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https://www.readbyqxmd.com/read/29137278/comprehensive-microrna-sequencing-of-exosomes-derived-from-head-and-neck-carcinoma-cells-in-vitro-reveals-common-secretion-profiles-and-potential-utility-as-salivary-biomarkers
#1
Scott Langevin, Damaris Kuhnell, Tess Parry, Jacek Biesiada, Shouxiong Huang, Trisha Wise-Draper, Keith Casper, Xiang Zhang, Mario Medvedovic, Susan Kasper
Exosomes are nano-scale, membrane encapsulated vesicles that are released by cells into the extracellular space and function as intercellular signaling vectors through horizontal transfer of biologic molecules, including microRNA (miRNA). There is evidence that cancer-derived exosomes enable the tumor to manipulate its microenvironment, thus contributing to the capacity of the tumor for immune evasion, growth, invasion, and metastatic spread. The objective of this study was to characterize differential secretion of exosomal miRNA by head and neck squamous cell carcinoma (HNSCC) and identify a set of candidate biomarkers that could be detected in non-invasive saliva samples...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136946/neuroprotective-effect-of-hesperetin-and-nano-hesperetin-on-recognition-memory-impairment-and-the-elevated-oxygen-stress-in-rat-model-of-alzheimer-s-disease
#2
Elham Kheradmand, Akbar Hajizadeh Moghaddam, Mahboobeh Zare
Alzheimer disease (AD) is a progressive dementia affecting a large proportion of the aging population. There is evidence that brain tissue in patients with AD is exposed to oxidative stress during the course of the disease. Hesperetin (Hst) is a natural flavonoid, which has been reported to exert various biological activities such as antioxidant and anti-inflammatory effect. The present study aimed to investigate the effects of hesperetin and nano-hesperetin on neurobehavioral activity and superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRx) and catalase (CAT) enzymes activity, malondialdehyde (MDA) and glutathione (GSH) levels in hippocampal area of rats in an experimental model of AD...
November 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29131585/antibody-templated-assembly-of-an-rna-mimic-of-green-fluorescent-protein
#3
Alessandro Bertucci, Alessandro Porchetta, Francesco Ricci
One of the most intriguing ways through which Nature achieves regulation of biological pathways encompasses the coordination of non-covalent interactions that bring biomolecules to be co-localized in a designated restricted space. This nano-confinement leads to a drastic increase in the effective local concentration of the species involved, which ultimately triggers reactions that would otherwise not occur at the low concentrations found in cells. Inspired by this mechanism, we have explored the possibility of using antibodies as bivalent biomolecular substrates for the templated assembly of a functional RNA structure...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29127410/ultrafiltration-combined-with-size-exclusion-chromatography-efficiently-isolates-extracellular-vesicles-from-cell-culture-media-for-compositional-and-functional-studies
#4
Birke J Benedikter, Freek G Bouwman, Tanja Vajen, Alexandra C A Heinzmann, Gert Grauls, Edwin C Mariman, Emiel F M Wouters, Paul H Savelkoul, Carmen Lopez-Iglesias, Rory R Koenen, Gernot G U Rohde, Frank R M Stassen
Appropriate isolation methods are essential for unravelling the relative contribution of extracellular vesicles (EVs) and the EV-free secretome to homeostasis and disease. We hypothesized that ultrafiltration followed by size exclusion chromatography (UF-SEC) provides well-matched concentrates of EVs and free secreted molecules for proteomic and functional studies. Conditioned media of BEAS-2B bronchial epithelial cells were concentrated on 10 kDa centrifuge filters, followed by separation of EVs and free protein using sepharose CL-4B SEC...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127000/drug-delivery-systems-functionalized-with-bone-mineral-seeking-agents-for-bone-targeted-therapeutics
#5
REVIEW
S G Rotman, D W Grijpma, R G Richards, T F Moriarty, D Eglin, O Guillaume
The systemic administration of drugs to treat bone diseases is often associated with poor uptake of the drug in the targeted tissue, potential systemic toxicity and suboptimal efficacy. In order to overcome these limitations, many micro- and nano-sized drug carriers have been developed for the treatment of bone pathologies that exhibit specific affinity for bone. Drug carriers can be functionalized with bone mineral seekers (BMS), creating a targeted drug delivery system (DDS) which is able to bind to bone and release therapeutics directly at the site of interest...
