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microparticle coating

Małgorzata Michalska-Jakubus, Otylia Kowal-Bielecka, Vanessa Smith, Maurizio Cutolo, Dorota Krasowska
INTRODUCTION AND AIM: Endothelial microparticles (EMPs) are membrane-coated vesicles shed from endothelial cells and are considered markers of the endothelial state. It has been shown that total numbers of circulating EMPs are increased in patients with systemic sclerosis (SSc), but their clinical correlations have not yet been investigated in detail. We aimed to assess possible relationships between circulating EMPs and clinical as well as laboratory features among SSc patients with special attention to possible association with alteration in microvascular morphology objectified on nailfold videocapillaroscopy and clinical signs of microvascular complications...
November 23, 2016: Microvascular Research
Jing Liu, Hong-Lian Guo, Zhi-Yuan Li
Controlled propulsion of microparticles and micromachines in fluids could revolutionize many aspects of technology, such as biomedicine, microfluidics, micro-mechanics, optomechanics, and cell biology. We report the self-propelled cyclic round-trip motion of metallo-dielectric Janus particles in static line optical tweezers (LOT). The Janus particle is a 5 μm-diameter polystyrene sphere half-coated with 3 nanometer thick gold film. Both experiment and theory show that this cyclic translational and rotational motion is a consequence of the collective and fine action of the gold-face orientation dependent propulsion optical force, the gradient optical force, and the spontaneous symmetry breaking induced optical torque in different regions of the LOT...
December 1, 2016: Nanoscale
Chia-Wen Tsao, Yueh-Pu Lee
In this study, an iron oxide magnetic microparticles and poly(dimethylsiloxane) (MMPs-PDMS) composite material was employed to demonstrate a simple high-strength reversible magnetic bonding method. This paper presents the casting of opaque-view (where optical inspection through the microchannels was impossible) and clear-view (where optical inspection through the microchannel was possible) MMPs-PDMS. The influence of the microchannel geometries on the casting of the opaque-view casting was limited, which is similar to standard PDMS casting...
2016: Science and Technology of Advanced Materials
Han-Joo Yang, Pei Sia Lee, Jaehyeog Choe, Seokjin Suh, Sanghoon Ko
Chitosan (CS) was grafted with 0.1 and 0.5% (w/v) palmitic acid (PA) to improve its encapsulation efficiency (EE) and sustained release characteristics when forming CS microparticles. Thereafter, PA-grafted CS (PA-CS) microparticles were coated with denatured β-lactoglobulin (βlg), which forms an outer protective layer. The possibility of hydrophobic interaction with the hydrophobic substances in the CS microparticles increased as the proportion of the grafted PA increased. EE was measured as 64.79, 83.72, and 85...
April 1, 2017: Food Chemistry
Bugra Ayan, Adem Ozcelik, Hunter Bachman, Shi-Yang Tang, Yuliang Xie, Mengxi Wu, Peng Li, Tony Jun Huang
On-chip microparticle and cell coating technologies enable a myriad of applications in chemistry, engineering, and medicine. Current microfluidic coating technologies often rely on magnetic labeling and concurrent deflection of particles across laminar streams of chemicals. Herein, we introduce an acoustofluidic approach for microparticle and cell coating by implementing tilted-angle standing surface acoustic waves (taSSAWs) into microchannels with multiple inlets. The primary acoustic radiation force generated by the taSSAW field was exploited in order to migrate the particles across the microchannel through multiple laminar streams, which contained the buffer and coating chemicals...
October 18, 2016: Lab on a Chip
Woo Jin Lee, Sang Woo Han, Insang You, Song-Ee Choi, Unyong Jeong, Jin Woong Kim
A robust and straightforward approach for fabrication of a new type of colloidal pressure sensor was proposed. For this purpose, we synthesized uniform conductive magnetic-patchy microparticles using a microfluidic technique and then coated them with poly(3,4-ethylene dioxythiophene)-poly(styrene sulfonate) layers using the layer-by-layer deposition. Finally we showed that the magnetic-patchy conductive microparticles could be positioned on the target sites while precisely detecting pressure changes with excellent sensitivity...
October 11, 2016: Chemical Communications: Chem Comm
Hamad Alyami, Jasdip Koner, Eman Z Dahmash, James Bowen, David Terry, Afzal R Mohammed
OBJECTIVES: The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs). METHODS: The moisture content of MCC was optimised using the spray water method and analysed using thermogravimetric analysis. Microproperty/macroproperty assessment was investigated using atomic force microscopy, nano-indentation, scanning electron microscopy, tablet hardness and disintegration testing...
