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https://www.readbyqxmd.com/read/29169145/early-results-on-canine-fetal-kidney-development-ultrasonographic-evaluation-and-value-in-prediction-of-delivery-time
#1
Elaine Mayumi Ueno Gil, Daniela Aparecida Ayres Garcia, Amália Turner Giannico, Tilde Rodrigues Froes
To date there have been no studies that describe the ultrasonographic evaluation of kidney development in canine fetuses. The aim of this prospective and longitudinal study was to monitor fetal kidney development with ultrasound and use fetal kidney measurements as a complementary biometric index for estimation of gestational age. Ultrasonographic examinations were performed on 15 clinically healthy pregnant bitches every four days from 30(th) day of pregnancy, until visualization of the fetal renal pelvis was no longer possible...
November 16, 2017: Theriogenology
https://www.readbyqxmd.com/read/29169037/a-nephron-model-for-study-of-drug-induced-acute-kidney-injury-and-assessment-of-drug-induced-nephrotoxicity
#2
Yueyang Qu, Fan An, Yong Luo, Yao Lu, Tingjiao Liu, Weijie Zhao, Bingcheng Lin
In this study, we developed a multilayer microfluidic device to simulate nephron, which was formed by "glomerulus", "Bowman's capsule", "proximal tubular lumen" and "peritubular capillary". In this microdevice, artificial renal blood flow was circulating and glomerular filtrate flow was single passing through, mimicking the behavior of a nephron. In this dynamic artificial nephron, we observed typical renal physiology, including the glomerular size-selective barrier, glomerular basement membrane charge-selective barrier, glucose reabsorption and para-aminohippuric acid secretion...
November 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/29168475/chronic-kidney-disease
#3
REVIEW
Paola Romagnani, Giuseppe Remuzzi, Richard Glassock, Adeera Levin, Kitty J Jager, Marcello Tonelli, Ziad Massy, Christoph Wanner, Hans-Joachim Anders
Chronic kidney disease (CKD) is defined by persistent urine abnormalities, structural abnormalities or impaired excretory renal function suggestive of a loss of functional nephrons. The majority of patients with CKD are at risk of accelerated cardiovascular disease and death. For those who progress to end-stage renal disease, the limited accessibility to renal replacement therapy is a problem in many parts of the world. Risk factors for the development and progression of CKD include low nephron number at birth, nephron loss due to increasing age and acute or chronic kidney injuries caused by toxic exposures or diseases (for example, obesity and type 2 diabetes mellitus)...
November 23, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29167792/translation-of-the-5d-itching-scale-from-english-to-malay-and-its-validation-among-patients-with-chronic-kidney-disease-in-malaysia
#4
Inayat Ur Rehman, David Bin-Chia Wu, Siew Mei Pauline Lai, Uma Devi Palanisamy, Soo Kun Lim, Tahir Mehmood Khan
Introduction: Several tools have been developed to assess the severity of pruritus. In Malaysia, no tool has been validated to assess pruritus in patients with chronic kidney disease (CKD). Therefore, the aim of our study was to validate the Malay 5D itching scale (M5D-IS) among patients with CKD in Malaysia. Method: The English version of the 5D-IS was translated into Malay according to International Guidelines. Face and content validity was determined by an expert panel and pilot tested in patients with end-stage renal disease (ESRD)...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29167396/targeting-stub1-tissue-factor-axis-normalizes-hyperthrombotic-uremic-phenotype-without-increasing-bleeding-risk
#5
Moshe Shashar, Mostafa E Belghasem, Shinobu Matsuura, Joshua Walker, Sean Richards, Faisal Alousi, Keshab Rijal, Vijaya B Kolachalama, Mercedes Balcells, Minami Odagi, Kazuo Nagasawa, Joel M Henderson, Amitabh Gautam, Richard Rushmore, Jean Francis, Daniel Kirchhofer, Kumaran Kolandaivelu, David H Sherr, Elazer R Edelman, Katya Ravid, Vipul C Chitalia
Chronic kidney disease (CKD/uremia) remains vexing because it increases the risk of atherothrombosis and is also associated with bleeding complications on standard antithrombotic/antiplatelet therapies. Although the associations of indolic uremic solutes and vascular wall proteins [such as tissue factor (TF) and aryl hydrocarbon receptor (AHR)] are being defined, the specific mechanisms that drive the thrombotic and bleeding risks are not fully understood. We now present an indolic solute-specific animal model, which focuses on solute-protein interactions and shows that indolic solutes mediate the hyperthrombotic phenotype across all CKD stages in an AHR- and TF-dependent manner...
November 22, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29167138/recent-advances-in-management-of-autosomal-dominant-polycystic-kidney-disease
#6
REVIEW
Jacob W Potts, Shaker A Mousa
PURPOSE: Promising developments in the search for effective pharmacotherapies for autosomal-dominant polycystic kidney disease (ADPKD) are reviewed. SUMMARY: The formation and development of cysts characteristic of ADPKD result in inexorable renal and extrarenal manifestations that give rise to more rapid disease progression and more widespread complications than are seen with other forms of chronic kidney disease. To date, no agent has gained Food and Drug Administration marketing approval for use in patients with ADPKD, complicating efforts to meet the medical needs of this population...
