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https://www.readbyqxmd.com/read/28345122/effect-of-laser-on-pain-relief-and-wound-healing-of-recurrent-aphthous-stomatitis-a-systematic-review
#1
REVIEW
Valerie G A Suter, Sophia Sjölund, Michael M Bornstein
The aim of this systematic review was to assess a potential benefit of laser use in the treatment of recurrent aphthous stomatitis (RAS). The primary outcome variables were pain relief, duration of wound healing and reduction in episode frequency. A PICO approach was used as a search strategy in Medline, Embase and Cochrane databases. After scanning and excluding titles, abstracts and full texts, 11 studies (ten RCTs and one non-randomised controlled trial) were included. Study selection and data extraction was done by two observers...
March 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28344996/codon-optimization-leads-to-functional-impairment-of-rd114-tr-envelope-glycoprotein
#2
Eleonora Zucchelli, Monika Pema, Anna Stornaiuolo, Claudia Piovan, Cinzia Scavullo, Erica Giuliani, Sergio Bossi, Stefano Corna, Claudia Asperti, Claudio Bordignon, Gian-Paolo Rizzardi, Chiara Bovolenta
Lentiviral vectors (LVs) are a highly valuable tool for gene transfer currently exploited in basic, applied, and clinical studies. Their optimization is therefore very important for the field of vectorology and gene therapy. A key molecule for LV function is the envelope because it guides cell entry. The most commonly used in transiently produced LVs is the vesicular stomatitis virus glycoprotein (VSV-G) envelope, whose continuous expression is, however, toxic for stable LV producer cells. In contrast, the feline endogenous retroviral RD114-TR envelope is suitable for stable LV manufacturing, being well tolerated by producer cells under constitutive expression...
March 17, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28344409/outbreak-of-foot-and-mouth-disease-and-peste-des-petits-ruminants-in-sheep-flock-imported-for-immediate-slaughter-in-riyadh
#3
M A Mahmoud, S A Galbat
AIM: To detect and identify the causative agent or agents of the following clinical symptoms which were fever, lack of appetite, salivation, vesiculation, erosions of the buccal mucosa, nose, and feet. The signs vary from mild to severe. The mortality rate of the disease is high. The morbidity rate reaches up to 100%. Sheep also show bloody diarrhea and rapid respiration. Sheep flock resident in El-Kharje Governorate. MATERIALS AND METHODS: A total of 50 serum samples and 50 buffy coat samples were collected from Marino sheep flock suffered from high mortalities, fever, lameness, diarrhea, stomatitis, and respiratory distress...
February 2017: Veterinary World
https://www.readbyqxmd.com/read/28343845/curcumin-inhibits-zika-and-chikungunya-virus-infection-by-inhibiting-cell-binding
#4
Bryan C Mounce, Teresa Cesaro, Lucia Carrau, Thomas Vallet, Marco Vignuzzi
Several compounds extracted from spices and herbs exhibit antiviral effects in vitro, suggesting potential pharmacological uses. Curcumin, a component of turmeric, has been used as a food additive and herbal supplement due to its potential medicinal properties. Previously, curcumin exhibited antiviral properties against several viruses, including dengue virus and hepatitis C virus, among others. Here, we describe the antiviral effect of curcumin on Zika and chikungunya viruses, two mosquito-borne outbreak viruses...
March 23, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28343210/periodic-fever-aphthous-stomatitis-pharyngitis-and-cervical-adenitis-pfapa-syndrome-in-children
#5
Vira B Semianchuk
INTRODUCTION: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome refers to a group of primary immunodeficiencies, namely autoinflammatory diseases. Most pediatricians and otolaryngologists do not suspect PFAPA syndrome when treating recurrent pharyngitis (according to Ukrainian classification - tonsillitis) and stomatitis. Therefore, patients with a given syndrome receive unnecessary treatment (antibiotic therapy or antiviral drugs) and the diagnosis is made late...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28342210/does-the-turgor-loss-point-characterise-drought-response-in-dryland-plants
#6
Claire Farrell, Christopher Szota, Stefan K Arndt
The water potential at turgor loss point (Ψtlp ) has been suggested as a key functional trait for determining plant drought tolerance, due to its close relationship with stomatal closure. Ψtlp may indicate drought tolerance as plants which maintain gas exchange at lower midday water potentials as soil water availability declines also have lower Ψtlp . We evaluated 17 species from seasonally dry habitats, representing a range of life-forms, under well-watered and drought conditions, to determine how Ψtlp relates to stomatal sensitivity (pre-dawn water potential at stomatal closure: Ψgs0 ) and drought strategy (degree of isohydry or anisohydry; ΔΨMD between WW conditions and stomatal closure)...
