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https://www.readbyqxmd.com/read/28817870/re-quality-of-life-in-patients-with-lower-urinary-tract-symptoms-associated-with-bph-change-over-time-in-real-life-practice-according-to-treatment-the-qualiprost-study
#1
https://www.readbyqxmd.com/read/28813783/comprehensive-overview-of-prostatitis
#2
REVIEW
Farhan Ullah Khan, Awais Ullah Ihsan, Hidayat Ullah Khan, Ruby Jana, Junaid Wazir, Puregmaa Khongorzul, Muhammad Waqar, Xiaohui Zhou
Prostatitis is a common urinary tract syndrome that many doctors find problematic to treat effectively. It is the third most commonly found urinary tract disease in men after prostate cancer and Benign Prostate Hyperplasia (BPH). Prostatitis may account for 25% of all office visits made to the urological clinics complaining about the genital and urinary systems all over the world. In the present study, we classified prostatitis and comprehensively elaborated the etiology, pathogenesis, diagnosis, and treatment of acute bacterial prostatitis (category I), chronic bacterial prostatitis (category II), chronic pelvic pain syndrome (CPPS) (category III), and asymptomatic prostatitis (category IV)...
August 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28811943/reviewing-the-emergence-of-lactococcus-garvieae-a-case-of-catheter-associated-urinary-tract-infection-caused-by-lactococcus-garvieae-and-escherichia-coli-coinfection
#3
Tatvam T Choksi, Farhan Dadani
Lactococcus garvieae is considered a low virulence organism which is rarely associated with human infections. Most of the reported cases have been associated with bacteremia with or without endocarditis. We report a rare case of catheter associated urinary tract infection (CAUTI) caused by Lactococcus garvieae and Escherichia coli coinfection without any bacteremia in a patient with indwelling urinary catheter placed for benign prostatic hyperplasia (BPH). The patient also had a history of gastroesophageal reflux disease (GERD) with long standing famotidine treatment...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28808847/evaluation-of-hyoscine-n-butyl-bromide-efficacy-on-the-prevention-of-catheter-related-bladder-discomfort-after-transurethral-resection-of-prostate-a-randomized-double-blind-control-trial
#4
Golnar Sabetian, Farid Zand, Elham Asadpour, Mohammad Ghorbani, Pourya Adibi, Mohammad Mehdi Hosseini, Shahryar Zeyghami, Farzaneh Masihi
BACKGROUND: Transurethral resection of prostate (TURP) is the most common treatment for benign prostatic hyperplasia (BPH). Urinary tract catheter is inserted post-operatively which results in catheter-related bladder discomfort (CRBD) in many patients. The purpose of this study was to assess the preventive effect of hyoscine N-butyl bromide on CRBD caused by a urinary tract catheter after TURP surgery in patients with BPH. METHODS: Twenty-four and twenty-six patients in the treatment and control groups were enrolled, respectively...
August 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28795417/molecular-pathogenesis-of-human-prostate-basal-cell-hyperplasia
#5
Gervaise Henry, Alicia Malewska, Ryan Mauck, Jeffrey Gahan, Ryan Hutchinson, Jose Torrealba, Franto Francis, Claus Roehrborn, Douglas Strand
BACKGROUND: Understanding the molecular pathogenesis of distinct phenotypes in human benign prostatic hyperplasia (BPH) is essential to improving therapeutic intervention. Current therapies target smooth muscle and luminal epithelia for relief of lower urinary tract symptoms (LUTS) due to BPH, but basal cell hyperplasia (BCH) remains untargeted. The incidence of has been reported at 8-10%, but a molecular and cellular characterization has not been performed on this phenotype. METHODS: Using freshly digested tissue from surgical specimens, we performed RNA-seq analysis of flow cytometry-purified basal epithelia from 3 patients with and 4 patients without a majority BCH phenotype...
