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https://www.readbyqxmd.com/read/27933371/phase-i-clinical-and-pharmacokinetic-study-of-s-1-plus-oral-leucovorin-in-patients-with-metastatic-colorectal-cancer
#1
Takayuki Yoshino, Ichinosuke Hyodo, Tomohiro Nishina, Hiroyuki Narahara, Naotoshi Sugimoto, Kunihiro Yoshisue, Narikazu Boku
PURPOSE: S-1 has shown a response rate of 35% in chemonaïve patients with metastatic colorectal cancer (mCRC). Leucovorin enhances the antitumor activity of 5-fluorouracil, and concurrent oral administration of S-1 and leucovorin may represent a more active treatment option for mCRC. METHODS: S-1 (35 mg/m(2)) and leucovorin (25 mg/body) were orally administered twice daily to chemonaïve patients with mCRC. Predefined dose (schedule)-limiting toxicities (DLTs) during the first course and treatment continuity during the first two courses were evaluated during three periods of treatment with S-1 plus leucovorin (level 0, 2 weeks; level 1, 3 weeks; and level 2, 4 weeks), each followed by a 2-week rest...
December 8, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27933315/immunogenicity-of-self-tumor-associated-proteins-is-enhanced-through-protein-truncation
#2
Tim Kottke, Kevin G Shim, Vanesa Alonso-Camino, Shane Zaidi, Rosa Maria Diaz, Jose Pulido, Jill Thompson, Karishma R Rajani, Laura Evgin, Elizabeth Ilett, Hardev Pandha, Kevin Harrington, Peter Selby, Alan Melcher, Richard Vile
We showed previously that therapy with Vesicular Stomatitis Virus (VSV) expressing tumor-associated proteins eradicates established tumors. We show here that when cellular cDNA were cloned into VSV which retained their own poly-A signal, viral species emerged in culture which had deleted the cellular poly-A signal and also contained a truncated form of the protein coding sequence. Typically, the truncation occurred such that a Tyrosine-encoding codon was converted into a STOP codon. We believe that the truncation of tumor-associated proteins expressed from VSV in this way occurred to preserve the ability of the virus to replicate efficiently...
2016: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/27933076/overexpression-of-tanac2d-displays-opposite-responses-to-abiotic-stresses-between-seedling-and-mature-stage-of-transgenic-arabidopsis
#3
Quanjun Huang, Yan Wang
Environmental stresses frequently affect plant growth and development, and many genes have been found to be induced by unfavorable environmental conditions. Here, we reported the biological functions of TaNAC2D, a stress-related NAC (NAM, ATAF, and CUC) gene from wheat. TaNAC2D showed transcriptional activator activity in yeast. TaNAC2D-GFP fusion protein was localized in the nucleus of wheat mesophyll protoplasts. TaNAC2D transcript abundance was significantly induced by NaCl, PEG6000, and abscisic acid (ABA) at seedling stage, and repressed by NaCl and PEG6000 at mature plant stage...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27927282/effect-of-sodium-hypochlorite-and-ricinus-communis-solutions-on-control-of-denture-biofilm-a-randomized-crossover-clinical%C3%A2-trial
#4
Carolina Noronha Ferraz de Arruda, Marcela Moreira Salles, Maurício Malheiros Badaró, Viviane de Cássia Oliveira, Ana Paula Macedo, Cláudia Helena Silva-Lovato, Helena de Freitas Oliveira Paranhos
STATEMENT OF PROBLEM: The prevalence of complete edentulism remains high in the elderly, and previous data have shown that poor denture hygiene is common among edentulous patients. PURPOSE: The purpose of this randomized crossover trial was to evaluate the efficacy of denture cleansers in terms of biofilm removal, antimicrobial action, and the remission of denture stomatitis. MATERIAL AND METHODS: Fifty denture wearers with denture stomatitis were instructed to brush their dentures (brush and soap) and to soak them (20 minutes/14 days) in 4 solutions, as follows: C (control), 0...
