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https://www.readbyqxmd.com/read/28817289/how-to-drive-a-flashing-electron-ratchet-to-maximize-current
#1
Ofer Kedem, Bryan Lau, Emily A Weiss
Biological systems utilize a combination of asymmetry, noise, and chemical energy to produce motion in the highly damped environment of the cell with molecular motors, many of which are "ratchets", non-equilibrium devices for producing directed transport using non-directional perturbations, without a net bias. The underlying ratchet principle has been implemented in man-made micro- and nano-devices, to transport charged particles by oscillating an electric potential with repeating asymmetric features. In this experimental study, the ratcheting of electrons in an organic semiconductor is optimized by tuning the temporal modulation of the oscillating potential, applied using nanostructured electrodes...
August 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28816087/small-diameter-vascular-graft-with-fibroblast-cells-and-electrospun-poly-l-lactide-co-%C3%AE%C2%B5-caprolactone-scaffolds-cell-matrix-engineering
#2
Bong Seok Jang, Ja Young Cheon, Soo Hyun Kim, Won Ho Park
Electrospun scaffolds have been widely used in tissue engineering due to their similar structure to native extracellular matrices (ECM). However, one of the obstacles limiting the application of electrospun scaffolds for tissue engineering is the nano-sized pores, which inhibit cell infiltration into the scaffolds. To overcome this limitation, we approached to make layers which are consisted of cells onto the electrospun sheet and then tubular structure was constructed by rolling. We called this as "Cell Matrix Engineering" because the electrospun sheets were combined with the cells to form one matrix...
August 17, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28816007/fluorous-phase-directed-peptide-assembly-affords-nano-peptisomes-capable-of-ultrasound-triggered-cellular-delivery
#3
Scott H Medina, Megan S Michie, Stephen E Miller, Martin J Schnermann, Joel P Schneider
Here, we report the design, synthesis and efficacy of a new class of ultrasound (US)-sensitive self-assembled peptide-based nanoparticle. Peptisomes are prepared via templated assembly of a de novo designed peptide at the interface of fluorinated nanodroplets. Utilizing peptide assembly allows for facile particle synthesis, direct incorporation of bioactive sequences displayed from the particle corona, and the ability to easily encapsulate biologics during particle preparation using a mild solvent exchange procedure...
August 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28809456/real-time-intracellular-measurements-of-ros-and-rns-in-living-cells-with-single-core-shell-nanowire-electrodes
#4
Xin-Wei Zhang, Quan-Fa Qiu, Hong Jiang, Fu-Li Zhang, Yan-Ling Liu, Christian Amatore, Wei-Hua Huang
Nanoelectrodes allow precise and quantitative measurements of important biological processes at the single living cell level in real time. Cylindrical nanowires electrodes (NWEs) required for intracellular measurements create a great challenge for keeping excellent electrochemical and mechanical performances. Herein, we disclose a facile and robust solution to this problem based on a SiC-core-shell unique design to produce cylindrical NWEs with superior mechanical toughness provided by the SiC nano-core and excellent electrochemical performances brought by the ultrathin carbon shell that can be used as such or platinized...
August 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28809092/particle-targeting-in-complex-biological-media
#5
REVIEW
Qiong Dai, Nadja Bertleff-Zieschang, Julia A Braunger, Mattias Björnmalm, Christina Cortez-Jugo, Frank Caruso
Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, including diagnosis, imaging, and therapy. When functionalized with targeting ligands, these particles have the potential to interact with specific cells and tissues, and accumulate at desired target sites, reducing side effects and improve overall efficacy in applications such as vaccination and drug delivery. However, when targeted particles enter a complex biological environment, the adsorption of biomolecules and the formation of a surface coating (e...
