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https://www.readbyqxmd.com/read/29044954/c3-symmetric-tricyclo-2-2-1-02-6-heptane-3-5-7-triol
#1
Volodymyr Kozel, Constantin-Gabriel Daniliuc, Peer Kirsch, Günter Haufe
A straightforward access to a hitherto unknown C3-symmetric tricyclic triol both in racemic and enantiopure forms has been elaborated. Treatment of 7-tert-butoxynorbornadiene with peroxycarboxylic acids provided mixtures of C1- and C3-symmetric 3,5,7-triacyloxy-nortricyclenes via transannular π-cyclization and substitution of the tert-butoxy group. Refluxing in formic acid, the C1-symmetric esters were converted to the C3-symmetric formate. Hydrolysis gave diastereoisomeric triols, which were separated by recrystallization...
October 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29044536/effect-of-matrix-metalloproteinase-inhibitor-on-disrupted-e-cadherin-after-acid-exposure-in-the-human-nasal-epithelium
#2
Byoungjae Kim, Hyun-Ji Lee, Nu-Ri Im, Doh Young Lee, Cha Young Kang, Il-Ho Park, Seung Hoon Lee, Sang Hag Lee, Seung-Kuk Baek, Tae Hoon Kim
OBJECTIVE: Laryngopharyngeal reflux disease (LPRD) is one of potential factors in recalcitrant chronic rhinosinusitis with or without polyps. An increase in junctional permeability in the nasal mucosa in LPRD may be due to disrupted protein bridge formation with cell-to-cell adhesion molecules such as E-cadherin. Despite the relationship between nasal mucosal inflammation and LPRD, the clear mechanism by which acid reflux affects the nasal epithelium remains unclear. METHODS: The expression levels and distribution patterns of E-cadherin in primary culture of nasal epithelial cells after acid exposure with or without dexamethasone and matrix metalloproteinase (MMP) inhibitor were determined using Western blot and immunocytochemistry...
October 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29043691/-analysis-of-hypertrophic-pyloric-stenosis-size-does-matter
#3
Y González Ruiz, A Siles Hinojosa, N Álvarez García, R Fernández Atuán, P Bragagnini Rodríguez, J Elías Pollina
OBJECTIVES: To analyze the correlation between pyloric size and evolution of patients surgically treated for infantile hypertrophic pyloric stenosis (IHPS). PATIENTS AND METHODS: We realized a retrospective study of 109 patients undergoing IHPS in 5 years. We analyzed by χ2 test if a correlation between evolution time, age and postoperative vomiting and gastroesophageal reflux disease (GERD), and pyloric muscle thickness (group A > 4.5 mm and group B ≤ 4...
July 20, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29043549/prevalence-and-predictors-of-gastroesophageal-reflux-disease-after-laparoscopic-sleeve-gastrectomy
#4
Saad Althuwaini, Fahad Bamehriz, Abdullah Aldohayan, Waleed Alshammari, Saleh Alhaidar, Mazen Alotaibi, Abdullah Alanazi, Hossam Alsahabi, Majid Abdularahman Almadi
BACKGROUND AND AIMS: Laparoscopic sleeve gastrectomy (LSG) might be associated with a new onset or worsening of gastroesophageal reflux disease (GERD). We aim to evaluate the prevalence of post-LSG GERD symptoms and its predictors. METHODS: We included patients who underwent primary LSG at a university hospital from 2009 to 2015. We used the GERD-Health-Related Quality of Life (GERD-HRQL) questionnaire and included questions regarding regurgitation to evaluate symptoms before and after LSG; each item was scored from 1 to 5 based on the symptom severity...
October 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29043223/amygdalin-contents-in-peaches-at-different-fruit-development-stages
#5
Suk-Hee Lee, Angela Oh, Seo-Hee Shin, Ha-Na Kim, Woo-Won Kang, Shin-Kyo Chung
Amygdalin contents of the seeds, endocarps, and mesocarps from three peach cultivars (i.e., Stone Peach, Hikawa Hakuho, and Bakhyang) were measured at three stages of fruit development (stone-hardening, fruit enlargement, and ripening). The peach samples were dried and defatted with a Soxhlet apparatus, reflux extracted with methanol, and analyzed using reverse phase high-performance liquid chromatography. During all fruit development stages, the amygdalin contents in the seeds were higher than those in the endocarps and mesocarps...
