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https://www.readbyqxmd.com/read/29670041/comparative-evaluation-of-arabin-pessary-and-cervical-cerclage-for-the-prevention-of-preterm-labor-in-asymptomatic-women-with-high-risk-factors
#1
Panagiotis Tsikouras, George Anastasopoulos, Vasileios Maroulis, Anastasia Bothou, Anna Chalkidou, Dorelia Deuteraiou, Xanthoula Anthoulaki, Georgios Tsatsaris, Arzou Halil Bourazan, George Iatrakis, Stefanos Zervoudis, Georgios Galazios, Lola-Katerina Inagamova, Roland Csorba, Alexander-Tobias Teichmann
OBJECTIVE: Preterm labor is one of the most significant obstetric problems associated with high rate of actual and long-term perinatal complications. Despite the creation of scoring systems, uterine activity monitoring, cervical ultrasound and several biochemical markers, the prediction and prevention of preterm labor is still a matter of concern. The aim of this study was to examine cervical findings for the prediction and the comparative use of Arabin pessary or cerclage for the prevention of preterm birth in asymptomatic women with high risk factors for preterm labor...
April 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29561415/successful-use-of-pessary-for-uterine-prolapse-after-pelvic-trauma-in-a-nulliparous-young-female-a-case-report
#2
Fang-Fang Ai, Meng Mao, Ye Zhang, Jia Kang, Lan Zhu
RATIONALE: To date, sporadic studies have shown that a relationship exists between delayed pelvic organ prolapse (POP) and pelvic trauma, and these cases have all been managed with surgical procedures. PATIENT CONCERNS: A 29-year-old, nulliparous (Gravida 0) woman without sexual experience was referred to our gynecology outpatient clinic, complaining of a protruding vaginal mass 5 years after a traffic accident (hit by a truck when she was walking) that caused serious multiple injuries...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29539932/re-natural-history-of-pessary-use-in-women-aged-65-74-versus-75-years-and-older-with-pelvic-organ-prolapse-a-12-year-study
#3
Tomas L Griebling
No abstract text is available yet for this article.
May 2017: Journal of Urology
https://www.readbyqxmd.com/read/29502352/surgery-for-women-with-posterior-compartment-prolapse
#4
REVIEW
Alex Mowat, Declan Maher, Kaven Baessler, Corina Christmann-Schmid, Nir Haya, Christopher Maher
BACKGROUND: Posterior vaginal wall prolapse (also known as 'posterior compartment prolapse') can cause a sensation of bulge in the vagina along with symptoms of obstructed defecation and sexual dysfunction. Interventions for prevention and conservative management include lifestyle measures, pelvic floor muscle training, and pessary use. We conducted this review to assess the surgical management of posterior vaginal wall prolapse. OBJECTIVES: To evaluate the safety and effectiveness of any surgical intervention compared with another surgical intervention for management of posterior vaginal wall prolapse...
March 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29495355/semi-solid-and-solid-dosage-forms-for-the-delivery-of-phage-therapy-to-epithelia
#5
REVIEW
Teagan L Brown, Steve Petrovski, Hiu Tat Chan, Michael J Angove, Joseph Tucci
The delivery of phages to epithelial surfaces for therapeutic outcomes is a realistic proposal, and indeed one which is being currently tested in clinical trials. This paper reviews some of the known research on formulation of phages into semi-solid dosage forms such as creams, ointments and pastes, as well as solid dosage forms such as troches (or lozenges and pastilles) and suppositories/pessaries, for delivery to the epithelia. The efficacy and stability of these phage formulations is discussed, with a focus on selection of optimal semi-solid bases for phage delivery...
February 26, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29478114/effectiveness-of-a-continuous-use-ring-shaped-vaginal-pessary-without-support-for-advanced-pelvic-organ-prolapse-in-postmenopausal-women
#6
José Luis Dueñas, Alessio Miceli
INTRODUCTION AND HYPOTHESIS: There is considerable variation in the clinical management of pessaries. This study was aimed at exploring the efficacy of the continuous use of ring pessaries without support for the treatment of advanced pelvic organ prolapse (POP) in nonhysterectomized postmenopausal women. METHODS: We conducted this prospective study of fitted pessaries between January 2013 and June 2015 in the Department of Obstetrics and Gynecology at Macarena Hospital, Seville University, Spain...
February 24, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29478112/effect-of-generalized-anxiety-disorders-on-the-success-of-pessary-treatment-for-pelvic-organ-prolapse
#7
Fang-Fang Ai, Meng Mao, Ye Zhang, Jia Kang, Lan Zhu
INTRODUCTION AND HYPOTHESIS: Our aim was to evaluate the impact of generalized anxiety disorders (GAD) on the effectiveness of pessary treatment for pelvic organ prolapse (POP) in postmenopausal women. METHODS: One-hundred and ten women with symptomatic POP who underwent pessary treatment were enrolled in this prospective study. Subjective evaluations of pelvic floor symptoms were assessed using the Pelvic Floor Distress Inventory (PFDI-20) and the Pelvic Floor Impact Questionnaire-7 (PFIQ-7), both at baseline and at the 3-month follow-up visit after pessary use...
