keyword
https://read.qxmd.com/read/38456646/melatonin-and-melatonin-receptor-agonists-in-the-treatment-of-nocturia-a-systematic-review
#21
REVIEW
Christine Anh Burke, Victor W Nitti, Lynn Stothers
AIM: Causes of nocturia may extend beyond primary bladder pathology and it has been commonly associated as a side effect of sleep disorders. This has led to the study of melatonin and melatonin receptor agonists as a primary treatment for nocturia hypothesized to be secondary to sleep disorders. We aim to systematically review the efficacy and reported safety of melatonin and melatonin receptor agonists in the treatment of nocturia. METHODS: A search strategy of EMBASE and Pubmed/Medline databases was utilized to identify eligible studies...
March 8, 2024: Neurourology and Urodynamics
https://read.qxmd.com/read/38454824/clinical-outcome-and-safety-of-holmium-laser-prostate-enucleation-after-transrectal-prostate-biopsies-for-benign-prostatic-hyperplasia
#22
JOURNAL ARTICLE
See Min Choi, Chang Seok Kang, Dae Hyun Kim, Jae Hwi Choi, Chunwoo Lee, Seong Uk Jeh, Sung Chul Kam, Jeong Seok Hwa, Jae Seog Hyun
PURPOSE: This study aimed to assess the clinical outcome and safety of holmium laser enucleation of the prostate (HoLEP) following transrectal ultrasound-guided prostate biopsy (TR biopsy) in the treatment of benign prostate hyperplasia. MATERIALS AND METHODS: We retrospectively analyzed data from 556 patients who underwent HoLEP between 2014 and 2021. The patients were categorized into six groups: Group 1-A (n=45) underwent HoLEP within four months post TR biopsy...
March 2024: Investigative and Clinical Urology
https://read.qxmd.com/read/38452757/a-2-week-treatment-with-5-azacytidine-improved-the-hypercontractility-state-in-prostate-from-obese-mice-role-of-the-nitric-oxide-cyclic-guanosine-monophosphate-signalling-pathway
#23
JOURNAL ARTICLE
Ana Carolina Ghezzi, Gabriela Reolon Passos, Mariana Gonçalves de Oliveira, Akila Lara Oliveira, Guilherme Rossi Assis-Mendonça, Glaucia Coelho de Mello, Edson Antunes, Fabiola Zakia Monica
Benign prostatic hyperplasia (BPH) is characterised by increases in prostate volume and contraction. Downregulation of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signalling pathway contributes to prostate dysfunctions. Previous studies in cancer cells or vessels have shown that the epigenetic mechanisms control the gene and protein expression of the enzymes involved in the production of NO and cGMP. This study is aimed to evaluate the effect of a 2-week treatment of 5-azacytidine (5-AZA), a DNA-methyltransferase inhibitor, in the prostate function of mice fed with a high-fat diet...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38451253/the-efficacy-and-safety-of-prostatic-urethral-lift-as-a-minimally-invasive-therapeutic-modality-to-treat-lower-urinary-tract-symptoms-while-maintaining-sexual-function-in-patients-with-benign-prostatic-hyperplasia-a-systematic-review-and-meta-analysis-of-randomized
#24
JOURNAL ARTICLE
Syah Mirsya Warli, Muhammad Fahmi Ikram, Raja Gerald Sarumpaet, Zaimah Zulkarnaini Tala, Ignatius Ivan Putrantyo
BACKGROUND: Benign Prostatic Hyperplasia (BPH) is prevalent among elderly men, necessitating focused attention. The Prostatic Urethral Lift (PUL) procedure, a minimally invasive intervention, has emerged as a promising option for BPH management. It has shown remarkable results in ameliorating Lower Urinary Tract Symptoms (LUTS), enhancing quality of life, and preserving sexual function. This study aims to evaluate the effectiveness and safety of PUL in BPH patients. METHODS: Key databases (MEDLINE, Cochrane CENTRAL, ScienceDirect, EBSCO, Google Scholar) were systematically searched using pertinent terms related to PUL and BPH...
