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Systems Thinking; System Dynamics; Modeling and Simulations; Measurement

Johann P Kuhtz-Buschbeck, Angela Drake-Holland, Mark I M Noble, Brigitte Lohff, Jochen Schaefer
In the late 19th century, German physiologist Otto Frank (1865-1944) embarked on a near life-long research program of laying down the mathematical, methodological, and theoretical foundations in order to understand and define the performance of the heart and circulatory system in all their complexity. The existence of the "Frank-Starling law" testifies to this. Two of his seminal publications have been translated into English previously, introducing Frank's research on the dynamics of the heart and the arterial pulse to a wider audience...
May 1, 2018: Journal of Molecular and Cellular Cardiology
Jakob P Ulmschneider, Martin B Ulmschneider
Ever since the first molecular mechanics computer simulations of biological molecules became possible, there has been the dream to study all complex biological phenomena in silico, simply bypassing the enormous experimental challenges and their associated costs. For this, two inherent requirements need to be met: First, the time scales achievable in simulations must reach up to the millisecond range and even longer. Second, the computational model must accurately reproduce what is measured experimentally. Despite some recent successes, the general consensus in the field to date has been that neither of these conditions have yet been met and that the dream will be realized, if at all, only in the distant future...
May 15, 2018: Accounts of Chemical Research
Kenneth Ip, Kaiming She, Kemi Adeyeye
Recovering heat from waste water discharged from showers to preheat the incoming cold water has been promoted as a cost-effective, energy-efficient, and low-carbon design option which has been included in the UK's Standard Assessment Procedure (SAP) for demonstrating compliance with the Building Regulation for dwellings. Incentivized by its carbon cost-effectiveness, waste water heat exchangers (WWHX) have been selected and incorporated in a newly constructed Sports Pavilion at the University of Brighton in the UK...
October 18, 2017: Environmental Science and Pollution Research International
Geoff Kaufman, Mary Flanagan, Max Seidman, Simone Wien
OBJECTIVE: This article presents the design and empirical investigation of the "RePlay Health" game ( ), a novel "role-playing sport" derived from a complex, data-driven, computational simulation of healthcare dynamics. By immersing players in a fictional world in which they take on the role of characters facing specific behavioral and environmental risk factors, the "RePlay Health" game models the impact of health and healthcare policy on individual-level livelihood and community-level productivity...
August 2015: Games for Health
G Foffi, A Pastore, F Piazza, P A Temussi
More than 60 years of biochemical and biophysical studies have accustomed us to think of proteins as highly purified entities that act in isolation, more or less freely diffusing until they find their cognate partner to bind to. While in vitro experiments that reproduce these conditions largely remain the only way to investigate the intrinsic properties of molecules, this approach ignores an important factor: in their natural milieu , proteins are surrounded by several other molecules of different chemical nature, and this crowded environment can considerably modify their behaviour...
August 2, 2013: Physical Biology
Dhawal Shah, Jianguo Li, Abdul Rajjak Shaikh, Raj Rajagopalan
We examine the interaction of aromatic residues of proteins with arginine, an additive commonly used to suppress protein aggregation, using experiments and molecular dynamics simulations. An aromatic-rich peptide, FFYTP (a segment of insulin), and lysozyme and insulin are used as model systems. Mass spectrometry shows that arginine increases the solubility of FFYTP by binding to the peptide, with the simulations revealing the predominant association of arginine to be with the aromatic residues. The calculations further show a positive preferential interaction coefficient, Γ(XP), contrary to conventional thinking that positive Γ(XP)'s indicate aggregation rather than suppression of aggregation...
January 2012: Biotechnology Progress
George Kampis, László Gulyás
This is a position paper on phenotype-based evolution modeling. It argues that evolutionary complexity is essentially a functional kind of complexity, and for it to evolve, a full body, or, in other words, a dynamically defined, deeply structured, and plasticity-bound phenotype is required. In approaching this subject, we ask and answer some key questions, which we think are interrelated. The questions we discuss and the answers we propose are: (a) How should complexity growth be measured or operationalized in natural and artificial systems? Evolutionary complexity is akin to that of machines, and to operationalize it, we need to study how machinelike organismic functions work and develop...
2008: Artificial Life
Erol Başar, Bahar Güntekin
The Cartesian System is a fundamental conceptual and analytical framework related and interwoven with the concept and applications of Newtonian Dynamics. In order to analyze quantum processes physicist moved to a Probabilistic Cartesian System in which the causality principle became a probabilistic one. This means the trajectories of particles (obeying quantum rules) can be described only with the concept of cloudy wave packets. The approach to the brain-body-mind problem requires more than the prerequisite of modern physics and quantum dynamics...
April 2007: International Journal of Psychophysiology
Toru Yao
The knowledge gleaned from genome sequencing and post-genome analyses is having a very significant impact on a whole range of life sciences and their applications. 'Genome-wide analysis' is a good keyword to represent this tendency. Thanks to innovations in high-throughput measurement technologies and information technologies, genome-wide analysis is becoming available in a broad range of research fields from DNA sequences, gene and protein expressions, protein structures and interactions, to pathways or networks analysis...
July 2002: Progress in Biophysics and Molecular Biology
S I Stepanova, V I Miasnikov, O P Kozerenko, V P Sal'nitskiĭ, A P Nechaev
Reviewed are the modern notions of the main psychological concerns regarding a mission to Mars which are maintenance of mental health, high professional reliability, and successful readaptation of the Martian crew on return to Earth. The unprecedent trail-blazing interplanetary mission distinguished by autonomy, long period, international crew and a broad range of tasks to tend will set particularly difficult requirements to the psychological support system. Among them prioritized are purposeful character building and training of future crew members already in childhood and youth...
2001: Aviakosmicheskaia i Ekologicheskaia Meditsina, Aerospace and Environmental Medicine
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