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https://www.readbyqxmd.com/read/29474996/considerations-for-exercise-prescription-in-patients-with-bone-metastases-a-comprehensive-narrative-review
#1
REVIEW
Gráinne Sheill, Emer M Guinan, Nicola Peat, Juliette Hussey
Metastatic disease is a frequent complication of advanced cancer, with bone representing one of the most common sites of metastatic occurrence. Patients with bone metastases receive long-term systemic treatments which have a significant attritional impact on muscle strength, fatigue and physical functioning. Physical rehabilitation involving exercise and physical activity prescription has a considerable role in counteracting these changes however exercise is often perceived as a contraindication in the presence of bone metastases due to concerns about aggravating skeletal related events...
February 20, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29473968/safety-and-oncologic-outcomes-of-robotic-liver-resections-a-systematic-review
#2
REVIEW
Diamantis I Tsilimigras, Dimitrios Moris, Stylianos Vagios, Katiuscha Merath, Timothy M Pawlik
The robotic system has emerged as a new minimally invasive technology with promising results. We sought to systematically review the available literature on the safety and the oncologic outcomes of robotic liver surgery. A systematic review was conducted using Medline (PubMed), Embase and Cochrane library through November 12th, 2017. A robotic approach may be a safe and feasible surgical option for minor and major liver resections.
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473967/importance-of-wide-re-resection-in-adult-spermatic-cord-sarcomas-report-on-oncologic-outcomes-at-a-single-institution
#3
Katie S Murray, Emily A Vertosick, Massimiliano Spaliviero, Joseph W Mashni, Daniel D Sjoberg, Kaled M Alektiar, Harry W Herr, Paul Russo, Jonathan A Coleman
BACKGROUND AND OBJECTIVES: We evaluated the effect of re-resection with wide margins (undertaken because initial resection performed elsewhere was incomplete) on survival in patients with spermatic cord sarcoma (SCS). METHODS: After excluding those with metastatic disease and those not undergoing surgical intervention, the records of 72 consecutive patients treated for SCS between 1981 and 2011 at Memorial Sloan Kettering Cancer Center were reviewed. Recurrence-free survival (RFS) and cancer-specific survival were calculated using the Kaplan-Meier method for comparing between the 48 patients who underwent wide re-resection (WRR) within 5 months of diagnosis and the 24 who did not...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473959/reconstruction-using-a-constrained-type-hip-tumor-prosthesis-after-resection-of-malignant-periacetabular-tumors-a-study-by-the-japanese-musculoskeletal-oncology-group-jmog
#4
Koichi Ogura, Michiro Susa, Hideo Morioka, Akihiko Matsumine, Takeshi Ishii, Kenichiro Hamada, Takafumi Ueda, Akira Kawai
BACKGROUND: We conducted a nationwide survey of prosthetic reconstruction using a constrained-type hip tumor prosthesis (C-THA) following resection of periacetabular tumors. METHODS: Eighty patients with periacetabular tumors underwent wide resection and prosthetic reconstruction using C-THA at JMOG-affiliated institutions (39 males and 41 females; mean age, 46.7 years; mean follow-up period, 65 months). Primary bone or soft tissue sarcoma accounted for 75% of the cases...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473334/treatment-related-mortality-in-newly-diagnosed-pediatric-cancer-a-population-based-analysis
#5
Paul Gibson, Jason D Pole, Tanya Lazor, Donna Johnston, Carol Portwine, Mariana Silva, Sarah Alexander, Lillian Sung
Using a previously developed reliable and valid treatment-related mortality (TRM) definition, our objective was to describe the proportion of children newly diagnosed with cancer experiencing TRM and to identify risk factors for TRM in a population-based cohort. We included children with cancer <19 years diagnosed and treated in Ontario who were diagnosed between 2003 and 2012. Children with cancer were identified using data in a provincial registry. Cumulative incidence of TRM was calculated where progressive disease death was considered a competing event...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29472723/flow-cytometric-vs-morphologic-assessment-of-remission-in-childhood-acute-lymphoblastic-leukemia-a-report-from-the-children-s-oncology-group-cog
#6
Sumit Gupta, Meenakshi Devidas, Mignon L Loh, Elizabeth A Raetz, Si Chen, Cindy Wang, Patrick Brown, Andrew J Carroll, Nyla A Heerema, Julie M Gastier-Foster, Kimberly P Dunsmore, Eric C Larsen, Kelly W Maloney, Leonard A Mattano, Stuart S Winter, Naomi J Winick, William L Carroll, Stephen P Hunger, Michael J Borowitz, Brent L Wood
Minimal residual disease (MRD) after initial therapy is integral to risk stratification in B-precursor and T-precursor acute lymphoblastic leukemia (B-ALL, T-ALL). Although MRD determines depth of remission, remission remains defined by morphology. We determined the outcomes of children with discordant assessments of remission by morphology vs. flow cytometry using patients age 1-30.99 years enrolled on Children's Oncology Group ALL trials who underwent bone marrow assessment at the end of induction (N = 9350)...
