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https://www.readbyqxmd.com/read/28719744/high-resolution-insights-into-the-stepwise-self-assembly-of-nanofiber-from-bioactive-peptides
#1
Fude Sun, Long Chen, Xiufang Ding, Lida Xu, Xirui Zhou, Peng Wei, Jun-Feng Liang, Shi-Zhong Luo
Peptide self-assembly has a profound biological significance since self-assembled bioactive peptides are gifted with improved bioactivity as well as life-span. In this study, peptide self-assembly was investigated using a therapeutic peptide, PTP-7S (EENFLGALFKALSKLL). Combining experiments of atomic force microscopy (AFM), circular dichroism (CD) and 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence spectra, PTP-7S showing α-helix was found self-assembling into nanofibers in solution. Relying on the coarse-grained (CG) dynamic simulations, the self-assembling of PTP-7S was revealed as a stepwise process that peptide monomers first clustered into peptide-assembling units (PUs) with charged surface, and then the PUs integrated together to construct nano-fibril aggregates...
July 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28719214/tunable-liquid-resistant-tip-enhanced-raman-spectroscopy-probes-towards-label-free-nano-resolved-imaging-of-biological-systems
#2
Jacob D Scherger, Mark David Foster
Tip enhanced Raman spectroscopy (TERS) has been established as a powerful, non-invasive technique for chemical identification at the nano-scale. However, difficulties, including the degradation of probes, limit its use in liquid systems. Here TERS probes for studies in aqueous environments have been demonstrated using Titanium Nitride coatings with an alumina protective layer. The probes show enhancement in signal intensity as high as 380% in liquid measurements and the probe resonance can be tuned by varying deposition conditions to optimize performance for different laser sources and types of samples...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28718777/an-assembly-and-interaction-of-upconversion-and-plasmonic-nanoparticles-on-organometallic-nanofibers-enhanced-multicolor-upconversion-downshifting-emission-and-plasmonic-effect
#3
Priyam Singh, Praveen Kumar Shahi, Rajiv Prakash, S B Rai
We herein present a novel inorganic-organic hybrid nanoparticle (HNPs) constituted of inorganic NPs, NaY0.78Er0.02Yb0.2F4, and organometallic nanofiber, Tb(ASA)3Phen (TAP). The X-ray diffraction, Fourier transform infrared absorption and TEM analyse reveal that, the prepared ultrafine upconversion nanoparticles {UCNPs (6-9 nm)} are dispersed on the surface of TAP nanofibers. We observe that addition of TAP in UCNPs, effectively prevents the surface quenching to boost the UC intensity and enables tuning of UC emission from green to red region by controlling the phonon frequency around Er3+ ion...
July 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28717157/cellular-uptake-pathways-of-sepiolite-nanofibers-and-dna-transfection-improvement
#4
Fidel Antonio Castro-Smirnov, Jeanne Ayache, Jean-Rémi Bertrand, Elodie Dardillac, Eric Le Cam, Olivier Piétrement, Pilar Aranda, Eduardo Ruiz-Hitzky, Bernard S Lopez
Sepiolite is a nanofibrous natural silicate that can be used as a nanocarrier because it can be naturally internalized into mammalian cells, due to its nano-size dimension. Therefore, deciphering the mechanisms of sepiolite cell internalization constitutes a question interesting biotechnology, for the use of sepiolite as nanocarrier, as well as environmental and public health concerns. Though it is low, the perfectly stable and natural intrinsic fluorescence of sepiolite nanofibers allows to follow their fate into cells by specifically sensitive technics...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28714577/direct-laser-interference-patterning-of-cocr-alloy-surfaces-to-control-endothelial-cell-and-platelet-response-for-cardiovascular-applications
#5
Romain Schieber, Federico Lasserre, Michael Hans, Marc Fernández-Yagüe, Maribel Díaz-Ricart, Ginés Escolar, Maria-Pau Ginebra, Frank Mücklich, Marta Pegueroles
The main drawbacks of cardiovascular bare-metal stents (BMS) are in-stent restenosis and stent thrombosis as a result of an incomplete endothelialization after stent implantation. Nano- and microscale modification of implant surfaces is a strategy to recover the functionality of the artery by stimulating and guiding molecular and biological processes at the implant/tissue interface. In this study, cobalt-chromium (CoCr) alloy surfaces are modified via direct laser interference patterning (DLIP) in order to create linear patterning onto CoCr surfaces with different periodicities (≈3, 10, 20, and 32 µm) and depths (≈20 and 800 nm)...
