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https://www.readbyqxmd.com/read/29775639/surgical-management-of-lower-urinary-tract-symptoms-attributed-to-benign-prostatic-hyperplasia-aua-guideline
#1
Harris E Foster, Michael J Barry, Philipp Dahm, Manhar C Gandhi, Steven A Kaplan, Tobias S Kohler, Lori B Lerner, Deborah J Lightner, J Kellogg Parsons, Claus G Roehrborn, Charles Welliver, Timothy J Wilt, Kevin T McVary
Purpose; Male lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) is common in men and can have negative effects on quality of life (QOL). It is the hope that this Guideline becomes a reference on the effective evidence-based surgical management of LUTS/BPH. MATERIALS/METHODS: The evidence team searched Ovid MEDLINE, the Cochrane Library, and the Agency for Healthcare Research and Quality (AHRQ) database to identify studies indexed between January 2007 and September 2017...
May 15, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29774816/holmium-laser-enucleation-of-the-prostate
#2
Marcelino E Rivera, James E Lingeman, Amy E Krambeck
INTRODUCTION: Holmium laser enucleation of the prostate (HoLEP) offers superior voiding outcomes to traditional transurethral resection and less morbidity than open simple prostatectomy. Likewise, HoLEP has been determined to result in excellent outcomes regardless of gland size. We present a step-by-step surgical approach to HoLEP describing both the traditional enucleation technique and a modified "top-down" surgical technique. MATERIALS AND METHODS: In this video, two techniques are presented that were performed by two (A...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29770312/state-of-the-art-of-prostatic-arterial-embolization-for-benign-prostatic-hyperplasia
#3
REVIEW
Mario Petrillo, Filippo Pesapane, Enrico Maria Fumarola, Ilaria Emili, Marzia Acquasanta, Francesca Patella, Salvatore Alessio Angileri, Umberto G Rossi, Igor Piacentini, Antonio Maria Granata, Anna Maria Ierardi, Gianpaolo Carrafiello
Prostatectomy via open surgery or transurethral resection of the prostate (TURP) is the standard treatment for benign prostatic hyperplasia (BPH). Several patients present contraindication for standard approach, individuals older than 60 years with urinary tract infection, strictures, post-operative pain, incontinence or urinary retention, sexual dysfunction, and blood loss are not good candidates for surgery. Prostatic artery embolization (PAE) is emerging as a viable method for patients unsuitable for surgery...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29738187/-influence-of-photoselective-vaporization-of-the-prostate-on-the-sexual-function-of-the-patient
#4
REVIEW
Hua-Jie Zhang, Guo-Sheng Yang
n recent years, photoselective vaporization of the prostate (PVP) has gained a wide clinical application in the treatment of benign prostatic hyperplasia (BPH) for its satisfactory effect, high safety, and low incidence of complications. With the improvement of living conditions, BPH patients are paying more attention to their sexual function, especially erectile function and ejaculatory problems instead of just focusing on the alleviation of lower urinary tract symptoms. Few studies of PVP, however, relate to its association with the sexual function of the patient and there is a certain controversy over the influence of PVP on it in the existing literature...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29738178/-thulium-laser-vaporization-versus-transurethral-resection-of-the-prostate-and-risk-factors-for-postoperative-urethral-stricture
#5
Wen Song, Tao Wang, Qing Ling, Xia-Ming Liu, Zhong Chen, Xiao-Dong Song, Xiao-Lin Guo, Qian-Yuan Zhuang, Shao-Gang Wang, Ji-Hong Liu
Objective: To compare thulium laser vaporization of the prostate (TLVP) and transurethral resection of the prostate (TURP) in the treatment of benign prostate hyperplasia (BPH) analyze the risk factors for postoperative urethral stricture. METHODS: From June 2015 to June 2016, 210 BPH patients in our hospital underwent TURP (n = 126) or TLVP (n = 84). We followed up the patients for 6 months, compared the effects of the two surgical strategies and analyzed the risk factors for postoperative urethral stricture by multivariate logistic regression analysis...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29737501/safety-of-tamsulosin-a-systematic-review-of-randomized-trials-with-a-focus-on-women-and-children
#6
REVIEW
Steven A Kaplan, Bilal I Chughtai
INTRODUCTION: Although tamsulosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH), it has also been assessed in clinical studies for other conditions/symptoms and in other populations such as women and children. In this systematic review of randomized studies, the overall safety of tamsulosin was assessed, focusing on these understudied populations. METHODS: Literature searches were conducted using Embase, Medline, and PubMed (inception-December 2015)...