March 7, 2024: Archivio Italiano di Urologia, Andrologia
https://read.qxmd.com/read/38451129/a-prospective-randomized-study-comparing-the-outcome-after-thulium-laser-enucleation-of-the-prostate-with-conventional-monopolar-turp-for-the-treatment-of-symptomatic-benign-prostatic-hyperplasia
#25
JOURNAL ARTICLE
Ajaykumar Dhirubhai Tadha, Debansu Sarkar, Dilip Kumar Pal
OBJECTIVE: This is a prospective randomized study with the aim of comparing (thulium laser enucleation of the prostate (ThuLEP) and transurethral resection of the prostate (TURP) for benign prostatic hyperplasia (BPH) treatment. METHODS: Patients are assessed preoperatively and up to 6 months postoperatively. International Prostate Symptom Score (IPSS), quality of life (QoL), maximum urinary flow rates (Qmax), international index of erectile function-5 (IIEF-5) and post-void residual volume (PVR) are collected on each follow-up...
January 2024: Urol Res Pract
https://read.qxmd.com/read/38448685/medical-advancements-in-benign-prostatic-hyperplasia-treatments
#26
REVIEW
Vishnuvardhan Ganesan, Deepak Agarwal
PURPOSE OF REVIEW: This review aims to identify and summarize the current literature on the most recent therapeutic agents and combination strategies for the medical management of lower urinary tract symptoms resulting from benign prostatic hyperplasia. RECENT FINDINGS: The latest advancements in BPH therapy have been in combination strategies. Alpha blockers continue to be the mainstay of treatment, but research is exploring the synergistic benefits of combining them with 5-alpha reductase inhibitors (5-ARIs), phosphodiesterase-5 (PDE5) inhibitors, and beta-3 agonists...
March 7, 2024: Current Urology Reports
https://read.qxmd.com/read/38441094/benign-prostatic-hyperplasia-time-to-upgrade-treatment-guidelines-regarding-prostatic-artery-embolization
#27
EDITORIAL
M Mahesh
No abstract text is available yet for this article.
March 2024: Radiology
https://read.qxmd.com/read/38440742/prostatic-artery-embolization-via-inferior-epigastric-collateral-in-chronic-total-occlusion-of-the-anterior-division-of-the-left-internal-iliac-artery
#28
Le Nguyen Vu, Le Thanh Dung, Than Van Sy, Le Quy Thien, Ngo Quang Duy, Pham Huu Khuyen
Prostatic artery embolization (PAE) is one of the new treatment therapies for lower urinary tract symptoms in male patients with benign prostatic hyperplasia. PAE is considered a minimally invasive option besides other famous traditional therapies such as transurethral resection of the prostate (TURP) and open surgery. Additionally, PAE has a specific advantage in managing the elderly group and underlying health conditions like anticoagulation. In this article, we presented the case of an 83-year-old male patient who has chronic urinary retention due to benign prostatic hyperplasia, left coronary artery stent placement, and long-term anticoagulation...
May 2024: Radiology Case Reports
https://read.qxmd.com/read/38439581/tirna-gly-gcc-001-in-major-depressive-disorder-promising-diagnostic-and-therapeutic-biomarker
#29
JOURNAL ARTICLE
Haihua Tian, Shugui Gao, Miaomiao Xu, Mei Yang, Mengyuan Shen, Jimeng Liu, Guangxue Li, Dingding Zhuang, Zhenyu Hu, Chuang Wang
BACKGROUND AND PURPOSE: In major depressive disorder (MDD), exploration of biomarkers will be helpful in diagnosing the disorder as well as in choosing a treatment and predicting the treatment response. Currently, tRNA-derived small ribonucleic acids (tsRNAs) have been established as promising non-invasive biomarker candidates that may enable a more reliable diagnosis or monitoring of various diseases. Herein, we aimed to explore tsRNA expression together with functional activities in MDD development...
March 4, 2024: British Journal of Pharmacology
https://read.qxmd.com/read/38438956/radiogenomic-analysis-of-ultrasound-phenotypic-features-coupled-to-proteomes-predicts-metastatic-risk-in-primary-prostate-cancer
#30
JOURNAL ARTICLE
Qihuan Fu, Li Luo, Ruixia Hong, Hang Zhou, Xinzhi Xu, Yujie Feng, Kaifeng Huang, Yujie Wan, Ying Li, Jiaqi Gong, Xingyan Le, Xiu Liu, Na Wang, Jiangbei Yuan, Fang Li
BACKGROUND: Primary prostate cancer with metastasis has a poor prognosis, so assessing its risk of metastasis is essential. METHODS: This study combined comprehensive ultrasound features with tissue proteomic analysis to obtain biomarkers and practical diagnostic image features that signify prostate cancer metastasis. RESULTS: In this study, 17 ultrasound image features of benign prostatic hyperplasia (BPH), primary prostate cancer without metastasis (PPCWOM), and primary prostate cancer with metastasis (PPCWM) were comprehensively analyzed and combined with the corresponding tissue proteome data to perform weighted gene co-expression network analysis (WGCNA), which resulted in two modules highly correlated with the ultrasound phenotype...