July 17, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28714408/biomaterials-and-supercritical-fluid-technologies-which-perspectives-to-fabricate-artificial-extracellular-matrix
#6
Della Porta Giovanna, E Reverchon, N Maffulli
The foundation of tissue engineering for either therapeutic or diagnostic applications is the ability to exploit living cells. Tissue engineering utilizes living cells as engineering materials implanted, seeded or bio-plotted into an artificial structure capable of supporting three-dimensional tissue formation. These structures, typically called scaffolds, are critical, both ex vivo and in vivo, to influence their own microenvironments. Scaffolds can serve the following purposes: allow cell attachment and migration, deliver and retain cells and biochemical factors, enable diffusion of vital cell nutrients or expressed products, exert certain mechanical and biological influences to modify the behaviour of the cell phase...
July 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28712005/an-overview-of-the-ongoing-insights-in-selenium-research-and-its-role-in-fish-nutrition-and-fish-health
#7
REVIEW
Kifayat Ullah Khan, Amina Zuberi, João Batista Kochenborger Fernandes, Imdad Ullah, Huda Sarwar
In the present review, the ongoing researches about selenium research in fish nutrition have been comprehensively discussed. Selenium research is getting popularity in fish nutrition as it is required for the normal growth and proper physiological and biochemical functions in fish. Its deficiency or surplus amounts create severe problems in fish. It is available as inorganic form, organic form, and nano form. In fish, most of the previous research is about the selenium requirements for fish by using only one selenium source mainly the inorganic one...
July 15, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28709896/comparative-study-on-antifungal-activities-of-chitosan-nanoparticles-and-chitosan-silver-nano-composites-against-fusarium-oxysporum-species-complex
#8
S H S Dananjaya, W K C U Erandani, Cheol-Hee Kim, Chamilani Nikapitiya, Jehee Lee, Mahanama De Zoysa
Though the metal nanoparticles (NPs) have been shown favorable results against fungal diseases, erratic environmental toxicity of NPs have raised serious concerns against their applications. Hence, it is vital to modify antifungal compounds into safe substitutes over synthetic chemicals. In this study, antifungal effects of chitosan nanoparticles (CNPs) and chitosan silver nanocomposites (CAgNCs) were compared against Fusarium oxysporum species complex. CNPs and CAgNCs were synthesized, characterized and compared based on the transmission electron microscope, X-ray diffraction, UV-vis absorbance spectra, particle size distribution, zeta potential and thermal stability analysis...
July 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28707589/advances-in-the-anticancer-value-of-the-ursolic-acid-through-nanodelivery
#9
Azadeh Manayi, Marjan Nikan, Navid Nobakht Haghighid, Mohammad Abdollahi
Ursolic acid, a natural pentacyclic triterpenoid is commonly found in plants and foods with promising biological and pharmacological activities. The compound has been under the attention of researchers due to its considerable anticancer effects through suppression of differentiation, angiogenesis, invasion, and metastasis of tumor cells via different pathways with low toxicity. Bioavailability of ursolic acid is poor due to poor solubility of the compound in water. Low bioavailability and short plasma half-life of ursolic acid along with non-specific distribution in the body are considered as impediments in the therapeutic development of the compound...
July 13, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28706243/target-guided-synthesis-using-dna-nano-templates-for-selectively-assembling-a-g-quadruplex-binding-c-myc-inhibitor
#10
Deepanjan Panda, Puja Saha, Tania Das, Jyotirmayee Dash
The development of small molecules is essential to modulate the cellular functions of biological targets in living system. Target Guided Synthesis (TGS) approaches have been used for the identification of potent small molecules for biological targets. We herein demonstrate an innovative example of TGS using DNA nano-templates that promote Huisgen cycloaddition from an array of azide and alkyne fragments. A G-quadruplex and a control duplex DNA nano-template have been prepared by assembling the DNA structures on gold-coated magnetic nanoparticles...
