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Renal graft MRI

Katja Hueper, Marcel Gutberlet, Jan Hinrich Bräsen, Mi-Sun Jang, Anja Thorenz, Rongjun Chen, Barbara Hertel, Amelie Barrmeyer, Martina Schmidbauer, Martin Meier, Sibylle von Vietinghoff, Abedalrazag Khalifa, Dagmar Hartung, Hermann Haller, Frank Wacker, Song Rong, Faikah Gueler
BACKGROUND: Kidney transplantation (ktx) in mice is used to learn about rejection and to develop new treatment strategies. Past studies have mainly been based on histological or molecular biological methods. Imaging techniques to monitor allograft pathology have rarely been used. METHODS: Here we investigated mice after isogenic and allogenic ktx over time with functional MRI with diffusion-weighted imaging (DWI) and mapping of T2-relaxation time (T2-mapping) to assess graft inflammation and edema formation...
2016: PloS One
J Sun, Z Y Xing, S N Yu, J Chen, T T Zha, M Fan, J H Ma, W Xing
OBJECTIVE: To explore the correlation between susceptibility weighted imaging (SWI) manifestation and serum cystatin C level for delayed graft function (DGF). METHODS: The conventional MRI, SWI and serum cystatin C of 27 cases with DGF in nephrotransplantation center in Third Affiliated Hospital of Suzhou University from September 2014 and August 2015 were retrospectively analyzed.By contrasting conventional MRI images of transplanted kidney in DGF, the imaging manifestations of benign tumors such as cysts and angiomyolipomas were excluded on SWI images, and then making the renal cortex as the reference, if the abnormal signal lesions were found in the transplanted kidney, the location and signal intensity would be analyzed...
June 7, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Katja Hueper, Abedalrazag A Khalifa, Jan H Bräsen, Van Dai Vo Chieu, Marcel Gutberlet, Sabine Wintterle, Frank Lehner, Nicolas Richter, Matti Peperhove, Susanne Tewes, Kristina Weber, Hermann Haller, Frank Wacker, Wilfried Gwinner, Faikah Gueler, Dagmar Hartung
PURPOSE: To combine diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) for detection of allograft dysfunction in patients early after kidney transplantation and to correlate diffusion parameters with renal function and renal histology of allograft biopsies. MATERIALS AND METHODS: Between day 4 and 11 after kidney transplantation 33 patients with initial graft function and 31 patients with delayed graft function (DGF) were examined with a 1.5T magnetic resonance imaging (MRI) scanner...
July 2016: Journal of Magnetic Resonance Imaging: JMRI
Yu-Ting Wang, Ying-Chun Li, Long-Lin Yin, Hong Pu, Jia-Yuan Chen
Kidney transplantation has emerged as the treatment of choice for many patients with end-stage renal disease, which is a significant cause of morbidity and mortality. Given the shortage of clinically available donor kidneys and the significant incidence of allograft dysfunction, a noninvasive and accurate assessment of the allograft renal function is critical for postoperative management. Prompt diagnosis of graft dysfunction facilitates clinical intervention of kidneys with salvageable function. New advances in magnetic resonance imaging (MRI) technology have enabled the calculation of various renal parameters that were previously not feasible to measure noninvasively...
October 28, 2015: World Journal of Radiology
Jacob A Akoh
Autosomal dominant polycystic kidney disease (ADPKD), the most frequent cause of genetic renal disease affecting approximately 4 to 7 million individuals worldwide and accounting for 7%-15% of patients on renal replacement therapy, is a systemic disorder mainly involving the kidney but cysts can also occur in other organs such as the liver, pancreas, arachnoid membrane and seminal vesicles. Though computed tomography and magnetic resonance imaging (MRI) were similar in evaluating 81% of cystic lesions of the kidney, MRI may depict septa, wall thickening or enhancement leading to upgrade in cyst classification that can affect management...
September 6, 2015: World Journal of Nephrology
Katja Hueper, Bennet Hensen, Marcel Gutberlet, Rongjun Chen, Dagmar Hartung, Amelie Barrmeyer, Martin Meier, Wang Li, Mi-Sun Jang, Michael Mengel, Frank Wacker, Song Rong, Faikah Gueler
OBJECTIVES: The aims of this experimental study were to investigate renal allograft pathophysiology by multiparametric functional magnetic resonance imaging (MRI) and to directly correlate MRI parameters with renal histopathology in mouse models of allogenic and isogenic kidney transplantation (ktx). MATERIALS AND METHODS: Allograft rejection was induced by transplantation of C57BL/6 (B6) donor kidneys into BALB/c recipients (allogenic ktx). B6 mice that received B6 kidneys served as controls (isogenic ktx)...
January 2016: Investigative Radiology
Hoylan T Fernandez, Peter T W Kim, Tiffany L Anthony, Baron L Hamman, Robert M Goldstein, Giuliano Testa
The inferior vena cava (IVC) is the most common site of leiomyosarcomas arising from a vascular origin. Leiomyosarcomas of the IVC are categorized by anatomical location. Zone I refers to the infrarenal portion of the IVC, Zone II from the hepatic veins to the renal veins, and Zone III from the right atrium to the hepatic veins. This is a rare presentation of a Zone I-III leiomyosarcoma. Fifty-two-years-old female with a medical history significant only for HTN was admitted to the hospital with bilateral lower extremity edema and dyspnea...