May 8, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29737092/-study-of-kinase-inhibitor-wp1066-on-the-stat3-jak2-of-prostate-stromal-cells
#7
Yun-Xiang Li, Jin-Ming Li, Qiang Wei, Zong-Ping Zhang, Ji Wu, An-Guo Wang
OBJECTIVE: To study the role of JAK2 signaling pathway in prostate stromal cells and the effect of inhibitor WP1066 on its expression. METHODS: The phosphorylation of JAK2 and STAT3 in prostate tissues of patients with benign prostatic hyperplasia (BHP) ( n =4) and severe histological prostatitis (HP) plus BPH ( n =4) was tested by using Western blot to verify the activation of their mediated signaling pathway. Kinase inhibitor WP1066 was added to prostate stromal cells to detect inhibition of the JAK2 and STAT3 activation launched by IL-6...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29732214/ten-years-of-intraoperative-floppy-iris-syndrome-in-the-era-of-%C3%AE-blockers
#8
REVIEW
Andreas Lunacek, Badereddin Mohamad Al-Ali, Christian Radmayr, Maria Weber, Wolfgang Horninger, Oliver Findl, Eugen Plas
Introduction: The use of alpha-1 receptor antagonists in the treatment of benign prostatic hyperplasia (BPH) has created a problem in ophthalmic surgery, the so-called intraoperative floppy iris syndrome (IFIS). This consists of a billowing iris, insufficient pupillary dilation with progressive intraoperative miosis, and protrusion of iris tissue through the tunnel and side port incision that are made for access to the anterior chamber during surgery. IFIS presents particular difficulties in cataract surgery which is carried out through the pupil with manipulations in the immediate vicinity of the iris...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29727542/-3-1-bladder-function-restoration-combined-with-holmium-laser-enucleation-of-the-prostate-for-benign-prostatic-hyperplasia-with-acontractile-detrusor
#9
Xiang Wan, Chong Liu, Huan Xu, Meng Gu, Yan-Bo Chen, Yu-Bing Peng, Qi Chen, Zhi-Kang Cai, Zhong Wang
Objective: To investigate the clinical effect of "3+1" bladder function restoration combined with holmium laser enucleation of the prostate (HoLEP) in the treatment of benign prostatic hyperplasia (BPH) with acontractile detrusor (ACD). METHODS: We treated 35 BPH patients with ACD by HoLEP followed by "3+1" bladder function restoration, that is, a 3-phase bladder function training plus simultaneous 1-drug medication after surgery. We recorded and analyzed the detrusor pressure, post-void residual urine volume (PVR), maximum urinary flow rate (Qmax), International Prognostic Scoring System (IPSS) scores, quality of life (QoL), voluntary micturition, satisfaction with the bladder function, hydronephrosis, ureterectasia, renal function, and urinary tract infection of the patients before and after treatment...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29705832/green-light-photoselective-vaporization-of-the-prostate-a-safe-and-effective-treatment-for-elderly-high-risk-benign-prostate-hyperplasia-patients-with-gland-over-80-ml
#10
Jie Sun, An Shi, Zhen Tong, Chenfei Chi
To analyze the efficacy of Green Light photoselective vaporization of the prostate (PVP) in elderly high-risk benign prostatic hyperplasia (BPH) patients with glands over 80 ml. From December 2013 to February 2016, we allocated 84 elderly (age 71-97) high-risk patients who underwent preoperative transrectal ultrasound (TRUS) examination with glands over 80 ml and divided them into two groups to receive 120 W (n = 40) and 180 W (n = 44) PVP. All the patients have been observed at least one intraoperative comorbidity: hypertension, diabetes mellitus, NYHA II, or combined...
