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https://www.readbyqxmd.com/read/28231047/original-research-paper-characterization-and-taste-masking-evaluation-of-microparticles-with-cetirizine-dihydrochloride-and-methacrylate-based-copolymer-obtained-by-spray-drying
#1
Aleksandra Amelian, Marta Szekalska, Patrycja Ciosek, Anna Basa, Katarzyna Winnicka
Taste of a pharmaceutical formulation is an important parameter for the effectiveness of pharmacotherapy. Cetirizine dihydrochloride (CET) is a second-generation antihistamine that is commonly administered in allergy treatment. CET is characterized by extremely bitter taste and it is a great challenge to successfully mask its taste; therefore the goal of this work was to formulate and characterize the microparticles obtained by the spray drying method with CET and poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 copolymer (Eudragit E PO) as a barrier coating...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28222020/high-dose-biotin-therapy-leading-to-false-biochemical-endocrine-profiles-validation-of-a-simple-method-to-overcome-biotin-interference
#2
Marie-Liesse Piketty, Dominique Prie, Frederic Sedel, Delphine Bernard, Claude Hercend, Philippe Chanson, Jean-Claude Souberbielle
BACKGROUND: High-dose biotin therapy is beneficial in progressive multiple sclerosis (MS) and is expected to be adopted by a large number of patients. Biotin therapy leads to analytical interference in many immunoassays that utilize streptavidin-biotin capture techniques, yielding skewed results that can mimic various endocrine disorders. We aimed at exploring this interference, to be able to remove biotin and avoid misleading results. METHODS: We measured free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), parathyroid homrone (PTH), 25-hydroxyvitamin D (25OHD), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, C-peptide, cortisol (Roche Diagnostics assays), biotin and its main metabolites (liquid chromatography tandem mass spectrometry) in 23 plasmas from MS patients and healthy volunteers receiving high-dose biotin, and in 39 biotin-unsupplemented patients, before and after a simple procedure (designated N5) designed to remove biotin by means of streptavidin-coated microparticles...
February 21, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28211454/harnessing-catalytic-pumps-for-directional-delivery-of-microparticles-in-microchambers
#3
Sambeeta Das, Oleg E Shklyaev, Alicia Altemose, Henry Shum, Isamar Ortiz-Rivera, Lyanne Valdez, Thomas E Mallouk, Anna C Balazs, Ayusman Sen
The directed transport of microparticles in microfluidic devices is vital for efficient bioassays and fabrication of complex microstructures. There remains, however, a need for methods to propel and steer microscopic cargo that do not require modifying these particles. Using theory and experiments, we show that catalytic surface reactions can be used to deliver microparticle cargo to specified regions in microchambers. Here reagents diffuse from a gel reservoir and react with the catalyst-coated surface. Fluid density gradients due to the spatially varying reagent concentration induce a convective flow, which carries the suspended particles until the reagents are consumed...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28179159/in-vivo-osteogenic-differentiation-of-stem-cells-inside-compartmentalized-capsules-loaded-with-co-cultured-endothelial-cells
#4
Clara R Correia, Tírcia C Santos, Rogério P Pirraco, Mariana T Cerqueira, Alexandra P Marques, Rui L Reis, João F Mano
: Capsules coated with polyelectrolytes and co-encapsulating adipose stem (ASCs) and endothelial (ECs) cells with surface modified microparticles are developed. Microparticles and cells are freely dispersed in a liquified core, responsible to maximize the diffusion of essential molecules and allowing the geometrical freedom for the autonomous three-dimensional (3D) organization of cells. While the membrane wraps all the instructive cargo elements within a single structure, the microparticles provide a solid 3D substrate for the encapsulated cells...
February 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28138910/spray-dried-thiolated-chitosan-coated-sodium-alginate-multilayer-microparticles-for-vaginal-hiv-microbicide-delivery
#5
Jianing Meng, Vivek Agrahari, Miezan J Ezoulin, Sudhaunshu S Purohit, Tao Zhang, Agostino Molteni, Daniel Dim, Nathan A Oyler, Bi-Botti C Youan
It is hypothesized that novel thiolated chitosan-coated multilayer microparticles (MPs) with enhanced drug loading are more mucoadhesive than uncoated MPs and safe in vivo for vaginal delivery of topical anti-HIV microbicide. Formulation optimization is achieved through a custom experimental design and the alginate (AG) MPs cores are prepared using the spray drying method. The optimal MPs are then coated with the thiolated chitosan (TCS) using a layer-by-layer method. The morphological analysis, in situ drug payload, in vitro drug release profile, and mucoadhesion potential of the MPs are carried out using scanning electron microscopy, solid-state (31)P NMR spectroscopy, UV spectroscopy, fluorescence imaging and periodic acid Schiff method, respectively...
