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Nonalcoholic fatty liver

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https://www.readbyqxmd.com/read/29913455/grape-leucoanthocyanidin-protects-liver-tissue-in-albino-rabbits-with-nonalcoholic-hepatic-steatosis
#1
Reginaldo Franklin, Rodrigo Freitas Monte Bispo, Célio Fernando Sousa-Rodrigues, Lucas Alves Sarmento Pires, Albino Fonseca, Marcio Antonio Babinski
Nonalcoholic fatty liver disease (NAFLD) is a common ailment. It is usually found in association with diabetes or obesity. There are no approved drugs to treat this condition. The study of flavonoid consumption has increased over the decades due to their antioxidative properties, although the literature is scarce when it comes to their effects in liver tissue. The purpose of this study was to evaluate the role of leucoanthocyanidin in nonalcoholic hepatic steatosis. Thirty male albino rabbits were divided in 3 groups...
June 18, 2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29913275/rates-and-factors-associated-with-placebo-response-in-trials-of-pharmacotherapies-for-nonalcoholic-steatohepatitis-systematic-review-and-meta-analysis
#2
REVIEW
Ma Ai Thanda Han, Osama Altayar, Shadi Hamdeh, Varun Takyar, Yaron Rotman, Ohad Etzion, Eric Lefebvre, Rifaat Safadi, Vlad Ratziu, Larry J Prokop, Mohammad Hassan Murad, Mazen Noureddin
BACKGROUND & AIMS: Understanding the extent of the placebo effect in randomized controlled trials of studying nonalcoholic steatohepatitis (NASH) is important for optimal trial design, including sample size calculations and treatment endpoint definition. METHODS: We performed a systematic review and meta-analysis of the placebo groups from randomized controlled trials of adults with NASH that provided histological and/or magnetic resonance image-based measurements of intrahepatic triglyceride...
June 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29912756/hyperlipidemia-and-nonalcoholic-steatohepatitis-predispose-to-hepatocellular-carcinoma-development-without-cirrhosis
#3
Jennifer Phan, Vivian Ng, Alan Sheinbaum, Sam French, Gina Choi, Mohamed El Kabany, Francisco Durazo, Sammy Saab, Myron Tong, Ronald Busuttil, Steven-Huy Han
BACKGROUND: Hepatocellular carcinoma (HCC) accounts for 90% of primary hepatic malignancies. With the exception of chronic hepatitis B (CHB), other etiologies of chronic liver disease require progression to cirrhosis before HCC development. Case reports have described HCC in noncirrhotic patients with hepatitis C (HCV) and nonalcoholic fatty liver disease. GOAL: The aim of this study was to determine the prevalence of patients without cirrhosis and CHB who developed HCC among a large cohort of HCC patients and to identify independent variables that are associated with no cirrhosis among patients with HCC...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29908362/magnetic-resonance-vs-transient-elastography-analysis-of-patients-with-non-alcoholic-fatty-liver-disease-a-systematic-review-and-pooled-analysis-of-individual-participants
#4
Cynthia Hsu, Cyrielle Caussy, Kento Imajo, Jun Chen, Siddharth Singh, Kellee Kaulback, Minh-Da Le, Jonathan Hooker, Xin Tu, Ricki Bettencourt, Meng Yin, Claude B Sirlin, Richard L Ehman, Atsushi Nakajima, Rohit Loomba
BACKGROUND & AIMS: Magnetic resonance elastography (MRE) and transient elastography (TE) are noninvasive techniques for detection of liver fibrosis. Single-center studies have compared the diagnostic performance of MRE vs TE in patients with nonalcoholic fatty liver disease (NAFLD). We conducted a pooled analysis of individual participant data from published studies to compare the diagnostic performance of MRE vs TE for staging of liver fibrosis in patients with NAFLD, using liver biopsy as reference...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29904722/underrated-enemy-from-nonalcoholic-fatty-liver-disease-to-cancers-of-the-gastrointestinal-tract
#5
REVIEW
Aleksandra Derra, Martyna Bator, Tomasz Menżyk, Michał Kukla
Nonalcoholic fatty liver disease (NAFLD) is intrahepatic ectopic lipid deposition which is present despite a lack of other causes of secondary hepatic fat accumulation. It is the most common chronic liver disorder in the welldeveloped countries. NAFLD is a multidisciplinary disease that affects various systems and organs and is inextricably linked to simple obesity, metabolic syndrome, insulin resistance and overt diabetes mellitus type 2. The positive energy balance related to obesity leads to a variety of systemic changes including modified levels of insulin, insulin- like growth factor-1, adipokines, hepatokines and cytokines...
