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https://www.readbyqxmd.com/read/29146990/how-gluttonous-cell-aggregates-clear-substrates-coated-with-microparticles
#1
Grégory Beaune, Andy Y W Lam, Sylvie Dufour, Françoise M Winnik, Françoise Brochard-Wyart
We study the spreading of cell aggregates deposited on adhesive substrates decorated with microparticles (MPs). A cell monolayer expands around the aggregate. The cells on the periphery of the monolayer take up the MPs, clearing the substrate as they progress and forming an aureole of cells filled with MPs. We study the dynamics of spreading and determine the width of the aureole and the level of MP internalization in cells as a function of MP size, composition, and density. From the radius and width of the aureole, we quantify the volume fraction of MPs within the cell, which leads to an easy, fast, and inexpensive measurement of the cell - particle internalization...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29145085/analysis-of-microplastics-in-water-by-micro-raman-spectroscopy-release-of-plastic-particles-from-different-packaging-into-mineral-water
#2
Darena Schymanski, Christophe Goldbeck, Hans-Ulrich Humpf, Peter Fürst
Microplastics are anthropogenic contaminants which have been found in oceans, lakes and rivers. Investigations focusing on drinking water are rare and studies have mainly been using micro-Fourier Transform Infrared Spectroscopy (μ-FT-IR). A major limitation of this technique is its inability to detect particles smaller than 20 μm. However, micro-Raman spectroscopy is capable of detecting even smaller particle sizes. Therefore, we show that this technique, which was used in this study, is particularly useful in detecting microplastics in drinking water where particle sizes are in the low micrometer range...
November 6, 2017: Water Research
https://www.readbyqxmd.com/read/29132177/an-insight-on-silk-protein-sericin-from-processing-to-biomedical-application
#3
Farogh Ahsan, Tarique Mahmood Ansari, Shazia Usmani, Paramdeep Bagga
Silks are naturally occurring polymers that have been used clinically as sutures for hundreds of years. It's so for obtained from insects or worms, silk consists of a filament core protein, termed fibroin, and a glue-like coating made up of sericin proteins. An important component of silk has an extended history of being discarded as a waste in the course of silk processing. The cost of sericin for tissue engineering is underestimated and its capability in using as regenerative remedy has simply began to be explored...
November 13, 2017: Drug Research
https://www.readbyqxmd.com/read/29080504/isolation-of-breast-cancer-ctcs-with-multitargeted-buoyant-immunomicrobubbles
#4
Guankui Wang, Halli Benasutti, Jessica F Jones, Guixin Shi, Michael Benchimol, Sandeep Pingle, Santosh Kesari, Yasan Yeh, Li-En Hsieh, Yu-Tsueng Liu, Anthony Elias, Dmitri Simberg
Circulating tumor cells (CTCs) are extremely rare cells found in blood of metastatic cancer patients. There is a need for inexpensive technologies for fast enrichment of CTCs from large blood volumes. Previous data showed that antibody-conjugated lipid shell immuno-microbubbles (MBs) bind and isolate cells from biological fluids by flotation. Here, blood-stable MBs targeted to several surface markers for isolation of breast tumor cells were developed. MBs coated with anti-human EpCAM antibodies showed efficient binding of EpCAM(+) breast cancer cell lines SKBR-3, MCF-7, and MDA-MB-453, whereas anti-human EGFR MBs showed binding of EpCAM(LOW/NEGATIVE) cell lines MDA-MB-231 and BT-549...