July 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28699627/nano-palladium-is-a-cellular-catalyst-for-in-vivo-chemistry
#11
Miles A Miller, Bjorn Askevold, Hannes Mikula, Rainer H Kohler, David Pirovich, Ralph Weissleder
Palladium catalysts have been widely adopted for organic synthesis and diverse industrial applications given their efficacy and safety, yet their biological in vivo use has been limited to date. Here we show that nanoencapsulated palladium is an effective means to target and treat disease through in vivo catalysis. Palladium nanoparticles (Pd-NPs) were created by screening different Pd compounds and then encapsulating bis[tri(2-furyl)phosphine]palladium(II) dichloride in a biocompatible poly(lactic-co-glycolic acid)-b-polyethyleneglycol platform...
July 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28696660/transient-nanoscopic-phase-separation-in-biological-lipid-membranes-resolved-by-planar-plasmonic-antennas
#12
Pamina Martina Winkler, Raju Regmi, Valentin Flauraud, Juergen Brugger, Herve Rigneault, Jerome Wenger, Maria F Garcia-Parajo
Nanoscale membrane assemblies of sphingolipids, cholesterol and certain proteins, also known as lipid rafts, play a crucial role in facilitating a broad range of important cell functions. Whereas on living cell membranes lipid rafts have been postulated to have nanoscopic dimensions and being highly transient, the existence of a similar type of dynamic nanodomains in multicomponent lipid bilayers has been questioned. Here, we perform fluorescence correlation spectroscopy on planar plasmonic antenna arrays with different nanogap sizes to assess the dynamic nanoscale organization of mimetic biological membranes...
July 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28691477/surface-modification-of-titanium-alloys-for-biomedical-application-from-macro-to-nano-scale
#13
D Pedreira De Oliveira, L Ottria, M Gargari, V Candotto, F J Silvestre, D Lauritano
Bone is a complexly structured tissue and hierarchically organized from macro to nano levels of dimensions. Biomaterial devices developed to replace and interact with bone tissues have been designed from the macro to nano perspective to provide suitable performance in acquiring primary and biological stability. Macro level designed features provide mechanical interlock and primary stability to implants inside the bone. Surface micro and nano structures influence cells behavior to promote the secondary or biological stability, reaching successful osseointegration...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28686901/noncalssical-multiscale-modeling-of-ssdna-manipulation-using-a-cnt-nanocarrier-based-on-afm
#14
M H Korayem, M Estaji, A Homayooni
Nanocarriers are useful tools in biological and medical research fields. In nanomanipulation, a nondestructive and successful process can be achieved by using nanocarriers. In this paper, a nonclassical multiscale approach has been presented for modeling a single strand DNA (ssDNA) manipulation based on AFM. To achieve a nondestructive nanomanipulation process, carbon nanotube (CNT) has been used as a nanocarrier. AFM setup has been separated into a Micro field (MF) and a Nano field (NF). The governing equations of the MF have been derived based on Kirchhoff plate model and a modified couple stress theory...
June 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28684089/quantitative-analysis-of-the-tumor-suppressor-dendrogenin-a-using-liquid-chromatography-tandem-mass-spectrometry
#15
Emmanuel Noguer, Régis Soules, Claude Netter, Citra Nagarathinam, Julie Leignadier, Emilie Huc-Claustre, Nizar Serhan, Arnaud Rives, Philippe de Medina, Sandrine Silvente-Poirot, Marc Poirot
Dendrogenin A (DDA) was recently identified as a mammalian cholesterol metabolite that displays tumor suppressor and neurostimulating properties at low doses. In breast tumors, DDA levels were found to be decreased compared to normal tissues, evidencing a metabolic deregulation of DDA production in cancers. DDA is an amino-oxysterol that contains three protonatable nitrogen atoms. This makes it physico-chemically different from other oxysterols and it therefore requires specific analytical methods We have previously used a two-step method for the quantification of DDA in biological samples: 1) DDA purification from a Bligh and Dyer extract by RP-HPLC using a 250×4...
