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https://www.readbyqxmd.com/read/29643980/perillaldehyde-inhibits-ahr-signaling-and-activates-nrf2-antioxidant-pathway-in-human-keratinocytes
#1
Yoko Fuyuno, Hiroshi Uchi, Mao Yasumatsu, Saori Morino-Koga, Yuka Tanaka, Chikage Mitoma, Masutaka Furue
The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase-1 (HO1) axis in human keratinocytes. Perillaldehyde is the main component of Perilla frutescens , which is a medicinal antioxidant herb traditionally consumed in East Asia...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29629628/neuroprotective-effect-of-polysaccharide-separated-from-perilla-frutescens-britton-var-acuta-kudo-against-h-2-o-2-induced-oxidative-stress-in-ht22-hippocampus-cells
#2
Eui-Baek Byun, Eun-Ji Cho, Yi-Eun Kim, Woo Sik Kim, Eui-Hong Byun
This study was carried out to evaluate the neuroprotective activity of polysaccharide extracts isolated from Perilla frutescens (PEPF) in H2 O2 -treated HT22 hippocampus cells. The PEPF treatment was found to increase the anti-oxidant activities of HT22 hippocampus cells. PEPF treatment resulted in a significant protection of HT22 hippocampus cells against H2 O2 -induced neurotoxicity, this protection ultimately occurred through an inhibition of ROS-mediated intracellular Ca2+ levels leading to MAPKs and NF-κB, as well as the accumulation of PI3K/AKT and Nrf2-mediated HO-1/NQO1 pathways...
April 8, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29629025/protective-effects-of-perilla-oil-and-alpha-linolenic-acid-on-sh-sy5y-neuronal-cell-death-induced-by-hydrogen-peroxide
#3
Ah Young Lee, Ji Myung Choi, Myoung Hee Lee, Jaemin Lee, Sanghyun Lee, Eun Ju Cho
BACKGROUND/OBJECTIVE: Oxidative stress plays a key role in neuronal cell damage, which is associated with neurodegenerative disease. The aim of present study was to investigate the neuroprotective effects of perilla oil (PO) and its active component, alpha-linolenic acid (ALA), against hydrogen peroxide (H2 O2 )-induced oxidative stress in SH-SY5Y neuronal cells. MATERIALS/METHODS: The SH-SY5Y human neuroblastoma cells exposed to 250 µM H2 O2 for 24 h were treated with different concentrations of PO (25, 125, 250 and 500 µg/mL) and its major fatty acid, ALA (1, 2...
April 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29628492/a-43-mhz-low-field-benchtop-1-h-nuclear-magnetic-resonance-method-to-discriminate-perilla-oil-authenticity
#4
Ju Hyun Kim, Hyeon Jeong Lee, Kisung Kwon, Hyang Sook Chun, Sangdoo Ahn, Byung Hee Kim
The aim of this study was to discriminate the authenticity of perilla oils distributed in Korea using their1 H nuclear magnetic resonance (NMR) spectra acquired by a 43 MHz low-field benchtop NMR spectrometer. Significant differences existed in the integration values of all 6 peaks found in the spectrum between authentic and adulterated perilla oil samples. The integration values of 4 peaks that signify the methylene protons present in all fatty acids (FA) and allylic or olefinic protons present in all unsaturated FA were the best variables for establishing perilla oil authenticity...
April 9, 2018: Journal of Oleo Science
https://www.readbyqxmd.com/read/29594776/molecular-dynamics-simulations-of-protein-drug-complexes-a-computational-protocol-for-investigating-the-interactions-of-small-molecule-therapeutics-with-biological-targets-and-biosensors
#5
Jodi A Hadden, Juan R Perilla
MD simulations provide a powerful tool for the investigation of protein-drug complexes. The following chapter uses the aryl acylamidase-acetaminophen system as an example to describe a general protocol for preparing and running simulations of protein-drug complexes, complete with a step-by-step tutorial. The described approach is broadly applicable toward the study of drug interactions in the context of both biological targets and biosensing enzymes.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29562889/transcriptomic-analysis-of-perilla-frutescens-seed-to-insight-into-the-biosynthesis-and-metabolic-of-unsaturated-fatty-acids
#6
BingNan Liao, YouJin Hao, JunXing Lu, HuiYang Bai, Li Guan, Tao Zhang
BACKGROUND: Perilla frutescens is well known for its high α-linolenic acid (ALA) accumulation in seeds and medicinal values as well as a source of edible and general-purpose oils. However, the regulatory mechanisms of the biosynthesis of fatty acid in its seeds remain poorly understood due to the lacking of sequenced genome. For better understanding the regulation of lipid metabolism and further increase its oil content or modify oil composition, time-course transcriptome and lipid composition analyses were performed...