June 2018: Clinical and experimental hepatology
https://www.readbyqxmd.com/read/29903531/pediatric-nonalcoholic-fatty-liver-disease-in-new-york-city-an-autopsy-study
#6
Danielle M Fernandes, Vivek Pantangi, Muhammad Azam, Marcela Salomao, Alina C Iuga, Jay H Lefkowitch, James Gill, Raffaella Morotti, Joel E Lavine, Ali A Mencin
OBJECTIVE: To assess the prevalence and severity of nonalcoholic liver disease (NAFLD) in children in a diverse population sample in New York City. STUDY DESIGN: Liver specimens were examined from children 2-19 years old who died of unexpected causes within 48 hours of medical presentation and underwent autopsy in New York City from 2005 to 2010. Records were reviewed for age, sex, weight, height, and race. Two hepatopathologists evaluated each liver specimen to determine pathologic diagnosis...
June 11, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29903515/the-nonalcoholic-fatty-liver-disease-nafld-fibrosis-score-cardiovascular-risk-stratification-and-a-strategy-for-secondary-prevention-with-ezetimibe
#7
Tracey G Simon, Kathleen E Corey, Christopher P Cannon, Michael Blazing, Jeong-Gun Park, Michelle L O'Donoghue, Raymond T Chung, Robert P Giugliano
OBJECTIVE: The nonalcoholic fatty liver disease fibrosis score (NFS) is comprised of unique metabolic risk indicators that may accurately predict residual cardiovascular (CV) risk in patients with established coronary disease and metabolic dysfunction. METHODS: We applied the NFS prospectively to 14,819 post-ACS patients randomized to ezetimibe/simvastatin (E/S) or placebo/simvastatin (P/S), in the IMPROVE-IT trial, using validated NFS cutoffs. The primary endpoint included CV death, myocardial infarction, unstable angina, revascularization or stroke...
May 26, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29903170/-association-of-single-nucleotide-polymorphism-of-sirt1-and-apoc3-with-nonalcoholic-fatty-liver-disease
#8
Xiaochao Song, Chunli Song, Li Fan, Qinghua Ma, Jianliang Mao, Wenxin Xu, Xinli Li
OBJECTIVE: To explore the association of silent information regulator 1( SIRT1) rs12778366 and apolipoprotein C3( APOC3) rs2854116 gene polymorphisms with the susceptibility of nonalcoholic fatty liver disease( NAFLD). METHODS: One hundred and thirty two NAFLD patients and 252 healthy controls were enrolled in our present study according to the ultrasound diagnosis and physical examination. Venousblood samples were obtained in the morning after an overnight fast, and the samples were used to analyze the biochemical index, relating to hepatic enzymes, blood lipid and blood glucose metabolism...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29901549/a-bibliometric-analysis-of-clinical-and-translational-research-in-pediatric-gastroenterology-from-1970-to-2017
#9
Melanie H Schwimmer, Mary Catherine Sawh, Karen M Heskett, Nidhi P Goyal, Kimberly P Newton, Jeffrey B Schwimmer
OBJECTIVES: Pediatric gastroenterology is a clinical and research discipline principally developed over the past 50 years. Bibliometric methods provide quantitative analysis and identify research trends. Study aims were to characterize the growth and trends in pediatric gastroenterology clinical and translational research using citation analysis. METHODS: Using citations analysis software, a search strategy specific for pediatric gastroenterology was implemented for the years 1970-2017...
June 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29898759/exosomes-released-by-hepatocarcinoma-cells-endow-adipocytes-with-tumor-promoting-properties
#10
Shihua Wang, Meiqian Xu, Xiaoxia Li, Xiaodong Su, Xian Xiao, Armand Keating, Robert Chunhua Zhao
BACKGROUND: The initiation and progression of hepatocellular carcinoma (HCC) are largely dependent on its local microenvironment. Adipocytes are an important component of hepatic microenvironment in nonalcoholic fatty liver disease (NAFLD), which is a significant risk factor for HCC. Given the global prevalence of NAFLD, a better understanding of the interplay between HCC cells and adipocytes is urgently needed. Exosomes, released by malignant cells, represent a novel way of cell-cell interaction and have been shown to play an important role in cancer cell communication with their microenvironment...
