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https://www.readbyqxmd.com/read/28715926/microencapsulation-of-anthocyanin-rich-black-soybean-coat-extract-by-spray-drying-using-maltodextrin-gum-arabic-and-skimmed-milk-powder
#1
Ana Kalušević, Steva Lević, Bojan Čalija, Milena Pantić, Miona Belović, Vladimir Pavlović, Branko Bugarski, Jela Milić, Slađana Žilić, Viktor Nedović
Black soybean coat is insufficiently valorised food production waste rich in anthocyanins. The goal of the study was to examine physicochemical properties of spray dried extract of black soybean coat in regard to carrier materials: maltodextrin, gum Arabic, and skimmed milk powder. Maltodextrin and gum Arabic-based microparticles were spherical and non-porous while skimmed milk powder-based were irregularly shaped. Low water activity of microparticles (0.31-033), good powders characteristics, high solubility (80...
July 18, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28654885/fabrication-of-pla-caco3-hybrid-micro-particles-as-carriers-for-water-soluble-bioactive-molecules
#2
Valeriya L Kudryavtseva, Li Zhao, Sergei I Tverdokhlebov, Gleb B Sukhorukov
We propose the use of polylactic acid/calcium carbonate (PLA/CaCO3) hybrid micro-particles for achieving improved encapsulation of water-soluble substances. Biodegradable porous CaCO3 microparticles can be loaded with wide range of bioactive substance. Thus, the formation of hydrophobic polymeric shell on surface of these loaded microparticles results on encapsulation and, hence, sealing internal cargo and preventing their release in aqueous media. In this study, to encapsulate proteins, we explore the solid-in-oil-in-water emulsion method for fabricating core/shell PLA/CaCO3 systems...
June 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28649247/an-antigen-presenting-and-apoptosis-inducing-polymer-microparticle-prolongs-alloskin-graft-survival-by-selectively-and-markedly-depleting-alloreactive-cd8-t-cells
#3
Wei Wang, Khawar Ali Shahzad, Miaochen Li, Aifeng Zhang, Lei Zhang, Tao Xu, Xin Wan, Chuanlai Shen
Selectively depleting the pathogenic T cells is a fundamental strategy for the treatment of allograft rejection and autoimmune disease since it retains the overall immune function of host. The concept of killer artificial antigen-presenting cells (KaAPCs) has been developed by co-coupling peptide-major histocompatibility complex (pMHC) multimer and anti-Fas monoclonal antibody (mAb) onto the polymeric microparticles (MPs) to induce the apoptosis of antigen-specific T cells. But little information is available about its in vivo therapeutic potential and mechanism...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28645629/production-and-characterization-of-aluminium-oxide-nanoshells-on-spray-dried-lactose
#4
Joel Hellrup, Mårten Rooth, Anders Johansson, Denny Mahlin
Atomic layer deposition (ALD) enables deposition of dense nanometer thick metal oxide nanoshells on powder particles with precise thickness control. This leads to products with low weight fraction coating, also when depositing on nano- or micron sized powder particles. This study aimed at investigating the aluminium oxide nanoshell thickness required to prevent moisture sorption. The nanoshells were produced with ALD on spray-dried lactose, which is amorphous and extremely hygroscopic. The particles were studied with dynamic vapor sorption between 0 and 50% RH, light scattering, scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, and polarized light microscopy...
