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https://www.readbyqxmd.com/read/28088783/%C3%AE-asarone-blocks-7%C3%AE-hydroxycholesterol-exposed-macrophage-injury-through-blocking-elf2%C3%AE-phosphorylation-and-prompting-beclin-1-dependent-autophagy
#1
Sin-Hye Park, Min-Kyung Kang, Yean-Jung Choi, Yun-Ho Kim, Lucia Dwi Antika, Dong Yeon Kim, Eun-Jung Lee, Soon Sung Lim, Young-Hee Kang
Macrophage apoptosis is salient in advanced atherosclerotic lesions and is induced by several stimuli including endoplasmic reticulum (ER) stress. This study examined that α-asarone present in purple perilla abrogated macrophage injury caused by oxysterols via ER stress- and autophagy-mediated mechanisms. Nontoxic α-asarone at 1-20 μM attenuated 7β-hydroxycholesterol-induced activation of eukaryotic initiation factor 2α in macrophages leading to C/EBP homologous protein (CHOP) expression and apoptosis due to sustained ER stress...
January 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28073960/ligand-characterization-of-cyp4b1-isoforms-modified-for-high-level-expression-in-escherichia-coli-and-hepg2-cells
#2
Katharina Roellecke, Vera D Jäger, Veselin H Gyurov, John P Kowalski, Stephanie Mielke, Allan E Rettie, Helmut Hanenberg, Constanze Wiek, Marco Girhard
Human CYP4B1, a cytochrome P450 monooxygenase predominantly expressed in the lung, inefficiently metabolizes classical CYP4B1 substrates, such as the naturally occurring furan pro-toxin 4-ipomeanol (4-IPO). Highly active animal forms of the enzyme convert 4-IPO to reactive alkylating metabolite(s) that bind(s) to cellular macromolecules. By substitution of 13 amino acids, we restored the enzymatic activity of human CYP4B1 toward 4-IPO and this modified cDNA is potentially valuable as a suicide gene for adoptive T-cell therapies...
January 10, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/27986566/a-flavanone-derivative-from-the-asian-medicinal-herb-perilla-frutescens-potently-suppresses-ige-mediated-immediate-hypersensitivity-reactions
#3
Rikiya Kamei, Takashi Fujimura, Miki Matsuda, Kotaro Kakihara, Noriko Hirakawa, Kenji Baba, Kazuhisa Ono, Kenji Arakawa, Seiji Kawamoto
Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P. frutescens phytochemical that potently suppresses IgE-mediated type I hypersensitivity reactions. Structural analysis reveals that the purified anti-allergic compound (Perilla-derived methoxyflavanone, PDMF) is identified as 8-hydroxy-5,7-dimethoxyflavanone. PDMF significantly inhibits IgE-mediated histamine release from RBL-2H3 rat basophilic leukemia cells as compared with those seen in known P...
December 13, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27976251/determination-of-fatty-acids-from-perilla-cultivars-and-edible-oils-by-gc-fid
#4
J Lee, S Cho, J P Rodriguez, K H Lee, T Jin, M H Lee, E J Cho, S Lee
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975746/neuroprotective-effect-of-perilla-extracts-on-pc12-cells
#5
P Senavong, S Kongkham, S Saelim, V Suangkavathin
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975407/simultaneous-determination-of-phytochemicals-from-the-seeds-of-perilla-cultivars
#6
J Lee, S Cho, J P Rodriguez, K H Lee, T Jin, M H Lee, E J Cho, S Lee
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27958644/effect-of-perilla-frutescens-extracts-on-porcine-jejunal-epithelial-cells
#7
Christine M Kaufmann, Thomas Letzel, Johanna Grassmann, Michael W Pfaffl
Green-leaved Perilla frutescens extracts were investigated on their effect on cell proliferation of the porcine jejunal epithelial cell line, IPEC-J2, as well as on the gene expression of cell cycle or cancer-related genes. Some extracted compounds were, however, susceptible to degradation in cell culture medium, whereas others were found to be stable during the entire experimental time. Control experiments also included the assessment of H2 O2 generation in cell culture medium caused by oxidation of natural extract compounds, which was proved to be absent at low extract concentrations...