August 10, 2017: Prostate
https://www.readbyqxmd.com/read/28795212/a-review-of-adverse-events-related-to-prostatic-artery-embolization-for-treatment-of-bladder-outlet-obstruction-due-to-bph
#6
Airton Mota Moreira, André Moreira de Assis, Francisco Cesar Carnevale, Alberto Azoubel Antunes, Miguel Srougi, Giovanni Guido Cerri
INTRODUCTION: Minimally invasive procedures have gained great importance among the treatments for benign prostate hyperplasia (BPH) due to their low morbidity. Prostate artery embolization has emerged as a safe and effective alternative for patients with large volume BPH, not suited for surgery. MATERIALS AND METHODS: Low adverse events rates have been reported following prostate artery embolization and may include dysuria, urinary infection, hematuria, hematospermia, acute urinary retention and rectal bleeding...
August 9, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28791232/optimising-patient-outcomes-with-photoselective-vaporization-of-the-prostate-pvp-a-review
#7
REVIEW
Claire Pascoe, Darren Ow, Marlon Perera, Henry H Woo, Greg Jack, Nathan Lawrentschuk
Benign prostatic hyperplasia (BPH) is a common pathology causing lower urinary tract symptoms (LUTS) and may significantly impact quality of life. While transurethral resection of the prostate (TURP) remains the gold standard treatment, there are many evolving technologies that are gaining popularity. Photoselective vaporization of the prostate (PVP) is one such therapy which has been shown to be non-inferior to TURP. We aimed to review the literature and discuss factors to optimise patient outcomes in the setting of PVP for BPH...
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28791231/medium-term-efficacy-of-the-prostatic-urethral-lift
#8
REVIEW
Peter Chin, Peter Robertson
Treatment options for patients with benign prostatic hyperplasia have traditionally revolved around pharmacotherapy or invasive surgery, both of which can negatively impact quality of life (QoL). The quest for a suitable minimally invasive surgical therapy as an alternative to long-term medication or conventional surgery, has seen the development of heat-based therapies, most of which have been dismissed because of post-operative complications and unacceptable re-treatment rates. During the late 1980s and 1990s, mechanical approaches such as transurethral balloon dilation and prostatic urethral stenting were investigated; however, re-treatment rates, encrustation and unacceptable migration rate of stents saw these options fall into disuse...
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28782621/yongdamsagan-tang-a-traditional-herbal-formula-inhibits-cell-growth-through-the-suppression-of-proliferation-and-inflammation-in-benign-prostatic-hyperplasia-epithelial-1-cells
#9
Eunsook Park, Mee-Young Lee, Chang-Seob Seo, Woo-Young Jeon, Hyeun-Kyoo Shin
ETHNOPHARMACOLOGICAL RELEVANCE: Benign prostatic hyperplasia (BPH), also called benign enlargement of the prostate, is a progressive disease that is observed in most elderly men. Yongdamsagan-tang, a traditional herbal formula, is used commonly for the treatment of inflammation-related diseases. Although the therapeutic efficacy of Yongdamsagan-tang against BPH in vivo was reported previously, its underlying mechanisms are not clearly understood. AIM OF THE STUDY: In this study, we investigated the effect of Yongdamsagan-tang water extract (YSTE) and its mechanism on the growth of human BPH epithelial BPH-1 cells...
August 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28780635/convective-radiofrequency-water-vapor-thermal-therapy-with-rez%C3%A5-m-system
#10
REVIEW
Sevann Helo, Bradley Holland, Kevin T McVary
PURPOSE: Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are amongst the most commonly treated conditions by urologists. Minimally invasive therapies for the treatment of BPH/LUTS have garnered increased interest as new technology has emerged, improving durability, efficacy, and safety. This paper reviews the most recent literature regarding water vapor therapy, a convective thermal therapy that ablates prostatic tissue. RECENT FINDINGS: The current literature includes a pilot study of 65 men and a randomized controlled trial (RCT) of 197 men investigating the efficacy and safety profile of water vapor therapy up to 2 years...
October 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28780626/prospective-controlled-assessment-of-men-s-sexual-function-changes-following-holmium-laser-enucleation-of-the-prostate-for-treatment-of-benign-prostate-hyperplasia
#11
Ahmed M Elshal, Ahmed El-Assmy, Ramy Mekkawy, Diaa-Eldin Taha, Ahmed R El-Nahas, Mahmoud Laymon, Hamdy El-Kappany, El-Housseiny Ibrahiem
OBJECTIVES: To assess how much Holmium laser enucleation of the prostate (HoLEP) is detrimental on men sexuality. METHODS: Between January and December 2013, all patients presented for BPH surgery were assessed using IIEF-15 (international index of erectile function-15) and Ej-MSHQ (ejaculatory domain-male sexual health questionnaire). Changes in men's sexuality following HoLEP in relation to control procedure were prospectively assessed. Intervention group included legible consecutive patients treated by HoLEP...