October 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29079806/functionalization-of-microparticles-with-mineral-coatings-enhances-non-viral-transfection-of-primary-human-cells
#5
Andrew S Khalil, Xiaohua Yu, Angela W Xie, Gianluca Fontana, Jennifer M Umhoefer, Hunter J Johnson, Tracy A Hookway, Todd C McDevitt, William L Murphy
Gene delivery to primary human cells is a technology of critical interest to both life science research and therapeutic applications. However, poor efficiencies in gene transfer and undesirable safety profiles remain key limitations in advancing this technology. Here, we describe a materials-based approach whereby application of a bioresorbable mineral coating improves microparticle-based transfection of plasmid DNA lipoplexes in several primary human cell types. In the presence of these mineral-coated microparticles (MCMs), we observed up to 4-fold increases in transfection efficiency with simultaneous reductions in cytotoxicity...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29077718/effects-of-low-dose-x-ray-irradiation-on-activated-macrophages-and-their-possible-signal-pathways
#6
Jian Li, Zhen-Yu Yao, Chang She, Jian Li, Bin Ten, Chang Liu, Shu-Bin Lin, Qi-Rong Dong, Pei-Gen Ren
Low-dose irradiation (LDI) has been used in clinics to treat human diseases, including chronic inflammation. This study assessed the effects of LDI on the inflammatory response of activated mouse primary peritoneal macrophages, and the underlying signal pathways. Primary peritoneal macrophages were isolated from mice and then incubated with lipopolysaccharide (LPS)-coated Ti microparticles (Ti-positive control) with or without brief exposure to LDI (X-ray, 0.5 Gy) 1 h later (Ti-LDI group) or left untreated in culture medium (Ti-negative control)...
2017: PloS One
https://www.readbyqxmd.com/read/29031981/fabrication-and-characterization-of-gefitinib-releasing-polyurethane-foam-as-a-coating-for-drug-eluting-stent-in-the-treatment-of-bronchotracheal-cancer
#7
Weiluan Chen, Chiara di Carlo, Donal Devery, Donnacha J McGrath, Peter E McHugh, Kathrin Kleinsteinberg, Stefan Jockenhoevel, Wim E Hennink, Robbert J Kok
The purpose of the present study was to develop gefitinib-loaded polymeric foams that can be used as coating of drug-eluting stents for palliative treatment of bronchotracheal cancer. Release of such an anticancer drug from such stent coating can retard tumor regrowth into the bronchial lumen. Gefitinib-loaded polyurethane (PU) foams were prepared by embedding either gefitinib micronized crystals or gefitinib-loaded poly(lactic-co-glycolic acid) microspheres in water-blown films, with up to 10% w/w loading for gefitinib microcrystals and 15% w/w for gefitinib microspheres (corresponding to 1...
October 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29024311/collagen-inducing-biologization-of-prosthetic-material-for-hernia-repair-polypropylene-meshes-coated-with-polyp-collagen
#8
Maximilian Ackermann, Xiaohong Wang, Shunfeng Wang, Meik Neufurth, Heinz C Schröder, Friedrich-Eckart Isemer, Werner E G Müller
Prostethic mesh material such as nonabsorbable polypropylene used in open and laparoscopic hernia repair are characterized by controllable mechanical properties but may elicit undesirable physiological reactions due to the nonphysiological inert polymer material. We succeeded in developing a biocompatible coating for these meshes, based on a physiological inorganic polymer, polyphosphate (polyP) that is morphogenetically active and used as a metabolic energy source, and a collagen matrix. The polyP/collagen hydrogel material was prepared by a freeze-extraction method, with amorphous Ca-polyP microparticles...
October 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28991297/on-chip-polyelectrolyte-coating-onto-magnetic-droplets-towards-continuous-flow-assembly-of-drug-delivery-capsules
#9
Ali Q Alorabi, Mark D Tarn, Jenifer Gómez-Pastora, Eugenio Bringas, Inmaculada Ortiz, Vesselin N Paunov, Nicole Pamme
Polyelectrolyte (PE) microcapsules for drug delivery are typically fabricated via layer-by-layer (LbL) deposition of PE layers of alternating charge on sacrificial template microparticles, which usually requires multiple incubation and washing steps that render the process repetitive and time-consuming. Here, ferrofluid droplets were explored for this purpose as an elegant alternative of templates that can be easily manipulated via an external magnetic field, and require only a simple microfluidic chip design and setup...