January 30, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28134392/chitosan-based-water-propelled-micromotors-with-strong-antibacterial-activity
#6
Jorge A M Delezuk, Doris E Ramírez-Herrera, Berta Esteban-Fernández de Ávila, Joseph Wang
A rapid and efficient micromotor-based bacteria killing strategy is described. The new antibacterial approach couples the attractive antibacterial properties of chitosan with the efficient water-powered propulsion of magnesium (Mg) micromotors. These Janus micromotors consist of Mg microparticles coated with the biodegradable and biocompatible polymers poly(lactic-co-glycolic acid) (PLGA), alginate (Alg) and chitosan (Chi), with the latter responsible for the antibacterial properties of the micromotor. The distinct speed and efficiency advantages of the new micromotor-based environmentally friendly antibacterial approach have been demonstrated in various control experiments by treating drinking water contaminated with model Escherichia coli (E...
January 30, 2017: Nanoscale
https://www.readbyqxmd.com/read/28112416/isomotive-dielectrophoresis-isodep-for-parallel-analysis-of-individual-particles
#7
Daniel J Allen, Robert P Accolla, Stuart J Williams
Two dielectrophoresis systems are introduced where the induced dielectrophoretic force is constant throughout the experimental region, resulting in uniform (isomotive) microparticle translation. Isomotive dielectrophoresis (isoDEP) is accomplished through a unique geometry where the gradient of the field-squared (∇Erms2) is constant, a characteristic that is otherwise highly non-uniform in traditional DEP platforms. The governing isoDEP equations were derived herein and applied to two different isoDEP prototypes: (i) one fabricated from deep reactive ion etching (DRIE) of a conductive silicon wafer (1-10 Ω-cm) whose patterned features served as electrodes and microchannel sidewalls simultaneously; (ii) a second where the electric field is applied lengthwise through a PDMS microchannel whose geometry follows a specific curvature...
January 23, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28111317/transplantation-of-adipose-derived-stem-cells-combined-with-neuregulin-microparticles-promotes-efficient-cardiac-repair-in-a-rat-myocardial-infarction-model
#8
Paula Díaz-Herráez, Laura Saludas, Simón Pascual-Gil, Teresa Simón-Yarza, Gloria Abizanda, Felipe Prósper, Elisa Garbayo, María José Blanco-Prieto
Tissue engineering is a promising strategy to promote heart regeneration after a myocardial infarction (MI). In this study, we investigated the reparative potential of a system that combines adipose-derived stem cells (ADSCs) with microparticles (MPs) loaded with neuregulin (NRG), named ADSC-NRG-MPs, on a rat MI model. First, cells were attached to the surface of MPs encapsulating NRG and coated with a 1:1 mixture of collagen and poly-d-lysine. One week after in vivo administration, the system favored the shift of macrophage expression from a pro-inflammatory to a regenerative phenotype...
January 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28111281/aerosolizable-gold-nano-in-micro-dry-powder-formulations-for-theragnosis-and-lung-delivery
#9
A Sofia Silva, Ana M Sousa, Renato P Cabral, Marta C Silva, Clarinda Costa, Sónia P Miguel, Vasco D B Bonifácio, Teresa Casimiro, Ilídio J Correia, Ana Aguiar-Ricardo
Functionalized gold nanoparticles (AuNPs) have been widely investigated as promising multifunctional nanosystems for the theragnosis of lung cancer, the most common and prominent cause of cancer death worldwide. Nevertheless, nanoparticles are not in appropriate sizes for an accurate deep lung delivery and the lack of locally and effective delivery of therapeutic biomolecules to the deep lungs is, in fact, the major cause of low therapeutic outcome. Herein we incorporate, for the first time, AuNPs into respirable microparticles...
January 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28071591/high-throughput-micropatterning-of-interspersed-cell-arrays-using-capillary-assembly
#10
François-Damien Delapierre, Guillaume Mottet, Vélan Taniga, Julie Boisselier, Jean-Louis Viovy, Laurent Malaquin
A novel technology is reported to immobilize different types of particles or cells on a surface at predefined positions with a micrometric precision. The process uses capillary assembly on arrays of crescent-shaped structures with different orientations. Sequential assemblies in different substrate orientations with different types of particles allow for the creation of imbricated and multiplexed arrays. In this work up to four different types of particles were deterministically localized on a surface. Using this process, antibody coated microparticles were assembled on substrates and used as capture patterns for the creation of complex cell networks...