June 20, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28642488/biomimetic-molecular-signaling-using-dna-walkers-on-microparticles
#5
Tulsi Ram Damase, Adam Spencer, Bamidele Samuel, Peter B Allen
We report the release of catalytic DNA walkers from hydrogel microparticles and the detection of those walkers by substrate-coated microparticles. This might be considered a synthetic biology analog of molecular signal release and reception. One type of particles was coated with components of a DNA one-step strand displacement (OSD) reaction to release the walker. A second type of particle was coated with substrate (or "track") for the molecular walker. We distinguish these particle types using fluorescence barcoding: we synthesized and distinguished multiple particle types with multicolor fluorescence microscopy and automated image analysis software...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619996/farnesoid-x-receptor-and-liver-x-receptor-ligands-initiate-formation-of-coated-platelets
#6
Amanda J Unsworth, Alexander P Bye, Dionne S Tannetta, Michael J R Desborough, Neline Kriek, Tanya Sage, Harriet E Allan, Marilena Crescente, Parveen Yaqoob, Timothy D Warner, Chris I Jones, Jonathan M Gibbins
OBJECTIVES: The liver X receptors (LXRs) and farnesoid X receptor (FXR) have been identified in human platelets. Ligands of these receptors have been shown to have nongenomic inhibitory effects on platelet activation by platelet agonists. This, however, seems contradictory with the platelet hyper-reactivity that is associated with several pathological conditions that are associated with increased circulating levels of molecules that are LXR and FXR ligands, such as hyperlipidemia, type 2 diabetes mellitus, and obesity...
June 15, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28605185/soft-matter-printed-circuit-board-with-uv-laser-micropatterning
#7
Tong Lu, Eric J Markvicka, Yichu Jin, Carmel Majidi
When encapsulated in elastomer, micropatterned traces of Ga-based liquid metal (LM) can function as elastically deformable circuit wiring that provides mechanically robust electrical connectivity between solid-state elements (e.g., transistors, processors, and sensor nodes). However, LM-microelectronics integration is currently limited by challenges in rapid fabrication of LM circuits and the creation of vias between circuit terminals and the I/O pins of packaged electronics. In this study, we address both with a unique layup for soft-matter electronics in which traces of liquid-phase Ga-In eutectic (EGaIn) are patterned with UV laser micromachining (UVLM)...
June 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28603970/microbots-decorated-with-silver-nanoparticles-kill-bacteria-in-aqueous-media
#8
Diana Vilela, Morgan M Stanton, Jemish Parmar, Samuel Sánchez
Water contamination is one of the most persistent problems of public health. Resistance of some pathogens to conventional disinfectants can require the combination of multiple disinfectants or increased disinfectant doses, which may produce harmful byproducts. Here, we describe an efficient method for disinfecting Escherichia coli and removing the bacteria from contaminated water using water self-propelled Janus microbots decorated with silver nanoparticles (AgNPs). The structure of a spherical Janus microbot consists of a magnesium (Mg) microparticle as a template that also functions as propulsion source by producing hydrogen bubbles when in contact with water, an inner iron (Fe) magnetic layer for their remote guidance and collection, and an outer AgNP-coated gold (Au) layer for bacterial adhesion and improving bactericidal properties...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28602504/polar-silica-based-stationary-phases-part-iii-neutral-silica-stationary-phase-with-surface-bound-maltose-for-affinity-chromatography-at-reduced-non-specific-interactions
#9
Renuka Rathnasekara, Ziad El Rassi
This research article reports the coating of large pore silica microparticles with a maltose layer to which bioaffinity ligands were attached via reductive amination reaction between the aldehyde activated maltose and the amino groups of the bioaffinity ligands. This was achieved first by the periodate oxidation of the maltose-silica (MALT-silica) yielding pairs of aldehyde groups at each monosaccharide ring. These di-aldehyde functionalities were then reacted with the primary amino groups of protein bio-affinity ligands and eventually formed Schiff bases (i...
