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Nonalcoholic fatty liver

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https://www.readbyqxmd.com/read/29690903/ccl20-is-up-regulated-in-non-alcoholic-fatty-liver-disease-fibrosis-and-is-produced-by-hepatic-stellate-cells-in-response-to-fatty-acid-loading
#1
Xin Chu, Qunyan Jin, Hui Chen, G Craig Wood, Anthony Petrick, William Strodel, Jon Gabrielsen, Peter Benotti, Tooraj Mirshahi, David J Carey, Christopher D Still, Johanna K DiStefano, Glenn S Gerhard
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme obesity. Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors involved in the progression from simple steatosis to fibrosis remain poorly understood. METHODS: Gene expression profiling using microarray, PCR array, and RNA sequencing was performed on RNA from liver biopsy tissue from patients with extreme obesity...
April 24, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29688336/nonalcoholic-fatty-liver-disease-in-inflammatory-bowel-disease-prevalence-and-risk-factors
#2
Principi Mariabeatrice, Iannone Andrea, Losurdo Giuseppe, Mangia Michela, Shahini Endrit, Albano Francesca, Salvatore Fabio Rizzi, Rosa Federica La Fortezza, Lovero Rosa, Contaldo Antonella, Barone Michele, Leandro Gioacchino, Ierardi Enzo, Di Leo Alfredo
Background: Nonalcoholic fatty liver disease (NAFLD) is common in inflammatory bowel diseases (IBD). Herein, NAFLD prevalence and risk factors in a large IBD cohort were evaluated and compared to that of a non-IBD sample. Methods: Crohn's disease/ulcerative colitis outpatients referred to IBD service of our Gastroenterology Unit were enrolled. Subjects affected by functional and motor gastrointestinal disorders, in whom IBD was ruled out, referred to general outpatient service in the same area, were considered as nonIBD group...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29686469/evaluation-of-safety-for-hepatectomy-in-a-novel-mouse-model-with-nonalcoholic-steatohepatitis
#3
Yusuke Ozawa, Takafumi Tamura, Yohei Owada, Yoshio Shimizu, Akira Kemmochi, Katsuji Hisakura, Takashi Matsuzaka, Hitoshi Shimano, Hiroko Isoda, Nobuhiro Ohkohchi
AIM: To investigate whether the liver resection volume in a newly developed nonalcoholic steatohepatitis (NASH) model influences surgical outcome. METHODS: For establishment of a NASH model, mice were fed a high-fat diet for 4 wk, administered CCl4 for the last 2 wk, and administered T0901317 for the last 5 d. We divided these mice into two groups: A 30% partial hepatectomy (PH) of NASH liver group and a 70% PH of NASH liver group. In addition, a 70% PH of normal liver group served as the control...
April 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29686467/multiomics-biomarkers-for-the-prediction-of-nonalcoholic-fatty-liver-disease-severity
#4
REVIEW
Carlos J Pirola, Silvia Sookoian
This review intends to uncover how information from large-scale genetic profiling (whole genome sequencing, and whole exome sequencing) of nonalcoholic fatty liver disease (NAFLD), as well as information from circulating transcriptomics (cell-free miRNAs) and metabolomics, contributes to the understanding of NAFLD pathogenesis. A further aim is to address the question of whether OMICs information is ready to be implemented in the clinics. The available evidence suggests that any new knowledge pertaining to molecular signatures associated with NAFLD and nonalcoholic steatohepatitis should be promptly translated into the clinical setting...
April 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29685617/validation-of-transient-elastography-cut-points-to-assess-advanced-liver-fibrosis-in-children-and-young-adults-the-boston-children-s-hospital-experience
#5
Christine K Lee, Paul D Mitchell, Roshan Raza, Sarah Harney, Shanna M Wiggins, Maureen M Jonas
OBJECTIVE: To derive an optimal liver stiffness measurement cut point to discriminate METAVIR fibrosis stage F4 and to validate both METAVIR fibrosis stage F3-F4 and F4 cut points in a separate cohort. STUDY DESIGN: Patients at Boston Children's Hospital with liver stiffness measurement from 2006 to 2016 and liver biopsy ≤12 months before screening were eligible. Patients enrolled 2006-2011 were used to calibrate liver stiffness measurement cut points and those enrolled 2011-2016 for validation...
