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https://www.readbyqxmd.com/read/28327526/survivin-and-naip-in-human-benign-prostatic-hyperplasia-protective-role-of-the-association-of-serenoa-repens-lycopene-and-selenium-from-the-randomized-clinical-study
#1
Giuseppe Morgia, Antonio Micali, Mariagrazia Rinaldi, Natasha Irrera, Herbert Marini, Domenico Puzzolo, Antonina Pisani, Salvatore Privitera, Giorgio I Russo, Sebastiano Cimino, Antonio Ieni, Vincenzo Trichilo, Domenica Altavilla, Francesco Squadrito, Letteria Minutoli
Benign prostatic hyperplasia (BPH) treatment includes the apoptosis machinery modulation through the direct inhibition of caspase cascade. We previously demonstrated that Serenoa repens (Ser) with lycopene (Ly) and selenium (Se) reawakened apoptosis by reducing survivin and neuronal apoptosis inhibitory protein (NAIP) levels in rats. The aim of this study was to evaluate the effectiveness of Ser-Se-Ly association on survivin and NAIP expression in BPH patients. Ninety patients with lower urinary tract symptoms (LUTS) due to clinical BPH were included in this randomized, double-blind, placebo-controlled trial...
March 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28319477/emerging-techniques-in-truly-minimal-invasive-treatment-options-of-benign-prostatic-obstruction
#2
Karl-Dietrich Sievert, Thomas Kunit
PURPOSE OF REVIEW: Benign prostatic enlargement is a common age-related condition, affecting over 50% of men aged more than 60 years. Side effects of medical therapy and significant morbidity of transurethral resection of the prostate and open surgery led to the development of so-called minimally invasive procedures, with the aim to be efficient but with less morbidity and shorter or no hospitalization. For this review, a systematic literature was performed. We report recent results in different treatment options for benign prostate hypoplasia (BPH) and recommend the best minimal-invasive treatment for BPH...
March 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28317227/trends-in-the-surgical-treatment-of-benign-prostatic-hyperplasia-in-a-tertiary-hospital
#3
Darren Ow, Nathan Papa, Marlon Perera, Peter Liodakis, Shomik Sengupta, Stephen Clarke, Damien M Bolton, Nathan Lawrentschuk
BACKGROUND: To assess current treatment trends and perioperative outcomes of transurethral resection of the prostate (TURP) and photoselective vaporization of the prostate (PVP) in a tertiary institution. METHODS: We prospectively collected a database of all patients undergoing TURP and PVP for benign prostatic hyperplasia (BPH) at a tertiary hospital between January 2011 and December 2013. Patient characteristics such as length of stay, readmission, anticoagulation status, American Society of Anesthesiologists (ASA) score and need for blood transfusion were recorded and analysed...
March 19, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28315497/risk-stratification-for-benign-prostatic-hyperplasia
#4
Fabio Zattoni, Vincenzo Ficarra, Giacomo Novara
Benign prostatic hyperplasia (BPH) represents an important public health problem in ageing men due to frequently associated lower urinary tract symptoms (LUTS), which may impair quality of life. BPH is also a progressive disease, mainly characterized by a worsening of LUTS over time, and in some patients by the occurrence of serious outcomes such as acute urinary retention and need for BPH-related surgery. The management of BPH and LUTS in men should move forward its focus on symptom control only. Indeed, the goals of therapy for BPH are not only to improve bothersome LUTS but also to identify those patients at risk of unfavourable outcomes in order to optimize their management and reduce complications...
March 18, 2017: Urologia
https://www.readbyqxmd.com/read/28314432/-consensus-document-on-the-management-and-follow-up-of-the-male-with-lower-urinary-tract-symptoms-secondary-to-benign-prostate-hyperplasia
#5
F J Brenes Bermúdez, F Brotons Muntó, J Castiñeiras Fernández, J M Cozar Olmo, A Fernández-Pro Ledesma, J A Martín Jiménez, M L Martínez-Berganza Asensio, B Miñana López, J M Molero García
Benign prostate hyperplasia (BPH) is a high-incidence condition. Its diagnosis and treatment is shared between urologists and Primary Care physicians. Its management uses up a significant amount of resources. The Spanish Society of Primary Care Physicians (SEMERGEN), the Spanish Society of General Practitioners and Family Doctors (SEMG), the Spanish Society of Family and Community Medicine (semFYC), and the Spanish Association of Urology (AEU) have prepared a document on the management and monitoring of BPH, in which the aim is to incorporate the latest evidence in order to update the previously published guidelines, and present them here in condensed form...
