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Nonalcoholic fatty liver

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https://www.readbyqxmd.com/read/28827398/network-analyses-identify-liver-specific-targets-for-treating-liver-diseases
#1
Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park, Sumit Deshmukh, Azadeh M Harzandi, Tim Kuijpers, Morten Grøtli, Simon J Elsässer, Brian D Piening, Michael Snyder, Ulf Smith, Jens Nielsen, Fredrik Bäckhed, George Kunos, Mathias Uhlen, Jan Boren, Adil Mardinoglu
We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. We first generated co-expression networks (CNs) for 46 human tissues and liver cancer to explore the functional relationships between genes and examined the overlap between functional and physical interactions. Since increased de novo lipogenesis is a characteristic of nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC), we investigated the liver-specific genes co-expressed with fatty acid synthase (FASN)...
August 21, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/28820447/comprehensive-study-of-multiple-stages-progressing-to-nonalcoholic-steatohepatitis-with-subsequent-fibrosis-in-sd-rats
#2
Lulu Wang, Susu Wu, Minxuan Cai, Ji Ma, Shengcun Li, Maoru Li, Yan Xu, Lixin Wei, Jing Shang
Because of the absence of the time course of histological nonalcoholic fatty hepatitis with subsequent fibrotic progression, the effective approaches available for controlling the onset and progression of non-alcoholic steatohepatitis (NASH) remain limited. Therefore, we detected the serum and liver tissue related lipid metabolism disorder, liver pathology and relative molecular makers alteration dynamically in a high fat-sucrose diet during different time points. High fat-sucrose diet significantly increased the serum lipid level on day 10...
August 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28814531/patients-with-nonalcoholic-fatty-liver-disease-have-a-low-response-rate-to-vitamin-d-supplementation
#3
Jaividhya Dasarathy, Rony Varghese, Abram Feldman, Amer Khiyami, Arthur J McCullough, Srinivasan Dasarathy
Background: Hypovitaminosis D is associated with an increased severity of nonalcoholic fatty liver disease (NAFLD), but reports on the response to cholecalciferol (vitamin D3) supplementation are conflicting.Objective: The objective of this study was to determine if standard vitamin D3 supplementation is effective in NAFLD with hypovitaminosis D.Methods: Sixty-five well-characterized adults [age (mean ± SD): 51.6 ± 12.3 y] with biopsy-proven NAFLD were screened. Forty-two patients (the ratio of men to women was 13:29) had hypovitaminosis D (plasma 25-hydroxyvitamin D [25(OH)D] <30 ng/mL)...
August 16, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28811690/biochemical-profile-of-nonalcoholic-fatty-liver-disease-patients-in-eastern-india-with-histopathological-correlation
#4
Manorama Swain, Preetam Nath, Prasant Kumar Parida, Jimmy Narayan, Pradeep Kumar Padhi, Girish Kumar Pati, Ayaskanta Singh, Bijay Misra, Debasis Misra, Sanjib Kumar Kar, Manas Kumar Panigrahi, Chudamani Meher, Omprakash Agrawal, Niranjan Rout, Kaumudee Pattnaik, Pallavi Bhuyan, Pramila Kumari Mishra, Shivaram Prasad Singh
Aminotransferase assay is often used as a screening test as well as an endpoint for resolution of disease in nonalcoholic fatty liver disease (NAFLD). Aim of the study was to evaluate the relationship of transaminase level with metabolic variables and histology in NAFLD. Single center observational study was conducted in a gastroenterology clinic at Cuttack in coastal Odisha. Subjects were consecutive patients presenting with functional bowel disease and undergoing abdominal sonography. All participants were evaluated for the presence of metabolic syndrome (MS), insulin resistance, liver function test and lipid profile...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28808418/emerging-roles-of-sirt1-in-fatty-liver-diseases
#5
REVIEW
Ren-Bo Ding, Jiaolin Bao, Chu-Xia Deng
Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol consumption and/or other metabolic disorder causes, lead to serious medical concerns worldwide in recent years. It has been demonstrated that metabolic homeostasis disruption is most likely to be responsible for this global epidemic. Sirtuins are a group of conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone and/or protein deacetylases belonging to the silent information regulator 2 (Sir2) family...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28804621/development-of-gene-polymorphisms-in-meditators-of-nonalcoholic-fatty-liver-disease
#6
Chun Wang, Jianping Gong, Hao Wu
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, the morbidity of which closely correlates with diversity of ethnicity, minority, family and location. Its histology spans from simple steatosis, to nonalcoholic steatohepatitis, which ultimately results in fibrosis, cirrhosis and hepatocellular carcinoma. The accelerating prevalence of NAFLD is due to an incremental incidence of metabolic syndrome that is distinguished by dyslipidemia, glucose impairment, obesity, excessive oxidative stress and adipocytokine impairment...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28802640/nonalcoholic-fatty-liver-disease-associated-with-metabolic-syndrome-influence-of-liver-fibrosis-stages-on-characteristics-of-very-low-density-lipoproteins
#7
Diego Lucero, Verónica Miksztowicz, Gisela Gualano, Cristina Longo, Graciela Landeira, Estela Álvarez, Valeria Zago, Fernando Brites, Gabriela Berg, Eduardo Fassio, Laura Schreier
BACKGROUND: We evaluated possible changes in VLDLcharacteristics, and metabolic related factors, in MetS-associated NAFLD and accompanying liver fibrosis. METHODS: We studied 36 MetS patients with biopsy-proven NAFLD (MetS+NAFLD) and 24 MetS without ultrasound NAFLD evidence. Further, MetS+NAFLD was sub-divided according to fibrosis stage into, non-to-moderate (F0-F2, n=27) and severe (F3-F4, n=9) fibrosis. We measured: lipid profile, VLDL composition and size (size exclusion-HPLC), CETP and lipoprotein lipase (LPL) activities and adiponectin...
August 9, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28802566/alcohol-use-and-cardiovascular-disease-risk-in-patients-with-nonalcoholic-fatty-liver-disease
#8
Lisa B VanWagner, Hongyan Ning, Norrina B Allen, Veeral Ajmera, Cora E Lewis, John Jeffrey Carr, Donald M Lloyd-Jones, Norah A Terrault, Juned Siddique
BACKGROUND & AIMS: Cardiovascular disease (CVD) is the leading cause of death among patients with non-alcoholic fatty liver disease (NAFLD). Moderate drinking (vs abstinence) is associated with lower risk of CVD in the general population. We assessed whether alcohol use is associated with CVD risk in patients with NAFLD. METHODS: We analyzed data from participants in the Coronary Artery Risk Development in Young Adults longitudinal cohort study of 5115 black and white young adults, 18-30 years old, recruited from 4 cities in the United States from 1985 through 1986...
August 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28802062/modeling-the-epidemic-of-nonalcoholic-fatty-liver-disease-demonstrates-an-exponential-increase-in-burden-of-disease
#9
Chris Estes, Homie Razavi, Rohit Loomba, Zobair Younossi, Arun J Sanyal
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are highly prevalent in the US, where they are a growing cause of cirrhosis and hepatocellular carcinoma (HCC), and increasingly, an indicator for liver transplantation. METHODS: A Markov model was used to forecast NAFLD disease progression. Incidence of NAFLD was based on historical and projected changes in adult prevalence of obesity and type 2 diabetes mellitus (DM)...
August 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28799714/potential-biological-effects-of-epigallocatechin-3-gallate-on-the-treatment-of-nonalcoholic-fatty-liver-disease
#10
REVIEW
Cheng Chen, Qian Liu, Lin Liu, Yi-Yang Hu, Qin Feng
Nonalcoholic fatty liver disease (NAFLD) is a major health issue throughout the world. However, no validated treatments for NAFLD are currently available. In-depth studies have demonstrated the efficacy of (-)-epigallocatechin-3-gallate (EGCG), a main bioactive chemical extracted from green tea, in treating NAFLD. EGCG exhibits multi-pronged preventive and therapeutic activities, including promoting lipid and glucose metabolism, anti-lipid peroxidation and anti-inflammation activities, anti-fibrosis, and anti-NAFLD related tumor, thus contributing to the mitigation of NAFLD occurrence and progression...