February 23, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29472106/open-versus-laparoscopic-portal-lymphadenectomy-in-gallbladder-cancer-is-there-a-difference-in-lymph-node-yield
#7
Cecilia T Ong, Kenneth Leung, Daniel P Nussbaum, Zhifei Sun, Beat Gloor, Dan G Blazer, Mathias Worni
BACKGROUND: Gallbladder cancer (GBC) is the most common biliary tract malignancy. Because it commonly metastasizes via lymphatics, portal lymphadenectomy should be included in oncologic resections. This study aimed to compare the oncologic equivalence of the laparoscopic versus open technique by evaluating lymph node (LN) yield. METHODS: The 2010-2012 National Cancer Data Base identified patients who underwent laparoscopic or open resection of GBC with dedicated lymphadenectomy...
February 19, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29472064/major-postoperative-complications-compromise-oncological-outcomes-of-patients-with-intrahepatic-cholangiocarcinoma-after-curative-resection-a-13-year-cohort-in-a-tertiary-center
#8
Ka Wing Ma, Tan To Cheung, Wong Hoi She, Kenneth Siu Ho Chok, Albert Chi Yan Chan, Wing Chiu Dai, Simon Hin Yin Tsang, Chung Mau Lo
BACKGROUND/OBJECTIVE: Hepatectomy is the mainstay of curative treatment for intrahepatic cholangiocarcinoma (ICC). The relationship between postoperative complication and oncological outcome has not been defined. We aimed to elucidate the effect of postoperative complication on long-term survival of ICC patients after curative resection. METHODS: Data of consecutive patients who had curative resection for ICC at our hospital from 1991 to 2013 were reviewed. Patients with cholangiohepatocellular carcinoma, metastatic adenocarcinoma or Klaskin tumor were excluded...
February 19, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29471614/surgical-steps-for-standard-laparoscopic-low-anterior-resection
#9
Sophie K Allen, Kat E Schwab, Timothy A Rockall
Once considered an incurable disease, the continuous evolution of technologies and techniques has improved both oncological outcomes and quality of life for patients with rectal cancer. Multiport laparoscopic surgery for rectal cancer is the standard of care in many institutions and countries and is the approach that has been most subjected to controlled trial. Following a number of randomized trials as well as large series and registry reports and several Cochrane reviews there is no evidence of any oncological disadvantage to laparoscopic surgery compared to the open approach and there is good evidence of improved short-term outcomes and some evidence of improved long-term outcomes...
February 21, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29468476/current-treatment-of-pediatric-bladder-and-prostate-rhabdomyosarcoma
#10
REVIEW
Amanda F Saltzman, Nicholas G Cost
PURPOSE OF REVIEW: Rhabdomyosarcoma (RMS) is the most common sarcoma diagnosed in the first 20 years of life; bladder/prostate (BP) RMS accounts for 5% of all cases. Through efforts from multiple cooperative study groups, survival has improved significantly. This article aims to review the complex RMS classification system and treatment of BP RMS, with a focus on developing aspects of treatment. RECENT FINDINGS: Recent advancements in technology are responsible for most of the progress in RMS treatment...
