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https://www.readbyqxmd.com/read/28229211/multicenter-international-experience-of-532%C3%A2-nm-laser-photo-vaporization-with-greenlight-xps-in-men-with-large-prostates-prostate-volume%C3%A2-%C3%A2-100%C3%A2-cc
#1
Malek Meskawi, Pierre-Alain Hueber, Roger Valdivieso, Franck Bruyere, Vincent Misrai, Georges Fournier, Ravi Munver, Ganesh Sivarajan, Matthew Rutman, Alexis E Te, Bilal Chughtai, Dean Elterman, Tristan Martel, Mounsif Azizi, Pierre I Karakiewicz, Kevin C Zorn
PURPOSE: To evaluate the outcomes and durability of photoselective vaporization of the prostate (PVP) using the XPS-180 system in patients with a large prostate volume (PV) > 100 cc at 4 years of follow-up in a large, multicenter experience. METHODS: 438 men with pre-operative transrectal ultrasound (TRUS) PV > 100 cc were treated in eight experienced centers in Canada, USA, and in France with the Greenlight XPS laser using PVP for the treatment of symptomatic BPH...
February 22, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28228662/risk-of-gynecomastia-and-breast-cancer-associated-with-the-use-of-5-alpha-reductase-inhibitors-for-benign-prostatic-hyperplasia
#2
Katrina Wilcox Hagberg, Hozefa A Divan, Shona C Fang, J Curtis Nickel, Susan S Jick
BACKGROUND: Clinical trial results suggest that 5-alpha reductase inhibitors (5ARIs) for the treatment of benign prostatic hyperplasia (BPH) may increase the risk of gynecomastia and male breast cancer, but epidemiological studies have been limited. PATIENTS AND METHODS: We conducted a cohort study with nested case-control analyses using the UK Clinical Practice Research Datalink. We identified men diagnosed with BPH who were free from Klinefelter syndrome, prostate, genital or urinary cancer, prostatectomy or orchiectomy, or evidence of gynecomastia or breast cancer...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28216927/intraprostatic-ozone-therapy-a-minimally-invasive-approach-in-benign-prostatic-hyperplasia
#3
Shabbir Hussain, Deepti B Sharma, Fanindra S Solanki, Ajay Pathak, Dhananjay Sharma
INTRODUCTION: Transurethral resection of prostate (TURP) remains the golden standard therapy since decades. There are various minimally invasive therapies (MITs) for the treatment of benign prostatic hyperplasia (BPH). Still, there is a need for therapy with lesser side effects and better outcome. We had studied the effect of intraprostatic ozone injection (IPOI) as an MIT for patients with BPH who have failed trial without catheter (TWOC). MATERIALS AND METHODS: Thirty elderly patients with BPH with a prostate size of 30 g or more were enrolled for the study...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28216900/trichosanthes-kirilowii-exerts-androgenic-activity-via-regulation-of-psa-and-klk2-in-22rv1-prostate-cancer-cells
#4
Soo-Jin Jeong, Ji-Yoon Choi, Mi-Sook Dong, Chang-Seob Seo, Hyeun-Kyoo Shin
BACKGROUND: The androgen comprises a group of hormones that play roles in male reproductive activity as well as personal characteristics. OBJECTIVE: We investigated the androgenic activity of various herbal medicines in human prostate cancer 22Rv1 cells. MATERIALS AND METHODS: Herbal extracts of Trichosanthes kirilowii (TK), Asarum sieboldii (AS), Sanguisorba officinalis (SO), and Xanthium strumarium (XS) were selected to have androgenic effects based on a preliminary in vitro screening system...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28214356/comparative-analysis-of-the-transcriptional-responses-to-low-and-high-temperature-in-three-rice-planthopper-species
#5
Hai-Jian Huang, Jian Xue, Ji-Chong Zhuo, Ruo-Lin Cheng, Hai-Jun Xu, Chuan-Xi Zhang
The brown planthopper (Nilaparvata lugens, BPH), white-backed planthopper (Sogatella furcifera, WBPH), and small brown planthopper (Laodelphax striatellus, SBPH) are important rice pests in Asia. These three species differ in thermal tolerance and exhibit quite different migration and overwintering strategies. To understand the underlying mechanisms, we sequenced and compared the transcriptome of the three species under different temperature treatments. We found that metabolism-, exoskeleton-, and chemosensory-related genes were modulated...
