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https://www.readbyqxmd.com/read/28642502/quasi-stabilized-hydration-layers-on-muscovite-mica-under-a-thin-water-film-grown-from-humid-air
#1
Toyoko Arai, Kohei Sato, Asuka Iida, Masahiko Tomitori
The interfaces between solids and water films in air play fundamental roles in physicochemical phenomena, biological functions, and nano-fabrication. Though the properties of the interfaces have been considered to be irrelevant to the water film thickness, we found distinctive mechanical features of the interface between a cleaved muscovite mica surface and a thin water film grown in humid air, dissimilar to those in bulk water, using frequency-modulation atomic force microscopy. The thin water film grew with quasi-stabilized hydration networks of water molecules, tightly bound each other at the interface, to a thickness of ~2 nm at near-saturating humidity...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28640580/a-bio-inspired-alginate-gum-arabic-hydrogel-with-micro-nano-scale-structures-for-controlled-drug-release-in-chronic-wound-healing
#2
Mi Li, Haichang Li, Xiangguang Li, Hua Zhu, Zihui Xu, Lianqing Liu, Jianjie Ma, Mingjun Zhang
Bio-polymeric hydrogels have drawn increasingly research interests in biomaterials due to its tunable physical and chemical properties for both creating bioactive cellular micro-environment and serving as sustainable therapeutic reagents. Inspired by a naturally occurring hydrogel secreted from the carnivorous Sundew plant for trapping insects, here we have developed a bio-inspired hydrogel to deliver mitsugumin53 (MG53), an important protein in cell membrane repair, for chronic wound healing. Both chemical compositions and micro/nano morphological properties inherent from the natural Sundew hydrogel were mimicked using sodium alginate and gum arabic with calcium ion-mediated cross-linking...
June 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28633520/ion-selective-nanosensor-for-photoacoustic-and-fluorescence-imaging-of-potassium
#3
Chang Heon Lee, Jeff Folz, Wuliang Zhang, Janggun Jo, Joel W Y Tan, Xueding Wang, Raoul Kopelman
Ion-selective optodes (ISOs), the optical analog of ion-selective electrodes, have played an increasingly important role in chemical and biochemical analysis. Here we extend this technique to ion-selective photo-acoustic optodes (ISPAOs) that serve at the same time as fluorescence-based ISOs, and apply it specifically to potassium (K+). Notably, the potassium ion is one of the most abundant cations in biological systems, involved in numerous physiological and pathological processes. Furthermore, it has been recently reported that the presence of abnormal extracellular potassium concentrations in tumors suppresses the immune responses and thus suppresses immunotherapy...
June 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28631375/3d-mimicry-of-native-tissue-fiber-architecture-guides-tendon-derived-cells-and-adipose-stem-cells-into-artificial-tendon-constructs
#4
Mariana Laranjeira, Rui M A Domingues, Raquel Costa-Almeida, Rui L Reis, Manuela E Gomes
Tendon and ligament (T/L) function is intrinsically related with their unique hierarchically and anisotropically organized extracellular matrix. Their natural healing capacity is, however, limited. Here, continuous and aligned electrospun nanofiber threads (CANT) based on synthetic/natural polymer blends mechanically reinforced with cellulose nanocrystals are produced to replicate the nanoscale collagen fibrils grouped into microscale collagen fibers that compose the native T/L. CANT are then incrementally assembled into 3D hierarchical scaffolds, resulting in woven constructions, which simultaneously mimic T/L nano-to-macro architecture, nanotopography, and nonlinear biomechanical behavior...
June 20, 2017: Small
https://www.readbyqxmd.com/read/28630667/evaluation-of-radical-scavenging-system-in-amoeba-chaos-carolinense-during-nutrient-deprivation
#5
Yuru Deng, Edlyn Li-Hui Lee, Ketpin Chong, Zakaria A Almsherqi
The frequent appearance of non-lamellar membrane arrangements such as cubic membranes (CMs) in cells under stressed or pathological conditions points to an intrinsic cellular response mechanism. CM represents highly curved, three-dimensional nano-periodic structures that correspond to mathematically well-defined triply periodic minimal surfaces. Specifically, cellular membrane may transform into CM organization in response to pathological, inflammatory and oxidative stress conditions. CM organization, thus, may provide an advantage to cope with various types of stress...
