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https://www.readbyqxmd.com/read/29346857/higher-energy-intake-variability-as-predisposition-to-obesity-novel-approach-using-interquartile-range
#1
Martin Forejt, Zuzana Derflerová Brázdová, Jan Novák, Filip Zlámal, Marie Forbelská, Petr Bienert, Petra Duchečková, Miroslava Zavřelová, Aneta Jackowská, Miluše Jurášková, Nabil Salah, Julie Bienertová-Vašků
No abstract text is available yet for this article.
December 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29346845/a-new-approach-to-the-evaluation-of-local-muscular-load-while-typing-on-a-keyboard
#2
Anna Schlenker, Tomáš Tichý
No abstract text is available yet for this article.
December 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29346832/diagnosis-of-lumbar-spinal-stenosis-with-functional-myelography
#3
Matthias Morgalla, Sandra Frantz, Roberto Alexandre Dezena, Carlos Umberto Pereira, Marcos Tatagiba
BACKGROUND AND STUDY AIMS:  The diagnosis of a lumbar spinal stenosis demands advanced diagnostic radiologic techniques. In recent decades magnetic resonance imaging (MRI) has replaced myelography, now considered an old-fashioned technique. It was our hypothesis that functional myelography still plays an important role in selected cases. We investigated how our surgical strategy was influenced by the results of MRI, functional myelography, and postmyelography computed tomography (CT) in patients with a lumbar spinal stenosis...
January 18, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29346828/dynamic-posterior-stabilization-versus-posterior-lumbar-intervertebral-fusion-a-matched-cohort-study-based-on-the-spine-tango-registry
#4
Kathrin S Bieri, Kelly Goodwin, Emin Aghayev, Hans-Joachim Riesner, Ralph Greiner-Perth
PURPOSE:  The primary aim of dynamic stabilization is to stabilize the spine and preserve function without overstressing adjacent segments, which is a potential risk of fusion surgery. However, direct comparative analyses of the two approaches are still limited, and little is known about the association of patient-reported outcomes with these treatment options. OBJECTIVE:  To compare the clinical outcomes of dynamic posterior stabilization using the DSS Stabilization System (Paradigm Spine, LLC, New York, New York, United States) versus posterior lumbar intervertebral fusion (PLIF) based on data from a spine registry...
January 18, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29346792/pancreaticoduodenectomy-and-outcomes-for-groove-pancreatitis
#5
Fabiola Aguilera, Levan Tsamalaidze, Massimo Raimondo, Ruchir Puri, Horacio J Asbun, John A Stauffer
BACKGROUND/AIMS: The operative management of groove pancreatitis (GP) is still a matter of controversy and pancreaticoduodenectomy (PD) can be a high-risk procedure for patients. The aim of this study was to report our 9-year experience of surgical resection for GP and to review relevant literature. METHODS: A retrospective review of patients undergoing pancreatectomy for GP from August 1, 2008, through May 31, 2017 was performed. Patients with clinical, radiologic, and final pathologic confirmation of GP were included...
January 18, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29346781/laparoscopic-nephron-sparing-calycectomy-for-treating-fraley-s-syndrome
#6
Francesco Porpiglia, Riccardo Bertolo, Enrico Checcucci, Daniele Amparore, Matteo Manfredi, Cristian Fiori
Background/Aims/Objectives: Various nephron-sparing approaches were described as part of surgical management for Fraley's syndrome, a rare anatomic variant of the renal vascular anatomy that compresses the upper pole infundibulum resulting in an upper calyceal obstruction and dilatation, with symptoms of flank pain and hematuria. To date, descriptions of minimally invasive correction techniques are anecdotal. METHODS: A retroperitoneal pure laparoscopic approach using the nephron-sparing technique was chosen in the presented case...