December 4, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27926860/l-met-activates-arabidopsis-glr-ca-2-channels-upstream-of-ros-production-and-regulates-stomatal-movement
#5
Dongdong Kong, Heng-Cheng Hu, Eiji Okuma, Yuree Lee, Hui Sun Lee, Shintaro Munemasa, Daeshik Cho, Chuanli Ju, Leah Pedoeim, Barbara Rodriguez, Juan Wang, Wonpil Im, Yoshiyuki Murata, Zhen-Ming Pei, June M Kwak
Plant glutamate receptor homologs (GLRs) have long been proposed to function as ligand-gated Ca(2+) channels, but no in planta evidence has been provided. Here, we present genetic evidence that Arabidopsis GLR3.1 and GLR3.5 form Ca(2+) channels activated by L-methionine (L-Met) at physiological concentrations and regulate stomatal apertures and plant growth. The glr3.1/3.5 mutations resulted in a lower cytosolic Ca(2+) level, defective Ca(2+)-induced stomatal closure, and Ca(2+)-deficient growth disorder, all of which involved L-Met...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27925291/herbivore-perception-decreases-photosynthetic-carbon-assimilation-and-reduces-stomatal-conductance-by-engaging-12-oxo-phytodienoic-acid-mitogen-activated-protein-kinase-4-and-cytokinin-perception
#6
Ivan D Meza-Canales, Stefan Meldau, Jorge A Zavala, Ian T Baldwin
Herbivory-induced changes in photosynthesis have been documented in many plant species, however the complexity of photosynthetic regulation and analysis has thwarted progress in understanding the mechanism involved, particularly those elicited by herbivore-specific elicitors. Here we analyzed the early photosynthetic gas-exchange responses in Nicotiana attenuata plants after wounding and elicitation with Manduca sexta oral-secretions, and the pathways regulating these responses. Elicitation with M. sexta oral-secretions rapidly decreased photosynthetic carbon-assimilation (AC ) in treated and systemic (untreated, vascularly connected) leaves, which were associated with changes in stomatal conductance, rather than with changes in Rubisco activity and RuBP-turnover...
December 7, 2016: Plant, Cell & Environment
https://www.readbyqxmd.com/read/27925232/estimating-the-sensitivity-of-stomatal-conductance-to-photosynthesis-a-review
#7
REVIEW
Grace L Miner, William L Bauerle, Dennis D Baldocchi
A common approach for estimating fluxes of CO2 and water in canopy models is to couple a model of photosynthesis (An ) (e.g., Farquhar et al., 1980) to a semi-empirical model of stomatal conductance (gs ) such as the widely validated and utilized Ball-Berry (BB) model (e.g., Ball et al., 1987). This coupling provides an effective way of predicting transpiration at multiple scales. However, the designated value of the slope parameter (m) in the BB model impacts transpiration estimates. There is a lack of consensus regarding how m varies among species or plant functional types (PFTs) or in response to growth conditions...
December 6, 2016: Plant, Cell & Environment
https://www.readbyqxmd.com/read/27924923/genome-wide-analysis-of-phosphoenolpyruvate-carboxylase-gene-family-and-their-response-to-abiotic-stresses-in-soybean
#8
Ning Wang, Xiujuan Zhong, Yahui Cong, Tingting Wang, Songnan Yang, Yan Li, Junyi Gai
Phosphoenolpyruvate carboxylase (PEPC) plays an important role in assimilating atmospheric CO2 during C4 and crassulacean acid metabolism photosynthesis, and also participates in various non-photosynthetic processes, including fruit ripening, stomatal opening, supporting carbon-nitrogen interactions, seed formation and germination, and regulation of plant tolerance to stresses. However, a comprehensive analysis of PEPC family in Glycine max has not been reported. Here, a total of ten PEPC genes were identified in soybean and denominated as GmPEPC1-GmPEPC10...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924664/assessment-of-ethnic-differences-in-sunitinib-outcome-between-caucasian-and-asian-patients-with-metastatic-renal-cell-carcinoma-a-meta-analysis
#9
Xiaoyan Liu, Marta Fiocco, Jesse J Swen, Henk-Jan Guchelaar
BACKGROUND: An increasing number of studies have reported ethnic differences in sunitinib outcome in metastatic renal cell carcinoma (mRCC) patients. However, a comprehensive analysis is still lacking. Therefore, we systematically collected available published data and performed a meta-analysis to compare sunitinib efficacy and toxicity in Asian and Caucasian mRCC patients. METHODS: Data were extracted from published results from clinical trials, expanded access program and real-world clinical practice...
