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https://www.readbyqxmd.com/read/28212453/bone-morphogenetic-protein-2-hybridized-with-nano-anchored-oligonucleotides-on-titanium-implants-enhances-osteogenic-differentiation-in-vivo
#1
Florian Böhrnsen, Jennifer Rublack, Nelia Aeckerle, Anne Foerster, Bernd Schwenzer, Judith Reichert, Dieter Scharnweber, Henning Schliephake
PURPOSE: Previous in vitro studies have shown that DNA oligonucleotides (ODN) can be successfully used as anchor strands for the binding and retarded release of biologically active recombinant human bone morphogenetic protein 2 (rhBMP-2). The aim of the present study was to test the hypothesis that rhBMP-2 bound to the surface of titanium implants through hybridization with nano-anchored ODN strands is biologically active and can enhance the induction of osteogenic markers in peri-implant bone in vivo...
February 17, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28211299/comparison-of-biodistribution-profile-of-monoclonal-antibodies-nanoparticles-and-aptamers-in-rats-with-breast-cancer
#2
Cristal Cerqueira-Coutinho, Sotiris Missailidis, Jéssica Alessandra-Perini, Daniel Escorsim Machado, Jamila Alessandra Perini, Ralph Santos-Oliveira
The use of monoclonal antibodies and aptamers is growing every single day, as the use of nanoparticle systems. Although most of the products are under investigation, there are a few commercialized products available at the market, for human consume. In this study, we have compared three formulations (aptamer anti-MUC1, monoclonal antibody - Trastuzumab and monoclonal antibodies nanoparticles - PLA/PVA/MMT trastuzumab) to identify their profile as also to understand their behavior into an alive biological system...
May 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28208189/advances-in-silver-nanotechnology-an-update-on-biomedical-applications-and-future-perspectives
#3
Shiva Gholizadeh-Ghaleh Aziz, Sara Gholizadeh-Ghaleh Aziz, Abolfazl Akbarzadeh
Nanotechnology is one of the most promising fields for producing new applications in nanotechnology, biotechnology, and medicine. However, only a few products have been used for nanotechnology, biotechnology, and medical purposes. Nanoparticles have been among the most usually applied nanomaterial in our health care system for hundreds of years. The most prominent nano product is nano silver which generally present at 1-100 nm in size in at least one dimension. Silver nanoparticles reveal remarkably unusual chemical, physical and biological properties and have been used for many different applications which detailed in this review...
February 16, 2017: Drug Research
https://www.readbyqxmd.com/read/28203002/-role-of-different-scale-structures-of-titanium-implant-in-the-biological-behaviors-of-human-umbilical-vein-endothelial-cells
#4
N W Liang, L Shi, Y Huang, X L Deng
OBJECTIVE: To study the role of different scale structure of Ti implants on the biological behaviors of human umbilical vein endothelial cell (HUVECs) and to reveal the role of material surface topographical features on peri-implant angiogenesis. METHODS: Titanium (Ti) discs with different surface structures (Ti discs with smooth surface, Ti discs with nano scale structure, Ti discs with micro scale structure and Ti discs with micro/nano scale structure, named as SM-Ti, Nano-Ti, Micro-Ti and Micro/Nano-Ti, respectively) were prepared and their surface topographical features were confirmed via scanning electron microscopy (SEM) observation...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28193357/efficient-and-clean-pre-concentration-of-ultra-trace-calcium-channel-blockers-from-biological-matrices-via-a-hyphenated-procedure-of-two-sequential-dispersive-solid-liquid-phase-microextractions
#5
Maryam Hemmati, Maryam Rajabi, Alireza Asghari
In the present work, we propose a safe, simple, and relatively rapid procedure for the efficient clean-up and pre-concentration of ultra-trace calcium channel blockers (CCBs) from the human plasma and urine samples followed by high performance liquid chromatography-ultraviolet detection. The proposed sample preparation method is a combination of two microextraction methods termed as ultrasound-assisted dispersive micro solid-phase extraction coupled with air-agitated liquid-liquid microextraction based on solidification of a floating organic droplet (UA-dμSPE-AA-LLME-SFO)...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28192956/multicolor-gold-silver-nano-mushrooms-as-ready-to-use-sers-probes-for-ultrasensitive-and-multiplex-dna-mirna-detection
#6
Jing Su, Dongfang Wang, Lena Nörbel, Jianlei Shen, Zhihan Zhao, Yanzhi Dou, Tianhuan Peng, Jiye Shi, Sanjay Mathur, Chunhai Fan, Shiping Song
Uniform silver-containing metal nanostructures with strong and stable surface-enhanced Raman scattering (SERS) signals hold great promise for developing ultrasensitive probes for biodetection. Nevertheless, the direct synthesis of such ready-to-use nanoprobes remains extremely challenging. Herein we report a DNA-mediated gold-silver nanomushroom with interior nanogaps directly synthesized and used for multiplex and simultaneous SERS detection of various DNA and RNA targets. The DNA involved in the nanostructures can act as not only gap DNA (mediated DNA) but also probe DNA (hybridized DNA), and DNA's involvement enables the nanostructures to have the inherent ability to recognize DNA and RNA targets...