October 2, 2016: Journal of Pharmacy and Pharmacology
Geneviève Marcoux, Anne-Claire Duchez, Matthieu Rousseau, Tania Lévesque, Luc H Boudreau, Louis Thibault, Eric Boilard
On activation, platelets release vesicles called microparticles (MPs). MPs are heterogeneous with regard to the presence or absence of mitochondria. We quantified MPs in platelet concentrates (PCs) taking their mitochondrial content into account. Platelet-rich plasma (PRP), buffy coat (BC) and apheresis (AP) PCs were tested through 7 days of storage. A combination of flow cytometry and spanning-tree progression analysis of density-normalized events (SPADE) was used to determine MP and mitochondrial release during storage...
September 29, 2016: Platelets
Kunsuk Koh, Hyejin Hwang, Choojin Park, Jae Yong Lee, Tae Yoon Jeon, Shin-Hyun Kim, Jin Kon Kim, Unyong Jeong
This work introduces a robust means for excellent position registry of microparticles via a forced assembly technique on flexible or stretchable substrates. It is based on the dry powder rubbing process which allows assembly of a microparticle monolayer in a short time without requiring any solvent or thermal treatment. Elastic physical templates are used as substrates for the forced assembly in this study. Since the elastic templates can reduce the stress accumulation between the closely packed particles, they can minimize the defect formation in the particle assembly in large areas...
October 4, 2016: ACS Applied Materials & Interfaces
Hiraku Onishi, Ayako Tokuyasu
BACKGROUND: The production of protein drugs has recently increased due to advances in biotechnology, but their clinical use is generally limited to parenteral administration due to low absorption in non-parenteral administration. Therefore, non-parenteral delivery systems allowing sufficient absorption draw much attention. METHODS: Microparticles (MP) were prepared using chitosan-4-thio-butylamidine conjugate (Ch-TBA), trimethyl-chitosan (TMC), and chitosan (Ch)...
2016: International Journal of Molecular Sciences
Yong Zhang, Lili Cui, Feng Li, Nianqiu Shi, Chunlei Li, Xianghui Yu, Yan Chen, Wei Kong
Nano/micro-carrier systems have shown promising application in the biomedical field as various delivery carriers. The composite material and fabrication method determine their microstructures, properties and thus their potential applications. Since approved as tablet coating material by the U.S. Food and Drug Administration (US-FDA), zein has been widely investigated as one of protein-based materials in the past few decades. Zein is renewable, biodegradable and relatively inexpensive in comparison with animal proteins (e...
September 9, 2016: International Journal of Pharmaceutics
Ze Li, Fangfang Xiong, Jintian He, Xiaojing Dai, Gaizhen Wang
In the present study, surface-functionalized, pH-responsive poly(lactic-co-glycolic acid) (PLGA) microparticles were investigated for nasal delivery of hepatitis B surface Antigen (HBsAg). pH-responsive PLGA, chitosan modified PLGA (CS-PLGA), mannan modified PLGA (MN-PLGA), mannan and chitosan co-modified PLGA (MN-CS-PLGA) microparticles were prepared utilizing a double-emulsion method. Antigen was released rapidly from four types of microparticles at pH5.0 and pH 6.0, but slowly released at pH 7.4. Mannan and chitosan surface modification enhanced intracellular microparticle uptake by macrophages...
December 2016: European Journal of Pharmaceutics and Biopharmaceutics
Maria S Savelyeva, Anatoly A Abalymov, German P Lyubun, Irina V Vidyasheva, Alexey M Yashchenok, Timothy E L Douglas, Dmitry A Gorin, Bogdan V Parakhonskiy
The process of porous calcium carbonate (CaCO3 ) covering on electrospun poly(ε-caprolactone) (PCL) fibers is described in this study. Uniform CaCO3 coatings, composed of vaterite microparticles and its aggregates, were formed on PCL fibers by mineral precipitation from solution under ultrasonic treatment. The porous structure of CaCO3 in vaterite polymorphic form is useful for loading of various substances (drugs and nanoparticles), and this property makes vaterite an appropriate material for design of drug delivery systems...
January 2017: Journal of Biomedical Materials Research. Part A
Bhuvnesh Bharti, Florian Kogler, Carol K Hall, Sabine H L Klapp, Orlin D Velev
Dipolar interactions between nano- and micron sized colloids lead to their assembly into domains with well-defined local order. The particles with a single dipole induced by an external field assemble into linear chains and clusters. However, to achieve the formation of multidirectionally organized nano- or microassemblies with tunable physical characteristics, more sophisticated interaction tools are needed. Here we demonstrate that such complex interactions can be introduced in the form of two independent, non-interacting dipoles (double-dipoles) within a microparticle...
