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https://www.readbyqxmd.com/read/29773365/a-synbiotic-multiparticulate-microcapsule-for-enhancing-inulin-intestinal-release-and-bifidobacterium-gastro-intestinal-survivability
#1
Bahgat Fayed, Amira Abood, Hoda S El-Sayed, Amal M Hashem, Nayra S H Mehanna
A novel synbiotic multiparticulate microparticle was produced in the current study to expand the synbiotic industrial applications. Initially, the inulin was fabricated into PLGA nanoparticles. After the inulin entrapment efficiency was boosted to reach 92.9 ± 8.4% by adjusting the formulation parameters, the developed particles were characterized by different techniques such as particle size analyzer, TEM, and TLC. The obtained data showed that the particle size was 115.8 ± 82.7 nm, the particles had smooth surface and round shape, and the fabrication procedure did not affect the integrity of the inulin...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29761787/osteoinducing-scaffolds-with-multi-layered-biointerface
#2
Ekaterina A Grebenik, Varvara Grinchenko, Semyon Nikolaevich Churbanov, Nikita Minaev, Boris Shavkuta, Pavel Alexandrovich Melnikov, Denis Butnaru, Yury Rochev, Victor Nikolayevich Bagratashvili, Peter S Timashev
This study was aimed to design and characterize hybrid tissue-engineered constructs composed of osteoinducing polylactide-based scaffolds with multi-layered cellular biointerface for bone tissue reconstruction. Three-dimensional scaffolds with improved hydrophilic and osteoinducing properties were produced using the surface-selective laser sintering (SSLS) method. The designed scaffold pattern had dimensions of 8×8×2.5 mm and ladder-like pores (~ 700 μm in width). Hyaluronic acid-coated polylactide microparticles (~ 100 μm in diameter) were used as building blocks and water was used as the photosensitizer for SSLS followed by photocross-linking with Irgacure 2959 photoinitiator...
May 15, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29748879/poly-l-ornithine-fucoidan-coated-calcium-carbonate-microparticles-by-layer-by-layer-self-assembly-technique-for-cancer-theranostics
#3
Pei Wang, Ranjith Kumar Kankala, Jingqian Fan, Ruimin Long, Yuangang Liu, Shibin Wang
Recently, the layer-by-layer (LbL) self-assembly technology has attracted the enormous interest of researchers in synthesizing various pharmaceutical dosage forms. Herewith, we designed a biocompatible drug delivery system containing the calcium carbonate microparticles (CaCO3 MPs) that coated with the alternatively charged polyelectrolytes, i.e., poly-L-ornithine (PLO)/fucoidan by LbL self-assembly process (LbL MPs). Upon coating with the polyelectrolytes, the mean particle size of MPs obtained from SEM observations increased from 1...
May 10, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29729337/electrospray-assisted-encapsulation-of-caffeine-in-alginate-microhydrogels
#4
Alireza Mehregan Nikoo, Rassoul Kadkhodaee, Behrouz Ghorani, Hussam Razzaq, Nick Tucker
One of the major challenges with microencapsulation and delivery of low molecular weight bioactive compounds is their diffusional loss during storage and process conditions as well as under gastric conditions. In an attempt to slow down the release rate of core material, electrospray fabricated calcium alginate microhydrogels were coated with low molecular weight and high molecular weight chitosans. Caffeine as a hydrophilic model compound was used due to its several advantages on human behavior especially increasing consciousness...
May 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29726524/extending-axial-focus-of-optical-coherence-tomography-using-parallel-multiple-aperture-synthesis
#5
En Bo, Xin Ge, Xiaojun Yu, Jianhua Mo, Linbo Liu
Compromising the inherent trade-off between transverse resolution and depth of focus (DOF) remains a long-standing issue in optical coherence tomography (OCT). In this work, we report a novel technique-parallel multiple aperture synthesis (pMAS) to simultaneously generate multiple optical apertures in an OCT sample arm by employing a two-surface coated mirror. In the proposed pMAS, the DOF is extended by a factor of 16.49 without sacrificing the transverse resolution for proof-of-concept experiments when multiple distinctive apertures are digitally synthesized...