December 13, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27890582/molecular-cloning-and-characterization-of-a-perilla-frutescens-cytochrome-p450-enzyme-that-catalyzes-the-later-steps-of-perillaldehyde-biosynthesis
#8
Yumi Fujiwara, Michiho Ito
Perilla produces the cyclohexanoid monoterpene perillaldehyde as a major constituent of an essential oil that is accumulated in its glandular trichomes. Perillaldehyde is a marker compound for quality control of soyo and has biological activities such as antibacterial, sedative, or vasodilatory effects. The predicted perillaldehyde formation involves the cyclization of geranyl diphosphate, hydroxylation, and oxidation, and cytochrome P450 plays a crucial role in perillaldehyde biosynthesis. In this study, a cytochrome P450-type enzyme with perillyl alcohol and perillaldehyde synthase activities was isolated by analyzing an expressed sequence tag library from several oil types of pure lines of perilla...
February 2017: Phytochemistry
https://www.readbyqxmd.com/read/27890564/phytochemical-and-phytopharmacological-review-of-perilla-frutescens-l-labiatae-a-traditional-edible-medicinal-herb-in-china
#9
Hua Yu, Jian-Feng Qiu, Li-Juan Ma, Yuan-Jia Hu, Peng Li, Jian-Bo Wan
Perilla frutescens (L.) Britt., a worldwide distributed plant, is an important economic crop and with a long cultivation history in China as well as some other countries in Asia. Except for the edible applications, the plant of P. frutescens is also traditionally used as a medicinal herb in China for thousands years. The leaves, seeds and stems of P. frutescens are recommended by the Chinese Pharmacopeia as three medicinal materials for various therapeutic applications. In the past decades, amount investigations have been done about different aspects for P...
November 24, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27888134/perilla-frutescens-leaves-extract-ameliorates-ultraviolet-radiation-induced-extracellular-matrix-damage-in-human-dermal-fibroblasts-and-hairless-mice-skin
#10
Jung-Soo Bae, Mira Han, Hee Soon Shin, Min-Kyoung Kim, Chang-Yup Shin, Dong Hun Lee, Jin Ho Chung
ETHNOPHARMACOLOGICAL RELEVANCE: Perilla frutescens (L.) Britt. (Lamiaceae) is a traditional herb that is consumed in East Asian countries as a traditional medicine. This traditional herb has been documented for centuries to treat various diseases such as depression, allergies, inflammation and asthma. However, the effect of Perilla frutescens on skin has not been characterized well. AIM OF THE STUDY: The present study aimed to investigate the effect of Perilla frutescens leaves extract (PLE) on ultraviolet radiation-induced extracellular matrix damage in human dermal fibroblasts and hairless mice skin...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27842727/minimization-of-diauxic-growth-lag-phase-for-high-efficiency-biogas-production
#11
Min Jee Kim, Sang Hun Kim
The objective of this study was to develop a minimization method of a diauxic growth lag-phase for the biogas production from agricultural by-products (ABPs). Specifically, the effects of proximate composition on the biogas production and degradation rates of the ABPs were investigated, and a new method based on proximate composition combinations was developed to minimize the diauxic growth lag-phase. Experiments were performed using biogas potential tests at a substrate loading of 2.5 g VS/L and feed to microorganism ratio (F/M) of 0...
February 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27752499/anti-adipogenic-effects-of-ethanol-extracts-prepared-from-selected-medicinal-herbs-in-3t3-l1-cells
#12
Min-Jun Park, Ji-Hye Song, Myung-Soo Shon, Hae Ok Kim, O Jun Kwon, Seong-Soo Roh, Choon Young Kim, Gyo-Nam Kim
Obesity is a major risk factor for various metabolic diseases such as cardiovascular disease, hypertension, and type 2 diabetes mellitus. In this study, we prepared ethanol extracts from Agastache rugosa (ARE), Chrysanthemum zawadskii (CZE), Mentha arvensis (MAE), Perilla frutescens (PFE), Leonurus sibiricus (LSE), Gardenia jasminoides (GJE), and Lycopus coreanus (LCE). The anti-oxidant and anti-adipogenic effects were evaluated. The IC50 values for ascorbic acid and LCE against 2,2-diphenyl-1-picrylhydrazyl radicals were 246...