February 22, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29468352/local-excision-for-ypt2-rectal-cancer-following-preoperative-chemoradiation-therapy-it-should-not-be-justified
#11
Kwan Mo Yang, Seok-Byung Lim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Chang Sik Yu, Jin Cheon Kim
PURPOSE: Among individuals who respond well to preoperative chemoradiation therapy (CRT) for ypT0-1, local excision (LE) could provide acceptable oncological outcomes. However, in ypT2 cases, the oncological safety of LE has not been determined. This study aimed to compare oncological outcomes between LE and total mesorectal excision of ypT2-stage rectal cancer after chemoradiation therapy and investigate the oncological safety of LE in these patients. METHODS: We included 351 patients who exhibited ypT2-stage rectal cancer after CRT followed by LE (n = 16 [5%]) or total mesorectal excision (TME) (n = 335 [95%]) after preoperative CRT between January 2007 and December 2013...
February 21, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29467913/oncoplastic-reduction-pattern-technique-following-removal-of-giant-fibroadenoma
#12
Andrea Hiller, Thomas J Lee, Joshua Henderson, Nicolas Ajkay, Bradon J Wilhelmi
Objective: Oncoplastic surgery was developed to allow for large tumor excision and immediate breast reconstruction with the goal of optimal breast shape and symmetry. Although initially used in women who underwent lumpectomy for breast malignancy, these techniques can be useful for cosmetic issues caused by benign breast disease. We describe a modification of an inferior pedicle with Wise-pattern reduction mammoplasty for oncoplastic reconstruction of a giant fibroadenoma. Methods: A 30-year-old woman with size 32 DD breasts was referred by the surgical oncologist with a biopsy-proven fibroadenoma of the right breast...
2018: Eplasty
https://www.readbyqxmd.com/read/29467881/diffuse-large-b-cell-lymphoma-10-years-real-world-clinical-experience-with-rituximab-plus-cyclophosphamide-doxorubicin-vincristine-and-prednisolone
#13
Matej Horvat, Vesna Zadnik, Tanja Južnič Šetina, Lučka Boltežar, Jana Pahole Goličnik, Srdjan Novaković, Barbara Jezeršek Novaković
Treatment with rituximab plus a regimen of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) for patients with diffuse large B-cell lymphoma (DLBCL) has proven efficacy in clinical trials. The present study investigated its application in clinical practice. This single-center, retrospective database analysis included patients with DLBCL treated at the Slovenian Institute of Oncology Ljubljana between 2004 and 2013. Overall survival (OS) and progression-free survival (PFS) were assessed according to International Prognostic Index (IPI) and revised IPI (R-IPI) categories...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467138/-pathways-patient-centred-decision-counselling-for-women-at-risk-of-cancer-related-infertility-a-protocol-for-a-comparative-effectiveness-cluster-randomised-trial
#14
Terri Lynn Woodard, Aubri S Hoffman, Laura C Crocker, Deborah A Holman, Derek B Hoffman, Jusheng Ma, Roland L Bassett, Viola B Leal, Robert J Volk
INTRODUCTION: National guidelines recommend that all reproductive-age women with cancer be informed of their fertility risks and offered referral to fertility specialists to discuss fertility preservation options. However, reports indicate that only 5% of patients have consultations, and rates of long-term infertility-related distress remain high. Previous studies report several barriers to fertility preservation; however, initial success has been reported using provider education, patient decision aids and navigation support...
February 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29466966/real-life-patterns-of-care-and-progression-free-survival-in-metastatic-renal-cell-carcinoma-patients-retrospective-analysis-of-cross-sectional-data
#15
Rana Maroun, Laura Mitrofan, Laure Benjamin, Gaelle Nachbaur, Franck Maunoury, Philippe Le Jeunne, Isabelle Durand-Zaleski
BACKGROUND: Patient characteristics and survival outcomes in randomized trials may be different from those in real-life clinical practice. The objective of this study was to describe treatment pathways, safety, drug costs and survival in patients with metastatic Renal Cell Carcinoma (mRCC) in a real world setting. METHODS: A retrospective analysis was performed using IQVIA real world oncology cross-sectional survey data, a retrospective treatment database collecting anonymized patient-level data in Europe...
