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https://www.readbyqxmd.com/read/28527723/activation-of-nrf2-signaling-augments-vesicular-stomatitis-virus-oncolysis-via-autophagy-driven-suppression-of-antiviral-immunity
#1
David Olagnier, Rassin R Lababidi, Samar Bel Hadj, Alexandre Sze, Yiliu Liu, Sharadha Dayalan Naidu, Matteo Ferrari, Yuan Jiang, Cindy Chiang, Vladimir Beljanski, Marie-Line Goulet, Elena V Knatko, Albena T Dinkova-Kostova, John Hiscott, Rongtuan Lin
Oncolytic viruses (OVs) offer a promising therapeutic approach to treat multiple types of cancer. In this study, we show that the manipulation of the antioxidant network via transcription factor Nrf2 augments vesicular stomatitis virus Δ51 (VSVΔ51) replication and sensitizes cancer cells to viral oncolysis. Activation of Nrf2 signaling by the antioxidant compound sulforaphane (SFN) leads to enhanced VSVΔ51 spread in OV-resistant cancer cells and improves the therapeutic outcome in different murine syngeneic and xenograft tumor models...
May 17, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28527334/photo-protective-mechanisms-in-reed-canary-grass-to-alleviate-photo-inhibition-of-psii-on-the-qinghai-tibet-plateau
#2
Chao Zhang, Da-Wei Zhang, Yan-Ni Sun, Muhammad Arfan, Da-Xu Li, Jia-Jun Yan, Ming-Hong You, Shi-Qie Bai, Hong-Hui Lin
Due to its characteristic of high biomass yield potential, there is considerable interest in cultivating Phalaris arundinacea L. cv. 'chuancaoyin No.3' (reed canary grass) on the Qinghai-Tibet Plateau where there is an abundance of alpine steppe meadow and a potential large market for animal husbandry. In this study, we 1) investigate whether reed canary grass exhibits superior productive capacity to Elymus nutans 'Aba' (E. nutans), ordinary common pasture, during the long warm days of summer at high-altitude; and 2) compare the cold tolerance between reed canary grass and E...
May 4, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28526823/stable-stomatal-number-per-minor-vein-length-indicates-the-coordination-between-leaf-water-supply-and-demand-in-three-leguminous-species
#3
Wan-Li Zhao, Zafar Siddiq, Pei-Li Fu, Jiao-Lin Zhang, Kun-Fang Cao
The coordination between minor vein density (MVD) and stomatal density (SD) has been found in many plants. However, we still know little about the influence of leaf node on this correlation relationship. Here, we devised the new functional trait 'stomatal number per minor vein length' (SV). By measuring leaflet area (LA), MVD, SD, and SV, we demonstrated the significance of this functional trait in Arachis hypogaea (peanut) grown under different light regimes and in sun leaves of Dalbergia odorifera and Desmodium renifolium...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28524256/quantification-of-l-carvone-in-toothpastes-available-on-the-swedish-market
#4
Liv Kroona, Gunnar Warfvinge, Marléne Isaksson, Camilla Ahlgren, Jakob Dahlin, Östen Sörensen, Magnus Bruze
BACKGROUND: Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. OBJECTIVES: To qualitatively and quantitatively investigate the presence of l-carvone in commercially available toothpastes on the Swedish market...
May 19, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28520787/development-of-an-r4-dual-site-r4ds-gateway-cloning-system-enabling-the-efficient-simultaneous-cloning-of-two-desired-sets-of-promoters-and-open-reading-frames-in-a-binary-vector-for-plant-research
#5
Mostafa Aboulela, Yuji Tanaka, Kohji Nishimura, Shoji Mano, Mikio Nishimura, Sumie Ishiguro, Tetsuya Kimura, Tsuyoshi Nakagawa
Vast numbers of proteins work cooperatively to exert their functions in various cells. In order to understand the functions and molecular mechanisms of these proteins in plants, analyses of transgenic plants that concomitantly express two protein-coding genes are often required. We developed a novel Gateway cloning technology-compatible binary vector system, the R4 dual-site (R4DS) Gateway cloning system, which enables the easy and efficient cloning of two desired sets of promoters and open reading frames (ORFs) into a binary vector using promoter and ORF entry clones...