August 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28807883/simultaneous-afm-topography-and-recognition-imaging-at-the-plasma-membrane-of-mammalian-cells
#6
REVIEW
Lilia A Chtcheglova, Peter Hinterdorfer
Elucidation the nano-organization of membrane proteins at/within the plasma membrane is probably the most demanding and still challenging task in cell biology since requires experimental approaches with nanoscale resolution. During last decade, atomic force microscopy (AFM)-based simultaneous topography and recognition imaging (TREC) has become a powerful tool to quickly obtain local receptor nano-maps on complex heterogeneous biosurfaces such as cells and membranes. Here we emphasize the TREC technique and explain how to unravel the nano-landscape of mammalian cells...
August 11, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28806146/three-dimensional-bioprinting-of-polycaprolactone-reinforced-gene-activated-bioinks-for-bone-tissue-engineering
#7
Gráinne M Cunniffe, Tomas Gonzalez-Fernandez, Andrew Daly, Binulal N Sathy, Oju Jeon, Eben Alsberg, Daniel J Kelly
Regeneration of complex bone defects remains a significant clinical challenge. Multi-tool biofabrication has permitted the combination of various biomaterials to create multifaceted composites with tailorable mechanical properties and spatially controlled biological function. In this study we sought to use bioprinting to engineer nonviral gene activated constructs reinforced by polymeric micro-filaments. A gene activated bioink was developed using RGD-γ-irradiated alginate and nano-hydroxyapatite (nHA) complexed to plasmid DNA (pDNA)...
August 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28803044/new-racemic-annulated-pyrazolo-1-2-b-phthalazines-as-tacrine-like-ache-inhibitors-with-potential-use-in-alzheimer-s-disease
#8
Leili Jalili-Baleh, Hamid Nadri, Alireza Moradi, Syed Nasir Abbas Bukhari, Mojtaba Shakibaie, Mandana Jafari, Mostafa Golshani, Farshad Homayouni Moghadam, Loghman Firoozpour, Ali Asadipour, Saeed Emami, Mehdi Khoobi, Alireza Foroumadi
A novel series of tacrine-like compounds 7a-u possessing a fused pyrazolo[1,2-b]phthalazine structure were designed and synthesized as potent and selective inhibitors of AChE. The in-vitro biological assessments demonstrated that several compounds had high anti-AChE activity at nano-molar level. The more promising compound 7l with IC50 of 49 nM was 7-fold more potent than tacrine and unlike tacrine, it was highly selective against AChE over BuChE. The cell-based assays against hepatocytes (HepG2) and neuronal cell line (PC12) revealed that 7l had significantly lower hepatotoxicity compared to tacrine, with additional neuroprotective activity against H2O2-induced damage in PC12 cells...
July 31, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28803025/the-effect-of-nano-tio2-photocatalysis-on-the-antioxidant-activities-of-cu-zn-sod-at-physiological-ph
#9
Wen Zheng, Hai-Feng Zou, Shao-Wu Lv, Yan-Hong Lin, Min Wang, Fei Yan, Ye Sheng, Yan-Hua Song, Jie Chen, Ke-Yan Zheng
Security issues of nanoparticles on biological toxicity and potential environmental risk have attracted more and more attention with the rapid development and wide applications of nanotechnology. In this work, we explored the effect and probable mechanism of nano-TiO2 on antioxidant activity of copper, zinc superoxide dismutase (Cu, Zn-SOD) under natural light and mixed light at physiological pH. Nano-TiO2 was prepared by sol-hydrothermal method, and then characterized by X-ray Diffraction (XRD) and Transmission electron micrographs (TEM)...
August 5, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28802948/modelling-the-toxicity-of-a-large-set-of-metal-and-metal-oxide-nanoparticles-using-the-ochem-platform
#10
Vasyl Kovalishyn, Natalia Abramenko, Iryna Kopernyk, Larysa Charochkina, Larysa Metelytsia, Igor V Tetko, Willie Peijnenburg, Leonid Kustov
Inorganic nanomaterials have become one of the new areas of modern knowledge and technology and have already found an increasing number of applications. However, some nanoparticles show toxicity to living organisms, and can potentially have a negative influence on environmental ecosystems. While toxicity can be determined experimentally, such studies are time consuming and costly. Computational toxicology can provide an alternative approach and there is a need to develop methods to reliably assess Quantitative Structure-Property Relationships for nanomaterials (nano-QSPRs)...
