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cholinergic urticaria

Tina Abraham, David P McGarry, John Frith, Jason Casselman, Haig Tcheurekdjian, Robert Hostoffer
Cold urticaria and cholinergic urticaria are two distinct entities. The presentation of exclusive cold-induced cholinergic urticaria is very rare. The patient described herein had experienced urticaria in the exclusive setting of exercising in a cold environment. Urticarial testing including laboratory and in-office testing was all negative. The patient has prevented urticaria symptoms with oral antihistamine therapy. Pure cold-induced cholinergic urticaria is rarely described in literature. This form of urticaria has yet to be described in a pediatric patient...
2016: Case Reports in Immunology
Dilek Azkur, Ersoy Civelek, Mge Toyran, Emine Dibek Msrlolu, Mustafa Erkoolu, Ayenur Kaya, Emine Vezir, Tayfur Gini, Ayegl Akan, Can Naci Kocaba
BACKGROUND: Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). OBJECTIVES: To evaluate the clinical features, possible causes, associated findings, and laboratory results of different subtypes of CU in children according to a new classification. METHODS: In this study, we evaluated the clinical features, laboratory investigations, and provocation tests of children with different subtypes of CU according to a new classification...
November 2016: Allergy and Asthma Proceedings:
Lyda Cuervo-Pardo, Alexei Gonzalez-Estrada, David M Lang
PURPOSE OF REVIEW: Physical urticaria/angioedema syndromes (PUAs) are commonly encountered. They are identified by a history of physical factors provoking cutaneous symptoms, and confirmed by provocation testing. Recent guidelines have recommended use of challenge procedures for diagnosis; however, their positive/negative likelihood ratios have not been established. RECENT FINDINGS: We conducted a systematic review to determine the diagnostic utility of recommended office procedures for three common PUAs: dermatographia (DERMATO), cholinergic urticaria (CHOL), and delayed pressure urticaria/angioedema (DPUA)...
October 2016: Current Opinion in Allergy and Clinical Immunology
Takaaki Hiragun, Michihiro Hide
For many years, sweat has been recognized as an exacerbation factor in all age groups of atopic dermatitis (AD) and a trigger of cholinergic urticaria (CholU). Recently, we reported the improvement of AD symptoms by spray with tannic acid, which suppresses basophil histamine release by semipurified sweat antigens in vitro, and showering that removes antigens in sweat from the skin surface. We finally identified MGL_1304 secreted by Malassezia globosa as a major histamine-releasing antigen in human sweat. MGL_1304 is detected as a 17-kDa protein in sweat and exhibits almost the highest histamine-release ability from basophils of patients with AD and CholU among antigens derived from Malassezia species...
2016: Current Problems in Dermatology
Yoshiki Tokura
Cholinergic urticaria (CholU) is characterized by pinpoint-sized, highly pruritic wheals occurring upon sweating. Both direct and indirect theories in the interaction of acetylcholine (ACh) with mast cells have been put forward in the sweating-associated histamine release from mast cells. In the mechanism of indirect involvement of ACh, patients are hypersensitive to sweat antigen(s) and develop wheals in response to sweat substances leaking from the syringeal ducts to the dermis, possibly by obstruction of the ducts...
2016: Current Problems in Dermatology
Takahiro Satoh
Acquired idiopathic generalized anhidrosis (AIGA) is a sweating disorder characterized by inadequate sweating in response to heat stimuli such as high temperature, humidity, and physical exercise. Patients exhibit widespread nonsegmental hypohidrosis/anhidrosis without any apparent cause, but the palms, soles, and axillae are rarely affected. Heat stroke readily develops due to increased body temperature. AIGA commonly affects young males. Approximately 30-60% of patients show complications of cholinergic urticaria, also known as idiopathic pure sudomotor failure or hypohidrotic cholinergic urticaria...
2016: Current Problems in Dermatology
Katja Koch, Karsten Weller, Andreas Werner, Marcus Maurer, Sabine Altrichter
No abstract text is available yet for this article.
