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https://www.readbyqxmd.com/read/28437614/engineering-highly-interconnected-neuronal-networks-on-nanowire-scaffolds
#1
Vini Gautam, Shagufta Naureen, Naeem Shahid, Qian Gao, Yi Wang, David R Nisbet, Chennupati Jagadish, Vincent R Daria
Identifying the specific role of physical guidance cues in the growth of neurons is crucial for understanding the fundamental biology of brain development and for designing scaffolds for tissue engineering. Here, we investigate the structural significance of nanoscale topographies as physical cues for neurite outgrowth and circuit formation by growing neurons on semiconductor nanowires. We monitored neurite growth using optical and scanning electron microscopy, and evaluated the spontaneous neuronal network activity using functional calcium imaging...
April 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28436920/hybrid-3d-printing-and-electrodeposition-approach-for-controllable-3d-alginate-hydrogel-formation
#2
Wanfeng Shang, Yanting Liu, Wenfeng Wan, Chengzhi Hu, Zeyang Liu, Chin To Wong, Toshio Fukuda, Yajing Shen
Calcium alginate hydrogel is one of the most widely used biocompatible materials in biomedical and tissue engineering. This paper reports a hybrid 3D printing and electrodeposition approach to form the 3D calcium alginate hydrogel in a controllable manner. Firstly, a specific 3D printing system is developed by combining a 3D printer and a customized ejection syringe. Then, the mixed solution (1% w/v sodium alginate and 0.25% w/v CaCO3 nano particles) is filled in the syringe and ejected out from the nozzle to the substrate continuously...
April 24, 2017: Biofabrication
https://www.readbyqxmd.com/read/28434999/smfret-experiments-of-the-rna-polymerase-ii-transcription-initiation-complex
#3
REVIEW
Nicole Malkusch, Thilo Dörfler, Julia Nagy, Tobias Eilert, Jens Michaelis
Single-molecule fluorescence and in particular single-molecule Förster Resonance Energy Transfer (smFRET(1)) is a powerful tool to provide real-time information on the dynamic architecture of large macromolecular structures such as eukaryotic transcription initiation complexes. In contrast to other structural biology methods, not only structural details, but dynamics transitions are revealed thus closing in on the underlying molecular mechanisms. Here, we describe a comprehensive quantitative biophysical toolbox which can be used for rigorous analysis of dynamic protein-nucleic acid complexes and is applied to the study of eukaryotic transcription initiation...
April 18, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28432315/experimental-evidence-of-fano-resonances-in-nanomechanical-resonators
#4
Stefano Stassi, Alessandro Chiadò, Giuseppe Calafiore, Gianluca Palmara, Stefano Cabrini, Carlo Ricciardi
Fano resonance refers to an interference between localized and continuum states that was firstly reported for atomic physics and solid-state quantum devices. In recent years, Fano interference gained more and more attention for its importance in metamaterials, nanoscale photonic devices, plasmonic nanoclusters and surface-enhanced Raman scattering (SERS). Despite such interest in nano-optics, no experimental evidence of Fano interference was reported up to now for purely nanomechanical resonators, even if classical mechanical analogies were referred from a theoretical point of view...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431297/nano-zirconia-evaluation-of-its-antioxidant-and-anticancer-activity
#5
Siripireddy Balaji, Badal Kumar Mandal, Shivendu Ranjan, Nandita Dasgupta, Ramalingam Chidambaram
Bioactivity of nanomaterials largely depends on its size, shape and crystalline nature. In this work, the smaller sized spherical shaped nano-zirconia (ZrO2 NPs) (of ~9 to 11nm) was fabricated and studied its biological activity especially antioxidant and cytotoxicity against human colon carcinoma (HCT-116) and human lung carcinoma (A-549) cell lines. To have its real applications in biological aspects readily available Eucalyptus globulus (E. globulus) leaf extract was used as an effective capping and reducing agent for its synthesis...