August 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28801970/lysozyme-oxidation-by-singlet-molecular-oxygen-peptides-characterization-using-18-o-labeling-oxygen-and-nlc-ms-ms
#11
Emerson Finco Marques, Marisa H G Medeiros, Paolo Di Mascio
Singlet molecular oxygen ((1) O2 ) is generated in biological systems and reacts with different biomolecules. Proteins are a major target for (1) O2 and His, Tyr, Met, Cys and Trp are oxidized at physiological pH. In the present study, the modification of lysozyme protein by (1) O2 was investigated using mass spectrometry approaches. The experimental findings showed methionine, histidine and tryptophan oxidation. The experiments were achieved using [(18) O]-labeled (1) O2 released from thermolabile endoperoxides in association with nano-scale liquid chromatography coupled to electrospray ionization mass spectrometry, an UHR-ESI-Q-TOF...
August 11, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28798868/facile-synthesis-of-nano-sized-cufe2s3-morphology-and-diverse-functional-tuning-and-crystal-growth-mechanism-exploring
#12
Xiao Zhang, Huan Zhao, Yuda Zhu, You Yang, Dongli Jiang, Xiaoqin Chen, Jing Sun, Jiaoming Luo, Bing Cai, Hongsong Fan
Ternary chalcogenide compounds are such promising and have been used for much practical applications. As a sort of these compounds, cubanite (CuFe2S3) possess some unique properties which can be used in different fields. In our study, we developed a facile one pot synthesis of CuFe2S3 nanocrystals (NCs) at a low reaction temperature, and achieved a morphology and phase composition tuning of the NCs through changing a variety of precursors and surfactants, meanwhile improved their magnetism and optical properties...
August 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28795697/perovskite-based-photodetectors-materials-and-devices
#13
REVIEW
Huan Wang, Dong Ha Kim
While the field of perovskite-based optoelectronics has mostly been dominated by photovoltaics, light-emitting diodes, and transistors, semiconducting properties peculiar to perovskites make them interesting candidates for innovative and disruptive applications in light signal detection. Perovskites combine effective light absorption in the broadband range with good photo-generation yield and high charge carrier mobility, a combination that provides promising potential for exploiting sensitive and fast photodetectors that are targeted for image sensing, optical communication, environmental monitoring or chemical/biological detection...
August 10, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28782570/nanomedicine-and-advanced-technologies-for-burns-preventing-infection-and-facilitating-wound-healing
#14
Mirza Ali Mofazzal Jahromi, Parham Sahandi Zangabad, Seyed Masoud Moosavi Basri, Keyvan Sahandi Zangabad, Ameneh Ghamarypour, Amir R Aref, Mahdi Karimi, Michael R Hamblin
According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections...
August 3, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28782037/chemotactic-synthetic-vesicles-design-and-applications-in-blood-brain-barrier-crossing
#15
Adrian Joseph, Claudia Contini, Denis Cecchin, Sophie Nyberg, Lorena Ruiz-Perez, Jens Gaitzsch, Gavin Fullstone, Xiaohe Tian, Juzaili Azizi, Jane Preston, Giorgio Volpe, Giuseppe Battaglia
In recent years, scientists have created artificial microscopic and nanoscopic self-propelling particles, often referred to as nano- or microswimmers, capable of mimicking biological locomotion and taxis. This active diffusion enables the engineering of complex operations that so far have not been possible at the micro- and nanoscale. One of the most promising tasks is the ability to engineer nanocarriers that can autonomously navigate within tissues and organs, accessing nearly every site of the human body guided by endogenous chemical gradients...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28780997/electrochemical-carbon-based-nanosensors-a-promising-tool-in-pharmaceutical-and-biomedical-analysis
#16
REVIEW
Sevinc Kurbanoglu, Sibel A Ozkan
Nanotechnology has become very popular in the sensor fields in recent times. It is thought that the utilization of such technologies, as well as the use of nanosized materials, could well have beneficial effects for the performance of sensors. Nano-sized materials have been shown to have a number of novel and interesting physical and chemical properties. Low-dimensional nanometer-sized materials and systems have defined a new research area in condensed-matter physics within past decades. Apart from the aforesaid categories of materials, there exist various materials of different types for fabricating nanosensors...
