael Moog, Josephine Borgnon, Manuel Lopez, François Varlet, François Becmeur, Emmanuel Sapin
BACKGROUND: Retroperitoneoscopic upper pole heminephrectomy (RUHN) in duplex kidney in children remains a challenging procedure with a need for postoperative functional assessment of the remnant lower pole. We aimed to calculate the incidence of long-term functional renal outcomes in these children and examine the effect of age on those outcomes. METHODS: A multicenter retrospective cohort study of 9 years included all patients undergoing RUHN and evaluated by renal ultrasound (US) and dimercaptosuccinic acid (DMSA) scintigraphy pre and postoperatively...
July 15, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27334591/analysis-of-cis-and-trans-requirements-for-dna-replication-at-the-right-end-hairpin-of-the-human-bocavirus-1-genome
#14
Weiran Shen, Xuefeng Deng, Wei Zou, John F Engelhardt, Ziying Yan, Jianming Qiu
UNLABELLED: Parvoviruses are single-stranded DNA viruses that use the palindromic structures at the ends of the viral genome for their replication. The mechanism of parvovirus replication has been studied mostly in the dependoparvovirus adeno-associated virus 2 (AAV2) and the protoparvovirus minute virus of mice (MVM). Here, we used human bocavirus 1 (HBoV1) to understand the replication mechanism of bocaparvovirus. HBoV1 is pathogenic to humans, causing acute respiratory tract infections, especially in young children under 2 years old...
September 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27321979/endovascular-treatment-of-nutcracker-syndrome
#15
Aleksandra Policha, Patrick Lamparello, Mikel Sadek, Todd Berland, Thomas Maldonado
OBJECTIVES: Nutcracker syndrome, or mesoaortic compression of the left renal vein (LRV), with associated symptoms related to venous hypertension in the left kidney, is a rare entity that may result in severe symptoms requiring operative intervention. We report on three patients who presented with nutcracker syndrome, including one patient with a circumaortic LRV resulting in posterior nutcracker syndrome, who underwent successful endovascular treatment with renal vein stenting. A review of existing literature on endovascular management of nutcracker syndrome follows...
June 16, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27318704/the-fluoro-less-and-contrast-less-peripheral-endovascular-intervention-halfway-there
#16
Georges Ephrem, Sireesha Garikipati, Ivan D Hanson
INTRODUCTION: Percutaneous endovascular revascularization requires the use of fluoroscopic guidance and radiopaque contrast. We present a successful intervention without the use of iodinated contrast. CASE: A 92-year-old man with dry gangrene involving the second and fourth left toes had acute on chronic kidney injury. Arterial duplex showed severe stenosis in bilateral superficial femoral arteries (SFAs). Fluoroscopic and ultrasound guidance and intravascular imaging were used to avoid iodinated contrast...
September 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27312756/preoperative-vessel-mapping-in-chronic-kidney-disease-patients-a-center-experience
#17
Patrícia Barreto, Paulo Almeida, Norton de Matos, José Alexandre Queirós, Joaquim Pinheiro, Fernanda Silva, Telmo Carvalho, Rui Almeida, António Cabrita
PURPOSE: Hemodialysis (HD) is the main treatment modality in stage 5 chronic kidney disease, and vascular access planning is a crucial step in the path to dialysis treatment. Beyond detailed patient history and physical examination, duplex ultrasound (DU) evaluation is essential in preoperative vascular mapping. METHODS: A retrospective descriptive nonrandomized study was performed and included 108 end-stage kidney disease patients referred from eight HD centers to be assessed for creation of an arteriovenous (AV) access (AV fistula or AV graft)...
July 12, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27304869/duplex-pcr-assay-and-in-situ-hybridization-for-detection-of-francisella-spp-and-francisella-noatunensis-subsp-orientalis-in-red-tilapia
#18
Ha T Dong, Warachin Gangnonngiw, Kornsunee Phiwsaiya, Walaiporn Charoensapsri, Vuong V Nguyen, Pål Nilsen, Padmaja J Pradeep, Boonsirm Withyachumnarnkul, Saengchan Senapin, Channarong Rodkhum
Conventional isolation and identification based on phenotypic characteristics is challenging with the highly fastidious, intracellular bacterium Francisella noatunensis subsp. orientalis (Fno). Here, we developed a duplex PCR method for simultaneous detection of the Francisella genus and Fno in one PCR reaction and an in situ hybridization method for paraffin section based diagnosis of Fno. The PCR results showed genus- and species-specific bands (1140 and 203 bp) from Fno but only one genus-specific band (1140 bp) from F...
June 15, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/27295358/beaulieu-boycott-innes-syndrome-an-intellectual-disability-syndrome-with-characteristic-facies
#19
Jillian Casey, Allan Jenkinson, Alex Magee, Sean Ennis, Ahmad Monavari, Andrew Green, Sally A Lynch, Ellen Crushell, Joanne Hughes
We report a female child from an Irish Traveller family presenting with severe intellectual disability, dysmorphic features, renal anomalies, dental caries and cyclical vomiting. Current health issues include global developmental delay, mild concentric left ventricular hypertrophy, dental malocclusion and caries and a single duplex left kidney. The proband and her mother also have multiple epiphyseal dysplasia. Whole-exome sequencing was performed to identify the underlying genetic cause. DNA from the proband was enriched with the Agilent Sure Select v5 Exon array and sequenced on an Illumina HiSeq...
October 2016: Clinical Dysmorphology
https://www.readbyqxmd.com/read/27219892/renal-artery-stenosis-are-there-patients-who-benefit-from-intervention
#20
M C Kihm, B Vogel, M Zeier, L P Kihm
Atherosclerotic renal artery stenosis (ARAS) is one of the most relevant long-term complications of atherosclerotic disease. It is associated both with hypertension and increased renal and cardiovascular risk and overall mortality. Diagnostic modalities include non-invasive duplex ultrasound, dynamic magnetic resonance angiography (MRA) and computer tomography angiography (CTA) and are confirmed by using invasive renal angiography. Percutaneous revascularization of renal artery stenosis has been studied in various clinical trials...
June 2016: Experimental and Clinical Endocrinology & Diabetes
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