February 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191696/a-new-approach-in-stem-cell-research-exosomes-their-mechanism-of-action-via-cellular-pathways
#7
REVIEW
Burak Derkus, Kaan C Emregul, Emel Emregul
Exosomes are nano-sized vesicles surrounded by a lipid membrane, which tend to be secreted towards extra-cellular environments. Despite being defined as vesicles involved in excretion of molecular wastes by Rose Johnstone in the 1970's, further studies revealed them to be effective in various biological processes such as cancer development, regulation of the immune system, intercellular communication, stem cell biology and tissue/organ regeneration. Although many studies dealing with the role of exosomes in stem cell differentiation and the use of exosomes isolated from stem cells, for treatment of several diseases have been published, the involved mechanisms remain largely unknown...
February 13, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28186207/complexity-of-the-ruminococcus-flavefaciens-fd-1-cellulosome-reflects-an-expansion-of-family-related-protein-protein-interactions
#8
Vered Israeli-Ruimy, Pedro Bule, Sadanari Jindou, Bareket Dassa, Sarah Moraïs, Ilya Borovok, Yoav Barak, Michal Slutzki, Yuval Hamberg, Vânia Cardoso, Victor D Alves, Shabir Najmudin, Bryan A White, Harry J Flint, Harry J Gilbert, Raphael Lamed, Carlos M G A Fontes, Edward A Bayer
Protein-protein interactions play a vital role in cellular processes as exemplified by assembly of the intricate multi-enzyme cellulosome complex. Cellulosomes are assembled by selective high-affinity binding of enzyme-borne dockerin modules to repeated cohesin modules of structural proteins termed scaffoldins. Recent sequencing of the fiber-degrading Ruminococcus flavefaciens FD-1 genome revealed a particularly elaborate cellulosome system. In total, 223 dockerin-bearing ORFs potentially involved in cellulosome assembly and a variety of multi-modular scaffoldins were identified, and the dockerins were classified into six major groups...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183677/hierarchical-micro-nano-structured-ti6al4v-surface-topography-via-two-step-etching-process-for-enhanced-hydrophilicity-and-osteoblastic-responses
#9
Byeong-Seok Moon, Sungwon Kim, Hyoun-Ee Kim, Tae-Sik Jang
Hierarchical micro-nano (HMN) surface structuring of dental implants is a fascinating strategy for achieving fast and mechanically stable fixation due to the synergetic effect of micro- and nano-scale surface roughness with surrounding tissues. However, the introduction of a well-defined nanostructure on a microstructure having complex surface geometry is still challenging. As a means of fabricating HMN surface on Ti6Al4V-ELI, target-ion induced plasma sputtering (TIPS) was used onto a sand-blasted, large-grit and acid-etched substrate...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183656/facile-synthesis-of-carbon-dot-and-residual-carbon-nanobeads-implications-for-ion-sensing-medicinal-and-biological-applications
#10
Rohit Ranganathan Gaddam, Sudip Mukherjee, Neelambaram Punugupati, D Vasudevan, Chitta Ranjan Patra, Ramanuj Narayan, Raju Vsn Kothapalli
Synthesis of carbon dots (Cdots) via chemical route involves disintegration of carbon materials into nano-domains, wherein, after extraction of Cdots, the remaining carbon material is discarded. The present work focuses on studying even the leftover carbon residue namely, carbon nanobeads (CNBs) as an equally important material for applications on par with that of carbon dot. It employs oxidative treatment of carbonised gum olibanum resin (GOR) to produce the carbons namely Cdots and CNBs (as the residue). The Cdots (~5-10nm) exhibit blue-green fluorescence with an optical absorption at ~300nm unlike the CNBs (40-50nm) which fail to exhibit fluorescence...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183594/a-novel-nano-hydroxyapatite-pmma-hybrid-scaffolds-adopted-by-conjugated-thermal-induced-phase-separation-tips-and-wet-chemical-approach-analysis-of-its-mechanical-and-biological-properties
#11
Radha G, Balakumar S, Balaji Venkatesan, Elangovan Vellaichamy