April 20, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29683981/chronic-liver-diseases-and-the-potential-use-of-s-adenosyl-l-methionine-as-a-hepatoprotector
#6
Silvia I Mora, Jonathan García-Román, Iván Gómez-Ñañez, Rebeca García-Román
Chronic liver diseases result in overall deterioration of health status and changes in metabolism. The search for strategies to control and combat these hepatic diseases has witnessed a great boom in the last decades. Nutritional therapy for controlling and managing liver diseases may be a positive influence as it improves the function of the liver. In this review, we focus mainly on describing liver conditions such as nonalcoholic fatty liver disease, and intrahepatic cholestasis as well as using S-adenosyl-L-methionine as a dietary supplement and its potential alternative therapeutic effect to correct the hepatic dysfunction associated with these conditions...
April 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29683979/lifestyle-interventions-for-patients-with-nonalcoholic-fatty-liver-disease-a-network-meta-analysis
#7
Tian-Tian Zou, Chao Zhang, Yi-Fan Zhou, Yi-Jing Han, Jiao-Jiao Xiong, Xi-Xi Wu, Yong-Ping Chen, Ming-Hua Zheng
Lifestyle interventions remain the first-line therapy for nonalcoholic fatty liver disease (NAFLD). This study aims to evaluate the individual impact of exercise and/or dietary interventions on the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), homeostasis model of assessment for insulin resistance index (HOMA-IR), and BMI. Randomized-controlled trials from patients diagnosed with NAFLD were included in the meta-analysis if they reported the associations between changes in ALT, AST, HOMA-IR, or BMI and types of lifestyle interventions...
April 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29682868/role-and-mechanisms-of-autophagy-in-acetaminophen-induced-liver-injury
#8
Xiaojuan Chao, Hua Wang, Hartmut Jaeschke, Wen-Xing Ding
Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in the United States and many other countries. Although the metabolism and pathogenesis of APAP has been extensively investigated for decades, the mechanisms by which APAP induces liver injury are incompletely known, which hampers the development of effective therapeutic approaches to tackle this important clinical problem. Autophagy is a highly conserved intracellular degradation pathway, which aims at recycling cellular components and damaged organelles in response to adverse environmental conditions and stresses as a survival mechanism...
April 23, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29682494/cognitive-changes-and-brain-volume-reduction-in-patients-with-nonalcoholic-fatty-liver-disease
#9
Branka Filipović, Olivera Marković, Vesna Đurić, Branislav Filipović
Studies of psychological condition of patients suffering from nonalcoholic fatty liver disease are rather equivocal about the results: while some claim that NAFLD patients suffer from anxiety and depression more than non-NAFLD controls, others do not withstand those findings. Lower cognitive potentials have also been reported, both in patient related and in animal model-based investigations, and correlated with assessed brain tissue changes. We hypothesized that NAFLD, as a condition, affects the brain tissue and, subsequently, the cognitive state...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29679552/serum-retinol-binding-protein-4-and-galectin-3-binding-protein-as-novel-markers-for-postmenopausal-nonalcoholic-fatty-liver-disease
#10
Hong Cai, Sha Lu, Yueming Chen, Sayantana Das, Zheng Niu, Guangchao Zhuo, Lei Lai, Zhifen Zhang
OBJECTIVE: To investigate the differential protein expression before and after menopause in women with nonalcoholic fatty liver disease (NAFLD) and to explore novel markers for menopausal NAFLD. METHODS: Eight serum samples collected from pre- or post-menopausal women with NAFLD were analysed by iTRAQ 2D-LC-MS/MS. Two protein candidates were selected and verified by enzyme-linked immunosorbent assay (ELISA) in serum samples collected from a one hundred and fifty-three female population subsequently, including 51 in post-menopausal status with NAFLD, 41 in pre-menopausal with NAFLD, 19 healthy individuals in post-menopausal status and 42 healthy pre-menopausal women...
