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https://www.readbyqxmd.com/read/28938493/acute-and-chronic-impact-of-bariatric-surgery-on-plasma-ldl-cholesterol-and-pcsk9-levels-in-patients-with-severe-obesity
#1
Marjorie Boyer, Marie-Eve Piché, Audrey Auclair, Thomas Grenier-Larouche, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Simon Biron, Stéfane Lebel, Odette Lescelleur, François Julien, Julie Martin, André Tchernof, André C Carpentier, Paul Poirier, Benoit J Arsenault
Context: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein cholesterol (LDL-C) concentrations. In patients with severe obesity, biliopancreatic diversion with duodenal switch (BPD-DS) surgery induces substantial weight loss and favourably influence lipoprotein metabolism. The impact of BPD-DS surgery on PCSK9 levels is unknown. Objectives: To determine the acute and chronic impact of BPD-DS surgery on PCSK9 levels and whether the acute impact of BPD-DS could be explained by BPD-DS surgery-associated caloric restriction (CR)...
August 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938270/bariatric-surgery-and-the-risk-of-cancer-in-a-large-multisite-cohort
#2
Daniel P Schauer, Heather Spencer Feigelson, Corinna Koebnick, Bette Caan, Sheila Weinmann, Anthony C Leonard, J David Powers, Panduranga R Yenumula, David E Arterburn
OBJECTIVE: To determine whether bariatric surgery is associated with a lower risk of cancer. BACKGROUND: Obesity is strongly associated with many types of cancer. Few studies have examined the relationship between bariatric surgery and cancer risk. METHODS: We conducted a retrospective cohort study of patients undergoing bariatric surgery between 2005 and 2012 with follow-up through 2014 using data from a large integrated health insurance and care delivery systems with 5 study sites...
September 21, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28936585/understanding-intestinal-glucose-transporter-expression-in-obese-compared-to-non-obese-subjects
#3
Rebecca A Deal, Yueming Tang, Reid Fletcher, Alfonso Torquati, Philip Omotosho
INTRODUCTION: The impact of Roux-en-Y gastric bypass (RYGB) on weight loss and co-morbid disease resolution is well established. However, the mechanisms underlying the procedure remain incompletely understood. Intestinal remodeling involving glucose transporters (GLUTs) may play a crucial role. Rat studies have demonstrated morphological adaptation of GLUTs within adipose and intestinal cells in association with the reprogramming of glucose metabolism. There is a limited understanding of the variations in expression amongst GLUT family receptors in the human intestine...
September 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28936562/can-a-laparoscopic-roux-en-y-gastric-bypass-be-safely-performed-by-surgical-residents-in-a-bariatric-center-of-excellence-the-learning-curve-of-surgical-residents-in-bariatric-surgery
#4
Anne-Sophie van Rijswijk, Daan E Moes, Noëlle Geubbels, Barbara A Hutten, Yair I Z Acherman, Arnold W van de Laar, Maurits de Brauw, Sjoerd C Bruin
BACKGROUND: A learning curve (LC) is a graphic display of the number of consecutive procedures performed necessary to reach competence and is defined by complications and duration of surgery (DOS). There is little evidence on the LC of surgical residents in bariatric surgery. Aim of the study is to evaluate whether the laparoscopic Roux-en-Y gastric bypass (LRYGB) can be safely performed by surgical residents, to evaluate the LC of surgical residents for LRYGB and to assess whether surgical residents fit in the LC of the bariatric center which has been established by their proctors...
September 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28935201/gastric-pouch-emptying-of-solid-food-in-patients-with-successful-and-unsuccessful-weight-loss-after-roux-en-y-gastric-bypass-surgery
#5
Laura N Deden, Mellody I Cooiman, Edo O Aarts, Ignace M C Janssen, Martin Gotthardt, Baudewijn W Hendrickx, Frits J Berends
BACKGROUND: After Roux-en-Y gastric bypass (RYGB), approximately 10% of patients have insufficient weight loss (excess body mass index loss<50%). Gastric pouch emptying may have a role in weight loss. OBJECTIVES: To compare pouch emptying of patients with poor weight loss and patients with successful weight loss after RYGB. SETTING: A research-intensive nonacademic hospital and center of expertise in bariatric surgery in the Netherlands METHODS: Female patients were included from among patients with the least (poor weight loss group [P-WL]) and the most weight loss (successful weight loss group [S-WL]) in our center 2 years after RYGB...