March 4, 2024: BMC Cancer
https://read.qxmd.com/read/38431818/d-hormone-and-its-significance-for-function-of-prostate-gland-literature-review-and-personal-observations
#31
JOURNAL ARTICLE
Nataliia M Brechka, Volodymyr O Bondarenko, Olena V Shcherbak, Yeugenia M Korenieva
OBJECTIVE: Aim: The aim of this article is to present literature data and personal research of the role of D-hormoneon the functioning of the male reproductive system, and more specifically of the prostate gland, as well as the use of this vitamin D during the complex and independent treatment of benign prostatic hyperplasia in preclinical studies and clinical practice. PATIENTS AND METHODS: Materials and Methods: The collection of relevant data were done using the scientific databases Pubmed, Google Scholar...
2024: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38429006/medical-management-of-benign-prostatic-hyperplasia
#32
REVIEW
Eiftu S Haile, Ayodeji E Sotimehin, Bradley C Gill
Medical management of benign prostatic hyperplasia (BPH) has progressed gradually in recent years and remains the starting point for most symptomatic patients seeking treatment. Beyond well-known alpha-blockers and 5-alpha reductase inhibitors, there is growing evidence for the use of phosphodiesterase-5 inhibitors and beta-3 agonists in managing the condition, which may afford additional relief of "bothersome" symptoms in some patients. This review details contemporary medical management of BPH with an emphasis on the indications for certain classes of pharmacotherapy and their relative benefits and side effects...
March 1, 2024: Cleveland Clinic Journal of Medicine
https://read.qxmd.com/read/38427070/a-rare-ewing-like-small-round-cell-tumor-in-prostate-a-case-report-and-literature-review
#33
REVIEW
Zhen Wang, Jian Ye, Junjie Hu, Nan Zhang, Yichu Yuan
BACKGROUND: Small round cell tumor (SRCT) is a group of malignancy with similar optical microscopic morphology. Despite its low incidence, SRCT has a high malignant degree and poor prognosis. Besides, atypical clinical symptoms make it difficult in preoperative diagnosis. CASE REPORT: A 67-year-old man was presented to the outpatient service with dysuria and weak urine stream lasting for 3 months. After oral treatment with tamsulosin and finasteride for 2 months, the symptoms worsen...
March 1, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38421483/alpha-blockers-the-magic-pill-for-endourology-the-great-delusion
#34
REVIEW
Peter Kronenberg
PURPOSE: The present paper takes a different and more critical look at the role of alpha-blockers, sometimes nicknamed as "magical pills", in particular for stone disease and medical expulsive therapy (MET). METHODS: A non-systematic narrative review was performed, synthesizing pertinent information from selected articles, and critically evaluating their conclusions. Sometimes different views on alpha-blockers were laid bare, including curiosities or other entertaining nuances suitable to the present topic, but always maintaining sharp objectivity and the foremost scientific rigor...
February 29, 2024: World Journal of Urology
https://read.qxmd.com/read/38421373/early-investigational-agents-for-the-treatment-of-benign-prostatic-hyperplasia
#35
REVIEW
Stamatios Katsimperis, Konstantinos Kapriniotis, Ioannis Manolitsis, Themistoklis Bellos, Panagiotis Angelopoulos, Patrick Juliebø-Jones, Bhaskar Somani, Andreas Skolarikos, Lazaros Tzelves
INTRODUCTION: Benign prostatic hyperplasia (BPH), as a clinical entity that affects many people, has always been in the forefront of interest among researchers, pharmaceutical companies, and physicians. Patients with BPH exhibit a diverse range of symptoms, while current treatment options can occasionally cause adverse events. All the aforementioned have led to an increased demand for more effective treatment options. AREAS COVERED: This review summarizes the outcomes of new medications used in a pre-clinical and clinical setting for the management of male lower urinary tract symptoms (LUTS)/BPH and provides information about ongoing trials and future directions in the management of this condition...