June 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28778061/studies-on-the-interaction-of-polylactid-based-planar-and-nanoparticular-biomaterials-with-serum-albumin-and-fibrinogen
#17
Katharina Wulf, Ulrike Tschierschky, Thomas Eickner, Niels Grabow, Ralf G Mundkowski
Knowledge about the interactions of biomaterials with biological matrices is still poor however crucial to future development in terms of how to cope with immunomodulatory adverse effects and to control the integration of implants into tissue or the targeting of nano devices. The appropriate design of a material depends on reliable data about the influence of oligomer or polymer configuration and dispersity as well as surface properties including chemical modifications. This work addressed the interaction of four polylactide (PLA) resomers, a well-established, biodegradable biomaterial, and two physiologically relevant proteins, which are ubiquitous in human serum - albumin (HSA) and fibrinogen (HFG)...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28777502/carbon-nanomaterials-in-biological-studies-and-biomedicine
#18
REVIEW
Nagappa L Teradal, Raz Jelinek
The "carbon nano-world" has made over the past few decades huge contributions in diverse scientific disciplines and technological advances. While dramatic advances have been widely publicized in using carbon nanomaterials such as fullerenes, carbon nanotubes, and graphene in materials sciences, nano-electronics, and photonics, their contributions to biology and biomedicine have been noteworthy as well. This Review focuses on the use of carbon nanotubes (CNTs), graphene, and carbon quantum dots [encompassing graphene quantum dots (GQDs) and carbon dots (C-dots)] in biologically oriented materials and applications...
August 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28773174/hydrothermal-sterilization-improves-initial-osteoblast-responses-on-sandpaper-polished-titanium
#19
Xingling Shi, Lingli Xu, Qingliang Wang, Lin Xu
Hydrocarbon contamination accumulated on titanium (Ti) implant surfaces during storage and sterilization is unavoidable and difficult to remove. It impairs the bioactivity of implants, restricts initial interactions between implants and the surrounding biological environment, and has become a common challenge for Ti implants. To overcome this problem, sterilization was considered as the final surface modification and a novel method, hydrothermal sterilization (HS), was proposed. Briefly, stored sandpaper-polished Ti specimens were sterilized in a glass container with pure water at 121 °C for 20 min and kept in the same water until utilization...
July 17, 2017: Materials
https://www.readbyqxmd.com/read/28772861/calcium-silicate-chitosan-coated-electrospun-poly-lactic-acid-fibers-for-bone-tissue-engineering
#20
Chu-Jung Su, Ming-Gene Tu, Li-Ju Wei, Tuan-Ti Hsu, Chia-Tze Kao, Tsui-Han Chen, Tsui-Hsien Huang
Electrospinning technology allows fabrication of nano- or microfibrous fibers with inorganic and organic matrix and it is widely applied in bone tissue engineering as it allows precise control over the shapes and structures of the fibers. Natural bone has an ordered composition of organic fibers with dispersion of inorganic apatite among them. In this study, poly (lactic acid) (PLA) mats were fabricated with electrospinning and coated with chitosan (CH)/calcium silicate (CS) mixer. The microstructure, chemical component, and contact angle of CS/CH-PLA composites were analyzed by scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy...
May 5, 2017: Materials
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