November 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29123668/nanoehs-beyond-toxicity-focusing-on-biocorona
#6
Sijie Lin, Monika Mortimer, Ran Chen, Aleksandr Kakinen, Jim E Riviere, Thomas P Davis, Feng Ding, Pu Chun Ke
The first phase of environmental health and safety of nanomaterials (nanoEHS) studies has been mainly focused on evidence-based investigations that probe the impact of nanoparticles, nanomaterials and nano-enabled products on biological and ecological systems. The integration of multiple disciplines, including colloidal science, nanomaterial science, chemistry, toxicology/immunology and environmental science, is necessary to understand the implications of nanotechnology for both human health and the environment...
July 1, 2017: Environmental Science. Nano
https://www.readbyqxmd.com/read/29123531/chronic-obstructive-pulmonary-disease-derived-circulating-cells-release-il-18-and-il-33-under-ultrafine-particulate-matter-exposure-in-a-caspase-1-8-independent-manner
#7
Gianluigi De Falco, Chiara Colarusso, Michela Terlizzi, Ada Popolo, Michela Pecoraro, Mario Commodo, Patrizia Minutolo, Mariano Sirignano, Andrea D'Anna, Rita P Aquino, Aldo Pinto, Antonio Molino, Rosalinda Sorrentino
Chronic obstructive pulmonary disease (COPD) is considered the fourth-leading causes of death worldwide; COPD is caused by inhalation of noxious indoor and outdoor particles, especially cigarette smoke that represents the first risk factor for this respiratory disorder. To mimic the effects of particulate matter on COPD, we isolated peripheral blood mononuclear cells (PBMCs) and treated them with combustion-generated ultrafine particles (UFPs) obtained from two different fuel mixtures, namely, pure ethylene and a mixture of ethylene and dimethylfuran (the latter mimicking the combustion of biofuels)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29121461/nanomagnetic-system-for-rapid-diagnosis-of-acute-infection
#8
Ki Soo Park, Hoyoung Kim, Soojin Kim, Kyungheon Lee, Sohyeon Park, Jun Song, Changwook Min, Farhana Khanam, Rasheduzzaman Rashu, Taufiqur Rahman Bhuiyan, Edward T Ryan, Firdausi Qadri, Ralph Weissleder, Jinwoo Cheon, Richelle C Charles, Hakho Lee
Pathogen-activated antibody-secreting cells (ASCs) produce and secrete antigen-specific antibodies. ASCs are detectable in the peripheral blood as early as 3 days after antigen exposure, which makes ASCs a potential biomarker for early disease detection. Here, we present a magnetic capture and detection (MCD) assay for sensitive, on-site detection of ASCs. In this approach, ASCs are enriched through magnetic capture, and secreted antibodies are magnetically detected by a miniaturized nuclear magnetic resonance (μNMR) system...
November 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/29119943/an-appraisal-on-various-methods-of-nano-particulate-formulations
#9
Bindu Dhiman, Divtrannum Bhalla, Anju Dhiman, Sapna Saini
Nanotechnology has gained a great deal of public interest due to the needs and applications of nanomaterials in many areas of human endeavours such as industry, agriculture, business, medicine, public health amongst many others. Nanotechnology includes the integration of these nanoscale structures into larger material components and systems, keeping the control and construction of new and improved materials at the nanoscale. Biological nanoparticles are mainly developed for drug delivery systems as an alternative to liposomal technology, in order to overcome the problems related to the stability of these vesicles in biological fluids and during the storage...
November 8, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29115333/an-apolipoprotein-enriched-biomolecular-corona-switches-the-cellular-uptake-mechanism-and-trafficking-pathway-of-lipid-nanoparticles
#10
L Digiacomo, F Cardarelli, D Pozzi, S Palchetti, M A Digman, E Gratton, A L Capriotti, M Mahmoudi, G Caracciolo
Following exposure to biological milieus (e.g. after systemic administration), nanoparticles (NPs) get covered by an outer biomolecular corona (BC) that defines many of their biological outcomes, such as the elicited immune response, biodistribution, and targeting abilities. In spite of this, the role of BC in regulating the cellular uptake and the subcellular trafficking properties of NPs has remained elusive. Here, we tackle this issue by employing multicomponent (MC) lipid NPs, human plasma (HP) and HeLa cells as models for nanoformulations, biological fluids, and target cells, respectively...
