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microparticle coating

Alex H F Lee, Steven F Gessert, Yutao Chen, Nikolay V Sergeev, Babak Haghiri
In this work, a robust synthetic pathway for magnetic core preparation and silica surface coating of magnetic microparticles is presented. Silica-coated magnetic particles are widely used to extract DNA and RNA from various biological samples. We present a novel route for the synthesis of iron oxide silica particles (Fe3 O4 @Silica) and demonstrate their performance for extracting ZIKA viral RNA from serum. The iron (II, III) oxide (Fe3 O4 ), magnetite core is first prepared by ammonia neutralization of ferrous and ferric chloride aqueous solution under argon, followed by the addition of citrate salt to stabilize the surface of the resultant magnetic nanospheres...
March 2018: Heliyon
Lijun Yang, Min Yang, Siying Li, Zhongxi Zhao
Posaconazole is a broad-spectrum antibacterial drug for the treatment of invasive fungal infections. However, its clinical usage is limited by a lot of adverse reactions such as diarrhea. S-allylmercaptocysteine (SAMC), a garlic organosulfur compound, has a strong antioxidative and anti-inflammatory activity. This study aimed to examine the protective effects of SAMC on posaconazole-induced adverse effects. Mice were treated with the blank control, enteric coated posaconazole microparticles (POS group) and its combination with SAMC (Combination group)...
March 8, 2018: International Immunopharmacology
Tian Hang, Hui-Jiuan Chen, Ji Wang, Di-An Lin, Jiangming Wu, Di Liu, Yuhong Cao, Chengduan Yang, Chenglin Liu, Shuai Xiao, Meilin Gu, Shuolin Pan, Mei X Wu, Xi Xie
Dispersion of hydrophilic particles in non-polar media has many important applications yet remains difficult. Surfactant or amphiphilic functionalization was conventionally applied to disperse particles but is highly dependent on the particle/solvent system and may induce unfavorable effects and impact particle hydrophilic nature. Recently 2 μm size polystyrene microbeads coated with ZnO nanospikes have been reported to display anomalous dispersity in phobic media without using surfactant or amphiphilic functionalization...
March 8, 2018: Nanotechnology
Valentina Trotta, Barbara Pavan, Luca Ferraro, Sarah Beggiato, Daniela Traini, Larissa Gomes Des Reis, Santo Scalia, Alessandro Dalpiaz
Lipid microparticles (LMs) uncoated or coated with chitosan and containing the neuroprotective polyphenol, resveratrol were developed for its targeting to the brain via nasal administration. The lipid microparticles loaded with resveratrol (LMs-Res) were produced by melt emulsification, using stearic acid as lipid material and phosphatidylcholine as the surfactant. The chitosan coated particles LMs-Res-Ch (1.75% w/v chitosan solution) and LMs-Res-Ch-plus (8.75 % w/v chitosan solution) were prepared by adding a chitosan solution to the formed particles...
February 24, 2018: European Journal of Pharmaceutics and Biopharmaceutics
L Datko Williams, A Farley, M Cupelli, S Alapati, M S Kennedy, D Dean
Dental pulp stromal cells (DPSCs) can be differentiated down lineages known to either express bone or dentin specific protein markers. . Since the differentiation of cells can be heavily influenced by their environment, it may be possible to influence the osteogenic/odontogenic potential of DPSCs by modulating the mechanical properties of substrate on which they are grown. In this study, human DPSCs were grown with and without hydroxyapatite (HA) microparticles on a range of substrates including fibronectin-coated hydrogels and glass substrates, which represented an elastic moduli range of ∼ 3 kPa - 50 GPa, over a 21 day period...
February 22, 2018: Journal of Biomedical Materials Research. Part A
Silvana Gjoseva, Nikola Geskovski, Simona Dimchevska Sazdovska, Riste Popeski-Dimovski, Gjorgji Petruševski, Kristina Mladenovska, Katerina Goracinova
The aim of this study was to develop chitosan (CS) microparticulated mucoadhesive drug delivery system (DDS) with improved therapeutic performance and biological responce. Ionotropic gelation/spray drying process was used for preparation of doxycycline hyclate (DOXY) loaded low and medium molecular weight (LMw and MMw) CS/sodium tripolyphosphate microparticles (CS/TPP MPs), further coated with ethyl cellulose (EC) using coacervation/solvent displacement technique. The relevant physico-chemical and biopharmaceutical properties were optimized using experimental design approach...
April 15, 2018: Carbohydrate Polymers
Giuseppe Boniello, Christophe Tribet, Emmanuelle Marie, Vincent Croquette, Dražen Zanchi
Immediately before adsorption to a horizontal substrate, sinking polymer-coated colloids can undergo a complex sequence of landing, jumping, crawling, and rolling events. Using video tracking, we studied the soft adhesion to a horizontal flat plate of micron-size colloids coated by a controlled molar fraction f of the poly(lysine)-grafted-poly(N-isopropylacrylamide) (PLL-g-PNIPAM) which is a temperature-sensitive polymer. We ramp the temperature from below to above T_{c}=32±1^{∘}C, at which the PNIPAM polymer undergoes a transition, triggering attractive interaction between microparticles and surface...