November 2016: Semergen
https://www.readbyqxmd.com/read/28303843/photoselective-vaporesection-of-the-prostate-with-an-end-firing-lithium-triborate-crystal-laser
#6
Xin Wang, Ming Liu, Yao-Guang Zhang, Sheng-Cai Zhu, Ben Wan, Jian-Ye Wang
BACKGROUND: Photoselective vaporization of the prostate is a technique that is widely used for the treatment of benign prostatic hyperplasia (BPH) and has pronounced advantages compared to the traditional transurethral resection of the prostate. Following the recent introduction of end-firing lithium triborate lasers, we have created a new technique called photoselective vaporesection of the prostate (PVRP). This study described our initial experience using the PVRP technique for the treatment of BPH...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28293871/greenlight-laser-photoselective-vaporization-of-the-prostate-for-treatment-of-benign-prostate-hyperplasia-lower-urinary-tract-symptoms-in-patients-with-different-post-void-residual-urine
#7
Fei Luo, Hong-Hong Sun, Yan-Hui Su, Zhi-Hua Zhang, Ya-Shen Wang, Zhen Zhao, Jian Li
The purpose of this study is to assess the safety and efficacy of GreenLight laser photoselective vaporization of the prostate (PVP) for the treatment of benign prostate hyperplasia/lower urinary tract symptoms (BPH/LUTS) in patients with different post-void residual urine (PVR). BPH/LUTS patients treated with PVP from January 2014 to January 2016 were enrolled in the present study. All patients were divided into PVR > 50, 50 ≤ PVR < 400, and PVR ≥ 400 ml groups, and standard general and urological methods for BPH/LUTS were carried out...
March 14, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28284204/calcium-magnesium-imbalance-implicated-in-benign-prostatic-hyperplasia-and-restoration-by-a-phytotherapeutic-drug-croton-membranaceus-m%C3%A3-ll-arg
#8
George Awuku Asare, Robert A Ngala, Daniel Afriyie, Samuel Adjei, Adriana Nyarko, Yvonne Anang-Quartey, Bernice Asiedu, Derek Doku, Brodrick Y Amoah, Kennedy Bentum, Iddi Musah, Kensese Mossanda
BACKGROUND: Calcium (Ca)- magnesium (Mg) imbalance is implicated in prostate cancer. Ca/Mg ratio increases or decreases with proliferation or apoptosis, respectively. The study examined whether this Ca/Mg imbalance exists in BPH patients and the effect of a phytotherapeutic drug on the Ca/Mg ratio. METHODS: Thirty (30) BPH patients who used the ethanolic root extract of Croton membranaceus (60 mg/day) for 3 months were examined for serum Ca, Mg, phosphate, parathyroid hormone (PTH), vitamin D, prostate specific antigen (PSA) levels and renal function tests (RFT) before (BT) and after treatment (AT) alongside thirty (30) controls...
March 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28275519/sildenafil-citrate-in-combination-with-tamsulosin-versus-tamsulosin-monotherapy-for-management-of-male-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia-a-randomised-double-blind-placebo-controlled-trial
#9
Amr Fawzi, Mostafa Kamel, Emad Salem, Esam Desoky, Mohamed Omran, Hazem Elgalaly, Ahmed Sakr, Aref Maarouf, Salem Khalil
OBJECTIVE: To assess the additive effect of sildenafil citrate to tamsulosin in the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH) in men with or without erectile dysfunction (ED). PATIENTS AND METHODS: In all, 150 men with untreated LUTS/BPH with or without ED were randomised to receive sildenafil 25 mg once daily (OD) or placebo OD (night time) combined with tamsulosin 0.4 mg OD (day time) for 6 months. Changes from pre-treatment scores in International Prostate Symptom Score (IPSS), IPSS-quality of life (QoL) score, maximum urinary flow rate (Qmax), and the five-item version of the International Index of Erectile Function questionnaire (IIEF-5) were assessed at 3 and 6 months...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28270016/urolift-minimally-invasive-surgical-bph-management
#10
REVIEW
Anish Pushkaran, Victoria Stainer, Gordon Muir, Iqbal S Shergill
An ideal treatment option for symptomatic Benign Prostatic Hyperplasia (BPH) should relieve lower urinary tract symptoms (LUTS) and restore Quality of Life (QoL). Currently available medical therapies and surgical options for symptomatic BPH have side effects that adversely affects quality of life. Prostatic urethral lift (PUL) is a novel endourology procedure that promises to relieve LUTS without the aforementioned side effects. Areas covered: We diligently reviewed all the published literature on PUL, till July 2016 using standard search criteria...