December 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29167082/disparities-in-health-literacy-and-healthcare-utilization-among-adolescents-and-young-adults-with-chronic-or-end-stage-kidney-disease
#7
Robyn Levine, Karina Javalkar, Meaghan Nazareth, Richard A Faldowski, Maria Diaz-Gonzalez de Ferris, Sarah Cohen, Jessica Cuttance, Stephen R Hooper, Eniko Rak
PURPOSE: Low health literacy adversely affects health outcomes in adults with chronic kidney disease. The current study examined associations between limited/inadequate health literacy and health services utilization among adolescents and young adults (AYA) with chronic or end-stage kidney disease (CKD or ESKD). DESIGN AND METHODS: This was a retrospective cohort study that enrolled patients from both the pediatric- and adult-focused nephrology clinics of a major university hospital...
October 31, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29166753/interventional-locoregional-treatment-and-metabolic-response-advantages-of-using-pet-ct-in-the-evaluation-of-response-to-treatment
#8
Monica Finessi, Marilena Bellò, Francesca P Giunta, Andrea Veltri, Désirée Deandreis
INTRODUCTION: Interventional oncology locoregional therapies are validated treatment modalities for primary and secondary tumors in liver, lung, kidney and bone. At this time, there is no accordance in the choice of imaging modality to assess treatment response. Morphological imaging and RECIST 1.1 criteria based on size variation are limited by several critical points. On the other hand the role of functional imaging, in particular by [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography (PET), in both staging and response evaluation of locoregional treatments remains unclear because of the heterogeneous nature of available data...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166699/comparison-of-clinical-outcomes-of-coronary-artery-stent-implantation-in-patients-with-end-stage-chronic-kidney-disease-including-hemodialysis-for-three-everolimus-eluting-ees-stent-designs-bioresorbable-polymer-ees-platinum-chromium-ees-and-cobalt-chrome-ees
#9
Takao Sato, Katsuharu Hatada, Syohei Kishi, Koichi Fuse, Satoshi Fujita, Yoshio Ikeda, Minoru Takahashi, Taku Matsubara, Masaaki Okabe, Yoshifusa Aizawa
BACKGROUNDS: New-generation bioresorbable polymer-everolimus eluting stents (BP-EES) are available. This study aimed to compare the clinical outcomes for BP-EES compared to more established stent designs, namely the platinum chromium-EES (PtCr-EES) and cobalt chrome-EES(CoCr-EES) in patients with the end-stage chronic kidney disease (CKD) including hemodialysis (HD). METHODS: One-hundred-forty-one consecutive stents (BP-EES [n = 44], PtCr-EES [n = 45], and CoCr-EES [n = 52]) were implanted in 104 patients with CKD...
November 22, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29166543/transcatheter-or-surgical-aortic-valve-replacement-in-patients-with-advanced-kidney-disease-a-propensity-score-matched-analysis
#10
Rajkumar Doshi, Jay Shah, Vaibhav Patel, Varun Jauhar, Perwaiz Meraj
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an alternative for surgically inoperable patients with severe aortic stenosis. Advanced kidney disease may significantly affect outcomes in patients treated with TAVR and surgical aortic valve replacement (SAVR). HYPOTHESIS: TAVR is associated with better in-hospital outcomes compared with SAVR in patients with advanced kidney disease. METHODS: We identified our sample from the National Inpatient Sample between 2012 and 2014, using International Classification of Diseases, Ninth Revision, Clinical Modification codes...
November 22, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29165958/advanced-practice-nurses-and-end-of-life-care-for-patients-with-progressive-chronic-kidney-disease-and-end-stage-renal-disease
#11
Vicki Montoya
No abstract text is available yet for this article.
May 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165954/the-hiv-organ-policy-equity-act-offering-hope-to-individuals-with-end-stage-renal-disease-and-hiv
#12
Emily Arnold
The HIV Organ Policy Equity Act, or HOPE Act, requires the Secretary of Health and Human Services to develop guidelines for research on the transplantation of kidneys and livers from individuals infected with the human immunodeficiency virus (HIV) into patients with end stage organ failure who are also infected with HIV. Although signed into law in 2013, the guidelines were not finalized until November 2015. Currently, 18 transplant centers that wish to participate in this research have received Institutional Review Board approval...
May 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165952/identifying-and-eliminating-the-barriers-to-patient-education-for-patients-in-the-early-stages-of-chronic-kidney-disease
#13
Sherry Rivera
Patients with chronic kidney disease (CKD) often do not have the knowledge they need to adequately manage their disease and prevent progression. Educating patients with the early stages of CKD is warranted and may assist in delaying progression of disease, improving outcomes, and reducing health expenditures. However, evidence is currently lacking regarding the best methods and approach to educating patients in the early stages of CKD. Multiple patient, provider, and system barriers can interfere with the delivery of patient education in the early stages of CKD...