January 2018: Physical Review. E
Alexandra McMillan, Minh Khanh Nguyen, Tomas Gonzalez-Fernandez, Peilin Ge, Xiaohua Yu, William L Murphy, Daniel J Kelly, Eben Alsberg
High-density mesenchymal stem cell (MSC) aggregates can be guided to form bone-like tissue via endochondral ossification in vitro when culture media is supplemented with proteins, such as growth factors (GFs), to first guide the formation of a cartilage template, followed by culture with hypertrophic factors. Recent reports have recapitulated these results through the controlled spatiotemporal delivery of chondrogenic transforming growth factor-β1 (TGF-β1) and chondrogenic and osteogenic bone morphogenetic protein-2 (BMP-2) from microparticles embedded within human MSC aggregates to avoid diffusion limitations and the lengthy, costly in vitro culture necessary with repeat exogenous supplementation...
January 3, 2018: Biomaterials
Elena K Volkova, Irina Yu Yanina, Elina A Genina, Alexey N Bashkatov, Julia G Konyukhova, Alexey P Popov, Elena S Speranskaya, Alla B Bucharskaya, Nikita A Navolokin, Irina Yu Goryacheva, Vyacheslav I Kochubey, Gleb B Sukhorukov, Igor V Meglinski, Valery V Tuchin
Delivery and spatial localization of upconversion luminescent microparticles [Y2O3:Yb, Er] (mean size ∼1.6  μm) and quantum dots (QDs) (CuInS2/ZnS nanoparticles coated with polyethylene glycol-based amphiphilic polymer, mean size ∼20  nm) inside rat skin was studied in vivo using a multimodal optical imaging approach. The particles were embedded into the skin dermis to the depth from 300 to 500  μm through microchannels performed by fractional laser microablation. Low-frequency ultrasound was applied to enhance penetration of the particles into the skin...
February 2018: Journal of Biomedical Optics
Weibing Chen, Wenjin Qi, Wei Lu, Nikhil Roy Chaudhury, Jiangtan Yuan, Lidong Qin, Jun Lou
The low toxicity of molybdenum disulfide (MoS2 ) atomically thin film and microparticles is confirmed via cytotoxicity and patch testing in this report. The toxicity of MoS2 thin film and microparticles is extensively studied but is still inconclusive due to potential organic contamination in the preparations of samples. Such contamination is avoided here through preparing MoS2 atomically thin film via direct sulfurization of molybdenum thin film on quartz plate, which permits a direct assessment of its toxicity without any contamination...
January 22, 2018: Small
Caspar Schreuer, Stijn Vandewiele, Filip Strubbe, Kristiaan Neyts, Filip Beunis
HYPOTHESIS: Colloidal particles in a pure nonpolar solvent are expected to be in a state of dynamic equilibrium where a particle's charge fluctuates around a stable mean value. However, we find that PHSA-coated PMMA microparticles in dodecane gain positive charge over time. We hypothesize that this phenomenon is prompted by the high electric field (∼1 V/µm) that is applied in these measurements. Hence, we expect the reaction rate at which charge builds up on the particle to change when modifying the measurement parameters...
January 11, 2018: Journal of Colloid and Interface Science
Lacey Johnson, Shereen Tan, Emily Jenkins, Ben Wood, Denese C Marks
BACKGROUND: Alternatives to room temperature storage of platelets (PLTs) are of interest to support blood banking logistics. The aim of this study was to compare the presence of biologic response modifiers (BRMs) in PLT concentrates stored under conventional room temperature conditions with refrigerated or cryopreserved PLTs. STUDY DESIGN AND METHODS: A three-arm pool-and-split study was carried out using buffy coat-derived PLTs stored in 30% plasma/70% SSP+. The three matched treatment arms were as follows: room temperature (20-24°C), cold (2-6°C), and cryopreserved (-80°C with DMSO)...
January 12, 2018: Transfusion
Zeinab Heidariyan, Mohammad Hossein Ghanian, Mohsen Ashjari, Zahra Farzaneh, Mostafa Najarasl, Mehran Rezaei Larijani, Abbas Piryaei, Massoud Vosough, Hossein Baharvand
Biomedical application of human pluripotent stem cell-derived hepatocyte-like cells (hPSC-HLCs) relies on efficient large-scale differentiation, which is commonly performed by a suspension culture of three-dimensional (3D) multicellular spheroids in bioreactors. However, this approach requires large amounts of growth factors (GFs) and the need to overcome limited diffusional transport posed by the inherent 3D structure of hPSC spheroids. Here, we have hypothesized that localized delivery of GFs by incorporation of GF-laden degradable polymeric microparticles (MPs) within the hPSC spheroids would circumvent such limitations...