September 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29042857/clinical-implications-of-associations-between-headache-and-gastrointestinal-disorders-a-study-using-the-hallym-smart-clinical-data-warehouse
#6
Sang-Hwa Lee, Jae-June Lee, Youngsuk Kwon, Jong-Ho Kim, Jong-Hee Sohn
BACKGROUND: The brain and gastrointestinal (GI) tract are strongly connected via neural, endocrine, and immune pathways. Previous studies suggest that headaches, especially migraines, may be associated with various GI disorders. However, upper GI endoscopy in migraineurs has shown a low prevalence of abnormal findings. Also, the majority of studies have not demonstrated an association between Helicobacter pylori (HP) infection and migraine, although a pathogenic role for HP infection in migraines has been suggested...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29041918/the-diagnostic-value-of-pepsin-detection-in-saliva-for-gastro-esophageal-reflux-disease-a-preliminary-study-from-china
#7
Xing Du, Feng Wang, Zhiwei Hu, Jimin Wu, Zhonggao Wang, Chao Yan, Chao Zhang, Juan Tang
BACKGROUND: None of current diagnostic methods has been proven to be a reliable tool for gastro-esophageal reflux disease (GERD). Pepsin in saliva has been proposed as a promising diagnostic biomarker for gastro-esophageal reflux. We aimed to determine the diagnostic value of salivary pepsin detection for GERD. METHODS: Two hundred and fifty patients with symptoms suggestive of GERD and 35 asymptomatic healthy volunteers provided saliva on morning waking, after lunch and dinner for pepsin determination using the Peptest lateral flow device...
October 17, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29040685/a-pooled-analysis-of-dietary-sugar-carbohydrate-intake-and-esophageal-and-gastric-cardia-adenocarcinoma-incidence-and-survival-in-the-usa
#8
Nan Li, Jessica L Petrick, Susan E Steck, Patrick T Bradshaw, Kathleen M McClain, Nicole M Niehoff, Lawrence S Engel, Nicholas J Shaheen, Harvey A Risch, Thomas L Vaughan, Anna H Wu, Marilie D Gammon
Background: During the past 40 years, esophageal/gastric cardia adenocarcinoma (EA/GCA) incidence increased in Westernized countries, but survival remained low. A parallel increase in sugar intake, which may facilitate carcinogenesis by promoting hyperglycaemia, led us to examine sugar/carbohydrate intake in association with EA/GCA incidence and survival. Methods: We pooled 500 EA cases, 529 GCA cases and 2027 controls from two US population-based case-control studies with cases followed for vital status...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040484/esophagocardioplasty-vagotomy-antrectomy-and-roux-en-y-gastrojejunostomy-indication-in-cases-with-severe-esophageal-motor-disfunction
#9
I Braghetto, O Korn, A Csendes, J C Frias
Almost 10% of patients with Crest syndrome associated with severe gastroesophageal reflux and 5-10% of patients with failed cardiomyotomy for achalasia present with cardial or distal esophageal organic stricture. Some of these cases are poor risk patients for surgery and therefore the surgeon must offer a safe procedure with low morbimortality, keeping in mind the pathophysiological motor pattern of these patients.In order to treat the stricture to improve the esophageal transit we treated patients with esophagocardioplasty associated with vagotomy-antrectomy and Roux-en-Y gastrojejunostomy, thereby avoiding the potential acid or biliary reflux in poor risk patients in whom esophagectomy would be a very deleterious procedure...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29040001/is-gastroesophageal-reflux-disease-associated-with-primary-acquired-nasolacrimal-duct-obstruction
#10
Sonul Mehta, Gui-Shuang Ying, Ahsen Hussain, John T Harvey
PURPOSE: To determine if patients with primary acquired nasolacrimal duct obstruction (PANDO) have an increased prevalence of gastroesophageal reflux disease (GERD) compared to the general population. METHODS: Cross-sectional case-control study. The Mayo Clinic Reflux Disease Questionnaire (RDQ) is used to help physicians diagnose GERD. The retrospective group consisted of patients who previously had a dacryocystorhinostomy (DCR) over a 4-year period by one surgeon (JTH) at one institution...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/29039894/ureteral-orifice-involvement-by-urothelial-carcinoma-long-term-oncologic-and-functional-outcomes