May 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29725005/reconfigurable-engineered-motile-semiconductor-microparticles
#6
Ugonna Ohiri, C Wyatt Shields, Koohee Han, Talmage Tyler, Orlin D Velev, Nan Jokerst
Locally energized particles form the basis for emerging classes of active matter. The design of active particles has led to their controlled locomotion and assembly. The next generation of particles should demonstrate robust control over their active assembly, disassembly, and reconfiguration. Here we introduce a class of semiconductor microparticles that can be comprehensively designed (in size, shape, electric polarizability, and patterned coatings) using standard microfabrication tools. These custom silicon particles draw energy from external electric fields to actively propel, while interacting hydrodynamically, and sequentially assemble and disassemble on demand...
May 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29723705/nanoparticle-in-microparticle-oral-drug-delivery-system-of-a-clinically-relevant-darunavir-ritonavir-antiretroviral-combination
#7
Robin Augustine, Dana Levin Ashkenazi, Roni Sverdlov Arzi, Vita Zlobin, Rona Shofti, Alejandro Sosnik
Nanonizationhas been extensively investigated to increase theoral bioavailability of hydrophobicdrugsin general andantiretrovirals(ARVs)used inthe therapy of the human immunodeficiency virus (HIV) infection in particular. Weanticipatedthatin the caseofprotease inhibitors, a family of pH-dependent ARVsthatdisplay high aqueous solubility undertheacidconditionsof thestomach andextremely low solubilityunder the neutral ones ofthe small intestine, this strategy will failowing to an uncontrolled dissolution-re-precipitation process that will take place along the gastrointestinal tract...
April 30, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29718673/particulate-coatings-via-evaporation-induced-self-assembly-of-polydisperse-colloidal-lignin-on-solid-interfaces
#8
Oriol Cusola, Samu Kivistö, Sampsa Vierros, Piotr Batys, Mariko Ago, Blaise L Tardy, Luiz G Greca, M Blanca Roncero, Maria Sammalkorpi, Orlando J Rojas
Polydisperse smooth and spherical biocolloidal particles were suspended in aqueous media and allowed to consolidate via evaporation-induced self-assembly (EISA). The stratification of the particles at the solid-air interface was markedly influenced but not monotonically, by the drying rate. Cross section imaging via electron microscopy indicated a structured coating morphology that was distinctive from that obtained by using mineral particles with mono- or bimodal distribution. Segregation patterns were found to derive from the interplay of particle diffusion, inter-particle forces and settling dynamics...
May 2, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29684688/layer-by-layer-hollow-photosensitizer-microcapsule-design-via-a-manganese-carbonate-hard-template-for-photodynamic-therapy-in-cells
#9
Andreza Ribeiro Simioni, Priscila Costa Carvalho de Jesus, Antonio Claudio Tedesco
BACKGROUND: Microcapsules fabricated using layer-by-layer self-assembly have unique properties, making them attractive for drug delivery applications. The technique has been improved, allowing the deposition of multiple layers of oppositely charged polyelectrolytes on spherical, colloidal templates. These templates can be decomposed by coating multiple layers, resulting in hollow shells. In this paper, we describe a novel drug delivery system for loading photosensitizer drugs into hollow multilayered microcapsules for photoprocess applications...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29684533/lipid-coated-mannitol-core-microparticles-for-sustained-release-of-protein
#10
Bifeng Wang, Wolfgang Friess
Parenteral sustained release systems for proteins which provide therapeutic levels over a longer period avoiding frequent administration, which preserve protein stability during manufacturing, storage and application and which are biodegradable and highly biocompatible in the body are intensively sought after. The aim of this study was to generate and study mannitol core microparticles loaded with a monoclonal antibody IgG1 and coated with lipid either hard fat or glyceryl stearate at different coating levels...