September 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/27729934/anti-atherosclerotic-effects-of-perilla-oil-in-rabbits-fed-a-high-cholesterol-diet
#13
Yeseul Cha, Ja Young Jang, Young-Hwan Ban, Haiyu Guo, Kyungha Shin, Tae-Su Kim, Sung-Pyo Lee, Jieun Choi, Eun-Suk An, Da-Woom Seo, Jung-Min Yon, Ehn-Kyoung Choi, Yun-Bae Kim
Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD containing 0.5% cholesterol and 1% corn oil, and perilla oil (0.1 or 0.3%) was added to the diet containing 0.5% cholesterol for 10 weeks. HCD greatly increased blood total cholesterol and low-density lipoproteins, and caused thick atheromatous plaques, covering 74% of the aortic wall. Hyper-cholesterolemia also induced lipid accumulation in the liver and kidneys, leading to lipid peroxidation...
September 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27701859/hiv-1-capsid-function-is-regulated-by-dynamics-quantitative-atomic-resolution-insights-by-integrating-magic-angle-spinning-nmr-qm-mm-and-md
#14
Huilan Zhang, Guangjin Hou, Manman Lu, Jinwoo Ahn, In-Ja L Byeon, Christopher J Langmead, Juan R Perilla, Ivan Hung, Peter L Gor'kov, Zhehong Gan, William W Brey, David A Case, Klaus Schulten, Angela M Gronenborn, Tatyana Polenova
HIV-1 CA capsid protein possesses intrinsic conformational flexibility, which is essential for its assembly into conical capsids and interactions with host factors. CA is dynamic in the assembled capsid, and residues in functionally important regions of the protein undergo motions spanning many decades of timescales. Chemical shift anisotropy (CSA) tensors, recorded in magic-angle-spinning NMR experiments, provide direct residue-specific probes of motions on nano- to microsecond timescales. We combined NMR, MD, and Density-Functional-Theory calculations, to gain quantitative understanding of internal backbone dynamics in CA assemblies, and found that the dynamically averaged (15)N CSA tensors calculated by this joined protocol are in remarkable agreement with experiment...
October 5, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27696934/effects-of-vegetable-oils-with-different-fatty-acid-compositions-on-cognition-and-memory-ability-in-a%C3%AE-25-35-induced-alzheimer-s-disease-mouse-model
#15
Ah Young Lee, Ji Myung Choi, Jaemin Lee, Myoung Hee Lee, Sanghyun Lee, Eun Ju Cho
In this study, we aimed to investigate the protective effect of three kinds of vegetable oils with different fatty acid compositions against cognitive impairment in an Alzheimer's disease (AD) mouse model. After intracerebroventricular injection of amyloid beta25-35 (Aβ25-35) into the brain of institute of cancer research mice, olive oil (rich in oleic acid, C18:1), corn oil (rich in linoleic acid, C18:2), and perilla oil (rich in α-linolenic acid [ALA], C18:3) were administered at the oral dose of 500 mg/kg/day for 14 days...