August 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28629069/evaluation-of-electrospun-biomimetic-substrate-surface-decorated-with-nanohydroxyapatite-precipitation-for-osteoblasts-behavior
#6
Sai Zhang, Guojun Jiang, Molamma P Prabhakaran, Xiaohong Qin, Seeram Ramakrishna
To engineer bone tissue, it is crucial to design scaffolds with micro- and nano-sized architecture imitating approximate hierarchical structure of native bone, and afford desirable biological properties by introducing biocompatible polymers and bioceramics into the scaffolds. Here, a novel scaffold consisting of poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV)/polyaspartic acid (PAA) was fabricated by electrospinning and nano-hydroxyapatite (nHA) was deposited by calcium-phosphate dipping process for bone tissue regeneration...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629063/substitution-of-strontium-and-boron-into-hydroxyapatite-crystals-effect-on-physicochemical-properties-and-biocompatibility-with-human-wharton-jelly-stem-cells
#7
Joanna Kolmas, Frédéric Velard, Aneta Jaguszewska, Flora Lemaire, Halima Kerdjoudj, Sophie C Gangloff, Agnieszka Kaflak
Hydroxyapatite (HA) enriched with strontium and boron ions was synthesized using two different methods: the precipitation method (Sr,B-HAw) and the dry method (Sr,B-HAd). Additionally, for the sake of comparison, the "pure" unsubstituted HA was prepared together with HAs substituted only with one type of a foreign ion. The obtained materials were subjected to physicochemical analysis with the use of various analytical methods, such as powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), inductively coupled plasma optical emission spectroscopy (ICP-OES), Fourier transform infrared spectroscopy (FT-IR) and solid-state proton nuclear magnetic resonance ((1)H ssNMR)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628642/nanoscale-quantification-of-the-biophysical-characterization-of-combretastatin-a-4-treated-tumor-cells-using-atomic-force-microscopy
#8
Yanchun Li, Jv Chen, Yutong Liu, Weige Zhang, Wenhui He, Hanying Xu, Lianqing Liu, Enlong Ma
As an inhibitor of microtubule assembly, combretastatin A-4 (CA-4)-induced biological responses in tumor cells have been well known, but the corresponding changes in nano-biophysical properties were not investigated given the lack of an ideal tool. Using AFM technique, we investigated the alteration of nano-biophysical properties when CA-4-treated tumor cells underwent the different biological processes, including cell cycle arrest, apoptosis and autophagy. We found that CA-4-resistant cells were rougher with the presence of characteristic "ridges", indicating that the development of "ridge" structure may be a determinant of the sensitivity of cells to CA-4 compounds...
2017: PloS One
https://www.readbyqxmd.com/read/28626557/electrostatically-driven-resonance-energy-transfer-in-cationic-biocompatible-indium-phosphide-quantum-dots
#9
Gayathri Devatha, Soumendu Roy, Anish Rao, Abhik Mallick, Sudipta Basu, Pramod P Pillai
Indium Phosphide Quantum Dots (InP QDs) have emerged as an alternative to toxic metal ion based QDs in nanobiotechnology. The ability to generate cationic surface charge, without compromising stability and biocompatibility, is essential in realizing the full potential of InP QDs in biological applications. We have addressed this challenge by developing a place exchange protocol for the preparation of cationic InP/ZnS QDs. The quaternary ammonium group provides the much required permanent positive charge and stability to InP/ZnS QDs in biofluids...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28625688/electrically-atomised-formulations-of-timolol-maleate-for-direct-and-on-demand-ocular-lens-coatings
#10
Prina Mehta, Ali Al-Kinani, Rita Haj-Ahmad, Muhammad Sohail Arshad, Ming-Wei Chang, G Raid Alany, Zeeshan Ahmad
Advances in nanotechnology have enabled solutions for challenging drug delivery targets. While the eye presents numerous emerging opportunities for delivery, analysis and sensing; issues persist for conventional applications. This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms. The work presented here demonstrates a single needle electrohydrodynamic (EHD) engineering process to nano-coat (as an on demand and controllable fiber depositing method) the surface of multiple contact lenses rendering formulations to be stationary on the lens and at the bio-interface...