April 28, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29703729/nice-recommends-prostate-artery-embolisation-as-a-treatment-option-for-bph-symptoms
#11
Susan Mayor
No abstract text is available yet for this article.
April 27, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29700686/follow-up-of-temporary-implantable-nitinol-device-tind-implantation-for-the-treatment-of-bph-a-systematic-review
#12
REVIEW
Riccardo Bertolo, Cristian Fiori, Daniele Amparore, Francesco Porpiglia
PURPOSE OF REVIEW: The purpose of the present systematic review is to offer a narrative synthesis of the available literature regarding the role of the temporary implantable nitinol device (TIND) (Medi-Tate®; Medi-Tate Ltd., Or Akiva, Israel) for the treatment of benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS), specifically focusing on the follow-up data. RECENT FINDINGS: Current available evidences are limited in this topic. Sample size of patients available for analysis is small...
April 26, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29697376/efficacy-of-silodosin-urorec%C3%A2-in-the-treatment-of-benign-prostatic-hyperplasia-the-maximum-decrease-of-bladder-outlet-obstruction-index
#13
A Khamzin, R Frolov
One of the main causes of lower urinary tract symptoms in men over the age of 40 years old is benign prostatic hyperplasia (BPH), which according to the research is detected in 26.2% of men of this age group. The purpose of this study was to evaluate the efficacy of the use of silodosin (Urorec®) at dosage 8 mg once a day for relief of obstructive symptoms of BPH in men over 40 years old. From September 2016 till December 2017 144 men (residents of Almaty, the Republic of Kazakhstan) aged from 56 to 81 years old (63...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29695083/the-commonly-used-bactericide-bismerthiazol-promotes-rice-defenses-against-herbivores
#14
Pengyong Zhou, Xiaochang Mo, Wanwan Wang, Xia Chen, Yonggen Lou
Chemical elicitors that enhance plant resistance to pathogens have been extensively studied, however, chemical elicitors that induce plant defenses against insect pests have received little attention. Here, we found that the exogenous application of a commonly used bactericide, bismerthiazol, on rice induced the biosynthesis of constitutive and/or elicited jasmonic acid (JA), jasmonoyl-isoleucine conjugate (JA-Ile), ethylene and H₂O₂ but not salicylic acid. These activated signaling pathways altered the volatile profile of rice plants...
April 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29694707/efficacy-and-safety-of-a-hexanic-extract-of-serenoa-repens-permixon-%C3%A2-for-the-treatment-of-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia-luts-bph-systematic-review-and-meta-analysis-of-randomized-controlled-trials-and-observational
#15
Remigio Vela-Navarrete, Antonio Alcaraz, Alfredo Rodríguez-Antolín, Bernardino Miñana López, Jesús M Fernández-Gómez, Javier C Angulo, David Castro Díaz, Javier Romero-Otero, Francisco J Brenes, Joaquín Carballido, José M Molero García, Antonio Fernández-Pro Ledesma, José Manuel Cózar Olmos, José Manasanch Dalmau, Isaac Subirana Cachinero, Michael Herdman, Vincenzo Ficarra
OBJECTIVES: To comprehensively evaluate the efficacy and safety of the hexanic extract of Serenoa repens (HESr, Permixon), at a dose of 320 mg daily, as monotherapy for the treatment of LUTS/BPH. MATERIALS AND METHODS: Systematic review and meta-analysis of randomized and observational studies in patients with LUTS/BPH identified through searches in Medline, Web of Knowledge [ISI], Scopus, the Cochrane Library, and bibliographic references up to March 2017. Articles studying S...