October 3, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27692886/uptake-and-subcellular-distribution-of-triclosan-in-typical-hydrophytes-under-hydroponic-conditions
#16
Yupeng He, Enguang Nie, Chengming Li, Qingfu Ye, Haiyan Wang
The increasing discharge of pharmaceuticals and personal care products (PPCPs) into the environment has generated serious public concern. The recent awareness of the environmental impact of this emerging class of pollutants and their potential adverse effects on human health have been documented in many reports. However, information regarding uptake and intracellular distribution of PPCPs in hydrophytes under hydroponic conditions, and potential human exposure is very limited. A laboratory experiment was conducted using (14)C-labeled triclosan (TCS) to investigate uptake and distribution of TCS in six aquatic plants (water spinach, purple perilla, cress, penny grass, cane shoot, and rice), and the subcellular distribution of (14)C-TCS was determined in these plants...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27664540/molecular-cloning-and-characterization-of-unfolded-protein-response-genes-from-large-yellow-croaker-larimichthys-crocea-and-their-expression-in-response-to-dietary-fatty-acids
#17
Kai Liao, Jing Yan, Songlin Li, Tianjiao Wang, Wei Xu, Kangsen Mai, Qinghui Ai
The unfolded protein response (UPR) is a mechanism to cope with perturbed endoplasmic reticulum (ER) functions or accumulation of unfolded protein in the ER in eukaryotic cells. Furthermore, the UPR also participates in a number of physiological and pathological processes, such as nutrient sensing, lipid synthesis, and inflammatory response. In this study, four UPR-related genes (GRP78/BiP, ATF6α, XBP1 and CHO) were isolated characterized from large yellow croaker (Larimichthys crocea), and their expression in response to dietary lipid sources (various fatty acids) such as fish oil (FO), palmic acid (PA), olive oil (OO), sunflower oil (SO), and perilla oil (PO), were examined following feeding...
January 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27660180/medicinal-herbs-as-a-potential-strategy-to-decrease-methane-production-by-rumen-microbiota-a-systematic-evaluation-with-a-focus-on-perilla-frutescens-seed-extract
#18
Jiakun Wang, Mei Liu, Yuelei Wu, Liang Wang, Jianxin Liu, Linshu Jiang, Zhongtang Yu
Mitigation of the methane (CH4) emission from ruminants is needed to decrease the environmental impact of ruminant animal production. Different plant materials and chemicals have been tested, but few are both effective and practical. Medicinal herbs contain biological compounds and antimicrobials that may be effective in lowering the CH4 production. However, few studies have systematically evaluated medicinal herbs for their effect on CH4 production or on the rumen microbiota. In this study, extracts from 100 medicinal herbs were assessed for their ability to decrease CH4 production by rumen microbiota in vitro...
November 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27642591/perilla-oil-supplementation-ameliorates-high-fat-high-cholesterol-diet-induced-nonalcoholic-fatty-liver-disease-in-rats-via-enhanced-fecal-cholesterol-and-bile-acid-excretion
#19
Ting Chen, Fahu Yuan, Hualin Wang, Yu Tian, Lei He, Yang Shao, Na Li, Zhiguo Liu
Recent experimental studies and clinical trials have shown that hepatic cholesterol metabolic disorders are closely related to the development of nonalcoholic fatty liver disease (NAFLD). The main goal of this study was to investigate the efficacy of the perilla oil rich in alpha-linolenic acid (ALA) against NASH and gain a deep insight into its potential mechanisms. Rats were fed a high-fat/high-cholesterol diet (HFD) supplement with perilla oil (POH) for 16 weeks. Routine blood biochemical tests and histological staining illustrated that the perilla oil administration improved HFD-induced hyperlipidemia, reduced hepatic steatosis, and inhibited hepatic inflammatory infiltration and fibrosis...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27637203/functional-identification-of-oleate-12-desaturase-and-%C3%AF-3-fatty-acid-desaturase-genes-from-perilla-frutescens-var-frutescens
#20
Kyeong-Ryeol Lee, Yongjik Lee, Eun-Ha Kim, Seul-Bee Lee, Kyung Hee Roh, Jong-Bum Kim, Han-Chul Kang, Hyun Uk Kim
We described identification, expression, subcellular localization, and functions of genes that encode fatty acid desaturase enzymes in Perilla frutescens var. frutescens. Perilla (Perilla frutescens var. frutescens) seeds contain approximately 40 % of oil, of which α-linolenic acid (18:3) comprise more than 60 % in seed oil and 56 % of total fatty acids (FAs) in leaf, respectively. In perilla, endoplasmic reticulum (ER)-localized and chloroplast-localized ω-3 FA desaturase genes (PfrFAD3 and PfrFAD7, respectively) have already been reported, however, microsomal oleate 12-desaturase gene (PfrFAD2) has not yet...
December 2016: Plant Cell Reports
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