August 12, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28935200/benefit-risk-of-intraoperative-liver-biopsy-during-bariatric-surgery-review-and-perspectives
#6
REVIEW
Sandrine Barbois, Catherine Arvieux, Vincent Leroy, Fabian Reche, Nathalie Stürm, Anne-Laure Borel
Nonalcoholic fatty liver disease (NAFLD) is a metabolic complication of obesity that encompasses a spectrum of conditions, including hepatic steatosis, nonalcoholic steatohepatitis (NASH), cirrhosis, and end-stage liver disease. Screening for NAFLD is important to limit progression, allow early detection of carcinoma, and follow the need for liver transplantation. Although noninvasive markers exist, hepatic histologic evaluation remains the gold standard for diagnosis. To reduce the risk of complications after liver biopsy but increase the accuracy of NAFLD diagnosis, hepatic tissue can be sampled during bariatric surgery...
August 14, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28935199/systematic-review-and-retrospective-validation-of-prediction-models-for-weight-loss-after-bariatric-surgery
#7
REVIEW
Alistair J Sharples, Kamal Mahawar, Chandra V N Cheruvu
BACKGROUND: Patients often have less than realistic expectations of the weight loss they are likely to achieve after bariatric surgery. It would be useful to have a well-validated prediction tool that could give patients a realistic estimate of their expected weight loss. OBJECTIVES: To perform a systematic review of the literature to identify existing prediction models and attempt to validate these models. SETTING: University hospital, United Kingdom...
August 12, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28933067/central-modulation-of-energy-homeostasis-and-cognitive-performance-after-bariatric-surgery
#8
Hans Eickhoff
In moderately or morbidly obese patients, bariatric surgery has been proven to be an effective therapeutic approach to control body weight and comorbidities. Surgery-mediated modulation of brain function via modified postoperative secretion of gut peptides and vagal nerve stimulation was identified as an underlying mechanism in weight loss and improvement of weight-related diseases. Increased basal and postprandial plasma levels of gastrointestinal hormones like glucagon-like peptide 1 and peptide YY that act on specific areas of the hypothalamus to reduce food intake, either directly or mediated by the vagus nerve, are observed after surgery while suppression of meal-induced ghrelin release is increased...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28931435/circulating-retinol-binding-protein-4-levels-in-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#9
REVIEW
Zhongwei Zhou, Hongmei Chen, Huixiang Ju, Mingzhong Sun
BACKGROUND: Retinol binding protein 4 (RBP4) is implicated in obesity, insulin resistance and type 2 diabetes mellitus that are closely associated with nonalcoholic fatty liver disease (NAFLD). However, recent investigations regarding circulating RBP4 levels in NAFLD are conflicting. This meta-analysis is to determine whether NAFLD, non-alcoholic steatohepatitis (NASH) and simple steatosis (SS) patients have altered RBP4 levels. METHODS: We performed a systematic search in PubMed, EMBASE and The Cochrane Library up until 18 March 2017, and 12 studies comprising a total of 4247 participants (2271 NAFLD patients and 1976 controls) were included in the meta-analysis...
September 20, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28931052/improvement-of-dyspnea-after-bariatric-surgery-is-associated-with-increased-expiratory-reserve-volume-a-prospective-follow-up-study-of-45-patients
#10
Louis Boissière, Jeanne-Marie Perotin-Collard, Eric Bertin, Isabelle Gaubil, Ana Diaz Cives, Coralie Barbe, Sandra Dury, Julie Nardi, François Lebargy, Gaëtan Deslée, Claire Launois
OBJECTIVES: To assess the effects of bariatric surgery in patients with obesity on dyspnea and to analyze the relationships between improvement of dyspnea after bariatric surgery and changes in pulmonary function, especially Expiratory Reserve Volume (ERV) which is the lung volume abnormality most frequently associated with obesity. METHODS: Forty-five patients (5 males/40 females, mean Body Mass Index = 46.2 ± 6.8 kg/m2) were evaluated before and 6 to 12 months after bariatric surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28930514/weight-and-metabolic-outcomes-12-years-after-gastric-bypass
#11
Ted D Adams, Lance E Davidson, Sheldon E Litwin, Jaewhan Kim, Ronette L Kolotkin, M Nazeem Nanjee, Jonathan M Gutierrez, Sara J Frogley, Anna R Ibele, Eliot A Brinton, Paul N Hopkins, Rodrick McKinlay, Steven C Simper, Steven C Hunt
BACKGROUND: Few long-term or controlled studies of bariatric surgery have been conducted to date. We report the 12-year follow-up results of an observational, prospective study of Roux-en-Y gastric bypass that was conducted in the United States. METHODS: A total of 1156 patients with severe obesity comprised three groups: 418 patients who sought and underwent Roux-en-Y gastric bypass (surgery group), 417 patients who sought but did not undergo surgery (primarily for insurance reasons) (nonsurgery group 1), and 321 patients who did not seek surgery (nonsurgery group 2)...
