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https://www.readbyqxmd.com/read/28722007/physical-properties-of-the-hiv-1-capsid-from-all-atom-molecular-dynamics-simulations
#1
Juan R Perilla, Klaus Schulten
Human immunodeficiency virus type 1 (HIV-1) infection is highly dependent on its capsid. The capsid is a large container, made of ∼1,300 proteins with altogether 4 million atoms. Although the capsid proteins are all identical, they nevertheless arrange themselves into a largely asymmetric structure made of hexamers and pentamers. The large number of degrees of freedom and lack of symmetry pose a challenge to studying the chemical details of the HIV capsid. Simulations of over 64 million atoms for over 1 μs allow us to conduct a comprehensive study of the chemical-physical properties of an empty HIV-1 capsid, including its electrostatics, vibrational and acoustic properties, and the effects of solvent (ions and water) on the capsid...
July 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28718920/microcapsules-biologically-prepared-using-perilla-frutescens-l-britt-essential-oil-and-their-use-for-extension-of-fruit-shelf-life
#2
Na Li, Zhi-Jun Zhang, Xiao-Jun Li, Hui-Zhen Li, Li-Xia Cui, Dong-Liang He
BACKGROUND: Perilla EO possess high antioxidant, antimicrobial and insecticidal activities, and have proven to be more reliable than chemically synthesized food preservatives. Nevertheless, EOs have disadvantages of facile photo-degradation and oxidation which limits their use in agriculture and food industries. Microencapsulation technology that generates a polymeric coating surrounding EOs could overcome these disadvantages. RESUILS: The EO concentration had a significant effect on encapsulation efficiency (EE) and loading capacity (LC)...
July 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28710570/a-methoxyflavanone-derivative-from-the-asian-medicinal-herb-perilla-frutescens-induces-p53-mediated-g2-m-cell-cycle-arrest-and-apoptosis-in-a549-human-lung-adenocarcinoma
#3
Amer Ali Abd El-Hafeez, Takashi Fujimura, Rikiya Kamei, Noriko Hirakawa, Kenji Baba, Kazuhisa Ono, Seiji Kawamoto
Perilla frutescens is an Asian dietary herb consumed as an essential seasoning in Japanese cuisine as well as used for a Chinese medicine. Here, we report that a newly found methoxyflavanone derivative from P. frutescens (Perilla-derived methoxyflavanone, PDMF; 8-hydroxy-5,7-dimethoxyflavanone) shows carcinostatic activity on human lung adenocarcinoma, A549. We found that treatment with PDMF significantly inhibited cell proliferation and decreased viability through induction of G2/M cell cycle arrest and apoptosis...
July 14, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28622602/assessment-of-the-phenolic-profile-antimicrobial-activity-and-oxidative-stability-of-transgenic-perilla-frutescens-l-overexpressing-tocopherol-methyltransferase-%C3%AE-tmt-gene
#4
Bimal Kumar Ghimire, Chang Yeon Yu, Ill-Min Chung
This study evaluated the effects of enhanced concentrations of α-tocopherol and phenolic compounds on the resistance and stability of Perilla oil in transgenic Perilla frutescens plants against various tested pathogenic bacteria by over-expressing the γ-tmt gene. The concentration of phenolic compounds in the non-transgenic samples was 9313.198 ± 18.887 μg g(-1) dry weight (DW), whereas the total concentration of the transgenic samples ranged from 9118.015 ± 18.822 to 10527.612 ± 20.411 μg g(-1) DW...