December 7, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27924133/optimization-of-in-vitro-and-ex-vitro-regeneration-and-micromorphological-studies-in-basella-alba-l
#10
Mahipal S Shekhawat, M Manokari
The optimum concentrations of the plant hormones for in vitro regeneration and subsequent effect of auxins on rooting (in vitro and ex vitro) of shoots of Basella alba L. have been investigated in present study. Nodal shoot segments were used as explants to initiate the cultures. The bud breaking from explants was observed within 1 week of incubation on agar gelled Murashige and Skoog's (MS) medium. Multiple axillary shoots (7.30 ± 0.56 shoots per explant) were induced on MS medium supplemented with 2.0 mg/L 6-benzylaminopurine (BAP)...
October 2016: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/27923039/natural-variation-in-arabidopsis-cvi-0-accession-reveals-an-important-role-of-mpk12-in-guard-cell-co2-signaling
#11
Liina Jakobson, Lauri Vaahtera, Kadri Tõldsepp, Maris Nuhkat, Cun Wang, Yuh-Shuh Wang, Hanna Hõrak, Ervin Valk, Priit Pechter, Yana Sindarovska, Jing Tang, Chuanlei Xiao, Yang Xu, Ulvi Gerst Talas, Alfonso T García-Sosa, Saijaliisa Kangasjärvi, Uko Maran, Maido Remm, M Rob G Roelfsema, Honghong Hu, Jaakko Kangasjärvi, Mart Loog, Julian I Schroeder, Hannes Kollist, Mikael Brosché
Plant gas exchange is regulated by guard cells that form stomatal pores. Stomatal adjustments are crucial for plant survival; they regulate uptake of CO2 for photosynthesis, loss of water, and entrance of air pollutants such as ozone. We mapped ozone hypersensitivity, more open stomata, and stomatal CO2-insensitivity phenotypes of the Arabidopsis thaliana accession Cvi-0 to a single amino acid substitution in MITOGEN-ACTIVATED PROTEIN (MAP) KINASE 12 (MPK12). In parallel, we showed that stomatal CO2-insensitivity phenotypes of a mutant cis (CO2-insensitive) were caused by a deletion of MPK12...
December 2016: PLoS Biology
https://www.readbyqxmd.com/read/27921409/hla-drb-and-hla-dqb-allele-and-haplotype-frequencies-in-iranian-patients-with-recurrent-aphthous-stomatitis
#12
Shamsolmoulouk Najafi, Mahsa Mohammadzadeh, Alireza Zare Bidoki, Ghasem Meighani, Saeed Aslani, Mahdi Mahmoudi, Nima Rezaei
Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles and haplotypes, 54 patients with RAS and 100 unrelated healthy subjects as control group were investigated...
August 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27920889/lack-of-association-between-interleukin-12-gene-polymorphisms-and-recurrent-aphthous-stomatitis
#13
Isaac Firouze Moqadam, Shamsolmoulouk Najafi, Mahsa Mohammadzadeh, Alireza Zare Bidoki, Hila Yousefi, Elham Farhadi, Arghavan Tonekaboni, Ghasem Meighani, Mohsen Mohammadzadeh, Ali Akbar Amirzargar, Nima Rezaei
No abstract text is available yet for this article.
October 2016: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/27920787/interactive-effects-of-elevated-co2-and-water-stress-on-physiological-traits-and-gene-expression-during-vegetative-growth-in-four-durum-wheat-genotypes
#14
Susan Medina, Rubén Vicente, Amaya Amador, José Luis Araus
The interaction of elevated [CO2] and water stress will have an effect on the adaptation of durum wheat to future climate scenarios. For the Mediterranean basin these scenarios include the rising occurrence of water stress during the first part of the crop cycle. In this study, we evaluated the interactive effects of elevated [CO2] and moderate to severe water stress during the first part of the growth cycle on physiological traits and gene expression in four modern durum wheat genotypes. Physiological data showed that elevated [CO2] promoted plant growth but reduced N content...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27920580/positive-clinical-outcomes-derived-from-using-streptococcus-salivarius-k12-to-prevent-streptococcal-pharyngotonsillitis-in-children-a-pilot-investigation
#15
Francesco Di Pierro, Maria Colombo, Alberto Zanvit, Amilcare S Rottoli
BACKGROUND: Streptococcus salivarius K12 (BLIS K12(®)) is a probiotic strain producing the bacteriocins salivaricin A2 and salivaricin B, both of which strongly antagonize the growth of Streptococcus pyogenes, the most important bacterial cause of pharyngeal infections in humans. It successfully colonizes and exhibits persistence in the oral cavity and is endowed with an excellent safety profile. Previous observations of a small group of children indicated that the use of BLIS K12 could also reduce the occurrence of viral pharyngitis...