In this study, we report the preparation of nano-hydroxyapatite (nHAp) incorporated poly(methyl methacrylate) (PMMA) scaffolds by conjugated thermal induced phase separation (TIPS) and wet-chemical approach, which essentially facilitates the enhancement of both mechanical as well as biological properties of the scaffolds. The dissolution of PMMA was accomplished by acetone (Ace scaffold), ethanol-water (E-W scaffold) and isopropanol-water (I-W scaffold) mixtures as solvents. The existence of nHAp in PMMA matrix was investigated systematically...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28182433/vertical-substrate-mpcvd-epitaxial-nano-diamond-growth
#12
Yan-Kai Tzeng, Jingyuan Linda Zhang, Haiyu Lu, Hitoshi Ishiwata, Jeremy Dahl, Robert M K Carlson, Hao Yan, Peter R Schreiner, Jelena Vuckovic, Zhi-Xun Shen, Nicholas A Melosh, Steven Chu
Color center-containing nanodiamonds have many applications in quantum technologies and biology. Diamondoids, molecular-sized diamonds have been used as seeds in Chemical Vapor Deposition (CVD) growth. However, optimizing growth conditions to produce high crystal quality nanodiamonds with color centers requires varying growth conditions that often leads to ad-hoc and time-consuming, one-at-a-time testing of reaction conditions. In order to rapidly explore parameter space, we developed a microwave plasma CVD technique using a vertical, rather than horizontally oriented stage-substrate geometry...
February 9, 2017: Nano Letters
https://www.readbyqxmd.com/read/28168673/case-study-iii-the-construction-of-a-nanotoxicity-database-the-mod-enp-tox-experience
#13
Hanne Vriens, Dominik Mertens, Renaud Regret, Pinpin Lin, Jean-Pierre Locquet, Peter Hoet
The amount of experimental studies on the toxicity of nanomaterials is growing fast. Interpretation and comparison of these studies is a complex issue due to the high amount of variables possibly determining the toxicity of nanomaterials.Qualitative databases providing a structured combination, integration and quality evaluation of the existing data could reveal insights that cannot be seen from different studies alone. A few database initiatives are under development but in practice very little data is publicly available and collaboration between physicists, toxicologists, computer scientists and modellers is needed to further develop databases, standards and analysis tools...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28168672/compilation-of-data-and-modelling-of-nanoparticle-interactions-and-toxicity-in-the-nanopuzzles-project
#14
Andrea-Nicole Richarz, Aggelos Avramopoulos, Emilio Benfenati, Agnieszka Gajewicz, Nazanin Golbamaki Bakhtyari, Georgios Leonis, Richard L Marchese Robinson, Manthos G Papadopoulos, Mark Td Cronin, Tomasz Puzyn
The particular properties of nanomaterials have led to their rapidly increasing use in diverse fields of application. However, safety assessment is not keeping pace and there are still gaps in the understanding of their hazards. Computational models predicting nanotoxicity, such as (quantitative) structure-activity relationships ((Q)SARs), can contribute to safety evaluation, in line with general efforts to apply alternative methods in chemical risk assessment. Their development is highly dependent on the availability of reliable and high quality experimental data, both regarding the compounds' properties as well as the measured toxic effects...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28168670/biological-surface-adsorption-index-of-nanomaterials-modelling-surface-interactions-of-nanomaterials-with-biomolecules
#15
Ran Chen, Jim E Riviere
Quantitative analysis of the interactions between nanomaterials and their surrounding environment is crucial for safety evaluation in the application of nanotechnology as well as its development and standardization. In this chapter, we demonstrate the importance of the adsorption of surrounding molecules onto the surface of nanomaterials by forming biocorona and thus impact the bio-identity and fate of those materials. We illustrate the key factors including various physical forces in determining the interaction happening at bio-nano interfaces...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28163602/differential-pattern-of-deposition-of-nanoparticles-in-the-airways-of-exposed-workers
#16
Elizabeth Fireman, Rinat Edelheit, Moshe Stark, Amir Bar Shai