June 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28523012/growth-and-accumulation-of-secondary-metabolites-in-perilla-as-affected-by-photosynthetic-photon-flux-density-and-electrical-conductivity-of-the-nutrient-solution
#5
Na Lu, Emmanuel L Bernardo, Chayanit Tippayadarapanich, Michiko Takagaki, Natsuko Kagawa, Wataru Yamori
The global demand for medicinal plants is increasing. The quality of plants grown outdoors, however, is difficult to control. Myriad environmental factors influence plant growth and directly impact biosynthetic pathways, thus affecting the secondary metabolism of bioactive compounds. Plant factories use artificial lighting to increase the quality of medicinal plants and stabilize production. Photosynthetic photon flux density (PPFD) and electrical conductivity (EC) of nutrient solutions are two important factors that substantially influence perilla (Perilla frutescens, Labiatae) plant growth and quality...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28515478/molecular-phylogenetics-and-biogeography-of-the-mint-tribe-elsholtzieae-nepetoideae-lamiaceae-with-an-emphasis-on-its-diversification-in-east-asia
#6
Pan Li, Zhe-Chen Qi, Lu-Xian Liu, Tetsuo Ohi-Toma, Joongku Lee, Tsung-Hsin Hsieh, Cheng-Xin Fu, Kenneth M Cameron, Ying-Xiong Qiu
Elsholtzia and its allied genera such as Collinsonia and Perilla (tribe Elsholtzieae, Lamiaceae) are an ecologically and economically important plant group consisting of ~71 species, with most species distributed in East and Southeast Asia, and several species in North America. Their phylogeny and historical biogeography resulting in a distant intercontinental disjunction are poorly understood. Here we use two nuclear (ETS, ITS) and five chloroplast (rbcL, matK, trnL-F, ycf1, ycf1-rps15) fragments to reconstruct the phylogeny, biogeographic history, and patterns of diversification of Elsholtzieae...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506035/simultaneous-molecular-detection-of-cryptosporidium-and-cyclospora-from-raw-vegetables-in-korea
#7
Seobo Sim, Jua Won, Jae-Whan Kim, Kyungjin Kim, Woo-Yoon Park, Jae-Ran Yu
Cryptosporidium and Cyclospora are well-known coccidian protozoa that can cause waterborne and foodborne diarrheal illnesses. There have been a few reports regarding contamination in different vegetables with Cryptosporidium, but no data are available regarding the sources of Cyclospora infections in Korea. In the present study, we collected 6 kinds of vegetables (perilla leaves, winter-grown cabbages, chives, sprouts, blueberries, and cherry tomatoes) from July 2014 to June 2015, and investigated contamination by these 2 protozoa using multiplex quantitative real-time PCR...
April 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28430157/development-of-user-friendly-method-to-distinguish-subspecies-of-the-korean-medicinal-herb-perilla-frutescens-using-multiplex-pcr
#8
Yonguk Kim, Ah-Young Kim, Ara Jo, Hakjoon Choi, Seung-Sik Cho, Chulyung Choi
Perilla (Perilla frutescens) is an economically and culturally important plant in East Asia. Plant breeding between cultivars has enhanced the genetic diversity of perilla overall, but means that functionally diverse subspecies are more difficult to identify and distinguish. In this study, we developed gene-based DNA markers to distinguish between the Korean herbal medicinal perilla varieties. We identified informative simple sequence repeat (SSR) regions on the promoter regions of the Myb-P1 and dihydroflavonol 4-reductase (DFR) genes, as well as a large insertion-deletion (indel) region in the limonene synthase (LS) gene, and developed markers to characterize the distinct subspecies differences (PfMyb-P1pro, PfDFRpro, and PfLS, respectively)...
April 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28383063/rosmarinic-acid-suppresses-colonic-inflammation-in-dextran-sulphate-sodium-dss-induced-mice-via-dual-inhibition-of-nf-%C3%AE%C2%BAb-and-stat3-activation
#9
Bo-Ram Jin, Kyung-Sook Chung, Se-Yun Cheon, Minho Lee, Soonjae Hwang, Sam Noh Hwang, Ki-Jong Rhee, Hyo-Jin An
Ulcerative colitis (UC), a type of inflammatory bowel disease (IBD), is a chronic inflammatory disorder of the colon. Although UC is generally treated with anti-inflammatory drugs or immunosuppressants, most of these treatments often prove to be inadequate. Rosmarinic acid (RA) is a phenolic ester included in various medicinal herbs such as Salvia miltiorrhiz and Perilla frutescens. Although RA has many biological and pharmacological activities, the anti-inflammatory effect of RA in colonic tissue remains unclear...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28380360/the-mutational-landscape-of-circulating-tumor-cells-in-multiple-myeloma
#10
Yuji Mishima, Bruno Paiva, Jiantao Shi, Jihye Park, Salomon Manier, Satoshi Takagi, Mira Massoud, Adriana Perilla-Glen, Yosra Aljawai, Daisy Huynh, Aldo M Roccaro, Antonio Sacco, Marzia Capelletti, Alexandre Detappe, Diego Alignani, Kenneth C Anderson, Nikhil C Munshi, Felipe Prosper, Jens G Lohr, Gavin Ha, Samuel S Freeman, Eliezer M Van Allen, Viktor A Adalsteinsson, Franziska Michor, Jesus F San Miguel, Irene M Ghobrial
The development of sensitive and non-invasive "liquid biopsies" presents new opportunities for longitudinal monitoring of tumor dissemination and clonal evolution. The number of circulating tumor cells (CTCs) is prognostic in multiple myeloma (MM), but there is little information on their genetic features. Here, we have analyzed the genomic landscape of CTCs from 29 MM patients, including eight cases with matched/paired bone marrow (BM) tumor cells. Our results show that 100% of clonal mutations in patient BM were detected in CTCs and that 99% of clonal mutations in CTCs were present in BM MM...