#11
Muammer Altok, Ali F Sahin, Mehmet I Gokce, Gokhan R Ekin, Rauf Taner Divrik
PURPOSE: Bladder cancer (BC) may involve the ureteral orifice, and the resection of the orifice has oncological and functional consequences such as development of upper tract urothelial carcinoma (UTUC), vesicoureteral reflux or ureteral stenosis. The aim of this study was to investigate the oncological and functional outcomes of the ureteral orifice resection in BC patients and determine the predictive factors for UTUC development. MATERIALS AND METHODS: A total of 1359 patients diagnosed with BC, between 1992 and 2012, were reviewed retrospectively...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29039888/which-is-best-method-for-instillation-of-topical-therapy-to-the-upper-urinary-tract-an-in-vivo-porcine-study-to-evaluate-three-delivery-methods
#12
Zhenbang Liu, Junxiang Ng, Arianto Yuwono, Yadong Lu, Yung Khan Tan
PURPOSE: To compare the staining intensity of the upper urinary tract (UUT) urothelium among three UUT delivery methods in an in vivo porcine model. MATERIALS AND METHODS: A fluorescent dye solution (indigo carmine) was delivered to the UUT via three different methods: antegrade perfusion, vesico-ureteral reflux via indwelling ureteric stent and retrograde perfusion via a 5F open-ended ureteral catheter. Twelve renal units were tested with 4 in each method. After a 2-hour delivery time, the renal-ureter units were harvested en bloc...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29039589/partial-monosomy-8p-and-trisomy-16q-in-two-children-with-developmental-delay-detected-by-array-comparative-genomic-hybridization
#13
Zoe Papadopoulou, Ioannis Papoulidis, Stavros Sifakis, Georgios Markopoulos, Annalisa Vetro, Angeliki-Maria Vlaikou, Monica Ziegler, Thomas Liehr, Loretta Thomaidis, Orsetta Zuffardi, Maria Syrrou, Kitsos George, Emmanouil Manolakos
Two cases of liveborn unrelated children with developmental delay and overlapping unbalanced translocations der(8)t(8;16)(p23.2;q23.3) and der (8)t(8;16)(p23.1;q23.1), leading to partial monosomy 8p and partial trisomy 16q, are reported in the present study. The first patient was a 10‑year‑old boy with mild developmental delay and minor congenital anomalies (borderline microcephaly, clinodactyly, hypertelorism, epicanthus, mild systolic murmur and kidney reflux). The second patient was a 3 year‑old girl with developmental delay, gross motor milestone delay and dysmorphic features...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038782/jejuno-jejunal-intussusception-in-a-guinea-pig-cavia-porcellus
#14
Tara J Fetzer, Christoph Mans
An approximately four-year-old male castrated guinea pig (Cavia porcellus) was presented for painful defecation with a 24-hour history of hyporexia and intermittent episodes of rolling behavior. Upon presentation the patient was quiet, alert, and responsive, and mildly hypothermic. Abdominal palpation revealed an approximately 2-cm long oblong mass within the caudal abdomen. Abdominal radiographs revealed gastric dilation without volvulus and a peritoneal mass effect. The patient was euthanized following gastric reflux of brown malodorous fluid from his nares and oral cavity...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29037470/pathophysiology-of-gastroesophageal-reflux-disease
#15
Jan Tack, John E Pandolfino
The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric refluxate is a noxious material that injures the esophagus and elicits symptoms. Esophageal exposure to gastric refluxate is the primary determinant of disease severity. This exposure arises via compromise of the anti-reflux barrier and reduced ability of the esophagus to clear and buffer the refluxate, leading to reflux disease. However, complications and symptoms also occur in the context of normal reflux burden, when there is either poor epithelial resistance or increased visceral sensitivity...