February 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28211173/methyl-jasmonate-ameliorates-testosterone-propionate-induced-prostatic-hyperplasia-in-castrated-wistar-rats
#6
Olubukola Oyebimpe Akanni, Olusoji John Abiola, Oluwatosin Adekunle Adaramoye
Benign prostate hyperplasia (BPH) is a progressive disease that is related to age. Known therapeutic agents used in the treatment of BPH are associated with toxicity. Therefore, chemoprevention could be an effective approach. We investigated the ameliorative effects of methyl jasmonate (MeJA) in testosterone propionate (TP)-induced BPH in castrated rats. Castration was performed by removing both testes through the scrotum sack under ketamine anesthesia. Rats were assigned into seven groups of seven animals each: non-castrated control, castrated control, castrated rats that received TP, castrated rats that received TP and MeJA, castrated rats that received TP and finasteride, castrated rats that received MeJA, and castrated rats that received finasteride...
February 16, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28210019/the-correlation-between-prostate-volume-in-patients-with-benign-prostatic-hyperplasia-in-relation-to-erectile-dysfunction
#7
Amel Kardasevic, Snjezana Milicevic
INTRODUCTION: The exact etiology of lower urinary tract symptoms caused by benign prostatic hyperplasia (BPH) has not yet been determined, and the etiology of erectile dysfunction (ED) is often multicausal and includes organic and/or psychogenic causes, as well as their combinations. Although the relation of BPH, and thus the volume of the prostate (VP) with ED is indisputable, precise mechanisms of integration are still under examination. GOAL: The objective was to evaluate the correlation between prostate volume and degree of erectile dysfunction in patients with symptoms of lower urinary tract caused by benign prostatic hyperplasia...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28196103/anti-proliferative-activities-of-finasteride-in-benign-prostate-epithelial-cells-require-stromal-fibroblasts-and-c-jun-gene
#8
Kai Wang, Song Jin, Dongdong Fan, Mingshuai Wang, Nianzeng Xing, Yinong Niu
This study aimed to identify the role of mouse fibroblast-mediated c-Jun and IGF-1 signaling in the therapeutic effect of finasteride on benign prostatic epithelial cells. BPH-1 cells, alone or with fibroblasts (c-Jun+/+ or c-Jun-/-), were implanted subcutaneously in male nude mice who were then treated with finasteride. The degrees of cell proliferation, apoptosis, and sizes of the xenografts were determined. BPH-1 cells were grown alone or co-cultured with mouse fibroblasts in the presence of finasteride and the level of IGF-1 secreted into the medium by the fibroblasts was determined...
2017: PloS One
https://www.readbyqxmd.com/read/28181685/effects-of-estrogen-receptor-%C3%AE-stimulation-in-a-rat-model-of-non-bacterial-prostatic-inflammation
#9
Shinsuke Mizoguchi, Kenichi Mori, Zhou Wang, Teresa Liu, Yasuhito Funahashi, Fuminori Sato, Donald B DeFranco, Naoki Yoshimura, Hiromitsu Mimata
BACKGROUND: There is increasing evidence showing that chronic non-bacterial prostatic inflammation is involved in the pathogenesis of benign prostatic hyperplasia (BPH) and male lower urinary tract symptoms (LUTS). It has also been reported that estrogen receptor β (ERβ) could have an immunoprotective role in prostatic tissue. Therefore, we investigated the effect of ERβ-activation on not only prostatic inflammation, but also bladder overactive conditions in a rat model with nonbacterial prostatic inflammation...
February 9, 2017: Prostate
https://www.readbyqxmd.com/read/28175975/prostatic-tissue-elimination-after-prostatic-artery-embolization-pae-a-report-of-three-cases
#10
Leandro Cardarelli Leite, Andre Moreira de Assis, Airton Mota Moreira, Sardis Honoria Harward, Alberto Azoubel Antunes, Francisco Cesar Carnevale
PURPOSE: We report three cases of spontaneous prostatic tissue elimination through the urethra while voiding following technically successful prostatic artery embolization (PAE) as a treatment for lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH). METHODS: All patients were embolized with 100- to 300-μm microspheres alone or in combination with 300- to 500-μm microspheres. RESULTS: During follow-up prior to eliminating the tissue fragments, the three patients all presented with intermittent periods of LUTS improvement and aggravation...