February 29, 2024: Expert Opinion on Investigational Drugs
https://read.qxmd.com/read/38420752/transperineal-microwave-thermoablation-for-benign-prostatic-hyperplasia-related-lower-urinary-tract-symptoms-in-an-elderly-patient
#36
JOURNAL ARTICLE
Yaşar Türk, İsmail Devecioğlu, Nusret Can Çilesiz, Barış Nuhoğlu
Transperineal prostate microwave thermoablation (TPMT) has been established as a safe means of treating benign prostatic hyperplasia (BPH); however, its effectiveness in addressing BPH-related lower urinary tract symptoms (LUTS) remains unexplored. This case study aims to evaluate the efficacy of TPMT in LUTS attributed to BPH. An 84-year-old man with LUTS due to BPH-induced bladder outlet obstruction, unresponsive to previous medical treatments, and failed prostate artery embolization, underwent TPMT. Three coaxial needles were positioned at the midline, right, and left sides of the hypertrophic transitional zone of the prostate...
February 29, 2024: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://read.qxmd.com/read/38420594/yap-mediated-gper-signaling-impedes-proliferation-and-survival-of-prostate-epithelium-in-benign-prostatic-hyperplasia
#37
JOURNAL ARTICLE
Zhifu Liu, Senmao Li, Shengbin Chen, Jindong Sheng, Zheng Li, Tianjing Lv, Wei Yu, Yu Fan, Jinlong Wang, Wei Liu, Shuai Hu, Jie Jin
Benign prostatic hyperplasia (BPH) occurs when there is an imbalance between the proliferation and death of prostate cells, which is regulated tightly by estrogen signaling. However, the role of G protein-coupled estrogen receptor (GPER) in prostate cell survival remains ambiguous. In this study, we observed that prostates with epithelial hyperplasia showed increased yes-associated protein 1 (YAP) expression and decreased levels of estrogen and GPER. Blocking YAP through genetic or drug interventions led to reduced proliferation and increased apoptosis in the prostate epithelial cells...
March 15, 2024: IScience
https://read.qxmd.com/read/38412066/recent-advances-in-nanotechnology-based-drug-delivery-systems-for-the-diagnosis-and-treatment-of-reproductive-disorders
#38
REVIEW
Biswajeet Acharya, Amulyaratna Behera, Suchismeeta Behera, Srikanta Moharana
Over the past decade, nanotechnology has seen extensive integration into biomedical applications, playing a crucial role in biodetection, drug delivery, and diagnostic imaging. This is especially important in reproductive health care, which has become an emerging and significant area of research. Global concerns have intensified around disorders such as infertility, endometriosis, ectopic pregnancy, erectile dysfunction, benign prostate hyperplasia, sexually transmitted infections, and reproductive cancers...
February 27, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38411727/natural-products-in-the-treatment-of-lower-urinary-tract-dysfunction-and-infection
#39
JOURNAL ARTICLE
Ann-Kathrin Lederer, Martin C Michel
The popularity of natural products for the treatment of lower urinary tract symptoms (LUTS) differs considerably between countries. Here we discuss the clinical evidence for efficacy in two indications, male LUTS suggestive of benign prostatic hyperplasia and urinary tract infections, and the mechanistic evidence from experimental studies. Most evidence for male LUTS is based on extracts from saw palmetto berries, stinging nettle roots, and pumpkin seeds, whereas most evidence for urinary tract infection is available for European golden rod and combined preparations although this field appears more fragmented with regard to extract sources...
February 28, 2024: Handbook of Experimental Pharmacology
https://read.qxmd.com/read/38408537/pla-inhibits-tnf-%C3%AE-induced-panoptosis-of-prostate-cancer-cells-through-metabolic-reprogramming
#40
JOURNAL ARTICLE
Yinghui Hao, Fangmei Xie, Jieyi He, Chenqiong Gu, Ying Zhao, Wenfeng Luo, Xiaoyu Song, Jian Shen, Li Yu, Zeping Han, Jinhua He
Previous studies have shown that phenyllactic acid (alpha-Hydroxyhydrocinnamic acid, 2-Hydroxy-3-phenylpropionic acid, PLA), a type of organic acid metabolite, has excellent diagnostic efficacy when used to differentiate between prostate cancer, benign prostatic hyperplasia, and prostatitis. This research aims to explore the molecular mechanism by which PLA influences the PANoptosis of prostate cancer (PCa) cell lines. First, we found that PLA was detected in all prostate cancer cell lines (PC-3, PC-3M, DU145, LNCAP)...
February 24, 2024: International Journal of Biochemistry & Cell Biology
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