February 6, 2017: Biofabrication
https://www.readbyqxmd.com/read/28063041/particle-bombardment-of-ex-vivo-skin-to-deliver-dna-and-express-proteins
#11
Ena Sokol, Miranda Nijenhuis, Klaas A Sjollema, Marcel F Jonkman, Hendri H Pas, Ben N G Giepmans
Particle bombardment of gold microparticles coated with plasmids, which are accelerated to high velocity, is used for transfection of cells within tissue. Using this method, cDNA encoding proteins of interest introduced into ex vivo living human skin enables studying of proteins of interest in real time. Here, technical aspects of particle bombardment of ex vivo skin are described using green fluorescent protein (GFP) as readout for efficiency. This method can be applied on numerous tissues, including in living model animals...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28054333/bmp-2-coated-mineral-coated-microparticles-improve-bone-repair-in-atrophic-non-unions
#12
M Orth, N J Kruse, B J Braun, C Scheuer, J H Holstein, A Khalil, X Yu, W L Murphy, T Pohlemann, M W Laschke, M D Menger
Atrophic non-unions are a major clinical problem. Mineral coated microparticles (MCM) are electrolyte-coated hydroxyapatite particles that have been shown in vitro to bind growth factors electrostatically and enable a tuneable sustained release. Herein, we studied whether MCM can be used in vivo to apply Bone Morphogenetic Protein-2 (BMP-2) to improve bone repair of atrophic non-unions. For this purpose, atrophic non-unions were induced in femurs of CD-1 mice (n = 48). Animals either received BMP-2-coated MCM (MCM + BMP; n = 16), uncoated MCM (MCM; n = 16) or no MCM (NONE; n = 16)...
January 2, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28034735/hydrophilic-drug-encapsulation-in-shell-core-microcarriers-by-two-stage-polyelectrolyte-complexation-method
#13
Annalisa Dalmoro, Alexander Y Sitenkov, Sara Cascone, Gaetano Lamberti, Anna Angela Barba, Rouslan I Moustafine
In this study a protocol exploiting the combination of the ultrasonic atomization and the complexation between polyelectrolytes was developed to efficiently encapsulate a hydrophilic chemotherapeutic agent essentially used in the treatment of colon cancer, 5-fluorouracil, in enteric shell-core alginate-based microcarriers. The atomization assisted by ultrasound allowed to obtain small droplets by supplying low energy and avoiding drug degradation. In particular microcarriers were produced in a home-made apparatus where both the core (composed of alginate, drug, and Pluronic F127) and shell (composed of only alginate) feed were separately sent to the coaxial ultrasonic atomizer where they were nebulized and placed in contact with the complexation bulk...
December 26, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28029568/differences-in-levels-of-platelet-derived-microparticles-in-platelet-components-prepared-using-the-platelet-rich-plasma-buffy-coat-and-apheresis-procedures
#14
Egarit Noulsri, Prapaporn Udomwinijsilp, Surada Lerdwana, Viroje Chongkolwatana, Parichart Permpikul
BACKGROUND: There has been an increased interest in platelet-derived microparticles (PMPs) in transfusion medicine. Little is known about PMP status during the preparation of platelet concentrates for transfusion. AIM: The aim of this study is to compare the PMP levels in platelet components prepared using the buffy coat (BC), platelet-rich plasma platelet concentrate (PRP-PC), and apheresis (AP) processes. METHODS: Platelet components were prepared using the PRP-PC and BC processes...
October 25, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28005334/design-of-uv-absorbing-polypropylene-films-with-polymeric-benzotriaziole-based-nano-and-microparticle-coatings
#15
Sarit Cohen, Hai Haham, Michal Pellach, Shlomo Margel
UV-absorbing nanoparticles (NPs) and microparticles (MPs) were prepared by emulsion and dispersion copolymerization of the vinylic monomer 2-(2'-hydroxy-5'-methacryloxyethylphenyl)-2H-benzotriazole (Norbloc (NB)) with the crosslinking monomer divinylbenzene. The effect of the initiator concentration on the size and size distribution of the polyNB (PNB) particles was elucidated. Thin coatings of the formed PNB NPs or MPs of 19 ± 2 and 200 ± 25 nm dry diameter, respectively, onto polypropylene (PP) films were then prepared and characterized...