October 2015: Journal of Surgical Oncology
Katja Hueper, Faikah Gueler, Jan Hinrich Bräsen, Marcel Gutberlet, Mi-Sun Jang, Frank Lehner, Nicolas Richter, Nils Hanke, Matti Peperhove, Petros Martirosian, Susanne Tewes, Van Dai Vo Chieu, Anika Großhennig, Hermann Haller, Frank Wacker, Wilfried Gwinner, Dagmar Hartung
Delayed graft function (DGF) after kidney transplantation is not uncommon, and it is associated with long-term allograft impairment. Our aim was to compare renal perfusion changes measured with noninvasive functional MRI in patients early after kidney transplantation to renal function and allograft histology in biopsy samples. Forty-six patients underwent MRI 4-11 days after transplantation. Contrast-free MRI renal perfusion images were acquired using an arterial spin labeling technique. Renal function was assessed by estimated glomerular filtration rate (eGFR), and renal biopsies were performed when indicated within 5 days of MRI...
June 15, 2015: American Journal of Physiology. Renal Physiology
Ping Wang, Christian Schuetz, Prashanth Vallabhajosyula, Zdravka Medarova, Aseda Tena, Lingling Wei, Kazuhiko Yamada, Shaoping Deng, James F Markmann, David H Sachs, Anna Moore
BACKGROUND: Information regarding the longevity of transplanted pancreatic islet grafts could provide valuable information for treatment options. In our previous studies, we showed that isolated autologous pancreatic islets could be labeled with iron oxide nanoparticles and monitored after transplantation using MRI. Here, we report on in vivo monitoring of a secondary damage that occurs at the later stages because of allogeneic immune rejection. METHODS: In the proof-of-principle studies, iron oxide-labeled autologous pancreatic islets were transplanted under the renal capsules of nonhuman primates...
August 2015: Transplantation
Parag P Tolat, W Dennis Foley, Christopher Johnson, Mark D Hohenwalter, Francisco A Quiroz
Pancreas transplantation aims to restore physiologic normoglycemia in diabetic patients with glomerulopathy and avoid or delay the onset of diabetic retinopathy and arteriopathy. Simultaneous pancreas-kidney transplant is the most common approach, using a cadaveric pancreas donation in conjunction with either cadaveric or live donor renal transplant. Alternative techniques include pancreas after kidney transplant, in which the pancreas transplant is performed some years after renal transplant. Pancreas transplant alone is utilized rarely in diabetic patients with compensated renal function...
April 2015: Radiology
Rajan K Patel, Christopher Pennington, Kathryn K Stevens, Alison Taylor, Keith Gillis, Elaine Rutherford, Nicola Johnston, Alan G Jardine, Patrick B Mark
BACKGROUND: Premature cardiovascular (CV) death is the commonest cause of death in renal transplant recipients. Abnormalities of left ventricular (LV) structure (collectively termed uremic cardiomyopathy) and left atrial (LA) dilation, a marker of fluid status and diastolic function, are risk factors for reduced survival in patients with end stage renal disease (ESRD). In the present analysis, we studied the impact of pre-transplant LA and LV abnormalities on survival after successful renal transplantation (RT)...
2014: Transplantation Research
Mohammad Ali Amirzargar, Ali Akbar Ilati, Amir Drakhshanfar, Jalal Poorolajal, Adel Eslami
In this report, we explain a case of true aneurysm of the internal iliac artery in a previously transplanted kidney, which was reconstructed successfully by interposing saphenous vein graft, using double balloon shunt to prevent renal ischemia as a new approach. The case was a 26 year old female with a 4 × 4 cm aneurysm at the anastomotic site of the transplanted renal artery detected by ultrasonographic evaluation and confirmed by magnetic resonance imaging technique. This rare complication was managed successfully through an open surgical arterial reconstruction using reversed saphenous vein graft...
December 2014: Archives of Iranian Medicine
Sung Yoon Park, Chan Kyo Kim, Byung Kwan Park, Sung Ju Kim, Sanghoon Lee, Wooseong Huh
PURPOSE: To investigate blood oxygenation level-dependent (BOLD) MRI and diffusion-weighted imaging (DWI) at 3 T for assessment of early renal allograft dysfunction. MATERIALS AND METHODS: 34 patients with a renal allograft (early dysfunction, 24; normal, 10) were prospectively enrolled. BOLD MRI and DWI were performed at 3 T. R2* and apparent diffusion coefficient (ADC) values were measured in cortex and medulla of the allografts. Correlation between R2* or ADC values and estimated glomerular filtration rate (eGFR) was investigated...