August 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28796993/oral-administration-of-cardioaid-and-lunasin-alleviates-liver-damage-in-a-high-fat-diet-nonalcoholic-steatohepatitis-model
#11
Ariel Drori, Dvorah Rotnemer-Golinkin, Lidya Zolotarov, Yaron Ilan
BACKGROUND: Several of the drugs in development for treatment of nonalcoholic steatohepatitis (NASH) target liver fibrosis or have side effects that prohibit their long-term use in patients with mild to moderate disease. Lunasin is a soy-derived peptide with anti-inflammatory properties. ADM's CardioAid™ is a plant sterol extract that exerts cholesterol- and triacylglycerol-lowering effects. AIM: To determine the immunomodulatory effects of CardioAid and lunasin in a high-fat diet (HFD) animal model of NASH...
August 11, 2017: Digestion
https://www.readbyqxmd.com/read/28796629/hepatic-lipid-accumulation-and-nrf2-expression-following-perinatal-and-peripubertal-exposure-to-bisphenol-a-in-a-mouse-model-of-nonalcoholic-liver-disease
#12
Prajakta C Shimpi, Vijay R More, Maneesha Paranjpe, Ajay C Donepudi, Jaclyn M Goodrich, Dana C Dolinoy, Beverly Rubin, Angela L Slitt
BACKGROUND: Exposure to chemicals during critical windows of development may re-program liver for increased risk of nonalcoholic fatty liver disease (NAFLD). Bisphenol A (BPA), a plastics component, has been described to impart adverse effects during gestational and lactational exposure. Our work has pointed to nuclear factor E2-related factor 2 (Nrf2) being a modulator of hepatic lipid accumulation in models of NAFLD. OBJECTIVES: To determine if chemical exposure can prime liver for steatosis via modulation of NRF2 and epigenetic mechanisms...
August 4, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28796410/steatosis-severity-affects-the-diagnostic-performances-of-noninvasive-fibrosis-tests-in-nonalcoholic-fatty-liver-disease
#13
Sae Kyung Joo, Won Kim, Donghee Kim, Jung Ho Kim, Sohee Oh, Kook Lae Lee, Mee Soo Chang, Yong Jin Jung, Young Ho So, Myoung Seok Lee, Jeong Mo Bae, Byeong Gwan Kim
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of heterogeneous metabolic subtypes. This study compared the diagnostic performances of noninvasive fibrosis tests in predicting advanced fibrosis in patients with NAFLD and examined the effects of the subgroup on their diagnostic performances. METHODS: Three hundred fifteen patients with biopsy-proven NAFLD were prospectively enrolled. Acoustic radiation force impulse imaging (ARFI) was performed to obtain liver stiffness measurements (LSMs)...
August 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28796060/candidate-genes-investigation-for-severe-nonalcoholic-fatty-liver-disease-based-on-bioinformatics-analysis
#14
Shan Qi, Changhong Wang, Chunfu Li, Pu Wang, Minghui Liu
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver condition worldwide. However, its etiology and fundamental pathophysiology for the disease process are poorly understood. In this study, we thus used bioinformatics to identify candidate genes potentially causative of severe NAFLD. METHODS: Gene expression profile data GSE49541 were downloaded from the Gene Expression Omnibus database. Tissues samples from 32 severe and 40 mild NAFLD patients were evaluated to identify differentially expressed genes (DEGs) between the 2 groups, followed by analyses of Gene Ontology (GO) functions and Kyoto Encyclopedia of Genes and Genomes pathways...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28796003/the-care-of-the-postliver-transplant-patient
#15
Mark W Russo
Since 1988 nearly 150,000 liver transplants have been performed in the United States. Over the past 3 decades the indications for liver transplant have changed from end-stage liver disease from alcohol and cholestatic liver diseases to hepatitis C and most recently nonalcoholic fatty liver disease. Liver transplant recipients are living longer with 10-year survival rates exceeding 60%. Gastroenterologists are likely to encounter or consult on postliver transplant recipients as they live longer and seek care closer to home...