April 20, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29682803/mechanobiological-mimicry-of-helper-t-lymphocytes-to-evaluate-cell-biomaterials-crosstalk
#11
Mohammad Mahdi Hasani-Sadrabadi, Fatemeh S Majedi, Steven J Bensinger, Benjamin M Wu, Louis-S Bouchard, Paul S Weiss, Alireza Moshaverinia
The unique properties of immune cells have inspired many efforts in engineering advanced biomaterials capable of mimicking their behaviors. However, an inclusive model capable of mimicking immune cells in different situations remains lacking. Such models can provide invaluable data for understanding immune-biomaterial crosstalk. Inspired by CD4+ T cells, polymeric microparticles with physicochemical properties similar to naïve and active T cells are engineered. A lipid coating is applied to enhance their resemblance and provide a platform for conjugation of desired antibodies...
April 23, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29661315/starch-film-coated-microparticles-for-oral-colon-specific-drug-delivery
#12
Jin Chen, Xiaoxi Li, Ling Chen, Fengwei Xie
The aim of this study was to prepare and characterize a novel type of starch-coated microparticles (MPs) allowing site-specific delivery of bioactives to the colon. An oral colon-specific controlled-release system was developed in the form of MPs coated with a resistant starch (RS2/RS3) film (RS@MPs) through an aqueous suspension coating process. The RS2 was chosen from a high-amylose cornstarch with 88.5% digestion resistibility. The RS3 was prepared by a high-temperature/pressure (HTP) treatment, with the following of enzymatic debranching, and retrogradation, resulting in a dramatic increase in enzymatic resistance (RS3 content: 76...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29556569/preparation-of-iron-oxide-silica-particles-for-zika-viral-rna-extraction
#13
Alex H F Lee, Steven F Gessert, Yutao Chen, Nikolay V Sergeev, Babak Haghiri
In this work, a robust synthetic pathway for magnetic core preparation and silica surface coating of magnetic microparticles is presented. Silica-coated magnetic particles are widely used to extract DNA and RNA from various biological samples. We present a novel route for the synthesis of iron oxide silica particles (Fe3 O4 @Silica) and demonstrate their performance for extracting ZIKA viral RNA from serum. The iron (II, III) oxide (Fe3 O4 ), magnetite core is first prepared by ammonia neutralization of ferrous and ferric chloride aqueous solution under argon, followed by the addition of citrate salt to stabilize the surface of the resultant magnetic nanospheres...
March 2018: Heliyon
https://www.readbyqxmd.com/read/29525682/s-allylmercaptocysteine-attenuates-posaconazole-induced-adverse-effects-in-mice-through-antioxidation-and-anti-inflammation
#14
Lijun Yang, Min Yang, Siying Li, Zhongxi Zhao
Posaconazole is a broad-spectrum antibacterial drug for the treatment of invasive fungal infections. However, its clinical usage is limited by a lot of adverse reactions such as diarrhea. S-allylmercaptocysteine (SAMC), a garlic organosulfur compound, has a strong antioxidative and anti-inflammatory activity. This study aimed to examine the protective effects of SAMC on posaconazole-induced adverse effects. Mice were treated with the blank control, enteric coated posaconazole microparticles (POS group) and its combination with SAMC (Combination group)...
May 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29517977/nanospikes-functionalization-as-a-universal-strategy-to-disperse-hydrophilic-particles-in-non-polar-media
#15
Tian Hang, Hui-Jiuan Chen, Ji Wang, Di-An Lin, Jiangming Wu, Di Liu, Yuhong Cao, Chengduan Yang, Chenglin Liu, Shuai Xiao, Meilin Gu, Shuolin Pan, Mei X Wu, Xi Xie
Dispersion of hydrophilic particles in non-polar media has many important applications yet remains difficult. Surfactant or amphiphilic functionalization was conventionally applied to disperse particles but is highly dependent on the particle/solvent system and may induce unfavorable effects and impact particle hydrophilic nature. Recently 2 μm size polystyrene microbeads coated with ZnO nanospikes have been reported to display anomalous dispersity in phobic media without using surfactant or amphiphilic functionalization...