February 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29466345/symptom-dimensions-as-outcomes-in-interventions-for-patients-with-cancer-a-systematic-review
#16
Ingela Henoch, Cecilia Olsson, Maria Larsson, Karin Ahlberg
PROBLEM IDENTIFICATION: Symptom experience in patients with cancer consists of several dimensions, often measured descriptively within various populations but seldom used as intervention outcomes. This review aims at describing symptom dimensions as outcomes of interventions designed to alleviate symptoms in patients with cancer and to describe these interventions' effects on at least two symptom dimensions. 
. LITERATURE SEARCH: The PRISMA statement for reporting systematic reviews was used...
March 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29466256/the-impact-of-an-enhanced-recovery-after-surgery-program-on-patients-treated-for-gynecologic-cancer-in-the-community-hospital-setting
#17
Alberto A Mendivil, Justin R Busch, David C Richards, Heather Vittori, Bram H Goldstein
OBJECTIVES: The purpose of this study was to compare the outcomes of gynecologic oncology patients treated in the community hospital setting either under the auspices of an enhanced recovery after surgery (ERAS) protocol or in accordance with physician discretion. METHODS: We retrospectively evaluated a series of consecutive gynecologic oncology patients who were managed via open surgery in coincident with an ERAS pathway from January 2015 to December 2016. They were compared with a historical open surgery cohort who was treated from November 2013 to December 2014...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29466254/characteristics-and-prognosis-of-stage-i-ovarian-mucinous-tumors-according-to-expansile-or-infiltrative-type
#18
Sebastien Gouy, Marine Saidani, Amandine Maulard, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
BACKGROUND: The present study retrospectively determined the outcomes and prognoses in stage I mucinous ovarian carcinoma according to histological type (ie, expansile or infiltrative). METHODS: A centralized pathologic review of tumors in patients treated from 1976 to 2016 for ovarian mucinous carcinoma was performed by 2 expert pathologists according to the 2014 World Health Organization classification. Only patients with stage I disease were analyzed. Tumors were typed as expansile or infiltrative and oncological issues analyzed...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29465505/mutational-aberrations-detected-in-mucinous-epithelial-ovarian-cancer-of-asian-women
#19
Wen Yee Chay, Li Lian Kwok, Wen Ning Tiong, Sai Sakktee Krisna, Kiat Hon Lim, N Gopalkrishna Iyer, Liang Kee Goh, Daniel Shao-Weng Tan
BACKGROUND: Mucinous epithelial ovarian cancers (mEOCs) respond poorly to conventional chemotherapy and have a poor prognosis in advanced stages. The genomic landscape for mEOC in the Asian settings is ill defined. We seek to identify various mutational aberrations present in mEOC and correlate them with clinical outcomes. METHODS: A total of 199 cases of mEOC were identified from a prospectively maintained gynecologic oncology tumor database. DNA was extracted and analyzed for KRAS mutations by using Sanger sequencing...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29465436/orbital-exenteration-for-sinonasal-malignancies-indications-rehabilitation-and-oncologic-outcomes
#20
José G Vartanian, Ronaldo N Toledo, Thiago Bueno, Luiz P Kowalski
PURPOSE OF REVIEW: Review the recent literature regarding the management of orbital invasion in sinonasal malignant tumors. RECENT FINDINGS: There is a recent trend in preserving the orbit in cases of minimal invasion of periosteum and limited periorbit involvement, as well as in presence of good response to neoadjuvant chemotherapy, mainly in squamous cell carcinoma and neuroendocrine histologies. SUMMARY: The decision about orbital exenteration in cases of sinonasal malignancies is facilitated if the patient already has clear clinical signs of intraconal invasion such as visual loss, restriction of ocular mobility or infiltration of the eyeglobe...
February 19, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
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