March 21, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29533613/the-intestinal-anti-inflammatory-activity-of-perillaldehyde
#7
Takuya Uemura, Takuya Yashiro, Rei Oda, Naoki Shioya, Tadaaki Nakajima, Masakazu Hachisu, Shoko Kobayashi, Chiharu Nishiyama, Gen-Ichiro Arimura
Monoterpenoid perillaldehyde (PA) is the major component in Perilla frutescens leaf essential oil, but its function in the anti-inflammatory effect is unclear. We explored the anti-inflammatory activity of PA in a dextran sulfate sodium (DSS)-induced colitis mouse model using relief of bodyweight loss (avg. 49.2% recovery; P = 0.094) and colon damage (avg. 35.3% recovery; P < 0.05) by administration of PA at a 100 mg/kg dosage. The PA administration resulted in suppression of DSS-induced expression of pro-inflammatory cytokine genes and matrix metalloproteinase-9 in the colon (e...
March 13, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29482586/assessing-the-efficacy-of-a-culturally-adapted-cognitive-behavioural-internet-delivered-treatment-for-depression-protocol-for-a-randomised-controlled-trial
#8
Alicia Salamanca-Sanabria, Derek Richards, Ladislav Timulak, Leónidas Castro-Camacho, Mónica Mojica-Perilla, Yamilena Parra-Villa
BACKGROUND: Depression is the principal cause of disability in the world. High prevalence rates of depression in general populations and college students have been found worldwide and in various cultural groups. Low-intensity cognitive behavioural internet-delivered treatment has demonstrated efficacy in high-income-countries (HICs). However little is known of their potential for adaptation and efficacy in low and middle-income countries. METHODS: Study (1) involves the cultural adaptation of the Space from Depression cognitive-behaviour internet-delivered programme with an asynchronous support for depressive symptoms...
February 27, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29459511/optimization-of-supercritical-carbon-dioxide-extraction-of-eucommia-ulmoides-seed-oil-and-quality-evaluation-of-the-oil
#9
Zhen-Shan Zhang, Yu-Lan Liu, Li-Ming Che
Supercritical carbon dioxide extraction (SC-CO2 ) technology was used to extract oil from Eucommia ulmoides seed. The optimum conditions and significant parameters in SC-CO2 were obtained using response surface methodology (RSM). The qualities of the extracted oil were evaluated by physicochemical properties, fatty acid composition, vitamin E composition. It was found that the optimum extraction parameters were at pressure of 37 MPa, temperature of 40℃, extraction time of 125 min and CO2 flow rate of 2.6 SL/min...
February 19, 2018: Journal of Oleo Science
https://www.readbyqxmd.com/read/29454864/inactivation-of-escherichia-coli-and-staphylococcus-aureus-on-contaminated-perilla-leaves-by-dielectric-barrier-discharge-dbd-plasma-treatment
#10
Sang Hye Ji, Se Hoon Ki, Ji Ho Ahn, Jae Ho Shin, Eun Jeong Hong, Yun Ji Kim, Eun Ha Choi
This study focused on sterilization methods for the reduction of microorganisms on perilla leaves by cylinder type Dielectric Barrier Discharge (DBD) plasma with underwater bubbler treatment. S. aureus and E. coli in a suspension were reduced to less than 3.4 and 0.5 log CFU/ml after the plasma treatment for 3 min, respectively. On the perilla leaves, they were also reduced to 4.8 and 1.6 log CFU/ml after the plasma treatment, respectively. The S. aureus and E. coli bacterial cell wall was damaged by the plasma treatment evident by scanning electron microscopic analysis...