April 4, 2017: Cell Reports
https://www.readbyqxmd.com/read/28374423/effect-of-6-gingerol-on-physicochemical-properties-of-grass-carp%C3%A2-ctenopharyngodon-idellus-surimi-fortified-with-perilla-oil-during-refrigerated-storage
#11
Hongbo Mi, Bo Zhao, Cong Wang, Shumin Yi, Yongxia Xu, Jianrong Li
BACKGROUND: Surimi is produced from deboned fish muscle through being washed to remove blood, lipids, sarcoplasmic proteins, and other impurities. There is an increasing interest in the fortification of surimi with ω-3 PUFAs because of their health benefits. However, lipid oxidation should be considered as an important factor during storage. Hence, in this study, the quality properties and oxidative stability of surimi fortified with 30 g kg(-1) perilla oil (PO), or 5 g kg(-1) 6-gingerol (GI) or their combination (PO+GI) was investigated...
April 4, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28278651/pollination-effects-on-antioxidant-content-of-perilla-frutescens-seeds-analysed-by-nmr-spectroscopy
#12
Paola Ferrazzi, Monica Vercelli, Amina Chakir, Abderrahmane Romane, Monica Mattana, Roberto Consonni
The effects of Perilla frutescens pollination on the content of seed antioxidants were analysed by agronomical and pollination trials, comparing seeds produced from bagged plants in 2013 (A) to prevent access to pollinating insects, and seeds from open-pollinated plants in 2013 (B) and 2015 (C). The seeds of open-pollinated plants were significantly more numerous and heavier than those of self-pollinated plants. (1)H NMR seed analysis showed a higher presence of phenolic compounds in open-pollinated seeds, mainly rosmarinic acid and flavonoids, apigenin and luteolin...
February 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28224196/calcium-and-oxidative-stress-mediate-perillaldehyde-induced-apoptosis-in-candida-albicans
#13
Hui Tian, Su Qu, Yanzhen Wang, Zhaoqun Lu, Man Zhang, Yeyun Gan, Peng Zhang, Jun Tian
New anti-Candida albicans drugs are needed due to the emergence of resistant cases in recent years. Perillaldehyde (PAE) is a natural monoterpenoid compound derived from Perilla frutescens. The minimum inhibitory concentration of PAE against C. albicans was 0.4 μL/mL. We aimed to elucidate the antifungal mode of action of PAE against C. albicans. The antifungal activity of PAE against C. albicans was found to correlate with an elevation in intracellular Ca(2+) and accumulation of ROS. Several downstream apoptosis events such as the disruption of mitochondrial membrane potential, phosphatidylserine externalization, cytochrome c release, and metacaspase activation were observed in PAE-treated cells...
April 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28218690/comparison-of-the-anti-inflammatory-activities-of-supercritical-carbon-dioxide-versus-ethanol-extracts-from-leaves-of-perilla-frutescens-britt-radiation-mutant
#14
Chang Hyun Jin, Han Chul Park, Yangkang So, Bomi Nam, Sung Nim Han, Jin-Baek Kim
In this study, we aimed to compare supercritical carbon dioxide extraction and ethanol extraction for isoegomaketone (IK) content in perilla leaf extracts and to identify the optimal method. We measured the IK concentration using HPLC and inflammatory mediators in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells from the extracts. The IK concentration was 10-fold higher in perilla leaf extracts by supercritical carbon dioxide extraction (SFE) compared with that in perilla leaf extracts by ethanol extraction (EE)...