December 2014: European Journal of Radiology
Mary Hunt Martin, Jeffrey A Feinstein, Frandics P Chan, Alison L Marsden, Weiguang Yang, V Mohan Reddy
OBJECTIVES: To demonstrate the technical feasibility and describe intermediate outcomes for the initial patients undergoing handcrafted, area-preserving, Y-graft modification of the Fontan procedure. METHODS: A retrospective review of a pilot study was undertaken to describe preoperative, intraoperative, and postoperative results. RESULTS: Six patients underwent successful procedures and remain alive 3 to 4 years later. The median age at operation was 3...
January 2015: Journal of Thoracic and Cardiovascular Surgery
Anupma Kaul, Raj Kumar Sharma, Rakesh Kumar Gupta, Hira Lal, Abhishek Yadav, Dharmendra Bhadhuria, Narayan Prasad, Amit Gupta
Developing a non-invasive method such as diffusion-weighted magnetic resonance imaging (DWMRI) could be used as a feasible and reproducible modality in the differential diagnosis of allograft dysfunction. We assessed the functional status of the renal allograft by DWMRI and its applicability in assessment of graft dysfunction on all end-stage renal transplant patients who attained normal renal function on the 7th day post-transplantation. Follow-up imaging of the recipient allograft was performed at the end of 90 and 180 days and in case of graft dysfunction...
November 2014: Saudi Journal of Kidney Diseases and Transplantation
Aasim Afzal, Jamil Alsahhar, Adam Mora
Cancer Student/Resident Case Report Posters IIISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Primary sarcomas of the great vessels are rare. Presented is a case of an undifferentiated intimal sarcoma of the inferior vena cava (IVC) with extension to the right atrium, adrenal, and renal veins.CASE PRESENTATION: A 52-year-old woman presented with a one month history of fatigue, dyspnea and bilateral lower extremity edema. She was not in distress and hemodynamically stable...
October 1, 2014: Chest
Guangyi Liu, Fei Han, Wenbo Xiao, Qidong Wang, Ying Xu, Jianghua Chen
BACKGROUND: Acute rejection (AR) and acute tubular necrosis (ATN) are main causes of early renal allograft dysfunction. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) and Diffusion weighted (DW) MRI can provide valuable information about changes of oxygen bioavailability and water diffusion by measuring R2* or apparent diffusion coefficient (ADC) respectively. We aimed to determine the value of BOLD MRI and DW MRI in detecting causes for early allograft dysfunction in renal allograft recipients...
2014: BMC Nephrology
Gil Bolotin, Christoph Hans Huber, Liran Shani, Friedrich Wilhelm Mohr, Thierry P Carrel, Michael Andrew Borger, Volkmar Falk, David Taggart, Rony-Reuven Nir, Lars Englberger, Joerg Seeburger, Etem Caliskan, Christoph Thomas Starck
BACKGROUND: Stroke is a major cause of morbidity and mortality during open-heart surgery. Up to 60% of intraoperative cerebral events are emboli induced. This randomized, controlled, multicenter trial is the first human study evaluating the safety and efficacy of a novel aortic cannula producing simultaneous forward flow and backward suction for extracting solid and gaseous emboli from the ascending aorta and aortic arch upon their intraoperative release. METHODS: Sixty-six patients (25 females; 68±10 years) undergoing elective aortic valve replacement surgery, with or without coronary artery bypass graft surgery, were randomized to the use of the CardioGard (CardioGard Medical, Or-Yehuda, Israel) Emboli Protection cannula ("treatment") or a standard ("control") aortic cannula...
November 2014: Annals of Thoracic Surgery
Maria do Carmo B Teixeira, Madileine F Américo, Ricardo B Oliveira, José Ricardo A Miranda, Fernando G Romeiro, Luciana A Corá
BACKGROUND: Immunosuppressive therapy after kidney transplant is necessary to prevent allograft rejection and it is the cause of several gastrointestinal (GI) disorders that have been scantily studied. OBJECTIVES: This study was aimed at investigating the influence of triple immunosuppressive therapy on GI transit in renal transplant patients by employing a biomagnetic technique. METHODS: Twenty-one renal transplant patients underwent triple therapy, which included either tacrolimus (TAC) or cyclosporin A (CsA) associated with prednisone and azathioprine...
January 2015: Digestive Diseases and Sciences
Song Rong, Katja Hueper, Torsten Kirsch, Robert Greite, Christian Klemann, Michael Mengel, Matthias Meier, Jan Menne, Michael Leitges, Nathan Susnik, Martin Meier, Hermann Haller, Nelli Shushakova, Faikah Gueler
Acute kidney injury (AKI) increases the risk of morbidity and mortality after major surgery and transplantation. We investigated the effect of PKC-ε deficiency on AKI and ischemic allograft damage after kidney transplantation. PKC-ε-deficient and wild type (WT) control mice were subjected to 35 min of renal pedicle clamping to induce AKI. PKC-ε deficiency was associated with a marked improvement in survival and an attenuated loss of kidney function. Furthermore, functional MRI experiments revealed better renal perfusion in PKC-ε-deficient mice than in WT mice one day after IRI...
September 15, 2014: American Journal of Physiology. Renal Physiology
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