December 22, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27988326/everolimus-tdm-using-thermo-fisher-qms-immunoassay-on-indiko-beckman-dxc-au680-and-au5800-analyzers
#16
Steven Hy Wong, Kamisha L Johnson-Davis, Krista Garrison, Joe D Rankin, Chro S Muhammad
OBJECTIVES: Everolimus (EVR), a mTOR inhibitor immunosuppressant approved for renal, liver and cardiac transplants. This study established the appropriate TDM performances of the Thermo Scientific QMS EVR Assay by using the Beckman DxC, followed by comparison to the Thermo Scientific Indiko and a previously published LC-MS/MS assay, and Beckman AU680 and AU5800 analyzers. DESIGN AND METHODS: The study initially established acceptable linearity, precision and accuracy of the QMS EVR turbidimetric assay...
December 15, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27966176/design-of-magnetic-polymeric-particles-as-a-stimulus-responsive-system-for-gastric-antimicrobial-therapy
#17
Erica L Silva-Freitas, Thales R F Pontes, Rafael P Araújo-Neto, Ítalo H M Damasceno, Kátia L Silva, Juliana F Carvalho, Aldo C Medeiros, Rodolfo B Silva, Amanda K A Silva, Marco A Morales, Eryvaldo S T Egito, Ana L Dantas, Artur S Carriço
The treatment of peptic ulcers induced by H. pylori remains challenging due to the deep mucous layer location of bacteria preventing antimicrobial drug access. The present work aimed to design and evaluate in vitro dual responsive (both pH and magnetic field-sensitive) polymeric magnetic particles loaded with amoxicillin as a smart drug carrier for deep mucous layer penetration and in situ drug release. Magnetite particles were produced by the co-precipitation method and subsequently coated with the Eudragit(®)S100 and amoxicillin by using the spray-drying technique...
December 13, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27936586/inspired-by-stenocara-beetles-from-water-collection-to-high-efficiency-water-in-oil-emulsion-separation
#18
Xinjuan Zeng, Long Qian, Xianxia Yuan, Cailong Zhou, Zhaowen Li, Jiang Cheng, Shouping Xu, Shuangfeng Wang, Pihui Pi, Xiufang Wen
Inspired by the water-collecting mechanism of the Stenocara beetle's back structure, we prepared a superhydrophilic bumps-superhydrophobic/superoleophilic stainless steel mesh (SBS-SSM) filter via a facile and environmentally friendly method. Specifically, hydrophilic silica microparticles are assembled on the as-cleaned stainless steel mesh surface, followed by further spin-coating with a fluoropolymer/SiO2 nanoparticle solution. On the special surface of SBS-SSM, attributed to the steep surface energy gradient, the superhydrophilic bumps (hydrophilic silica microparticles) are able to capture emulsified water droplets and collect water from the emulsion even when their size is smaller than the pore size of the stainless steel mesh...
December 12, 2016: ACS Nano
https://www.readbyqxmd.com/read/27889559/plasma-endothelial-microparticles-reflect-the-extent-of-capillaroscopic-alterations-and-correlate-with-the-severity-of-skin-involvement-in-systemic-sclerosis
#19
Małgorzata Michalska-Jakubus, Otylia Kowal-Bielecka, Vanessa Smith, Maurizio Cutolo, Dorota Krasowska
INTRODUCTION AND AIM: Endothelial microparticles (EMPs) are membrane-coated vesicles shed from endothelial cells and are considered markers of the endothelial state. It has been shown that total numbers of circulating EMPs are increased in patients with systemic sclerosis (SSc), but their clinical correlations have not yet been investigated in detail. We aimed to assess possible relationships between circulating EMPs and clinical as well as laboratory features among SSc patients with special attention to possible association with alteration in microvascular morphology objectified on nailfold videocapillaroscopy and clinical signs of microvascular complications...
November 23, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27878196/self-propelled-round-trip-motion-of-janus-particles-in-static-line-optical-tweezers
#20
Jing Liu, Hong-Lian Guo, Zhi-Yuan Li
Controlled propulsion of microparticles and micromachines in fluids could revolutionize many aspects of technology, such as biomedicine, microfluidics, micro-mechanics, optomechanics, and cell biology. We report the self-propelled cyclic round-trip motion of metallo-dielectric Janus particles in static line optical tweezers (LOT). The Janus particle is a 5 μm-diameter polystyrene sphere half-coated with 3 nanometer thick gold film. Both experiment and theory show that this cyclic translational and rotational motion is a consequence of the collective and fine action of the gold-face orientation dependent propulsion optical force, the gradient optical force, and the spontaneous symmetry breaking induced optical torque in different regions of the LOT...
December 1, 2016: Nanoscale
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