2017: PloS One
https://www.readbyqxmd.com/read/28516356/morphology-ultrastructure-and-element-uptake-in-calophyllum-brasiliense-cambess-calophyllaceae-j-agardh-seedlings-under-cadmium-exposure
#6
Alezania Silva Pereira, Priscila Andressa Cortez, Alex-Alan Furtado de Almeida, Majeti Narashima Vara Prasad, Marcel Giovanni Costa França, Maura da Cunha, Raildo Mota de Jesus, Pedro Antônio Oliveira Mangabeira
Cadmium (Cd) is a metal known for its genotoxicity and cytotoxicity, much concerned for its potential environmental and human health impacts. This study evaluates the toxic effect of Cd in Calophyllum brasiliense plants. The plants were cultivated for 30 days in full nutrient solution in order to adapt, and for 15 days in nutrient solution without Cd or with 4, 8, 16, and 32 μmol Cd L(-1). Anatomical analysis of the leaf showed no significant effects of Cd on epidermal thickness in abaxial and adaxial sides, palisade, and spongy parenchyma...
May 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28516287/spread-of-poxviruses-in-livestock-in-brazil-associated-with-cases-of-double-and-triple-infection
#7
Mateus Laguardia-Nascimento, Ana Paula Ferreira de Oliveira, Isabela Ciarlini Azevedo, Anselmo Vasconcelos Rivetti Júnior, Marcelo Fernandes Camargos, Antônio Augusto Fonseca Júnior
The objective of this work is to describe the distribution of outbreaks of vaccinia virus (VACV), pseudocowpox virus (PCPV), and bovine papular stomatitis virus (BSPV) in Brazil. The Official Laboratory of the Brazilian Ministry of Agriculture received 89 samples from different locations in Brazil in 2015 and 2016 for diagnosis of vesicular and exanthematous disease. Poxvirus coinfections occurred in 11 out of 33 outbreaks, including the first reported triple infection by BPSV, PCPV, and VACV. This occurrence may be associated with the circulation of these viruses in Brazilian cattle...
May 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28515881/effect-of-bursaphelenchus-xylophilus-infection-on-leaf-photosynthetic-characteristics-and-resource-use-efficiency-of-pinus-massoniana
#8
Ruihe Gao, Zhuang Wang, Juan Shi, Youqing Luo
Pine wilt disease (PWD) is considered as the most destructive forest-invasive alien species in China. We measured gas exchange parameters and foliar carbon isotope ratios (δ(13)C) of different infection phases of Masson pine in order to investigate the effect of Bursaphelenchus xylophilus infection on photosynthetic responses and resource-use efficiency. The results showed that net photosynthetic rate (Pn), transpiration rate (T), stomatal conductance (gs), and internal CO 2 concentrations (Ci) decreased in the infested trees at photosynthetic photon flux density (PPFD) levels from 0 to 2,000 μmol m(-2) s(-1) compared with controls...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28514874/oncolytic-recombinant-vesicular-stomatitis-virus-vsv-is-nonpathogenic-and-non-transmissible-in-pigs-a-natural-host-of-vsv
#9
Lauro Velazquez-Salinas, Shruthi Naik, Steven Pauszek, Kah-Whye Peng, Stephen J Russell, Luis Rodriguez
Vesicular stomatitis virus (VSV) is a negative-stranded RNA virus that naturally causes disease in livestock including horses, cattle and pigs. The two main identified VSV strains are the New Jersey (VSNJV) and Indiana (VSIV) strains. VSV is a rapidly replicating, potently immunogenic virus that has been engineered to develop novel oncolytic therapies for cancer treatment. Swine are a natural host for VSV and provide a relevant and well-established model, amenable to biological sampling to monitor virus shedding and neutralizing antibodies...