January 18, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29346770/integrative-analyses-of-de-novo-mutations-provide-deeper-biological-insights-into-autism-spectrum-disorder
#7
Atsushi Takata, Noriko Miyake, Yoshinori Tsurusaki, Ryoko Fukai, Satoko Miyatake, Eriko Koshimizu, Itaru Kushima, Takashi Okada, Mako Morikawa, Yota Uno, Kanako Ishizuka, Kazuhiko Nakamura, Masatsugu Tsujii, Takeo Yoshikawa, Tomoko Toyota, Nobuhiko Okamoto, Yoko Hiraki, Ryota Hashimoto, Yuka Yasuda, Shinji Saitoh, Kei Ohashi, Yasunari Sakai, Shouichi Ohga, Toshiro Hara, Mitsuhiro Kato, Kazuyuki Nakamura, Aiko Ito, Chizuru Seiwa, Emi Shirahata, Hitoshi Osaka, Ayumi Matsumoto, Saoko Takeshita, Jun Tohyama, Tomoko Saikusa, Toyojiro Matsuishi, Takumi Nakamura, Takashi Tsuboi, Tadafumi Kato, Toshifumi Suzuki, Hirotomo Saitsu, Mitsuko Nakashima, Takeshi Mizuguchi, Fumiaki Tanaka, Norio Mori, Norio Ozaki, Naomichi Matsumoto
Recent studies have established important roles of de novo mutations (DNMs) in autism spectrum disorders (ASDs). Here, we analyze DNMs in 262 ASD probands of Japanese origin and confirm the "de novo paradigm" of ASDs across ethnicities. Based on this consistency, we combine the lists of damaging DNMs in our and published ASD cohorts (total number of trios, 4,244) and perform integrative bioinformatics analyses. Besides replicating the findings of previous studies, our analyses highlight ATP-binding genes and fetal cerebellar/striatal circuits...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346736/light-activatable-red-blood-cell-membrane-camouflaged-dimeric-prodrug-nanoparticles-for-synergistic-photodynamic-chemotherapy
#8
Qing Pei, Xiuli Hu, Xiaohua Zheng, Shi Liu, Yawei Li, Xiabin Jing, Zhigang Xie
Biomimetic approach offers numerous opportunities to design therapeutic platforms with enhanced antitumor performance and biocompatibility. Herein we report a novel red blood cell membrane-camouflaged nanoparticle (RBC(M(TPC-PTX))) for synergistic chemo- and photodynamic therapy (PDT). Specifically, the inner core is mainly constructed by reactive oxygen species (ROS)-responsive PTX dimer (PTX2-TK) and photosensitizer 5,10,15,20-tetraphenylchlorin (TPC). In vitro experiments show that the prepared RBC(M(TPC-PTX)) is readily taken up into endosomes...
January 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29346726/the-effect-of-dielectric-environment-on-doping-efficiency-in-colloidal-pbse-nanostructures
#9
Qinghua Zhao, Tianshuo Zhao, Jiacen Guo, Wenxiang Chen, Mingliang Zhang, Cherie R Kagan
Doping, as a central strategy to control free carrier type and concentration in semiconductor materials, suffers from low efficiency at the nanoscale, especially in systems having high permittivity (ϵ) and large Bohr radii, such as lead chalcogenide nanocrystals (NCs) and nanowires (NWs). Here, we study dielectric confinement effects on the doping efficiency of lead chalcogenides nanostructures by integrating PbSe NWs in the platform of field effect transistors (FETs). Elemental Pb or In or elemental Se is deposited by thermal evaporation to remotely n- or p-dope the NWs...
January 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29346724/structural-and-biophysical-characterization-of-human-extl3-domain-organisation-glycosylation-and-solution-structure
#10
Wael Awad, Sven Kjellstrom, Gabriel Svensson Birkedal, Katrin Mani, Derek Thomas Logan
Heparan sulfate proteoglycans are proteins substituted with one or more heparan sulfate (HS) polysaccharides, found in abundance at cell surfaces. HS chains influence the activity of many biologically important molecules involved in cellular communication and signaling. The exostosin (EXT) proteins are glycosyltransferases in the Golgi apparatus that assemble HS chains on HSPGs. The EXTL3 enzyme mainly works as an initiator in HS biosynthesis. In this work, human lumenal N-glycosylated EXTL3 (EXTL3ΔN) was cloned, expressed in human embryonic kidney cells and purified...