March 24, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28342111/ckb1-is-involved-in-abscisic-acid-and-gibberellic-acid-signaling-to-regulate-stress-responses-in-arabidopsis-thaliana
#7
Congying Yuan, Jianping Ai, Hongping Chang, Wenjun Xiao, Lu Liu, Cheng Zhang, Zhuang He, Ji Huang, Jinyan Li, Xinhong Guo
Casein kinase II (CK2), an evolutionarily well-conserved Ser/Thr kinase, plays critical roles in all higher organisms including plants. CKB1 is a regulatory subunit beta of CK2. In this study, homozygous T-DNA mutants (ckb1-1 and ckb1-2) and over-expression plants (35S:CKB1-1, 35S:CKB1-2) of Arabidopsis thaliana were studied to understand the role of CKB1 in abiotic stress and gibberellic acid (GA) signaling. Histochemical staining showed that although CKB1 was expressed in all organs, it had a relatively higher expression in conducting tissues...
March 24, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28341957/phase-ib-dose-finding-trial-of-lapatinib-plus-pegylated-liposomal-doxorubicin-in-advanced-her2-positive-breast-cancer
#8
Andrea Rocca, Lorenzo Cecconetto, Alessandro Passardi, Elisabetta Melegari, Daniele Andreis, Manuela Monti, Roberta Maltoni, Samanta Sarti, Elisabetta Pietri, Alessio Schirone, Francesco Fabbri, Caterina Donati, Oriana Nanni, Anna Fedeli, Marina Faedi, Dino Amadori
PURPOSE: Combination of anthracyclines with trastuzumab is hampered by cardiotoxicity. Pegylated liposomal doxorubicin and lapatinib could represent a safer alternative to combination therapy. METHODS: In this phase Ib study with 3 + 3 dose escalation design, patients with HER2-positive advanced breast cancer received pegylated liposomal doxorubicin 30 mg/m(2) intravenously on day 1 plus lapatinib 1250 (level 1) or 1500 (level 2) mg/day orally on days 1-21 of each 21-day cycle...
March 24, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28341769/stomatal-defense-a-decade-later
#9
Maeli Melotto, Li Zhang, Paula Rodrigues Oblessuc, Sheng Yang He
No abstract text is available yet for this article.
March 24, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28339719/the-pepper-wpp-domain-protein-cawdp1-acts-as-a-novel-negative-regulator-of-drought-stress-via-aba-signaling
#10
Chanmi Park, Chae Woo Lim, Woonhee Baek, Jung-Hyun Kim, Sohee Lim, Sang Hyon Kim, Kyung-Nam Kim, Sung Chul Lee
Plants are constantly challenged by various environmental stresses, including high salinity and drought, and they have evolved defense mechanisms to counteract the deleterious effects of these stresses. The plant hormone abscisic acid (ABA) regulates plant growth and developmental processes and mediates abiotic stress responses. Here, we report the identification and characterization of a novel CaWDP1 (Capsicum annuumWPP Domain Protein 1) protein. The expression of CaWDP1 in pepper leaves was induced by ABA, drought, and NaCl treatments, suggesting its role in the abiotic stress response...
February 22, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28338978/isotope-signals-and-anatomical-features-in-tree-rings-suggest-a-role-for-hydraulic-strategies-in-diffuse-drought-induced-die-back-of-pinus-nigra
#11
Laura Petrucco, Andrea Nardini, Georg von Arx, Matthias Saurer, Paolo Cherubini
The 2003 and 2012 summer seasons were among the warmest and driest of the last 200 years over southeastern Europe, and in particular in the Karst region (northeastern Italy). Starting from winter-spring 2013, several black pines (Pinus nigra J.F. Arnold) suffered crown die-back. Declining trees occurred nearby individuals with no signs of die-back, raising hypotheses about the occurrence of individual-specific hydraulic strategies underlying different responses to extreme drought. We investigated possible processes driving black pine decline by dendrochronological and wood anatomical measurements, coupled with analysis of tree-ring carbon (δ13C) and oxygen (δ18O) isotopic composition in healthy trees (H) and trees suffering die-back (D)...