February 24, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29474292/changes-in-the-vaginal-microenvironment-as-related-to-frequency-of-pessary-removal
#8
Nicole J Fregosi, Deslyn T G Hobson, Casey L Kinman, Jeremy T Gaskins, J Ryan Stewart, Kate V Meriwether
OBJECTIVE: The aim of the study was to describe the effect of frequency of pessary removal on the vaginal microenvironment. METHODS: We performed a secondary analysis of a multicenter randomized trial of hydroxyquinoline gel in women presenting for pessary fitting. Patients had vaginal secretions analyzed at baseline, 2 weeks, and 3 months. Patients were stratified by frequency of pessary removal at least once daily, at least once weekly, and less often than once weekly...
March 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29468770/pessary-for-prevention-of-preterm-birth-in-twin-pregnancy-with-short-cervix-3-year-follow-up-study
#9
J van 't Hooft, J H van der Lee, B C Opmeer, A G van Wassenaer-Leemhuis, A L van Baar, D J Bekedam, L J P Steenis, S Liem, E Schuit, C Cuijpers, E Bleeker, M E Vinke, N Simons, I M de Graaf, B W J Mol, C van de Beek
OBJECTIVE: A recent randomized clinical trial (ProTWIN) showed that a cervical pessary prevented preterm birth and improved neonatal outcome in women with multiple pregnancy and cervical length (CL) < 38 mm. In this follow-up study, the long-term developmental outcome of these children was evaluated at 3 years' corrected age. METHODS: This was a follow-up study of ProTWIN, a multicenter trial conducted between 2009 and 2012 in which asymptomatic women with a multiple pregnancy were randomized to placement of a cervical pessary or no intervention...
February 22, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29447856/laparoscopic-sacrohysteropexy-in-a-woman-at-12-weeks-gestation
#10
Berna Haliloglu Peker, Erdin Ilter, Hakan Peker, Aygen Celik, Ali Gursoy, Onur Gunaldi
STUDY OBJECTIVE: To demonstrate laparoscopic sacrohysteropexy for a case of uterine prolapse in a 12 weeks, 3 days pregnant woman. To our knowledge this is the first case of laparoscopic sacrohysteropexy performed at 12 weeks of gestation to be reported in literature. DESIGN: A step-by-step explanation of the surgical procedure (Canadian Task Force classification III). SETTING: Maltepe University Hospital. PATIENT: A 37-year-old pregnant woman...
February 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29442481/quality-of-life-in-women-with-advanced-pelvic-organ-prolapse-treated-with-gellhorn-pessary
#11
Stefania Palmieri, Alice Cola, Rodolfo Milani, Stefano Manodoro, Matteo Frigerio
No abstract text is available yet for this article.
February 13, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29425837/robotic-assisted-sacrocolpopexy-early-postoperative-outcomes-after-surgical-reduction-of-enlarged-genital-hiatus
#12
Megan S Bradley, Amy L Askew, Monique H Vaughan, Amie Kawasaki, Anthony G Visco
BACKGROUND: Currently, the decision to perform a concurrent posterior repair/perineoplasty at the time of robotic-assisted sacrocolpopexy is not standardized. OBJECTIVE: To compare anatomic failure after robotic-assisted sacrocolpopexy among three groups of patients categorized by their pre- and post-operative genital hiatus size. STUDY DESIGN: We performed a retrospective cohort study of women who underwent robotic-assisted sacrocolpopexy, from 1/2013 to 9/2016...
February 6, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29420400/customized-pessary-fabrication-using-three-dimensional-printing-technology
#13
Michael Barsky, Robert Kelley, Faiz Y Bhora, Anne Hardart
BACKGROUND: Pessaries are a treatment option for pelvic organ prolapse, stress urinary incontinence (SUI), and cervical incompetence. An effective pessary is comfortable, corrects the presenting problem, does not cause adverse effects, and is easy to remove. Discomfort and poor fit limit the usefulness of pessaries for many women. Each patient presents with unique anatomy and thus the effectiveness of commercially available pessaries may be limited by lack of customization. METHOD: A patient presenting with SUI and failed commercial pessary fittings desired nonsurgical treatment...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29408744/the-use-of-antenatal-fetal-magnetic-resonance-imaging-in-the-assessment-of-patients-at-high-risk-of-preterm-birth
#14
REVIEW
L Story, J Hutter, T Zhang, A H Shennan, M Rutherford
Preterm birth, defined as birth occurring prior to 37 weeks gestation is a common obstetric complication affecting 8% of pregnancies and is associated with significant morbidity and mortality. Infection/inflammation has been implicated in both the aetiology of preterm birth itself and associated neonatal pulmonary and neurological morbidity. Treatment options are currently limited to prolongation of the pregnancy using cervical cerclage, pessaries or progesterone or administration of drugs including steroids to promote lung maturity and neuroprotective agents such as magnesium sulphate, the timing of which are highly critical...