February 15, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29399293/anti-hyperglycemic-effects-and-signaling-mechanism-of-perilla-frutescens-sprout-extract
#11
Da-Hye Kim, Sang Jun Kim, Kang-Yeol Yu, Seung-Il Jeong, Seon-Young Kim
BACKGROUND/OBJECTIVES: Perilla frutescens (L.) Britton var . (PF) sprout is a plant of the labiate family. We have previously reported the protective effects of PF sprout extract on cytokine-induced β-cell damage. However, the mechanism of action of the PF sprout extract in type 2 diabetes (T2DM) has not been investigated. The present study was designed to study the effects of PF sprout extract and signaling mechanisms in the T2DM mice model using C57BL/KsJ-db/db (db/db) mice. MATERIALS/METHODS: Male db/db mice were orally administered PF sprout extract (100, 300, and 1,000 mg/kg of body weight) or rosiglitazone (RGZ, positive drug, 1 mg/kg of body weight) for 4 weeks...
February 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29371082/feasibility-of-using-a-bacteriophage-based-structural-color-sensor-for-screening-the-geographical-origins-of-agricultural-products
#12
Daun Seol, Jong-Sik Moon, Yujin Lee, Jiye Han, Daeil Jang, Dong-Jin Kang, Jiyoung Moon, Eunjin Jang, Jin-Woo Oh, Hoeil Chung
An M13 bacteriophage-based color sensor, which can change its structural color upon interaction with a gaseous molecule, was evaluated as a screening tool for the discrimination of the geographical origins of three different agricultural products (garlic, onion, and perilla). Exposure of the color sensor to sample odors induced the self-assembled M13 bacteriophage bundles to swell by the interaction of amino acid residues (repeating units of four glutamates) on the bacteriophage with the odor components, resulting in a change in the structural color of the sensor...
January 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29351555/omega-3-fatty-acid-desaturase-gene-family-from-two-%C3%AF-3-sources-salvia-hispanica-and-perilla-frutescens-cloning-characterization-and-expression
#13
Yufei Xue, Baojun Chen, Aung Naing Win, Chun Fu, Jianping Lian, Xue Liu, Rui Wang, Xingcui Zhang, Yourong Chai
Omega-3 fatty acid desaturase (ω-3 FAD, D15D) is a key enzyme for α-linolenic acid (ALA) biosynthesis. Both chia (Salvia hispanica) and perilla (Perilla frutescens) contain high levels of ALA in seeds. In this study, the ω-3 FAD gene family was systematically and comparatively cloned from chia and perilla. Perilla FAD3, FAD7, FAD8 and chia FAD7 are encoded by single-copy (but heterozygous) genes, while chia FAD3 is encoded by 2 distinct genes. Only 1 chia FAD8 sequence was isolated. In these genes, there are 1 to 6 transcription start sites, 1 to 8 poly(A) tailing sites, and 7 introns...
2018: PloS One
https://www.readbyqxmd.com/read/29331904/anthocyanins-in-perilla-plants-and-dried-leaves
#14
Yumi Fujiwara, Miya Kono, Airi Ito, Michiho Ito
High-quality perilla leaves are purple on upper and lower surfaces and have a good aroma. The Japanese Pharmacopoeia specifies the content of essential oils in perilla leaves but not that of anthocyanins. Several reports have described the chemical species of anthocyanins in red perilla, but a complete analysis of anthocyanins in perilla has not been reported. In this study, the anthocyanins in the leaves of cultivated and wild species of perilla and those in commercially available perilla herbs were studied...
March 2018: Phytochemistry
https://www.readbyqxmd.com/read/29331150/production-of-eicosapentaenoic-acid-by-application-of-a-delta-6-desaturase-with-the-highest-ala-catalytic-activity-in-algae
#15
Haisu Shi, Xue Luo, Rina Wu, Xiqing Yue
Dunaliella salina is a unicellular green alga with a high α-linolenic acid (ALA) level, but a low eicosapentaenoic acid (EPA) level. In a previous analysis of the catalytic activity of delta 6 fatty acid desaturase (FADS6) from various species, FADS6 from Thalassiosira pseudonana (TpFADS6), a marine diatom, showed the highest catalytic activity for ALA. In this study, to enhance EPA production in D. salina, FADS6 from D. salina (DsFADS6) was identified, and substrate specificities for DsFADS6 and TpFADS6 were characterized...