June 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28521994/double-coated-enrofloxacin-microparticles-with-chitosan-and-alginate-preparation-characterization-and-taste-masking-effect-study
#10
Mengxi Liu, Daiping Yin, Hualin Fu, Fengying Deng, Guangneng Peng, Gang Shu, Zhixiang Yuan, Fei Shi, Juchun Lin, Ling Zhao, Lizi Yin, Guoqing Fan
Enrofloxacin (ENRO) is widely used as an antimicrobial drug for treatment of uncomplicated and complicated infections in veterinary medicine. Its bitter taste limits its clinical applications in veterinary. To mask the bitter taste of this drug, double-coated taste-masking microparticles of ENRO (DTME) were prepared through stearic acid solid dispersion and chitosan-alginate microparticle coating technologies. The taste-masking effect was evaluated by pig feeding experiment. Results showed that DTME exhibited a spherical-like shape (170490μm)...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28507706/ph-and-ligand-induced-release-of-loads-from-dna-acrylamide-hydrogel-microcapsules
#11
Wei-Ching Liao, Sivan Lilienthal, Jason S Kahn, Marianna Riutin, Yang Sung Sohn, Rachel Nechushtai, Itamar Willner
Herein, a method to construct stimuli-responsive DNA-acrylamide-based hydrogel microcapsules has been presented. This method involves the use of polyacrylamide chains modified with predesigned nucleic acid hairpin units and optionally single-strand tethers that provide the required hybridization and recognition functions to yield substrate-loaded stimuli-responsive hydrogel-based microcapsules. The synthesis of the microcapsules involves the loading of CaCO3 microparticles with the respective load substrates and the functionalization of the CaCO3 template particles with nucleic acid promoter units...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28499877/novel-superparamagnetic-microdevices-based-on-magnetized-plga-pla-microparticles-obtained-by-supercritical-fluid-emulsion-and-coating-by-carboxybetaine-functionalized-chitosan-allowing-the-tuneable-release-of-therapeutics
#12
Vincenzo Cricchio, Mark Best, Ernesto Reverchon, Nicola Maffulli, Gary Phillips, Matteo Santin, Giovanna Della Porta
When superparamagnetic nanoparticles (MAG) are loaded within microcarriers of thermosensitive and injectable biopolymers, "smart" microdevices are obtained: they respond to an external magnetic field through the release of any co-encapsulated molecules with a remote on-off control. Creating reliable and effective fabrication technologies for the production of these smart nano/microdevices remains a challenge. In this work, supercritical emulsion extraction technology is proposed for the fabrication of microcapsules with a core of poly-lactic-co-glycolic acid (PLGA) or polylactic acid (PLA) covered by carboxybetaine-functionalized chitosan (f-chi) and loaded with MAG (mean size of 6...
August 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28468950/er-stress-dependent-microparticles-derived-from-smooth-muscle-cells-promote-endothelial-dysfunction-during-thoracic-aortic-aneurysm-and-dissection
#13
Li-Xin Jia, Wen-Mei Zhang, Tao-Tao Li, Yan Liu, Chun-Mei Piao, You-Cai Ma, Yu Lu, Yuan Wang, Ting-Ting Liu, Yong-Fen Qi, Jie Du
The degeneration of vascular smooth muscle cell(s) (SMC) is one of the key features of thoracic aortic aneurysm and dissection (TAAD). We and others have shown that elevated endoplasmic reticulum (ER) stress causes SMC loss and TAAD formation, however, the mechanism of how SMC dysfunction contributes to intimal damage, leading to TAAD, remains to be explored. In the present study, in vitro assay demonstrated that elevated mechanical stretch (18% elongation, 3600 cycles/h) stimulated the ER stress response and microparticle(s) (MP) production from both SMC and endothelial cell(s) (EC) in a time-dependent manner...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28463363/from-natural-cotton-thread-to-sewable-energy-dense-supercapacitors
#14
Jian Zhi, Oliver Reiser, Youfu Wang, Aiguo Hu
Considering cost and flexibility, cotton thread is an ideal material for the fabrication of wearable and portable electronics. However, the capacitance of cotton thread based supercapacitors remains extremely low (below 50 mF cm(-2)) due to the insufficient capacitive utilization of active materials. In this work, ordered mesoporous carbon (OMC) membranes are rationally coupled with chemical vapour deposition derived graphene (CVD gr), to form a highly conductive carbon coating around cotton yarn. In this material design, OMC membranes act as hydrophilic nanoporous "ion reservoirs" to accumulate sufficient cations from a gel electrolyte, while CVD gr endows the composite thread low liner resistance (3...
May 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28457455/alginate-microparticles-as-oral-colon-drug-delivery-device-a-review
#15
REVIEW
Lissette Agüero, Dionisio Zaldivar-Silva, Luis Peña, Marcos L Dias
The increase in the research interest on alginate microparticles in pharmaceutical and biomedical areas confirms its potential use as an effective matrix for drug and cell delivery. Among the well known alginate properties, pH sensitivity remains as an attractive option for targeting of drug in the colon region. This essential aspect is advantageous to enhance therapeutic efficacy of treatment of inflammatory bowel diseases, which require multi-drug administration frequently in a long period. As consequence, severe side effect appears leading to discontinuation of therapy and affecting quality of patient life...