September 21, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28930104/liver-transplantation-in-the-obese-cirrhotic-patient
#12
Erin K Spengler, Jacqueline G O'Leary, Helen S Te, Shari Rogal, Anjana A Pillai, Abdullah Al-Osaimi, Archita Desai, James N Fleming, Daniel Ganger, Anil Seetharam, Georgios Tsoulfas, Martin Montenovo, Jennifer C Lai
Despite the rapidly increasing prevalence of obesity in the transplant population, the optimal management of obese liver transplant candidates remains undefined. Setting strict body mass index cutoffs for transplant candidacy remains controversial, with limited data to guide this practice. Body mass index is an imperfect measure of surgical risk in this population, partly due to volume overload and variable visceral adiposity. Weight loss before transplantation may be beneficial, but it remains important to avoid protein calorie malnutrition and sarcopenia...
October 2017: Transplantation
https://www.readbyqxmd.com/read/28929218/percutaneous-gastric-remnant-gastrostomy-following-roux-en-y-gastric-bypass-surgery-a-single-tertiary-center-s-13-year-experience
#13
Shehbaz Hasam Shaikh, Justin Jay Stenz, David W McVinnie, James J Morrison, Todd Getzen, Arthur M Carlin, Farhaan R Mir
PURPOSE: The purpose of the study is to evaluate the indications, techniques, and outcomes for percutaneous gastrostomy placement in the gastric remnant following Roux-en-Y gastric bypass (RYGB) in bariatric patients. MATERIALS AND METHODS: Retrospective chart review and summary statistical analysis was performed on all RYGB patients that underwent attempted percutaneous remnant gastrostomy placement at our institution between April 2003 and November 2016. RESULTS: A total of 38 patients post-RYGB who underwent gastric remnant gastrostomy placement were identified, 32 women and 6 men, in which a total of 41 procedures were attempted...
September 19, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28928583/single-minute-of-positive-end-expiratory-pressure-at-the-time-of-induction-effect-on-arterial-blood-gases-and-hemodynamics-in-morbidly-obese-patients-undergoing-laparoscopic-bariatric-surgery
#14
Dipti Saxena, Priyank Singh, Atul Dixit, Bipin Arya, Mohit Bhandari, Sadhana Sanwatsarkar
BACKGROUND: The effect of positive end-expiratory pressure (PEEP) has been studied in detail after induction of general anesthesia especially in obese individuals. However, sparse information can be gathered from the literature regarding its effect when applied at the time of induction and the time of onset of its effect. Thus, this study was planned to assess the effect of PEEP when applied for a single minute in morbidly obese patients. MATERIALS AND METHODS: This was a randomized prospective study comprising seven morbidly obese patients (body mass index ≥40 kg/m(2))...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28928326/a-delayed-acute-complication-of-bariatric-surgery-gastric-remnant-haemorrhagic-ulcer-after-roux-en-y-gastric-bypass
#15
Stefan Patrascu, Carmen Balague Ponz, Sonia Fernandez Ananin, Eduardo M Targarona Soler
Acute gastric remnant bleeding is an exceptionally rare complication when it occurs long after bariatric surgery. We present the case of a patient with a bleeding ulcer of the excluded stomach (i.e., the remnant), occurring 7 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity. A computed tomography scan managed to locate the active bleeding source in the gastric remnant. During emergency laparotomy, a bleeding ulcer of the fundic region of the excluded stomach was identified. Total resection of the remnant was performed, with good post-operative recovery...