May 17, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28514243/celiac-disease-symptom-resolution-effectiveness-of-the-gluten-free-diet
#10
Naire Sansotta, Stefano Guandalini, Karine Amirikian, Hilary Jericho
OBJECTIVE: To evaluate the efficacy of the gluten free diet (GFD) on gastrointestinal and extra-intestinal symptom resolution and identify predictors for persistence of symptoms in all celiac patients at the University of Chicago. METHODS: We conducted a retrospective chart review from 2002 to 2015. Gastrointestinal (GI) symptoms included: abdominal pain, bloating, constipation, diarrhea, failure to thrive/weight loss, nausea, reflux and vomiting. Extra-intestinal (EI) symptoms included: abnormal liver enzymes, arthralgia/arthritis, dermatitis herpetiformis, alopecia, fatigue, headache, anemia, stomatitis, myalgia, psychiatric disorders, rashes, seizures, neuropathy, short stature, delayed puberty, osteoporosis, and infertility...
May 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28513913/determination-of-role-of-ceruloplasmin-in-oral-potentially-malignant-disorders-and-oral-malignancy-a-cross-sectional-study
#11
Palak H Shah, Rashmi Venkatesh, Chandramani B More
OBJECTIVES: In the process of carcinogenesis, lipid peroxidation and increased oxidative stress leads to changes in certain antioxidants. The present study was aimed to assess and co-relate serum levels of ceruloplasmin in oral premalignancies and oral cancer so as to gauge its possible association with the process of carcinogenesis and to determine its role as tumor marker. MATERIAL AND METHODS: The total of 300 participants, were equally divided in six study groups i...
May 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28512604/traditional-dentistry-knowledge-among-serbs-in-several-balkan-countries
#12
Dragan V Ilic, Biljana Andjelski Radicevic, Anely Nedelcheva, Ivana Djurovic, Dejan Ostojic
BACKGROUND/AIM: There are still unrevealed treasures of traditional dental medicine, that is, the reason to investigate and present various ways in treatment of oral and orofacial tissues, as well as magic and religious elements involved in representative areas among Serbs. MATERIALS AND METHODS: Information was collected from the elderly non-professional folk dentists and herbalists with the additional help of local physicians and dentists that was done through questionnaire and personal interviews...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28512466/salinity-stress-does-not-affect-root-uptake-dissemination-and-persistence-of-salmonella-in-sweet-basil-ocimum-basilicum
#13
Nirit Bernstein, Shlomo Sela Saldinger, Nativ Dudai, Elena Gorbatsevich
Crop produce can be contaminated in the field during cultivation by bacterial human pathogens originating from contaminated soil or irrigation water. The bacterial pathogens interact with the plant, can penetrate the plant via the root system and translocate and survive in above-ground tissues. The present study is first to investigate effects of an abiotic stress, salinity, on the interaction of plants with a bacterial human pathogen. The main sources of human bacterial contamination of plants are manures and marginal irrigation waters such as treated or un-treated wastewater...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28511497/assessment-of-oxidant-antioxidant-status-and-stress-factor-in-recurrent-aphthous-stomatitis-patients-case-control-study
#14
Sherin Ziaudeen, Rathy Ravindran
INTRODUCTION: Despite its vast occurrence, the aetiology of Recurrent Aphthous Stomatitis (RAS) still remains unknown and its aetiology is multifactorial. The factors believed to be associated with the aetiology of RAS, may disturb the equilibrium of oxidant-antioxidant status of the organism and may accelerate the formation of free radicals, resulting in Oxidative Stress (OS). Psychological stress is believed to act as a triggering factor or modifying factor for RAS. AIM: To find whether oxidant-antioxidant status and psychosocial stress play a role in the pathogenesis of RAS...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511115/apoplastic-ros-signaling-in-plant-immunity
#15
REVIEW
Junsheng Qi, Jinlong Wang, Zhizhong Gong, Jian-Min Zhou
Reactive oxygen species (ROS) are widely produced in different cellular compartments under both biotic and abiotic stress conditions. ROS play a central role in plant signaling and regulate diverse cellular processes. Recent advances are shedding new light on sophisticated mechanisms controlling ROS biogenesis and signaling in plant immunity. In this review, we summarize our current understanding of the regulation of apoplastic ROS production in response to microbial molecular patterns and draw comparison with abscisic acid (ABA)-induced apoplastic ROS...