November 8, 2017: Nanoscale
https://www.readbyqxmd.com/read/29110291/non-ionic-surfactant-based-in-situ-forming-vesicles-as-controlled-parenteral-delivery-systems
#11
Hussein O Ammar, Magdy Ibrahim, Azza A Mahmoud, Rehab N Shamma, Nada M El Hoffy
Non-ionic surfactant (NIS) based in situ forming vesicles (ISVs) present an affordable alternative to the traditional systems for the parenteral control of drug release. In this work, NIS based ISVs encapsulating tenoxicam were prepared using the emulsion method. Tenoxicam-loaded ISVs were prepared using a 2(2).3(1) full factorial experimental design, where three factors were evaluated as independent variables; type of NIS (A), molar ratio of NIS to Tween®80 (B), and phase ratio of the internal ethyl acetate to the external Captex® oil phase (C)...
November 6, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29104135/nonlocal-strain-gradient-beam-model-for-postbuckling-and-associated-vibrational-response-of-lipid-supramolecular-protein-micro-nano-tubules
#12
S Sahmani, M M Aghdam
As a supramolecular construction, lipid protein micro/nano-tubules can be utilized in a variety of sustained biological delivery system. The high slenderness ratio of lipid tubules makes their hierarchical assembly into a desired architecture difficult. Therefore, an accurate prediction of mechanical behavior of lipid tubular is essential. The objective of this study is to capture size dependency in the postbuckling and vibrational response of the postbuckled lipid micro/nano-tubules more comprehensively. To this purpose, the nonlocal strain gradient elasticity theory is incorporated to the third-order shear deformation beam theory to develop an unconventional beam model...
November 8, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/29101783/one-pot-preparation-of-hydrophilic-manganese-oxide-nanoparticles-as-t1-nano-contrast-agent-for-molecular-magnetic-resonance-imaging-of-renal-carcinoma-in-vitro-and-in-vivo
#13
Jingjing Li, Chen Wu, Pingfu Hou, Min Zhang, Kai Xu
Magnetic resonance imaging (MRI) contrast agents have become a necessary part for clinical practice to improve the sensitivity for the diagnosis of small lesions and injuries. Among them, manganese oxide nanoparticle (MnO NPs)-based MRI contrast agent attracts more and more attention because of their better performance in the detection of brain disease and positive enhancement in T1-weighted image. However, the relatively low r1 relaxivity and complex synthetic route hampered their wider applications. In this work, we proposed a one-pot approach to prepare hydrophilic MnO NPs via a polyol-like method with poly (ethylene glycol) (PEG) as both a solvent and surfactant...
October 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29098339/a-biomimetic-approach-to-conjugate-vitamin-b6-cofactor-with-the-lysozyme-cocooned-fluorescent-auncs-and-its-application-in-turn-on-sensing-of-zinc-ii-in-environmental-and-biological-samples
#14
Shilpa Bothra, Lavanya Thilak Babu, Priyankar Paira, S K Ashok Kumar, Rajender Kumar, Suban K Sahoo
This communication focusses on the synthesis of red fluorescent lysozyme cocooned gold nanoclusters (Lyso-AuNCs) that have been successfully applied for the selective and specific recognition of the vitamin B6 cofactor pyridoxal-5'-phosphate (PLP). The red fluorescence of Lyso-AuNCs showed remarkable color change to yellow upon conjugation with PLP due to the formation of a Schiff base between the free -NH2 present in the lysozyme and the -CHO group of PLP. The developed PLP conjugated Lyso-AuNCs (PLP_Lyso-AuNCs) was applied for the selective turn-on recognition of Zn(2+) ions in aqueous medium...