March 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28253329/metformin-inhibits-the-proliferation-of-benign-prostatic-epithelial-cells
#11
Zongwei Wang, Xingyuan Xiao, Rongbin Ge, Jijun Li, Cameron W Johnson, Cyrus Rassoulian, Aria F Olumi
OBJECTIVE: Benign prostatic hyperplasia (BPH) is the most common proliferative abnormality of the prostate affecting elderly men throughout the world. Epidemiologic studies have shown that diabetes significantly increases the risk of developing BPH, although whether anti-diabetic medications preventing the development of BPH remains to be defined. We have previously found that stromally expressed insulin-like growth factor 1 (IGF-1) promotes benign prostatic epithelial cell proliferation through paracrine mechanisms...
2017: PloS One
https://www.readbyqxmd.com/read/28248054/-age-related-androgen-deficiency-and-benign-prostatic-hyperplasia-how-to-improve-the-rehabilitation-of-patients-after-transurethral-surgery
#12
A G Martov, D V Ergakov
RELEVANCE: Age-related androgen deficiency often coexists with benign prostatic hyperplasia (BPH), which requires surgical treatment. At the same time, severe lower urinary tract symptoms secondary to BPH are considered a relative contraindication to testosterone replacement therapy. The aim of this study was to evaluate the importance of correcting age-related androgen deficiency in patients with benign prostatic hyperplasia after transurethral operations. MATERIALS AND METHODS: The study comprised 60 patients with androgen deficiency (plasma testosterone levels below12...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28248032/-the-risk-of-bladder-cancer-in-patients-with-prostatic-hyperplasia-and-strategies-to-manage-this-combination
#13
Yu G Alyaev, A M Pshikhachev, A N Perekalina
The combination of bladder cancer with benign prostatic hyperplasia (BPH) occurs in 5-27% of cases. The link between these diseases has not yet been closely investigated. The main role in the pathogenesis of bladder cancer combined with BPH is played by the residual urine and prolonged exposure of urothelium to the urine carcinogens. The choice of surgical treatment modality for the combination of non-muscle invasive bladder cancer and BPH is still a matter of debate. There is no consensus on the safety and appropriateness of simultaneous transurethral resection of the bladder and prostate in these patients...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28248027/-choosing-treatment-for-patients-with-bladder-cancer-combined-with-prostatic-hyperplasia
#14
P V Glybochko, Yu G Alyaev, A M Pshikhachev, N I Sorokin, A M Dymov
AIM: To define treatment selection criteria for patients with bladder cancer combined with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: Between 2006 and 2015, 1148 patients were treated for bladder cancer and 3368 patients for BPH. Among them, 258 (22.5%) patients had both bladder cancer and BPH. 113 (11.6%) patients had indications for surgical treatment of both diseases. In this group, 18 (13.5%) patients also had bladder stones. Only 2 (1.6%) patients had tumor invading the muscle wall, while the remaining patients had non-muscle invasive bladder cancer...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247729/-monopolar-transurethral-enucleation-of-benign-prostatic-hyperplasia-our-initial-experience
#15
D G Tsarichenko, R R Simberdeev, P V Glybochko, Y G Alyaev, L M Rapoport, R B Sukhanov, N I Sorokin, D V Enikeev, D S Davydov
INTRODUCTION: The choice of surgical treatment in patients with BPH is one of the most discussed issues in urology. In recent years, the surgical treatment of prostates of medium and large sizes by means of enucleation has become increasingly popular. OBJECTIVE: The emergence of special loops to perform bipolar and monopolar enucleation using standard equipment for TURP has opened up new possibilities for the treatment of patients with BPH-transurethral monopolar enucleation BPH...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247726/-features-of-diagnosis-and-treatment-of-various-disorders-of-urination-by-physicians-of-the-republic-of-dagestan-and-other-regions-of-the-north-caucasus-and-southern-federal-districts
#16
Z K Gadzhieva, Yu B Kazilov, Yu G Alyaev, I A Aboyan