March 17, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338959/increase-in-leaf-temperature-opens-stomata-and-decouples-net-photosynthesis-from-stomatal-conductance-in-pinus-taeda-and-populus-deltoides-x-nigra
#12
Josef Urban, Miles W Ingwers, Mary Anne McGuire, Robert O Teskey
The effect of temperature on stomatal conductance (gs) and corresponding gas exchange parameters was studied in two tree species with contrasting leaf anatomy and ecophysiology-a broadleaf angiosperm, Populus deltoides x nigra (poplar), and a needle-leaf gymnosperm, Pinus taeda (loblolly pine). Experiments were conducted in growth chambers across a leaf temperature range of 19-48°C. Manipulations of temperature were done in well-watered and drought soil conditions and under ambient (400 ppm) and elevated (800 ppm) air CO2 concentrations...
March 6, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28338952/physiological-and-morphological-responses-to-permanent-and-intermittent-waterlogging-in-seedlings-of-four-evergreen-trees-of-temperate-swamp-forests
#13
Alejandra Zúñiga-Feest, Angela Bustos-Salazar, Fernanda Alves, Vanessa Martinez, Cecilia Smith-Ramírez, Joào Pereira
Waterlogging decreases a plant's metabolism, stomatal conductance (gs) and photosynthetic rate (A); however, some evergreen species show acclimation to waterlogging. By studying both the physiological and morphological responses to waterlogging, the objective of this study was to assess the acclimation capacity of four swamp forest species that reside in different microhabitats. We proposed that species (Luma apiculata [D.C.] Burret. and Drimys winteri J.R. et G. Forster.) abundant in seasonally and intermittently waterlogged areas (SIWA) would have a higher acclimation capacity than species abundant in the inner swamp (Blepharocalyx cruckshanksii [H et A...
March 14, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338895/photosynthesis-nutrient-accumulation-and-growth-of-two-betula-species-exposed-to-waterlogging-in-late-dormancy-and-in-the-early-growing-season
#14
Ai-Fang Wang, Marja Roitto, Tarja Lehto, Sirkka Sutinen, Jaakko Heinonen, Gang Zhang, Tapani Repo, Ram Oren
Increased risk of soil waterlogging in winter and spring at northern latitudes will potentially affect forest production in the future. We studied gas exchange, chlorophyll content index, chlorophyll fluorescence, nutrient concentration and biomass accumulation in 1-year-old silver (Betula pendula Roth) and pubescent birch (Betula pubescens Ehrh.) seedlings. We hypothesized that B. pubescens has different physiological mechanisms that make it tolerate waterlogging better than B. pendula. The treatments were: (i) no waterlogging throughout the experiment; (ii) 4-week waterlogging during dormancy (dormancy waterlogging 'DW'); (iii) 4-week waterlogging during the early growing season (growth waterlogging 'GW'); and (iv) 4-week DW followed by 4-week GW during the early growing season ('DWGW')...
March 15, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338833/a-humidity-shock-leads-to-rapid-temperature-dependent-changes-in-coffee-leaf-physiology-and-gene-expression
#15
El-Hadji Thioune, James McCarthy, Thomas Gallagher, Bruce Osborne
Climate change is expected to increase the frequency of above-normal atmospheric water deficits contemporaneous with periods of high temperatures. Here we explore alterations in physiology and gene expression in leaves of Coffea canephora Pierre ex A. Froehner caused by a sharp drop in relative humidity (RH) at three different temperatures. Both stomatal conductance (gs) and CO2 assimilation (A) measurements showed that gs and A values fell quickly at all temperatures after the transfer to low RH.  However, leaf relative water content measurements indicated that leaves nonetheless experienced substantial water losses, implying that stomatal closure and/or resupply of water was not fast enough to stop excessive evaporative losses...
February 8, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338800/a-steady-state-stomatal-model-of-balanced-leaf-gas-exchange-hydraulics-and-maximal-source-sink-flux
#16
Teemu Hölttä, Anna Lintunen, Tommy Chan, Annikki Mäkelä, Eero Nikinmaa
Trees must simultaneously balance their CO2 uptake rate via stomata, photosynthesis, the transport rate of sugars and rate of sugar utilization in sinks while maintaining a favourable water and carbon balance. We demonstrate using a numerical model that it is possible to understand stomatal functioning from the viewpoint of maximizing the simultaneous photosynthetic production, phloem transport and sink sugar utilization rate under the limitation that the transpiration-driven hydrostatic pressure gradient sets for those processes...