October 7, 2016: Soft Matter
Daryl Crimmins, Peter Flanagan, Richard Charlewood, Katya Ruggiero
BACKGROUND: Cryopreserved platelet (PLT) components stored at -80°C in 5% to 6% dimethyl sulfoxide (DMSO) demonstrate enhanced hemostatic activity. Alterations in PLT surface glycoprotein expression and release of procoagulant microparticles during the freeze/thaw cycle result in PLT activation. Nothing is known of the effect of gamma irradiation on the in vitro quality of reconstituted cryopreserved PLTs. STUDY DESIGN AND METHODS: Gamma-irradiated (25-50 Gy) buffy coat-derived PLT components were either stored at room temperature for 7 days (the current expiry in New Zealand) or cryopreserved at -80°C using 5% to 6% DMSO...
August 16, 2016: Transfusion
M R Kaizer, J R Almeida, A P R Gonçalves, Y Zhang, S S Cava, R R Moraes
This study was designed to develop and characterize a silica-coating method for crystalline nonsilicate ceramic nanoparticles (Al2O3, TiO2, and ZrO2). The hypothesis was that the coated nonsilicate nanoparticles would stably reinforce a polymeric matrix due to effective silanation. Silica coating was applied via a sol-gel method, with tetraethyl orthosilicate as a silica precursor, followed by heat treatment. The chemical and microstructural characteristics of the nanopowders were evaluated before and after silica coating through x-ray diffraction, BET (Brunauer-Emmett-Teller), energy-dispersive x-ray spectroscopy, field emission scanning electron microscopy, and transmission electron microscopy analyses...
July 28, 2016: Journal of Dental Research
Liangcai Xie, Wenli Cheng, Lei Xu, Wen Fan, Yirong Li
BACKGROUND: Rheumatoid factor (RF) can interfere both positively and negatively in immunoassays. It remains unclear whether the negative interference is an exceptional phenomenon or a denominator of immunoassays and which RF subgroup plays a key role in its causation. METHODS: Serum models comprising hepatitis B envelope antigen (HBeAg) and RF were made by blending HBeAg-positive sera and RF-positive sera at a ratio of 1:9. Paramagnetic microparticles coated with P human chorionic gonadotropin (betaHCG)-anti-betaHCG complexes were used to remove RFs from the models, and HBeAg was determined in models using the chemiluminescent microparticle immunoassay (CMIA)...
2016: Clinical Laboratory
Khurram Shezad, Kejun Zhang, Mubashir Hussain, Hai Dong, Chuanxin He, Xiangjun Gong, Xiaolin Xie, Jintao Zhu, Lei Shen
The presence of surfaces influences the kinetics of amyloid-β (Aβ) peptide fibrillation. Although it has been generally recognized that the fibrillation process can be assisted or accelerated by surface chemistry, the impact of surface topography, i.e., roughness, on peptide fibrillation is relatively little understood. Here we study the role of surface roughness on surface-mediated fibrillation using polymer coatings of varying roughness as well as polymer microparticles. Using single-molecule tracking, atomic force microscopy, and the thioflavin T fluorescence technique, we show that a rough surface decelerates the two-dimensional (2D) diffusion of peptides and retards the surface-mediated fibrillation...
August 16, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Xing Zhou, Yang Zhao, Siyu Chen, Songling Han, Xiaoqiu Xu, Jiawei Guo, Mengyu Liu, Ling Che, Xiaohui Li, Jianxiang Zhang
Targeted delivery of therapeutics to the intestine is preferred for the management of many diseases due to its diverse advantages. Currently, there are still challenges in creating cost-effective and translational pH-responsive microspheres for intestinal delivery of various hydrophobic drugs. Herein we report a multiple noncovalent interactions-mediated assembly strategy in which carboxyl-bearing compounds (CBCs) are guest molecules, while poly(N-isopropylacrylamide) (PNIPAm) serves as a host polymer. Formation of microparticles and therapeutic packaging can be achieved simultaneously by this assembly approach, leading to well-shaped microspheres with extremely higher drug loading capacity as compared to microspheres based on two FDA-approved materials of poly(d,l-lactide-co-glycolide) (PLGA) and an enteric coating polymer EudragitS 100 (S100)...
August 8, 2016: Biomacromolecules
Lei Jin, Yi-Cun Ding, Yu Zhang, Xiao-Qing Xu, Qin Cao
The aim of the present study was to design a new pH-enzyme double-dependent mesalamine colon-specific delivery system. The drug release behaviors in vitro and pharmacokinetics and biodistribution in vivo were further evaluated. The mean particle diameters of mesalamine-coated microparticles were 312.2 µm. In vitro, a small amount of mesalamine was released in HCl at a pH of 1.2 and PBS medium at a pH of 7.4 for 5 hours, and 71% of the entrapped mesalamine was further released during the subsequent 20 hours of incubation...
2016: Drug Design, Development and Therapy
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