February 7, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28149748/extravasation-of-urine-associated-with-bilateral-complete-ureteral-duplication-vesicoureteral-reflux-and-benign-prostatic-hyperplasia
#11
Issei Suzuki, Kanya Kaga, Kohei Takei, Yuumi Tokura, Kazumasa Sakamoto, Daisaku Nishihara, Tomoya Mizuno, Hideo Yuki, Hironori Betsunoh, Hideyuki Abe, Masahiro Yashi, Yoshitatsu Fukabori, Tomonori Yamanishi, Takao Kamai
We report a rare case of extravasation of urine, which may be associated with bilateral complete ureteral duplication, vesicoureteral reflux (VUR), and benign prostatic hyperplasia (BPH). A 71-year-old male presented with a complaint of right abdominal pain. An extravasation of urine was noted, and was improved by indwelling urethral catheterization. Transurethral resection of the prostate and the endoscopic subureteral injection of dextanomer/hyaluronic acid were performed for the treatment of BPH and VUR, respectively...
February 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28145028/effects-of-steroidal-antiandrogen-or-5-alpha-reductase-inhibitor-on-prostate-tissue-hormone-content
#12
Yasuhiro Shibata, Seiji Arai, Yoshiyuki Miyazawa, Takahiro Shuto, Masashi Nomura, Yoshitaka Sekine, Hidekazu Koike, Hiroshi Matsui, Kazuto Ito, Kazuhiro Suzuki
BACKGROUND: The effects of a steroidal antiandrogen (AA) and 5-alpha-reductase inhibitor (5ARI) on prostate tissue hormone content and metabolism are not fully elucidated. The objective of this study is to investigate the hormone content and metabolism of the prostate tissues of patients treated with AA or 5ARI using the ultra-sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. METHODS: Thirty-nine patients with benign prostatic hyperplasia (BPH) undergoing transurethral surgery were included...
February 1, 2017: Prostate
https://www.readbyqxmd.com/read/28130568/prostatic-artery-embolization-as-an-alternative-to-indwelling-bladder-catheterization-to-manage-benign-prostatic-hyperplasia-in-poor-surgical-candidates
#13
Antonio Rampoldi, Fabiane Barbosa, Silvia Secco, Carmelo Migliorisi, Antonio Galfano, Giovanni Prestini, Sardis Honoria Harward, Dario Di Trapani, Pietro Maria Brambillasca, Vercelli Ruggero, Marco Solcia, Francisco Cesar Carnevale, Aldo Massimo Bocciardi
PURPOSE: To prospectively assess discontinuation of indwelling bladder catheterization (IBC) and relief of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) following prostate artery embolization (PAE) in poor surgical candidates. METHODS: Patients ineligible for surgical intervention were offered PAE after at least 1 month of IBC for management of urinary retention secondary to BPH; exclusion criteria for PAE included eligibility for surgery, active bladder cancer or known prostate cancer...
January 27, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28124531/preliminary-assessment-of-neck-circumference-in-benign-prostatic-hyperplasia-in-patients-with-metabolic-syndrome
#14
Yigit Akin, Hakan Gulmez, Erhan Ates, Mehmet Gulum, Murat Savas
OBJECTIVES: To investigate the impact of neck circumference (NC) in the treatment of bening prostatic hyperplasia (BPH) patients with metabolic syndrome (MtS). Additionally, we determined dose response to alpha-blockers and cut-off values for NC and waist circumference (WC), in these patients. MATERIALS AND METHODS: Non-randomized, open-labelled, and multi-centre study was conducted between March 2014 and September 2015. The BPH patients were enrolled and were divided into 2 groups: with MtS (Group 1; n=94) and without MtS (Group 2; n=103)...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28123062/antagonists-of-growth-hormone-releasing-hormone-inhibit-proliferation-induced-by-inflammation-in-prostatic-epithelial-cells
#15
Petra Popovics, Andrew V Schally, Luis Salgueiro, Krisztina Kovacs, Ferenc G Rick
The etiology of benign prostatic hyperplasia (BPH) is multifactorial, and chronic inflammation plays a pivotal role in its pathogenesis. Growth hormone-releasing hormone (GHRH) is a hypothalamic neuropeptide that has been shown to act as paracrine/autocrine factor in various malignancies including prostate cancer. GHRH and its receptors are expressed in experimental models of BPH, in which antagonists of GHRH suppressed the levels of proinflammatory cytokines and altered the expression of genes related to epithelial-to-mesenchymal transition (EMT)...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28111300/aquablation-of-the-prostate-for-symptomatic-benign-prostatic-hyperplasia-one-year-results
#16
Peter Gilling, Paul Anderson, Andrew Tan
PURPOSE: To establish the safety and effectiveness of aquablation, a novel image-guided, robotic-assisted waterjet tissue ablation technology, for the treatment of Benign Prostatic Hyperplasia (BPH). MATERIALS AND METHODS: Prospective single-arm multicentre trial at 3 centres in Australia and New Zealand with 1-year follow-up. Participants were men aged 50-80 years with moderate-to-severe lower urinary tract symptoms as determined by urodynamics. All patients underwent aquablation under image guidance...