April 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28429028/experimental-separation-steps-influence-the-protein-content-of-corona-around-mesoporous-silica-nanoparticles
#6
C Pisani, J C Gaillard, C Dorandeu, C Charnay, Y Guari, J Chopineau, J M Devoisselle, J Armengaud, O Prat
In order to direct nanocarriers to their targets efficiently, we have to understand the interactions occurring at the nano-bio interface between nanocarriers and human proteins, which forms the layer called the corona. However, experiments aiming to identify and quantify the proteins in the corona, especially critical steps in the separation of nanoparticles from biological media may affect the corona composition. Here, we used nano-LC MS/MS to compare the protein corona contents obtained after using two different separation methods...
April 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28426935/manipulation-of-mg2-ca2-switch-on-the-development-of-bone-mimetic-hydroxyapatite
#7
Nancy C Andrés, Noelia L D'Elía, Juan M Ruso, Adrián Esteban Campelo, Virginia L Massheimer, Paula V Messina
Ionic substitution can affect essential physicochemical properties leading to a specific biological behavior upon implantation. Therefore it has been proposed as a tool to increase the biological efficiency of calcium phosphate based materials. In the following study we have evaluated the contribution of an important cation in nature, Mg2+, into the structure of previously studied biocompatible and biodegradable hydroxyapatite (HA) nano-rods and its subsequent effect on its chemical, morphology and bone mimetic articulation...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28425863/targeted-drug-delivery-based-on-gold-nanoparticle-derivatives
#8
Mazaher Gholipourmalekabadi, Mohammadmahdi Mobaraki, Maryam Ghaffari, Amir Zarebkohan, Vahid F Omrani, Aleksandra M Urbanska, Alexander Seifalian
Drug delivery systems are effective and attractive methods which allow therapeutic substances to be introduced into the body more effectively and safe by having tunable delivery rate and release target site. Gold nanoparticles (AuNPs) have a myriad of favorable physical, chemical, optical, thermal and biological properties that make them highly suitable candidates as non-toxic carriers for drug and gene delivery. The surface modifications of AuNPs profoundly improve their circulation, minimize aggregation rates, enhance attachment to therapeutic molecules and target agents due to their nano range size which further increases their ability to cross cell membranes and reduce overall cytotoxicity...
April 19, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28417924/novel-nano-therapeutic-approach-actively-targets-human-ovarian-cancer-stem-cells-after-xenograft-into-nude-mice
#9
Amoura Abou-ElNaga, Ghada Mutawa, Ibrahim M El-Sherbiny, Hassan Abd-ElGhaffar, Ahmed A Allam, Jamaan Ajarem, Shaker A Mousa
The power of tumorigenesis, chemo-resistance and metastasis in malignant ovarian tumors resides in a tiny population of cancer cells known as ovarian cancer stem cells (OCSCs). Developing nano-therapeutic targeting of OCSCs is considered a great challenge. The potential use of poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) was investigated as a drug delivery system for paclitaxel (PTX) against OCSCs in vitro and in vivo. PTX-loaded PLGA NPs were prepared by an emulsion solvent evaporation method, supported by incorporation of folic acid (FA) as the ligand...