2016: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/27920509/correlation-between-age-and-gender-in-candida-species-infections-of-complete-denture-wearers-a-retrospective-analysis
#16
Jolanta E Loster, Aneta Wieczorek, Bartłomiej W Loster
AIM: Denture-related stomatitis is a disorder that often affects denture wearers. The purpose of this study was to evaluate the intensity, genera, and frequency of yeasts in the oral cavity of complete denture wearers in terms of subject gender and age. MATERIALS AND METHODS: Nine hundred twenty patients (307 males and 613 females) with complete upper dentures were selected for the study and divided into four age groups: ≤50 years, 51-60, 61-70, and >70 years...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27920181/chikungunya-virus-vaccines-viral-vector-based-approaches
#17
Katrin Ramsauer, Frédéric Tangy
In 2013, a major chikungunya virus (CHIKV) epidemic reached the Americas. In the past 2 years, >1.7 million people have been infected. In light of the current epidemic, with millions of people in North and South America at risk, efforts to rapidly develop effective vaccines have increased. Here, we focus on CHIKV vaccines that use viral-vector technologies. This group of vaccine candidates shares an ability to potently induce humoral and cellular immune responses by use of highly attenuated and safe vaccine backbones...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27919066/designed-proteins-induce-the-formation-of-nanocage-containing-extracellular-vesicles
#18
Jörg Votteler, Cassandra Ogohara, Sue Yi, Yang Hsia, Una Nattermann, David M Belnap, Neil P King, Wesley I Sundquist
Complex biological processes are often performed by self-organizing nanostructures comprising multiple classes of macromolecules, such as ribosomes (proteins and RNA) or enveloped viruses (proteins, nucleic acids and lipids). Approaches have been developed for designing self-assembling structures consisting of either nucleic acids or proteins, but strategies for engineering hybrid biological materials are only beginning to emerge. Here we describe the design of self-assembling protein nanocages that direct their own release from human cells inside small vesicles in a manner that resembles some viruses...
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27918740/inflammatory-papillary-hyperplasia-a-systematic-review
#19
P Gual-Vaqués, E Jané-Salas, S Egido-Moreno, R Ayuso-Montero, A Marí-Roig, J López-López
INTRODUCTION: Inflammatory papillary hyperplasia (IPH) is a benign lesion of the palatal mucosa. It is usually found in denture-wearers but also has been reported in patients without a history of use of a maxillary prosthesis use. OBJECTIVES: The aim of this study is to review the literature to assess the prevalence of denture stomatitis and inflammatory papillary hyperplasia and the etiological factors associated. MATERIAL AND METHODS: A search was carried out in PubMed (January 2005 to October 2015) with the key words "inflammatory papillary hyperplasia", "denture stomatitis", "granular stomatitis" and "Newton's type III" The inclusion criteria were studies including at least a sample of 50 apparently healthy patients, articles published from 2005 to 2015 written in English...
December 6, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27916668/development-of-a-novel-real-time-rt-pcr-assay-to-detect-seneca-valley-virus-1-associated-with-emerging-cases-of-vesicular-disease-in-pigs
#20
Veronica L Fowler, Russell H Ransburgh, Elizabeth G Poulsen, Jemma Wadsworth, Donald P King, Valerie Mioulet, Nick J Knowles, Susanna Williamson, Xuming Liu, Gary A Anderson, Ying Fang, Jianfa Bai
Seneca Valley virus 1 (SVV-1) can cause vesicular disease that is clinically indistinguishable from foot-and-mouth disease, vesicular stomatitis and swine vesicular disease. SVV-1-associated disease has been identified in pigs in several countries, namely USA, Canada, Brazil and China. Diagnostic tests are required to reliably detect this emerging virus, and this report describes the development and evaluation of a novel real-time (r) reverse-transcription (RT) PCR assay (rRT-PCR), targeting the viral polymerase gene (3D) of SVV-1...
January 2017: Journal of Virological Methods
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