April 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29679298/future-of-treatment-for-nonalcoholic-steatohepatitis-can-the-use-of-safe-evidence-based-clinically-proven-supplements-provide-the-answer-to-the-unmet-need
#11
REVIEW
Yaron Ilan
The epidemic of nonalcoholic fatty liver disease (NAFLD) has created a real and unmet therapeutic need. The long regulatory pathway and the focus on selected subsets of patients with established and advanced disease are some of the current obstacles to providing effective treatment for the majority of NAFLD patients. The complexity of the disease pathogenesis, which involves multiple mechanisms, requires targeting of more than one pathway or a combination-based therapy. Although the drugs being developed may prevent progression to cirrhosis or may decrease negative liver outcomes, their effects on cardiometabolic health and cancer prevention remain unknown...
April 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29678641/liver-directed-microrna-7a-depletion-induces-nonalcoholic-fatty-liver-disease-by-stabilizing-yy1-mediated-lipogenic-pathways-in-zebrafish
#12
Chi-Yu Lai, Chiu-Ya Lin, Chia-Chun Hsu, Kun-Yun Yeh, Guor Mour Her
Nonalcoholic fatty liver disease (NAFLD) has been associated with the function and changes in expression levels of microRNAs (miRs). MiR-7 has been proven to play an important role in many cellular processes; however, its functions in the context of liver lipogenesis remain unknown. We applied the microRNA-sponge (miR-SP) technology and generated transgenic miR-7a-SP models (hC7aSP and bC7aSP), which disrupted the activities of hepatic miR-7a and induced the early onset of NAFLD and nonalcoholic steatohepatitis (NASH) in zebrafish...
April 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29675053/the-potential-effect-of-chinese-herbal-formula-hongqijiangzhi-fang-in-improving-nafld-focusing-on-nlrp3-inflammasome-and-gut-microbiota
#13
Shu Liang, Yupei Zhang, Yuanjun Deng, Yifang He, Yinji Liang, Zien Liang, Yanning Chen, Kairui Tang, Runsen Chen, Qinhe Yang
The present study investigates the potential therapeutic mechanism underlying the effects of the Chinese herbal formula Hongqijiangzhi Fang (HJF) on nonalcoholic fatty liver disease (NAFLD) in rats. Male Sprague Dawley (SD) rats were randomly divided into 4 groups ( n = 8): control group was fed a normal diet, three other groups were fed high-fat diets (HFD), and the two treatment groups were intragastrically given a compound probiotic or HJF during the molding time. After 16 w, related indices were detected...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29673615/the-influence-of-abdominal-and-ectopic-fat-accumulation-on-carotid-intima-media-thickness-a-chongqing-study
#14
Xu Yi, Yu-Hui Liu, Xin-Fu Zhou, Yan-Jiang Wang, Juan Deng, Juan Liu, Hong-Bo He, Zhi-Qiang Xu
BACKGROUND: To investigate the effects of abdominal obesity (AO) and nonalcoholic fatty liver disease (NAFLD) with or without AO on carotid arteries by determining carotid intima-media thickness (CIMT). METHODS: A total of 2745 Chinese Han adults (aged between 40 and 50 years old) were recruited and divided into 4 groups: (1) NW-no NAFL group: the normal body weight without NAFLD (n = 1888); (2) AO-no NAFL group: AO without NAFLD (n = 259); (3) NW-with NAFL group: NAFLD without AO (n = 93); and (4) AO-with NAFL group: AO with NAFLD (n = 505)...
April 16, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29673321/relationship-of-sarcopenia-with-steatohepatitis-and-advanced-liver-fibrosis-in-non-alcoholic-fatty-liver-disease-a-meta-analysis
#15
Rui Yu, Qiangwei Shi, Lei Liu, Lidong Chen
BACKGROUND: Several studies have emerged indicating that sarcopenia is associated with nonalcoholic fatty liver disease, we aimed to systematically review and quantify the association between sacropenia and the histological severity of nonalcoholic fatty liver disease. METHODS: Pubmed, the Cochrane Library and EMBASE were searched (until August 2017) for studies examining the relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in nonalcoholic fatty liver disease...