January 13, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29260378/%C3%AF-3-fatty-acid-synergized-novel-nanoemulsifying-system-for-rosuvastatin-delivery-in-vitro-and-in-vivo-evaluation
#16
Chandra Bhushan Tripathi, Neha Gupta, Pranesh Kumar, Ashok Kumar Singh, Vinit Raj, Poonam Parashar, Mahendra Singh, Jovita Kanoujia, Malti Arya, Shubhini A Saraf, Sudipta Saha
The present study was undertaken to improve rosuvastatin (RSV) bioavailability and pharmacological response through formation of SNES using Perilla frutescens oil as lipid carrier. The composition of oil was estimated by fatty acid methyl ester (FAME) analysis using gas chromatography. Solubility of RSV in Perilla frutescens oil and Cremophor EL was 25.0 ± 3.0 and 60.0 ± 5.0 mg/mL, respectively. Later, nanophasic maps and a central composite design were employed to determine the maximum nanoemulsion region and further optimize SNES in this study...
December 19, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29248943/edentulism-and-its-relationship-with-self-rated-health-secondary-analysis-of-the-sabe-ecuador-2009-study
#17
Miguel Germán Borda, Nicolás Castellanos-Perilla, Judy Andrea Patiño, Sandra Castelblanco, Carlos Alberto Cano, Diego Chavarro-Carvajal, Mario U Pérez-Zepeda
Edentulism is related to a number of conditions in older adults, impacting their overall health status and thus their quality of life and relationship with the environment. At the same time, self-rated health has been shown to be an accurate marker of overall health status. However there is little information on how edentulism relates to self-rated health in older adults of Hispanic origin. The aim of this study was to evaluate the impact of edentulism on self-rated health in older adults. We analyzed data from SABE Ecuador 2009, a cross-sectional study that included a probabilistic representative sample of 5, 235 community-dwelling older adults aged 60 years or older...
August 2017: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/29248449/interactions-between-crude-drug-extracts-used-in-japanese-traditional-kampo-medicines-and-organic-anion-transporting-polypeptide-2b1
#18
Rie Iijima, Tomoki Watanabe, Kan'ichiro Ishiuchi, Takashi Matsumoto, Junko Watanabe, Toshiaki Makino
ETHNOPHARMACOLOGICAL RELEVANCE: The use of herbal medicines has become popular worldwide, and the information on drug interactions between herbal medicines and chemical drugs is needed. AIM OF THE STUDY: We screened the inhibitory effects of crude drugs used in Kampo medicines used in Japan on organic anion-transporting polypeptide (OATP) 2B1 to predict potential interactions between Kampo medicines and chemical drugs used together. MATERIALS AND METHODS: We chose 98 kinds of crude drugs frequently used as ingredients of Kampo formulations in Japan and prepared their boiling water extracts...
March 25, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29246281/%C3%AE-lipoic-acid-ameliorated-oxidative-stress-induced-by-perilla-oil-but-the-combination-of-these-dietary-factors-was-ineffective-to-cause-marked-deceases-in-serum-lipid-levels-in-rats
#19
Takashi Ide, Ai Tanaka
Dietary perilla oil rich in α-linolenic acid and α-lipoic acid lowers the serum lipid level through changes in hepatic fatty acid metabolism. We therefore hypothesized that the combination of these dietary factors may ameliorate lipid metabolism more than the factors individually. Moreover, α-lipoic acid exerts strong anti-oxidative activity. Hence, we also hypothesized that α-lipoic acid may attenuate perilla oil-mediated oxidative stress. We therefore studied the combined effects of perilla oil and α-lipoic acid on lipid metabolism and parameters of oxidative stress...
December 2017: Nutrition Research
https://www.readbyqxmd.com/read/29239729/corrigendum-to-anti-inflammatory-effects-of-perillae-herba-ethanolic-extract-against-tnf-%C3%AE-ifn-%C3%AE-stimulated-human-keratinocyte-hacat-cells-j-ethnopharmacol-211-2018-217-223
#20
Ju-Hye Yang, Jae-Myung Yoo, Esther Lee, BoHyoung Lee, Won-Kyung Cho, Kwang-Il Park, Jin Yeul Ma
No abstract text is available yet for this article.
March 1, 2018: Journal of Ethnopharmacology
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