June 29, 2016: Journal of Allergy and Clinical Immunology
S Altrichter, K Koch, M K Church, M Maurer
BACKGROUND: Cholinergic urticaria (CholU) is a frequent chronic urticaria disorder with itchy weal and flare-type skin reactions in response to physical exercise or passive warming. A higher frequency of atopy among CholU patients has been reported, but the significance of this observation is unclear. OBJECTIVE: To assess the prevalence and relevance of atopy in CholU patients. MATERIALS AND METHODS: Thirty CholU patients were assessed for atopic skin diathesis (atopic predisposition) by use of the Erlangen Atopy Score and divided into atopic and non-atopic predisposed CholU individuals...
December 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Hee Joo Kim, Min-Geol Lee
BACKGROUND: Cholinergic urticaria (ChU) is characterized by small wheals induced by an elevated core temperature. Its pathomechanism and various aspects of its clinical manifestations are still poorly understood. This study aimed to evaluate the spectrum of symptoms and signs of ChU in Korean patients. METHODS: We retrospectively reviewed the medical records of patients diagnosed with ChU. RESULTS: Among 203 patients (188 male and 15 female), 29 (14%) complained only of an itching or burning sensation without visible skin eruption...
May 13, 2016: Australasian Journal of Dermatology
Nicholas G Kounis, George N Kounis, George D Soufras
No abstract text is available yet for this article.
January 2016: Journal of Pharmacology & Pharmacotherapeutics
M Magerl, S Altrichter, E Borzova, A Giménez-Arnau, C E H Grattan, F Lawlor, P Mathelier-Fusade, R Y Meshkova, T Zuberbier, M Metz, M Maurer
These recommendations for the definition, diagnosis and management of chronic inducible urticaria (CIndU) extend, revise and update our previous consensus report on physical urticarias and cholinergic urticaria (Allergy, 2009). The aim of these recommendations is to improve the diagnosis and management of patients with CIndU. Our recommendations acknowledge the latest changes in our understanding of CIndU, and the available therapeutic options, as well as the development of novel diagnostic tools.
June 2016: Allergy
E Pezzolo, A Peroni, P Gisondi, G Girolomoni
Heat urticaria (HU) is a rare type of physical inducible urticaria, characterized by itchy erythema and well-demarcated weals appearing soon after heat exposure. Most cases occur in female patients aged 20-45 years. Both localized and generalized forms exist, depending on the limitation of the reaction to the skin area directly exposed to the physical stimulus or the involvement of distant sites, respectively. In most cases, HU is an immediate reaction, but delayed forms (mostly familial) have been described...
September 2016: British Journal of Dermatology
Yasmin Moolani, Charles Lynde, Gordon Sussman
There have been recent advances in the classification and management of chronic urticaria. The new term chronic spontaneous urticaria (CSU) has replaced chronic idiopathic urticaria and chronic autoimmune urticaria. In addition, chronic inducible urticaria (CINDU) has replaced physical urticaria and includes other forms of inducible urticaria, such as cholinergic and aquagenic urticaria. Furthermore, novel research has resulted in a new understanding with guidelines being revised in the past year by both the American Academy of Allergy, Asthma, and Immunology (AAAAI) and the European Academy of Allergy and Clinical Immunology (EAACI)/Global Allergy and Asthma European Network (GA (2)LEN)/European Dermatology Forum (EDF)/World Allergy Organization (WAO)...
2016: F1000Research
Peter Vadas, Angela Sinilaite, Marcus Chaim
BACKGROUND: Cholinergic urticaria is a form of physical urticaria triggered by high ambient temperature, strenuous physical activity, and strong emotion. These same triggers may cause multisystem reactions that can be life-threatening. A study of patients with cholinergic urticaria with anaphylaxis was undertaken to describe the demographic and clinical features of this form of anaphylaxis. OBJECTIVE: To describe a cohort of patients with anaphylaxis triggered by high ambient temperature, exertion, and stress...