September 20, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28927340/risk-factors-of-perioperative-morbimortality-after-laparoscopic-sleeve-gastrectomy-a-club-coelio-multicenter-study
#16
B Tulelli, P Loi, E van Vyve, H Johanet, G Fromont, A Dabrowski, A Piquart, T Delaunay, P Ledaguenel, B Navez, F Maisonnette, M Lepere, T Dugué, V Demoor, B Bokobza, Jp Staudt, P Hauters, P Malvaux, J Closset
OBJECTIVES: Postoperative complications after Laparoscopic sleeve gastrectomy (LSG) can dramatically compromise patient's outcome. The aim of this study is to analyze the per- and postoperative short-term outcomes after LSG and to assess predictive risk factors of complications. METHODS: The study group consisted of 790 patients (610 women and 180 men) who underwent LSG In 2014. All interventions were performed by 18 experienced surgeons members of the Club Coelio...
September 19, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28927258/a-proteomics-based-approach-reveals-differential-regulation-of-visceral-adipose-tissue-proteins-between-metabolically-healthy-and-unhealthy-obese-patients
#17
Assim A Alfadda, Afshan Masood, Mohammed Y Al-Naami, Pierre Chaurand, Hicham Benabdelkamel
Obesity and the metabolic disorders that constitute metabolic syndrome are a primary cause of morbidity and mortality in the world. Nonetheless, the changes in the proteins and the underlying molecular pathways involved in the relevant pathogenesis are poorly understood.In this study a proteomic analysis of the visceral adipose tissue isolated from metabolically healthy and unhealthy obese patients was used to identify presence of altered pathway(s) leading to metabolic dysfunction. Samples were obtained from 18 obese patients undergoing bariatric surgery and were subdivided into two groups based on the presence or absence of comorbidities as defined by the International Diabetes Federation...
September 20, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28925645/vitamin-b12-deficiency-recognition-and-management
#18
Robert C Langan, Andrew J Goodbred
Vitamin B12 deficiency is a common cause of megaloblastic anemia, various neuropsychiatric symptoms, and other clinical manifestations. Screening average-risk adults for vitamin B12 deficiency is not recommended. Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years...
September 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28924597/endoscopic-sleeve-gastroplasty-the-learning-curve
#19
Christine Hill, Mohamad El Zein, Abhishek Agnihotri, Margo Dunlap, Angela Chang, Alison Agrawal, Sindhu Barola, Saowanee Ngamruengphong, Yen-I Chen, Anthony N Kalloo, Mouen A Khashab, Vivek Kumbhari
BACKGROUND AND STUDY AIMS:  Endoscopic sleeve gastroplasty (ESG) is gaining traction as a minimally invasive bariatric treatment. Concern that the learning curve may be slow, even among those proficient in endoscopic suturing, is a barrier to widespread implementation of the procedure. Therefore, we aimed to define the learning curve for ESG in a single endoscopist experienced in endoscopic suturing who participated in a 1-day ESG training program. PATIENTS AND METHODS:  Consecutive patients who underwent ESG between February 2016 and November 2016 were included...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28921422/high-incidence-of-secondary-hyperparathyroidism-in-bariatric-patients-comparing-different-procedures
#20
Jih-Hua Wei, Wei-Jei Lee, Keong Chong, Yi-Chih Lee, Shu-Chun Chen, Po-Hsun Huang, Shing-Jong Lin
BACKGROUND: Bariatric surgery is an effective therapy for morbid obesity but may reduce calcium absorption and significantly decrease the bone mineral density. This study examined the prevalence of secondary hyperparathyroidism (SHPT) in obese subjects during follow-up after different bariatric surgeries. We investigated predictors of SHPT. METHODS: We enrolled 1470 obese subjects undergoing bariatric/metabolic surgery with at least 1-year follow-up, including 322 patients undergoing Roux-en-Y gastric bypass (RYGB), 695 undergoing single anastomosis (mini-) gastric bypass (SAGB), 93 undergoing laparoscopic adjustable gastric banding (LAGB), and 360 undergoing sleeve gastrectomy (SG)...
September 18, 2017: Obesity Surgery
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