November 7, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28969564/examining-insulin-adsorption-onto-mesoporous-silica-microparticles-for-oral-delivery
#10
Sarah Youssef Eilleia, Mahmoud Eid Soliman, Stefan Niedermayer, Alexandra Schmidt, Samar Mansour, Ahmed Shawky Geneidi
BACKGROUND: Microencapsulation is one of the most common techniques for the delivery of macromolecules; however, it can cause various stability problems, such as degradation or loss of bio-activity of the loaded molecules. For this reason, several techniques were investigated to load insulin into pre-formed porous microparticles (MPs). OBJECTIVE: The high loading of insulin is a prerequisite of its delivery in sufficient concentration; hence we examined insulin loading in mesoporous silica (SBA15-NH2) as a model for uniformly porous microparticles using different loading methods and factors...
October 2, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28966262/development-of-functional-thin-polymer-films-using-a-layer-by-layer-deposition-technique
#11
Kentaro Yoshida
Functional thin films containing insulin were prepared using layer-by-layer (LbL) deposition of insulin and negatively- or positively-charged polymers on the surface of solid substrates. LbL films composed of insulin and negatively-charged polymers such as poly(acrylic acid) (PAA), poly(vinylsulfate) (PVS), and dextran sulfate (DS) were prepared through electrostatic affinity between the materials. The insulin/PAA, insulin/PVS, and insulin/DS films were stable in acidic solutions, whereas they decomposed under physiological conditions as a result of a change in the net electric charge of insulin from positive to negative...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28905392/cryopreserved-platelets-demonstrate-reduced-activation-responses-and-impaired-signaling-after-agonist-stimulation
#12
Lauren Waters, Matthew P Padula, Denese C Marks, Lacey Johnson
BACKGROUND: Room temperature-stored (20-24°C) platelets (PLTs) have a shelf life of 5 days, making it logistically challenging to supply remote medical centers with PLT products. Cryopreservation of PLTs in dimethyl sulfoxide (DMSO) and storage at -80°C enables an extended shelf life up to 2 years. Although cryopreserved PLTs have been widely characterized under resting conditions, their ability to undergo agonist-induced activation is yet to be fully explored. STUDY DESIGN AND METHODS: Buffy coat PLTs were cryopreserved at -80°C with 5% to 6% DMSO and sampled before freezing and after thawing...
September 14, 2017: Transfusion
https://www.readbyqxmd.com/read/28898068/protein-mediated-colloidal-assembly
#13
Maiko Obana, Bradley R Silverman, David A Tirrell
Programmable colloidal assembly enables the creation of mesoscale materials in a bottom-up manner. Although DNA oligonucleotides have been used extensively as the programmable units in this paradigm, proteins, which exhibit more diverse modes of association and function, have not been widely used to direct colloidal assembly. Here we use protein-protein interactions to drive controlled aggregation of polystyrene microparticles, either through reversible coiled-coil interactions or through intermolecular isopeptide linkages...
October 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28893692/formation-of-mannitol-core-microparticles-for-sustained-release-with-lipid-coating-in-a-mini-fluid-bed-system
#14
Bifeng Wang, Wolfgang Friess
The goal of this study was to prepare sustained release microparticles for methyl blue and aspartame as sparingly and freely water-soluble model drugs by lipid film coating in a Mini-Glatt fluid bed, and to assess the effect of coating load of two of lipids, hard fat and glyceryl stearate, on the release rates. 30g drug-loaded mannitol carrier microparticles with average diameter of 500 or 300μm were coated with 5g, 10g, 20g and 30g lipids, respectively. The model drugs were completely released in vitro through pores which mainly resulted from dissolution of the polyol core beads...
November 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28822703/turning-the-screw-even-further-to-increase-microparticle-retention-and-ocular-bioavailability-of-associated-drugs-the-bioadhesion-goal
#15
J Rodríguez Villanueva, L Rodríguez Villanueva
Ocular drug delivery is one of the most fascinating and challenging tasks facing pharmaceutical researchers. Improving drug ocular residence time and/or penetration is complex. Microparticles (MP) provide interesting opportunities to increase ocular bioavailability of drugs and patient compliance brought about by decreased frequency of dosing. However, sustained-release microsphere formulation would fail to accomplish the task of long-lasting drug release unless microspheres remained for a prolonged period at the site of action...