October 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29037468/insights-into-the-pathophysiology-of-esophageal-adenocarcinoma
#16
Michael Quante, Trevor A Graham, Marnix Jansen
Although researchers have identified genetic alterations that contribute to development of esophageal adenocarcinoma, we know little about features of patients or environmental factors that mediate progression of chronic acid biliary reflux to Barrett's esophagus and cancer. Increasing our understanding of the mechanisms by which normal squamous epithelium progresses to early-stage invasive cancer will help formulate rational surveillance guidelines and allow us to divest resources away from patients at low risk of malignancy...
October 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29037363/a-systematic-review-and-meta-analysis-of-two-novel-techniques-of-nonthermal-endovenous-ablation-of-the-great-saphenous-vein
#17
REVIEW
Cornelis G Vos, Çağdaş Ünlü, Jan Bosma, Clarissa J van Vlijmen, A Jorianne de Nie, Michiel A Schreve
BACKGROUND: Endothermal treatment of the great saphenous vein (GSV) has become the first-line treatment for superficial venous reflux. Nonthermal ablation has potential benefits for acceptability by patients and decreased risk of nerve injury. We performed a systematic review and meta-analysis to evaluate the efficacy of mechanochemical endovenous ablation (MOCA) and cyanoacrylate vein ablation (CAVA) for GSV incompetence. METHODS: MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, and Cochrane databases were searched for papers published between January 1966 and December 2016...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29036607/endoscopic-and-histopathologic-reflux-associated-mucosal-damage-in-the-remnant-esophagus-following-transthoracic-esophagectomy-for-cancer-5-year-long-term-follow-up
#18
H F Fuchs, H M Schmidt, M Meissner, S Brinkmann, M Maus, M Bludau, W Schröder, A H Hölscher, J M Leers
Gastroesophageal reflux is a common problem following esophagectomy and reconstruction with gastric interposition. Despite a routine prescription of proton pump inhibitors, reflux-associated mucosal damage in the remnant esophagus is frequently observed. Purpose of this study is to evaluate mucosal damage in the esophageal remnant during long-term follow-up and to compare the prevalence of this damage between the subgroups of esophageal squamous cell and adenocarcinoma. All patients undergoing transthoracic Ivor-Lewis esophagectomy were prospectively entered in our IRB approved database...
September 21, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29036585/ambulatory-ph-impedance-pressure-monitoring-as-a-diagnostic-tool-for-the-reflux-cough-syndrome
#19
T V K Herregods, A Pauwels, J Jafari, D Sifrim, A J P M Smout, A J Bredenoord, J Tack
Gastroesophageal reflux is considered to be a significant contributing factor to chronic unexplained cough. Patients are often presumed to have reflux-induced cough and are exposed to high-dose and long-term empirical therapy with proton pump inhibitors (PPIs) despite the limited treatment efficacy in this population. We aimed to assess the diagnostic value of 24-hour ambulatory pH-impedance-pressure monitoring for the diagnosis of reflux-induced chronic cough. In this multicenter study, we evaluated 192 patients with chronic cough using 24-hour pH-impedance-pressure monitoring off PPIs...
September 27, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29034419/esophagitis-unrelated-to-reflux-disease-current-status-and-emerging-diagnostic-challenges
#20
Melanie E Johncilla, Amitabh Srivastava
There has been much progress in our understanding of esophageal inflammatory disorders in the past few years. This is particularly true about esophageal eosinophilia and PPI responsiveness, lymphocytic esophagitis and motility disorders, and short-term risk of neoplasia in esophageal leukoplakia. The current review will summarize esophageal injury patterns that primarily occur due to non-reflux causes, with a focus on usual pitfalls in biopsy diagnosis and recent advances in our knowledge of the more common forms of esophagitis...
October 15, 2017: Virchows Archiv: An International Journal of Pathology
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