September 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28795381/research-progress-on-prevention-and-treatment-of-glucolipid-metabolic-disease-with-integrated-traditional-chinese-and-western-medicine
#16
Jiao Guo
Hyperlipidemia, type 2 diabetes mellitus, nonalcoholic fatty liver and many other metabolic disorder are frequently co-existing in patients. In addition, these diseases are closely related in pathophysiological settings. However, increasing of the disease incidence, lacking of comprehensive prevention and control measurements against the key pathology point concomitant occurrence with the pattern of the single disease, single target therapy, that is leading therapeutic strategy for these metabolic disorders in the setting of Western medicine (WM)...
June 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28795140/resting-and-exercise-energy-metabolism-after-liver-transplantation-for-nonalcoholic-steatohepatitis
#17
Josh Levitsky, Ajay Singhvi, H Steven Sadowsky, Ayelet Cohen, Alysen Demzik, Lisa VanWagner, Mary Rinella
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a leading indication for liver transplantation (LT). We hypothesized that weight gain after LT may be exacerbated by reduced metabolic rates due to the LT procedure, particularly during exercise. We aimed to compare resting and exercise energy expenditure between patients transplanted for NASH and nontransplant nonalcoholic fatty liver disease (NAFLD) subjects. METHODS: NASH LT recipients (>1-year post, n = 14) and NAFLD controls (n = 13) underwent analysis of body composition, resting energy expenditure (REE), and exercise energy expenditure (VO2max), the latter using a ramped-Bruce protocol assessed by expired gas analysis and peak heart rate...
August 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28791556/the-clinical-implications-of-fatty-pancreas-a-concise-review
#18
REVIEW
Tawfik Khoury, Akwi W Asombang, Tyler M Berzin, Jonah Cohen, Douglas K Pleskow, Meir Mizrahi
Fatty pancreas is a newly recognized condition which is poorly investigated until today as compared to nonalcoholic fatty liver disease. It is characterized by pancreatic fat accumulation and subsequent development of pancreatic and metabolic complications. Association of fatty pancreas have been described with type 2 diabetes mellitus, acute and chronic pancreatitis and even pancreatic carcinoma. In this review article, we provide an update on clinical implications, pathogenesis, diagnosis, treatment and outcomes...
August 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28790196/trif-dependent-toll-like-receptor-signaling-suppresses-scd1-transcription-in-hepatocytes-and-prevents-diet-induced-hepatic-steatosis
#19
Jing Chen, Jin Li, Jensen H C Yiu, Jenny K W Lam, Chi-Ming Wong, Bernhard Dorweiler, Aimin Xu, Connie W Woo
Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of diseases that ranges in severity from hepatic steatosis to steatohepatitis, the latter of which is a major predisposing factor for liver cirrhosis and cancer. Toll-like receptor (TLR) signaling, which is critical for innate immunity, is generally believed to aggravate disease progression by inducing inflammation. Unexpectedly, we found that deficiency in TIR domain-containing adaptor-inducing interferon-β (TRIF), a cytosolic adaptor that transduces some TLR signals, worsened hepatic steatosis induced by a high-fat diet (HFD) and that such exacerbation was independent of myeloid cells...
August 8, 2017: Science Signaling
https://www.readbyqxmd.com/read/28789977/ablation-of-systemic-sirt1-activity-promotes-nonalcoholic-fatty-liver-disease-by-affecting-liver-mesenteric-adipose-tissue-fatty-acid-mobilization
#20
Junrui Cheng, Chun Liu, Kangquan Hu, Andrew Greenberg, Dayong Wu, Lynne M Ausman, Michael W McBurney, Xiang-Dong Wang
Sirtuin 1 (SIRT1) has been reported to protect against nonalcoholic fatty liver disease (NAFLD) development. The mechanism of how SIRT1 deacetylase activity affects NAFLD has not been well investigated. The current investigation addressed the causal effect of systemic SIRT1 activity on NAFLD development and the underlying mechanism involved in both liver and mesenteric adipose tissue (MAT). Both SIRT1 homozygous mice ablated the catalytic activity (sirt1(Y/Y)) and their corresponding wild type littermates (WT) were fed a high fat diet (HFD, 60% calories from fat) for 34weeks...
August 5, 2017: Biochimica et Biophysica Acta
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