January 19, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28098905/cripto-1-promotes-epithelial-mesenchymal-transition-in-prostate-cancer-via-wnt-%C3%AE-catenin-signaling
#17
Yan Liu, Zhenbang Qin, Kuo Yang, Ranlu Liu, Yong Xu
The Cripto-1 (CR-1) derived EGF-CFC family was overexpressed in tumor development enhancing proliferation, epithelial-mesenchymal transition (EMT) and migration of tumor cells. However, correlation between CR-1 and prostate cancer (PCa) remains still unclear. In the present study, we proved that CR-1 was expressed in PCa and its function was in the progression of PCa. Compared with benign prostatic hyperplasia (BPH) tissues, we confirmed that PCa tissues had high expression of CR-1 by immunohistochemistry and statistical data showed that CR-1 promoted properties of EMT in PCa tissues, including the downregulation of the cell adhesion molecules β-catenin (membrane) and E-cadherin while upregulating transcription factors β-catenin...
January 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28092069/treatment-of-concomitant-oab-and-bph
#18
REVIEW
Matthew C Moss, Tameem Rezan, Umar R Karaman, Alex Gomelsky
The etiology of men's lower urinary tract storage and voiding symptoms involves a contribution from both detrusor and outlet. As such, treatment of benign prostatic enlargement (BPE) ± benign prostatic obstruction (BPO) with standard alpha-adrenergic blockade and 5-alpha reductase inhibitor therapy may leave a population of men with persistent and bothersome urinary storage symptoms. An abundance of adequately powered, randomized, placebo-controlled trials indicate that the use of antimuscarinics and beta-3 adrenergic agonists, either alone or in combination with standard BPE/BPO therapy, leads to improvement in storage symptoms...
January 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28078221/testosterone-replacement-therapy-and-voiding-dysfunction
#19
REVIEW
Wesley Baas, Tobias S Köhler
Testosterone replacement therapy (TRT) represents an increasing popular treatment option for men with late-onset hypogonadism (LOH). Because of unsubstantiated beliefs of testosterone's effect on the prostate, the FDA has recently placed a warning on testosterone products, stating that TRT may worsen benign prostatic hyperplasia (BPH). Within this review article we have demonstrated the current understanding of the physiology of testosterone and its relationship with prostatic and lower urinary tract physiology...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28074310/recurrence-of-lower-urinary-tract-symptoms-following-prostate-artery-embolization-for-benign-hyperplasia-single-center-experience-comparing-two-techniques
#20
Francisco Cesar Carnevale, Airton Mota Moreira, Sardis Honoria Harward, Shivank Bhatia, Andre Moreira de Assis, Miguel Srougi, Giovanni Guido Cerri, Alberto Azoubel Antunes
PURPOSE: To compare recurrence of lower urinary tract symptoms (LUTS) recurrence at 12 months following original prostate artery embolization (oPAE) or "proximal embolization first, then embolize distal" (PErFecTED) PAE for benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: 105 consecutive patients older than 45 years, with prostate size greater than 30 cm(3), International Prostate Symptom Score (IPSS) ≥ 8, quality of life (QoL) index ≥ 3, and refractory status or intolerance of medical management were prospectively enrolled between June 2008 and August 2013...
March 2017: Cardiovascular and Interventional Radiology
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