May 13, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28507556/differential-effects-of-phosphatidylinositol-4-kinase-pi4k-and-3-kinase-pi3k-inhibitors-on-stomatal-responses-to-environmental-signals
#16
Sho Takahashi, Keina Monda, Takumi Higaki, Mimi Hashimoto-Sugimoto, Juntaro Negi, Seiichiro Hasezawa, Koh Iba
Specific cellular components including products of phosphatidylinositol (PI) metabolism play an important role as signaling molecules in stomatal responses to environmental signals. In this study, pharmacological inhibitors of a set of cellular components, including PI4-kinase (PI4K) and PI3K, were used to investigate stomatal closure in response to CO2, darkness, and abscisic acid (ABA). Treatment with PAO, a specific inhibitor of PI4K, specifically inhibited the stomatal response to CO2 compared with that to darkness and ABA...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28507175/a-mutation-in-the-bhlh-domain-of-the-spch-transcription-factor-uncovers-a-br-dependent-mechanism-for-stomatal-development
#17
Alberto de Marcos, Anaxi Houbaert, Magdalena Triviño, Dolores Delgado, Mar Martín-Trillo, Eugenia Russinova, Carmen Fenoll, Montaña Mena
The asymmetric cell divisions necessary for stomatal lineage initiation and progression in Arabidopsis thaliana require the function of the basic helix-loop-helix (bHLH) transcription factor SPEECHLESS (SPCH). Mutants lacking SPCH do not produce stomata or lineages. Here, we isolated a new spch 5 allele carrying a point mutation in the bHLH domain that displayed normal growth, but had an extremely low number of sometimes clustered stomata in the leaves, whereas the hypocotyls were stomataless. In vivo tracking of leaf epidermal cell divisions, combined with marker lines and genetic analysis, showed that the spch 5 leaf phenotype is dosage dependent and results from the decreased ability to initiate and amplify lineages, defects in asymmetric cell fate allocation, and misorientation of asymmetric division planes...
May 15, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28503186/the-pepper-ring-finger-e3-ligase-cadir1-regulates-the-drought-stress-response-via-aba-mediated-signaling
#18
Hyunhee Joo, Chae Woo Lim, Sang-Wook Han, Sung Chul Lee
Drought stress from soil or air limits plant growth and development, leading to a reduction in crop productivity. Several E3 ligases positively or negatively regulate the drought stress response. In the present study, we show that the pepper (Capsicum annuum) Drought Induced RING type E3 ligase 1, CaDIR1, regulates the drought stress response via abscisic acid (ABA)-mediated signaling. CaDIR1 contains a C3HC4-type RING finger domain in the N-terminal region; this domain functions during protein degradation via attachment of ubiquitins to the substrate target proteins...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28497627/allergic-contact-stomatitis-caused-by-neem-leaves-azadirachta-indica
#19
Betsy Ambooken, Sarin Abdulsalam, Neelakandhan Asokan, Anita Abraham
No abstract text is available yet for this article.
June 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28496016/effects-of-a-rebamipide-mouthwash-on-stomatitis-caused-by-cancer-chemotherapy-evaluation-of-the-efficacy-by-patients-themselves
#20
Naoko Ishii, Yayoi Kawano, Hideki Sakai, Seitaku Hayashi, Norikazu Akiduki, Masayo Komoda, Takehisa Hanawa
  Anticancer drug-induced stomatitis develops in 30% to 40% of cancer cases that undergo chemotherapy. However, medications for this condition are not commercially available in Japan. Upon obtaining approval of the ethics committee, a mouthwash containing rebamipide as the active ingredient (rebamipide mouthwash) was administered to one inpatient and four outpatients, who had developed stomatitis caused by cancer chemotherapy. Starting from 14 days after the administration of the rebamipide mouthwash, the patients scored a stomatitis survey on oral state, pain level, and diet and recorded the number of times they gargled, as well as any stomatitis observations, in a stomatitis diary...
May 11, 2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
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