May 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165620/comparative-effectiveness-of-allopurinol-febuxostat-and-benzbromarone-on-renal-function-in-chronic-kidney-disease-patients-with-hyperuricemia-a-13-year-inception-cohort-study
#14
Hsu-Wen Chou, Hsien-Tsai Chiu, Ching-Wei Tsai, I-Wen Ting, Hung-Chieh Yeh, Han-Chun Huang, Chin-Chi Kuo
Background: Direct comparisons of the effectiveness of allopurinol with that of other urate-lowering agents in chronic kidney disease (CKD) populations, as well as guideline recommendations for clinical practice, are lacking. Methods: We constructed a pharmacoepidemiology cohort study by including patients from Taiwan's long-term integrated CKD care program to compare the effectiveness among allopurinol, febuxostat and benzbromarone in reducing the risk of progression to dialysis...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29165595/con-the-role-of-diet-for-people-with-advanced-stage-5-ckd
#15
Graham Woodrow
Restriction of dietary protein intake has been used in the management of chronic kidney disease (CKD) for many decades, yet remains controversial, with marked variations in its application in clinical practice. There is extensive literature on the subject, with some expert opinion advocating the use of protein restriction based on the balance of the available evidence. The largest randomized trial of low-protein diets is the Modification of Diet in Renal Disease study. Despite multiple secondary analyses, the essential intention-to-treat analysis failed to demonstrate a benefit in the primary outcome of rate of decline of glomerular filtration rate...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29164841/home-blood-pressure-measurement-as-a-systematic-tool-for-clinical-practice-in-ckd-patients-a-real-world-picture
#16
Adamasco Cupisti, Lorenzo Ghiadoni, Claudia Zullo, Michele Marchini, Enrico Varricchio, Alessandro Puntoni, Elisabetta Giglio, Ophelia Meniconi, Maria R Bruno, Maria F Egidi
BACKGROUND: Arterial hypertension is very common in chronic kidney disease (CKD) patients and its prevalence increases with lowering estimated glomerular filtration rate (eGFR). Blood pressure (BP) control is a cornerstone in the treatment of CKD patients but still most treatment decisions are based on office BP measurement (OBPM). The aim of this cross-sectional, retrospective study is to investigate the prevalence of hypertension phenotypes in CKD patients and whether different home (HBPM) or OBPM are associated with a different CKD stage and cardiovascular comorbidities...
November 22, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/29164839/residual-renal-and-cardiovascular-disease-risk-in-conventionally-treated-patients-with-type-2-diabetes-the-potential-of-non-traditional-biomarkers-and-treatments-related-redox-metabolism
#17
Karima Zitouni, Mia Steyn, Kenneth A Earle
Diabetes is a leading cause of chronic kidney disease (CKD) in the developed world. Promoters of the progression of kidney disease include the traditional profile of cardiovascular risk factors. However, the development of CKD and vulnerability to end-stage renal disease (ESRD) is highly variable. Determinants of the susceptibility to ESRD may include non-traditional risk factors such as gene-environment interactions, socio-geographic factors and/or treatment strategies. We review the conflicting clinical relevance of studies implicating pathways related to oxidative stress...
November 21, 2017: Minerva Medica
https://www.readbyqxmd.com/read/29164753/prevalence-of-left-ventricular-systolic-dysfunction-in-pre-dialysis-and-dialysis-patients-with-preserved-left-ventricular-ejection-fraction
#18
Liselotte C R Hensen, Kathleen Goossens, Victoria Delgado, Rachid Abou, Joris I Rotmans, J Wouter Jukema, Jeroen J Bax
AIMS: Patients with chronic kidney disease (CKD) have an excess of cardiovascular morbidity and mortality, with heart failure (HF) being particularly frequent. Reduced left ventricular ejection fraction (LVEF) defines left ventricular (LV) systolic dysfunction and is associated with poor prognosis. However, CKD patients may have HF symptoms with preserved LVEF. In this subgroup of patients, two-dimensional speckle tracking echocardiography can detect LV systolic dysfunction by analysing LV myocardial deformation...
November 21, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29163740/the-application-of-sodium-glucose-cotransporter-2-inhibitors-to-chronic-kidney-disease-stage-4
#19
Ayako Koguchi, Hiroki Adachi, Hidekatsu Yanai
No abstract text is available yet for this article.
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29163492/t-cell-composition-of-the-lymph-node-is-associated-with-the-risk-for-early-rejection-after-renal-transplantation
#20
Burç Dedeoglu, Nicolle H R Litjens, Annelies E de Weerd, Frank Jmf Dor, Mariska Klepper, Derek Reijerkerk, Carla C Baan, Michiel G H Betjes
Background: The T-cell composition within the lymph node (LN) of end-stage renal disease (ESRD) patients differs from the composition within the circulation. Activation of the alloreactive T-cell response within secondary lymphoid organs is important after organ transplantation. However, to date no data are present on LN T-cell subsets and the risk for acute rejection after kidney transplantation. Methods: T cells from LNs of ESRD patients were analyzed for frequency of recent thymic emigrants, relative telomere length, expression of differentiation markers, and were related to the development of early acute rejection (EAR), occurring within 3 months after renal transplantation (RT)...
2017: Frontiers in Immunology
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