Ultrafine particles (UFP) have been postulated to significantly contribute to the adverse health effects associated with exposure to particulate matter (PM). Due to their extremely small size (aerodynamic diameter <100 nm), UFP are able to deposit deep within the lung after inhalation and evade many mechanisms responsible for the clearance of larger particles. There is a lack of biologically relevant personal exposure metrics for exposure to occupational- and environmental-related micro- and nano-sized PM...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28157204/multi-shell-nano-carboscavengers-for-petroleum-spill-remediation
#17
Enrique A Daza, Santosh K Misra, John Scott, Indu Tripathi, Christine Promisel, Brajendra K Sharma, Jacek Topczewski, Santanu Chaudhuri, Dipanjan Pan
Increasingly frequent petroleum contamination in water bodies continues to threaten our ecosystem, which lacks efficient and safe remediation tactics both on macro and nanoscales. Current nanomaterial and dispersant remediation methods neglect to investigate their adverse environmental and biological impact, which can lead to a synergistic chemical imbalance. In response to this rising threat, a highly efficient, environmentally friendly and biocompatible nano-dispersant has been developed comprising a multi-shelled nanoparticle termed 'Nano-CarboScavengers' (NCS) with native properties for facile recovery via booms and mesh tools...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28156099/shape-controllable-gold-nanoparticles-mos2-hybrids-prepared-by-tuning-edge-active-sites-and-surface-structures-of-mos2-via-temporally-shaped-femtosecond-pulses
#18
Pei Zuo, Lan Jiang, Xin Li, Bo Li, Yongda Xu, Xuesong Shi, Peng Ran, Tianbao Ma, Dawei Li, Liangti Qu, Yongfeng Lu, Costas P Grigoropoulos
Edge-active site control of MoS2 is crucial for applications such as chemical catalysis, synthesis of functional composites, and biochemical sensing. This work presents a novel nonthermal method to simultaneously tune surface chemical (edge-active sites) and physical (surface periodic micro/nano structures) properties of MoS2 using temporally shaped femtosecond pulses, through which shape-controlled gold nanoparticles are in situ and self-assembly grown on MoS2 surfaces to form Au-MoS2 hybrids. The edge-active sites with unbound sulfurs of laser-treated MoS2 drive the reduction of gold nanoparticles, while the surface periodic structures of laser-treated MoS2 assist the shape-controllable growth of gold nanoparticles...
February 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28152274/fe-3-seo42-dual-doped-nano-hydroxyapatite-a-novel-material-for-biomedical-applications
#19
Ammar Z Alshemary, Ahmet Engin Pazarceviren, Aysen Tezcaner, Zafer Evis
Dual ions substituted hydroxyapatite (HA) received attention from scientists and researchers in the biomedical field owing to their excellent biological properties. This paper presents a novel biomaterial, which holds potential for bone tissue applications. Herein, we have successfully incorporated ferric (Fe(3+) )/selenate (SeO42-) ions into the HA structure (Ca10-x-y Fey (PO4 )6-x (SeO4 )x (OH)2-x-y Oy ) (Fe-SeHA) through a microwave refluxing process. The Fe-SeHA materials were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and field emission scanning electron microscopy (FESEM)...
February 2, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28146361/nanomechanical-sensing-using-spins-in-diamond
#20
Michael S J Barson, Phani Kumar Peddibhotla, Preeti Ovartchaiyapong, Kumaravelu Ganesan, Richard L Taylor, Matthew Gebert, Zoe Mielens, Berndt Koslowski, David Allan Simpson, Liam P McGuinness, Jeffrey C McCallum, Steven Prawer, Shinobu Onoda, Takeshi Ohshima, Ania Claire Bleszynski Jayich, Fedor Jelezko, Neil B Manson, Marcus W Doherty
Nanomechanical sensors and quantum nanosensors are two rapidly developing technologies that have diverse interdisciplinary applications in biological and chemical analysis and microscopy. For example, nanomechanical sensors based upon nanoelectromechanical systems (NEMS) have demonstrated chip-scale mass spectrometry capable of detecting single macromolecules, such as proteins. Quantum nanosensors based upon electron spins of negatively-charged nitrogen-vacancy (NV) centers in diamond have demonstrated diverse modes of nanometrology, including single molecule magnetic resonance spectroscopy...
February 1, 2017: Nano Letters
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