July 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28375309/engineering-polyshell-spherical-microcapsules-for-optimal-localized-light-absorption
#16
Yuri E Geints, Alexander A Zemlyanov, Ekaterina K Panina
Optical radiation absorption in a polylayer spherical microparticle simulating an inorganic/organic polyshell absorbing microcapsule is considered. With the aim of the finite-difference time-domain technique, the spatial distribution of the absorbed light power in microcapsules of various sizes and internal structure is numerically calculated. For the purpose of light absorption enhancement, we have engineered the optimal structure of a capsule consisting of a strong-refracting transparent outer coating and an absorbing layer which covers a liquid core...
March 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28373045/optimization-of-ziziphora-clinopodiodes-essential-oil-microencapsulation-by-whey-protein-isolate-and-pectin-a-comparative-study
#17
Mahmoud Hosseinnia, Mohammad Alizadeh Khaledabad, Hadi Almasi
The performance of whey protein isolate (WPI) and pectin as wall materials in encapsulation of Ziziphora clinopodiodes essential oil by ultrasonication method was compared. In this regard, using the response surface methodology, the influence of ultrasonication (US) power (50-150W) and core-coating ratio (10-100%) on the properties of microcapsules was evaluated. Increasing US power and core-coating ratio, caused to increase and decrease the particle size, respectively. The polydispersity index (PDI) of WPI coated microcapsules was increased by increasing of US power...
August 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28365287/properties-of-gelatin-based-films-incorporated-with-chitosan-coated-microparticles-charged-with-rutin
#18
Ilyes Dammak, Ana Mônica Quinta Barbosa Bittante, Rodrigo Vinicius Lourenço, Paulo José do Amaral Sobral
The aim of this study was development an active film based on gelatin incorporated with antioxidant, rutin carried into microparticles. The complexation between oppositely charged lecithin and chitosan was applied to prepare the chitosan-coated microparticles. The generated microparticles had an average size of 520±4nm and a span of 0.3 were formulated by a rotor-stator homogenize at the homogenization speed 10,000rpm. Composite films were prepared by incorporating chitosan-coated microparticles, at various concentrations (0...
August 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28356553/altering-the-coffee-ring-effect-by-adding-a-surfactant-like-viscous-polymer-solution
#19
Changdeok Seo, Daeho Jang, Jongjin Chae, Sehyun Shin
A uniform deposition of the suspended particles in an evaporating droplet is necessary in many research fields. Such deposition is difficult to achieve, because the coffee-ring effect dominates the internal flow in a droplet. The present study adopts a biocompatible, surfactant-like polymer (Polyethylene glycol, PEG) to break the coffee-ring effect and obtain a relatively uniform deposition of the microparticles with yielding multi-ring pattern over a droplet area. Movements of the suspended particles in evaporating droplets and deposition patterns of them on a glass substrate were analyzed with microscopic images and video files...
March 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298296/fabrication-of-synthetic-mesenchymal-stem-cells-for-the-treatment-of-acute-myocardial-infarction-in-mice
#20
Lan Luo, Junnan Tang, Kodai Nishi, Chen Yan, Phuong-Uyen Dinh, Jhon Cores, Takashi Kudo, Jinying Zhang, Tao-Sheng Li, Ke Cheng
RATIONALE: Stem cell therapy faces several challenges. It is difficult to grow, preserve, and transport stem cells before they are administered to the patient. Synthetic analogs for stem cells represent a new approach to overcome these hurdles and hold the potential to revolutionize regenerative medicine. OBJECTIVE: We aim to fabricate synthetic analogs of stem cells and test their therapeutic potential for treatment of acute myocardial infarction in mice. METHODS AND RESULTS: We packaged secreted factors from human bone marrow-derived mesenchymal stem cells (MSC) into poly(lactic-co-glycolic acid) microparticles and then coated them with MSC membranes...
May 26, 2017: Circulation Research
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