May 4, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29486302/brain-targeting-of-resveratrol-by-nasal-administration-of-chitosan-coated-lipid-microparticles
#16
Valentina Trotta, Barbara Pavan, Luca Ferraro, Sarah Beggiato, Daniela Traini, Larissa Gomes Des Reis, Santo Scalia, Alessandro Dalpiaz
Lipid microparticles (LMs) uncoated or coated with chitosan and containing the neuroprotective polyphenol resveratrol were developed for its targeting to the brain via nasal administration. The lipid microparticles loaded with resveratrol (LMs-Res) were produced by melt emulsification, using stearic acid as lipid material and phosphatidylcholine as the surfactant. The chitosan coated particles LMs-Res-Ch (1.75% w/v chitosan solution) and LMs-Res-Ch-plus (8.75% w/v chitosan solution) were prepared by adding a chitosan solution to the formed particles...
June 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29468814/effects-of-substrate-stiffness-on-dental-pulp-stromal-cells-in-culture
#17
Laura Datko Williams, Amanda Farley, Matthew Cupelli, Satish Alapati, Marian S Kennedy, Delphine Dean
Dental pulp stromal cells (DPSCs) can be differentiated down lineages known to either express bone or dentin specific protein markers. Since the differentiation of cells can be heavily influenced by their environment, it may be possible to influence the osteogenic/odontogenic potential of DPSCs by modulating the mechanical properties of substrate on which they are grown. In this study, human DPSCs were grown with and without hydroxyapatite (HA) microparticles on a range of substrates including fibronectin-coated hydrogels and glass substrates, which represented an elastic moduli range of approximately 3 kPa-50 GPa, over a 21-day period...
February 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29455987/design-and-biological-response-of-doxycycline-loaded-chitosan-microparticles-for-periodontal-disease-treatment
#18
Silvana Gjoseva, Nikola Geskovski, Simona Dimchevska Sazdovska, Riste Popeski-Dimovski, Gjorgji Petruševski, Kristina Mladenovska, Katerina Goracinova
The aim of this study was to develop chitosan (CS) microparticulated mucoadhesive drug delivery system (DDS) with improved therapeutic performance and biological responce. Ionotropic gelation/spray drying process was used for preparation of doxycycline hyclate (DOXY) loaded low and medium molecular weight (LMw and MMw) CS/sodium tripolyphosphate microparticles (CS/TPP MPs), further coated with ethyl cellulose (EC) using coacervation/solvent displacement technique. The relevant physico-chemical and biopharmaceutical properties were optimized using experimental design approach...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29448484/rolling-and-aging-in-temperature-ramp-soft-adhesion
#19
Giuseppe Boniello, Christophe Tribet, Emmanuelle Marie, Vincent Croquette, Dražen Zanchi
Immediately before adsorption to a horizontal substrate, sinking polymer-coated colloids can undergo a complex sequence of landing, jumping, crawling, and rolling events. Using video tracking, we studied the soft adhesion to a horizontal flat plate of micron-size colloids coated by a controlled molar fraction f of the poly(lysine)-grafted-poly(N-isopropylacrylamide) (PLL-g-PNIPAM) which is a temperature-sensitive polymer. We ramp the temperature from below to above T_{c}=32±1^{∘}C, at which the PNIPAM polymer undergoes a transition, triggering attractive interaction between microparticles and surface...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29421560/dual-non-viral-gene-delivery-from-microparticles-within-3d-high-density-stem-cell-constructs-for-enhanced-bone-tissue-engineering
#20
Alexandra McMillan, Minh Khanh Nguyen, Tomas Gonzalez-Fernandez, Peilin Ge, Xiaohua Yu, William L Murphy, Daniel J Kelly, Eben Alsberg
High-density mesenchymal stem cell (MSC) aggregates can be guided to form bone-like tissue via endochondral ossification in vitro when culture media is supplemented with proteins, such as growth factors (GFs), to first guide the formation of a cartilage template, followed by culture with hypertrophic factors. Recent reports have recapitulated these results through the controlled spatiotemporal delivery of chondrogenic transforming growth factor-β1 (TGF-β1) and chondrogenic and osteogenic bone morphogenetic protein-2 (BMP-2) from microparticles embedded within human MSC aggregates to avoid diffusion limitations and the lengthy, costly in vitro culture necessary with repeat exogenous supplementation...
April 2018: Biomaterials
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