June 14, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29898626/glucoraphanin-a-broccoli-sprout-extract-that-ameliorates-obesity-induced-inflammation-and-insulin-resistance
#11
Liang Xu, Naoto Nagata, Tsuguhito Ota
Obesity is a low-grade sustained inflammatory state that causes oxidative stress in different metabolic tissues, which leads to insulin resistance and nonalcoholic fatty liver disease (NAFLD). Particularly, obesity-induced metabolic endotoxemia plays an important role in the pathogenesis of insulin resistance and inflammation. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of antioxidant signaling that serves as a primary cellular defense against the cytotoxic effects of oxidative stress...
June 14, 2018: Adipocyte
https://www.readbyqxmd.com/read/29897928/nonalcoholic-fatty-liver-disease-with-elevated-alanine-aminotransferase-levels-is-negatively-associated-with-bone-mineral-density-cross-sectional-study-in-u-s-adults
#12
Toshihiro Umehara
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has been reported to have a negative effect on bone mineral density (BMD) in Asian populations. Whether such an association exists in Western populations is less clear. METHODS: This cross-sectional analysis of data from NHANES III, a United States national health survey conducted from 1988 to 1994, included 6089 participants aged 40-75 years, selected after excluding people with hepatitis virus serology, elevated alcohol consumption, decreased renal function, or steroid use, and pregnant females...
2018: PloS One
https://www.readbyqxmd.com/read/29895557/effect-of-empagliflozin-on-liver-fat-in-patients-with-type-2-diabetes-and-nonalcoholic-fatty-liver-disease-a-randomized-controlled-trial-e-lift-trial
#13
Mohammad Shafi Kuchay, Sonal Krishan, Sunil Kumar Mishra, Khalid Jamal Farooqui, Manish Kumar Singh, Jasjeet Singh Wasir, Beena Bansal, Parjeet Kaur, Ganesh Jevalikar, Harmendeep Kaur Gill, Narendra Singh Choudhary, Ambrish Mithal
OBJECTIVE: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have been shown to reduce liver fat in rodent models. Data regarding the effect of SGLT-2 inhibitors on human liver fat are scarce. This study examined the effect of empagliflozin (an SGLT-2 inhibitor) on liver fat in patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) by using MRI-derived proton density fat fraction (MRI-PDFF). RESEARCH DESIGN AND METHODS: Fifty patients with type 2 diabetes and NAFLD were randomly assigned to either the empagliflozin group (standard treatment for type 2 diabetes plus empagliflozin 10 mg daily) or the control group (standard treatment without empagliflozin) for 20 weeks...
June 12, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29894414/risk-factors-and-clinical-course-for-liver-steatosis-or-nonalcoholic-steatohepatitis-after-living-donor-liver-transplantation
#14
Hisamitsu Miyaaki, Satoshi Miuma, Naota Taura, Hidetaka Shibata, Ryu Sasaki, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Susumu Eguchi, Kazuhiko Nakao
BACKGROUND: Posttransplant liver steatosis occurs frequently and can affect patient outcome. Our aim was to clarify the risk factors for steatosis or steatohepatitis after living donor liver transplantation (LT) through a retrospective examination of recent 100 living donor LT recipients and their liver donors. METHODS: Liver biopsy was performed at 1-year after LT and each year, thereafter, or as needed due to abnormal liver enzyme levels, with a median follow-up of 4 (2~10) years...