February 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28208640/rapid-high-performance-liquid-chromatography-determination-and-optimization-of-extraction-parameters-of-the-%C3%AE-asarone-isolated-from-perilla-frutescens-l
#15
Seung Hwan Hwang, Shin Hwa Kwon, Young-Hee Kang, Jae-Yong Lee, Soon Sung Lim
Response surface methodology (RSM), based on a central composite design, was used to determine the best liquid-to-raw material ratio (10:3-15 mL/g), extraction time (1-3 h), and ethanol concentration (50%-100%) for maximum content of α-asarone from Perilla frutescens (PF) extract. Experimental values of α-asarone were 9.51-46.36 mg/g; the results fitted a second-order quadratic polynomial model and correlated with the proposed model (R2 > 0.9354). The best conditions were obtained with extraction time of 1...
February 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28192760/competitive-binding-experiments-can-reduce-the-false-positive-results-of-affinity-based-ultrafiltration-hplc-a-case-study-for-identification-of-potent-xanthine-oxidase-inhibitors-from-perilla-frutescens-extract
#16
Zhiqiang Wang, Shin Hwa Kwon, Seung Hwan Hwang, Young-Hee Kang, Jae-Yong Lee, Soon Sung Lim
The purpose of this study was to assess the possibility of using competitive binding experiments with ultrafiltration-HPLC analysis to identify potent xanthine oxidase (XO) inhibitors from the Perilla frutescens extract as an attempt to reduce the number of false positive results. To isolate the enzyme-ligand complex from unbound compounds, the P. frutescens extract was either incubated in the absence of XO, in the presence of XO, or with the active site blocked XO before the ultrafiltration was performed. Allopurinaol was used as the XO active site blocker...
March 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28181439/cryoem-structure-refinement-by-integrating-nmr-chemical-shifts-with-molecular-dynamics-simulations
#17
Juan R Perilla, Gongpu Zhao, Manman Lu, Jiying Ning, Guangjin Hou, In-Ja L Byeon, Angela M Gronenborn, Tatyana Polenova, Peijun Zhang
Single particle cryoEM has emerged as a powerful method for structure determination of proteins and complexes, complementing X-ray crystallography and NMR spectroscopy. Yet, for many systems, the resolution of cryoEM density map has been limited to 4-6 Å, which only allows for resolving bulky amino acids side chains, thus hindering accurate model building from the density map. On the other hand, experimental chemical shifts (CS) from solution and solid state MAS NMR spectra provide atomic level data for each amino acid within a molecule or a complex; however, structure determination of large complexes and assemblies based on NMR data alone remains challenging...
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28167258/protective-effect-of-nrf2-are-activator-isolated-from-green-perilla-leaves-on-dopaminergic-neuronal-loss-in-a-parkinson-s-disease-model
#18
Yuta Masaki, Yasuhiko Izumi, Atsuko Matsumura, Akinori Akaike, Toshiaki Kume
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra (SN), and oxidative stress is thought to contribute to the pathogenesis. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway, which is a cellular defense system against oxidative stress, is a promising target for therapeutics aimed at reducing neuronal death in PD. Previously, we have isolated 2',3'-dihydroxy-4',6'-dimethoxychalcone (DDC) from green perilla leaves as an activator of the Nrf2-ARE pathway...
March 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28149172/yield-size-nutritional-value-and-antioxidant-activity-of-oyster-mushrooms-grown-on-perilla-stalks
#19
Huizhen Li, Zhijun Zhang, Mengxue Li, Xiaojun Li, Ziwen Sun
Perilla is an edible medical plant with rapidly increasing acreage in China. In this study, we investigated the potential of perilla stalks (PSs) as an alternative substrate for the cultivation of oyster mushrooms (Pleurotus ostreatus). P. ostreatus was cultivated on cottonseed hulls (CSH) alone or mixed with PSs in different ratios. The production parameters, physical characteristics, nutritional values, and antioxidant activity of mushrooms cultivated on different substrate mixtures were determined. The addition of PSs to CSH significantly improved the growth rate, yield, biological efficiency, and proximate composition and shortened the cultivation cycle...
February 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28124802/the-interventional-relationship-between-frequent-fish-consumption-and-depression-symptoms-in-aging-adults-a-randomized-controlled-trial
#20
Payam Sharifan, Motahare-Sadat Hosseini, Anoosheh Sharifan
OBJECTIVE: The present investigation was intended to test the hypothesis that the elderly provided with the frequent consumption of fishes marinated in essential oil of Perilla frutescens (EOPF) or not would experience fewer depressive symptoms after 6 months. METHODS: A total of 180 participants were recruited from Sina Hospital, Mashhad, Iran, who were diagnosed with depression based on Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision and Beck Depression Inventory...
January 26, 2017: International Journal of Geriatric Psychiatry
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