January 18, 2018: Biochemistry
https://www.readbyqxmd.com/read/29346722/layer-by-layer-epitaxial-growth-of-defect-engineered-strontium-cobaltites
#11
Tassie Andersen, Seyoung Cook, Gang Wan, Hawoong Hong, Laurence D Marks, Dillon D Fong
Control over structure and composition of (ABO3) perovskite oxides offers exciting opportunities since these materials possess unique, tunable properties. Perovskite oxides with cobalt B-site cations are particularly promising, as the range of the cation's stable oxidation states leads to many possible structural frameworks. Here, we report growth of strontium cobalt oxide thin films by molecular beam epitaxy, and conditions necessary to stabilize different defect concentration phases. In situ X-ray scattering is used to monitor structural evolution during growth, while in situ X-ray absorption near-edge spectroscopy is used to probe oxidation state and measure changes to oxygen vacancy concentration as a function of film thickness...
January 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29346711/early-assessment-of-post-surgical-outcomes-with-pre-pectoral-breast-reconstruction-a-literature-review-and-meta-analysis
#12
Abhishek Chatterjee, Maurice Y Nahabedian, Allen Gabriel, David Macarios, Mousam Parekh, Fang Wang, Leah Griffin, Steven Sigalove
BACKGROUND: Pre-pectoral breast reconstruction is an emerging surgical approach. This study provides an early assessment of outcomes with the technique. METHODS: A comprehensive literature review was performed through searches of PubMed® /MEDLINE® to identify studies on pre-pectoral reconstruction. Patient characteristics and outcomes were extracted from studies and pooled. Linear relationships between complication rates and patient characteristics with pre-pectoral reconstruction were analyzed...
January 18, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29346709/rating-the-quality-of-a-body-of-evidence-on-the-effectiveness-of-health-and-social-interventions-a-systematic-review-and-mapping-of-evidence-domains
#13
Ani Movsisyan, Jane Dennis, Eva Rehfuess, Sean Grant, Paul Montgomery
INTRODUCTION: Rating the quality of a body of evidence is an increasingly common component of research syntheses on intervention effectiveness. This study sought to identify and examine existing systems for rating the quality of a body of evidence on the effectiveness of health and social interventions. METHODS: We used a multi-component search strategy to search for full-length reports of systems for rating the quality of a body of evidence on the effectiveness of health and social interventions published in English from 1995 onward...
January 18, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29346703/pursuing-personal-passion-learner-centered-research-mentoring
#14
William R Phillips
New researchers often face difficulty finding and focusing research questions. I describe a new tool for research mentoring, the Pursuing Personal Passion (P3) interview, and a systematic approach to help learners organize their curiosity and develop researchable questions aligned with their personal and professional priorities. The learner-centered P3 research interview parallels the patient-centered clinical interview. This paper reviews experience with 27 research mentees over the years 2009 to 2016, using the P3 approach to identify their initial research topics, classify their underlying passions and track the evolution into their final research questions...
January 2018: Family Medicine
https://www.readbyqxmd.com/read/29346689/initial-development-and-validation-of-a-family-medicine-attitudes-questionnaire
#15
Julie Phillips, Jacob Prunuske, Laurie Fitzpatrick, Brian Mavis
BACKGROUND AND OBJECTIVES: Although many curricular and policy interventions are designed to influence students' attitudes toward family medicine, assessment of these interventions is limited by lack of a comprehensive, validated measure of students' attitudes. We sought to develop and validate a questionnaire that effectively assesses medical student attitudes toward family medicine. METHODS: A 31-item questionnaire was assessed for internal, external, and content validity...