July 3, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28682058/revealing-the-cell-material-interface-with-nanometer-resolution-by-focused-ion-beam-scanning-electron-microscopy
#16
Francesca Santoro, Wenting Zhao, Lydia-Marie Joubert, Liting Duan, Jan Schnitker, Yoeri van de Burgt, Hsin-Ya Lou, Bofei Liu, Alberto Salleo, Lifeng Cui, Yi Cui, Bianxiao Cui
The interface between cells and non-biological surfaces regulates cell attachment, chronic tissue responses, and ultimately the success of medical implants or biosensors. Clinical and laboratory studies show that topological features of the surface profoundly influences cellular responses, e.g. titanium surfaces with nano- and microtopographical structures enhance osteoblast attachment and host-implant integration as compare to smooth surface. To understand how cells and tissues respond to different topological features, it is of critical importance to directly visualize the cell-materials interface at the relevant nanometer length scale...
July 6, 2017: ACS Nano
https://www.readbyqxmd.com/read/28678160/lipid-bilayer-membrane-in-a-silicon-based-micron-sized-cavity-accessed-by-atomic-force-microscopy-and-electrochemical-impedance-spectroscopy
#17
Muhammad Shuja Khan, Noura Sayed Dosoky, Darayas Patel, Jeffrey Weimer, John Dalton Williams
Supported lipid bilayers (SLBs) are widely used in biophysical research to probe the functionality of biological membranes and to provide diagnoses in high throughput drug screening. Formation of SLBs at below phase transition temperature (Tm) has applications in nano-medicine research where low temperature profiles are required. Herein, we report the successful production of SLBs at above-as well as below-the Tm of the lipids in an anisotropically etched, silicon-based micro-cavity. The Si-based cavity walls exhibit controlled temperature which assist in the quick and stable formation of lipid bilayer membranes...
July 5, 2017: Biosensors
https://www.readbyqxmd.com/read/28675220/mechanism-of-mechanically-induced-optoelectronic-and-spintronic-phase-transitions-in-1d-graphene-spirals-insight-into-the-role-of-interlayer-coupling
#18
Xiaodong Xu, Bingyi Liu, Wenyu Zhao, Yongyuan Jiang, Linhua Liu, Weiqi Li, Guiling Zhang, Wei Quan Tian
Graphene spirals (GSs), an emerging carbonic nano-material with a Riemann surface, demonstrate extraordinary topological electronic signatures: interlayer coupling similar to van der Waals (vdW) heterojunctions and intralayer coupling within the spiral conformation. Based on the state-of-the-art first-principles technique, the electronic properties of the periphery-modified GSs with geometry deformation are explored under axial strain. For all GSs, there emerges a remarkable phase transition from metal to semiconductor, due to the attenuation of interlayer "σ-bonds" reducing the interlayer tunneling probability for carriers...
July 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28673052/synthesis-of-electrical-conductive-silica-nanofiber-gold-nanoparticle-composite-by-laser-pulses-and-sputtering-technique
#19
Sarah Hamza, Anna Ignaszak, Amirkianoosh Kiani
Biocompatible-sensing materials hold an important role in biomedical applications where there is a need to translate biological responses into electrical signals. Increasing the biocompatibility of these sensing devices generally causes a reduction in the overall conductivity due to the processing techniques. Silicon is becoming a more feasible and available option for use in these applications due to its semiconductor properties and availability. When processed to be porous, it has shown promising biocompatibility; however, a reduction in its conductivity is caused by its oxidization...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28670454/post-nano-strategies-for-drug-delivery-multistage-porous-silicon-microvectors
#20
Alessandro Venuta, Joy Wolfram, Haifa Shen, Mauro Ferrari
Nanodelivery systems usually improve the biodistribution of drugs, leading to reduced side effects and enhanced therapeutic efficacy. However, only a small portion of the injected nanoparticle dose accumulates in pathological tissue. Challenges in drug delivery arise due to a multitude of transport obstacles in the body, including the endothelium, the extracellular matrix, and the cell membrane. In general, nanoparticles are designed to overcome only a few biological barriers, making them inadequate for localized drug delivery...
January 14, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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