June 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29893699/impact-of-diabetes-mellitus-and-insulin-on-nonalcoholic-fatty-liver-disease-in-the-morbidly-obese
#15
Cláudia B M Strey, Luiz A de Carli, Marciane Fantinelli, Sabrina S Gobbato, Guilherme F Bassols, Alexandre Losekann, Gabriela P Coral
INTRODUCTION AND AIM: The prevalence of obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease are increasing. Type 2 diabetes mellitus may aggravate non-alcoholic fatty liver disease, increasing the risk of developing cirrhosis and hepatocellular carcinoma. This study aims to determine the effect of type 2 diabetes mellitus and insulin therapy on non-alcoholic fatty liver disease in the patients with morbid obesity. MATERIAL AND METHODS: Clinical, anthropometric and laboratory data were analyzed together with intraoperative liver biopsies from morbidly obese patients undergoing bariatric surgery...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893698/association-between-serum-hemoglobin-levels-and-non-alcoholic-fatty-liver-disease-in-a-mexican-population
#16
Eva Juárez-Hernández, Norberto C Chávez-Tapia, Diana C Brizuela-Alcántara, Misael Uribe, Martha H Ramos-Ostos, Natalia Nuño-Lámbarri
INTRODUCTION AND AIM: Nonalcoholic fatty liver disease (NAFLD) is closely associated with overweight and obesity, becoming one of the most prevalent hepatic diseases nowadays. Circulating hemoglobin (Hb) concentration is significantly higher in people with NAFLD, compared to healthy patients. While liver biopsy remains the gold standard for NAFLD diagnosis, it is not the best technique due to adverse events that may occur. Therefore it is important to find less invasive and more sensitive markers...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29892163/nonalcoholic-fatty-liver-disease-remission-in-men-through-regular-exercise
#17
Takafumi Osaka, Yoshitaka Hashimoto, Masahide Hamaguchi, Takao Kojima, Akihiro Obora, Michiaki Fukui
Recent cross-sectional and randomized controlled studies of small sample sizes revealed that regular exercise is effective for improving nonalcoholic fatty liver disease. However, there has been no large-scale longitudinal study addressing the effect of regular exercise on remission of nonalcoholic fatty liver disease. Thus, we investigated the impact of exercise on the natural history of nonalcoholic fatty liver disease. We analyzed 1,010 (860 men and 150 women) Japanese participants who received health checkups repeatedly over 10 years by a historical cohort study and were diagnosed with nonalcoholic fatty liver disease at baseline...
May 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29890569/combined-effects-of-synbiotic-and-sitagliptin-versus-sitagliptin-alone-in-patients-with-nonalcoholic-fatty-liver-disease
#18
Saba Sayari, Hassan Neishaboori, Maryam Jameshorani
Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases in recent years. The aim of this study was to evaluate the effects of sitagliptin with and without a synbiotic supplement in the treatment of patients with NAFLD. Methods: In total, 138 NAFLD patients aged 18-60 years were enrolled in the study. Patients were randomized to one of the following treatments for 16 weeks: Group I (n=68), sitagliptin 50 mg daily plus placebo (one capsule per day) or group II (n=70) sitagliptin 50 mg daily plus synbiotic (one capsule per day)...
June 12, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29890411/analysis-of-proautophagic-activities-of-citrus-flavonoids-in-liver-cells-reveals-the-superiority-of-a-natural-polyphenol-mixture-over-pure-flavones
#19
Antonella Lascala, Concetta Martino, Maddalena Parafati, Raffaele Salerno, Manuela Oliverio, Daniela Pellegrino, Vincenzo Mollace, Elzbieta Janda
Autophagy dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Natural compounds present in bergamot polyphenol fraction (BPF) prevent NAFLD and induce autophagy in rat livers. Here, we employed HepG2 cells expressing DsRed-LC3-GFP, a highly sensitive model system to screen for proautophagic compounds present in BPF. BPF induced autophagy in a time- and dose-dependent fashion and the effect was amplified in cells loaded with palmitic acid. Autophagy was mediated by the hydrophobic fraction of acid-hydrolyzed BPF (A-BPF), containing six flavanone and flavone aglycones as identified by liquid chromatography-high-resolution mass spectrometry...
April 26, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29890010/repeating-measurements-by-transient-elastography-in-nonalcoholic-fatty-liver-disease-patients-with-high-liver-stiffness
#20
Jeremy Chak-Lun Chow, Grace Lai-Hung Wong, Anthony Wing-Hung Chan, Sally She-Ting Shu, Carmen Ka-Man Chan, Julie Ka-Yu Leung, Paul Cheung-Lung Choi, Angel Mei-Ling Chim, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
BACKGROUND AND AIM: The Baveno VI Consensus recommends repeating examination in patients with high liver stiffness measurement (LSM) by transient elastography to reduce false-positive diagnosis of advanced liver disease. We tested whether repeating transient elastography can increase the overall diagnostic accuracy. METHODS: Ninety-seven patients with non-alcoholic fatty liver disease (NAFLD) who underwent two FibroScan examinations within 6 months prior to liver biopsy were evaluated...
June 11, 2018: Journal of Gastroenterology and Hepatology
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