PURPOSE: This study was aimed to the evaluation of the features of diagnosis and treatment of various urination disorders by physicians of the Republic of Dagestan. MATERIALS AND METHODS: A anonymous questionnaire survey of 32 urologists of the Republic of Dagestan was performed. In addition to urologists, survey was performed among 104 doctors of other specialties, who also treat patients with various urination disorders in their practice: neurologists (9), obstetricians (22), therapists (38), and surgeons (35)...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247660/-the-incidence-of-acute-urinary-retention-as-an-indicator-of-the-quality-of-care-for-patients-with-benign-prostatic-hyperplasia
#17
O I Apolikhin, A V Sivkov, E K Yanenko, M I Katibov, O V Zolotukhin, I A Shaderkin, M Yu Prosyannikov, D A Voitko, A A Tsoi, N A Galiev, Yu V Kastrikin
AIM: To evaluate the incidence of acute urinary retention as an indicator of the quality of care for patients with benign prostatic hyperplasia by the example of "Urology" Program implemented in the Voronezh region. MATERIALS AND METHODS: As part of the program "Urology", the incidence of AUR was used as an indicator of quality of care for patients with BPH. Urological health care for patients with BPH was provided within a three-stage model. For each of the stages standardized packages of detailed methodological materials, including regional standards were developed...
April 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28243790/prospective-randomized-study-comparing-monopolar-with-bipolar-transurethral-resection-of-prostate-in-benign-prostatic-obstruction-36-month-outcomes
#18
Samer Fathi Al-Rawashdah, Antonio Luigi Pastore, Yazan Al Salhi, Andrea Fuschi, Vincenzo Petrozza, Angela Maurizi, Ester Illiano, Elisabetta Costantini, Giovanni Palleschi, Antonio Carbone
OBJECTIVES: Monopolar transurethral resection of the prostate (TURP) is the gold standard surgical treatment for bothersome moderate to severe lower urinary tract symptoms (LUTS) secondary to benign prostate obstruction. The aim of the study is to compare monopolar versus bipolar TURP focusing on operative and functional outcomes, and evaluating complications with a long-term follow-up. METHODS: From January 2007 to July 2014, a total of 497 patients were randomized and prospectively scheduled to undergo bipolar (251) or monopolar (246) TURP...
February 27, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28243746/combination-treatment-with-naftopidil-increases-the-efficacy-of-radiotherapy-in-pc-3-human-prostate-cancer-cells
#19
Yoichi Iwamoto, Kenichiro Ishii, Hideki Kanda, Manabu Kato, Manabu Miki, Shinya Kajiwara, Kiminobu Arima, Taizo Shiraishi, Yoshiki Sugimura
PURPOSE: Clinically, radiotherapy (RT) often leads to the development of prostate cancer (PCa) resistance because of protective responses in cancer cells. One of the mechanisms includes the upregulation of RT-induced antioxidant enzymes. Thus, combination therapy with RT and certain pharmaceutical drugs targeting antioxidant enzymes may be ideal for increasing the efficacy of RT with minimum side effects. Naftopidil is a subtype-selective α1D-adrenoceptor antagonist used for the treatment of benign prostatic hyperplasia (BPH)...
February 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28229211/multicenter-international-experience-of-532%C3%A2-nm-laser-photo-vaporization-with-greenlight-xps-in-men-with-large-prostates-prostate-volume%C3%A2-%C3%A2-100%C3%A2-cc
#20
Malek Meskawi, Pierre-Alain Hueber, Roger Valdivieso, Franck Bruyere, Vincent Misrai, Georges Fournier, Ravi Munver, Ganesh Sivarajan, Matthew Rutman, Alexis E Te, Bilal Chughtai, Dean Elterman, Tristan Martel, Mounsif Azizi, Pierre I Karakiewicz, Kevin C Zorn
PURPOSE: To evaluate the outcomes and durability of photoselective vaporization of the prostate (PVP) using the XPS-180 system in patients with a large prostate volume (PV) > 100 cc at 4 years of follow-up in a large, multicenter experience. METHODS: 438 men with pre-operative transrectal ultrasound (TRUS) PV > 100 cc were treated in eight experienced centers in Canada, USA, and in France with the Greenlight XPS laser using PVP for the treatment of symptomatic BPH...
February 22, 2017: World Journal of Urology
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