April 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29672963/butein-protects-the-nonalcoholic-fatty-liver-through-mitochondrial-reactive-oxygen-species-attenuation-in-rats
#16
Ghedeir M Alshammari, Aristatile Balakrishnan, Thirunavukkarasu Chinnasamy
One of the worldwide metabolic health dilemma is nonalcoholic fatty liver diseases (NAFLD). Researchers are searching effective drug to manage NAFLD patients. One of the best way to manage the metabolic imperfection is through natural principal isolated from different sources. Butein, a natural compound known to have numerous pharmacological application. In the current study we assessed the therapeutic effect of butein administration on liver function tests, oxidative stress, antioxidants, lipid abnormalities, serum inflammatory cytokines, and mitochondrial reactive oxygen species levels, in rats with methionine-choline deficient (MCD) diet induced NAFLD...
April 19, 2018: BioFactors
https://www.readbyqxmd.com/read/29671945/the-rs4686434-variant-in-the-fetub-locus-is-associated-with-intrahepatic-triglyceride-content-in-obese-chinese-adults
#17
Zhibin Li, Mingzhu Lin, Changqin Liu, Zheng Chen, Dongmei Wang, Xiulin Shi, Shuyu Yang, Xuejun Li
BACKGROUND: We aimed to explore associations of genetic variants in FETUB locus with intrahepatic triglyceride (IHTG) content. METHODS: We genotyped 4 tagging single-nucleotide polymorphisms (SNPs) of FETUB locus as well as PNPLA3 rs738409 and TM6SF2 rs58542926 in 418 obese Chinese adults who were measured on serum Fetuin-B and IHTG content. RESULTS: Subjects carrying the minor allele G for FETUB rs4686434 showed decreased serum Fetuin-B (AG/GG v...
April 19, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29670844/the-eeffect-of-metformin-combined-with-calcium-vitamin-d-3-against-diet-induced-nonalcoholic-fatty-liver-disease
#18
Sara Shojaei Zarghani, Samin Abbaszadeh, Mohammad Alizadeh, Maryam Rameshrad, Alireza Garjani, Hamid Soraya
Purpose: Metformin is one of the most popular drugs tested against nonalcoholic fatty liver disease (NAFLD). The present study aimed to investigate whether calcium-vitamin D3 cosupplementation will intensify the effect of metformin on the prevention of high-fat, high-fructose (HFFr) diet-induced hepatic steatosis. Methods: Male wistar rats (210±16 g) were assigned into the following seven groups: a Control group to receive a standard chow and six HFFr-fed groups to receive diets containing either normal (0...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29669855/squalene-epoxidase-drives-nafld-induced-hepatocellular-carcinoma-and-is-a-pharmaceutical-target
#19
Dabin Liu, Chi Chun Wong, Li Fu, Huarong Chen, Liuyang Zhao, Chuangen Li, Yunfei Zhou, Yanquan Zhang, Weiqi Xu, Yidong Yang, Bin Wu, Gong Cheng, Paul Bo-San Lai, Nathalie Wong, Joseph J Y Sung, Jun Yu
Nonalcoholic fatty liver disease (NAFLD)-induced hepatocellular carcinoma (HCC) is an emerging malignancy in the developed world; however, mechanisms that contribute to its formation are largely unknown, and targeted therapy is currently not available. Our RNA sequencing analysis of NAFLD-HCC samples revealed squalene epoxidase ( SQLE ) as the top outlier metabolic gene overexpressed in NAFLD-HCC patients. Hepatocyte-specific Sqle transgenic expression in mice accelerated the development of high-fat, high-cholesterol diet-induced HCC...
April 18, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29669730/drug-induced-alterations-of-mitochondrial-dna-homeostasis-in-steatotic-and-non-steatotic-heparg-cells
#20
Dounia Le Guillou, Simon Bucher, Karima Begriche, Delphine Hoet, Anne Lombes, Gilles Labbe, Bernard Fromenty
Although mitochondriotoxicity plays a major role in drug-induced hepatotoxicity, alteration of mitochondrial DNA (mtDNA) homeostasis has been described only with a few drugs. Because it requires long drug exposure, this mechanism of toxicity cannot be detected with investigations performed in isolated liver mitochondria or cultured cells exposed to drugs for several hours, or a few days. Thus, a first aim of this study was to determine whether a 2-week treatment with 9 hepatotoxic drugs could affect mtDNA homeostasis in HepaRG cells...
April 18, 2018: Journal of Pharmacology and Experimental Therapeutics
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