March 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29408268/the-development-of-progesterone-loaded-nanofibers-using-pressurized-gyration-a-novel-approach-to-vaginal-delivery-for-the-prevention-of-pre-term-birth
#15
Francis Brako, Bahijja Tolulope Raimi-Abraham, Suntharavathanan Mahalingam, Duncan Q M Craig, Mohan Edirisinghe
Recent evidence has continued to support the applicability of progesterone in preventing preterm birth, hence the development of an appropriate vaginal delivery system for this drug would be of considerable interest. Here, we describe the development of progesterone-loaded bioadhesive nanofibers using pressurized gyration for potential incorporation into a vaginal insert, with a particular view to addressing the challenges of incorporating a poorly water-soluble drug into a hydrophilic nanofiber carrier. Polyethylene oxide and carboxymethyl cellulose were chosen as polymers to develop the carrier systems, based on previous evidence of their yielding mucoadhesive nanofibers using the pressurized gyration technique...
February 2, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29397780/depressive-symptoms-affect-outcomes-of-pessary-use-in-postmenopausal-women-with-uterine-prolapse
#16
F-F Ai, L Zhu, M Mao, Y Zhang, J Kang
OBJECTIVE: This study aimed to investigate the impact of depressive symptoms on successful pessary treatment for postmenopausal women with symptomatic pelvic organ prolapse (POP). METHODS: We performed a prospective study involving postmenopausal women with POP who visited our clinic seeking pessary treatment. Demographic information and medical histories were collected. The participants completed the following questionnaires at baseline and after 3 months of successful pessary use: (1) the Pelvic Floor Impact Questionnaire-7 (PFIQ-7); (2) the Pelvic Floor Distress Inventory (PFDI-20); and (3) the Patient Health Questionnaire-9 (PHQ-9)...
February 3, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29358718/the-prevalence-and-treatment-pattern-of-clinically-diagnosed-pelvic-organ-prolapse-a-korean-national-health-insurance-database-based-cross-sectional-study-2009-2015
#17
Jin-Sung Yuk, Jung Hun Lee, Jun-Young Hur, Jung-Ho Shin
The study aim was to evaluate the prevalence of pelvic organ prolapse using claim data of South Korea and to evaluate treatment patterns. The Korea National Health Insurance Corporation pay medical costs for most diseases. This study used Health Insurance Review & Assessment Service-National Inpatient Sample (HIRA-NIS) 2009-2015. Pelvic organ prolapse was defined by diagnostic code (N81.x). Of the approximately 4.5 million women included in HIRA-NIS 2009-2015, 10,305 women were selected as having pelvic organ prolapse, and the mean age of the pelvic organ prolapse group was 63...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29290215/predictors-for-dislodgment-of-vaginal-pessary-within-one-year-in-women-with-pelvic-organ-prolapse
#18
Rachel Y K Cheung, Loreta L L Lee, Tony K H Chung, Symphorosa S C Chan
OBJECTIVES: To identify clinical risk factors for dislodgment of vaginal pessary within one year in women with symptomatic pelvic organ prolapse. STUDY DESIGN: This was a prospective observational study which recruited consecutive women with symptomatic pelvic organ prolapse in a tertiary urogynecology center. Basic demographics, clinical symptoms and staging of pelvic organ prolapse were assessed. A vaginal pessary was offered where appropriate. MAIN OUTCOME MEASURES: Demographics and clinical parameters were compared between women who were able to use a vaginal pessary for one year and those whose pessaries were dislodged within one year...
February 2018: Maturitas
https://www.readbyqxmd.com/read/29260618/progesterone-for-preventing-pregnancy-termination-after-initiation-of-medical-abortion-with-mifepristone
#19
Deborah Garratt, Joseph V Turner
INTRODUCTION: Abortion is often a difficult and traumatic decision for a woman to make. Perhaps greater distress occurs when a woman commences a medical abortion but then changes her mind and wishes to keep the now-threatened pregnancy. One published case series detailed a potential method to counter/reverse the abortifacient effect of mifepristone by administering parenteral progesterone in such situations. OBJECTIVES: The present report details cases of women in similar circumstances who have been treated with progesterone...
December 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29260226/effect-of-cervical-pessary-on-spontaneous-preterm-birth-in-women-with-singleton-pregnancies-and-short-cervical-length-a-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Gabriele Saccone, Giuseppe Maria Maruotti, Antonia Giudicepietro, Pasquale Martinelli
Importance: Spontaneous preterm birth is a major cause of perinatal morbidity and mortality. It is unclear if a cervical pessary can reduce the risk of spontaneous preterm delivery. Objective: To test whether in asymptomatic women with singleton pregnancies and no prior spontaneous preterm birth but with short cervical length on transvaginal ultrasound, use of a cervical pessary would reduce the rate of spontaneous preterm birth at less than 34 weeks of gestation...
December 19, 2017: JAMA: the Journal of the American Medical Association
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