April 25, 2018: BJU International
https://www.readbyqxmd.com/read/29694702/aquablation-procedural-outcomes-for-bph-in-large-prostates-80-150cc-initial-experience
#16
Mihir Desai, Mo Bidair, Naeem Bhojani, Andrew Trainer, Andrew Arther, Eugene Kramolowsky, Leo Doumanian, Dean Elterman, Ronald P Kaufman, James Lingeman, Amy Krambeck, Gregg Eure, Gopal Badlani, Mark Plante, Edward Uchio, Greg Gin, Larry Goldenberg, Ryan Paterson, Alan So, Mitch Humphreys, Claus Roehrborn, Steven Kaplan, Jay Motola, Kevin C Zorn
BACKGROUND AND AIMS: To present early safety and feasibility data from a multicenter prospective study of Aquablation in treatment of symptomatic men with large volume BPH. METHODS: Between September and December 2017, 101 men with moderate-to-severe BPH symptoms and prostate volume of 80-150cc underwent Aquablation in a prospective multicenter international clinical trial. Baseline demographics and standardized postoperative management parameters were carefully recorded in a central independently monitored database...
April 25, 2018: BJU International
https://www.readbyqxmd.com/read/29690562/ethanol-extract-of-evodia-rutaecarpa-attenuates-cell-growth-through-caspase-dependent-apoptosis-in-benign-prostatic-hyperplasia-1-cells
#17
Eunsook Park, Mee-Young Lee, Chang-Seob Seo, Ji-Hye Jang, Yong-Ung Kim, Hyeun-Kyoo Shin
The dried fruits of Evodia rutaecarpa Bentham have been used widely as a herbal medicine for the treatment of inflammatory disorders and abdominal pain. Benign prostatic hyperplasia (BPH) is a nonmalignant disease characterized by overgrowth of prostates. Despite the pharmacological efficacy of the fruits of E. rutaecarpa against various diseases, their effects against BPH have not been reported. Here, we investigated the inhibitory activity of a 70% ethanol extract of E. rutaecarpa (EEER) against BPH, and its underlying mechanisms regarding cell growth of BPH using BPH-1 cells...
April 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29682196/testosterone-metabolites-inhibit-proliferation-of-castration-and-therapy-resistant-prostate-cancer
#18
Felix Bremmer, Hubertus Jarry, Valerie Unterkircher, Silke Kaulfuss, Peter Burfeind, Heinz-Joachim Radzun, Philipp Ströbel, Paul Thelen
Novel treatments for castration-resistant prostate cancer (CRPC) such as abiraterone acetate (AA) or enzalutamide effectively target the androgen pathway to arrest aberrant signalling and cell proliferation. Testosterone is able to inhibit tumour cell growth in CRPC. Estrogen receptor-beta (ERβ) binds the testosterone-metabolites 3β-androstanediol and 3α-androstanediol in parallel to the canonical estradiol. In the prostate it is widely accepted that ERβ regulates estrogen signalling, mediating anti-proliferative effects...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29680951/urologists-attitudes-to-sexual-complications-of-luts-bph-treatments
#19
Simone Giona, Indranil Ganguly, Gordon Muir
INTRODUCTION: Many LUTS/BPH treatments currently available may affect sexual function (SD). We wished to assess urologists' attitude and practice in this area. METHODS: Attendees of an international meeting were randomly selected, interviewed and stratified by professional status and LUTS/BPH cases seen per month. There were four questions: treatment options offered, frequency of discussing erectile dysfunction (ED) with each treatment, frequency of discussing ejaculatory dysfunction (EjD) with each treatment, and offering alternative treatment based on the risks of sexual dysfunction...
April 21, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29679999/emerging-newly-approved-treatments-for-lower-urinary-tract-symptoms-secondary-to-benign-prostatic-hypertrophy
#20
Hannah Pham, Pranav Sharma
INTRODUCTION: Oral therapy with alpha-blockers or 5-alpha reductase inhibitors remains the most common treatment in men with lower urinary tract symptoms (LUTS) secondary to benign prostatic hypertrophy (BPH). For patients who progress or fail medical therapy, the standard of care surgical treatment continues to be transurethral resection of the prostate (TURP), which has long-studied and durable outcomes. Emerging, minimally invasive options for LUTS secondary to the BPH, however, have been developed over the last decade with promising results and minimal side effects typically associated with TURP, such as retrograde ejaculation and erectile dysfunction...
April 2018: Canadian Journal of Urology
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