April 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28415549/the-precursors-effects-on-biomimetic-hydroxyapatite-ceramic-powders
#10
Afife Binnaz Hazar Yoruç, Aysu Aydınoğlu
In this study, effects of the starting material on chemical, physical, and biological properties of biomimetic hydroxyapatite ceramic powders (BHA) were investigated. Characterization and chemical analysis of BHA powders were performed by using XRD, FT-IR, and ICP-AES. Microstructural features such as size and morphology of the resulting BHA powders were characterized by using BET, nano particle sizer, pycnometer, and SEM. Additionally, biological properties of the BHA ceramic powders were also investigated by using water-soluble tetrazolium salts test (WST-1)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415513/evaluation-of-radiolabeled-curcumin-loaded-solid-lipid-nanoparticles-usage-as-an-imaging-agent-in-liver-spleen-scintigraphy
#11
Arif Kursad Ayan, Ayse Yenilmez, Hayrettin Eroglu
Curcumin-loaded solid lipid nanoparticles (C-SLNs) were prepared using micro emulsion and ultrasonication methods in the first stage of this study to determine the role of C-SLN on liver-spleen scintigraphy. It was concluded that the curcumin that was encapsulated in solid lipid nanoparticles had a β' polymorph structure according to the X-ray diffraction (XRD) analysis. İt was concluded that these particles were at nano scale according to the laser diffraction (LD) analysis. Fourier transform infrared spectroscopy (FT-IR) analysis suggested an interaction between the curcumin and the solid lipid matrix, and the curcumin was loaded on the solid lipid nanoparticles...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415457/a-novel-nano-hydroxyapatite-pmma-hybrid-scaffolds-adopted-by-conjugated-thermal-induced-phase-separation-tips-and-wet-chemical-approach-analysis-of-its-mechanical-and-biological-properties
#12
Radha G, Balakumar S, Balaji Venkatesan, Elangovan Vellaichamy
In this study, we report the preparation of nano-hydroxyapatite (nHAp) incorporated poly(methyl methacrylate) (PMMA) scaffolds by conjugated thermal induced phase separation (TIPS) and wet-chemical approach, which essentially facilitates the enhancement of both mechanical as well as biological properties of the scaffolds. The dissolution of PMMA was accomplished by acetone (Ace scaffold), ethanol-water (E-W scaffold) and isopropanol-water (I-W scaffold) mixtures as solvents. The existence of nHAp in PMMA matrix was investigated systematically...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415435/developing-an-electrochemical-sensor-based-on-a-carbon-paste-electrode-modified-with-nano-composite-of-reduced-graphene-oxide-and-cufe2o4-nanoparticles-for-determination-of-hydrogen-peroxide
#13
Ali Benvidi, Mohammad Taghi Nafar, Shahriar Jahanbani, Marzieh Dehghan Tezerjani, Masoud Rezaeinasab, Sudabeh Dalirnasab
In this paper, a highly sensitive voltammetric sensor based on a carbon paste electrode with CuFe2O4 nanoparticle (RGO/CuFe2O4/CPE) was designed for determination of hydrogen peroxide (H2O2). The electrocatalytic reduction of H2O2 was examined using various techniques such as cyclic voltammetry (CV), chronoamperometry, amperometry and differential pulse voltammetry (DPV). CuFe2O4 nanoparticles were synthesized by co-precipitation method and characterized with scanning electron microscopy (SEM), Transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) techniques...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414961/interaction-between-bacterial-cell-membranes-and-nano-tio2-revealed-by-two-dimensional-ftir-correlation-spectroscopy-using-bacterial-ghost-as-a-model-cell-envelope
#14
Guocheng Huang, Tsz Wai Ng, Taicheng An, Guiying Li, Bo Wang, Dan Wu, Ho Yin Yip, Huijun Zhao, Po Keung Wong
The interaction between microorganisms and nanoparticles is a crucial step towards understanding the subsequent biological effect. In this study, the interaction between TiO2 nanoparticles and bacterial cell membrane was investigated by Two-dimensional Correlation Fourier Transformation Infrared spectroscopy (2D-FTIR-COS) using bacterial ghosts (BGs), which are non-living bacterial cell envelopes devoid of cytoplasm. The synchronous map of 2D-FTIR-COS results indicated that the functionalities in proteins of BGs preferentially interacted with TiO2 nanoparticles; whereas the interaction of TiO2 nanoparticles with characteristic functionality in polysaccharides (COH) and phospholipids (PO) were very weak or insensitive...
April 10, 2017: Water Research
https://www.readbyqxmd.com/read/28414159/in-vitro-toxicological-effects-of-zinc-containing-nanoparticles-with-different-physico-chemical-properties
#15
Oskari Uski, Tiina Torvela, Olli Sippula, Tommi Karhunen, Hanna Koponen, Sirpa Peräniemi, Pasi Jalava, Mikko Happo, Jorma Jokiniemi, Maija-Riitta Hirvonen, Anna Lähde
Nanomaterials (NM) exhibit novel physicochemical properties that determine their interaction with biological substrates and processes. Recent nano-technological advances are leading to wide usage of metallic nanoparticles (NPs) in various fields. However, the increasing use of NPs has led to their release into environment and the toxicity of NPs on human health has become a concern. Moreover, there are inadvertently generated metallic NPs which are formed during various human activities (e.g. metal processing and energy production)...