June 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28623699/the-effect-of-the-protein-corona-on-the-interaction-between-nanoparticles-and-lipid-bilayers
#11
Desirè Di Silvio, Marco Maccarini, Roger Parker, Alan Mackie, Giovanna Fragneto, Francesca Baldelli Bombelli
HYPOTHESIS: It is known that nanoparticles (NPs) in a biological fluid are immediately coated by a protein corona (PC), composed of a hard (strongly bounded) and a soft (loosely associated) layers, which represents the real nano-interface interacting with the cellular membrane in vivo. In this regard, supported lipid bilayers (SLB) have extensively been used as relevant model systems for elucidating the interaction between biomembranes and NPs. Herein we show how the presence of a PC on the NP surface changes the interaction between NPs and lipid bilayers with particular care on the effects induced by the NPs on the bilayer structure...
May 29, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28623694/monitoring-of-nanoclay-protein-adsorption-isotherms-via-fluorescence-techniques
#12
Tom Felbeck, Sebastian Moss, Alexandre M P Botas, Marina M Lezhnina, Rute A S Ferreira, Luís D Carlos, Ulrich H Kynast
The investigation of nanoparticles and their interaction with bio-macromolecules have become an important issue; the widely discussed protein corona around nanoparticles and their biological fate in general have drawn particular attention. Here, we focus on nanoclay dispersions and the use of solvatochromic fluorescent dyes (Dansyl and Coumarin 153) for monitoring the interaction with two model proteins, bovine serum albumin and β-lactoglobulin. On one hand, these dyes are poorly emissive in water, but experience a boost in their fluorescence when adsorbed into the hydrophobic domains of proteins...
June 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28623284/spatio-temporal-steering-for-testing-nonclassical-correlations-in-quantum-networks
#13
Shin-Liang Chen, Neill Lambert, Che-Ming Li, Guang-Yin Chen, Yueh-Nan Chen, Adam Miranowicz, Franco Nori
We introduce the concept of spatio-temporal steering (STS), which reduces, in special cases, to Einstein-Podolsky-Rosen steering and the recently-introduced temporal steering. We describe two measures of this effect referred to as the STS weight and robustness. We suggest that these STS measures enable a new way to assess nonclassical correlations in an open quantum network, such as quantum transport through nano-structures or excitation transfer in a complex biological system. As one of our examples, we apply STS to check nonclassical correlations among sites in a photosynthetic pigment-protein complex in the Fenna-Matthews-Olson model...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28621456/absorption-distribution-and-excretion-of-four-forms-of-titanium-dioxide-pigment-in-the-rat
#14
Thomas P Farrell, Berna Magnuson
Titanium dioxide (TiO2 ) is a white color additive that has a long history of global approval and use in food. There is, however, considerable confusion regarding the applicability of the biological effects of novel, engineered, nano-sized forms of TiO2 developed for nonpigmentary applications to the safety of oral exposure to food grade TiO2 pigment. The objective of this study was to assess the absorption, distribution, and routes of excretion in rats after oral exposure to food grade TiO2 . Four different grades of TiO2 (200 ppm) or control (0 ppm) diets were fed to rats for 7 consecutive days, followed by control diet only for 1, 24, or 72 h...