August 5, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28776548/correlation-between-cholinergic-innervation-autophagy-and-etiopathology-of-benign-prostatic-hyperplasia
#12
Jian-Liang Cai, Wei-Min Yao, Yan-Qun Na
BACKGROUND: Whether cholinergic innervations and/or autophagy have a role in the etiopathology of benign prostatic hyperplasia (BPH) is still unknown. This study aimed to investigate the role of cholinergic innervation and autophagy in the etiopathology of BPH. METHODS: Male, 13-week-old spontaneous hypertension rats (spontaneous BPH animal model) were divided into three groups: an experimental group (EG, n = 24), a control group (CG, n = 24), and a normal control group (NC, n = 10)...
August 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28765672/analysis-of-thermally-denatured-depth-in-laser-vaporization-for-benign-prostatic-hyperplasia-using-a-simulation-of-light-propagation-and-heat-transfer-secondary-publication
#13
Junya Takada, Norihiro Honda, Hisanao Hazama, Naomasa Ioritani, Kunio Awazu
Background and Aims: Laser vaporization of the prostate is expected as a less invasive treatment for benign prostatic hyperplasia (BPH), via the photothermal effect. In order to develop safer and more effective laser vaporization of the prostate, it is essential to set optimal irradiation parameters based on quantitative evaluation of temperature distribution and thermally denatured depth in prostate tissue. Method: A simulation model was therefore devised with light propagation and heat transfer calculation, and the vaporized and thermally denatured depths were estimated by the simulation model...
December 30, 2016: Laser Therapy
https://www.readbyqxmd.com/read/28760246/efficacy-and-safety-of-a-fixed-dose-combination-therapy-of-tamsulosin-and-tadalafil-for-patients-with-lower-urinary-tract-symptoms-and-erectile-dysfunction-results-of-a-randomized-double-blinded-active-controlled-trial
#14
Sae Woong Kim, Nam Cheol Park, Seung Wook Lee, Dae Yul Yang, Jong Kwan Park, Du Geon Moon, Sang-Kuk Yang, Sung Won Lee, Ki Hak Moon, Tai Young Ahn, Soo Woong Kim, Kwangsung Park, Kweon Sik Min, Ji-Kan Ryu, Hankil Son, Jina Jung, Jae Seog Hyun
BACKGROUND: Phosphodiesterase type 5 inhibitors and α-adrenergic blocking agents (α-blockers) are widely used for the treatment of erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). AIMS: To assess the efficacy and safety of fixed-dose combinations (FDCs) of tamsulosin and tadalafil compared with tadalafil monotherapy in patients with comorbid BPH-associated LUTS and ED. METHODS: A randomized, double-blinded, active-controlled trial was conducted of 510 men with BPH-associated LUTS and ED...
August 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28757757/current-consensus-and-controversy-on-the-diagnosis-of-male-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia
#15
REVIEW
Cheng-Ling Lee, Hann-Chorng Kuo
Traditionally, male lower urinary tract symptoms (LUTS) have been considered a synonym for benign prostate hyperplasia (BPH) because most male LUTS develops in aging men. Medical treatment should be the first-line treatment for BPH and surgical intervention should be performed when there are complications or LUTS refractory to medical treatment. Recent investigations have revealed that bladder dysfunction and bladder outlet dysfunction contribute equally to male LUTS. In the diagnosis of LUTS suggestive of BPH (LUTS/BPH), the following questions should be considered: Is there an obstruction? Are the LUTS caused by an enlarged prostate? What are the appropriate tools to diagnose an obstructive BPH? Should patients with LUTS be treated before bladder outlet obstruction is confirmed? This article discusses the current consensus and controversies in the diagnosis of LUTS/BPH...
