Paari Dominic, Javaria Ahmad, Hajra Awwab, Md Shenuarin Bhuiyan, Christopher G Kevil, Nicholas E Goeders, Kevin S Murnane, James C Patterson, Kristin E Sandau, Rakesh Gopinathannair, Brian Olshansky
Nonmedical use of prescription and nonprescription drugs is a worldwide epidemic, rapidly growing in magnitude with deaths because of overdose and chronic use. A vast majority of these drugs are stimulants that have various effects on the cardiovascular system including the cardiac rhythm. Drugs, like cocaine and methamphetamine, have measured effects on the conduction system and through several direct and indirect pathways, utilizing multiple second messenger systems, change the structural and electrical substrate of the heart, thereby promoting cardiac dysrhythmias...
January 2022: Circulation. Arrhythmia and Electrophysiology