August 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28818458/colonic-delivery-of-indometacin-loaded-pga-co-pdl-microparticles-coated-with-eudragit-l100-55-from-fast-disintegrating-tablets
#16
Hesham M Tawfeek, Ahmed A H Abdellatif, Thomas J Dennison, Afzal R Mohammed, Younis Sadiq, Imran Y Saleem
The aim of this work was to investigate the efficient targeting and delivery of indometacin (IND), as a model anti-inflammatory drug to the colon for treatment of inflammatory bowel disease. We prepared fast disintegrating tablets (FDT) containing IND encapsulated within poly(glycerol-adipate-co-ɷ-pentadecalactone), PGA-co-PDL, microparticles and coated with Eudragit L100-55 at different ratios (1:1.5, 1:1, 1:0.5). Microparticles encapsulated with IND were prepared using an o/w single emulsion solvent evaporation technique and coated with Eudragit L-100-55 via spray drying...
August 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28770528/quiescent-and-agitated-redispersion-as-a-tool-for-evaluating-dispersant-effectiveness-in-dissolution-enhancement-of-drug-laden-nanocomposites
#17
A Bhakay, R N Davé, E Bilgili
Nanocomposite microparticles (NCMPs) have been used in various solid dosage forms with the goal of enhancing the dissolution rate and bioavailability of poorly water-soluble drugs. Nanoparticle recovery from NCMPs, i.e., redispersion, is the preliminary step in drug dissolution. This study aims at exploring aqueous redispersion of NCMPs with various dispersants under quiescent vs. agitated conditions as potential dispersant screening tool in the development of fast-dissolving NCMP formulations. NCMPs were prepared by coating wet-milled suspensions of a poorly water-soluble drug, griseofulvin (GF), formulated with the dispersants hydroxypropyl cellulose (HPC), sodium dodecyl sulfate (SDS), as-received/wet co-milled croscarmellose sodium (CCS), and mannitol, onto Pharmatose® carrier particles in a fluidized bed dryer...
August 2, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28732440/intravenous-injection-of-myelin-oligodendrocyte-glycoprotein-coated-plga-microparticles-have-tolerogenic-effects-in-experimental-autoimmune-encephalomyelitis
#18
Mehrdad Gholamzad, Masoumeh Ebtekar, Mehdi Shafiee Ardestani
The abnormal function of the T lymphocytes causes a range of autoimmune diseases, particularly multiple sclerosis; hence, several methods have been used to treat these disorders through the induction of antigen-specific tolerance in T cells. The present study aims to use a simple and low-cost method to produce poly (lactic-co-glycolic acid) (PLGA) nanoparticles for carrying antigens and inducing antigen-specific tolerance. In this study, PLGA nanoparticles were produced using the water/oil/water (W/O/W) method...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28726381/impact-of-the-metallic-crystalline-structure-on-the-properties-of-nanocrystals-and-their-mesoscopic-assemblies
#19
Marie-Paule Pileni
The spontaneous assembly of uniform-sized globular entities into ordered arrays is a universal phenomenon observed for objects with diameters spanning a broad range of length scales. These extend from the atomic scale (10(-8) cm), through molecular and macromolecular scales with proteins, synthetic low polymers, and colloidal crystals (∼10(-6) cm), to the wavelength of visible light (∼10(-5) cm). The associated concepts of sphere packing have had an influence in diverse fields ranging from pure geometrical analysis to architectural models or ideals...
July 20, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28726349/aspherical-nanostructured-microparticles-for-targeted-gene-delivery-to-alveolar-macrophages
#20
Michael Möhwald, Shashank Reddy Pinnapireddy, Bodo Wonnenberg, Marcel Pourasghar, Marijas Jurisic, Andrea Jung, Claudia Fink-Straube, Thomas Tschernig, Udo Bakowsky, Marc Schneider
Introducing novel shapes to particulate carrier systems adds unique features to modern drug and gene delivery. Depending on the route of administration, particle geometry can influence deposition and fate within biological environments. In this work, a template-assisted engineering technique is applied, providing full control of size and shape in the preparation of aspherical, nanostructured microparticles. Based on the interconnection of nanoparticles, stabilized by a functional layer-by-layer (LbL) coating, the resulting cylindrical micrometer architecture is especially qualified for pulmonary delivery...
July 20, 2017: Advanced Healthcare Materials
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