January 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28757756/current-consensus-and-controversy-on-the-treatment-of-male-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia
#16
REVIEW
Chun-Hou Liao, Hann-Chorng Kuo
Lower urinary tract symptoms (LUTS) are highly prevalent in men and increase with age. Because LUTS are common among elderly men, they are usually considered synonymous with benign prostatic hyperplasia (BPH). Drugs should be the first-line treatment for BPH and surgical intervention should be performed only when there are complications or LUTS refractory to medical treatment. In addition to medical treatment, several minimally invasive therapies, such as thermal therapy, prostatic lift, laser evaporation, or laser enucleation techniques have been developed...
January 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28753866/diagnostic-and-prognostic-microrna-biomarkers-for-prostate-cancer-in-cell-free-urine
#17
Jacob Fredsøe, Anne K I Rasmussen, Anni R Thomsen, Peter Mouritzen, Søren Høyer, Michael Borre, Torben F Ørntoft, Karina D Sørensen
BACKGROUND: Widespread use of prostate-specific antigen (PSA) testing for prostate cancer (PC) detection has led to extensive overdiagnosis and overtreatment. Urine-based microRNA (miRNA) biomarkers could be useful in PC diagnosis and prognosis. OBJECTIVE: To train and validate urine-based microRNA (miRNA) biomarkers that may assist in PC diagnosis and prognosis. DESIGN, SETTING, AND PARTICIPANTS: We profiled the expression levels of 92 miRNAs via reverse transcriptase-poymerase chain reaction in cell-free urine samples from 29 patients with benign prostatic hyperplasia (BPH) and 215 patients with clinically localized PC (cohort 1)...
March 9, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28735516/dnmt1-regulates-il-6-and-tgf-%C3%AE-1-induced-epithelial-mesenchymal-transition-in-prostate-epithelial-cells
#18
Hui Xu, Yanbo Chen, Qi Chen, Huan Xu, Yanxia Wang, Jiao Yu, Juan Zhou, Zhong Wang, Bing Xu
Multiple factors have been considered to play a role in the development of benign prostatic hyperplasia (BPH), including chronic inflammation, hormones, and epithelial-mesenchymal transition (EMT). Inflammation is regarded as one of the potential inducers of EMT. However, the mechanisms, modulating pro-inflammatory factors (IL-6 and TGF-β1) induce EMT features, have not yet been studied in BPH. In this study, we investigated whether DNA methyltransferases1 (DNMT1) could regulate IL-6 and TGF-β1 induce EMT...
May 3, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28727906/potential-of-telmisartan-in-the-treatment-of-benign-prostatic-hyperplasia
#19
Ismail Ogunbayode Ishola, Charles C Anunobi, Kehinde Habeeb Tijani, Olasunmbo Afolayan, Victoria U Udokwu
Benign prostatic hyperplasia (BPH) is a common health problem in aging men. This study was carried out to investigate the protective effect of telmisartan on testosterone induced-BPH in rats. Fifty-four male Wistar rats (200 - 250g) were randomly divided into 9 groups (n =6) and orally treated for 28 consecutive days: group 1- vehicle normal, olive oil (10 ml/kg); group 2- BPH model control (10 ml/kg); groups 3-5 - telmisartan (5, 10 or 20 mg/kg, respectively); group 6- pioglitazone (20 mg/kg); group 7- celecoxib (20 mg/kg); group 8- combination of telmisartan (5 mg/kg) and pioglitazone (20 mg/kg); group 9- combination of telmisartan (5 mg/kg) and celecoxib (20 mg/kg)...
July 20, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28725598/canine-prostate-models-in-preclinical-studies-of-minimally-invasive-interventions-part-ii-benign-prostatic-hyperplasia-models
#20
REVIEW
Fei Sun, Claudia Báez-Díaz, Francisco Miguel Sánchez-Margallo
Canine prostate is widely used as animal model in the preclinical evaluation of emerging therapeutic interventions. Spontaneous benign prostatic hyperplasia (BPH) is common in adult intact male dogs with two distinct pathological types: glandular and complex form of prostatic hyperplasia. The complex form of prostatic hyperplasia, usually occurring in older dogs, represents an ideal model because of its unique pathologic feature, including not only glandular hyperplasia but also an increase in prostate stromal components...
June 2017: Translational Andrology and Urology
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