January 2018: Family Medicine
https://www.readbyqxmd.com/read/29346663/resident-participation-in-neighbourhood-audit-tools-a-scoping-review
#16
Aafke C L Hofland, Jeroen Devilee, Elise van Kempen, Lea den Broeder
Background: Healthy urban environments require careful planning and a testing of environmental quality that goes beyond statutory requirements. Moreover, it requires the inclusion of resident views, perceptions and experiences that help deepen the understanding of local (public health) problems. To facilitate this, neighbourhoods should be mapped in a way that is relevant to them. One way to do this is participative neighbourhood auditing. This paper provides an insight into availability and characteristics of participatory neighbourhood audit instruments...
February 1, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29346657/perspectives-on-queer-music-therapy-a-qualitative-analysis-of-music-therapists-reactions-to-radically-inclusive-practice
#17
Catherine E Boggan, Patrick R Grzanka, Candice L Bain
Background: The queer music therapy model was designed by Bain, Grzanka, and Crowe in 2016 as a novel therapeutic approach to affirm and empower LGBTQ+ identity through music. No data have been generated on how this model might actually be implemented, or the strengths and limitations of the model according to music therapy professionals. Objective: The purpose of this study was to build on Bain and colleagues' work by collecting music therapists' perspectives on queer music therapy and using these data to critically evaluate the model...
January 13, 2018: Journal of Music Therapy
https://www.readbyqxmd.com/read/29346654/evaluation-of-system-mapping-approaches-in-identifying-patient-safety-risks
#18
Mecit Can Emre Simsekler, James R Ward, P John Clarkson
Objective: While many system mapping approaches (SMAs) have been broadly used in safety-critical industries, few have so far been employed in the healthcare field to assist in the identification of patient safety risks. In this study, we evaluated a set of system modelling approaches to assess their potential contribution to the identification of risks affecting patient safety. The aim was to gain a greater understanding of the practical application of system modelling approaches with the help of the risk categorization framework developed in this study...
January 16, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29346624/data-driven-approaches-to-define-the-upper-limit-of-the-inter-movement-interval-of-periodic-leg-movements-during-sleep
#19
Raffaele Ferri, Alessandro Silvani, Francesco Rundo, Marco Zucconi, Debora Aricò, Oliviero Bruni, Luigi Ferini-Strambi, Mauro Manconi
Objective: to define statistically the upper limit of the inter-movement interval (IMI, the time interval between the onset of consecutive movements) of periodic leg movements during sleep (PLMS). Subjects and Methods: we computed the IMI distribution of a large sample (n = 141) of patients with restless legs syndrome (RLS) and analyzed it with two independent approaches, based on fitting either empirical functions or normal and exponential functions to the data...
January 13, 2018: Sleep
https://www.readbyqxmd.com/read/29346620/combating-global-antibiotic-resistance-emerging-one-health-concerns-in-lower-and-middle-income-countries
#20
Maya Nadimpalli, Elisabeth Delarocque-Astagneau, David C Love, Lance B Price, Bich-Tram Huynh, Jean-Marc Collard, Kruy Sun Lay, Laurence Borand, Awa Ndir, Timothy R Walsh, Didier Guillemot
Antibiotic misuse in lower- and middle-income countries (LMICs) contributes to the development of antibiotic resistance that can disseminate globally. Strategies specific to LMICs that seek to reduce antibiotic misuse by humans, but simultaneously improve antibiotic access, have been proposed. However, most approaches to date have not considered the growing impact of animal and environmental reservoirs of antibiotic resistance, which threaten to exacerbate the antibiotic resistance crisis in LMICs. In particular, current strategies do not prioritize the impacts of increased antibiotic use for terrestrial food-animal and aquaculture production, inadequate food safety, and widespread environmental pollution...
January 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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