March 2016: Journal of Allergy and Clinical Immunology in Practice
Kaori Ishii, Makiko Hiragun, Takaaki Hiragun, Takanobu Kan, Tomoko Kawaguchi, Yuhki Yanase, Akio Tanaka, Shunsuke Takahagi, Michihiro Hide
MGL_1304, a major allergen in human sweat for patients with atopic dermatitis and/or cholinergic urticaria, is secreted from Malassezia globosa on human skin. The amounts of MGL_1304 and IgE against MGL_1304 are evaluated by the histamine release test using basophils or mast cells sensitized with serum containing IgE against MGL_1304, and enzyme linked sorbent assay (ELISA) using MGL_1304 and anti-MGL_1304 antibodies. Here, we identified a human monoclonal IgE (ABS-IgE) that binds to the high affinity IgE receptor (FcεRI) and MGL_1304 with high affinity (KD = 1...
December 4, 2015: Biochemical and Biophysical Research Communications
M Honma, S Iinuma, K Kanno, S Komatsu, M Minami-Hori, H Iizuka, A Ishida-Yamamoto
BACKGROUND: Hypohidrosis/anhidrosis are congenital or acquired sweating impairments. Among them, acquired idiopathic generalized anhidrosis/hypohidrosis (AIGA) is the most common, and characterized by favourable response to systemic corticosteroid, however, no clinical markers for disease severity or activity have been developed. OBJECTIVE: Our aim was to verify the usefulness of serum carcinoembryonic antigen (CEA) level monitoring as a clinical marker for disease activity of AIGA...
August 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Sapna Gajbhiye, Rajendra Prasad Agrawal, Shubham Atal, Vikalp Tiwari, Pradeep Phadnis
We report a rare case of exercise-induced anaphylaxis (EIA), occurring exclusively with exercise, without any other associated trigger, detected in the prodromal phase, and prevented from additional anaphylaxis episodes by treatment with cetirizine and 10 mg daily of antileukotriene montelukast to date. EIA is a syndrome in which patients experience a spectrum of the symptoms of anaphylaxis ranging from mild cutaneous signs to severe systemic manifestations such as hypotension, syncope, and even death after increased physical activity...
July 2015: Journal of Pharmacology & Pharmacotherapeutics
Takanobu Kan, Takaaki Hiragun, Kaori Ishii, Makiko Hiragun, Yuhki Yanase, Akio Tanaka, Michihiro Hide
BACKGROUND: We previously identified MGL_1304 secreted by Malassezia globosa as a sweat antigen for patients with atopic dermatitis (AD) and cholinergic urticaria (ChU). However, purifying native MGL_1304 from human sweat or culture supernatant of M. globosa (sup-MGL_1304) is costly and time-consuming. Moreover, recombinant MGL_1304 expressed by using Escherichia coli (TF-rMGL_1304) needs a large chaperon protein and lacks the original glycosylation of yeasts. Thus, we generated a recombinant MGL_1304 by Pichia pastoris (P-rMGL_1304) and investigated its characteristic features...
July 2015: Allergology International: Official Journal of the Japanese Society of Allergology
Jordan Trevisonno, Bhairavi Balram, Elena Netchiporouk, Moshe Ben-Shoshan
BACKGROUND: Physical urticaria (PU) is a subset of chronic urticaria (CU) induced by physical stimuli. To date, there is no consensus in the literature on the prevalence of PU among patients with CU. OBJECTIVES: Our objective was to review the clinical presentation, diagnosis and management of PU and to estimate the prevalence of PU in CU patients. METHODS: We performed a narrative review of PU and conducted a systemic review and meta-analysis to determine the pooled estimates of the prevalence of PU among patients with CU in the literature up to September 2014...
August 2015: Postgraduate Medicine
Kent S Handfield, Christopher K Dolan, Michael Kaplan
Cholinergic urticaria (CU) is triggered by a rise in body temperature and can be complicated by bronchial hyperresponsiveness and anaphylaxis. It primarily affects young adults who actively engage in strenuous exercise, such as servicemen and servicewomen. If the patient reports a history of wheezing or difficulty breathing with urticaria, a water challenge test in a warm bath can be performed to confirm the presence of anaphylaxis. The test should be conducted in an environment in which the patient's airway can be secured and epinephrine can be administered if necessary...
April 2015: Cutis; Cutaneous Medicine for the Practitioner
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