February 23, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338736/microcompartmentation-of-cytosolic-aldolase-by-interaction-with-the-actin-cytoskeleton-in-arabidopsis
#17
Constantine Garagounis, Kalliopi-Ioanna Kostaki, Tim J Hawkins, Ian Cummins, Mark D Fricker, Patrick J Hussey, Alistair M Hetherington, Lee J Sweetlove
Evidence is accumulating for molecular microcompartments formed when proteins interact in localized domains with the cytoskeleton, organelle surfaces, and intracellular membranes. To understand the potential functional significance of protein microcompartmentation in plants, we studied the interaction of the glycolytic enzyme fructose bisphosphate aldolase with actin in Arabidopsis thaliana. Homology modelling of a major cytosolic isozyme of aldolase, FBA8, suggested that the tetrameric holoenzyme has two actin binding sites and could therefore act as an actin-bundling protein, as was reported for animal aldolases...
February 17, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28335205/photosensitizer-embedded-polyacrylonitrile-nanofibers-as-antimicrobial-non-woven-textile
#18
Sarah L Stanley, Frank Scholle, Jiadeng Zhu, Yao Lu, Xiangwu Zhang, Xingci Situ, Reza A Ghiladi
Toward the objective of developing platform technologies for anti-infective materials based upon photodynamic inactivation, we employed electrospinning to prepare a non-woven textile comprised of polyacrylonitrile nanofibers embedded with a porphyrin-based cationic photosensitizer; termed PAN-Por((+)). Photosensitizer loading was determined to be 34.8 nmol/mg material; with thermostability to 300 °C. Antibacterial efficacy was evaluated against four bacteria belonging to the ESKAPE family of pathogens (Staphylococcus aureus; vancomycin-resistant Enterococcus faecium; Acinetobacter baumannii; and Klebsiella pneumonia), as well as Escherichia coli...
April 20, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334974/efficacy-and-safety-of-sequential-use-of-everolimus-in-japanese-patients-with-advanced-renal-cell-carcinoma-after-failure-of-first-line-treatment-with-vascular-endothelial-growth-factor-receptor-tyrosine-kinase-inhibitor-a-multicenter-phase-ii-clinical-trial
#19
Masafumi Oyama, Takayuki Sugiyama, Masahiro Nozawa, Kiyohide Fujimoto, Takeshi Kishida, Go Kimura, Noriaki Tokuda, Shiro Hinotsu, Kojiro Shimozuma, Hideyuki Akaza, Seiichiro Ozono
Objective: Many studies have shown the efficacy of everolimus after pretreatment with vascular endothelial growth factor receptor-tyrosine kinase inhibitors. We investigated the efficacy and safety of everolimus as a second-line treatment after the failure of vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapy in Japanese patients with advanced renal cell carcinoma. Methods: This was an open-label, multicenter, phase II trial conducted in Japan through the central registration system...
March 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28331003/phase-i-dose-escalation-study-of-taselisib-gdc-0032-an-oral-pi3k-inhibitor-in-patients-with-advanced-solid-tumors
#20
Dejan Juric, Ian Krop, Ramesh K Ramanathan, Timothy R Wilson, Joseph A Ware, Sandra Sanabria Bohorquez, Heidi Savage, Deepak Sampath, Laurent Salphati, Ray Lin, Huan Jin, Hema Parmar, Jerry Y Hsu, Daniel D Von Hoff, José Baselga
Taselisib is a potent and selective tumor growth inhibitor through PI3K pathway suppression. Thirty-four patients with locally advanced or metastatic solid tumors were treated (phase I study, modified 3+3 dose escalation; 5 cohorts; 3-16 mg taselisib once daily capsule). Taselisib pharmacokinetics were dose-proportional; mean half-life was 40 hours. Frequent dose-dependent, treatment-related adverse events included diarrhea, hyperglycemia, decreased appetite, nausea, rash, stomatitis, and vomiting. At 12 and 16 mg dose levels, dose limiting toxicities (DLT) were observed, with an accumulation of higher-grade adverse events after the cycle 1 DLT assessment window...
March 22, 2017: Cancer Discovery
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