April 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28412552/copper-containing-mesoporous-bioactive-glass-nanoparticles-as-multifunctional-agent-for-bone-regeneration
#16
Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giogia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M González-Calbet, Livia Visai, Chiara Vitale-Brovarone
The application of mesoporous bioactive glasses (MBGs) containing controllable amount of different ions, with the aim to impart antibacterial activity, as well as stimulation of osteogenesis and angiogenesis, is attracting an increasing interest. In this contribution, in order to endow nano-sized MBG with additional biological functions, the framework of a binary SiO2-CaO mesoporous glass was modified with different concentrations of copper ions (2 and 5% mol.), through a one-pot ultrasound-assisted sol-gel procedure...
April 12, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28411809/temperature-sensing-and-bio-imaging-applications-based-on-polyethylenimine-caf2-nanoparticles-with-upconversion-fluorescence
#17
Guofeng Liu, Zhen Sun, Zuoling Fu, Li Ma, Xiaojun Wang
Rare earth ion-doped upconversion nanoparticles (UCNPs) have become a research hotspot for their applications such as nano-thermometry and bio-imaging. Here we report one pot solvothermal synthesis of polyethylenimine (PEI) coated CaF2: 1%Er(3+), 2%Yb(3+) UCNPs with good water-solubility and biocompatibility. The nanoparticles show a spherical shape with an average size of 40nm and display intense green light (Yb(3+) and Er(3+)) under the 980nm irradiation. The maximum sensitivity of temperature sensing in the biological temperature range is obtained to be 0...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411808/validation-of-a-new-method-by-nano-liquid-chromatography-on-chip-tandem-mass-spectrometry-for-combined-quantitation-of-c3f-and-the-v65-vitronectin-fragment-as-biomarkers-of-diagnosis-and-severity-of-osteoarthritis
#18
Gaël Cobraiville, Marianne Fillet, Mohammed Sharif, Khadija Ourradi, Gwenaël Nys, Michel G Malaise, Dominique de Seny
Microfluidic liquid chromatography coupled to a nanoelectrospray source ion trap mass spectrometry was used for the absolute and simultaneous quantitation of C3f and the V65 vitronectin fragment in serum. The method was first carefully optimized and then validated in serum biological matrix. Stable isotopes for the two biomarkers of interest were used as stable isotope labeled peptide standards. A weighted 1/x(2) quadratic regression for C3f and a weighted 1/x quadratic regression for the V65 vitronectin peptide were selected for calibration curves...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411646/nano-armoring-of-enzymes-rational-design-of-polymer-wrapped-enzymes
#19
Kishore Raghupathi, Sankaran Thayumanavan
The formulation in which therapeutic proteins are administered plays a key role in retaining their biological activity. Enzyme wrapping, using synthetic polymers, is a strategy employed to provide enzymes with lower immunogenicity, longer circulation times, and better targeting capabilities. Protein-polymer complexation methods, involving covalent, noncovalent, and electrostatic interactions, that can provide means to develop formulations for retaining enzyme stability are discussed in this chapter. Amphiphilic self-cross-linkable polymer was used to encapsulate capsase-3 enzyme in the nanogel, while inverse emulsion polymerization method was used to entrap α-glucosidase enzyme in the nanogel...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28411510/compressed-sensing-for-stem-tomography
#20
Laurène Donati, Masih Nilchian, Sylvain Trépout, Cédric Messaoudi, Sergio Marco, Michael Unser
A central challenge in scanning transmission electron microscopy (STEM) is to reduce the electron radiation dosage required for accurate imaging of 3D biological nano-structures. Methods that permit tomographic reconstruction from a reduced number of STEM acquisitions without introducing significant degradation in the final volume are thus of particular importance. In random-beam STEM (RB-STEM), the projection measurements are acquired by randomly scanning a subset of pixels at every tilt view. In this work, we present a tailored RB-STEM acquisition-reconstruction framework that fully exploits the compressed sensing principles...
April 6, 2017: Ultramicroscopy
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