November 2, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29096262/co-exposure-to-titanium-dioxide-nanoparticles-does-not-affect-cadmium-toxicity-in-radish-seeds-raphanus-sativus
#15
R Roshan Manesh, G Grassi, E Bergami, L F Marques-Santos, C Faleri, G Liberatori, I Corsi
Recent developments on environmental fate models indicate that as nano waste, engineered nanomaterials (ENMs) could reach terrestrial ecosystems thus potentially affecting environmental and human health. Plants can be therefore exposed to ENMs but controversial data in terms of fate and toxicity are currently available. Furthermore, there is a current lack of information on complex interactions/transformations to which ENMs undergo in the natural environment as for instance interacting with existing toxic compounds...
October 30, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29096071/molecular-neuroscience-in-the-21-st-century-a-personal-perspective
#16
REVIEW
Thomas C Südhof
Neuroscience is inherently interdisciplinary in its quest to explain the brain. Like all biological structures, the brain operates at multiple levels, from nano-scale molecules to meter-scale systems. Here, I argue that understanding the nano-scale organization of the brain is not only helpful for insight into its function, but is a requisite for such insight. I propose that one impediment to a better understanding of the brain is that most of its molecular processes are incompletely understood, and suggest a number of key questions that require our attention so that progress can be achieved in neuroscience beyond a description of the activity of neural circuits...
November 1, 2017: Neuron
https://www.readbyqxmd.com/read/29095664/graphene-based-scaffolds-on-bone-tissue-engineering
#17
Nasrin Shadjou, Mohammad Hasanzadeh, Balal Khalilzadeh
Tissue engineering has been emerging as a valid approach to the current therapies for bone regeneration/substitution. Tissue-engineered bone constructs have the potential to alleviate the demand arising from the shortage of suitable autograft and allograft materials for augmenting bone healing. Scaffolds play a central role in tissue engineering research, they not only provide as structural support for specific cells but also provide as the templates to guide new tissue growth and construction. In this survey we describe application of graphene based nano-biomaterials for bone tissue engineering...
November 2, 2017: Bioengineered
https://www.readbyqxmd.com/read/29090936/new-insights-on-the-structure-of-electrochemically-deposited-lithium-metal-and-its-solid-electrolyte-interphases-via-cryogenic-tem
#18
Xuefeng Wang, Minghao Zhang, Judith Alvarado, Shen Wang, Mahsa Sina, Bingyu Lu, James Bouwer, Wu Xu, Jie Xiao, Ji-Guang Zhang, Jun Liu, Ying Shirley Meng
Lithium metal has been considered the "holy grail" anode material for rechargeable batteries despite the fact that its dendritic growth and low Coulombic efficiency (CE) have crippled its practical use for decades. Its high chemical reactivity and low stability make it difficult to explore the intrinsic chemical and physical properties of the electrochemically deposited lithium (EDLi) and its accompanying solid electrolyte interphase (SEI). To prevent the dendritic growth and enhance the electrochemical reversibility, it is crucial to understand the nano- and mesostructures of EDLi...
November 2, 2017: Nano Letters
https://www.readbyqxmd.com/read/29088978/the-biological-challenges-and-pharmacological-opportunities-of-orally-administered-nanomedicine-delivery
#19
Darren Michael Moss, Paul Curley, Hannah Kinvig, Clare Hoskins, Andrew Owen
Nano-scale formulations are being developed to improve the delivery of orally administered medicines, and the interactions between nanoformulations and the gastrointestinal luminal, mucosal and epithelial environment is currently being investigated. The mucosal surface of the gastrointestinal tract is capable of trapping and eliminating large particles and pathogens as part of the natural defences of the body, it is becoming clearer that nanoformulation properties such as particle size, charge, and shape, as well as mucous properties such as viscoelasticity, thickness, density, and turn-over time are all relevant to these interactions...
November 1, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29080534/manipulation-and-separation-of-oil-droplets-by-using-asymmetric-nano-orifice-induced-dc-dielectrophoretic-method
#20
Kai Zhao, Dongqing Li
HYPOTHESIS: Emulsion droplets are versatile tools in chemical and biological fields and the separation of emulsion droplets is one of the most crucial steps in research and industry. EXPERIMENTS: This work developed a nano-orifice based DC dielectrophoretic (DEP) system for the sorting of oil-in-water emulsion droplets by size and content in a microchannel. Then, the size-dependent separation of oil droplets was conducted and verified by the prediction of theoretical simulation...
October 20, 2017: Journal of Colloid and Interface Science
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