January 2, 2018: Biomaterials
Rachael M Kenney, Matthew W Boyce, Nathan Whitman, Brenden P Kromhout, Matthew R Lockett
Paper-based cultures are an emerging platform for preparing 3D tissue-like structures. Chemical gradients can be imposed upon these cultures, generating microenvironments similar to those found in poorly vascularized tumors. There is increasing evidence that the tumor microenvironment is responsible for promoting drug resistance and increased invasiveness. Acidosis, or the acidification of the extracellular space, is particularly important in promoting these aggressive cancer phenotypes. To better understand how cells respond to acidosis there is a need for 3D culture platforms that not only model relevant disease states, but also contain sensors capable of quantifying the extracellular environment...
January 11, 2018: Analytical Chemistry
Hui-Jiuan Chen, Tian Hang, Chengduan Yang, Guishi Liu, Di-An Lin, Jiangming Wu, Shuolin Pan, Bo-Ru Yang, Jun Tao, Xi Xie
In situ effective separation of oil pollutants including oil spills and oil emulsions from water is an emerging technology yet remains challenging. Hydrophobic micro- or nano-materials with ferromagnetism have been explored for oil removal, yet the separation efficiency of an oil emulsion was compromised due to the limited dispersion of hydrophobic materials in water. A surfactant coating on microparticles prevented particle aggregation, but reduced oil absorption and emulsion cleaning ability. Recently, polystyrene microbeads covered with nanospikes have been reported to display anomalous dispersion in phobic media without surfactants...
January 10, 2018: Nanoscale
Dana Westmeier, Gernot Posselt, Angelina Hahlbrock, Sina Bartfeld, Cecilia Vallet, Carmen Abfalter, Dominic Docter, Shirley K Knauer, Silja Wessler, Roland H Stauber
Enteric bacteria may cause severe diseases, including gastric cancer-associated Helicobacter pylori. Their infection paths overlap with the oro-gastrointestinal uptake route for nanoparticles, increasingly occurring during environmental or consumer/medical exposure. By comprehensive independent analytical methods, such as live cell fluorescence, electron as well as atomic force microscopy and elemental analysis, we show that a wide array of nanoparticles (NPs) but not microparticles form complexes with H. pylori and enteric pathogens without the need for specific functionalization...
January 5, 2018: Nanoscale
Chun Y Wong, Hani Al-Salami, Crispin R Dass
Diabetes mellitus is a chronic metabolic health disease affecting the homeostasis of blood sugar levels. However, subcutaneous injection of insulin can lead to patient non-compliance, discomfort, pain and local infection. Sub-micron sized drug delivery systems have gained attention in oral delivery of insulin for diabetes treatment. In most of the recent literature, the terms "microparticles" and "nanoparticle" refer to particles where the dimensions of the particle are measured in micrometers and nanometers respectively...
February 15, 2018: International Journal of Pharmaceutics
Hyeri Kim, Jangwoo Cho, Jaehong Cho, Bum Jun Park, Jin Woong Kim
We present a straightforward and robust method for the synthesis of Janus colloid surfactants with distinct amphiphilicity and magnetic responsiveness. To this end, hydroxyl-functionalized amphiphilic Janus microparticles are synthesized by seeded monomer swelling and subsequent photo-polymerization. By incorporating controlled amounts of hydroxyl groups on poly (styrene-co-vinyl alcohol) seed particles, we adjust the interfacial tension between the seed polymer and the poly (tetradecyl acrylate) secondary polymer (γ13)...
December 15, 2017: ACS Applied Materials & Interfaces
Xiaoying Xing, Xiuyun Zhao, Jia Ding, Dongming Liu, Gaofu Qi
Surfactin, a lipopeptide produced by Bacillus species, has been used for the oral delivery of insulin. In this study, another lipopeptide of iturin was tested for its ability to orally delivery insulin alone or plus surfactin. Iturin could form co-precipitate with insulin at acidic pH values. After treatment by ultrasonification, the structure of coprecipitate was destroyed that led to a significant decrease in hypoglycemic effect after oral administration. Iturin weakly binds to (Kd = 257 μM) and induce insulin structure more compact that is favorable for insulin uptake by the intestine...
November 2018: Drug Delivery
Alexander Heiss, Birger Freisinger, Evi Held-Föhn
The oxidation based antimicrobial activity of silver is long known. Microparticles with a particular silver-ruthenium coating and specific physical properties were developed. The coating showed a considerably increased silver ion release rate in comparison to a plain silver coating. Accordingly, an exposure of Escherichia coli and Staphylococcus aureus to these silver-ruthenium coated microparticles resulted in a time and concentration dependent cell killing. Even though contact killing may contribute to this efficacy, rather a release associated diffusion gradient dependent killing was observed...
December 5, 2017: Biointerphases
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