June 16, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28620669/linear-and-orthogonal-peptide-templating-of-silicified-protein-fibres
#15
Angelo Bella, Santanu Ray, Maxim G Ryadnov
Biomineralisation is essential for biology. Specialist proteins use peptide motifs that catalyse mineral deposition into nano-to-microscale inorganic materials. Unlike in native proteins, the motifs incorporated into self-assembled fibres can persistently propagate on the microscopic scale enabling empirically defined silica nanostructures. Herein we show that the two main modes of motif templating - linear and orthogonal - in self-assembling, fibre-forming peptide sequences effectively silicify protein fibres...
June 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28619648/biophysical-characterization-of-nanostructured-tio2-as-a-good-substrate-for-hbm-msc-adhesion-growth-and-differentiation
#16
L Petecchia, C Usai, M Vassalli, P Gavazzo
Mesenchymal stem cells from human bone marrow (hBM-MSC) are widely utilized for clinical applications involving bone healing. In this context, their use has been often optimized in association to variously designed titanium substrates, being this material of great use in orthopaedic implants. According to recent findings, the ability of hBM-MSC to differentiate towards a specific lineage is not only driven by biochemical signals, but physical stimuli, such as rigidity or roughness of the substrate, can also support a commitment towards osteogenic differentiation...
June 12, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28619003/hydroxyapatite-as-a-nanomaterial-for-advanced-tissue-engineering-and-drug-therapy
#17
Juha Tuukkanen, Miho Nakamura
Hydroxyapatite (HAp) is a complicated ceramic material that varies between the way it appears in biological systems and how it is synthesized as various calcium phosphates. HAp varies in chemical composition of substituting atoms, crystallinity, grain size and electrical polarization. HAp can form solid to macro-, micro- and nanoporous structures. Also, particulate HAp can have highly porous structure. HAp can be used as coatings for metal implants in thicknesses from hundreds of microns down to hundreds of nanometers...
June 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28618240/omics-for-precious-rare-biosamples-characterization-of-ancient-human-hair-by-a-proteomic-approach
#18
Margaux Fresnais, Pascale Richardin, Marcela Sepúlveda, Emmanuelle Leize-Wagner, Armelle Charrié-Duhaut
Omics technologies have far-reaching applications beyond clinical medicine. A case in point is the analysis of ancient hair samples. Indeed, hair is an important biological indicator that has become a material of choice in archeometry to study the ancient civilizations and their environment. Current characterization of ancient hair is based on elemental and structural analyses, but only few studies have focused on the molecular aspects of ancient hair proteins-keratins-and their conservation state. In such cases, applied extraction protocols require large amounts of raw hair, from 30 to 100 mg...
June 15, 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28618037/hydrogen-peroxide-stimulates-exosomal-cathepsin-b-regulation-of-the-receptor-for-advanced-glycation-end-products-rage
#19
Charles A Downs, Viet D Dang, Nicholle M Johnson, Nancy Denslow, Abdel A Alli
Exosomes are nano-sized vesicles that are secreted into the extracellular environment. These vesicles contain various biological effector molecules that can regulate intracellular signaling pathways in recipient cells. The aim of this study was to examine a correlation between exosomal cathepsin B activity and the receptor for advanced glycation end-products (RAGE). Type 1 alveolar epithelial (R3/1) cells were treated with or without hydrogen peroxide and exosomes isolated from the cell conditioned media were characterized by NanoSight analysis...
June 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28611604/on-the-accuracy-of-in-vivo-ethanol-and-acetaldehyde-monitoring-a-key-tile-in-the-puzzle-of-acetaldehyde-as-a-neuroactive-agent
#20
REVIEW
Paolo Enrico, Marco Diana
Over the last 20 years researchers have explored the postulated role of acetaldehyde (ACD) as a mediator of some of the actions of ethanol (EtOH) in the central nervous system (CNS). However, efforts have been hampered mainly by the difficulty of directly measuring in vivo EtOH and ACD levels in the CNS and thus, our knowledge is based on indirect evidences. Although technically challenging, the development of reliable methods for in vivo measurement of ACD and EtOH is of paramount importance to solve the "puzzle of acetaldehyde as a neuroactive agent...
2017: Frontiers in Behavioral Neuroscience
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