Ana P Peredo, Sarah E Gullbrand, Chet S Friday, Brianna S Orozco, Bijan Dehghani, Austin C Jenk, Edward D Bonnevie, Rachel L Hilliard, Hannah M Zlotnick, George R Dodge, Daeyeon Lee, Julie B Engiles, Michael W Hast, Thomas P Schaer, Harvey E Smith, Robert L Mauck
Conventional microdiscectomy treatment for intervertebral disc herniation alleviates pain but does not repair the annulus fibrosus, resulting in a high incidence of recurrent herniation and persistent dysfunction. The lack of repair and the acute inflammation that arise after injury can further compromise the disc and result in disc-wide degeneration in the long term. To address this clinical need, we developed tension-activated repair patches (TARPs) for annulus fibrosus repair and local delivery of the anti-inflammatory factor anakinra (a recombinant interleukin-1 receptor antagonist)...
November 15, 2023: Science Translational Medicine